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Multinucleated giant cells

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https://www.readbyqxmd.com/read/27918730/il-4-induces-the-formation-of-multinucleated-giant-cells-and-expression-of-%C3%AE-5-integrin-in-central-giant-cell-lesion
#1
A Aghbali, S Rafieyan, L Mohamed-Khosroshahi, B Baradaran, D Shanehbandi, M Kouhsoltani
BACKGROUND: It is now well established that IL-4 has a central role in the development of monocytes to multinucleated giant cells (MGCs) by inducing the expression of integrins on the surface of monocytes. The aim of this study was to investigate the potential role of IL-4 in induction of β5 integrin expression in the peripheral blood samples of patients with giant cell granuloma. MATERIAL AND METHODS: Monocytes were isolated from peripheral blood samples of patients with central giant cell granuloma (CGCG) and healthy controls using human Monocyte Isolation Kit II...
December 6, 2016: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/27904119/an-autopsy-case-of-amyotrophic-lateral-sclerosis-with-diaphragm-pacing
#2
Hisashi Ito, Tetsumasa Kamei, Sanae Odake, Masayuki Nakano, Riki Okeda, Shunsaku Kohriki, Jun Kawachi, Raymond P Onders, Fumihito Yoshii
Respiratory insufficiency is a critical problem in amyotrophic lateral sclerosis (ALS) patients. We herein present the case of an autopsied patient with sporadic ALS who underwent diaphragm pacing (DP). The pathology showed several localized adhesions with a markedly atrophied diaphragm. A marked loss of motor neurons with Bunina bodies and phosphorylated TDP-43 positive inclusions was found in the spinal cord and primary motor cortex. Mild hyalinization and a few multinucleated giant cells were present around the electrode tracks in the diaphragm...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27902779/differential-cytokine-gene-expression-in-granulomas-from-lungs-and-lymph-nodes-of-cattle-experimentally-infected-with-aerosolized-mycobacterium-bovis
#3
Mitchell V Palmer, Tyler C Thacker, W Ray Waters
The hallmark lesion of tuberculosis in humans and animals is the granuloma. The granuloma represents a distinct host cellular immune response composed of epithelioid macrophages, lymphocytes, and multinucleated giant cells, often surrounding a caseous necrotic core. Within the granuloma, host-pathogen interactions determine disease outcome. Factors within the granulomas such as cytokines and chemokines drive cell recruitment, activity, function and ultimately the success or failure of the host's ability to control infection...
2016: PloS One
https://www.readbyqxmd.com/read/27895169/critical-role-of-ltb4-blt1-in-il-23-induced-synovial-inflammation-and-osteoclastogenesis-via-nf-%C3%AE%C2%BAb
#4
Laura Bouchareychas, Eva M Grössinger, Mincheol Kang, Hong Qiu, Iannis E Adamopoulos
IL-23 activates the synthesis and production of leukotriene B4 (LTB4) in myeloid cells, which modulate inflammatory arthritis. In this study we investigated the role of LTB4 and its receptor LTB4R1 (BLT1) in synovial inflammation and osteoclast differentiation. Specifically, we used IL-23 in vivo gene transfer to induce arthritis in mice and showed that elevated serum LTB4 and synovial expression of 5-lipoxygenase correlated with increased disease severity by histological evaluation and paw swelling compared with GFP gene transfer controls...
November 28, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27894256/burkholderia-pseudomallei-derived-mir-3473-enhances-nf-%C3%AE%C2%BAb-via-targeting-traf3-and-is-associated-with-different-inflammatory-responses-compared-to-burkholderia-thailandensis-in-murine-macrophages
#5
Yao Fang, Hai Chen, Yi Hu, Qian Li, Zhiqiang Hu, Tengfei Ma, Xuhu Mao
BACKGROUND: Burkholderia pseudomallei (Bp) is the causative agent of melioidosis, a kind of tropical disease. Burkholderia thailandensis (Bt), with a high sequence similarity to Bp, is thought to be an avirulent organism. Since there are numerous similarities between Bp and Bt, their differences in pathogenesis of host response and related mechanism are still undermined. In recent years, microRNAs have been researched in many diseases, but seldom involved in bacterial infection, bacteria-host interaction or explaining the differences between virulent and avirulent species...
November 28, 2016: BMC Microbiology
https://www.readbyqxmd.com/read/27891274/a-rare-case-of-lateral-canthal-gouty-tophus-presenting-as-an-eyelid-mass
#6
Austin S Nakatsuka, Timothy F McDevitt, Pamela S Tauchi-Nishi
A 41-year-old man with a history of gout presented with an enlarging eyelid growth. Clinical examination revealed a mildly indurated nodule at the lateral canthus. Following resection, histopathological examination revealed needle-shaped, crystalline material surrounded by multinucleated giant cells, findings consistent with gouty tophus. This represents just the sixth case of gouty tophus of the eyelid reported in the literature.
2016: Case Reports in Ophthalmological Medicine
https://www.readbyqxmd.com/read/27865415/biosterilant-effects-of-bacillus-thuringiensis-kurstaki-hd-73-extract-on-male-wistar-albino-rats
#7
Vikas Kumar Roy, Vanlal Peki, Maibam Sunita Devi, Sanasam Sanjeev, Maurya Khusboo, R Zothansanga, Kalibulla Syed Ibrahim, Nachimuthu Senthil Kumar, Guruswami Gurusubramanian
Chemosterilants have long been used in sterilization programs for managing pet, stray, and wild animals but adverse effects such as trauma, incomplete responses to treatment, and complete abolition of gonadal sources of testosterone often occurs. This study describes the biosterilant effects of administering three doses of Bacillus thuringiensis kurstaki HD-73 (Bt 5, 50, and 250 mg/kg; 20 rats/dose) extract in adult male Wistar albino rats on testicular parameters, function, histology, and a number of biochemical markers of overall health, free radical production, and cell proliferation...
January 15, 2017: Theriogenology
https://www.readbyqxmd.com/read/27862483/cytological-features-of-solid-variants-of-papillary-thyroid-carcinoma-a-fine-needle-aspiration-cytology-study-of-18-cases
#8
M Higuchi, M Hirokawa, A Suzuki, N Takada, N Yamao, S Kuma, A Miyauchi
OBJECTIVE: Solid variants of papillary thyroid carcinoma (SV-PTC) are rare, and there have been few reports describing the cytological findings of such variants. METHODS: The cytological features of cellular specimens aspirated from 18 histologically confirmed SV-PTC cases were evaluated, retrospectively. RESULTS: Solid and small papillary clusters were observed in 14 (77.8%) and 13 (72.2%) cases, respectively. The incidences of large papillary clusters (11...
November 13, 2016: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/27861333/isolated-neurosarcoidosis-mimicking-multifocal-meningiomas-a-diagnosis-pitfall-a-case-report
#9
Kun Wang, Xiaoying He, Wei Wang, Huanjiang Niu, Yirong Wang, Xiujun Cai, Shuxu Yang
INTRODUCTION: Neurosarcoidosis accounts for approximately 5% of the sarcoidosis, which develops exclusively in the nervous system and is always difficult to diagnose. We describe a rare case of isolated neurosarcoidosis mimicking as multifocal meningiomas. A 27-year-old male was admitted to our hospital with a history of unconsciousness and convulsion 1 month ago, which was suspected as a seizure. The results showed no abnormalities in complete blood count; serum electrolytes; erythrocyte sedimentation rate and ultrasonography of the liver, pancreas, spleen, kidney and parotid gland, and so on...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27821229/-clinicopathologic-features-of-dermal-nerve-sheath-myxoma-and-neurothekeoma-a-comparative-study
#10
H Ding, L L Wang, X L Xu, Q Y Lao I, L Yu, J Wang
Objective: To investigate the clinicopathologic characteristics and differential diagnosis of dermal nerve sheath myxoma (DNSM) and neurothekeoma (NTK). Methods: Clinical, pathological features and immunohistochemical profiles in 9 cases of DNSM and 8 cases of NTK were comparatively studied. The literature was reviewed. Results: The involved site of 9 DNSMs included the hand/fingers (n=3), ear (n=2), face, back, abdominal wall and waist (1 case each). Two of 8 NTKs arose in the forearm (n=2), one each in the nose, lip, shoulder, supraclavicular region, leg and hand...
November 8, 2016: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/27810640/skeletal-muscle-derived-stem-cells-microintegrated-into-a-biodegradable-elastomer-for-reconstruction-of-the-abdominal-wall
#11
Keisuke Takanari, Ryotaro Hashizume, Yi Hong, Nicholas J Amoroso, Tomo Yoshizumi, Burhan Gharaibeh, Osamu Yoshida, Kazuhiro Nonaka, Hideyoshi Sato, Johnny Huard, William R Wagner
A variety of techniques have been applied to generate tissue engineered constructs, where cells are combined with degradable scaffolds followed by a period of in vitro culture or direct implantation. In the current study, a cellularized scaffold was generated by concurrent deposition of electrospun biodegradable elastomer (poly(ester urethane)urea, PEUU) and electrosprayed culture medium + skeletal muscle-derived stem cells (MDSCs) or electrosprayed culture medium alone as a control. MDSCs were obtained from green fluorescent protein (GFP) transgenic rats...
October 18, 2016: Biomaterials
https://www.readbyqxmd.com/read/27806841/diagnostic-pitfalls-of-infarcted-warthin-tumor-in-frozen-section-evaluation
#12
Yaohong Tan, Oleksandr N Kryvenko, Darcy A Kerr, Jennifer R Chapman, Christina Kovacs, David J Arnold, Andrew E Rosenberg, Carmen R Gomez-Fernandez
Warthin tumor (WT) is the second most common benign salivary gland neoplasm and has characteristic cytologic and histologic findings. Fine-needle aspiration is a common and useful preoperative diagnostic technique, which sometimes leads to ischemic injury resulting in the infarction of these lesions. Infarcted WT may demonstrate variable gross and histologic alterations that may render the diagnosis challenging, particularly during intraoperative frozen section evaluation. In this study, we collected 11 resection specimens from 9 patients with infarcted WT...
December 2016: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/27799978/multifocal-central-giant-cell-granuloma-a-case-report
#13
Tamgadge Sandhya, Tamgadge Avinash, Dhauskar Snehal, Tiwari Neha, Mudaliar Uma
Central giant cell granuloma is a benign, aggressive neoplasm composed of multinucleated giant cells that almost exclusively occurs in the jaws though extra- gnathic incidence is rare. Multifocal CGCGs of the jaws are very rare and suggestive of systemic diseases such as hyperparathyroidism, an inherited syndrome such as Noonan- like multiple giant cell lesion syndrome or other disorders.Very few cases of multifocal CGCGs in the jaws without any concomitant systemic disease have been reported. This paper describes an unusual case reported to the Oral Surgery Department of Dr...
2016: Iranian Journal of Pathology
https://www.readbyqxmd.com/read/27770108/histological-development-of-male-reproductive-organs-in-microminipigs
#14
Akihisa Kangawa, Masayoshi Otake, Satoko Enya, Toshinori Yoshida, Masatoshi Shibata
Microminipigs are becoming increasingly attractive alternatives for various experimental applications, such as general toxicology studies, owing to their manageable size. However, there are limited studies on the male reproductive organs of microminipigs, particularly on the histological aspects of sexual maturity. To clarify the development of male reproductive organs, 35 male microminipigs, aged 0 to 12 months, were used in this study. Histological and histomorphological evaluation was performed based on spermatogenic development, measurement of tubular structure in testes and epididymides, and histological progress of accessory glands...
October 21, 2016: Toxicologic Pathology
https://www.readbyqxmd.com/read/27761885/diagnostic-assessment-of-intraoperative-cytology-for-papillary-thyroid-carcinoma-using-a-decision-tree-analysis
#15
J-S Pyo, J H Sohn, G Kang
PURPOSE: The aim of this study was to elucidate the cytological characteristics and the diagnostic usefulness of intraoperative cytology (IOC) for papillary thyroid carcinoma (PTC). In addition, using decision tree analysis, effective features for accurate cytological diagnosis were sought. METHODS: We investigated cellularity, cytological features and diagnosis based on the Bethesda System for Reporting Thyroid Cytopathology in IOC of 240 conventional PTCs. The cytological features were evaluated in terms of nuclear score with nuclear features, and additional figures such as presence of swirling sheets, psammoma bodies, and multinucleated giant cells...
October 19, 2016: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/27758997/spontaneous-resolution-of-a-tumor-like-pulmonary-sarcoidosis
#16
Zied Moatemri, Ghassen Soussi, Salsabil Dabboussi, Samira Mhamdi, Chiraz Aichaouia, Mohsen Khadraoui, Rezaik Cheikh
We report a case of thoracic sarcoidosis in a 72-year-old female, snuff taker, who presented with multinodular pulmonary lesions on chest x-ray. Clinical and biological findings were poor. Thoracic imaging showed soft tissue density nodules with irregular borders. The diagnosis of 'cannon ball' metastases was suspected. A thorough investigation strategy could not prove malignancy. A complete radiologic clearing was obtained spontaneously within three months. A rereading of pathology slides performed afterwards showed multinucleated giant cells on hemorrhagic background with a lymphocytic alveolitis...
October 7, 2016: Sarcoidosis, Vasculitis, and Diffuse Lung Diseases: Official Journal of WASOG
https://www.readbyqxmd.com/read/27756982/fine-needle-aspiration-study-of-cystic-papillary-thyroid-carcinoma-rare-cytological-findings
#17
Maral Mokhtari, Perikala Vijayananda Kumar, Kamran Hayati
BACKGROUND: Cystic papillary thyroid carcinoma (CPTC) is a variant of papillary carcinoma that has many mimickers in cytological grounds. AIM: To study the cytomorphologic features of CPTC and compare them to those of other cystic thyroid lesions using fine-needle aspiration cytology (FNAC). We also aimed to identify the cytomorphologic features that distinguish CPTC from other cystic thyroid lesions. MATERIALS AND METHODS: Seventy-three cases of CPTC were included in the study...
July 2016: Journal of Cytology
https://www.readbyqxmd.com/read/27749194/sheep-associated-malignant-catarrhal-fever-like-skin-disease-in-a-free-ranging-bighorn-sheep-ovis-canadensis-alberta-canada
#18
Owen M Slater, Jeanine Peters-Kennedy, Manigandan Lejeune, David Gummer, Bryan Macbeth, Amy Warren, Tomy Joseph, Hong Li, Cristina W Cunha, Pádraig J Duignan
Malignant catarrhal fever-like clinical disease was diagnosed in a free-ranging bighorn sheep ( Ovis canadensis ) from Alberta, Canada, in June 2015. Antemortem and gross pathology findings included muscle atrophy, marked weight loss, and bilaterally symmetric alopecia with hyperpigmentation and crusting over the face, medial surfaces of the pinnae, dorsal trunk, distal limbs, perineal area, and tail. Histologically, the skin lesions were characterized by granulomatous mural folliculitis with numerous multinucleated giant cells and fewer lymphocytes and eosinophils consistent with previous reports of chronic ovine herpesvirus-2 (OvHV-2) infection...
October 17, 2016: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/27746622/giant-cell-hepatitis-rare-entity-in-adults
#19
Shiran Shetty, Krishnaveni Janarthanan, Venkatakrishnan Leelakrishnan, Vadakkepat Nirmala
Giant-cell hepatitis (GCH) is characterized by parenchymal inflammation with formation of large multinucleated hepatocytes in response to a variety of insults to the liver. Although it is commonly described in neonates, it rarely occurs in adults. Here we report a case of GCH because of herbal medicine intake.
September 2016: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/27746414/hematological-and-pathological-features-of-massive-hepatic-necrosis-in-two-radiated-tortoises-astrochelys-radiata
#20
Nobuhide Kido, Iori Itagaki, Daisuke Kiryu, Tomoko Omiya, Kaori Ono
Two radiated tortoises (Astrochelys radiata) exhibited anorexia and hypokinesia. In both cases, hematological and serum biochemical examinations revealed high alkaline phosphatase levels, moderately high aspartate aminotransferase levels and white blood cell counts approximately within the normal range. Despite being treated, the tortoises died 9 and 43 days after the first clinical examination. Gross pathological examinations revealed that the livers of both animals were extremely swollen and contained pale yellow necrotic tissue...
October 16, 2016: Journal of Veterinary Medical Science
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