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Withania somnifera

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https://www.readbyqxmd.com/read/29770466/comparative-evaluation-of-the-effects-of-withania-somnifera-with-pentoxifylline-on-the-sperm-parameters-in-idiopathic-male-infertility-a-triple-blind-randomised-clinical-trial
#1
R Nasimi Doost Azgomi, H Nazemiyeh, H Sadeghi Bazargani, S M B Fazljou, F Nejatbakhsh, A Moini Jazani, Y Ahmadi AsrBadr, A Zomorrodi
In this triple-blind randomised clinical trial, we compared the effects of Withania somnifera and pentoxifylline on the sperm parameters in idiopathic male infertility. One hundred infertile male patients were randomly allocated into either W. somnifera or pentoxifylline groups. Patients in the herbal group received six capsules containing 5 g/daily of W. somnifera root, and subjects in the pentoxifylline group received six capsules containing 800 mg/daily of pentoxifylline and placebo for 90 days. Sperm parameters were analysed at the beginning and end of the study...
May 16, 2018: Andrologia
https://www.readbyqxmd.com/read/29719462/genetic-variability-associations-and-path-analysis-of-chemical-and-morphological-traits-in-indian-ginseng-withania-somnifera-l-dunal-for-selection-of-higher-yielding-genotypes
#2
Abhilasha Srivastava, Anil K Gupta, Karuna Shanker, Madan M Gupta, Ritu Mishra, Raj K Lal
Background: The study was carried out to assess the genetic variability present in ashwagandha and to examine the nature of associations of various traits to the root yield of the plant. Methods: Fifty-three diverse genetic stocks of ashwagandha ( Withania somnifera ) were evaluated for 14 quantitative characteristics. Analysis of variance, correlation, and path coefficient analysis were performed using the mean data of 2 years. Results: Analysis of variance revealed that the genotypes differed significantly for all characteristics studied...
April 2018: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29671210/indian-ginseng-withania-somnifera-supplementation-ameliorates-oxidative-stress-and-mitochondrial-dysfunctions-in-experimental-model-of-stroke
#3
Abhilasha Sood, Arpit Mehrotra, Devinder K Dhawan, Rajat Sandhir
Stroke is an increasingly prevalent clinical condition and second leading cause of death globally. The present study evaluated the therapeutic potential of Indian Ginseng, also known as Withania somnifera (WS), supplementation on middle cerebral artery occlusion (MCAO) induced mitochondrial dysfunctions in experimental model of ischemic stroke. Stroke was induced in animals by occluding the middle cerebral artery, followed by reperfusion injury. Ischemia reperfusion injury resulted in increased oxidative stress indicated by increased reactive oxygen species and protein carbonyl levels; compromised antioxidant system; in terms of reduced superoxide dismutase and catalase activity, along with reduction in GSH levels and the redox ratio, impaired mitochondrial functions and enhanced expression of apoptosis markers...
April 18, 2018: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29670898/effects-of-withania-somnifera-on-reproductive-system-a-systematic-review-of-the-available-evidence
#4
REVIEW
Ramin Nasimi Doost Azgomi, Afshar Zomorrodi, Hossein Nazemyieh, Seyed Mohammad Bagher Fazljou, Homayoun Sadeghi Bazargani, Fatemeh Nejatbakhsh, Arezoo Moini Jazani, Yadollah Ahmadi AsrBadr
Introduction: Withania somnifera (WS) also known as ashwagandha is a well-known medicinal plant used in traditional medicine in many countries for infertility treatment. The present study was aimed at systemically reviewing therapeutic effects of WS on the reproductive system. Methods: This systematic review study was designed in 2016. Required data were obtained from PubMed, Scopus, Google Scholar, Cochrane Library, Science Direct, Web of Knowledge, Web of Science, and manual search of articles, grey literature, reference checking, and expert contact...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29661206/homology-modelling-molecular-docking-and-molecular-dynamics-simulations-reveal-the-inhibition-of-leishmania-donovani-dihydrofolate-reductase-thymidylate-synthase-enzyme-by-withaferin-a
#5
Bharadwaja Vadloori, A K Sharath, N Prakash Prabhu, Radheshyam Maurya
OBJECTIVE: Present in silico study was carried out to explore the mode of inhibition of Leishmania donovani dihydrofolate reductase-thymidylate synthase (Ld DHFR-TS) enzyme by Withaferin-A, a withanolide isolated from Withania somnifera. Withaferin-A (WA) is known for its profound multifaceted properties, but its antileishmanial activity is not well understood. The parasite's DHFR-TS enzyme is diverse from its mammalian host and could be a potential drug target in parasites. RESULTS: A 3D model of Ld DHFR-TS enzyme was built and verified using Ramachandran plot and SAVES tools...
April 16, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29659590/organic-cultivation-of-ashwagandha-with-improved-biomass-and-high-content-of-active-withanolides-use-of-vermicompost
#6
Amandeep Kaur, Baldev Singh, Puja Ohri, Jia Wang, Renu Wadhwa, Sunil C Kaul, Pratap Kumar Pati, Arvinder Kaur
Withania somnifera (Ashwagandha) has recently been studied extensively for its health-supplementing and therapeutic activities against a variety of ailments. Several independent studies have experimentally demonstrated pharmaceutical potential of its active Withanolides, Withaferin A (Wi-A), Withanone (Wi-N) and Withanolide A (Wil-A). However, to promote its use in herbal industry, an environmentally sustainable cultivation and high yield are warranted. In modern agriculture strategies, there has been indiscriminate use of chemical fertilizers to boost the crop-yield, however the practice largely ignored its adverse effect on the quality of soil and the environment...
2018: PloS One
https://www.readbyqxmd.com/read/29615668/endophytes-of-withania-somnifera-modulate-in-planta-content-and-the-site-of-withanolide-biosynthesis
#7
Shiv S Pandey, Sucheta Singh, Harshita Pandey, Madhumita Srivastava, Tania Ray, Sumit Soni, Alok Pandey, Karuna Shanker, C S Vivek Babu, Suchitra Banerjee, M M Gupta, Alok Kalra
Tissue specific biosynthesis of secondary metabolites is a distinguished feature of medicinal plants. Withania somnifera, source of pharmaceutically important withanolides biosynthesizes withaferin-A in leaves and withanolide-A in roots. To increase the in planta withanolides production, a sustainable approach needs to be explored. Here, we isolated endophytes from different parts of W. somnifera plants and their promising role in in planta withanolide biosynthesis was established in both in-vivo grown as well in in-vitro raised composite W...
April 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29575228/herbal-medicines-in-the-treatment-of-psychiatric-disorders-10-year-updated-review
#8
REVIEW
Jerome Sarris
This paper provides a 10-year update of the 2007 systematic review of herbal medicines studied in a broad range of psychiatric disorders, including depression, anxiety, obsessive-compulsive, seasonal affective, bipolar, psychotic, phobic, somatoform, and attention-deficit hyperactivity disorders. Ovid Medline, PubMed, and the Cochrane Library were searched for herbal medicines with both pharmacological and clinical evidence of psychotropic activity. This updated review now covers clinical trial evidence for 24 herbal medicines in 11 psychiatric disorders...
March 25, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29568180/alleviation-of-heat-stress-by-a-polyherbal-formulation-phytocee%C3%A2-impact-on-zootechnical-parameters-cloacal-temperature-and-stress-markers
#9
Ramasamy Selvam, Subramaniyam Suresh, Marimuthu Saravanakumar, C V Chandrasekaran, D'Souza Prashanth
Background: The range of thermoneutral zone of chickens is narrow, and they become easily susceptible to environmental stress, a common and major concern for poultry causing a production loss. Objective: The present study was designed to comparatively evaluate anti-stress activity of Phytocee™ and Vitamin C in chickens reared under heat stress. Materials and Methods: A total of 600-day-old chicks of Cobb 400 were randomly assigned to 4 groups with 6 replicates comprising 25 birds each ( n = 150)...
January 2018: Pharmacognosy Research
https://www.readbyqxmd.com/read/29492788/characterization-of-an-insecticidal-protein-from-withania-somnifera-against-lepidopteran-and-hemipteran-pest
#10
Blessan Santhosh George, S Silambarasan, K Senthil, John Prasanth Jacob, Modhumita Ghosh Dasgupta
Lectins are carbohydrate-binding proteins with wide array of functions including plant defense against pathogens and insect pests. In the present study, a putative mannose-binding lectin (WsMBP1) of 1124 bp was isolated from leaves of Withania somnifera. The gene was expressed in E. coli, and the recombinant WsMBP1 with a predicted molecular weight of 31 kDa was tested for its insecticidal properties against Hyblaea puera (Lepidoptera: Hyblaeidae) and Probergrothius sanguinolens (Hemiptera: Pyrrhocoridae)...
April 2018: Molecular Biotechnology
https://www.readbyqxmd.com/read/29491636/viwithan-a-standardized-withania-somnifera-root-extract-induces-apoptosis-in-murine-melanoma-cells
#11
H V Sudeep, K Gouthamchandra, B J Venkatesh, K Shyam Prasad
Background: Withania somnifera is an Indian medicinal herb known for the multipotential ability to cure various therapeutic ailments as described in the ayurvedic system of medicine. Objective: In the present study, we have evaluated the antiproliferative activity of a standardized W. somnifera root extract (Viwithan) against different human and murine cancer cell lines. Materials and Methods: The cytotoxicity of Viwithan was determined using thiazolyl blue tetrazolium blue assay and crystal violet staining...
January 2018: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29484895/in-vivo-evaluation-of-withania-somnifera-based-indian-traditional-formulation-amukkara-choornam-against-chikungunya-virus-induced-morbidity-and-arthralgia
#12
Jaspreet Jain, Vimal Narayanan, Shivam Chaturvedi, Somnath Pai, Sujatha Sunil
Chikungunya viral fever results in extreme morbidity and arthralgia in affected individuals. Currently, modern medicines providing symptomatic relief for the acute febrile phase and the chronic arthritic phase are only options available. Traditional Indian medical system, however, uses specific formulations for treatment of this infection; one such polyherbal formulation used to treat the postpyretic phase of chikungunya is amukkara choornam. The current study was undertaken to study the efficacy of amukkara choornam in the treatment of chikungunya in C57BL/6J mice...
January 2018: Journal of evidence-based integrative medicine
https://www.readbyqxmd.com/read/29476318/comparative-study-of-withanolide-biosynthesis-related-mirnas-in-root-and-leaf-tissues-of-withania-somnifera
#13
Swati Srivastava, Sanchita, Ruchi Singh, Gaurava Srivastava, Ashok Sharma
Withania somnifera, popularly known as Indian ginseng, is one of the most important medicinal plants. The plant is well studied in terms of its pharmaceutical activities and genes involved in biosynthetic pathways. However, not much is known about the regulatory mechanism of genes responsible for the production of secondary metabolites. The idea was to identify miRNA transcriptome responsible for the regulation of withanolide biosynthesis, specifically of root and leaf tissues individually. The transcriptome data of in vitro culture of root and leaf tissues of the plant was considered for miRNA identification...
February 24, 2018: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/29476116/hmg-coa-reductase-from-camphor-tulsi-ocimum-kilimandscharicum-regulated-mva-dependent-biosynthesis-of-diverse-terpenoids-in-homologous-and-heterologous-plant-systems
#14
Shilpi Bansal, Lokesh Kumar Narnoliya, Bhawana Mishra, Muktesh Chandra, Ritesh Kumar Yadav, Neelam Singh Sangwan
Ocimum kilimandscharicum is unique in possessing terpenoids whereas other Ocimum species are renowned for phenylpropanoids as major constituents of essential oil. The key enzyme of MVA/terpenoid metabolic pathway viz 3-hydroxy-3-methylglutaryl Co-A reductase (OkHMGR) of 1.7-Kb ORF encoding ~60-kDa protein was cloned from O. kilimandscharicum and its kinetic characteristics revealed the availability of HMG-CoA as a control point of MVA-pathway. Transcript profiling of the OkHMGR elucidated tissue-specific functions of the gene in flower and leaf tissues in accumulation of terpenoidal essential oil...
February 23, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29453917/comparative-chemical-investigation-and-evaluation-of-antioxidant-and-tyrosinase-inhibitory-effects-of-withania-somnifera-l-dunal-and-solanum-nigrum-l-berries
#15
Abdul Hameed, Naveed Akhtar
In the present study, berries of two different species of Solanaceae family, Withania somnifera (WS) and Solanum nigrum (SN), were extracted in methanol and then fractionated with solvents, ranging from non-polar to polar, for their phytochemical profiling and investigation of antioxidant and tyrosinase enzyme inhibition capacity. The methanolic extract and n-hexane, ethyl acetate (WSEA, SNEA) and aqueous fractions were chemically analyzed and evaluated for biological activity. Total flavonoids and total phenolics were quantified in WSEA (96...
March 1, 2018: Acta Pharmaceutica
https://www.readbyqxmd.com/read/29453255/endophyte-mediated-modulation-of-defense-related-genes-and-systemic-resistance-in-withania-somnifera-l-dunal-under-alternaria-alternata-stress
#16
Aradhana Mishra, Satyendra Pratap Singh, Sahil Mahfooz, Surendra Pratap Singh, Arpita Bhattacharya, Nishtha Mishra, C S Nautiyal
Endophytes have been explored and found to perform an important role in plant health. However, their effects on the host physiological function and disease management remain elusive. The present study aimed to assess the potential effects of endophytes, singly as well as in combination, in Withania somnifera (L.) Dunal, on various physiological parameters and systemic defense mechanisms against Alternaria alternata Seeds primed with the endophytic bacteria Bacillus amyloliquefaciens and Pseudomonas fluorescens individually and in combination demonstrated an enhanced vigor index and germination rate...
April 15, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29448055/proteomic-characterization-of-withaferin-a-targeted-protein-networks-for-the-treatment-of-monoclonal-myeloma-gammopathies
#17
Martin Dom, Fritz Offner, Wim Vanden Berghe, Xaveer Van Ostade
Withaferin A (WA), a natural steroid lactone from the plant Withania somnifera, is often studied because of its antitumor properties. Although many in vitro and in vivo studies have been performed, the identification of Withaferin A protein targets and its mechanism of antitumor action remain incomplete. We used quantitative chemoproteomics and differential protein expression analysis to characterize the WA antitumor effects on a multiple myeloma cell model. Identified relevant targets were further validated by Ingenuity Pathway Analysis and Western blot and indicate that WA targets protein networks that are specific for monoclonal gammopathy of undetermined significance (MGUS) and other closely related disorders, such as multiple myeloma (MM) and Waldenström macroglobulinemia (WM)...
May 15, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29445343/medicinal-plants-from-near-east-for-cancer-therapy
#18
REVIEW
Mohammad S Abu-Darwish, Thomas Efferth
Background: Cancer is one of the major problems affecting public health worldwide. As other cultures, the populations of the Near East rely on medicinal herbs and their preparations to fight cancer. Methods: We compiled data derived from historical ethnopharmacological information as well as in vitro and in vivo results and clinical findings extracted from different literature databases including (PubMed, Scopus, Web of Science, and Google Scholar) during the past two decades. Results: In this survey, we analyzed the huge amount of data available on anticancer ethnopharmacological sources used in the Near East...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29430090/evaluation-of-antibacterial-efficacy-of-biosynthesized-silver-nanoparticles-derived-from-fungi-against-endo-perio-pathogens-porphyromonas-gingivalis-bacillus-pumilus-and-enterococcus-faecalis
#19
Kiran Rahul Halkai, Jayashree A Mudda, Vasundhara Shivanna, Vandana Rathod, Rahul S Halkai
Background: Even after rapid progress in contemporary dental practice, we encounter the failures due to endodontic, periodontal, or combined lesions. Complex anatomy of tooth and resistant microbes demands the development of new treatment strategies. Aim: The aim of this study is to biosynthesize silver nanoparticles (AgNPs) using fungi and determine the antibacterial efficacy against Porphyromonas gingivalis , Bacillus pumilus , and Enterococcus faecalis . Materials and Methods: Fungi isolated from healthy leaves of Withania somnifera were used to biosynthesize AgNPs...
November 2017: Journal of Conservative Dentistry: JCD
https://www.readbyqxmd.com/read/29427754/withanolide-a-extends-the-lifespan-in-human-egfr-driven-cancerous-caenorhabditis-elegans
#20
Bashir Akhlaq Akhoon, Laxmi Rathor, Rakesh Pandey
The conserved EGFR pathway is linked with multiple cancers in humans including breast, ovarian, and lung carcinoma. Withanolide A, one of the major withanolidal active compounds isolated from the Withania somnifera, extends lifespan and ameliorates stress resistance in wild-type C. elegans by targeting the Insulin/IGF-1 signaling pathway. Up-regulation of IGF1 can transactivate EGFR which inturn reduces longevity and promotes tumor development in an organism. We examined the effects of Withanolide A on the lifespan of a human EGFR-driven C...
April 2018: Experimental Gerontology
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