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Diabetic retinopathy and nutrition

Daniel L Chao, Shuai-Chun Lin, Rebecca Chen, Shan C Lin
PURPOSE: Diabetic retinopathy is a major cause of irreversible vision loss. Recent studies have suggested that myopia may be negatively correlated with the prevalence of diabetic retinopathy. We sought to further investigate the association between refractive error and the likelihood of having diabetic retinopathy in a cross-sectional, population-based study of the South Korean population. DESIGN: Cross-Sectional Study METHODS: Data were included from right eyes of 13,424 participants who were 40 years and older with gradable fundus photographs of the Fourth and the Fifth Korea National Health and Nutrition Examination Survey...
September 14, 2016: American Journal of Ophthalmology
Ike S Okosun, Sara Turbow, Kris McJenkin, Y Monique Davis-Smith, J Paul Seale
OBJECTIVES: Although clinicians do not routinely screen for diabetic retinopathy in non-diabetic patients, previous studies have shown that diabetic retinopathy can occur in patients with prediabetes. However, due to the limitations of glycated hemoglobin (HbA1c) in overweight/obese subjects, African-Americans and older adults, little is known about the correlation between HbA1c and diabetic retinopathy in non-diabetic older overweight/obese African-Americans. The aims of this study were to determine the association between HbA1c and diabetic retinopathy, and the optimal diagnostic threshold of HbA1c that predicts diabetic retinopathy in non-diabetic older overweight/obese African-Americans...
October 2016: Diabetes Research and Clinical Practice
Donghyun Jee, Nana Keum, Seungbum Kang, Jorge G Arroyo
PURPOSE: To investigate the association between sleep duration and diabetic retinopathy (DR). METHODS: A population-based cross-sectional study using a nation-wide, systemically stratified, multistage, clustered sampling method included a total of 1670 subjects aged ≥40 years with diabetes who participated in the Korean National Health and Nutrition Examination Survey during 2008-2012. All participants performed standardized interviews, including self-reported sleep duration, and comprehensive ophthalmic examinations...
July 30, 2016: Acta Ophthalmologica
Tetsuro Tsujimoto, Kenjiro Imai, Sayaka Kanda, Masafumi Kakei, Hiroshi Kajio, Takehiro Sugiyama
BACKGROUND: It remains unknown whether taste disorders can be a risk factor for micro- and macro-vascular diseases in patients with abnormal glucose tolerance. METHODS: A cross-sectional study in a nationally representative samples of 848 and 849 US adults (aged ≥40years) with diabetes or prediabetes who had sweet and salt taste disorders, respectively, from the National Health and Nutrition Examination Survey 2011-2012. RESULTS: Among the study population, 5...
October 15, 2016: International Journal of Cardiology
Tai Kyong Kim, Jae Yon Won, Jeong Ah Shin, Yong-Moon Park, Hyeon Woo Yim, Young-Hoon Park
AIMS: To explore gender differences and associations between metabolic syndrome (MetS) and its components, and diabetic retinopathy (DR) in Korean adults aged 40 years and older with diabetes. METHODS: We analyzed data from the Korean National Health and Nutrition Examination Surveys (2008-2012). In total, 2,576 type 2 diabetic participants, aged 40 and older, were evaluated. Seven standard retinal fundus photographs were obtained after pupil dilation in both eyes...
2016: PloS One
Khaled K Abu-Amero, Altaf A Kondkar, Kakarla V Chalam
Resveratrol, a naturally occurring plant polyphenol found in grapes, is the principal biologically active component in red wine. Clinical studies have shown that resveratrol due to its potent anti-oxidant and anti-inflammatory properties are cardio-protective, chemotherapeutic, neuroprotective, and display anti-aging effects. Oxidative stress and inflammation play a critical role in the initiation and progression of age-related ocular diseases (glaucoma, cataract, diabetic retinopathy and macular degeneration) that lead to progressive loss of vision and blindness...
2016: Nutrients
Ye Elaine Wang, Caitlin Kakigi, Diego Barbosa, Travis Porco, Rebecca Chen, Sophia Wang, Yingjie Li, Kuldev Singh, Louis R Pasquale, Shan C Lin
PURPOSE: To investigate the association between oral contraceptive (OC) use and glaucoma prevalence in the United States. DESIGN: Cross-sectional study. PARTICIPANTS: A total of 3406 female participants, aged 40 years or older, from the 2005 to 2008 National Health and Nutrition Examination Survey, who reported a presence or absence of glaucoma or ocular hypertension completed both the vision and the reproductive health questionnaires and underwent eye examinations...
April 2016: Ophthalmology
Donghyun Jee, Seungbum Kang, Changzheng Yuan, Eunyoung Cho, Jorge G Arroyo
PURPOSE: To investigate associations between serum 25-hydroxyvitamin D levels and dry eye syndrome (DES), and to evaluate the differential effect of vitamin D on ocular diseases including age-related macular disease (AMD), diabetic retinopathy (DR), cataract, and DES. METHODS: A total of 16,396 participants aged >19 years were randomly selected from the Korean National Health and Nutrition Examination Survey. All participants participated in standardized interviews, blood 25-hydroxyvitamin D level evaluations, and comprehensive ophthalmic examinations...
2016: PloS One
Y Lim, S Chun, J H Lee, K H Baek, W K Lee, H-W Yim, M-I Kang
UNLABELLED: Because diabetic retinopathy increases fracture risk, we studied the association between bone mineral density (BMD) and diabetic retinopathy in a nationally representative sample. A significant association between the presence of diabetic retinopathy and low BMD was observed. Therefore, diabetic retinopathy might be considered as a marker of low BMD. INTRODUCTION: Several diabetic complications, including nephropathy, retinopathy, and peripheral neuropathy, are associated with a higher fracture risk in diabetic subjects...
July 2016: Osteoporosis International
I Ksira, K Ounaissa, W Grira, H Sfar, A Ben Brahim, A Abid
OBJECTIFS: Les objectifs de notre étude étaient de déterminer la fréquence de l'HTA chez les patients diabétiques de type 2, de décrire le profil clinique de ces patients, de préciser les modalités thérapeutiques et de déterminer le rôle de l'HTA dans l'aggravation des complications chroniques du diabète. L'HTA est fréquemment associée au diabète, majorant ainsi le risque cardiovasculaire des patients diabétiques. MéTHODES: Étude rétrospective descriptive incluant 100 patients diabétiques de type 2 suivis à l'hôpital de jour de l'Institut National de Nutrition durant le premier trimestre de l'année 2015...
December 2015: Annales de Cardiologie et D'angéiologie
Alison L Reynolds, Yolanda Alvarez, Temitope Sasore, Nora Waghorne, Clare T Butler, Claire Kilty, Andrew J Smith, Carmel McVicar, Vickie H Y Wong, Orla Galvin, Stephanie Merrigan, Janina Osman, Gleb Grebnev, Anita Sjölander, Alan W Stitt, Breandán N Kennedy
Retinal angiogenesis is tightly regulated to meet oxygenation and nutritional requirements. In diseases such as proliferative diabetic retinopathy and neovascular age-related macular degeneration, uncontrolled angiogenesis can lead to blindness. Our goal is to better understand the molecular processes controlling retinal angiogenesis and discover novel drugs that inhibit retinal neovascularization. Phenotype-based chemical screens were performed using the ChemBridge Diverset(TM)library and inhibition of hyaloid vessel angiogenesis in Tg(fli1:EGFP) zebrafish...
April 1, 2016: Journal of Biological Chemistry
Manju Mamtani, Joanne E Curran, John Blangero, Hemant Kulkarni
Background. An epidemiological association between exposure to phthalates and type 2 diabetes (T2D) is known. However, the potential role of environmental phthalates in the complications of T2D is unknown. Methods. Using data from the National Health and Nutrition Examination Survey (NHANES) 2001-2010, we studied the association of 12 urinary phthalate metabolites with self-reported eye affliction/retinopathy in 1,004 participants with diabetes. Data from retinal imaging was used to validate this outcome. Independence of the phthalates→T2D association was studied by adjusting for age, sex, race, marital status, educational attainment, poverty income ratio, physical activity, glycated hemoglobin levels, total serum cholesterol, serum high-density lipoprotein cholesterol, serum triglycerides, blood pressure, duration of diabetes, total calorie intake, and obesity...
2016: Journal of Diabetes Research
Jan M Keppel Hesselink, Ciro Costagliola, Josiane Fakhry, David J Kopsky
Retinopathy is a threat to the eyesight, and glaucoma and diabetes are the main causes for the damage of retinal cells. Recent insights pointed out a common pathogenetic pathway for both disorders, based on chronic inflammation. Palmitoylethanolamide (PEA) is an endogenous cell protective lipid. Since its discovery in 1957 as a biologically active component in foods and in many living organisms, around 500 scientific papers have been published on PEA's anti-inflammatory and neuron-protective properties. PEA has been evaluated for glaucoma, diabetic retinopathy, and uveitis, pathological states based on chronic inflammation, respiratory disorders, and various pain syndromes in a number of clinical trials since the 70s of 20th century...
2015: Journal of Ophthalmology
Kyung Chul Yoon, Won Choi, Hyo Seok Lee, Sang-Duck Kim, Seung-Hyun Kim, Chan Yun Kim, Ki Ho Park, Young Jeung Park, Seung-Hee Baek, Su Jeong Song, Jae Pil Shin, Suk-Woo Yang, Seung-Young Yu, Jong Soo Lee, Key Hwan Lim, Kyung Won Oh, Se Woong Kang
The Korea National Health and Nutrition Examination Survey (KNHANES) is a national program designed to assess the health and nutritional status of the noninstitutionalized population of South Korea. The KNHANES was initiated in 1998 and has been conducted annually since 2007. Starting in the latter half of 2008, ophthalmologic examinations were included in the survey in order to investigate the prevalence and risk factors of common eye diseases such as visual impairment, refractive errors, strabismus, blepharoptosis, cataract, pterygium, diabetic retinopathy, age-related macular degeneration, glaucoma, dry eye disease, and color vision deficiency...
December 2015: Korean Journal of Ophthalmology: KJO
Edward C Kondrot
CONTEXT: Eye conditions that are considered progressive and degenerative and for which the causation is generally poorly understood or not understood within conventional medicine can respond to natural therapeutic interventions that result in arrest and/or improvement of morbidity, with enhanced functional results. Because many of the treated conditions are age related, a delay of disease progression for 5 or even 10 y can mean an additional decade of independence for seniors. The 11 included ocular conditions are ordinarily considered incurable by any method except surgery and, even with surgery, the outcomes can be variable and/or transient...
November 2015: Alternative Therapies in Health and Medicine
Andrés Díaz-López, Nancy Babio, Miguel A Martínez-González, Dolores Corella, Antonio J Amor, Montse Fitó, Ramon Estruch, Fernando Arós, Enrique Gómez-Gracia, Miquel Fiol, José Lapetra, Lluís Serra-Majem, Josep Basora, F Javier Basterra-Gortari, Vicente Zanon-Moreno, Miguel Ángel Muñoz, Jordi Salas-Salvadó
OBJECTIVE: To date no clinical trials have evaluated the role of dietary patterns on the incidence of microvascular diabetes complications. We hypothesized that a nutritional intervention based on the Mediterranean diet (MedDiet) would have greater protective effect on diabetic retinopathy and nephropathy than a low-fat control diet. RESEARCH DESIGN AND METHODS: This was a post hoc analysis of a cohort of patients with type 2 diabetes participating in the PREvención con DIeta MEDiterránea (PREDIMED) study, a multicenter randomized nutritional intervention trial conducted in a population at high cardiovascular risk...
November 2015: Diabetes Care
Floriane Limoge, Laurence Faivre, Thomas Gautier, Jean-Michel Petit, Elodie Gautier, David Masson, Gaëtan Jego, Salima El Chehadeh-Djebbar, Nathalie Marle, Virginie Carmignac, Valérie Deckert, Marie-Claude Brindisi, Patrick Edery, Jamal Ghoumid, Edward Blair, Laurent Lagrost, Christel Thauvin-Robinet, Laurence Duplomb
Cohen Syndrome (CS) is a rare autosomal recessive disorder, with defective glycosylation secondary to mutations in the VPS13B gene, which encodes a protein of the Golgi apparatus. Besides congenital neutropenia, retinopathy and intellectual deficiency, CS patients are faced with truncal obesity. Metabolism investigations showed abnormal glucose tolerance tests and low HDL values in some patients, and these could be risk factors for the development of diabetes mellitus and/or cardiovascular complications. To understand the mechanisms involved in CS fat storage, we used two models of adipogenesis differentiation: (i) SGBS pre-adipocytes with VPS13B invalidation thanks to siRNA delivery and (ii) CS primary fibroblasts...
December 1, 2015: Human Molecular Genetics
Ping Wang, Fei Xia
Neurotrophic factor decreased in the early stage of diabetic retinal nerve cells. Neurons damage brain derived neurotrophic factor (BDNF) and receptor TrkB expression reduced. Erythropoietin (EPO) plays an important role in protecting early diabetic retinopathy. The rats were euthanized at 24 h after EPO vitreous injection and the retina was separated. HE staining was applied to observe the pathological tissue morphology. Immunohistochemistry, immunofluorescence, and Western blot were used to detect BDNF, TrkB, extracellular signal-regulated kinase (ERK), and glial fibrillary acidic portein (GFAP) expression...
2015: International Journal of Clinical and Experimental Pathology
Mary Qiu, Carol L Shields
PURPOSE: To describe the prevalence of choroidal nevus in the US population and identify possible associated factors. DESIGN: Cross-sectional study. PARTICIPANTS: A total of 5575 participants aged ≥40 years from the 2005-2008 National Health and Nutrition Examination Survey (NHANES) who underwent retinal imaging examination. METHODS: Predictor variables included a spectrum of demographic, ophthalmic, dermatologic, systemic, socioeconomic, or occupational factor variables available in NHANES...
October 2015: Ophthalmology
Zahra Yekta, Dawei Xie, Hillary R Bogner, David R Weber, Xinzhi Zhang, Michael Harhay, Peter P Reese
OBJECTIVE: To determine if the use of antidepressants was associated with lower odds of diabetic retinopathy and if so, to determine if this association was mediated by decreased inflammation as measured by C-reactive protein (CRP). DESIGN: This was a cross sectional study of 1,041 participants with type 2 diabetes 40-85years old from the 2005-2008 National Health and Nutrition Examination Survey (NHANES). Multiple logistic regression was used to examine the association between the outcome of diabetic retinopathy and the primary exposure of antidepressant medication usage...
November 2015: Journal of Diabetes and its Complications
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