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https://www.readbyqxmd.com/read/28642027/-monitoring-devices-and-their-alarms-incident-reports-suggest-problems-with-device-knowledge
#1
Kathrin Lange, Miriam Nowak, Claudia Neudörfl, Wolfgang Lauer
Missing or false device alarms pose a risk in clinical practice. Publications from the United States suggest that alarm errors are not only caused by technical issues but to a considerable degree result from user-device interaction problems. To safely operate a medical device, users have to thoroughly understand both device behavior and device functioning. They also need to foresee the exact consequences of their interactions with the device. This can be challenging, especially if a device has multiple functions, is applied in various use contexts or networked with other devices - as is often the case with patient monitors...
June 19, 2017: Zeitschrift Für Evidenz, Fortbildung und Qualität Im Gesundheitswesen
https://www.readbyqxmd.com/read/28634103/undetectable-mannose-binding-lectin-and-corticosteroids-increase-serious-infection-risk-in-rheumatoid-arthritis
#2
Graeme J Carroll, Krista Makin, Maxine Garnsey, Max Bulsara, Bronwyn V Carroll, Shona M Curtin, Erin M Allan, Andrew McLean-Tooke, Christine Bundell, Monica L Kemp, Pooja Deshpande, Dana Ihdayhid, Sophie Coleman, Tracie Easter, James Triplett, Timothy Disteldorf, C Helen Marsden, Michaela Lucas
BACKGROUND: Infection is the leading cause of death in rheumatoid arthritis (RA). Corticosteroid (CS) use is a known and important risk factor for serious infections (SIs). Mannose binding lectin (MBL) is a genetically determined component of the innate immune system implicated in neonatal infections. OBJECTIVE: Our aim was to determine whether MBL deficiency is a risk factor for SIs in RA and to compare it with CS use and also synthetic and biologic disease-modifying antirheumatic drug (DMARD) therapy...
June 17, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28631397/the-effects-and-toxicity-of-cathinones-from-the-users-perspectives-a-qualitative-study
#3
Sulaf Assi, Nargilya Gulyamova, Paul Kneller, David Osselton
OBJECTIVE: The objective of this study is to explore the users' perspectives regarding the effects and toxicity of cathinones. METHODS: A systematic search of Internet discussion forums yielded 303 threads relevant to the research objectives. The threads were analysed by conventional content analysis where concepts were developed from codes and themes. RESULTS: The study identified 3 main themes in relation to cathinone use, effects, and toxicity...
June 20, 2017: Human Psychopharmacology
https://www.readbyqxmd.com/read/28623899/renin-angiotensin-system-blockers-and-residual-kidney-function-loss-in-patients-initiating-peritoneal-dialysis-an-observational-cohort-study
#4
Jenny I Shen, Anjali B Saxena, Sitaram Vangala, Satvinder K Dhaliwal, Wolfgang C Winkelmayer
BACKGROUND: Although angiotensin-converting enzyme inhibitors (ACEI) and angiotensin-II receptor blockers (ARB) have been shown to preserve residual kidney function in a select group of Asian patients undergoing continuous ambulatory peritoneal dialysis (PD) in two small randomized clinical trials, the effectiveness of these drugs has yet to be demonstrated in a more diverse population of patients with multiple comorbid conditions. We investigated the association between ACEI/ARB use and development of recorded anuria in a cohort of patients initiating PD in the U...
June 17, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28622731/navigating-tissue-chips-from-development-to-dissemination-a-pharmaceutical-industry-perspective
#5
Lorna Ewart, Kristin Fabre, Ananthsrinivas Chakilam, Yvonne Dragan, David B Duignan, Jeetu Eswaraka, Jinping Gan, Peggy Guzzie-Peck, Monicah Otieno, Claire G Jeong, Douglas A Keller, Sonia M de Morais, Jonathan A Phillips, William Proctor, Radhakrishna Sura, Terry Van Vleet, David Watson, Yvonne Will, Danilo Tagle, Brian Berridge
Tissue chips are poised to deliver a paradigm shift in drug discovery. By emulating human physiology, these chips have the potential to increase the predictive power of preclinical modeling, which in turn will move the pharmaceutical industry closer to its aspiration of clinically relevant and ultimately animal-free drug discovery. Despite the tremendous science and innovation invested in these tissue chips, significant challenges remain to be addressed to enable their routine adoption into the industrial laboratory...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28614161/multiple-cerebral-infarcts-in-a-young-patient-associated-with-marijuana-use
#6
Leila Costa Volpon, Camila Lacerda Muniz de Melo Sousa, Silvia Keiko Kavaguti Moreira, Sara Reis Teixeira, Ana Paula de Carvalho Panzeri Carlotti
: Cerebrovascular events associated with marijuana use have been reported previously. This association is plausible, but not well-established yet. A 14-year-old girl, long-term heavy cannabis user, presented with generalized tonic-clonic seizures and decreased level of consciousness a few hours after smoking cannabis. Brain magnetic resonance imaging showed multiple areas of acute, subacute and chronic ischemic lesions in the left frontal lobe, basal ganglia, and corpus callosum. History of other illicit drug use and other known causes of stroke were ruled out...
June 13, 2017: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/28605385/time-dependent-increase-in-the-network-response-to-the-stimulation-of-neuronal-cell-cultures-on-micro-electrode-arrays
#7
Monica L Gertz, Zachary Baker, Sharon Jose, Nathalia Peixoto
Micro-electrode arrays (MEAs) can be used to investigate drug toxicity, design paradigms for next-generation personalized medicine, and study network dynamics in neuronal cultures. In contrast with more traditional methods, such as patch-clamping, which can only record activity from a single cell, MEAs can record simultaneously from multiple sites in a network, without requiring the arduous task of placing each electrode individually. Moreover, numerous control and stimulation configurations can be easily applied within the same experimental setup, allowing for a broad range of dynamics to be explored...
May 29, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28601512/epidemiology-of-fentanyl-involved-drug-overdose-deaths-a-geospatial-retrospective-study-in-rhode-island-usa
#8
Brandon D L Marshall, Maxwell S Krieger, Jesse L Yedinak, Patricia Ogera, Priya Banerjee, Nicole E Alexander-Scott, Josiah D Rich, Traci C Green
BACKGROUND: We conducted an epidemiological investigation of fentanyl and non-fentanyl overdose deaths in Rhode Island to inform overdose prevention efforts. METHODS: All drug overdose deaths occurring in Rhode Island between January 1, 2014 and September 30, 2016 were included. Overdose circumstances and decedent characteristics were ascertained from medical examiner files. Toxicological reports provided quantification of fentanyl and metabolites. ArcGIS was used to map exact overdose locations...
June 7, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28597537/the-challenge-of-complex-drug-use-associated-use-of-codeine-containing-medicines-and-new-psychoactive-substances-in-a-european-cross-sectional-online-population
#9
Andreas Kimergård, Michelle Foley, Zoe Davey, Elle Wadsworth, Colin Drummond, Paolo Deluca
OBJECTIVE: Misuse of codeine-containing medicines in combination with new psychoactive substances (NPS) is inadequately described. This study characterises codeine consumption amongst NPS users and non-NPS users to provide warning of health issues. METHODS: Online survey conducted between July 2015 and March 2016. RESULTS: Out of 340 respondents, residing in a country in Europe and using codeine recently, 63.8% were female. Mean age: 34.9 years (SD = 12...
June 9, 2017: Human Psychopharmacology
https://www.readbyqxmd.com/read/28578250/increased-in-synthetic-cannabinoids-related-harms-results-from-a-longitudinal-web-based-content-analysis
#10
Francois R Lamy, Raminta Daniulaityte, Ramzi W Nahhas, Monica J Barratt, Alan G Smith, Amit Sheth, Silvia S Martins, Edward W Boyer, Robert G Carlson
BACKGROUND: Synthetic Cannabinoid Receptor Agonists (SCRA), also known as "K2" or "Spice," have drawn considerable attention due to their potential of abuse and harmful consequences. More research is needed to understand user experiences of SCRA-related effects. We use semi-automated information processing techniques through eDrugTrends platform to examine SCRA-related effects and their variations through a longitudinal content analysis of web-forum data. METHOD: English language posts from three drug-focused web-forums were extracted and analyzed between January 1st 2008 and September 30th 2015...
June 1, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28577506/high-enhancer-downer-withdrawal-helper-multifunctional-nonmedical-benzodiazepine-use-among-young-adult-opioid-users-in-new-york-city
#11
Pedro Mateu-Gelabert, Lauren Jessell, Elizabeth Goodbody, Dongah Kim, Krista Gile, Jennifer Teubl, Cassandra Syckes, Kelly Ruggles, Jeffrey Lazar, Sam Friedman, Honoria Guarino
BACKGROUND: Benzodiazepines are a widely prescribed psychoactive drug; in the U.S., both medical and nonmedical use of benzodiazepines has increased markedly in the past 15 years. Long-term use can lead to tolerance and dependence, and abrupt withdrawal can cause seizures or other life-threatening symptoms. Benzodiazepines are often used nonmedically in conjunction with other drugs, and with opioids in particular-a combination that can increase the risk for fatal and non-fatal overdose...
May 31, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28574740/people-who-inject-drugs-and-have-mood-disorders-a-brief-assessment-of-health-risk-behaviors
#12
Stacey Carroll Williams, Melissa Ann Davey-Rothwell, Karin E Tobin, Carl Latkin
BACKGROUND: People who inject drugs have a greater risk of infectious disease and mortality than other substance abusers and nondrug users. Variation in risk behavior among people who inject drugs is likely associated with comorbid mental health disorders. OBJECTIVES: Examine the association between a history of mood disorder and recent risk behavior among people who inject drugs. METHODS: With baseline data from a behavioral HIV prevention clinical trial in a population of people who inject drugs, we used logistic regression models to compare the risk behaviors of people who report a past diagnosis of bipolar disorder (n = 113) or depression (n = 237) to a comparison group with no history of diagnosed mental illness (n = 446)...
June 2, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28567550/hiv-prevalence-knowledge-attitudes-and-practices-among-polydrug-users-in-brazil-a-biological-survey-using-respondent-driven-sampling
#13
Cremildo João Baptista, Inês Dourado, Tarcísio Matos de Andrade, Sandra Brignol, Neilane Bertoni, Francisco Inácio Bastos
Brazil has a concentrated HIV epidemic among key populations. In 2009, the Ministry of Health conducted a survey in 10 Brazilian cities aiming to estimate HIV prevalence, knowledge, and associated risk behaviors of polysubstance users (PSU). Using Respondent Driven Sampling (RDS), 3449 PSU were recruited, answered an Audio-Computer Self Assisted Interview (ACASI) and were tested for HIV and syphilis. Analyses were weighted by individual's social network size generated on RDSAT. Pooled HIV prevalence was 5...
May 31, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28557594/inhalant-use-and-mental-health-problems-in-russian-juvenile-delinquents
#14
Linnea Zachrison, Vladislav Ruchkin, Andrew Stickley, Roman Koposov
BACKGROUND: Inhalant use by children and adolescents has been linked to an increased risk of multiple drug use, mental health problems and antisocial behavior. OBJECTIVES: The purpose of this study was to examine the association between the frequency of inhalant use and psychiatric diagnoses among incarcerated delinquent youths in Russia. METHODS: A total of 370 incarcerated delinquents from a juvenile correction center in Northern Russia were assessed by means of a semi-structured psychiatric interview and by self-reports...
May 30, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28532328/pharmaceutical-entanglements-an-analysis-of-the-multiple-determinants-of-adhd-medication-effects-in-a-chilean-school
#15
Sebastian Rojas Navarro, Scott Vrecko
This article draws upon findings from ethnographic fieldwork conducted in a Chilean school to explore how the effects of globally circulating ADHD medications emerge within the localized contexts of everyday users. An analysis of observations of children on ADHD medications within classroom settings is developed which challenges the assumption, pervasive within biomedical paradigms, that the effects of such medications can be understood as resulting directly from their chemical properties and biological modes of action...
June 2017: International Journal of Qualitative Studies on Health and Well-being
https://www.readbyqxmd.com/read/28529078/hcsgd-an-integrated-database-of-human-cellular-senescence-genes
#16
Qiongye Dong, Hongqing Han, Xuehui Liu, Lei Wei, Wei Zhang, Zhen Zhao, Michael Q Zhang, Xiaowo Wang
Cellular senescence is an irreversible cell cycle arrest program in response to various exogenous and endogenous stimuli like telomere dysfunction and DNA damage. It has been widely accepted as an anti-tumor program and is also found closely related to embryo development, tissue repair, organismal aging and age-related degenerative diseases. In the past decades, numerous efforts have been made to uncover the gene regulatory mechanisms of cellular senescence. There is a strong demand to integrate these data from various resources into one open platform...
May 20, 2017: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/28521744/determination-of-the-sources-and-antimicrobial-resistance-patterns-of-salmonella-isolated-from-the-poultry-industry-in-southern-ethiopia
#17
Reta Duguma Abdi, Fisseha Mengstie, Ashenafi Feyisa Beyi, Takele Beyene, Hika Waktole, Bedasso Mammo, Dinka Ayana, Fufa Abunna
BACKGROUND: Ethiopia set an ambitious masterplan to increase chicken meat and egg production from 2015 to 2020. Poultry breeding, multiplication and distribution centers in the country have received executive order to import, amplify and distribute commercial chickens to end users. The biosecurity and the pathogen fauna of the centers have not been evaluated as to whether the centers could implement the mission effectively without any risk. Thus, the aim of this study was to evaluate the biosecurity practices and the pathogen prevalence, risk factors and their antimicrobial resistance (AMR) using Salmonella as case study...
May 18, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28521146/effect-of-continued-cannabis-use-on-medication-adherence-in-the-first-two-years-following-onset-of-psychosis
#18
Tabea Schoeler, Natalia Petros, Marta Di Forti, Ewa Klamerus, Enrico Foglia, Robin Murray, Sagnik Bhattacharyya
Uncertainty exists whether the use of non-prescription psychoactive substances following onset of a first episode of psychosis (FEP), in particular cannabis use, affects medication adherence. Data from FEP patients (N=233) obtained through prospective assessments measured medication adherence and pattern of cannabis and other substance use in the first two years following onset of psychosis. Multiple logistic regression analyses were employed to compare the different substance use groups with regard to risk of medication non-adherence, while controlling for confounders...
May 10, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28511097/the-relationship-between-social-desirability-bias-and-self-reports-of-health-substance-use-and-social-network-factors-among-urban-substance-users-in-baltimore-maryland
#19
Carl A Latkin, Catie Edwards, Melissa A Davey-Rothwell, Karin E Tobin
BACKGROUND: Social desirability response bias may lead to inaccurate self-reports and erroneous study conclusions. The present study examined the relationship between social desirability response bias and self-reports of mental health, substance use, and social network factors among a community sample of inner-city substance users. METHODS: The study was conducted in a sample of 591 opiate and cocaine users in Baltimore, Maryland from 2009 to 2013. Modified items from the Marlowe-Crowne Social Desirability Scale were included in the survey, which was conducted face-to-face and using Audio Computer Self Administering Interview (ACASI) methods...
May 9, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28493333/treadmill-exercise-attenuates-3-4-methylenedioxymethamphetamine-induced-memory-impairment-through-a-decrease-apoptosis-in-male-rat-hippocampus
#20
Alireza Gharebaghi, Iraj Amiri, Iraj Salehi, Siamak Shahidi, Alireza Komaki, Mehdi Mehdizadeh, Fahimeh Ghasemi Moravej, Sara Soleimani Asl
3,4-methylenedioxymethamphetamine (MDMA) leads to apoptosis in the hippocampus with consequent induction of learning and memory impairment. In this study, we have investigated the effects of treadmill exercise on memory in relation to apoptosis and oxidative stress in the hippocampi of MDMA-treated rats. Male Wistar rats received multiple intraperitoneal (IP) injections of MDMA (10 mg/kg) and exercised for one month on a treadmill (simultaneously or asynchronously with MDMA). We assessed memory function with the Morris water maze (MWM) test...
May 11, 2017: Journal of Neuroscience Research
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