keyword
https://read.qxmd.com/read/32899442/pathways-of-gastric-carcinogenesis-helicobacter-pylori-virulence-and-interactions-with-antioxidant-systems-vitamin-c-and-phytochemicals
#21
REVIEW
James W T Toh, Robert B Wilson
Helicobacter pylori is a class one carcinogen which causes chronic atrophic gastritis, gastric intestinal metaplasia, dysplasia and adenocarcinoma. The mechanisms by which H. pylori interacts with other risk and protective factors, particularly vitamin C in gastric carcinogenesis are complex. Gastric carcinogenesis includes metabolic, environmental, epigenetic, genomic, infective, inflammatory and oncogenic pathways. The molecular classification of gastric cancer subtypes has revolutionized the understanding of gastric carcinogenesis...
September 3, 2020: International Journal of Molecular Sciences
https://read.qxmd.com/read/32690815/involvement-of-autophagy-in-antibacterial-actions-of-vitamin-d-in-helicobacter-pylori-infection-abridged-secondary-publication
#22
JOURNAL ARTICLE
W Hu, L Zhang, W K K Wu, C H Cho
No abstract text is available yet for this article.
June 2020: Hong Kong Medical Journal
https://read.qxmd.com/read/32276153/aetiology-of-nutritional-rickets-in-rural-bangladeshi-children
#23
JOURNAL ARTICLE
Sonia Ahmed, Gail R Goldberg, Rubhana Raqib, Swapan Kumar Roy, Shahidul Haque, Vickie S Braithwaite, John M Pettifor, Ann Prentice
OBJECTIVES: A high prevalence of rickets of unknown aetiology has been reported in Chakaria, Bangladesh. Classically, rickets is caused by vitamin D deficiency but increasing evidence from Africa and Asia points towards other nutritional deficiencies or excessive exposure to some metals. The aim of this study was to investigate the aetiology of rickets in rural Bangladeshi children. METHODS: 64 cases with rickets-like deformities were recruited at first presentation together with age-sex-village matched controls...
July 2020: Bone
https://read.qxmd.com/read/31955643/-helicobacter-pylori-antibiotic-eradication-coupled-with-a-chemically-defined-diet-in-ins-gas-mice-triggers-dysbiosis-and-vitamin-k-deficiency-resulting-in-gastric-hemorrhage
#24
JOURNAL ARTICLE
Lisa Quinn, Alexander Sheh, Jessie L Ellis, Donald E Smith, Sarah L Booth, Xueyan Fu, Sureshkumar Muthupalani, Zhongming Ge, Dylan A Puglisi, Timothy C Wang, Tamas A Gonda, Hilda Holcombe, James G Fox
Infection with Helicobacter pylori causes chronic inflammation and is a risk factor for gastric cancer. Antibiotic treatment or increased dietary folate prevents gastric carcinogenesis in male INS-GAS mice. To determine potential synergistic effects, H. pylori -infected male INS-GAS mice were fed an amino acid defined (AAD) diet with increased folate and were treated with antibiotics after 18 weeks of H. pylori infection. Antibiotic therapy decreased gastric pathology, but dietary folate had no effect. However, the combination of antibiotics and the AAD diet induced anemia, gastric hemorrhage, and mortality...
July 3, 2020: Gut Microbes
https://read.qxmd.com/read/31784293/feeding-problems-and-gastrointestinal-diseases-in-down-syndrome
#25
REVIEW
A Ravel, C Mircher, A-S Rebillat, C Cieuta-Walti, A Megarbane
BACKGROUND AND METHOD: Feeding problems and gastrointestinal disorders are the most common anomalies in people with Down syndrome (DS) and have a significant impact on their daily life. This study lists the various anomalies on the basis of 504 references selected from a PubMed search in October 2018. RESULTS: The anomalies are grouped into three categories: anatomical anomalies: duodenal atresia and stenosis (3.9%), duodenal web and annular pancreas; aberrant right subclavian artery (12% of children with DS with cardiac anomaly); Hirschsprung's disease (2...
January 2020: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://read.qxmd.com/read/31616528/-helicobacter-pylori-infection-coexisting-with-intestinal-metaplasia-is-not-associated-with-colorectal-neoplasms
#26
JOURNAL ARTICLE
Banu Boyuk, Arif Ozgur, Hande Atalay, Aslan Celebi, Ismail Ekizoglu, Engin Aykurt
INTRODUCTION: Colorectal cancer is one of the most common cancers and is a major cause of morbidity and mortality in the world and our country. Studies have indicated that there might be a relationship between Helicobacter pylori (Hp) and colorectal neoplasia (CN), although others have not found any relationship. AIM: To determine whether there is a potential relationship between Hp and CN in our patients. MATERIAL AND METHODS: A total of 314 patients, aged 16-86 years, who underwent gastroscopy and colonoscopy at our department between 2015 and 2017 were evaluated retrospectively...
2019: Przegla̜d Gastroenterologiczny
https://read.qxmd.com/read/31511230/effects-of-helicobacter-pylori-treatment-and-vitamin-and-garlic-supplementation-on-gastric-cancer-incidence-and-mortality-follow-up-of-a-randomized-intervention-trial
#27
RANDOMIZED CONTROLLED TRIAL
Wen-Qing Li, Jing-Yu Zhang, Jun-Ling Ma, Zhe-Xuan Li, Lian Zhang, Yang Zhang, Yang Guo, Tong Zhou, Ji-You Li, Lin Shen, Wei-Dong Liu, Zhong-Xiang Han, William J Blot, Mitchell H Gail, Kai-Feng Pan, Wei-Cheng You
OBJECTIVE: To assess the effects of Helicobacter pylori treatment, vitamin supplementation, and garlic supplementation in the prevention of gastric cancer. DESIGN: Blinded randomized placebo controlled trial. SETTING: Linqu County, Shandong province, China. PARTICIPANTS: 3365 residents of a high risk region for gastric cancer. 2258 participants seropositive for antibodies to H pylori were randomly assigned to H pylori treatment, vitamin supplementation, garlic supplementation, or their placebos in a 2×2×2 factorial design, and 1107 H pylori seronegative participants were randomly assigned to vitamin supplementation, garlic supplementation, or their placebos in a 2×2 factorial design...
September 11, 2019: BMJ: British Medical Journal
https://read.qxmd.com/read/31145549/influence-of-serum-vitamin-d-level-on-helicobacter-pylori-eradication-a-multi-center-observational-prospective-and-cohort-study
#28
JOURNAL ARTICLE
Chuan Han, Zhen Ni, Ting Yuan, Jian Zhang, Chan Wang, Xin Wang, Han Bing Ning, Jie Liu, Nina Sun, Cai Fang Liu, Miao Shi, Wen Quan Lu, Yong Quan Shi
OBJECTIVES: This study was designed to test whether serum vitamin D levels affected Helicobacter pylori (H. pylori) infection and eradication rates. METHODS: A multicenter observational prospective cohort study was conducted. A total of 496 H. pylori- positive (H. pylori+ ) and 257 H. pylori-negative (H. pylori- ) patients were enrolled from four hospitals in China. Baseline serum vitamin D levels were measured and a 13 C-urea breath test (UBT) was performed for all the participants...
August 2019: Journal of Digestive Diseases
https://read.qxmd.com/read/30873873/dietary-intake-of-nutrients-involved-in-one-carbon-metabolism-and-risk-of-gastric-cancer-a-prospective-study
#29
JOURNAL ARTICLE
Pierre-Antoine Dugué, Julie K Bassett, Maree T Brinkman, Melissa C Southey, Jihoon E Joo, Ee Ming Wong, Roger L Milne, Dallas R English, Graham G Giles, Alex Boussioutas, Hazel Mitchell, Allison M Hodge
Dietary intakes of B vitamins and other components involved in one-carbon metabolism, which is necessary for DNA replication, DNA repair, and regulation of gene expression, may be associated with carcinogenesis. We investigated associations between intakes of 11 nutrients (thiamine, riboflavin, niacin, pantothenic acid, vitamin B6, biotin, folate, vitamin B12, methionine, choline, and betaine) and gastric cancer risk. A total of 159 incident gastric cancer cases were identified from the Melbourne Collaborative Cohort Study (N = 41,513) and matched with 159 controls on year of birth, sex, and country of birth using incidence density sampling...
2019: Nutrition and Cancer
https://read.qxmd.com/read/30759976/helicobacter-pylori-and-nutrition-a-bidirectional-communication
#30
REVIEW
Umberto Aimasso, Valentina D'onofrio, Chiara D'eusebio, Andrea Devecchi, Costanza Pira, Fabio D Merlo, Antonella De Francesco
Helicobacter pylori (HP) is a gram-negative flagellated pathogen acid-resistant bacterium; it belongs to the order Campylobacterales that is wide spread all over the world, infecting more than 50% of the world population. HP infection is etiologically associated with non-atrophic and atrophic gastritis, peptic ulcer and with 3 to 6-fold increased relative risk for developing gastric adenocarcinoma and mucosa-associated lymphoid tissue (MA LT) lymphoma. For this reason HP is recognized by the World Health Organization as a Class I human carcinogen...
June 2019: Minerva Gastroenterologica e Dietologica
https://read.qxmd.com/read/30641993/association-of-tlr4-polymorphisms-expression-and-vitamin-d-with-helicobacter-pylori-infection
#31
JOURNAL ARTICLE
Shafika Assaad, Christy Costanian, Lama Jaffal, Fida Tannous, Maria G Stathopoulou, Said El Shamieh
Helicobacter pylori ( H. pylori ) infection is the strongest recognized risk factor for gastric adenocarcinoma. Since previous observations have shown that polymorphisms in innate immune system genes, as well as vitamin D (VitD) levels, could modify the risk of infection with Helicobacter pylori ( H. pylori ), we analyzed the relation between single nucleotide polymorphisms (SNPs) in TLRs ( TLR1 , TLR2 , TLR4 ) CD14 , RUNX3 and VitD levels with H. pylori infection. A case-control study on four hundred sixty Lebanese individuals was conducted...
January 11, 2019: Journal of Personalized Medicine
https://read.qxmd.com/read/30612517/vitamin-d3-activates-the-autolysosomal-degradation-function-against-helicobacter-pylori-through-the-pdia3-receptor-in-gastric-epithelial-cells
#32
JOURNAL ARTICLE
Wei Hu, Lin Zhang, Ming Xing Li, Jing Shen, Xiao Dong Liu, Zhan Gang Xiao, Ding Lan Wu, Idy H T Ho, Justin C Y Wu, Cynthia K Y Cheung, Yu Chen Zhang, Alaster H Y Lau, Hassan Ashktorab, Duane T Smoot, Evandro F Fang, Matthew T V Chan, Tony Gin, Wei Gong, William K K Wu, Chi Hin Cho
Helicobacter pylori (H. pylori) is a common human pathogenic bacterium. Once infected, it is difficult for the host to clear this organism using the innate immune system. Increased antibiotic resistance further makes it challenging for effective eradication. However, the mechanisms of immune evasion still remain obscure, and novel strategies should be developed to efficiently eliminate H. pylori infection in stomachs. Here we uncovered desirable anti-H. pylori effect of vitamin D3 both in vitro and in vivo, even against antibiotic-resistant strains...
April 2019: Autophagy
https://read.qxmd.com/read/30542778/effect-of-25-hydroxyvitamin-d-on-helicobacter-pylori-eradication-in-patients-with-type-2-diabetes
#33
JOURNAL ARTICLE
Bin Huang, Shenju Yan, Chao Chen, Shandong Ye
BACKGROUND: Various studies have reported a lower Helicobacter pylori eradication rate and a more frequent reinfection rate in type 2 diabetes mellitus (T2DM). Vitamin D has anti-inflammatory and immunoregulatory activity and the role of the vitamin D receptor (VDR) in the antimicrobial activity against H. pylori has been reported. When it comes to the risk factors of H. pylori eradication, the function of vitamin D is not always taken into account. The aim of this study was to assess the role of 25-hydroxyvitamin D in H...
December 12, 2018: Wiener Klinische Wochenschrift
https://read.qxmd.com/read/30280058/vitamin-c-a-preventative-therapeutic-agent-against-helicobacter-pylori
#34
REVIEW
Azhar Hussain, Elsa Tabrez, Jagannadha Peela, Prasanna Honnavar, Shams S M Tabrez
The treatment of Helicobacter pylori ( H. pylori ) induced infections using antibiotic therapies is clinically well accepted; however, using a noninvasive approach with the implementation of therapeutic agents such as vitamin C is not well investigated. Vitamin C has certain characteristics, which allow for it to be considered as a potential treatment option for patients with H. pylori infections. Vitamin C's hostility and mechanism of action towards H. pylori infection in peptic ulcer disease can be classified into two categories: as a preventative agent and alternatively as a therapeutic agent...
July 30, 2018: Curēus
https://read.qxmd.com/read/30181749/the-association-between-index-of-nutritional-quality-and-ulcerative-colitis-a-case-control-study
#35
JOURNAL ARTICLE
Farhad Vahid, Samaneh Rashvand, Mahya Sadeghi, Azita Hekmatdoost
Background: Ulcerative colitis (UC) is a chronic inflammatory bowel disease. Recent studies have shown that dietary factors play an important role in the development of UC. Index of Nutritional Quality (INQ) is a suitable method that analyzes quantitatively and qualitatively single foods, meals, and diets. The aim of this study was to determine the association between INQ and UC. Materials and Methods: Overall, 62 newly diagnosed cases with UC and 124 healthy age- and sex-matched controls were studied in a referral hospital in Tabriz, Iran...
2018: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://read.qxmd.com/read/30160114/effects-of-natural-flavonoid-isoorientin-on-growth-performance-and-gut-microbiota-of-mice
#36
JOURNAL ARTICLE
Li Yuan, Xueyi Li, Shenyuan He, Chunxia Gao, Chengtao Wang, Yuyu Shao
Isoorientin (ISO) is a natural flavonoid, which is a 6- C-glucoside of luteolin, and has been demonstrated to possess multiple biological properties. In this study, the effects of ISO on the growth performance and gut microbiota of BALB/c mice were investigated. The results showed that ISO could promote food intake and body weight gain, increase the digestibility of crude proteins and utilization of the gross energy, and strengthen antioxidant capacity of mice. We also demonstrated it has no side effects on hepatic and renal functions...
September 19, 2018: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/30154733/vitamin-c-and-helicobacter-pylori-infection-current-knowledge-and-future-prospects
#37
REVIEW
Haixin Mei, Hongbin Tu
The gram-negative bacterium, Helicobacter pylori ( H. pylori ), infection is predominantly known for its strong association with development of gastric diseases, including gastritis, peptic ulcers, and stomach cancer. Numerous clinical reports show that ascorbic acid deficiency has been connect with gastritis. Vitamin C levels both in gastric acid and serum have constantly been affirmed to be low in subjects with H. pylori infected gastritis and peptic ulcers. Ascorbic acid supplementation likely relates to reduced incidences of bleeding from peptic ulcers and gastric cancer...
2018: Frontiers in Physiology
https://read.qxmd.com/read/29102269/assessment-of-the-use-of-vitamin-c-and-e-supplements-concomitantly-to-antibiotic-treatment-against-helicobacter-pylori-a-systematic-review-and-meta-analysis
#38
JOURNAL ARTICLE
Edgar Yaset Caicedo Ochoa, César Orlando Quintero Moreno, Yardany Rafael Méndez Fandiño, Sofía Catalina Sánchez Fonseca, Héctor Fabio Cortes Motta, Santiago Alejandro Guio Guerra
INTRODUCTION: Helicobacter pylori infections affect almost 50% of the world population, constituting a risk factor for benign and malignant gastrointestinal diseases. The increased resistance to antibiotic treatment against this infection represents a dilemma in the search of other therapeutic alternatives. OBJECTIVE: To determine the efficacy of the use of vitaminC and E supplements concomitantly to antibiotic treatment against H. pylori infections. METHODS: We performed a systematic review on the MedLine (PubMed), Embase and Cochrane Central Register of Clinical Trials (CENTRAL) databases, searching for studies evaluating the efficacy of vitaminC and/or E supplements in the antibiotic treatment of H...
July 23, 2018: Medicina Clínica
https://read.qxmd.com/read/29080461/l-ascorbic-acid-2-glucoside-inhibits-helicobacter-pylori-induced-apoptosis-through-mitochondrial-pathway-in-gastric-epithelial-cells
#39
JOURNAL ARTICLE
Xiong Chen, Rui Liu, Xiaoming Liu, Canxia Xu, Xiaoyan Wang
Helicobacter pylori (H. pylori) infection is the major cause for gastritis, peptic ulcer, and gastric cancer. Elevated oxidative stress, mitochondrial dysfunction and apoptotic death of gastric epithelial cells are typical hallmarks of H. pylori infection. Ascorbic Acid 2-Glucoside (AA2G) is a stable version of Vitamin C, that binds glucose to conventional vitamin C. AA2G has free radical scavenging activities and anti-apoptotic abilities. However, the protective effect of AA2G against H. pylori-infection in gastric epithelial cells is yet unknown...
January 2018: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/28821981/modifiable-factors-and-esophageal-cancer-a-systematic-review-of-published-meta-analyses
#40
JOURNAL ARTICLE
Clara Castro, Bárbara Peleteiro, Nuno Lunet
There are marked differences in the etiology of the major histological types of esophageal cancer (EC)-squamous cell carcinomas (ESCC) and adenocarcinomas (EAC). This study aimed to summarize the current scientific knowledge on modifiable risk factors for EC, by histological type, through a systematic review of meta-analyses referenced in PubMed and ISI Web of Knowledge. We identified 100 meta-analyses on risk factors for ESCC (n = 54), EAC (n = 43), or EC (n = 51). ESCC risk significantly increased with alcohol and maté drinking, smoking, red and processed meat consumption and human papillomavirus infection, while it was negatively associated with body mass index and consumption of fruit, vegetables, white meat, folate, and some carotenoids...
January 2018: Journal of Gastroenterology
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