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https://www.readbyqxmd.com/read/29754426/venous-thromboembolism-in-cancer-patients-receiving-neoadjuvant-chemotherapy-a-systematic-review-and-meta-analysis
#1
M Di Nisio, M Candeloro, A W S Rutjes, E Porreca
BACKGROUND: Venous thromboembolism (VTE) is a frequent complication in cancer patients receiving adjuvant treatment. The risk of VTE during neoadjuvant chemo-radiotherapy remains unclear. OBJECTIVES: This systematic review evaluated the incidence of VTE in patients with cancer receiving neoadjuvant treatment. METHODS: MEDLINE and EMBASE databases were searched from inception to October 2017. Search results were supplemented with screening of conference proceedings of the American Society of Clinical Oncology (2009-2016) and the International Society of Thrombosis and Haemostasis (2003-2016)...
May 13, 2018: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29748448/health-related-quality-of-life-in-oropharyngeal-cancer-survivors-a-population-based-study
#2
Thomas Guenzel, U Walliczek-Dworschak, A Teymoortash, S Singer, M Eichler, T Wilhelm, M Schimmer, A Franzen
OBJECTIVE: The aim of this study was to compare QoL of oropharyngeal cancer survivors who had received different treatments. SUBJECTS AND METHODS: We contacted 954 survivors. Each survivor received the QoL questionnaires EORTC QLQ-C30 and EORTC QLQ-H&N35. RESULTS: A total of 263 survivors completed the questionnaires (28% responses). Forty-five of them had undergone surgery, 20 had received definitive radiotherapy or chemo-radiotherapy, 85 surgery plus adjuvant radiotherapy, and 111 surgery plus adjuvant chemo-radiotherapy...
April 30, 2018: Otolaryngologia Polska
https://www.readbyqxmd.com/read/29745931/-mitomycin-c-hivec-update-and-results-in-high-risk-patients
#3
Félix Guerrero-Ramos, Daniel Castellano-Gauna, Esther García-Rojo, José Manuel Duarte-Ojeda, Federico de la Rosa-Kehrmann, Felipe Villacampa-Aubá
Adjuvant endovesical treatment is a research field in constant exploration with the aim to minimize the risk of recurrence and progression of non muscle invasive bladder tumors. Over the last years, the administration of chemotherapy in a chemo hyperthermia regimen has been added to the existing regimens. There are various systems for its administration, but this article focus on HIVEC (Hyperthermic IntraVEsical Chemotherapy) and its current status. In this review article we update the results of this system in the case-scenarios it has been used (preoperative with ablative intention and as adjuvant therapy with prophylactic purposes), tolerance and security issues, on-going clinical trials and future perspectives...
May 2018: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/29731124/corrigendum-to-endoscopic-resection-with-adjuvant-chemo-radiotherapy-for-superficial-esophageal-squamous-cell-carcinoma-a-critical-review-crit-rev-oncol-hematol-124-april-2018-61-65
#4
Tsz Yeung Kam, Melpomeni Kountouri, Arnaud Roth, Jean-Louis Frossard, Olivier Huber, Stefan Mönig, Thomas Zilli
No abstract text is available yet for this article.
May 3, 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29697193/solid-pseudopapillary-and-malignant-pancreatic-tumors-in-childhood-a-systematic-review-and-evidence-quality-assessment
#5
REVIEW
Konstantinos S Mylonas, Ilias P Doulamis, Diamantis I Tsilimigras, Dimitrios Nasioudis, Dimitrios Schizas, Peter T Masiakos, Cassandra M Kelleher
A systematic review of 32 studies reporting on 489 children with pancreatic tumors was performed. The most prevalent histologic subtype was solid pseudopapillary tumor (SPT) (61.3%). Pancreaticoduodenectomy was the most commonly performed operation (48%). Neoadjuvant chemo/radiotherapy was utilized in 3.9, 36.2, 25, and 27.8% of patients with SPTs, pancreatoblastomas (PBLs), neuroendocrine tumors, and exocrine carcinomas, respectively. Adjuvant chemotherapy (75.6%) and radiation (34%) were most commonly utilized in PBLs...
April 26, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29682708/-early-diagnosis-and-treatment-of-anastomotic-leak-after-rectal-cancer-surgery
#6
Tinghan Yang, Ziqiang Wang
Anastomotic leakage is the most common major complication after mid-low rectal cancer surgery. Due to lack of knowledge regarding the virtual mechanisms of anastomotic leakage, not much can be done to prevent its development. The aim of the present review was to discuss the prevention, early diagnosis, and treatment of anastomotic leakage after rectal cancer surgery. For patients with risk factors, such as anastomotic site within 4 cm from anus, obese men, lack of blood supply of the anastomotic site, neoadjuvant chemo radiotherapy, or patients with severe co-morbidity, aggressive preventive strategy should be adopted...
2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29668359/laparoscopic-total-mesorectal-excision-following-transanal-endoscopic-microsurgery-for-rectal-cancer
#7
Nidal Issa, Yaniv Fenig, Rachel Gingold-Belfer, Muhammad Khatib, Wisam Khoury, Lea Wolfson, Hemda Schmilovitz-Weiss
BACKGROUND: Patients' selection for transanal endoscopic microsurgery (TEM) depends on diagnostic modalities; however, there are still some limitations in the preoperative diagnosis of rectal lesions, and in some reports, up to third of the adenomas resected by TEM were found to be adenocarcinoma; therefore, salvage radical resection (RR) remains necessary for achieving oncological resection. Salvage RR may encounter some technical problems as the violation of the mesorectum and the scar formation...
April 18, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29615067/does-setup-on-rectal-wall-improve-rectal-cancer-boost-radiotherapy
#8
Jean-Paul J E Kleijnen, Bram van Asselen, Martijn Intven, Johannes P M Burbach, Marielle E P Philippens, Jan J W Lagendijk, Bas W Raaymakers
BACKGROUND: Rectal cancer patients that show a pathological complete response (pCR) after neo-adjuvant chemo-radiotherapy, have better prognosis. To increase pCR rates several studies escalate the tumor irradiation dose. However, due to lacking tumor contrast on online imaging techniques, no direct tumor setup can be performed and large boost margins are needed to ensure tumor coverage. The purpose of this study was to evaluate the feasibility of performing a setup on rectal wall for rectal cancer boost radiotherapy, thereby using rectal wall nearby the tumor as tumor position surrogate...
April 4, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29605476/estro-acrop-guidelines-for-target-volume-definition-in-the-treatment-of-locally-advanced-non-small-cell-lung-cancer
#9
Ursula Nestle, Dirk De Ruysscher, Umberto Ricardi, Xavier Geets, Jose Belderbos, Christoph Pöttgen, Rafal Dziadiuszko, Stephanie Peeters, Yolande Lievens, Coen Hurkmans, Ben Slotman, Sara Ramella, Corinne Faivre-Finn, Fiona McDonald, Farkhad Manapov, Paul Martin Putora, Cécile LePéchoux, Paul Van Houtte
Radiotherapy (RT) plays a major role in the curative treatment of locally advanced non-small cell lung cancer (NSCLC). Therefore, the ACROP committee was asked by the ESTRO to provide recommendations on target volume delineation for standard clinical scenarios in definitive (chemo)radiotherapy (RT) and adjuvant RT for locally advanced NSCLC. The guidelines given here are a result of the evaluation of a structured questionnaire followed by a consensus discussion, voting and writing procedure within the committee...
March 28, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29582686/the-effects-of-radiotherapy-on-the-survival-of-patients-with-unresectable-non-small-cell-lung-cancer
#10
Paolo Tini, Valerio Nardone, Pierpaolo Pastina, Luigi Pirtoli, Pierpaolo Correale, Antonio Giordano
Lung cancer represents the leading cause of cancer mortality across the worlds. At present, less than 30% of the patients can undergo curative surgery, while the majority of them (65%) are diagnosed with metastatic disease and directed to systemic treatments whose effects on the outcome of these patients depends by their performance status, disease-stage, histology, targetable-driving-mutation, and susceptibility to immunotherapy. In this context there is a subset of patients (25%) with locally advanced stage disease whose outcome might be greatly improved by using combined strategies of treatment including chemotherapy, radiotherapy and surgery...
March 27, 2018: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/29582537/prognostic-value-of-tumour-regression-grade-in-locally-advanced-rectal-cancer-a-systematic-review-and-meta-analysis
#11
REVIEW
Joseph C Kong, Glen R Guerra, Satish K Warrier, A Craig Lynch, Michael Michael, Samuel Y Ngan, Wayne Phillips, G Ramsay, Alexander G Heriot
BACKGROUND: The current standard of care for locally advanced rectal cancer involves neo-adjuvant chemo-radiotherapy followed by total mesorectal excision. There is a spectrum of response to neo-adjuvant therapy, however the prognostic value of tumour regression grade(TRG) in predicting disease-free survival (DFS) or overall survival (OS) is inconsistent in the literature. METHODS: This study was performed in accordance with the PRISMA guidelines. A systematic search was undertaken using Ovid Medline, Embase and Google Scholar...
March 27, 2018: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/29580733/the-administration-of-adjuvant-chemo-immuno-therapy-in-the-post-acosog-z0011-era-a-population-based-study
#12
Ingrid G M Poodt, Marjolijn L Rots, Guusje Vugts, Thijs van Dalen, Anne Kuijer, Birgit E P J Vriens, Grard A P Nieuwenhuijzen, Robert-Jan Schipper
PURPOSE: The ACOSOG-Z0011-study has resulted in a trend to a more conservative treatment of the axilla for selected sentinel-node-positive patients. However, axillary nodal involvement has always been an important factor for tumor staging and tailoring adjuvant chemotherapy plans. This study evaluates the impact of omitting completion axillary lymph node dissection (cALND) on the administration of adjuvant chemo (-immuno)therapy in Dutch clinical T1-2N0M0 (cT1-2N0M0) sentinel-node-positive breast cancer patients...
March 14, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29573568/targeting-lmw-ptp-to-sensitize-melanoma-cancer-cells-toward-chemo-and-radiotherapy
#13
Giulia Lori, Paolo Paoli, Anna Caselli, Paolo Cirri, Riccardo Marzocchini, Monica Mangoni, Cinzia Talamonti, Lorenzo Livi, Giovanni Raugei
Tumor resistance to apoptosis is one the main causes of anticancer treatment failure. Previous studies showed that LMW-PTP overexpression enhances resistance of cancer cells to traditional anticancer drugs. Today, the role of LMW-PTP in inducing resistance to apoptosis in melanoma cells remains to be elucidated. Experimental setting include MTT assay, Annexin V/Pi method, and colony assay to assess whether silencing of LMW-PTP improves the sensitivity of A375 to dacarbazine, 5-FU, and radiotherapy. Pharmacological targeting of LMW-PTP was obtained using Morin, a LMW-PTP inhibitor...
March 24, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29560639/a-single-center-experience-in-resectable-pancreatic-ductal-adenocarcinoma-the-limitations-of-the-surgery-first-approach-critical-review-of-the-literature-and-proposals-for-practice-update
#14
R Dumont, F Puleo, J Collignon, N Meurisse, M Chavez, L Seidel, P Gast, M Polus, C Loly, Ph Delvenne, P Meunier, R Hustinx, A Deroover, O Detry, E Louis, Ph Martinive, D Van Daele
BACKGROUND AND STUDY AIMS: The current standard of care for resectable pancreatic ductal adenocarcinoma (PDAC) is surgery-first followed by adjuvant chemotherapy. We review our single center experience in a PDAC cohort managed by the surgery-first strategy. We then compare our data to those of Belgian and international literature. PATIENTS METHODS: We reviewed a series of 83 consecutive resectable patients with PDAC, treated by the surgery-first approach in a Belgian Academic Hospital between 2007 and 2013...
October 2017: Acta Gastro-enterologica Belgica
https://www.readbyqxmd.com/read/29548487/endoscopic-resection-with-adjuvant-chemo-radiotherapy-for-superficial-esophageal-squamous-cell-carcinoma-a-critical-review
#15
REVIEW
Tsz Yeung Kam, Melpomeni Kountouri, Arnaud Roth, Jean-Louis Frossard, Olivier Huber, Stefan Mönig, Thomas Zilli
Radical esophagectomy with extended lymph node dissection is considered the standard of care in treatment of squamous cell carcinoma of esophagus with deep mucosal invasion (pT1a m3) or submucosal involvement (pT1b). However, despite the increasing use of minimally invasive approaches, it remains a major surgery associated with significant morbidities and even mortality risk. Endoscopic resection (ER) results in excellent local control in early superficial mucosal (pT1a) disease yet there is substantial risk of lymph node metastases in T1b disease...
April 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29533009/albumin-to-fibrinogen-ratio-as-a-promising-biomarker-to-predict-clinical-outcome-of-non-small-cell-lung-cancer-individuals
#16
Shu-Qi Li, Yu-Huan Jiang, Jin Lin, Jing Zhang, Fan Sun, Qiu-Fang Gao, Lei Zhang, Qing-Gen Chen, Xiao-Zhong Wang, Hou-Qun Ying
Chronic inflammation is one of the critical causes to promote the initiation and metastasis of solid malignancies including lung cancer (LC). Here, we aimed to investigate the prognostic roles of albumin (Alb)-to-fibrinogen (Fib) ratio (AFR), Fib and Alb in LC and to establish a novel effective nomogram combined with AFR. Four hundred twelve LC patients diagnosed between February 2005 and December 2014 were recruited in this prospective study. The prognostic roles of AFR, Fib, Alb, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and monocyte-to-lymphocyte ratio (MLR) were identified by X-tile software, Kaplan-Meier curve, Cox regression model, and time-dependent ROC...
March 13, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29530393/chemotherapy-and-targeted-therapy-in-the-management-of-cervical-cancer
#17
REVIEW
Lalit Kumar, P Harish, Prabhat S Malik, S Khurana
Management of cervical cancer has undergone refinement in the past two decades; concurrent chemo-radiation (CCRT) (with cisplatin alone or in combination) is currently the standard treatment approach for patients with locally advanced disease (FIGO stage IIB-IVA). About 30%-40% of such patients fail to achieve complete response; alternative approaches are needed to improve outcome for them. Treatment with bevacizumab (an inhibitor of vascular endothelial growth factor) along with chemotherapy is associated with improved survival in patients with recurrent or metastatic cervical cancer...
February 3, 2018: Current Problems in Cancer
https://www.readbyqxmd.com/read/29525720/targeting-metabotropic-glutamate-receptors-in-the-treatment-of-primary-brain-tumors
#18
REVIEW
Luisa Iacovelli, Rosamaria Orlando, Alessandro Rossi, Paola Spinsanti, Daniela Melchiorri, Ferdinando Nicoletti
In spite of the recent advancement in the molecular characterization of malignant gliomas and medulloblastomas, the treatment of primary brain tumors remains suboptimal. The use of small molecule inhibitors of intracellular signaling pathways, inhibitors of angiogenesis, and immunotherapic agents is limited by systemic adverse effects, limited brain penetration, and, in some cases, lack of efficacy. Thus, adjuvant chemo-therapy and radiotherapy still remain the gold standard in the treatment of grade-IV astrocytoma (glioblastoma multiforme) and medulloblastoma...
February 2018: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/29496065/neck-recurrence-in-clinically-node-negative-oral-cancer-27-year-experience-at-a-single-institution
#19
Aviram Mizrachi, Jocelyn C Migliacci, Pablo H Montero, Sean McBride, Jatin P Shah, Snehal G Patel, Ian Ganly
OBJECTIVES: Neck failure in patients with oral squamous cell carcinoma (OSCC) carries a poor outcome, yet the management of patients who initially present with clinically node-negative (cN0) neck is not clearly defined. PATIENTS AND METHODS: Retrospective review of patients with cN0 OSCC treated at Memorial Sloan Kettering Cancer Center from 1985 to 2012, focusing on rate, pattern and predictors of neck failure, salvage treatment, and survival outcomes. RESULTS: Of 1,302 patients, 806 (62%) underwent elective neck dissection (END) and 496 (38%) had observation...
March 2018: Oral Oncology
https://www.readbyqxmd.com/read/29462493/short-delay-in-initiation-of-radiotherapy-for-patients-with-glioblastoma-effect-of-concurrent-chemotherapy-a-secondary-analysis-from-the-nrg-oncology-radiation-therapy-oncology-group-rtog-database
#20
Deborah T Blumenthal, Minhee Won, Minesh P Mehta, Mark R Gilbert, Paul D Brown, Felix Bokstein, David G Brachman, Maria Werner-Wasik, Grant K Hunter, Egils Valeinis, Kirsten Hopkins, Luis Souhami, Steven P Howard, Frank S Lieberman, Dennis C Shrieve, Merideth M Wendland, Cliff G Robinson, Peixin Zhang, Benjamin W Corn
Background: We previously reported the unexpected finding of significantly improved survival for newly-diagnosed glioblastoma patients when radiation therapy (RT) was initiated later (>4 weeks post-op) compared to earlier (≤2 weeks post-op). In that analysis, data were analyzed from 2855 patients from 16 NRG Oncology/RTOG trials conducted prior to the era of concurrent temozolomide (TMZ) with RT. We now report on 1395 newly-diagnosed glioblastoma patients from two studies, treated with RT and concurrent TMZ followed by adjuvant TMZ...
February 15, 2018: Neuro-oncology
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