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Spinal cord computational model

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https://www.readbyqxmd.com/read/28616040/stem-cell-transplantation-for-spinal-cord-injury-a-meta-analysis-of-treatment-effectiveness-and-safety
#1
Xiao Fan, Jin-Zhao Wang, Xiao-Min Lin, Li Zhang
OBJECTIVE: The aim of this study was to evaluate the effectiveness and safety of stem cell transplantation for spinal cord injury (SCI). DATA SOURCES: PubMed, EMBASE, Cochrane, China National Knowledge Infrastructure, China Science and Technology Journal, Wanfang, and SinoMed databases were systematically searched by computer to select clinical randomized controlled trials using stem cell transplantation to treat SCI, published between each database initiation and July 2016...
May 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28586096/spinal-cord-multi-parametric-magnetic-resonance-imaging-for-survival-prediction-in-amyotrophic-lateral-sclerosis
#2
G Querin, M M El Mendili, T Lenglet, S Delphine, V Marchand-Pauvert, H Benali, P-F Pradat
BACKGROUND AND PURPOSE: Assessing survival is a critical issue in patients with amyotrophic lateral sclerosis (ALS). Neuroimaging seems to be promising in the assessment of disease severity and several studies also suggest a strong relationship between spinal cord (SC) atrophy described by magnetic resonance imaging (MRI) and disease progression. The aim of the study was to determine the predictive added value of multimodal SC MRI on survival. METHODS: Forty-nine ALS patients were recruited and clinical data were collected...
June 6, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28501711/protection-of-cortex-by-overlying-meninges-tissue-during-dynamic-indentation-of-the-adolescent-brain
#3
David B MacManus, Baptiste Pierrat, Jeremiah G Murphy, Michael D Gilchrist
Traumatic brain injury (TBI) has become a recent focus of biomedical research with a growing international effort targeting material characterization of brain tissue and simulations of trauma using computer models of the head and brain to try to elucidate the mechanisms and pathogenesis of TBI. The meninges, a collagenous protective tri-layer which encloses the entire brain and spinal cord has been largely overlooked in these material characterization studies. This has resulted in a lack of accurate constitutive data for the cranial meninges, particularly under dynamic conditions such as those experienced during head impacts...
May 10, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28494130/visualization-of-stereoscopic-anatomic-models-of-the-paranasal-sinuses-and-cervical-vertebrae-from-the-surgical-and-procedural-perspective
#4
Jian Chen, Andrew D Smith, Majid A Khan, Allan R Sinning, Marianne L Conway, Dongmei Cui
Recent improvements in three-dimensional (3D) virtual modeling software allows anatomists to generate high-resolution, visually appealing, colored, anatomical 3D models from computed tomography (CT) images. In this study, high-resolution CT images of a cadaver were used to develop clinically relevant anatomic models including facial skull, nasal cavity, septum, turbinates, paranasal sinuses, optic nerve, pituitary gland, carotid artery, cervical vertebrae, atlanto-axial joint, cervical spinal cord, cervical nerve root, and vertebral artery that can be used to teach clinical trainees (students, residents, and fellows) approaches for trans-sphenoidal pituitary surgery and cervical spine injection procedure...
May 11, 2017: Anatomical Sciences Education
https://www.readbyqxmd.com/read/28489540/nonlinear-frequency-domain-analysis-of-the-transformation-of-cortical-inputs-by-a-motoneuron-pool-muscle-complex
#5
Renato Watanabe, Andre Kohn
Corticomotor coherence in the beta and/or gamma bands has been described in different motor tasks but the role of descending brain oscillations on force control has been elusive. Large-scale computational models of a motoneuron pool and the muscle it innervates have been used as tools to advance the knowledge of how neural elements may influence force control. Here we present a frequency domain analysis of a NARX model fitted to a large-scale neuromuscular model by means of generalized frequency response functions (GFRF)...
May 4, 2017: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/28458564/radiobiological-evaluation-of-simultaneously-dose-escalated-versus-non-escalated-intensity-modulated-radiation-therapy-for-patients-with-upper-thoracic-esophageal-cancer
#6
Bao-Tian Huang, Li-Li Wu, Long-Jia Guo, Liang-Yu Xu, Rui-Hong Huang, Pei-Xian Lin, Jian-Zhou Chen, De-Rui Li, Chuang-Zhen Chen
OBJECTIVE: To compare the radiobiological response between simultaneously dose-escalated and non-escalated intensity-modulated radiation therapy (DE-IMRT and NE-IMRT) for patients with upper thoracic esophageal cancer (UTEC) using radiobiological evaluation. METHODS: Computed tomography simulation data sets for 25 patients pathologically diagnosed with primary UTEC were used in this study. DE-IMRT plan with an escalated dose of 64.8 Gy/28 fractions to the gross tumor volume (GTV) and involved lymph nodes from 25 patients pathologically diagnosed with primary UTEC, was compared to an NE-IMRT plan of 50...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28446938/minimally-invasive-surgery-for-resection-of-ossification-of-the-ligamentum-flavum-in-the-thoracic-spine
#7
Wei Zhao, Chaoxiong Shen, Ranze Cai, Jianfeng Wu, Yuandong Zhuang, Zhaowen Cai, Rui Wang, Chunmei Chen
INTRODUCTION: Thoracic ossification of the ligamentum flavum (TOLF) is a common cause of progressive thoracic myelopathy. Surgical decompression is commonly used to treat TOLF. AIM: To evaluate the clinical outcomes of microsurgical decompression of TOLF via a paraspinal approach, using a percutaneous tubular retractor system. MATERIAL AND METHODS: First, three-dimensional (3D) image reconstruction and printed models were made from thin computed tomography scans for each patient...
2017: Wideochirurgia i Inne Techniki Mało Inwazyjne, Videosurgery and Other Miniinvasive Techniques
https://www.readbyqxmd.com/read/28412561/metastatic-human-breast-cancer-to-the-spine-produces-mechanical-hyperalgesia-and-gait-deficits-in-rodents
#8
Rachel Sarabia-Estrada, Alejandro Ruiz-Valls, Hugo Guerrero-Cazares, Ana M Ampuero, Ismael Jimenez-Estrada, Samantha De Silva, Lydia J Bernhardt, C Rory Goodwin, A Karim Ahmed, Yuxin Li, Neil A Phillips, Ziya L Gokaslan, Alfredo Quiñones-Hinojosa, Daniel M Sciubba
BACKGROUND CONTEXT: Metastases to the spine are a common source of severe pain in cancer patients. The secondary effects of spinal metastases include pain, bone fractures, hypercalcemia, and neurological deficits. As the disease progresses, pain severity can increase until it becomes refractory to medical treatments and leads to a decreased quality of life for patients. A key obstacle in the study of pain-induced spinal cancer is the lack of reliable and reproducible spine cancer animal models...
April 13, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28368982/spinal-cord-stimulation-in-chronic-pain-mode-of-action
#9
Ricardo Vallejo, Kerry Bradley, Leonardo Kapural
OBJECTIVE: A review of the literature that presents a perspective on mechanisms of actions behind spinal cord stimulation (SCS) therapy for chronic pain. SUMMARY OF BACKGROUND DATA: SCS is an effective therapeutic alternative for the treatment of intractable chronic pain. Its application has been mostly based on the Gate Control Theory (GCT) of pain. Computational models have been fundamental on the understanding of clinical observations and the design of therapies that provide optimal neuromodulation...
March 31, 2017: Spine
https://www.readbyqxmd.com/read/28350952/future-advances-in-spine-surgery-the-aospine-north-america-perspective
#10
Michael G Fehlings, Christopher S Ahuja, Thomas Mroz, Wellington Hsu, James Harrop
This focus issue highlights state-of-the-art techniques, equipment, and practices in the modern era of spine surgery while providing a glimpse into the next generation of patient care. A broad range of topics are presented to cover the full spectrum of the field. Degenerative diseases are discussed in a series of 3 articles on (1) pathophysiology, management, and surgical approaches to degenerative cervical myelopathy; (2) novel approaches to degenerative thoracolumbar disease (eg, interspinous process spacers, minimally invasive/endoscopic approaches); and (3) animal models and emerging therapeutics in degenerative disk disease...
March 1, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28324978/influence-of-electrode-configuration-on-the-electric-field-distribution-during-transcutaneous-spinal-direct-current-stimulation-of-the-cervical-spine
#11
Sofia R Fernandes, Ricardo Salvador, Cornelia Wenger, Mamede A de Carvalho, Pedro C Miranda
Transcutaneous spinal direct current stimulation (tsDCS) is a recent technique with promising neuromodulatory effects on spinal neuronal circuitry. The main objective of the present study was to perform a finite element analysis of the electric field distribution in tsDCS in the cervical spine region, with varying electrode configurations and geometry. A computational model of a human trunk was generated with nine tissue meshes. Three electrode configurations were tested: A) rectangular saline-soaked sponge target and return electrodes placed over C3 and T3 spinous processes, respectively; B1) circular saline-soaked sponge target and return electrodes placed over C7 spinous process and right deltoid muscle, respectively; B2) same configuration as B1, considering circular shaped electrodes with sponge and rubber layers and a small circular connector on the top surface...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28324946/characterization-of-motor-cortex-activity-of-the-lower-limb-region
#12
Fadi Mikhail, Karthikeyan Balasubramanian, Matthew D Best, Kazutaka Takahashi, Nicholas G Hatsopoulos
Understanding the functional properties of the motor cortex is a key step to developing effective neuroprosthetic and computer interfaces for amputees and patients with spinal cord injury. Most efforts have been directed towards studying the upper limb region of the motor cortex. Little has been done in the way of addressing lower limb motor cortical physiology. In this study, we implanted multiple microelectrode arrays along the central sulcus in the primary motor cortex of a macaque monkey. Using intracortical microstimulation, we identified neurons that evoked leg movements, either exclusively or mostly, and we studied their firing activity during a center-out arm movement task...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28269725/computational-models-of-non-invasive-brain-and-spinal-cord-stimulation
#13
Pedro C Miranda, Ricardo Salvador, Cornelia Wenger, Sofia R Fernandes
Non-invasive brain and spinal cord stimulation techniques are increasingly used for diagnostic and therapeutic purposes. Knowledge of the spatial distribution of the induced electric field is necessary to interpret experimental results and to optimize field delivery. Since the induced electric field cannot be measured in vivo in humans, computational models play a fundamental role in determining the characteristics of the electric field. We produced computational models of the head and trunk to calculate the electric field induced in the brain and spinal cord by transcranial magnetic stimulation, transcranial direct current stimulation and transcutaneous spinal cord direct current stimulation...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268678/novel-fractal-planar-electrode-design-for-efficient-neural-stimulation
#14
Xuefeng Wei, Mehdi Benmassaoud, Miriam Meller, Sindhuja Kuchibhatla
Planar electrodes are used in epidural spinal cord stimulation and cortical stimulation. Stimulation efficiency of an electrode is characterized by its ability to activate a volume of neural tissue with lower voltage and power requirements. As current density tends to increase towards the sharp edges of an electrode, we hypothesize that electrode designs involving a greater amount of sharp edges will have higher variations of current density, and therefore increase stimulation efficiency, compared to electrodes with flat or rounded edges...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28266523/abnormalities-in-a-to-i-rna-editing-patterns-in-cns-injuries-correlate-with-dynamic-changes-in-cell-type-composition
#15
Nurit Gal-Mark, Lea Shallev, Sahar Sweetat, Michal Barak, Jin Billy Li, Erez Y Levanon, Eli Eisenberg, Oded Behar
Adenosine to Inosine (A-to-I) RNA editing is a co- or post-transcriptional mechanism that modifies genomically encoded nucleotides at the RNA level. A-to-I RNA editing is abundant in the brain, and altered editing levels have been reported in various neurological pathologies and following spinal cord injury (SCI). The prevailing concept is that the RNA editing process itself is dysregulated by brain pathologies. Here we analyzed recent RNA-seq data, and found that, except for few mammalian conserved editing sites, editing is significantly higher in neurons than in other cell populations of the brain...
March 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28227989/computational-models-of-non-invasive-brain-and-spinal-cord-stimulation
#16
Pedro C Miranda, Ricardo Salvador, Cornelia Wenger, Sofia R Fernandes, Pedro C Miranda, Ricardo Salvador, Cornelia Wenger, Sofia R Fernandes, Sofia R Fernandes, Pedro C Miranda, Cornelia Wenger, Ricardo Salvador
Non-invasive brain and spinal cord stimulation techniques are increasingly used for diagnostic and therapeutic purposes. Knowledge of the spatial distribution of the induced electric field is necessary to interpret experimental results and to optimize field delivery. Since the induced electric field cannot be measured in vivo in humans, computational models play a fundamental role in determining the characteristics of the electric field. We produced computational models of the head and trunk to calculate the electric field induced in the brain and spinal cord by transcranial magnetic stimulation, transcranial direct current stimulation and transcutaneous spinal cord direct current stimulation...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227179/influence-of-electrode-configuration-on-the-electric-field-distribution-during-transcutaneous-spinal-direct-current-stimulation-of-the-cervical-spine
#17
Sofia R Fernandes, Ricardo Salvador, Cornelia Wenger, Mamede A de Carvalho, Pedro C Miranda, Sofia R Fernandes, Ricardo Salvador, Cornelia Wenger, Mamede A de Carvalho, Pedro C Miranda, Sofia R Fernandes, Pedro C Miranda, Cornelia Wenger, Ricardo Salvador, Mamede A de Carvalho
Transcutaneous spinal direct current stimulation (tsDCS) is a recent technique with promising neuromodulatory effects on spinal neuronal circuitry. The main objective of the present study was to perform a finite element analysis of the electric field distribution in tsDCS in the cervical spine region, with varying electrode configurations and geometry. A computational model of a human trunk was generated with nine tissue meshes. Three electrode configurations were tested: A) rectangular saline-soaked sponge target and return electrodes placed over C3 and T3 spinous processes, respectively; B1) circular saline-soaked sponge target and return electrodes placed over C7 spinous process and right deltoid muscle, respectively; B2) same configuration as B1, considering circular shaped electrodes with sponge and rubber layers and a small circular connector on the top surface...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226862/novel-fractal-planar-electrode-design-for-efficient-neural-stimulation
#18
Xuefeng Wei, Mehdi Benmassaoud, Miriam Meller, Sindhuja Kuchibhatla, Xuefeng Wei, Mehdi Benmassaoud, Miriam Meller, Sindhuja Kuchibhatla, Mehdi Benmassaoud, Sindhuja Kuchibhatla, Miriam Meller, Xuefeng Wei
Planar electrodes are used in epidural spinal cord stimulation and cortical stimulation. Stimulation efficiency of an electrode is characterized by its ability to activate a volume of neural tissue with lower voltage and power requirements. As current density tends to increase towards the sharp edges of an electrode, we hypothesize that electrode designs involving a greater amount of sharp edges will have higher variations of current density, and therefore increase stimulation efficiency, compared to electrodes with flat or rounded edges...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28218643/diffusion-assessment-of-cortical-changes-induced-by-traumatic-spinal-cord-injury
#19
Peng Sun, Rory K J Murphy, Paul Gamble, Ajit George, Sheng-Kwei Song, Wilson Z Ray
Promising treatments are being developed to promote functional recovery after spinal cord injury (SCI). Magnetic resonance imaging, specifically Diffusion Tensor Imaging (DTI) has been shown to non-invasively measure both axonal and myelin integrity following traumatic brain and SCI. A novel data-driven model-selection algorithm known as Diffusion Basis Spectrum Imaging (DBSI) has been proposed to more accurately delineate white matter injury. The objective of this study was to investigate whether DTI/DBSI changes that extend to level of the cerebral peduncle and internal capsule following a SCI could be correlated with clinical function...
February 17, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28192461/canine-neuroanatomy-development-of-a-3d-reconstruction-and-interactive-application-for-undergraduate-veterinary-education
#20
Hazel Raffan, Julien Guevar, Matthieu Poyade, Paul M Rea
Current methods used to communicate and present the complex arrangement of vasculature related to the brain and spinal cord is limited in undergraduate veterinary neuroanatomy training. Traditionally it is taught with 2-dimensional (2D) diagrams, photographs and medical imaging scans which show a fixed viewpoint. 2D representations of 3-dimensional (3D) objects however lead to loss of spatial information, which can present problems when translating this to the patient. Computer-assisted learning packages with interactive 3D anatomical models have become established in medical training, yet equivalent resources are scarce in veterinary education...
2017: PloS One
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