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https://www.readbyqxmd.com/read/28337370/role-of-epidermal-growth-factor-receptor-in-lung-cancer-and-targeted-therapies
#1
REVIEW
Tie-Cheng Liu, Xin Jin, Yan Wang, Ke Wang
Lung cancer is the foremost cause of cancer-related deaths world-wide. Both, the major forms of lung cancer, Non-small cell lung cancer (NSCLC) and Small cell lung cancers (SCLC), have responded effectively to chemo-, radiation and adjuvant-therapies. Tumor removal through surgery also appeared as a good therapeutic strategy. However, these therapies demonstrated unfavourable side-effects, and hence novel drugs targeting lung cancer emerged essential. Activation of epidermal growth factor receptor (EGFR)-tyrosine kinases is a key reason for lung cancer progression...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/28334732/high-stmn1-level-is-associated-with-chemo-resistance-and-poor-prognosis-in-gastric-cancer-patients
#2
Tuya Bai, Takehiko Yokobori, Bolag Altan, Munenori Ide, Erito Mochiki, Mitsuhiro Yanai, Akiharu Kimura, Norimichi Kogure, Toru Yanoma, Masaki Suzuki, Pinjie Bao, Kyoichi Kaira, Takayuki Asao, Ayaka Katayama, Tadashi Handa, Navchaa Gombodorj, Masahiko Nishiyama, Tetsunari Oyama, Kyoichi Ogata, Hiroyuki Kuwano
BACKGROUND: Stathmin1 (STMN1) is a cytosolic phosphoprotein that regulates cellular microtubule dynamics and is known to have oncogenic activity. Despite several reports, its roles in gastric cancer (GC) remain unclear owing to a lack of analyses of highly metastatic cases. This study aimed to investigate STMN1 as a prognostic and predictive indicator of response to paclitaxel therapy in patients with GC, including inoperable cases. METHODS: Immunohistochemical analysis of STMN1 was performed on both operable (n=95) and inoperable GC (n=61) samples...
March 23, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28322154/mechanisms-and-drug-targets-for-pancreatic-cancer-chemoprevention
#3
Deepanshi Dhar, Komal Raina, Rajesh Agarwal
Pancreatic cancer management remains a major challenge to society. Poor prognosis results in dismal survival rates and quality of life for pancreatic cancer patients post chemo/radiation therapies. Although progress has been made in drug development for chemotherapeutics targeting pancreatic cancer, accompanying issues of resistance to these drugs renders the treatment futile. Emerging area of cancer chemoprevention is gaining importance with natural/dietary compounds serving as novel agents with strong anticancer properties; these are pleiotropic agents targeting multiple pathways with minimal toxicities in the surrounding normal tissue...
March 20, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28318642/stage-i-uterine-carcinosarcoma-matched-cohort-analyses-for-lymphadenectomy-chemotherapy-and-brachytherapy
#4
Brandon-Luke L Seagle, Margaux Kanis, Masha Kocherginsky, Jonathan B Strauss, Shohreh Shahabi
OBJECTIVE: To determine if lymphadenectomy, chemotherapy and radiotherapy are associated with survival benefit among women with stage I uterine carcinosarcoma. METHODS: Women with stage I uterine carcinosarcoma (n=5614) were identified from the 1998-2013 National Cancer Data Base. Kaplan-Meier survival estimates and Cox proportional-hazards regression models were used to evaluate predictors of overall survival. Effects of these predictors were also estimated using propensity score matched analyses for lymphadenectomy, adjuvant chemotherapy, and radiotherapy...
January 12, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28317560/stage-i-uterine-carcinosarcoma-matched-cohort-analyses-for-lymphadenectomy-chemotherapy-and-brachytherapy
#5
Brandon-Luke L Seagle, Margaux Kanis, Masha Kocherginsky, Jonathan B Strauss, Shohreh Shahabi
OBJECTIVE: To determine if lymphadenectomy, chemotherapy and radiotherapy are associated with survival benefit among women with stage I uterine carcinosarcoma. METHODS: Women with stage I uterine carcinosarcoma (n=5614) were identified from the 1998-2013 National Cancer Data Base. Kaplan-Meier survival estimates and Cox proportional-hazards regression models were used to evaluate predictors of overall survival. Effects of these predictors were also estimated using propensity score matched analyses for lymphadenectomy, adjuvant chemotherapy, and radiotherapy...
April 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28279066/patterns-of-care-for-radiotherapy-in-the-neoadjuvant-and-adjuvant-treatment-of-gastric-cancer-a-twelve-year-nationwide-cohort-study-in-korea
#6
Jee Suk Chang, Young Choi, Jaeyong Shin, Kyung Hwan Kim, Ki Chang Keum, Hyo Song Kim, Woong Sub Koom, Eun-Cheol Park
Purpose: Although Korea has the highest incidence of gastric cancer worldwide and D2-lymphadenectomies are routinely performed, radiotherapy (RT) practice patterns have not been well studied. Therefore, we examined RT usage trends for neoadjuvant/adjuvant patients and identified factors associated with RT. We also examined survival benefits and net medical cost advantages of adding RT. Materials and Methods: Patients diagnosed with gastric cancer who underwent gastrectomy from 2002-2013 were identified using National Health Insurance Service-National Sample Cohort...
March 8, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/28272681/correlation-of-cox-2-expression-in-colorectal-carcinoma-with-clinicopathological-features
#7
Sandhya Venkatachala, Manjula Rajendran
OBJECTIVE: Colorectal carcinoma is the most common neoplasm of the gastrointestinal tract. COX-2 expression is upregulated in colorectal carcinoma. Therefore its assessment would identify patients amenable to adjuvant anticyclooxygenase therapy. We studied COX-2 immunoexpression in colorectal adenocarcinoma and correlated it with clinicopathological features as age, gender, tumor location, tumor size, degree of differentiation, and TNM stage. MATERIAL AND METHOD: Sixty-five consecutive cases of colorectal adenocarcinoma were retrieved from the records of the Pathology Department of a tertiary care hospital...
February 4, 2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28258916/malignant-peripheral-nerve-sheath-tumor-of-the-tongue-with-an-unusual-pattern-of-recurrence
#8
Soumyajit Roy, Ajeet Kumar Gandhi, Bharti Devnani, Lavleen Singh, Bidhu Kalyan Mohanti
Malignant peripheral nerve sheath tumor (MPNST) of oral cavity is an extremely uncommon malignancy. Less than 15 cases have been reported since 1973 though none of them describes a distant metastasis. We present a rare case of MPNST of the tongue who presented with features of hypoglossal nerve palsy. Incisional biopsy showed a malignant spindle cell tumor in the sub-epithelial connective tissue. The tumor cells were immune-positive for S-100. He underwent surgery followed by adjuvant chemo-radiation. Later the disease recurred in the form of isolated pelvic bone metastasis...
February 28, 2017: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/28240522/coping-strategies-and-experiences-in-women-with-a-primary-breast-cancer-diagnosis
#9
Sepideh Hajian, Esmat Mehrabi, Masoomeh Simbar, Mohammad Houshyari
Background: Women with breast cancer experience problems in multiple aspects of their lives, but applying effective strategies can result in enhancing their quality of life and their psychosocial adaptation to the disease. However, there is little information about the strategies that women use to cope with complications associated with their experiences following a breast cancer diagnosis. Objectives: The aim of this study was to explore the experience of coping behavior and the main strategies that women use in dealing with a breast cancer diagnosis...
January 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28239999/glioblastoma-multiforme-a-review-of-its-epidemiology-and-pathogenesis-through-clinical-presentation-and-treatment
#10
Farina Hanif, Kanza Muzaffar, Kahkashan Perveen, Saima M Malhi, Shabana U Simjee
Glioblastoma multiforme (GBM) is one of the most malignant types of central nervous system tumors. Despite advances in treatment modalities it remains largely incurable. The objective of our review is to provide a holistic picture of GBM epidemiology, etiology, pathogenesis, clinical findings and treatment. A literature search was conducted for GBM at PubMed and Google Scholar, with relevant key words like glioblastoma multiforme, pathogenesis, signs and symptoms, treatment etc., and papers published until 2015 were reviewed...
January 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28236067/mixed-pineal-mature-teratoma-and-germinoma-in-two-brothers-of-the-fraternal-triplets
#11
Gordan Grahovac, Tord Alden, Wadhwani Nitin
INTRODUCTION: Intracranial teratomas are rare germ cell neoplasms that contain tissues derived from all three germ cell layers and most commonly occurring during childhood. This is the first report of pineal region mixed mature teratoma and germinoma in two fraternal brothers of fraternal triplets. CASE PRESENTATION: We report the case of a mixed mature teratoma and germinoma of the pineal region in two brothers of fraternal triplets. Older brother was initially diagnosed at the age of 11 years with the pure teratoma of the pineal region but the review of the pathology 3 years after initial surgery revealed the mixed mature teratoma with 5% germinomatous component...
February 24, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28188953/minimizing-adjuvant-treatment-after-transoral-robotic-surgery-through-surgical-margin-revision-and-exclusion-of-radiographic-extracapsular-extension-a-prospective-observational-cohort-study
#12
Benoit Morisod, Ioana I Venara-Vulpe, Stephen Alzuphar, Yan Monnier, Massimo Bongiovanni, Patric Hagmann, Hanan Bouchaab, Jean Bourhis, Christian Simon
BACKGROUND: We investigated in a prospective cohort of patients treated with trans-oral robotic surgery (TORS) for oropharyngeal cancer (OPC), who were selected for the absence of radiographic extra-capsular extension (ECS) and surgically revised for inadequate margins, the possibility of reducing adjuvant radiation (RT)/chemo-radiation therapy (CRT) without jeopardizing tumor control and functional outcome. METHODS: We conducted a prospective observational cohort of patients treated with TORS for oropharyngeal cancer...
February 11, 2017: Head & Neck
https://www.readbyqxmd.com/read/28179157/the-influence-of-cell-and-nanoparticle-properties-on-heating-and-cell-death-in-a-radiofrequency-field
#13
Yuri Mackeyev, Colette Mark, Natasha Kumar, Rita E Serda
The use of non-invasive radiofrequency (RF) energy to induce mild thermal and non-thermal effects in cancer tissue is under study as an adjuvant to chemo, radio or immuno therapy. This study examines cell specific sensitivities to RF exposure and the potential of nanoparticles to elevate heating rates or enhance biological effects. Increases in the heating rate of water in an RF field operating at 13.56MHz (0.004-0.028°C/s) were positively correlated with concentration of hybrid nanoparticles (1-10mg/ml) consisting of water soluble malonodiserinolamide [60]fullerene (C60-ser) conjugated to the surface of mesoporous silica nanoparticles (SiO2-C60)...
February 5, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28178994/doxycycline-attenuates-breast-cancer-related-inflammation-by-decreasing-plasma-lysophosphatidate-concentrations-and-inhibiting-nf-%C3%AE%C2%BAb-activation
#14
Xiaoyun Tang, Xianyan Wang, Yuan Y Zhao, Jonathan M Curtis, David N Brindley
BACKGROUND: We previously discovered that tetracyclines increase the expression of lipid phosphate phosphatases at the surface of cells. These enzymes degrade circulating lysophosphatidate and therefore doxycycline increases the turnover of plasma lysophosphatidate and decreases its concentration. Extracellular lysophosphatidate signals through six G protein-coupled receptors and it is a potent promoter of tumor growth, metastasis and chemo-resistance. These effects depend partly on the stimulation of inflammation that lysophosphatidate produces...
February 8, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/28176976/the-importance-of-surgery-as-part-of-multimodal-therapy-in-rapid-progressive-primary-extraosseous-ewing-sarcoma-of-the-cervical-intra-and-epidural-space
#15
Richard Bostelmann, Mario Leimert, Hans Jakob Steiger, Kristin Gierga, Athanasios K Petridis
Primary extraosseous Ewing sarcomas (EESs) are an extremely rare pathological entity. Less than 32 cases have been reported in the literature. Here we report an uncommon case with very rapid progression in the cervical region with extra- and intradural involvement. We present a thorough review of the literature and discuss possible treatment modalities. The Medline database was searched using the search terms: Ewing sarcoma, extraosseus tumour, treatment, management, cervical spine. A previously healthy 29-year-old man complained of right-sided radiculopathy (C7)...
October 24, 2016: Clinics and Practice
https://www.readbyqxmd.com/read/28165132/nonmuscle-invasive-bladder-cancer-what-s-changing-and-what-has-changed
#16
Ramanitharan Manikandan, Oscar Rodriguez, Rubén Parada, Joan Palou Redorta
PURPOSE: Nonmuscle-invasive bladder cancer (NMIBC) is a challenging disease to manage primarily due to its varied clinical course. The management of NMIBC has witnessed a widespread change with respect to its diagnosis and treatment. Although transurethral resection (TUR) and adjuvant bacillus Calmette-Guerin (BCG) stills remain the cornerstone, newer protocols has come into vogue to achieve optimal care. On the basis of a literature review, we aimed to establish 'what changes has already occurred and what is expected in the future' in NMIBC...
February 3, 2017: Urologia
https://www.readbyqxmd.com/read/28161894/mediator-of-dna-damage-checkpoint-protein-1-mdc1-as-a-prognostic-marker-for-patients-with-oral-squamous-cell-carcinoma
#17
Jigna Harshadbhai Dave, Hemangini Hasit Vora, Nandita Radhabinod Ghosh, Trupti Indravadan Trivedi
BACKGROUND: The mediator of DNA damage checkpoint protein 1 (MDC1) is involved in the regulation of cell cycle check points and recruitment of several repair proteins to the site of DNA double stranded breaks (DSBs). The present study aims to correlate the expression of MDC1 protein with clinicopathological parameters and to evaluate its prognostic significance in patients with oral squamous cell carcinoma (OSCC). METHODS: MDC1 protein expression was evaluated immunohistochemically from untreated 100 patients with OSCC using modified H-score method...
February 4, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28152930/geographic-practice-patterns-in-the-selection-of-adjuvant-dose-dense-dd-chemotherapy-among-stage-1-breast-cancer-bc-patients
#18
Michael Baum, Charles L Bennett, Kevin Knopf, Dinah Faith Q Huff
126 Background: Oncology Analytics (OA) reviewed drug pre-authorization requests amongst populations with similar demographic features. Small stage I, node-negative, margin-free BC may be treated by observation, hormone therapy or adjuvant chemotherapy. If chemo is used, either standard or DD schedules may be requested. Patient age, HER2 status, and ER expression affect the choice of treatment. METHODS: We analyzed data from oncology drug preauthorization requests for BC protocols submitted by providers in FL, GA and TX from October 1, 2013 through September 30, 2015...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28152687/feasibility-acceptability-and-efficacy-of-a-proactive-telephone-intervention-to-improve-toxicity-management-during-chemotherapy
#19
Cassandra McKay, Heekyung Han, Sonal Gandhi, Nicole Beatrice Laferriere, Clare Atzema, Kelvin K Chan, Doris Howell, Vishal Kukreti, Yvonne Leung, Aliya Pardhan, Sandy Mitchell, Marla Nayer, Mark Pasetka, Jane Yao, Erin Redwood
105 Background: Chemotherapy (chemo) is associated with a significant risk of toxicity, which often peaks between ambulatory visits. Consequently, effective remote symptom management support is essential to optimize self-management and resource use, including emergency department visits and hospitalizations (ED+H) during chemo. The aim of this study was to examine the feasibility, acceptability and effects of a telephone management intervention on symptomatic toxicity and resource use during chemo for early stage breast cancer (EBC)...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28122895/21-gene-recurrence-score-and-locoregional-recurrence-in-node-positive-er-positive-breast-cancer-treated-with-chemo-endocrine-therapy
#20
Eleftherios P Mamounas, Qing Liu, Soonmyung Paik, Frederick L Baehner, Gong Tang, Jong-Hyeon Jeong, S Rim Kim, Steven M Butler, Farid Jamshidian, Diana B Cherbavaz, Amy P Sing, Steven Shak, Thomas B Julian, Barry C Lembersky, D Lawrence Wickerham, Joseph P Costantino, Norman Wolmark
BACKGROUND: The 21-gene recurrence score (RS) predicts risk of locoregional recurrence (LRR) in node-negative, estrogen receptor (ER)-positive breast cancer. We evaluated the association between RS and LRR in node-positive, ER-positive patients treated with adjuvant chemotherapy plus tamoxifen in National Surgical Adjuvant Breast and Bowel Project B-28. METHODS: B-28 compared doxorubicin/cyclophosphamide (AC X 4) with AC X 4 followed by paclitaxel X 4. Tamoxifen was given to patients age 50 years or older and those younger than age 50 years with ER-positive and/or progesterone receptor-positive tumors...
January 2017: Journal of the National Cancer Institute
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