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Multinucleated giant cells

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https://www.readbyqxmd.com/read/28937375/superficial-cd34-positive-fibroblastic-tumor-a-new-entity-case-report-and-review-of-literature
#1
Neelam Sood, Binit Kumar Khandelia
Earlier, categorized under low grade malignant fibrous histiocytoma and low grade sarcomas, 'superficial CD34 positive fibroblastic tumor', a newly proposed entity, is a low grade mesenchymal tumor of intermediate malignant potential. Morphological features include monomorphic neoplastic spindle cells arranged in a fascicular to storiform pattern along with sheets of pleomorphic epithelioid cells, and multinucleated giant cells with glassy cytoplasm. Diffuse vimentin and characteristic diffuse CD34 positivity is seen in all cases with few showing focal cytokeratin expression...
July 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/28892910/benign-fibrous-histiocytoma-an-uncommon-presentation
#2
Sagarika Sarkar, Moumita Maiti, Palas Bhattacharyya, Ranu Sarkar
Intracranial fibrous histiocytomas are rare; Benign Fibrous Histiocytoma (BFH) being uncommon than its malignant counterpart. BFH comprises fibroblasts and histiocytes without any nuclear pleomorphism or atypia. We present a case of a 42-year-old male who had swelling over the occipital region for the past five years, which progressively increased in size. He developed headache, dizziness, and gait disturbance over the last six months. Computed tomographic scan revealed a posterior fossa space-occupying lesion...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28875521/chronic-myocarditis-with-a-long-clinical-course-report-of-an-autopsy-case-of-probable-autoimmune-myocarditis
#3
Masayuki Shintaku, Koji Uchiyama, Yohei Kobayashi
The patient was a 54-year-old woman, who died of chronic cardiac insufficiency after a clinical course of 2 years and 4 months. She had complained of myalgia, muscle weakness, and blepharoptosis before the onset of cardiac symptoms, but there was no evidence of myasthenia gravis or collagen-vascular diseases. At autopsy, the heart (280 g) showed marked dilatation of the four chambers and thinning of the ventricular walls. Diffuse and intense lymphocytic infiltration and extensive fibrosis were noted, with the latter being accentuated in the subendocardial and subepicardial zones...
September 6, 2017: Pathology International
https://www.readbyqxmd.com/read/28857979/coccidioidomycosis-involving-lungs-and-skin-a-mimicker-of-metastatic-disease
#4
Barbara Saenz-Ibarra, Victor G Prieto, Carlos A Torres-Cabala, Auris Huen, Priyadharsini Nagarajan, Michael T Tetzlaff, Jonathan L Curry, Doina Ivan, Phyu P Aung
Coccidioidomycosis is the major systemic mycoses, considered to be 1 of the most infectious fungal diseases. In symptomatic patients, the most common manifestation is pulmonary disease, but many other organs can be affected. Disseminated disease occurs in 1%-5% of all patients affected by coccidioidomycosis and can affect any organ, with the skin, central nervous system, and musculoskeletal system being reported as the most prevalent. Here, we report a 42-year-old male farmer from the west Texas who presented with an approximately 2-month history of progressive shortness of breath and dyspnea on exertion, weight loss, and night sweats...
August 24, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28854186/meloidogyne-aberrans-sp-nov-nematoda-meloidogynidae-a-new-root-knot-nematode-parasitizing-kiwifruit-in-china
#5
Ye Tao, Chunling Xu, Chunfen Yuan, Honghong Wang, Borong Lin, Kan Zhuo, Jinling Liao
High infection rates of roots of wild kiwifruit (Actinidia chinensis Planch) and soil infestation by a root-knot nematode were found in Anshun, GuiZhou Province, China. Morphology, esterase phenotype and molecular analyses confirmed that this nematode was different from previously described root-knot nematodes. In this report, the species is described, illustrated and named Meloidogyne aberrans sp. nov. The new species has a unique combination of characters. A prominent posterior protuberance, round and faint perineal pattern and a medium-length stylet (13...
2017: PloS One
https://www.readbyqxmd.com/read/28852357/influence-of-45s5-bioactive-glass-in-a-standard-calcium-phosphate-collagen-bone-graft-substitute-on-the-posterolateral-fusion-of-rabbit-spine
#6
Andrew J Pugely, Emily B Petersen, Nicole DeVries-Watson, Douglas C Fredericks
INTRODUCTION: Spinal fusion surgery is an effective but costly treatment for select spinal pathology. Historically iliac crest bone graft (ICBG) has remained the gold standard for achieving successful arthrodesis. Given well-established morbidity autograft harvest, multiple bone graft replacements, void fillers, and extenders have been developed. The objective of this study was to evaluate the in vivo efficacy and safety of two mineralized collagen bone void filler materials similar in composition...
2017: Iowa Orthopaedic Journal
https://www.readbyqxmd.com/read/28851664/pediatric-soft-tissue-tumor-of-the-upper-arm-with-lmna-ntrk1-fusion
#7
Shinji Kohsaka, Tsuyoshi Saito, Keisuke Akaike, Yoshiyuki Suehara, Takuo Hayashi, Tatsuya Takagi, Kazuo Kaneko, Toshihide Ueno, Shinya Kojima, Ken-Ichi Kohashi, Hiroyuki Mano, Yoshinao Oda, Takashi Yao
A 6-year-old girl was admitted to our hospital due to the presence of a slow-growing tumor in her right elbow. Biopsy specimens showed a round- to spindle-cell neoplasm with uncertain malignant potential, leading to the decision of surgical resection. Histologically, the resected tumor was encapsulated by fibrous tissue, but focally invaded the surrounding skeletal muscles. The tumor was composed of ganglion-cell-like short spindle cells with lymphocytic infiltration in the collagenous background. Tumor cells with large bizarre nuclei were occasionally observed, and multinucleated giant cells were scattered at the periphery...
August 26, 2017: Human Pathology
https://www.readbyqxmd.com/read/28846198/cysticercosis-reiterating-the-role-of-cytodiagnosis
#8
Shweta Pal, Neha Singh, Nilotpal Chowdhury, Farhanul Huda, Shalinee Rao
BACKGROUND: Cysticercosis is a common parasitic infection in many Asian countries. The histopathological features of this parasitic infection are well established, however, the subtle cytological features and their importance in diagnosing this condition need more elaboration. In this case series we have reiterated the role of fine-needle aspiration cytology (FNAC) in the diagnosis of cysticercosis in clinically unsuspected cases, thereby obviating the need for a biopsy. METHODS: Sixteen patients presented with palpable subcutaneous swellings...
August 28, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28836691/disseminated-cutaneous-mycobacterium-kansasii-infection-presenting-with-rosai-dorfman-disease-like-histological-features-in-a-patient-carrying-anti-interferon-%C3%AE-autoantibodies
#9
Yih-An King, Chung-Hong Hu, Yuarn-Jang Lee, Chiou-Feng Lin, Donald Liu, Kuo-Hsien Wang
Typical cutaneous non-tuberculous mycobacteria (NTM) infections show a histopathology pattern of granulomas with admixed Langhans giant cells, and abscesses may be observed in acute lesions. Herein, we describe a patient carrying a high titer of autoantibodies to interferon (IFN)-γ with disseminated Mycobacterium kansasii infection presenting with emperipolesis and Rosai-Dorfman disease (RDD)-like histopathological features characterized by remarkable, large, pale-staining "RD cells", which were CD68 and S100 positive and CD1a negative...
August 24, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28835938/valproic-acid-induces-histologic-changes-and-decreases-androgen-receptor-levels-of-testis-and-epididymis-in-rats
#10
Sitthichai Iamsaard, Wannisa Sukhorum, Supatcharee Arun, Nichapa Phunchago, Nongnuch Uabundit, Porntip Boonruangsri, Malivalaya Namking
BACKGROUND: Valproic acid (VPA), an anti-epileptic drug, can cause male subfertility. However, the degree to which testicular and epididymal histopathologies and androgen receptor (AR) expression are changed under VPA treatment has never been reported. OBJECTIVE: To investigate the histopathological changes and AR protein levels of testis and epididymis in VPA-treated rats for every single day. MATERIALS AND METHODS: Sixty-four adult male Wistar rats were divided into control and VPA-treated groups (n=8/ each)...
April 2017: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/28832079/are-cd68-and-factor-viii-ra-expression-different-in-central-and-peripheral-giant-cell-granuloma-of-jaw-an-immunohistochemical-comparative-study
#11
Soudabeh Sargolzaei, Nasim Taghavi, Farzaneh Poursafar
OBJECTIVE: Central giant cell granuloma and peripheral giant cell granuloma of the jaw and oral cavity are identical in histopathologic features, although they are different in pathogenesis and clinical behavior. The aim of present study was to compare CD 68 and factor VIII related antigen (VIII-RA ) immunoreactivity in central giant cell granuloma and peripheral giant cell granuloma to determine the biologic nature and clinical behavior of these lesions which may lead to a better or new treatment modality...
2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28829109/adult-orbital-and-adnexal-xanthogranulomatous-disease
#12
Michael J Davies, Kevin Whitehead, Gary Quagliotto, Dominic Wood, Rajan S Patheja, Timothy J Sullivan
PURPOSE: Adult xanthogranulomatous disease of the orbit and ocular adnexa is a rare disease that can cause serious morbidity and mortality. Ophthalmologists are commonly the first clinicians to come in contact with affected patients and an understanding of the clinical features is essential. DESIGN: We present a retrospective case series of patients seen in the oculoplastic unit of a large tertiary referral hospital over a 20-year period. METHODS: The clinical files of 7 patients with adult xanthogranulomatous disease of the orbit and ocular adnexa were reviewed...
August 22, 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28810997/cutaneous-leishmaniasis-in-a-saudi-arabian-soldier-stationed-in-the-united-states
#13
Kelly Laurent, Jason Susong, Eric Fillman, Simon Ritchie
BACKGROUND: Leishmaniasis is a common parasitic disease seen in many parts of the world, especially in areas where current U.S. and international forces are deployed. Approximately 350 million people are thought to be at risk of cutaneous leishmaniasis (CL) with an annual incidence of 1.5 million cases. Over 90% of cutaneous infections with Leishmania occur in the Middle East, Brazil, and Peru. Outbreaks of CL may occur in military personnel deployed to endemic areas. Since the incubation period for symptomatic CL ranges from weeks to months, symptoms may not appear until well after returning to the United States...
July 2017: Military Medicine
https://www.readbyqxmd.com/read/28808515/palpitations-as-a-presenting-feature-of-multisystem-sarcoidosis
#14
Richie Manikat, Julieta Gilson, Mahesh Krishnamurthy, Koroush Khalighi
Introduction: Sarcoidosis is described as a systemic condition characterized by non-caseating granulomas in multiple organs. In this report, we present an unusual manifestation of cardiac sarcoidosis and review management strategies. Case presentation: A 29-year-old African-American man presented with weight loss, fatigue, dyspnea, palpitations, night sweats, painless left eye redness and bilateral leg pain over the course of three months. His physical exam revealed left conjunctival congestion and bilateral crackles on auscultation...
July 2017: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/28798870/histopathological-and-imageological-studies-on-clinical-outcomes-of-mineralized-collagen-reconstruction-rod-for-femoral-head-necrosis-with-one-case-report
#15
Baogang Xie, Hao Wang, Jianhua Hao, Ping Wang, Na Zhang, Jingjing Wu, Zhiye Qiu, Fuzhai Cui
In this article, the biodegradation process and bone formation of a mineralized collagen reconstruction rod embedding in necrosis of human femoral head were investigated by imageological and histological methods. Computed radiography (CR) computerized tomography (CT), common pathological section and hard tissue section analysis were used to evaluated the dynamics of imageological and histopathological changes of femoral head, interface between the host bone and implant and the bone reconstruction process. The results showed that the density of rods increased closed to that of host bones after 1 year implanting, and the interface between them turns to blurring...
August 2017: Regenerative Biomaterials
https://www.readbyqxmd.com/read/28793791/idiopathic-giant-cell-granuloma-in-the-saddle-area-recurring-soon-after-subtotal-resection-a-case-report
#16
Renling Mao, Jian Li, Yanping Ren, Jiang Feng, Li Xiao, Yu Duan
Giant cell granuloma is non-neoplastic proliferation of multinucleated giant cells and rarely occurs in the intracranial space. Here we report a 40-year-old man presented with left ptosis and impaired vision. Magnetic resonance imaging revealed a mass extending from the intrasellar area to the third ventricular floor, left cavernous sinus, retrochiasmatic area, and the left interpeduncular cistern. The lesion was subtotally resected using the transsphenoidal approach. Three months after the operation, the mass recurred and hormone levels decreased significantly...
August 9, 2017: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/28791997/-eosinophilic-granuloma-of-the-parietal-bone-of-an-adult-patient-with-braf-mutation
#17
O V Dolzhansky, E M Paltseva, A A Bukaeva, E V Zaklyazminskaya, I A Spivak, D N Fedorov
The paper describes a case of eosinophilic granuloma of the parietal bone in a 32-year-old man. Histological examination revealed a large number of bean-shaped Langerhans cell histiocytes with lobed nuclei and nuclear grooves. The histiocytes alternated with the foci of obvious eosinophilic infiltration and with eosinophilic microabscesses. There were osteoclast-like multinucleated giant cells, bone resorption, and numerous bone rods covered with osteoblast chains. The histiocytes expressed CD1α, langerin, CD68, S100, and p53 (in 90...
2017: Arkhiv Patologii
https://www.readbyqxmd.com/read/28781324/treatment-of-fulminant-giant-cell-myocarditis-associated-with-polymyositis-using-a-left-ventricular-assist-device-and-subsequent-corticosteroid-and-immunosuppressive-therapy-leading-to-remission
#18
Junichi Ooka, Hidekazu Tanaka, Yutaka Hatani, Yukio Tsuji, Ryo Takeshige, Shumpei Mori, Kensuke Matsumoto, Shigeo Hara, Hiroshi Tanaka, Yutaka Okita, Ken-Ichi Hirata
A 58-year-old man with a recent history of generalized myalgia and muscle weakness was transferred to our hospital because of acute progressive dyspnea. The patient underwent left ventricular (LV) assist device (LVAD) implantation due to cardiogenic shock with a LV ejection fraction (LVEF) of 6%. The histological findings obtained from LV apex showed the infiltration of multinucleated giant cells and severe myocardial contusion. Combining this histological finding with our experienced neurologists comments, resulted in a final diagnosis of fulminant giant cell myocarditis associated with polymyositis...
August 15, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28768982/multicentric-reticulohistiocytosis-with-dermatomyositis-like-eruptions
#19
Natsuki Shima, Takamasa Murosaki, Takao Nagashima, Masahiro Iwamoto, Yusuke Amano, Naomi Nakano, Mamitaro Ohtsuki, Seiji Minota
A 68-year-old man presented with polyarthritis, proximal muscle weakness, and erythema of the face, arms, neck, and anterior chest that resembled the V-neck sign. Initially, dermatomyositis (DM) was considered because of the erythema, polyarthritis, and muscle weakness. He also had mediastinal and hilar lymphadenopathy on contrast-enhanced computed tomography. Unexpectedly, a biopsy of the forehead skin revealed numerous multinucleated giant cells. A biopsy of a solitary nodule on the dorsum of his right middle finger revealed similar multinucleated giant cells with ground-glass cytoplasm, leading to the diagnosis of multicentric reticulohistiocytosis (MRH)...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28761846/phaeohyphomycosis-of-the-face-masquerading-as-basal-cell-carcinoma-in-an-immunocompetent-patient
#20
Sharma Shruti, Avninder Singh, V Ramesh, Fouzia Siraj
Pheohyphomycosis is a rare heterogeneous group of mycotic infections caused by dermatiaceous (phaeoid) fungi affecting the skin, subcutaneous tissue, and the central nervous system.Involvement of the face is extremely rare, and very few cases have been reported in India so far. We reporta case of phaeohyphomycosisin a 45-year-old female with 1-year history of a well- defined hypertrophic plaque over the right cheek advancing towards the forehead. The lesion was ulcerated with rolled-up margins; a provisional clinical diagnosis of basal cell carcinoma was given...
July 2017: Indian Dermatology Online Journal
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