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Multinucleated giant cells

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https://www.readbyqxmd.com/read/29771688/plexiform-atypical-spitz-tumor-with-rosette-like-giant-cells-a-histologic-and-immunohistochemical-study-on-a-case-suggesting-ganglioneuroblastic-differentiation-review-of-the-literature-and-considerations-on-histogenesis
#1
Elena Castelli, Elisabetta Orlando, Giuseppe Pistone, Maria R Bongiorno
Spitz nevi, atypical Spitz tumors and Spitzoid melanoma, the three clinicopathologic forms that constitute the spectrum of the Spitz-type melanocytic lesions, share a histologic picture characterized by large spindle and/or epithelioid ganglion-like cells, with various admixtures of multinucleate bizarre cells. This remarkable cytology has always been interpreted as an unusual, as well as unexplained form of atypia. We report a case of atypical Spitz tumor with Homer Wright-like rosettes, a feature characteristic of ganglioneuroblastic proliferation...
May 16, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29755271/clinical-radiological-and-histopathological-characteristics-of-surgically-removed-orbital-hematic-cysts-a-case-series
#2
Hind M Alkatan, Mohammad Al Otaibi, Azza M Y Maktabi, Hamad Aljaedi, Sahar M Elkhamary, Yasser Al-Faky, Adel H Alsuhaibani
Background: Hematic cyst is a rare orbital condition that has a wide range of clinical presentation and is characterized pathologically by lack of endothelial lining. Purpose: To correlate clinical and radiological features of hematic cysts, to tissue diagnosis, and investigate the possible etiology behind this condition, its relation to trauma and other interesting histopathological findings. Methods: Retrospective case series at King Khaled Eye Specialist Hospital (KKESH) and King Abdulaziz University Hospital (KAUH) of all orbital lesions with tissue findings supporting the clinical and/or radiological diagnosis of hematic cyst...
January 2018: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/29749998/morphological-and-immunohistochemical-diversity-of-endometrial-stromal-sarcoma-in-rats
#3
Shino Kumabe, Junko Sato, Yuki Tomonari, Miwa Takahashi, Kaoru Inoue, Midori Yoshida, Takuya Doi, Yumi Wako, Minoru Tsuchitani
To clarify the histopathological characteristics of rat endometrial stromal sarcoma (ESS), we morphologically reviewed 12 malignant uterine tumors protruding into the lumen in previous rat carcinogenicity studies. The 12 cases were classified into the following 6 types based on their morphological features: spindle cell and collagen rich type, pleomorphic/spindle cell and compact type, decidual alteration type, histiocytic and multinucleated giant cell mixture type, Antoni A-type schwannoma type, and Antoni B-type schwannoma type...
April 2018: Journal of Toxicologic Pathology
https://www.readbyqxmd.com/read/29743202/macrophages-and-dendritic-cells-are-the-predominant-cells-infected-in-measles-in-humans
#4
Ingrid V Allen, Stephen McQuaid, Rosana Penalva, Martin Ludlow, W Paul Duprex, Bertus K Rima
Characterization of human measles cases is essential in order to better assess the data generated in model systems of morbillivirus infection. To this end, we collected formalin-fixed tissue samples from 23 natural measles cases from different areas in the world and different phases of disease ranging from prodromal and acute measles to a persistent infection in an immunocompromised subject. We show that the vast majority of measles virus (MV)-infected cells in epithelia were intraepithelial immune cells that were, in most cases, positive for the CD11c myeloid cell marker...
June 27, 2018: MSphere
https://www.readbyqxmd.com/read/29742062/global-perspective-of-novel-therapeutic-strategies-for-the-management-of-neuroaids
#5
Swatantra Kumar, Vimal K Maurya, Himanshu R Dandu, Madan Lb Bhatt, Shailendra K Saxena
Among Human immunodeficiency virus (HIV) infected individuals, around two-thirds of patients present with neuroAIDS, where HIV-associated neurocognitive disorders (HAND), and HIV-associated dementia (HAD) are the most prevailing neurological complications. The neuropathology of neuroAIDS can be characterized by the presence of HIV infected macrophages and microglia in the brain, with the formation of multinucleated giant cells. Global predominant subtypes of HIV-1 clade B and C infections influence the differential effect of immune and neuronal dysfunctions, leading to clade-specific clinical variation in neuroAIDS patient cohorts...
May 8, 2018: Biomolecular Concepts
https://www.readbyqxmd.com/read/29732313/effect-of-herbal-extracts-on-bone-regeneration-in-a-rat-calvaria-defect-model-and-screening-system
#6
Dong-Hwan Lee, Il-Kyu Kim, Hyun-Young Cho, Ji-Hoon Seo, Jun-Min Jang, Jin Kim
Objectives: The aim of this study was to evaluate the effects of herbal extracts on bone regeneration. Two known samples were screened. Materials and Methods: We previously established a rat calvaria defect model using a combination of collagen scaffold and herbal extracts. An 8 mm diameter trephine bur with a low-speed dental hand piece was used to create a circular calvaria defect. The experimental group was divided into 4 classifications: control, collagen matrix, Danshen with collagen, and Ge Gan with collagen...
April 2018: Journal of the Korean Association of Oral and Maxillofacial Surgeons
https://www.readbyqxmd.com/read/29709495/morphological-changes-induced-by-intraprostatic-psa-based-vaccine-in-prostate-cancer-biopsies-phase-i-clinical-trial
#7
Maria J Merino, A Peter, Vanessa Moreno, Sara Gil, Jeffrey Schlom, James L Gulley
Immunotherapy is a novel treatment for many tumors including prostate cancer. Little is known about the histological changes in prostate biopsies caused by the prostatic-specific antigen (PSA)-based vaccine. This study evaluated the histopathological effects in prostate biopsies of recombinant fowlpox (rF) virus-based vaccine engineered to present the PSA and three costimulatory molecules (collectively labeled as PSA-TRICOM). This vaccine has shown that it can break tolerance of the PSA, and its administration directly into a tumor enables the affected tumor cells to act as antigen-presenting cells activating new T-cells, and broadening the immune response to recognize and kill tumor...
April 27, 2018: Human Pathology
https://www.readbyqxmd.com/read/29701572/detection-and-phylogenetic-characterization-of-porcine-circovirus-2-from-pigs-in-mozambique
#8
Cláudio J Laisse, Carine K Souza, Paula R Pereira, Cíntia De Lorenzo, Matheus V Bianchi, Lourenço P Mapaco, Saulo P Pavarini, Cláudio W Canal, David Driemeier
Porcine circovirus-associated diseases (PCVADs), caused by porcine circovirus 2 (PCV-2), have a significant economic impact on the swine industry worldwide. In Africa, there is little information, to date, regarding the occurrence of PCV-2, and it has not been reported in Mozambique's swine population. We randomly collected mesenteric lymph nodes ( n = 111) from slaughtered pigs from 9 districts in southern Mozambique. PCV-2 DNA was detected in 54% (62 of 111) of the samples and 78% (23 of 31) of the farms...
May 2018: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/29697422/keratoacanthomatous-changes-unifying-the-histologic-spectrum-of-actinic-granuloma
#9
Jennifer N Harb, Jessica E Kalen, Sylvia Hsu, Abdul Hafeez Diwan, Antoanella Calame, Kiran Motaparthi
Actinic granuloma (AG) manifests as annular plaques on sun-damaged skin. There remains no universal consensus on the nosology, etiology, or clinicopathologic criteria of AG as a distinct entity. Broadly, AG is characterized by granulomatous inflammation, multinucleated giant cells, elastophagocytosis, and the absence of mucin and necrobiosis. It is not uncommon, however, to encounter overlapping histological features of other granulomas, such as granuloma annulare and necrobiosis lipoidica, confounding the diagnosis of this controversial entity...
April 24, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29673796/cigarette-smoke-extract-interferes-with-placenta-macrophage-functions-a-new-mechanism-to-compromise-placenta-functions
#10
Rym Belhareth, Soraya Mezouar, Amira Ben Amara, Céline Chartier, Eya Ben Azzouz, Eric Chabrière, Mohamed Amri, Jean-Louis Mege
The success of pregnancy depends on the maternal immune system's ability to promote tolerance and host defense. This equilibrium is compromised in inflammatory and infectious impairment of placenta. Smoking during pregnancy exposes the fetus to severe complications which might result from an alteration in placenta macrophages (pMφ) functions. In this study, we assessed the effect of cigarette smoke extract (CSE) on the functions of third trimester pMφs.CSE inhibited particles uptake and the formation of multinucleated giant cells, a recently reported property of pMφs based on their ability to fuse in vitro...
April 16, 2018: Reproductive Toxicology
https://www.readbyqxmd.com/read/29669483/study-of-lung-toxicity-in-rats-exposed-to-silica-powder-with-different-hard-metal-constituents
#11
Zhansai Zhang, Yanfang Zhao, Gang Chen, Ruoming Li, Jun Yang, Daoyuan Sun
The objective of this study was to assess the lung toxicity induced by the inhalation of different hard metal constituents and silica powder and screen for potential toxicity biomarkers. Rats were randomly divided into saline, cobalt, tungsten carbide, silica, and hard metal (HM) groups and were administered a single 10-mg dose of the respective treatments. After 8 weeks, the lung tissue structure in the HM group was deformed, numerous nucleated giant and epithelial-like cells appeared in the stroma, and the computed tomography scanning images appeared abnormal...
January 1, 2018: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/29662021/roles-of-polyploid-multinucleated-giant-cancer-cells-in-metastasis-and-disease-relapse-following-anticancer-treatment
#12
Razmik Mirzayans, Bonnie Andrais, David Murray
Tumors and tumor-derived cell lines contain polyploid giant cells with significantly elevated genomic content, often with multiple nuclei. The frequency of giant cells can increase markedly following anticancer treatment. Although giant cells enter a dormant phase and therefore do not form macroscopic colonies (aggregates of ≥50 cells) in the conventional in vitro colony formation assay, they remain viable and metabolically active. The purpose of this commentary is to underscore the potential importance of polyploid/multinucleated giant cells in metastasis and cancer recurrence following exposure to anticancer agents...
April 15, 2018: Cancers
https://www.readbyqxmd.com/read/29658451/-clinical-and-genetic-analysis-of-a-pediatric-patient-with-sodium-taurocholate-cotransporting-polypeptide-deficiency
#13
Hua Li, Jian-Wu Qiu, Gui-Zhi Lin, Mei Deng, Wei-Xia Lin, Ying Cheng, Yuan-Zong Song
Sodium taurocholate cotransporting polypeptide (NTCP) deficiency is an inborn error of bile acid metabolism caused by mutations of SLC10A1 gene. This paper reports the clinical and genetic features of a patient with this disease. A 3.3-month-old male infant was referred to the hospital with the complaint of jaundiced skin and sclera over 3 months. Physical examination revealed moderate jaundice of the skin and sclera. The liver was palpable 3.5 cm below the right subcostal margin with a medium texture. Serum biochemistry analysis revealed markedly elevated bilirubin (predominantly direct bilirubin) and total bile acids (TBA), as well as decreased 25-OH-VitD level...
April 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29650028/a-rare-presentation-of-pulmonary-sarcoidosis-as-a-solitary-lung-mass-a-case-report
#14
Dylan W Kelleher, Madeleine Yaggi, Robert Homer, Erica L Herzog, Changwan Ryu
BACKGROUND: Sarcoidosis is a multisystem, chronic granulomatous disease of unknown etiology that predominantly affects the lungs. Pulmonary sarcoidosis classically presents with constitutional symptoms and computed tomographic scan findings of bilateral, symmetric micronodules in a peribronchovascular distribution with upper and middle lung zone predominance accompanied by bilateral, symmetric hilar lymphadenopathy. A solitary lung mass is a rare finding for pulmonary sarcoidosis, and with its associated constitutional symptoms, it strongly mimics a malignancy...
April 13, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29629646/fibroblastic-osteosarcoma-with-epithelioid-and-squamous-differentiation-in-a-dog
#15
Tiffany L Jenkins, Dalen Agnew, Daniel R Rissi
A fibroblastic osteosarcoma with epithelioid and squamous differentiation in the distal femur of a 9-y-old spayed female Greyhound dog is described. Grossly, the tumor consisted of a pale-white, firm-to-hard mass that replaced the medullary and cortical areas of the distal end of the right femur. Histologically, the mass was composed predominantly of spindle cells admixed with areas of mineralized and non-mineralized osteoid matrix that were surrounded by stellate osteoblasts and scattered multinucleate giant cells, consistent with the diagnosis of a fibroblastic osteosarcoma...
April 1, 2018: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/29609578/the-identification-of-h3f3a-mutation-in-giant-cell-tumour-of-the-clivus-and-the-histological-diagnostic-algorithm-of-other-clival-lesions-permit-the-differential-diagnosis-in-this-location
#16
Federica Scotto di Carlo, Giuseppina Divisato, Maurizio Iacoangeli, Teresa Esposito, Fernando Gianfrancesco
BACKGROUND: Giant Cell Tumour of Bone (GCT) is a locally aggressive primary bone tumour that usually occurs at the epiphyses of the long bones of the appendicular skeleton with a tendency to recurrence. Recurrent somatic H3F3A mutations have been described in 92% of GCT cases. GCTs involving the Clivus are extremely rare lesions and less than 15 cases are described in the literature. They represent a surgery challenge and are easily misdiagnosed. Our aim was to reveal if the genetic bases underlying Clival GCTs were the same of GCTs of long bones to improve the diagnosis and treatment...
April 2, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29608169/fabricating-optical-quality-glass-surfaces-to-study-macrophage-fusion
#17
James J Faust, Wayne Christenson, Kyle Doudrick, John Heddleston, Teng-Leong Chew, Marko Lampe, Arnat Balabiyev, Robert Ros, Tatiana P Ugarova
Visualizing the formation of multinucleated giant cells (MGCs) from living specimens has been challenging due to the fact that most live imaging techniques require propagation of light through glass, but on glass macrophage fusion is a rare event. This protocol presents the fabrication of several optical-quality glass surfaces where adsorption of compounds containing long-chain hydrocarbons transforms glass into a fusogenic surface. First, preparation of clean glass surfaces as starting material for surface modification is described...
March 14, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29603323/brown-tumor-of-the-jaws-as-a-manifestation-of-tertiary-hyperparathyroidism-a-literature-review-and-case-report
#18
Bethina Dos Santos, Valesca Sander Koth, Maria Antonia Figueiredo, Fernanda Gonçalves Salum, Karen Cherubini
Brown tumor of the jaws is a manifestation of hyperparathyroidism consisting of osteolytic lesions that show proliferation of multinucleated giant cells in the maxilla and/or mandible. Differential diagnosis of these lesions from local central giant-cell granuloma is mandatory for the correct treatment of the patient. Radiographic and histopathological exams of the jaw lesion are not sufficient to determine the diagnosis, which requires laboratory tests including serum levels of calcium, alkaline phosphatase, parathyroid hormone (PTH) and phosphate, and radiographic examination of other bones as well, such as hand-wrist, pelvis, and femur...
March 30, 2018: Special Care in Dentistry
https://www.readbyqxmd.com/read/29600575/matrix-metalloproteinase-9-expression-of-gctsc-in-peripheral-tissue-and-central-tissue-of-gctb
#19
Liang Chen, Ji Zhang, Yifeng He, Xiao-Yi Ding
Giant cell tumor stromal cell (GCTSC) is the tumor cell of giant cell tumor of bone (GCTB). The biomarkers characterization of GCTSC is critical for the selection of GCTB targeting drugs. We believe the main functions of GCTSC in different part of tumor should be different for different environment. Then the biological behavior and molecular biomarkers of GCTSC should be different as well. Based on this idea, we focused on GCTSC which located in central tissue, peripheral tissue and took MMP-9 as the breakthrough point to carry out research...
March 30, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29599321/induction-of-mitotic-catastrophe-in-human-cervical-cancer-cells-after-administration-of-aloe-emodin
#20
Wojciech Trybus, Teodora Król, Ewa Trybus, Anna Stachurska, Anna Kopacz-Bednarska, Grzegorz Król
BACKGROUND: Aloe-emodin is an anthraquinone with potential pharmacological properties, including numerous antitumor properties. The purpose of the study was to determine whether aloe-emodin induces mitotic death in cervical cancer cells. MATERIALS AND METHODS: Analysis of morphological changes as surrogate mitotic death indicators in HeLa cells was carried out using optical, fluorescence and electron microscopy. Viability was determined by 3-(4,5-dimethylthiazol-2-yl)-2-5-diphenyltetrazolium bromide reduction assay...
April 2018: Anticancer Research
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