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https://www.readbyqxmd.com/read/27924032/the-antismash-database-a-comprehensive-database-of-microbial-secondary-metabolite-biosynthetic-gene-clusters
#1
Kai Blin, Marnix H Medema, Renzo Kottmann, Sang Yup Lee, Tilmann Weber
Secondary metabolites produced by microorganisms are the main source of bioactive compounds that are in use as antimicrobial and anticancer drugs, fungicides, herbicides and pesticides. In the last decade, the increasing availability of microbial genomes has established genome mining as a very important method for the identification of their biosynthetic gene clusters (BGCs). One of the most popular tools for this task is antiSMASH. However, so far, antiSMASH is limited to de novo computing results for user-submitted genomes and only partially connects these with BGCs from other organisms...
October 24, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27898577/decline-in-herpes-simplex-virus-type-2-among-non-injecting-heroin-and-cocaine-users-in-new-york-city-2005-to-2014-prospects-for-avoiding-a-resurgence-of-human-immunodeficiency-virus
#2
Don C Des Jarlais, Kamyar Arasteh, Jonathan Feelemyer, Courtney McKnight, Susan Tross, David C Perlman, Aimee N C Campbell, Holly Hagan, Hannah L F Cooper
BACKGROUND: Herpes simplex virus type 2 (HSV-2) infection increases both susceptibility to and transmissibility of human immunodeficiency virus (HIV), and HSV-2 and HIV are often strongly associated in HIV epidemics. We assessed trends in HSV-2 prevalence among non-injecting drug users (NIDUs) when HIV prevalence declined from 16% to 8% among NIDUs in New York City. METHODS: Subjects were current non-injecting users of heroin and/or cocaine and who had never injected illicit drugs...
November 28, 2016: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/27845738/drug-dependence-treatment-awareness-among-japanese-female-stimulant-drug-offenders
#3
Shinzo Yatsugi, Koji Fujita, Saori Kashima, Akira Eboshida
Few stimulant drug users receive adequate treatment. This cross-sectional study describes the characteristics of female drug offenders that use stimulants and clarifies the factors related to the awareness of treatment for drug dependencies. We included 80 females imprisoned due to stimulant control law violations from 2012 to 2015. The characteristics of the female prisoners were stratified according to various treatment awareness levels, and associations between each characteristic and treatment awareness were evaluated using logistic regression models...
November 11, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27835662/marijuana-use-is-associated-with-behavioral-approach-and-depressive-symptoms-in-adolescents-and-emerging-adults
#4
Natasha E Wright, Danny Scerpella, Krista M Lisdahl
BACKGROUND: Repeated CB1 binding due to THC results in downregulation of the endocannabinoid system in cortex and limbic regions, perhaps disrupting frontolimbic functioning. This is particularly a concern in young adults who are still undergoing neurodevelopment in frontal and limbic regions. Such disruptions may be linked to increased depressive symptoms, anxiety symptoms, and executive dysfunction, and decreased behavioral approach. OBJECTIVES: Here we examine the influence of young adult marijuana use on anxiety, depressive symptoms, behavioral approach, and executive dysfunction...
2016: PloS One
https://www.readbyqxmd.com/read/27829344/identifying-drug-target-interactions-with-decision-template
#5
Xiao-Ying Yan, Shao-Wu Zhang
During the development process of new drugs, identification of the drug-target interactions wins primary concerns. However, the chemical or biological experiments bear the limitation in coverage as well as the huge cost of both time and money. Based on drug similarity and target similarity, chemogenomic methods can be able to predict potential drug-target interactions (DTIs) on a large scale and have no luxurious need about target structures or ligand entries. Nevertheless, existing methods of drug chemical structure-based similarity and target sequence-based similarity may not reflect the cases that the drugs having variant structures interact with common targets and the targets having dissimilar sequences interact with same drugs...
November 7, 2016: Current Protein & Peptide Science
https://www.readbyqxmd.com/read/27810657/interrelationships-between-marijuana-demand-and-discounting-of-delayed-rewards-convergence-in-behavioral-economic-methods
#6
Elizabeth R Aston, Jane Metrik, Michael Amlung, Christopher W Kahler, James MacKillop
BACKGROUND: Distinct behavioral economic domains, including high perceived drug value (demand) and delay discounting (DD), have been implicated in the initiation of drug use and the progression to dependence. However, it is unclear whether frequent marijuana users conform to a "reinforcer pathology" addiction model wherein marijuana demand and DD jointly increase risk for problematic marijuana use and cannabis dependence (CD). METHODS: Participants (n=88, 34% female, 14% cannabis dependent) completed a marijuana purchase task at baseline...
December 1, 2016: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/27802862/isolated-pulmonary-valve-endocarditis-masquerading-as-community-acquired-pneumonia
#7
Salik Nazir, Saroj Lohani, Niranjan Tachamo, Anam Siddiqui, Nitin Patel
Isolated pulmonary valve endocarditis in intravenous drug users is a rarely reported phenomenon. We present the case of a 25-year-old male with history of intravenous drug use who presented with respiratory symptoms after failing outpatient treatment for community-acquired pneumonia. Further investigations identified multiple lung lesions with early cavitation, concerning for septic pulmonary embolism on computerized tomography scan, positive blood cultures with methicillin-susceptible staphylococcus aureus, and isolated vegetation of the pulmonic valve on transthoracic echocardiography...
2016: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/27785449/hepatocellular-carcinoma-a-review
#8
REVIEW
Julius Balogh, David Victor, Emad H Asham, Sherilyn Gordon Burroughs, Maha Boktour, Ashish Saharia, Xian Li, R Mark Ghobrial, Howard P Monsour
Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and is a leading cause of cancer-related death worldwide. In the United States, HCC is the ninth leading cause of cancer deaths. Despite advances in prevention techniques, screening, and new technologies in both diagnosis and treatment, incidence and mortality continue to rise. Cirrhosis remains the most important risk factor for the development of HCC regardless of etiology. Hepatitis B and C are independent risk factors for the development of cirrhosis...
2016: Journal of Hepatocellular Carcinoma
https://www.readbyqxmd.com/read/27776135/top-down-network-effective-connectivity-in-abstinent-substance-dependent-individuals
#9
Michael F Regner, Naomi Saenz, Keeran Maharajh, Dorothy J Yamamoto, Brianne Mohl, Korey Wylie, Jason Tregellas, Jody Tanabe
OBJECTIVE: We hypothesized that compared to healthy controls, long-term abstinent substance dependent individuals (SDI) will differ in their effective connectivity between large-scale brain networks and demonstrate increased directional information from executive control to interoception-, reward-, and habit-related networks. In addition, using graph theory to compare network efficiencies we predicted decreased small-worldness in SDI compared to controls. METHODS: 50 SDI and 50 controls of similar sex and age completed psychological surveys and resting state fMRI...
2016: PloS One
https://www.readbyqxmd.com/read/27768992/factors-associated-with-syphilis-seroreactivity-among-polydrug-users-in-northeast-brazil-a-cross-sectional-study-using-respondent-driven-sampling
#10
Cremildo João Baptista, Ines Dourado, Sandra Brignol, Tarcísio de Matos Andrade, Francisco Inácio Bastos
BACKGROUND: The burden of sexually transmitted infections (STIs), such as syphilis, is higher in low-income countries, with serious consequences and profound impact on sexual and reproductive health and human immunodeficiency virus (HIV) spread. Syphilis prevalence tend to be higher among people who misuse drugs than in the general population. OBJECTIVE: To assess syphilis and associated factors among polydrug users (PDU) in the city of Salvador, Northeast Brazil...
October 18, 2016: International Journal on Drug Policy
https://www.readbyqxmd.com/read/27767235/demographic-trends-among-older-cannabis-users-in-the-united-states-2006-2013
#11
Benjamin H Han, Scott Sherman, Pia M Mauro, Silvia S Martins, James Rotenberg, Joseph J Palamar
BACKGROUND AND AIMS: The ageing United States (US) population is providing an unprecedented population of older adults who use recreational drugs. We aimed to estimate the trends in the prevalence of past-year use of cannabis, describe the patterns and attitudes, and determine correlates of cannabis use by adults age 50 and older. DESIGN: Secondary analysis of the National Survey on Drug Use and Health survey from 2006 to 2013, a cross-sectional survey given to a nationally representative probability sample of populations living in US households...
October 21, 2016: Addiction
https://www.readbyqxmd.com/read/27761744/predominance-of-crf63_02a1-and-multiple-patterns-of-unique-recombinant-forms-of-crf63_a1-among-individuals-with-newly-diagnosed-hiv-1-infection-in-kemerovo-oblast-russia
#12
Natalya M Gashnikova, Darya P Zyryanova, Ekaterina M Astakhova, Vladimir V Ivlev, Maria P Gashnikova, Natalya V Moskaleva, Sergey S Aikin, Tatyana N Bulatova, Sergey V Pustylnikov, Evgeny F Bocharov, Aleksey V Totmenin
Kemerovo Oblast (KO) has had the highest rate of HIV spread in Russia since 2011. The aim of this work was to study the genetic variation of HIV-1 in Kemerovo Oblast. Blood was sampled from a total of 91 HIV-positive antiretroviral-therapy-naïve individuals in 2013 (38) and 2015 (53). HIV-1 subtypes, pol gene drug resistance mutations, and viral tropism were analyzed. In 2013-2015, the prevalence of HIV-1 subtype A decreased in KO from 60.5 to 7.5 %. The samples collected in 2015 from the patients with newly diagnosed HIV demonstrate the current dominance of HIV-1 CRF63_02A1 (71...
October 19, 2016: Archives of Virology
https://www.readbyqxmd.com/read/27758707/new-psychoactive-substances-3-methoxyphencyclidine-3-meo-pcp-and-3-methoxyrolicyclidine-3-meo-pcpy-metabolic-fate-elucidated-with-rat-urine-and-human-liver-preparations-and-their-detectability-in-urine-by-gc-ms-lc-high-resolution-msn-and-lc-high-resolution
#13
Julian A Michely, Sascha K Manier, Achim T Caspar, Simon D Brandt, Jason Wallach, Hans H Maurer
3-Methoxyphencyclidine (3-MeO-PCP) and 3-methoxyrolicyclidine (3-MeO-PCPy) are two new psychoactive substances (NPS). The aims of the present study were the elucidation of their metabolic fate in rat and pooled human liver microsomes (pHLM), the identification of the cytochrome P450 (CYP) isoenzymes involved, and the detectability using standard urine screening approaches (SUSA) after intake of common users' doses using gas chromatography-mass spectrometry (GC-MS), liquid chromatography-multi-stage mass spectrometry (LC-MSn), and liquid chromatography-high-resolution tandem mass spectrometry (LC-HR-MS/MS)...
October 18, 2016: Current Neuropharmacology
https://www.readbyqxmd.com/read/27756381/molecular-epidemiology-of-hepatitis-c-infections-in-ningxia-china-genotype-phylogeny-and-mutation-analysis
#14
Zhonglan Wu, Lijia Cui, Weiming Zhao, Dongzhi Yang, Hui Chen, Ruiqing Wang, Xuemin Wang, Linqi Zhang, Tianhua He
BACKGROUND: Current prevalence and genotype distribution of hepatitis C virus (HCV) infection remain unknown in Ningxia, northwest China. METHODS: From June to December 2013, 13,022 individuals were screened in Ningxia HIV/AIDS Sentinel Surveillance System, with their demographic features collected and serum samples tested for HCV antibody. Sero-positive drug users were further subjected to sequencing of NS5B and Core regions of HCV. RESULTS: The anti-HCV prevalence was 0...
October 18, 2016: Virology Journal
https://www.readbyqxmd.com/read/27754161/pl-03-2-remote-blood-pressure-monitoring-in-hypertension-care-practice-of-hypertension-by-teletransmission-of-home-blood-pressure
#15
Yutaka Imai
It has been confirmed that clinical significance of home blood pressure measurements (HBPM) is higher than clinic BP measurements and ambulatory BP monitoring. However, several drawbacks of HBPM have also been mentioned, e.g. selection and reporting biases, difficulties of calculation of multiple measurements, difficulties of onsite judgement of numerous recordings, etc. Recent devices for HBPM incorporate memory function. This function can overcome such drawbacks of HBPM. These memorized data can transmit, storage, retrieve, be arithmetic and control, be judged based on algorithm and be got feedback...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27746730/using-pharmacogenomic-databases-for-discovering-patient-target-genes-and-small-molecule-candidates-to-cancer-therapy
#16
José E Belizário, Beatriz A Sangiuliano, Marcela Perez-Sosa, Jennifer M Neyra, Dayson F Moreira
With multiple omics strategies being applied to several cancer genomics projects, researchers have the opportunity to develop a rational planning of targeted cancer therapy. The investigation of such numerous and diverse pharmacogenomic datasets is a complex task. It requires biological knowledge and skills on a set of tools to accurately predict signaling network and clinical outcomes. Herein, we describe Web-based in silico approaches user friendly for exploring integrative studies on cancer biology and pharmacogenomics...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27738991/potential-gray-matter-unpruned-in-adolescents-and-young-adults-dependent-on-dextromethorphan-containing-cough-syrups-evidence-from-cortical-and-subcortical-study
#17
Ying-Wei Qiu, Xiao-Fei Lv, Gui-Hua Jiang, Huan-Huan Su, Xiao-Fen Ma, Jun-Zhang Tian, Fu-Zhen Zhuo
Adolescence is a unique period in neurodevelopment. Dextromethorphan (DXM)-containing cough syrups are new addictive drugs used by adolescents and young adults. The effects of chronic DXM abuse on neurodevelopment in adolescents and young adults are still unknown. The aim of this study was to investigate the differences in cortical thickness and subcortical gray matter volumes between DXM-dependent adolescents and young adults and healthy controls, and to explore relationships between alternations in cortical thickness/subcortical volume and DXM duration, initial age of DXM use, as well as impulsive behavior in DXM-dependent adolescents and young adults...
October 13, 2016: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/27736678/white-matter-disruptions-in-male-cocaine-polysubstance-users-associations-with-severity-of-drug-use-and-duration-of-abstinence
#18
Dana van Son, Reinout W Wiers, Andrés Catena, Miguel Perez-Garcia, Antonio Verdejo-García
BACKGROUND: Cocaine dependence has been associated with alterations in the brain's white matter integrity, yet relevant questions remain about what alterations are linked to cocaine use and/or polysubstance use, and whether they are amenable to abstinence. METHODS: This study applied a single measurement session of diffusion tensor imaging (DTI) to examine white matter structure in male cocaine polysubstance users (n=37) versus male healthy controls (n=38), along with correlations between DTI measures and patterns of polysubstance use and duration of abstinence...
October 6, 2016: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/27733502/szgr-2-0-a-one-stop-shop-of-schizophrenia-candidate-genes
#19
Peilin Jia, Guangchun Han, Junfei Zhao, Pinyi Lu, Zhongming Zhao
SZGR 2.0 is a comprehensive resource of candidate variants and genes for schizophrenia, covering genetic, epigenetic, transcriptomic, translational and many other types of evidence. By systematic review and curation of multiple lines of evidence, we included almost all variants and genes that have ever been reported to be associated with schizophrenia. In particular, we collected ∼4200 common variants reported in genome-wide association studies, ∼1000 de novo mutations discovered by large-scale sequencing of family samples, 215 genes spanning rare and replication copy number variations, 99 genes overlapping with linkage regions, 240 differentially expressed genes, 4651 differentially methylated genes and 49 genes as antipsychotic drug targets...
October 12, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27733010/beta-blockers-improve-survival-outcomes-in-patients-with-multiple-myeloma-a-retrospective-evaluation
#20
Yi L Hwa, Qian Shi, Shaji K Kumar, Martha Q Lacy, Morie A Gertz, Prashant Kapoor, Francis K Buadi, Nelson Leung, David Dingli, Ronald S Go, Suzanne R Hayman, Wilson I Gonsalves, Stephen Russell, John A Lust, Yi Lin, S Vincent Rajkumar, Angela Dispenzieri
A preclinical study demonstrated anti-proliferative and apoptotic effect of propranolol on multiple myeloma (MM) cell. Clinical studies suggested that beta-blocker (BB) might impact the prognosis of breast, prostate, colorectal, ovarian, lung, and skin cancer. This retrospective study evaluated the effect of BB in MM disease-specific survival (DSS) and overall survival (OS). Among 1,971 newly diagnosed MM patients seen at Mayo Clinic between 1995 and 2010, usage of BB and other cardiac (or antihypertensive) medications were abstracted...
October 12, 2016: American Journal of Hematology
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