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https://www.readbyqxmd.com/read/28713677/radio-immunotherapy-and-chemo-immunotherapy-as-a-novel-treatment-paradigm-in-malignant-pleural-mesothelioma
#1
REVIEW
Licun Wu, Marc de Perrot
Malignant pleural mesothelioma (MPM) is an aggressive neoplasm with poor outcome. Novel radical radiation techniques using intensity modulated radiation therapy (IMRT) have become an important component of therapy in mesothelioma. Immunotherapy also provides new therapeutic options. However, how best to integrate immunotherapy with standard therapy such as radiation, chemotherapy and surgery remains unknown. A change of paradigm from adjuvant normofractionation to induction accelerated hypofractionated hemithoracic radiation could provide a platform to combine immunotherapy due to the potential benefit of short course high dose radiation on the immune system...
June 2017: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/28713551/case-report-intramammary-lymph-node-metastasis-of-an-unknown-primary-probably-occult-breast-undifferentiated-carcinoma
#2
Zacharoula Sidiropoulou, Félix Adélia, Isabela Gil, Tobias Teles, Claudia Santos, Lucilia Monteiro
Little is known about the clinical importance of intramammary lymph node metastasis of breast cancer, even though it is not rare. In the present paper, the authors present an unusual, rare case of an intramammary lymph node metastasis of an unknown primary, probably occult breast cancer, and its management. The patient was submitted to various staging exams and surgical procedures and a definitive diagnosis was not established. From a multidisciplinary context, it was assumed that the patient had a breast triple negative primary with axillary involvement...
2017: F1000Research
https://www.readbyqxmd.com/read/28701542/group-iv-nociceptors-develop-axonal-chemical-sensitivity-during-neuritis-and-following-treatment-of-the-sciatic-nerve-with-vinblastine
#3
Rosann M Govea, Mary F Barbe, Geoffrey M Bove
We have previously shown that nerve inflammation (neuritis) and transient vinblastine application lead to axonal mechanical sensitivity in nociceptors innervating deep structures. We have also shown that these treatments reduce axonal transport, and proposed that this leads to functional accumulation of mechanically sensitive channels in the affected part of the axons. While informing the etiology of mechanically induced pain, axonal mechanical sensitivity does not address the common report of ongoing radiating pain during neuritis, which could be secondary to the provocation of axonal chemical sensitivity...
July 12, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28695521/the-use-of-parp-inhibitors-in-cancer-therapy-use-as-adjuvant-with-chemotherapy-or-radiotherapy-use-as-a-single-agent-in-susceptible-patients-and-techniques-used-to-identify-susceptible-patients
#4
Sydney Shall, Terry Gaymes, Farzin Farzaneh, Nicola J Curtin, Ghulam J Mufti
This chapter describes some of the techniques in use in our laboratories for the investigation of PARP inhibitors in clinical medicine. More specifically, we are involved in investigating the utility of PARP inhibitors in the treatment of hematopoietic malignancies. We are also actively investigating the properties of the PARP systems in cell biology. We begin the chapter with a very brief history of the invention and use of PARP inhibitors. We then explain the underlying logic of the use of PARP inhibitors either in combination with chemo- or radiotherapy or as single agents used alone...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28689368/maximize-surgical-resection-beyond-contrast-enhancing-boundaries-in-newly-diagnosed-glioblastoma-multiforme-is-it-useful-and-safe-a-single-institution-retrospective-experience
#5
Federico Pessina, Pierina Navarria, Luca Cozzi, Anna Maria Ascolese, Matteo Simonelli, Armando Santoro, Elena Clerici, Marco Rossi, Marta Scorsetti, Lorenzo Bello
The extent of surgical resection (EOR) has been recorded as conditioning outcome in glioblastoma multiforme (GBM) patients but no significant improvements were recorded in survival. The study aimed to evaluate the impact of EOR on survival, investigating the role of fluid-attenuated inversion recovery (FLAIR) abnormalities removal. 282 newly diagnosed GBM patients were treated with surgery followed by concurrent and adjuvant chemo-radiotherapy. The EOR was defined as: SUPr, in case of resection amounting to 100% of enhanced and FLAIR areas; gross total (GTR) in case of resection between 90 and 100% of enhanced areas with variable amount of FLAIR abnormalities; sub-total (STR), between 10 and 89%; biopsy (B) <10%...
July 8, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28685404/analysis-of-factors-influencing-the-access-to-concomitant-chemo-radiotherapy-in-elderly-patients-with-high-grade-gliomas-role-of-mmse-age-and-tumor-volume
#6
Andrea Di Cristofori, Barbara Zarino, Claudia Fanizzi, Giorgia Abete Fornara, Giulio Bertani, Paolo Rampini, Giorgio Carrabba, Manuela Caroli
High grade gliomas (HGG) are tumors with a rapidly progressive course and the standard of care consists of surgery and chemo-radiotherapy. Elderly patients with HGG usually have a worse prognosis due to their comorbidities and difficulties in accessing or completing adjuvant treatments. The purpose of our study was to assess the influence of pre-operative factors (MMSE, age, sex, KPS, tumor volume) on the post-operative access to chemo-radiotherapy in the elderly population. In addition, the influence of the access to adjuvant therapies on overall survival (OS) was assessed...
July 6, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28671758/comparison-of-mediastinal-lymph-node-status-and-relapse-pattern-in-clinical-stage-iiia-non-small-cell-lung-cancer-patients-treated-with-neoadjuvant-chemotherapy-versus-upfront-surgery-a-single-center-experience
#7
Milan Savic, Milica Kontic, Maja Ercegovac, Jelena Stojsic, Slavisa Bascarevic, Dejan Moskovljevic, Marko Kostic, Radomir Vesovic, Spasoje Popevic, Marija Laban, Jelena Markovic, Dragana Jovanovic
BACKGROUND: In spite of the progress made in neoadjuvant therapy for operable non small-cell lung cancer (NSCLC), many issues remain unsolved, especially in locally advanced stage IIIA. METHODS: Retrospective data of 163 patients diagnosed with stage IIIA NSCLC after surgery was analyzed. The patients were divided into two groups: a preoperative chemotherapy group including 59 patients who received platinum-etoposide doublet treatment before surgery, and an upfront surgery group including 104 patients for whom surgical resection was the first treatment step...
July 3, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28642179/analysis-of-outcomes-of-multidisciplinary-management-of-gliosarcoma-a-single-centre-study-2000-2013
#8
Abhinav Jain, Jason Correia, Patrick Schweder, Adele McMahon, Joseph Merola, Robert Aspoas
BACKGROUND: Gliosarcoma is a rare CNS tumour with a reported incidence of ∼2-8% of all gliomas. We reviewed the outcomes of patients treated at our institution over a 14-year period from 2000-2013 to characterize overall and progression free survival as well as to elucidate the additive effect of chemo-radiotherapy. METHODS: For the duration of 01/01/2000 to 31/12/2013, we retrospectively reviewed the clinical notes of all patients treated at our institution with a histopathological diagnosis of Gliosarcoma...
June 19, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28641310/potentiating-the-effects-of-radiotherapy-in-rectal-cancer-the-role-of-aspirin-statins-and-metformin-as-adjuncts-to-therapy
#9
K J Gash, A C Chambers, D E Cotton, A C Williams, M G Thomas
BACKGROUND: Complete tumour response (pCR) to neo-adjuvant chemo-radiotherapy for rectal cancer is associated with a reduction in local recurrence and improved disease-free and overall survival, but is achieved in only 20-30% of patients. Drug repurposing for anti-cancer treatments is gaining momentum, but the potential of such drugs as adjuncts, to increase tumour response to chemo-radiotherapy in rectal cancer, is only just beginning to be recognised. METHODS: A systematic literature search was conducted and all studies investigating the use of drugs to enhance response to neo-adjuvant radiation in rectal cancer were included...
July 11, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28604556/immunologic-response-elicited-in-breast-cancer-patients-receiving-a-neugcgm3-based-vaccine-as-adjuvant-therapy
#10
Anet Valdes-Zayas, Zuyen Gonzalez, Vladimir Mulens, Aliz M Vega, Kirenia Perez, Patricia Lorenzo-Luaces, Maria C Rubio, Anabely Estevez, Idelmis Curbelo, Luis E Fernandez, Tania Crombet, Zaima Mazorra
This study aimed to investigate the immunogenicity of a cancer vaccine consisting of the NeuGcGM3 ganglioside combined with the outer membrane protein complex of Neisseria meningitides to form very small size particles. The vaccine is administered together with Montanide ISA51, as adjuvant treatment for breast cancer patients. After surgical resection and standard first-line chemo/radiotherapy, breast cancer patients in stage II-III were enrolled in a phase III clinical trial and allocated into 2 strata, according to the number of positive lymph nodes [stratum I (0-3); stratum II (≥4)]...
June 9, 2017: Journal of Immunotherapy
https://www.readbyqxmd.com/read/28593036/disseminated-and-late-metastatic-disease-from-nasal-pit-leiomyosarcoma-after-radical-surgical-resection-case-report-of-a-singular-presentation-of-a-rare-disease
#11
Enrico Pinotti, Marta Sandini, Simone Famularo, Marta Jaconi, Fabrizio Romano, Luca Nespoli, Luca Gianotti
BACKGROUND: Leiomyosarcoma of the head and neck is a rare cancer with high local aggressiveness. Radical surgery and adjuvant treatment offer the best chance for cure, nonetheless 5-years recurrence rate remains high. Despite international guidelines are available for soft tissue sarcomas, no recommendations are specifically endorsed for leiomyosarcoma of the head and neck, due to the rarity of its presentation and consequently scarcity of data on long-term outcome. CASE PRESENTATION: A 50-year old woman, operated 10 years before for leiomyosarcoma of the nasal pit and with negative 5-years follow-up, was admitted to our ward for impairment of the hepatic function...
2017: Clinical Sarcoma Research
https://www.readbyqxmd.com/read/28578803/head-and-neck-cancer-cell-radiosensitization-upon-dual-targeting-of-c-abl-and-beta1-integrin
#12
Philipp Koppenhagen, Ellen Dickreuter, Nils Cordes
Integrin-mediated cell adhesion to extracellular matrix (ECM) critically contributes to cancer cell therapy resistance and DNA double strand break (DSB) repair. c-Abl tyrosine kinase has been linked to both of these processes. Based on our previous findings indicating c-Abl hyperphosphorylation on tyrosine (Y) 412 and threonine (T) 735 upon beta1-integrin inhibition, we hypothesized c-Abl tyrosine kinase as an important mediator of beta1-integrin signaling for radioresistance. In a panel of 8 cell lines from different solid cancer types grown in 3D laminin-rich ECM cultures, we targeted beta1 integrin with AIIB2 (mAb) and c-Abl with Imatinib with and without X-ray irradiation and subsequently examined clonogenic survival, residual DSBs, protein expression and phosphorylation...
May 31, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28578142/impact-of-lymph-node-ratio-in-selecting-patients-with-resected-gastric-cancer-for-adjuvant-therapy
#13
Yuhree Kim, Malcolm H Squires, George A Poultsides, Ryan C Fields, Sharon M Weber, Konstantinos I Votanopoulos, David A Kooby, David J Worhunsky, Linda X Jin, William G Hawkins, Alexandra W Acher, Clifford S Cho, Neil Saunders, Edward A Levine, Carl R Schmidt, Shishir K Maithel, Timothy M Pawlik
BACKGROUND: The impact of adjuvant chemotherapy and chemo-radiation therapy in the treatment of resectable gastric cancer remains varied. We sought to define the clinical impact of lymph node ratio on the relative benefit of adjuvant chemotherapy or chemo-radiation therapy among patients having undergone curative-intent resection for gastric cancer. METHODS: Using the multi-institutional US Gastric Cancer Collaborative database, 719 patients with gastric adenocarcinoma who underwent curative-intent resection between 2000 and 2013 were identified...
August 2017: Surgery
https://www.readbyqxmd.com/read/28555274/survival-analysis-of-287-oropharyngeal-squamous-cell-carcinoma-patients-in-a-single-institution-a-retrospective-comparison-of-two-consecutive-time-intervals-with-surgical-and-conservative-treatment-approaches
#14
Adrian Münscher, Lara Bussmann, Susanne Sehner, Simon Knaack, Alexandra Gliese, Silke Tribius, Till Clauditz, Balazs B Lörincz
This study is a retrospective analysis of clinico-pathological data to investigate survival rates of patients with oropharyngeal squamous cell carcinoma (OPSCC) treated with different modalities in a single academic head and neck cancer center in different time intervals. Altogether, 287 patients with OPSCC were included in this comparison. Patients were analysed during two different treatment periods: Group 1 included patients treated mainly with primary surgery ± adjuvant radio(chemo)therapy between 2002 and 2007, while Group 2 included patients treated with organ/function-preservation protocols if indicated...
August 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28553616/the-oncolytic-virotherapy-era-in-cancer-management-prospects-of-applying-h-1-parvovirus-to-treat-blood-and-solid-cancers
#15
Assia L Angelova, Mathias Witzens-Harig, Angel S Galabov, Jean Rommelaere
Non-Hodgkin lymphoma (NHL) and leukemia are among the most common cancers worldwide. While the treatment of NHL/leukemia of B-cell origin has much progressed with the introduction of targeted therapies, few treatment standards have been established for T-NHL/leukemia. As presentation in both B- and T-NHL/leukemia patients is often aggressive and as prognosis for relapsed disease is especially dismal, this cancer entity poses major challenges and requires innovative therapeutic approaches. In clinical trials, oncolytic viruses (OVs) have been used against refractory multiple myeloma (MM)...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28549344/metformin-increases-chemo-sensitivity-via-gene-downregulation-encoding-dna-replication-proteins-in-5-fu-resistant-colorectal-cancer-cells
#16
Sung-Hee Kim, Soon-Chan Kim, Ja-Lok Ku
Metformin is most widely prescribed for type 2 diabetes. Recently, evidences have shown that metformin has anticancer effects on pancreatic-, colorectal-, ovarian-, and other cancers. Because metformin has less adverse effects and is inexpensive, it could be a useful chemo-therapeutic agent with anticancer effects. In this study, we demonstrated metformin inhibited by cell proliferation, cell migration ability, clonogenic ability, and cancer stem cell population. Metformin also induced cell cycle arrest in parental-(SNU-C5), and 5-Fu resistant-colorectal cancer cell line (SNU-C5_5FuR)...
May 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28524247/comparison-of-adjuvant-therapy-for-node-positive-clinical-stage-ib-iib-cervical-cancer-systemic-chemotherapy-versus-pelvic-irradiation
#17
Koji Matsuo, Muneaki Shimada, Yoichi Aoki, Masaru Sakamoto, Nobuhiro Takeshima, Hisaya Fujiwara, Takashi Matsumoto, Mikio Mikami, Toru Sugiyama
This was a nation-wide retrospective study in Japan examining women who underwent radical hysterectomy for clinical stage IB-IIB cervical cancer with pelvic and/or para-aortic lymph node metastasis between 2004 and 2008. Time to recurrence or death and patterns of disease recurrence were compared based upon the adjuvant treatment pattern: whole pelvic radiotherapy alone (n = 253), concurrent chemoradiotherapy (CCRT, n = 502) and chemotherapy alone (n = 319). Women who received chemotherapy alone had similar recurrence (5-year rates, 36...
May 19, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28498431/prkdc-regulates-chemosensitivity-and-is-a-potential-prognostic-and-predictive-marker-of-response-to-adjuvant-chemotherapy-in-breast-cancer-patients
#18
Gang Sun, Le Yang, Chao Dong, Bin Ma, Meihui Shan, Binlin Ma
DNA-dependent kinase catalytic subunit (DNA-PKcs) is a critical component of DNA repair machinery and is found to be up- or down-regulated in different cancer types. However, its clinical significance in breast cancer remains unclear. To this end, quantitative PCR was performed to measure PRKDC expression level in 59 pairs of breast cancer tissues and the non-tumor adjacent tissues (NATs). The correlation between PRKDC expression and overall survival (OS) as well as the prognostic value of PRKDC were analyzed...
June 2017: Oncology Reports
https://www.readbyqxmd.com/read/28498252/completing-or-abandoning-radical-hysterectomy-in-early-stage-lymph-node-positive-cervical-cancer-impact-on-disease-free-survival-and-treatment-related-toxicity
#19
Marloes Derks, Freek A Groenman, Luc R C W van Lonkhuijzen, Paulien C Schut, Henrike Westerveld, Jacobus van der Velden, Gemma G Kenter
INTRODUCTION: Management regarding completing hysterectomy in case of intraoperative finding of positive lymph nodes in early-stage cervical cancer differs between institutions. The aim of this study was to compare survival and toxicity after completed hysterectomy followed by adjuvant (chemo-)radiotherapy versus abandoned hysterectomy and primary treatment with chemoradiotherapy (CRT). METHODS: A retrospective multicenter cohort study was performed. All patients were scheduled for radical hysterectomy with pelvic lymphadenectomy (RHL)...
June 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28495443/dose-volume-correlation-of-cumulative-vaginal-doses-and-late-toxicity-after-adjuvant-external-radiation-and-brachytherapy-for-cervical-cancer
#20
Roshni Singh, Supriya Chopra, Reena Engineer, Siji Paul, Sadhana Kannan, Sarthak Mohanty, Jamema Swamidas, Umesh Mahantshetty, Jaya Ghosh, Amita Maheshwari, T Surappa Shylasree, Rajendra Kerkar, Sudeep Gupta, Shyam Shrivastava
PURPOSE: To investigate dose-response relationship between vaginal doses and long-term morbidity. METHODS AND MATERIALS: Patients receiving adjuvant pelvic (chemo) radiation and brachytherapy for cervical cancer from January 2011 to December 2014 were included. Baseline vaginal length was determined clinically and from imaging at BT planning. Dose points were defined along mucosa and at 5 mm depth at 12, 3, 6, and 9 'o' clock positions at every 2 cm from apex to introitus...
May 8, 2017: Brachytherapy
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