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https://www.readbyqxmd.com/read/29313371/utility-of-3-month-surveillance-f-18-fdg-pet-ct-in-surgically-resected-oral-squamous-cell-carcinoma
#1
Michael Marquardt, Carryn Anderson, Timothy Ginader, Jessica Parkhurst, Nitin Pagedar, Rodrigo Bayon, Gerald Clamon, Andrew Hoover, John Buatti
OBJECTIVES: To evaluate the performance of surveillance F-18 fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) 1 year after imaging in oral squamous cell carcinoma (OSCC) patients treated with definitive surgery and adjuvant (chemo)radiotherapy (RT). METHODS AND MATERIALS: Surveillance PET/CT accuracy was retrospectively evaluated in OSCC patients receiving surgical resection and (chemo)RT. Pathologic risk factors were assessed for influence on accuracy of the post-RT PET/CT...
January 1, 2018: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/29290995/effectiveness-of-adjuvant-systemic-chemotherapy-for-intermediate-risk-stage-ib-cervical-cancer
#2
Koji Matsuo, Muneaki Shimada, Harushige Yokota, Toyomi Satoh, Hidetaka Katabuchi, Shoji Kodama, Hiroshi Sasaki, Noriomi Matsumura, Mikio Mikami, Toru Sugiyama
Objective: To examine the effectiveness of systemic chemotherapy following radical hysterectomy for women with intermediate-risk stage IB cervical cancer. Materials and Methods: This is a retrospective analysis of a previously organized nation-wide cohort study examining 6,003 women with stage IB-IIB cervical cancer who underwent radical hysterectomy between 2004 and 2008 in Japan. Survival of 555 women with stage IB cervical cancer in the intermediate-risk group (deep stromal invasion > 50%, large tumor size > 4 cm, and lympho-vascular space invasion [LVSI]) were examined based on adjuvant therapy patterns: chemotherapy alone (n = 223, 40...
December 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/29280498/precision-porous-templated-scaffolds-of-varying-pore-size-drive-dendritic-cell-activation
#3
Ruying Chen, Hongyan Ma, Lei Zhang, James D Bryers
Scaffold based systems have shown significant potential in modulating immune responses in vivo. While there has been much attention on macrophage interactions with tissue engineered scaffolds for tissue regeneration, fewer studies have looked at the effects of scaffold design on the response of immune cells - i.e., dendritic cells (DCs). Here we present the effects of varying pore size of poly (2-hydroxyethyl methacrylate) (pHEMA) and poly(dimethylsiloxane) (PDMS, silicone) scaffolds on the maturation and in vivo enrichment of DCs...
December 27, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29277755/our-ace-in-the-hole-justifying-the-use-of-angiotensin-converting-enzyme-inhibitors-as-adjuvants-to-standard-chemotherapy
#4
REVIEW
Daniel P Radin, Austin Krebs, Arman Maqsudlu, Parth Patel
Angiotensin-I-converting enzyme (ACE) inhibitors have been very effective in treating cardiac hypertension since their clinical inception over four decades ago. Since then, it has been established that angiotensin II, the product of ACE, has oncogenic and pro-proliferative qualities, which begs the question as to whether ACE inhibitors may have oncolytic characteristics. In fact, scattered reports suggest that ACE inhibitors are oncolytic and oncopreventive, but the available literature has yet to be thoroughly examined...
January 2018: Anticancer Research
https://www.readbyqxmd.com/read/29235000/is-neoadjuvant-therapy-sufficient-in-resected-pancreatic-cancer-patients-a-national-study
#5
Susanna W L de Geus, Gyulnara G Kasumova, Mariam F Eskander, Sing Chau Ng, Tara S Kent, A James Moser, Alexander L Vahrmeijer, Mark P Callery, Jennifer F Tseng
BACKGROUND: Despite the increasing use of neoadjuvant treatment, the question of whether preoperatively treated, successfully resected patients should receive additional postoperative adjuvant treatment remains unanswered. We evaluate the impact of adjuvant therapy following neoadjuvant treatment and pancreatectomy in pancreatic cancer patients in a large national study. METHODS: We used the National Cancer Data Base between 2006 and 2013 to identify resected, non-metastatic pancreatic adenocarcinoma patients who received neoadjuvant chemo(radio)therapy followed by pancreatectomy...
October 4, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29224815/definitive-chemo-radiotherapy-is-a-curative-alternative-for-standard-of-care-in-advanced-stage-squamous-cell-carcinoma-of-the-oral-cavity
#6
Joris B W Elbers, Abrahim Al-Mamgani, Danique Paping, Michiel W M van den Brekel, Katarzyna Jóźwiak, J P de Boer, Baris Karakullukcu, Marcel Verheij, Charlotte L Zuur
OBJECTIVE: To compare outcome after definitive (chemo)radiotherapy (CRT group) with standard of care (surgery group) for advanced stage oral cavity carcinoma (OCC). Although definitive (chemo)radiotherapy is assumed to be inferior to surgery with regard to disease control, data on outcome of this approach are scarce. METHODS: Retrospective analysis by chart review (2000-2013). Endpoints were locoregional control (LRC), disease-free survival (DFS), disease specific survival (DSS) and overall survival (OS)...
December 2017: Oral Oncology
https://www.readbyqxmd.com/read/29223846/clinical-features-and-surgical-outcomes-of-pulmonary-artery-sarcoma
#7
Kanhua Yin, Zhiqi Zhang, Rongkui Luo, Yuan Ji, Difan Zheng, Yi Lin, Chunsheng Wang
OBJECTIVE: Pulmonary artery sarcoma is an exceedingly rare malignancy. There is a lack of consensus regarding its diagnosis and treatment. We reviewed our experience in the surgical management of pulmonary artery sarcoma over an 11-year period. METHODS: From January 2005 to February 2016, 12 patients with pulmonary artery sarcoma (age 51 ± 14 years, 5 male) underwent surgical treatment at our center. Nine patients (75%) exhibited pulmonary trunk involvement on computed tomography angiography...
November 10, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29201450/the-role-of-surgery-in-high-grade-neuroendocrine-tumours-of-the-lung
#8
Stefan Welter, Clemens Aigner, Christian Roesel
High grade lung neuroendocrine tumours are a heterogeneous subtype of pulmonary cancers including small cell lung cancer (SCLC) and large-cell neuroendocrine carcinoma (LCNEC). LCNEC represents approximately 2-3% of lung cancers, whereas SCLC represents 15-20% of lung cancers. Patients with SCLC and LCNEC have a poor prognosis compared with patients with non-small cell lung cancer (NSCLC). LCNEC is treated with primary surgical resection in stages I-II, which is similar to other NSCLCs. Neo-adjuvant treatment in stage III is similar to NSCLC but has not been well studied...
November 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29199658/an-audit-and-analysis-of-different-causes-of-defaults-in-patients-receiving-radiation-for-head-and-neck-cancers-a-tertiary-regional-cancer-center-experience
#9
L Pujari, S Padhi, P Meher, A Tripathy
CONTEXT: Strict adherence and timely completion of the external beam radiation therapy (EBRT) schedule is an important prognostic factor in the survival of head and neck cancer patients. However, many patients are unable to complete the radiation treatment due to various reasons resulting in a poor outcome. AIMS: This study aims to study the pattern and various possible causes of defaults for possible intervention. SETTINGS AND DESIGN: A retrospective epidemiological analysis...
January 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29187906/the-changing-therapeutic-role-of-chemo-radiotherapy-for-loco-regionally-advanced-nasopharyngeal-carcinoma-from-two-three-dimensional-radiotherapy-to-intensity-modulated-radiotherapy-a-network-meta-analysis
#10
Rui You, Ying-Shu Cao, Pei-Yu Huang, Lei Chen, Qi Yang, You-Ping Liu, Xiong Zou, Yi-Nuan Zhang, Rou Jiang, Meng-Xia Zhang, Chong-Yang Duan, Ai-Hua Lin, Ming-Huang Hong, Ming-Yuan Chen
Purpose: We used randomized trials of radiotherapy (RT) with or without chemotherapy in non-metastatic nasopharyngeal carcinoma to investigate the survival benefit of chemoradiotherapy regimens between two/three-dimensional radiotherapy (2D/3D RT) and intensity-modulated radiotherapy (IMRT). Methods: Overall, 27 trials and 7,940 patients were included. Treatments were grouped into seven categories including RT alone, induction chemotherapy (IC) followed by RT (IC-RT), RT followed by adjuvant chemotherapy (RT-AC), IC followed by RT followed by AC (IC-RT-AC), concurrent chemo-radiotherapy (CRT), IC followed by CRT (IC-CRT), and CRT followed by AC (CRT-AC)...
2017: Theranostics
https://www.readbyqxmd.com/read/29187460/adjuvant-breast-cancer-treatments-induce-changes-in-homoarginine-level-a-prospective-observational-study
#11
Hanna Aula, Tanja Skyttä, Suvi Tuohinen, Tiina Luukkaala, Mari Hämäläinen, Vesa Virtanen, Pekka Raatikainen, Eeva Moilanen, Pirkko-Liisa Kellokumpu-Lehtinen
AIM: To identify patients with breast cancer at risk for cardiotoxicity, we evaluated homoarginine (HA) behavior during adjuvant treatment. PATIENTS AND METHODS: Eighty-one patients received radiotherapy (RT) with or without endocrine treatment, and 19 received chemotherapy, RT and endocrine therapy. Serum HA, asymmetric dimethylarginine (ADMA) and high-sensitivity cardiac troponin T (hscTnT) were measured and echocardiography was performed before chemotherapy, and before and after RT...
December 2017: Anticancer Research
https://www.readbyqxmd.com/read/29186937/how-to-use-pet-ct-in-the-evaluation-of-response-to-radiotherapy
#12
Pierre Decazes, Sébastien Thureau, Bernard Dubray, Pierre Vera
INTRODUCTION: Radiotherapy is a major treatment modality for many cancers. Tumor response after radiotherapy determines the subsequent steps of the patient's management (surveillance, adjuvant or salvage treatment and palliative care). Tumor response assessed during radiotherapy offers a promising opportunity to adapt the treatment plan to reduced / increased target volume, to specifically target sub-volumes with relevant biological characteristics (metabolism, hypoxia, proliferation ...
November 28, 2017: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29159744/treatment-and-outcome-of-synchronous-colorectal-carcinomas-a-nationwide-study
#13
A C R K Bos, R A Matthijsen, F N van Erning, M G H van Oijen, H J T Rutten, V E P P Lemmens
BACKGROUND: Synchronous colorectal carcinomas (CRC) occur in 1-8% of patients diagnosed with CRC. This study evaluated treatment patterns and patient outcomes in synchronous CRCs compared with solitary CRC patients. METHODS: All patients diagnosed with primary CRC between 2008 and 2013, who underwent elective surgery, were selected from the Netherlands Cancer Registry. Using multivariable regressions, the effects of synchronous CRC were assessed for both short-term outcomes (prolonged postoperative hospital admission, anastomotic leakage, postoperative 30-day mortality, administration of neoadjuvant or adjuvant treatment), and 5-year relative survival (RS)...
November 20, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29154508/primary-gliosarcoma-epidemiology-clinical-presentation-management-and-survival
#14
Ruichong Ma, Delia-Marina Alexe, Davide Boeris, Erlick Pereira
Gliosarcomas are malignant tumours of the central nervous system. As glioblastomas (GBM), they are treated in a similar fashion. However there is growing evidence to suggest that they may be a separate entity. Due to the rarity of primary gliosarcomas (PGS)Here we publish single centre data over a 14-year period, comprising possibly one of the biggest case series in the literature to our knowledge. The mean age at presentation was 59 years with male preponderance (1.75:1). The most common presenting symptoms were balance and mobility issues (61%), followed by headaches (50%) and visual problems (39%)...
November 20, 2017: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/29137426/therapeutic-implications-of-tumor-free-margins-in-head-and-neck-squamous-cell-carcinoma
#15
Clara Backes, Henning Bier, Andreas Knopf
Objectives: The resection status is one of the most important prognostic factors for patients with head and neck squamous cell carcinoma (HNSCC) concerning overall survival (OS) and recurrence free interval (RFI). To assess whether therapy concepts changed depending on different resection margins and extracapsular extension, OS and RFI data were set into clinical context. Methods: All HNSCC patients who underwent head and neck surgery with/without adjuvant therapy (n=534) were selected over a ten-year period (2001-2011)...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29132875/aspirin-use-and-endometrial-cancer-risk-and-survival
#16
REVIEW
Tsuyoshi Takiuchi, Erin A Blake, Koji Matsuo, Anil K Sood, Theodore M Brasky
The role of acetylsalicylic acid (aspirin) as a chemo-preventive and adjuvant therapeutic agent for cancers is generating attention. Mounting evidence indicates that aspirin reduces the incidence and mortality of certain obesity-related cancers, particularly colorectal cancer. In endometrial cancer, previous studies examining the effect of aspirin remain inconsistent as to the reduction in the risk of endometrial cancer. While some evidence indicates protective effects in obese women, other studies have showed a potential deleterious effect of these medications on endometrial cancer outcomes...
November 10, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29118718/the-practice-of-physical-activity-in-the-setting-of-lower-extremities-sarcomas-a-first-step-toward-clinical-optimization
#17
Mohamad Assi, Mickael Ropars, Amélie Rébillard
Lower-extremities sarcoma patients, with bone tumor and soft-tissue sarcoma, are a unique population at high risk of physical dysfunction and chronic heart diseases. Thus, providing an adequate physical activity (PA) program constitutes a primary part of the adjuvant treatment, aiming to improve patients' quality of life. The main goal of this paper is to offer clear suggestions for clinicians regarding PA around the time between diagnosis and offered treatments. These preliminary recommendations reflect our interpretation of the clinical and preclinical data published on this topic, after a systematic search on the PubMed database...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29103238/neo-adjuvant-chemo-radiation-to-60-gray-followed-by-surgery-for-locally-advanced-non-small-cell-lung-cancer-patients-evaluation-of-trimodality-strategy
#18
Sarit Appel, Jeffry Goldstein, Marina Perelman, Tatiana Rabin, Damien Urban, Amir Onn, Tiberiu R Shulimzon, Ilana Weiss, Sivan Lieberman, Edith M Marom, Nir Golan, David Simansky, Alon Ben-Nun, Yaacov Richard Lawrence, Jair Bar, Zvi Symon
BACKGROUND: Neoadjuvant chemo-radiation therapy (CRT) dosages in locally advanced non-small cell lung cancer (NSCLC) were traditionally limited to 45 Gray (Gy). OBJECTIVES: To retrospectively analyze outcomes of patients treated with 60 Gy CRT followed by surgery. METHODS: A retrospective chart review identified patients selected for CRT to 60 Gy followed by surgery between August 2012 and April 2016. Selection for surgery was based on the extent of disease, cardiopulmonary function, and response to treatment...
October 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29083507/complications-and-donor-site-morbidity-of-3-layer-reconstruction-with-iliotibial-tract-of-the-anterior-skull-base-retrospective-analysis-of-186-patients
#19
Davide Mattavelli, Alberto Schreiber, Andrea Bolzoni Villaret, Remo Accorona, Mario Turri-Zanoni, Alessia Lambertoni, Marco Ferrari, Paolo Castelnuovo, Piero Nicolai
BACKGROUND: Anterior skull base reconstruction after resection of sinonasal cancers may be challenging when pedicled flaps are unavailable. The purpose of the present study was to analyze the complication rate and donor site morbidity of 3-layer reconstruction with the iliotibial tract (ITT). METHODS: We retrospectively reviewed all anterior skull base reconstructions with ITT performed from 2007 to 2015. Donor site morbidity was investigated by a dedicated questionnaire...
October 30, 2017: Head & Neck
https://www.readbyqxmd.com/read/29081843/clinical-staging-of-nsclc-current-evidence-and-implications-for-adjuvant-chemotherapy
#20
REVIEW
David J Heineman, Johannes M Daniels, Wilhelmina H Schreurs
Survival of all non-small cell lung cancer (NSCLC) patients is disappointing, with a 5-year survival of 18%. Staging NSCLC patients is crucial because it determines the choice of treatment and prognosis. Clinical staging is a complex process that comes with many challenges and with low accuracy between the clinical and pathological stage. Treatment modalities for stage I-III NSCLC consist of surgical resection, radiotherapy and chemotherapy. This review describes the current evidence on staging and the implications on adjuvant chemotherapy...
September 2017: Therapeutic Advances in Medical Oncology
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