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Withania somnifera

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https://www.readbyqxmd.com/read/28599249/important-medicinal-herbs-in-parkinson-s-disease-pharmacotherapy
#1
REVIEW
Saurabh Srivastav, Mahino Fatima, Amal Chandra Mondal
Parkinson's disease (PD) is the most common progressive neurodegenerative movement disorder affecting more than 10 million people worldwide. The characteristic hallmark of PD involves progressive loss of dopaminergic (DA-ergic) neuron in Substantia Nigra pars compacta (SNpc) region of the brain, however, aetiology of the disease still remains unclear. Mitochondrial dysfunction and oxidative insult are considered to be the key culprit. The current therapy available for PD primarily relies on Levodopa that offers the potential of slowing down disease progression to some extent but includes lot of side effects...
June 6, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28593171/withania-somnifera-targets-interleukin-8-and-cyclooxygenase-2-in-human-prostate-cancer-progression
#2
Anand Setty Balakrishnan, Abel Arul Nathan, Mukesh Kumar, Sudhakar Ramamoorthy, Sathish Kumar Ramia Mothilal
BACKGROUND: Prostate cancer (PC) is a common noncutaneous malignancy in men. The incidence of PC is increasing at an alarming rate across the globe. Progression of PC is associated with elevated levels of interleukin-8 (IL-8) and cyclooxygenase-2 (COX-2) in malignant cells. Overexpression of these players is accompanied by chronic inflammation, increased angiogenesis, proliferation, migration, and inhibition of apoptosis. Moreover, their elevated circulating levels promote the disease progression from androgen-dependent to androgen-independent state...
June 2017: Prostate International
https://www.readbyqxmd.com/read/28575108/changes-in-the-leaf-proteome-profile-of-withania-somnifera-l-dunal-in-response-to-alternaria-alternata-infection
#3
Varinder Singh, Baldev Singh, Robin Joshi, Puneet Jaju, Pratap Kumar Pati
Withania somnifera is a high value medicinal plant which is used against large number of ailments. The medicinal properties of the plant attributes to a wide array of important secondary metabolites. The plant is predominantly infected with leaf spot pathogen Alternaria alternata, which leads to substantial biodeterioration of pharmaceutically important metabolites. To develop an effective strategy to combat this disease, proteomics based approach could be useful. Hence, in the present study, three different protein extraction methods tris-buffer based, phenol based and trichloroacetic acid-acetone (TCA-acetone) based method were comparatively evaluated for two-dimensional electrophoresis (2-DE) analysis of W...
2017: PloS One
https://www.readbyqxmd.com/read/28574986/an-ethnobotanical-survey-of-indigenous-medicinal-plants-in-hafizabad-district-punjab-pakistan
#4
Muhammad Umair, Muhammad Altaf, Arshad Mehmood Abbasi
Present paper offers considerable information on traditional uses of medicinal plants by the inhabitants of Hafizabad district, Punjab-Pakistan. This is the first quantitative ethnobotanical study from the area comprising popularity level of medicinal plant species intendedby using relative popularity level (RPL) and rank order priority (ROP) indices.Ethnobotanical data were collected by interviewing 166 local informants and 35 traditional health practioners (THPs) from different localities of Hafizabad district...
2017: PloS One
https://www.readbyqxmd.com/read/28553635/alcoholic-fractions-f5-and-f6-from-withania-somnifera-leaves-show-a-potent-antileishmanial-and-immunomodulatory-activities-to-control-experimental-visceral-leishmaniasis
#5
Sambamurthy Chandrasekaran, Jalaja Veronica, Shyam Sundar, Radheshyam Maurya
Visceral leishmaniasis (VL) causes fatal life-threatening disease, if left untreated. The current drugs have various limitations; hence, natural products from medicinal plants are being focused in search of new drugs to treat leishmaniasis. The aim of the present study was to evaluate the antileishmanial and immunomodulatory activities of F5 and F6 alcoholic fractions from Withania somnifera leaves and purified withaferin-A in Leishmania donovani-infected peritoneal macrophages and BALB/c mice. We observed that F5 (15 µg/mL), F6 (10 µg/mL), and withaferin-A (1...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28553006/determination-of-mycotoxins-alkaloids-phytochemicals-antioxidants-and-cytotoxicity-in-asiatic-ginseng-ashwagandha-dong-quai-panax-ginseng
#6
Anna Filipiak-Szok, M Kurzawa, E Szłyk, M Twarużek, A Błajet-Kosicka, J Grajewski
Mycotoxins and selected hazardous alkaloids in the medicinal plants (Panax ginseng, Angelica sinensis, and Withania somnifera) and dietary supplements were determined. Purine alkaloids were found in majority of samples; however, isoquinoline alkaloids were less abundant than indole. The predominant alkaloids appear to be caffeine (purine group), harman (indole group) and berberine (isoquinoline). Examined medicinal plants and dietary supplements were contaminated by mycotoxins (especially ochratoxin A 1.72-5...
2017: Chemické Zvesti
https://www.readbyqxmd.com/read/28526626/longevity-and-healthy-ageing-genes-foxo3a-and-sirt3-serum-protein-marker-and-new-road-map-to-burst-oxidative-stress-by-withania-somnifera
#7
Rashmita Pradhan, Rahul Kumar, Shashank Shekhar, Nitish Rai, Akash Ambashtha, Joyita Banerjee, Mona Pathak, S N Dwivedi, Sharmistha Dey, Aparajit B Dey
BACKGROUND: Ageing process is characterized by a decline in function; different age related diseases and excessive age associated mortality. There has always been a quest for easily accessible biomarkers to monitor and identify the development of age-associated stress for providing new anti-ageing strategies. Forkhead box protein O3A (FOXO3A) and Sirtuin3 (SIRT3) are such potential markers which plays important role in a wide variety of cellular mechanisms and has been proposed to be an ideal candidate to study longevity and are potential candidate for healthy ageing by oxidative burst...
September 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28510600/complete-comparison-display-ccd-evaluation-of-ethanol-extracts-of-centella-asiatica-and-withania-somnifera-shows-that-they-can-non-synergistically-ameliorate-biochemical-and-behavioural-damages-in-mptp-induced-parkinson-s-model-of-mice
#8
Maheep Bhatnagar, Ishan Goel, Tathagato Roy, Sunil Dutt Shukla, Sukant Khurana
Parkinson's disease remains as one of the most common debilitating neurodegenerative disorders. With the hopes of finding agents that can cure or reduce the pace of progression of the disease, we studied two traditional medicinal plants: Centella asiatica and Withania somnifera that have been explored in some recent studies. In agreement with the previous work on ethanol extracts of these two plants in mice model, we saw an improvement in oxidative stress profile as well as behavioral performance in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced Parkinson-like symptoms in Balb/c mice...
2017: PloS One
https://www.readbyqxmd.com/read/28488219/inhibition-of-gelatinases-mmp-2-and-mmp-9-by-withania-somnifera-phytochemicals-confers-neuroprotection-in-stroke-an-in-silico-analysis
#9
Gaurav Kumar, Ranjana Patnaik
A stroke or cerebrovascular accident is a serious, life-threatening medical condition that occurs when the blood supply to part of the brain is severely reduced or cut off, depriving brain tissue of oxygen and nutrients. Studies suggested that level of gelatinases (MMP-2 and MMP-9) usually increases in the brain after stroke. The elevated activity of gelatinases plays the deleterious role in ischemic stroke, hemorrhagic stroke and perinatal hypoxic-ischemic brain injury. Therefore, matrix metalloproteinase (MMP)-2 and MMP-9 inhibition have therapeutic importance in stroke condition...
May 9, 2017: Interdisciplinary Sciences, Computational Life Sciences
https://www.readbyqxmd.com/read/28472734/comparative-in-silico-analyses-of-cannabis-sativa-prunella-vulgaris-and-withania-somnifera-compounds-elucidating-the-medicinal-properties-against-rheumatoid-arthritis
#10
Mehreen Zaka, Sheikh Arslan Sehgal, Shagufta Shafique, Bilal Haider Abbasi
From last decade, there has been progressive improvement in computational drug designing. Several diseases are being cured from different plant extracts and products. Rheumatoid arthritis (RA) is the most shared disease among auto-inflammatory diseases. Tumor necrosis factor (TNF)-α is associated with RA pathway and has adverse effects. Extensive literature review showed that plant species under study (Cannabis sativa, Prunella vulgaris and Withania somnifera) possess anti-inflammatory, anti-arthritic and anti-rheumatic properties...
April 19, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28471731/efficacy-and-safety-of-ashwagandha-withania-somnifera-l-dunal-root-extract-in-improving-memory-and-cognitive-functions
#11
Dnyanraj Choudhary, Sauvik Bhattacharyya, Sekhar Bose
OBJECTIVES: Cognitive decline is often associated with the aging process. Ashwagandha (Withania somnifera (L.) Dunal) has long been used in the traditional Ayurvedic system of medicine to enhance memory and improve cognition. AIM: This pilot study was designed to evaluate the efficacy and safety of ashwagandha (Withania somnifera (L.) Dunal) in improving memory and cognitive functioning in adults with mild cognitive impairment (MCI). METHODS: A prospective, randomized, double-blind, placebo-controlled study was conducted in 50 adults...
November 2, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28466063/immunomodulatory-and-prophylactic-efficacy-of-herbal-extracts-against-experimentally-induced-chicken-infectious-anaemia-in-chicks-assessing-the-viral-load-and-cell-mediated-immunity
#12
Shyma K Latheef, K Dhama, Hari Abdul Samad, Mohd Yaqoob Wani, M Asok Kumar, M Palanivelu, Yashpal Singh Malik, S D Singh, Rajendra Singh
Chicken infectious anaemia virus (CIAV) is an economically important and a highly immunosuppressive virus affecting poultry industry worldwide. In this study we assessed the immunomodulatory effects of four herbal preparations namely Withania somnifera, Tinospora cordifolia, Azadirachta indica and E Care Se Herbal in resisting the viral multiplication and immunosuppression inflicted by CIAV in chicks. Day-old chicks (n = 90) were randomly and equally divided into six groups (Groups A-F). Groups A-D were administered with purified extracts of W...
March 2017: Virusdisease
https://www.readbyqxmd.com/read/28462131/effect-of-combination-of-withania-somnifera-dunal-and-tribulus-terrestris-linn-on-letrozole-induced-polycystic-ovarian-syndrome-in-rats
#13
Amrin Saiyed, Nasreen Jahan, Shaikh Ajij Ahmed Makbul, Mushir Ansari, Humaira Bano, Syeda Hajera Habib
BACKGROUND: To investigate the effect of the combination of hydroalcoholic extract of Withania somnifera (WS) and Tribulus terrestris (TT) on letrozole induced polycystic ovarian syndrome (PCOS) in rat. METHODS: Twenty four female Wistar rats of regular estrus cycle were divided into four groups of six animals each. The negative control group received 1 mL of 0.5% carboxy methyl cellulose. The animals of the other groups were treated with letrozole (1 mg/kg) for 21 days for induction of PCOS...
December 2016: Integrative medicine research
https://www.readbyqxmd.com/read/28447311/attenuation-of-glutamate-induced-excitotoxicity-by-withanolide-a-in-neuron-like-cells-role-for-pi3k-akt-mapk-signaling-pathway
#14
Nawab John Dar, Naresh Kumar Satti, Prabhu Dutt, Abid Hamid, Muzamil Ahmad
Glutamate-induced excitotoxicity is one of the major underlying mechanisms for neurodegenerative diseases. Efforts are being made to treat such conditions with an array of natural compounds that can modulate the release of glutamate or the underlying mechanisms associated with it. Withania somnifera extract has potent pharmacologic activity similar to that of Korean Ginseng tea and is used to treat several neuronal disorders. However, to date, little efforts have been made to evaluate individual constituents of this plant for neurodegenerative disorders...
April 26, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28425984/withaferin-a-kills-cancer-cells-with-and-without-telomerase-chemical-computational-and-experimental-evidences
#15
Yue Yu, Shashank P Katiyar, Durai Sundar, Zeenia Kaul, Eijiro Miyako, Zhenya Zhang, Sunil C Kaul, Roger R Reddel, Renu Wadhwa
Maintenance of telomere length is the most consistent attribute of cancer cells. Tightly connected to their capacity to overcome replicative mortality, it is achieved either by activation of telomerase or an Alternative mechanism of Lengthening of Telomeres (ALT). Disruption of either of these mechanisms has been shown to induce DNA damage signalling leading to senescence or apoptosis. Telomerase inhibitors are considered as potential anticancer drugs but are ineffective for ALT cancers (~15% of all cancers)...
April 20, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28407087/rp-hplc-separation-of-isomeric-withanolides-method-development-validation-and-application-to-in-situ-rat-permeability-determination
#16
Mohd Yaseen Malik, Isha Taneja, Kanumuri Siva Rama Raju, Jiaur Rahaman Gayen, Sheelendra Pratap Singh, Neelam S Sangwand, Muhammad Wahajuddin
Withanolides are the group of active chemical constituents of Withania somnifera (L.) Dunal. Withaferin A, withanolide A and withanone presents three of the biologically most active constituents of this herb. These steroidal lactones are isomers of each other and thus, pose significant difficulty in their separation. In present study, a simple, specific and reliable RP-HPLC method has been developed and validated for their separation and simultaneous quantification. Separation was carried out on Lichrocart Purospher STAR RP-18e column (250 × 4...
April 12, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28387888/withaferin-a-induces-apoptosis-in-osteosarcoma-u2os-cell-line-via-generation-of-ros-and-disruption-of-mitochondrial-membrane-potential
#17
A-X Li, M Sun, X Li
OBJECTIVE: Withaferin-A (WF-A) is a well-known dietary compound isolated from Withania somnifera. It has marked pharmacological potential and has been shown to exhibit antiproliferative activity against several types of cancerous cells. Currently, the main focus of anti-cancer therapeutic development is to identify apoptosis-inducing drug-like molecules. Osteosarcoma is a rare type of bone cancer affecting humans. The objective of the present study was therefore to evaluate the antitumor potential of WF-A against several osteosarcoma cell lines...
March 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28377654/a-comparative-study-of-ion-diffusion-from-calcium-hydroxide-with-various-herbal-pastes-through-dentin
#18
Priyanka Dausage, Rajesh B Dhirawani, Jayant Marya, Vrinda Dhirawani, Vijayendra Kumar
AIM: The aim of this study was to evaluate the diffusion ability of ions through dentinal tubules of different nonalcoholic calcium hydroxide-containing herbal pastes and compare it with the calcium hydroxide paste prepared with saline. MATERIALS AND METHODS: A total of 36 single-rooted premolar teeth were used in this study. The tooth crowns were removed and the root canals were prepared. Depending on the vehicle to be used for preparing calcium hydroxide pastes, six groups were made: Group I: Ca(OH)2 saline paste (control group), group II: Ca(OH)2 papaya latex paste, group III: Ca(OH)2 coconut water paste, group IV: Ca(OH)2 Ashwagandha (Withania somnifera) paste, group V: Ca(OH)2 Tulsi (Ocimum tenuiflorum) paste, and group VI: Ca(OH)2 garlic (Allium sativum) paste...
January 2017: International Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28365961/withaferin-a-induces-mitochondrial-dependent-apoptosis-in-non-small-cell-lung-cancer-cells-via-generation-of-reactive-oxygen-species
#19
Xi Liu, Lei Chen, Tao Liang, Xiao-Dong Tian, Yang Liu, Tao Zhang
PURPOSE: Withaferin A (WA) is a bioactive lactone, isolated from natural sources, mainly found in Withania somnifera, and was known to be highly effective against a variety of tumor cells both in vitro and in vivo. Accumulating experimental evidence suggests the involvement of reactive oxygen species (ROS) in WA-mediated cytotoxicity against cancer cells. Hence, the purpose of this study was to investigate the effect of WA in non-small cell lung cancer (NSCLC) cells and also the role of ROC in WA-mediated cytotoxicity...
January 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28299798/sterol-glycosyltransferases-required-for-adaptation-of-withania-somnifera-at-high-temperature
#20
Gaurav Singh, Manish Tiwari, Surendra P Singh, Ruchi Singh, Surendra Singh, Pramod A Shirke, Prabodh K Trivedi, Pratibha Misra
Heat is a major environmental stress factor that confines growth, productivity, and metabolism of plants. Plants respond to such unfavorable conditions through changes in their physiological, biochemical and developmental processes. Withania somnifera, an important medicinal plant, grows in hot and dry conditions, however, molecular mechanisms related to such adaptive properties are not known. Here, we elucidated that members of the sterol glycosyltransferases (SGT) gene family play important roles in the survival of W...
March 16, 2017: Physiologia Plantarum
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