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Multinucleated giant cells

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https://www.readbyqxmd.com/read/28089322/a-central-giant-cell-granuloma-in-posterior-part-of-maxilla-a-case-report
#1
Priyanka Garg, Jinendra Jain, Nayana De, Kushal Chatterjee
INTRODUCTION: Central Giant Cell Granuloma (CGCG) is an intraosseous lesion consisting of cellular fibrous tissue that contains multiple foci of hemorrhage, aggregations of multinucleated giant cells and occasionally trabeculae of woven bone1. PRESENTATION OF CASE: we are presenting a case of Central Giant Cell Granuloma on Maxilla. Extra oral examination revealed a diffuse swelling on the left side of face causing slight obliteration of nasio - nasolabial labial fold resulting in facial asymmetry & Intraoral examination shows a purple expansile mass in the region of upper left 26, 27 and 28 edentulous areas...
November 17, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28067799/excavatolide-b-attenuates-rheumatoid-arthritis-through-the-inhibition-of-osteoclastogenesis
#2
Yen-You Lin, Yen-Hsuan Jean, Hsin-Pai Lee, Sung-Chun Lin, Chieh-Yu Pan, Wu-Fu Chen, Shu-Fen Wu, Jui-Hsin Su, Kuan-Hao Tsui, Jyh-Horng Sheu, Ping-Jyun Sung, Zhi-Hong Wen
Osteoclasts are multinucleated giant cells of macrophage/monocyte lineage, and cell differentiation with the upregulation of osteoclast-related proteins is believed to play a major role in the destruction of the joints in the course of rheumatoid arthritis (RA). Pro-inflammatory cytokines, such as interleukin-17A (IL-17A) and macrophage colony-stimulating factor (M-CSF), can be overexpressed in RA and lead to osteoclastogenesis. In a previous study, we found that cultured-type soft coral-derived excavatolide B (Exc-B) exhibited anti-inflammatory properties...
January 6, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28051991/cutaneous-coccidiomycosis-masquerading-as-an-epidermoid-cyst-case-report-and-review-of-the-literature
#3
Daniel H Russell, Ed Ager, Wendi Wohltman
OBJECTIVES: To present a challenging case of inoculatory fungal mycosis mimicking an epidermoid cyst, which may have been easily overlooked by the pathologist. METHODS: We present a case report of a 29-year-old male with a nodule on the right lower back, which was surgically excised and submitted to pathology as a ruptured epidermoid cyst. RESULTS: Histopathologic sections revealed detached soft tissue fragments containing polymorphic granulomas with abscess and suspicious-appearing spherical structures ranging in size from 50 to 200 μm...
January 2017: Military Medicine
https://www.readbyqxmd.com/read/28033265/an-atypical-sarcoidosis-involvement-in-fdg-pet-ct-a-case-report
#4
Philippe Robin, Paolo Benigni, Benoit Feger, Pierre-Yves Salaun, Ronan Abgral
RATIONALE: Sarcoidosis is an idiopathic systemic inflammatory granulomatous disorder comprised of epithelioid and multinucleated giant cells with little necrosis which involve various organs. Laryngeal involvement is extremely rare, with a prevalence of about 0.5 to 1%. DIAGNOSES: Here we present a case of laryngeal involvement of sarcoidosis demonstrated on F-Fluorodesoxyglucose Positron-Emission Tomography/Computed Tomography (FDG PET/CT). PATIENT CONCERNS: A 63 year-old man suffering from dysphonia was referred to our department for characterization of laryngeal lesion suspicious for cancer with non-informative biopsy, the sample was not sufficient for diagnosis...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28029189/morphological-and-immunohistochemical-analysis-of-the-biocompatibility-of-resin-modified-cements
#5
Janaina Almeida Mesquita, Rogério Lacerda-Santos, Gustavo Pina Godoy, Cassiano Franscisco Weege Nonaka, Pollianna Muniz Alves
The aim of this double-blind randomized study was to evaluate the biocompatibility of resin-modified glass ionomer cements (RMGIC) by means of morphological and immunohistochemical analyses. RMGICs were selected and divided into four groups: Group CK (Crosslink Orthodontic Band Cement); Group RS (Resilience Light Cure Band Cement) Group RMO (RMO Band Cement), Group TP (Transbond Plus Light Cure Band), and Group C (Control-polyethylene). The materials were implanted in rat subcutaneous tissues, randomly selected for this study...
December 28, 2016: Microscopy Research and Technique
https://www.readbyqxmd.com/read/28013567/multinucleate-giant-cell-angiohistiocytoma-of-the-vaginal-wall
#6
Luca Roncati, Francesco Piscioli, Fabrizio Taddei, Teresa Pusiol
No abstract text is available yet for this article.
December 26, 2016: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/27989042/mitraclip%C3%A2-two-weeks-after-implantation
#7
Juliëtte F Velu, Hans H de Boer, Berto J Bouma, Jan Baan
A 73-year-old male received a percutaneous mitral valve repair with a MitraClip to treat severe (grade IV) symptomatic mitral regurgitation (MR). The MitraClip® procedure reduced the MR to grade I, but the patient died 14 days post-procedurally due to a pneumosepsis. Histological analysis of the MitraClip mesh covering showed a chronic inflammatory reaction with an abundance of multinucleated giant cells. Remarkably, signs of early onset clip-coverage were found, indicated by the presence of a few scattered myofibroblasts...
May 2016: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/27987116/roles-of-pkr-in-differentiation-and-apoptosis-of-bone-related-cells
#8
REVIEW
Tatsuji Haneji
Double-stranded RNA-dependent protein kinase (PKR) is a serine/threonine protein kinase which is activated by double-stranded RNAs and related to several signal transduction pathways. To examine the effects of PKR on bone metabolism, we established PKR-K/R mutant cells in which amino acid lysine at 296 is substituted with arginine. PKR regulated apoptosis in osteoblastic cells via nuclear factor kappa-B (NF-κB) cascade. MC3T3-E1 cells cultured with osteoblast differentiation medium differentiated into osteoblasts, while the mutant cells did not differentiate into osteoblasts...
December 16, 2016: Anatomical Science International
https://www.readbyqxmd.com/read/27984690/-pretibial-pseudocyst-after-anterior-cruciate-ligament-reconstruction-with-a-biocomposite-screw
#9
B Alonso, F B Sobrón, C Vidal, J Vaquero
We report the case of a patient who presented a pretibial extra-articular cyst two years after an arthroscopically assisted ACL reconstruction using an autologous bone-patellar tendon-bone graft. The tibial fixation was achieved with a bioabsorbable screw made of poly-L, D-lactic and -tricalcium phosphate (-TCP). A subcutaneous pseudocystic lesion was excised. It consisted of a capsular fibrous tissue with minimal milky fluid (1 ml) centrally. It penetrated into the tibial tunnel but did not communicate with the knee joint space...
May 2016: Acta Ortopédica Mexicana
https://www.readbyqxmd.com/read/27974978/palatal-swelling-a-diagnostic-enigma
#10
Ramalingam Suganya, Narasimhan Malathi, Harikrishnan Thamizhchelvan, Subramaniam Ramkumar, G V V Giri
Giant cell tumor (GCT) of bone is a giant-cell-rich bony lesion associated with abundant multinucleated osteoclast-type giant cells. It is a primary neoplasm of bone with characteristic clinical, radiological, and pathological features. It is an expansive and lytic lesion without periosteal reaction and prominent peripheral sclerosis. Giant cells are also seen in other diseases like giant cell granuloma of the jaws, traumatic bone cyst, aneurysmal bone cyst, and jaw tumor of hyperparathyroidism. We present a unique case of GCT of palate in a 30-year-old female...
2016: Case Reports in Dentistry
https://www.readbyqxmd.com/read/27918730/il-4-induces-the-formation-of-multinucleated-giant-cells-and-expression-of-%C3%AE-5-integrin-in-central-giant-cell-lesion
#11
A Aghbali, S Rafieyan, L Mohamed-Khosroshahi, B Baradaran, D Shanehbandi, M Kouhsoltani
BACKGROUND: It is now well established that IL-4 has a central role in the development of monocytes to multinucleated giant cells (MGCs) by inducing the expression of integrins on the surface of monocytes. The aim of this study was to investigate the potential role of IL-4 in induction of β5 integrin expression in the peripheral blood samples of patients with giant cell granuloma. MATERIAL AND METHODS: Monocytes were isolated from peripheral blood samples of patients with central giant cell granuloma (CGCG) and healthy controls using human Monocyte Isolation Kit II...
January 1, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/27904119/an-autopsy-case-of-amyotrophic-lateral-sclerosis-with-diaphragm-pacing
#12
Hisashi Ito, Tetsumasa Kamei, Sanae Odake, Masayuki Nakano, Riki Okeda, Shunsaku Kohriki, Jun Kawachi, Raymond P Onders, Fumihito Yoshii
Respiratory insufficiency is a critical problem in amyotrophic lateral sclerosis (ALS) patients. We herein present the case of an autopsied patient with sporadic ALS who underwent diaphragm pacing (DP). The pathology showed several localized adhesions with a markedly atrophied diaphragm. A marked loss of motor neurons with Bunina bodies and phosphorylated TDP-43 positive inclusions was found in the spinal cord and primary motor cortex. Mild hyalinization and a few multinucleated giant cells were present around the electrode tracks in the diaphragm...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27902779/differential-cytokine-gene-expression-in-granulomas-from-lungs-and-lymph-nodes-of-cattle-experimentally-infected-with-aerosolized-mycobacterium-bovis
#13
Mitchell V Palmer, Tyler C Thacker, W Ray Waters
The hallmark lesion of tuberculosis in humans and animals is the granuloma. The granuloma represents a distinct host cellular immune response composed of epithelioid macrophages, lymphocytes, and multinucleated giant cells, often surrounding a caseous necrotic core. Within the granuloma, host-pathogen interactions determine disease outcome. Factors within the granulomas such as cytokines and chemokines drive cell recruitment, activity, function and ultimately the success or failure of the host's ability to control infection...
2016: PloS One
https://www.readbyqxmd.com/read/27895169/critical-role-of-ltb4-blt1-in-il-23-induced-synovial-inflammation-and-osteoclastogenesis-via-nf-%C3%AE%C2%BAb
#14
Laura Bouchareychas, Eva M Grössinger, Mincheol Kang, Hong Qiu, Iannis E Adamopoulos
IL-23 activates the synthesis and production of leukotriene B4 (LTB4) in myeloid cells, which modulate inflammatory arthritis. In this study we investigated the role of LTB4 and its receptor LTB4R1 (BLT1) in synovial inflammation and osteoclast differentiation. Specifically, we used IL-23 in vivo gene transfer to induce arthritis in mice and showed that elevated serum LTB4 and synovial expression of 5-lipoxygenase correlated with increased disease severity by histological evaluation and paw swelling compared with GFP gene transfer controls...
January 1, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27894256/burkholderia-pseudomallei-derived-mir-3473-enhances-nf-%C3%AE%C2%BAb-via-targeting-traf3-and-is-associated-with-different-inflammatory-responses-compared-to-burkholderia-thailandensis-in-murine-macrophages
#15
Yao Fang, Hai Chen, Yi Hu, Qian Li, Zhiqiang Hu, Tengfei Ma, Xuhu Mao
BACKGROUND: Burkholderia pseudomallei (Bp) is the causative agent of melioidosis, a kind of tropical disease. Burkholderia thailandensis (Bt), with a high sequence similarity to Bp, is thought to be an avirulent organism. Since there are numerous similarities between Bp and Bt, their differences in pathogenesis of host response and related mechanism are still undermined. In recent years, microRNAs have been researched in many diseases, but seldom involved in bacterial infection, bacteria-host interaction or explaining the differences between virulent and avirulent species...
November 28, 2016: BMC Microbiology
https://www.readbyqxmd.com/read/27891274/a-rare-case-of-lateral-canthal-gouty-tophus-presenting-as-an-eyelid-mass
#16
Austin S Nakatsuka, Timothy F McDevitt, Pamela S Tauchi-Nishi
A 41-year-old man with a history of gout presented with an enlarging eyelid growth. Clinical examination revealed a mildly indurated nodule at the lateral canthus. Following resection, histopathological examination revealed needle-shaped, crystalline material surrounded by multinucleated giant cells, findings consistent with gouty tophus. This represents just the sixth case of gouty tophus of the eyelid reported in the literature.
2016: Case Reports in Ophthalmological Medicine
https://www.readbyqxmd.com/read/27865415/biosterilant-effects-of-bacillus-thuringiensis-kurstaki-hd-73-extract-on-male-wistar-albino-rats
#17
Vikas Kumar Roy, Vanlal Peki, Maibam Sunita Devi, Sanasam Sanjeev, Maurya Khusboo, R Zothansanga, Kalibulla Syed Ibrahim, Nachimuthu Senthil Kumar, Guruswami Gurusubramanian
Chemosterilants have long been used in sterilization programs for managing pet, stray, and wild animals but adverse effects such as trauma, incomplete responses to treatment, and complete abolition of gonadal sources of testosterone often occurs. This study describes the biosterilant effects of administering three doses of Bacillus thuringiensis kurstaki HD-73 (Bt 5, 50, and 250 mg/kg; 20 rats/dose) extract in adult male Wistar albino rats on testicular parameters, function, histology, and a number of biochemical markers of overall health, free radical production, and cell proliferation...
January 15, 2017: Theriogenology
https://www.readbyqxmd.com/read/27862483/cytological-features-of-solid-variants-of-papillary-thyroid-carcinoma-a-fine-needle-aspiration-cytology-study-of-18-cases
#18
M Higuchi, M Hirokawa, A Suzuki, N Takada, N Yamao, S Kuma, A Miyauchi
OBJECTIVE: Solid variants of papillary thyroid carcinoma (SV-PTC) are rare, and there have been few reports describing the cytological findings of such variants. METHODS: The cytological features of cellular specimens aspirated from 18 histologically confirmed SV-PTC cases were evaluated, retrospectively. RESULTS: Solid and small papillary clusters were observed in 14 (77.8%) and 13 (72.2%) cases, respectively. The incidences of large papillary clusters (11...
November 13, 2016: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/27861333/isolated-neurosarcoidosis-mimicking-multifocal-meningiomas-a-diagnosis-pitfall-a-case-report
#19
Kun Wang, Xiaoying He, Wei Wang, Huanjiang Niu, Yirong Wang, Xiujun Cai, Shuxu Yang
INTRODUCTION: Neurosarcoidosis accounts for approximately 5% of the sarcoidosis, which develops exclusively in the nervous system and is always difficult to diagnose. We describe a rare case of isolated neurosarcoidosis mimicking as multifocal meningiomas. A 27-year-old male was admitted to our hospital with a history of unconsciousness and convulsion 1 month ago, which was suspected as a seizure. The results showed no abnormalities in complete blood count; serum electrolytes; erythrocyte sedimentation rate and ultrasonography of the liver, pancreas, spleen, kidney and parotid gland, and so on...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27821229/-clinicopathologic-features-of-dermal-nerve-sheath-myxoma-and-neurothekeoma-a-comparative-study
#20
H Ding, L L Wang, X L Xu, Q Y Lao I, L Yu, J Wang
Objective: To investigate the clinicopathologic characteristics and differential diagnosis of dermal nerve sheath myxoma (DNSM) and neurothekeoma (NTK). Methods: Clinical, pathological features and immunohistochemical profiles in 9 cases of DNSM and 8 cases of NTK were comparatively studied. The literature was reviewed. Results: The involved site of 9 DNSMs included the hand/fingers (n=3), ear (n=2), face, back, abdominal wall and waist (1 case each). Two of 8 NTKs arose in the forearm (n=2), one each in the nose, lip, shoulder, supraclavicular region, leg and hand...
November 8, 2016: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
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