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helicobacter pylori vitamin c

Lei Huang, Aman Xu
To date, gastric carcinoma (GC) is one of the common and fatal digestive malignancies worldwide. The prognosis of GC is not always satisfactory because of late diagnosis. Scholars are keen on discovering novel accurate and economical biomarkers in body liquids for GC screening to detect and evaluate the lesion before the results of imaging techniques are obtained. While traditional serum assays have limited sensitivity and specificity, gastrointestinal juice may provide relevant specific biomarkers because of its close contact with the tumor...
February 17, 2017: Frontiers of Medicine
Marko Skelin, Tomo Lucijanić, Daniela Amidžić Klarić, Arnes Rešić, Miro Bakula, Ana-Marija Liberati-Čizmek, Hossein Gharib, Dario Rahelić
PURPOSE: Levothyroxine (LT4) is a drug with a narrow therapeutic index, applied in small amounts (micrograms), which makes interactions in the absorption phase clinically significant. The main aim of this article was to review and present the latest information on factors that affect the gastrointestinal absorption of this drug. METHODS: Relevant data were collected by using the MEDLINE, PubMed, EMBASE, Web of Science, Science Direct, and Scopus databases with the key words levothyroxine and absorption...
February 2017: Clinical Therapeutics
Bach Viet Hoang, Jeonghee Lee, Il Ju Choi, Young-Woo Kim, Keun Won Ryu, Jeongseon Kim
AIM: To investigate the effects of dietary vitamin C and foods containing vitamin C on gastric cancer risk. METHODS: Our study included 830 control subjects and 415 patients. Data regarding demographics, medical history, and lifestyle, including dietary and nutrient intake, were collected using reliable self-administered questionnaires. Dietary intake information was collected from the participants using a food frequency questionnaire that has been previously reported as reliable and valid...
July 21, 2016: World Journal of Gastroenterology: WJG
Tsuyoshi Yamamoto, Hidenori Matsui, Kenzaburo Yamaji, Tetsufumi Takahashi, Anders Øverby, Masahiko Nakamura, Atsuko Matsumoto, Kenichi Nonaka, Toshiaki Sunazuka, Satoshi Ōmura, Hirofumi Nakano
We aimed to identify narrow-spectrum natural compounds that specifically inhibit an alternative menaquinone (MK; vitamin K2) biosynthetic pathway (the futalosine pathway) of Helicobacter pylori. Culture broth samples of 6183 microbes were examined using the paper disc method with different combinations of 2 of the following 3 indicator microorganisms: Bacillus halodurans C-125 and Kitasatospora setae KM-6054(T), which have only the futalosine pathway of MK biosynthesis, and Bacillus subtilis H17, which has only the canonical MK biosynthetic pathway...
September 2016: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
Li-Wei Chen, Chih-Yi Chien, Chia-Wen Hsieh, Liang-Che Chang, Mei-Huei Huang, Wen-Yuan Huang, Sheng-Fong Kuo, Cheng-Hung Chien, Chih-Lang Lin, Rong-Nan Chien
The associations between Helicobacter pylori infection, serum vitamin D level, and metabolic syndrome (MS) are controversial. The present community-based study aimed to investigate the effect of H pylori infection and serum vitamin D deficiency on MS development.Individuals from the northeastern region of Taiwan were enrolled in a community-based study from March, 2014 to August, 2015. All participants completed a demographic survey and underwent the urea breath test (UBT) to detect H pylori infection as well as blood tests to determine levels of vitamin D, adiponectin, leptin, and high-sensitivity C-reactive protein...
May 2016: Medicine (Baltimore)
Hakan Demirci, Kadir Ozturk, Omer Kurt
We read the article "Effects of daily telephone-based re-education before taking medicine on Helicobacter pylori (H. pylori) eradication: A prospective single-center study from China" written by Wang et al with great interest. It is reported in American and European guidelines that there is no sufficient test for the diagnosis of H. pylori except culture and that using at least two different tests for diagnosis of H. pylori is recommended. Patients who used antibiotics or bismuth salts in the previous 2 wk were excluded from study...
April 21, 2016: World Journal of Gastroenterology: WJG
Hakan Demirci, Sevil Uygun İlikhan, Kadir Öztürk, Yücel Üstündağ, Ömer Kurt, Muammer Bilici, Furuzan Köktürk, Ahmet Uygun
BACKGROUND/AIMS: In our study, we aimed to assess the effect of vitamin E and C supplementation to triple and quadruple Helicobacter pylori eradication regimens. MATERIALS AND METHODS: Four hundred patients with H. pylori infection were classified into four groups. Patients in group A (n=100) received amoxicillin, clarithromycin, and lansoprazole for 2 weeks. In group B, patients (n=100) received vitamins C and E for a month, in addition to amoxicillin, clarithromycin, and lansoprazole for 2 weeks...
November 2015: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
Yarasi Gayathri Ramakrishna, Kumarasamy Savithri, Manfred Kist, Sivasitamparam Niranjali Devaraj
BACKGROUND: Bael (Aegle marmelos (L.) Corr.) has been widely used in indigenous systems of Indian medicine to exploit its medicinal properties including astringent, antidiarrheal, antidysenteric, demulcent, antipyretic, antiulcer, anti-inflammatory and anti cancer activities. The present study aims to evaluate the antioxidative and antiulcer effect of methanolic extract of unripe fruit of Aegle marmelos (MEAM) against Helicobacter pylori-Lipopolysaccharide (HP-LPS) induced gastric ulcer in Sprague Dawley (SD) rats...
2015: BMC Complementary and Alternative Medicine
Oguz Afyoncu, Orhan Gursel, Avni Atay, Emin Kurekci, Necati Balamtekin, Adnan Hasimi, Mehmet A Ozguven, Okan Ozcan
BACKGROUND: The purpose of this study was to evaluate the association between vitamin B12 levels and Helicobacter Pylori infection and to examine the clinical usefulness of holotranscobalamin (holoTC) measurement in children. MATERIALS AND METHODS: Thirty patients between 6 and 15 years of age, who were diagnosed as H. pylori infected by C(14) urea breath test, and 26 controls were enrolled in the study. Tests for complete blood count, serum vitamin B12 and folate, plasma total homocysteine, and holoTC levels were performed in each patient in the study and control groups...
February 2016: Helicobacter
Shrikant C Raut, Vinayak W Patil, Shubhangi M Dalvi, Girish D Bakhshi
Helicobacter pylori are considered the most common human pathogen colonizing gastric mucosa. Gastritis with or without H. pylori infection is associated with increase in levels of homocysteine and high-sensitivity C-reactive protein (hs-CRP) but a more pronounced increase is noted in gastritis with H. pylori infection. Increasing level of homocysteine, due to decreased absorption of vitamin B12 and folic acid, together with increased CRP levels in gastritis with H. pylori infection may be the earliest event in the process of atherosclerosis and plaque formation...
January 28, 2015: Clinics and Practice
May A Beydoun, Greg A Dore, Jose A Canas, Hind A Beydoun, Alan B Zonderman
OBJECTIVES: We tested a model in which Helicobacter pylori seropositivity (Hps) predicted iron status, which in turn acted as a predictor for markers of 1-C metabolism that were then allowed to predict antioxidant status. METHODS: National Health and Nutrition Examination Surveys (NHANES 1999-2000) cross-sectional data among adults aged 20-85 y were analyzed (n = 3,055). Markers of Hps, iron status (serum ferritin and transferrin saturation (TS)); 1-C metabolism (serum folate (FOLserum), B-12, total homocysteine (tHcy), methylmalonic acid (MMA)) and antioxidant status (vitamins A and E) were entered into a structural equations model (SEM)...
2015: PloS One
Kouichi Hosoda, Hirofumi Shimomura, Kiyofumi Wanibuchi, Hisashi Masui, Avarzed Amgalanbaatar, Shunji Hayashi, Takashi Takahashi, Yoshikazu Hirai
This study demonstrated that the vitamin D₃ decomposition product VDP1 exerts an antibacterial action against Helicobacter pylori but not against other bacteria. Treatment with VDP1 induced a collapse of cell membrane structures of H. pylori and ultimately lysed the bacterial cells. A unique dimyristoyl phosphatidylethanolamine in the membrane lipid compositions contributed to the interaction of VDP1 with H. pylori cells. In separate experiments, VDP1 had no influence on the viability of the human cancer cell lines MKN45 and T47D and lacked any vitamin D₃-like hormonal action against the latter...
2015: Scientific Reports
R Pellicano, D G Ribaldone, G M Saracco, N Leone, C De Angelis, A Arrigoni, E Morello, N Sapone, F Cisarò, M Astegiano
AIM: Functional dyspepsia, though benign, leads to deterioration of the quality of life and high costs for healthcare systems. The optimal therapy for functional dyspepsia is still to be defined because of its multifactorial pathogenesis. In an open multicentric study of patients with functional dyspepsia, we prospectively evaluated the benefit of treatment with a food supplement composed of sodium alginate, carbonate calcium, pineapple, papaya, ginger, α-galactosidase and fennel (Perdiges, Bioten Snc, Turin, Italy)...
December 2014: Minerva Gastroenterologica e Dietologica
Amornset Tachaprutinun, Porntip Pan-In, Pawatsanai Samutprasert, Wijit Banlunara, Nuntaree Chaichanawongsaroj, Supason Wanichwecharungruang
The development of carriers to sustain drugs at stomach surface is an attractive strategy to increase drug bioavailability locally and systematically. So far, the only reported carrier that can form a covalent bond with mucus, the thiolated carrier, relies on a reversible disulfide exchange reaction between thiols on the carrier and disulfide bridges on the mucus. Here we show the design and fabrication of a cellulose carrier with tethering acrylate groups (denoted here as clickable carrier) that, under a nontoxic condition, can efficiently react with thiols on biomaterials in situ through the thermodynamically driven and kinetically probable Michael thiol-ene click reaction...
November 10, 2014: Biomacromolecules
Gwen Murphy, Angelika Michel, Philip R Taylor, Demetrius Albanes, Stephanie J Weinstein, Jarmo Virtamo, Dominick Parisi, Kirk Snyder, Julia Butt, Katherine A McGlynn, Jill Koshiol, Michael Pawlita, Gabriel Y Lai, Christian C Abnet, Sanford M Dawsey, Neal D Freedman
UNLABELLED: Helicobacter have been detected in human bile and hepatobiliary tissue. Despite evidence that Helicobacter species promote gallstone formation and hepatobiliary tumors in laboratory studies, it remains unclear whether Helicobacter species contribute to these cancers in humans. We used a multiplex panel to assess whether seropositivity to 15 Helicobacter pylori proteins was associated with subsequent incidence of hepatobiliary cancers in the Finnish Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study...
December 2014: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
Xi Liu, Hong Cheng, Wen Gao, Xinhong Dong, Fulian Hu
OBJECTIVE: To evaluate the efficacy, compliance and adverse effects of 14-day amoxicillin and furazolidone-based quadruple regimen as rescue treatment for Helicobacter pylori (H.pylori) infection. METHODS: A total of 228 patients positive for H.pylori with previous failed treatment at least once were enrolled into this retrospective study. There were 71 males and 157 females, aged (50 ± 13) years. A 14-day quadruple regimen was administered along with furazolidone, amoxicillin and bismuth citrate in combination with proton pump inhibitors...
March 4, 2014: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Jen-Yin Chen, Chia-Yu Chang, Kuo-Mao Lan, Ming-Jen Sheu, Chin-Li Lu, Miao-Lin Hu
Postherpetic neuralgia is the most common complication of herpes zoster which is caused by a reactivation of latent varicella zoster virus. The pathogenesis of postherpetic neuralgia may involve peripheral and central mechanisms. Reported risk factors for postherpetic neuralgia include female gender, old age, diminished cell-mediated immunity and nutritional deficiencies. Based on our clinical observation which revealed that peptic ulcer disease (PUD) is one of the common comorbidities in patients with postherpetic neuralgia, we hypothesize that herpes zoster patients with PUD may be at a greater risk for the development of postherpetic neuralgia due to their impaired cellular immunity and depressed nutritional status...
November 2013: Medical Hypotheses
Arulkumar Nagappan, Hyeon Soo Park, Kwang Il Park, Gyeong Eun Hong, Silvia Yumnam, Ho Jeong Lee, Mun Ki Kim, Eun Hee Kim, Won Sup Lee, Wang Jae Lee, Myung Je Cho, Woo Kon Lee, Chung Kil Won, Jae Hyeon Cho, Gon Sup Kim
Unlike most other mammals, human bodies do not have the ability to synthesize vitamin C inside of their own bodies. Therefore, humans must obtain vitamin C through daily diet. Gulo(-/-) mice strain is known with deficiency, in which vitamin C intake can be controlled by diet like human, and would be valuable for investigating the molecular mechanism of various diseases. In the present study, we established Gulo(-/-) mice model and investigated the differentially expressed proteins in stomach tissue of Gulo(-)(/-) mice after Helicobacter pylori-infected, and followed by DENA, using immunohistochemistry and proteomic approach...
November 25, 2013: Chemico-biological Interactions
Yeong Yeh Lee, Mohammad H Derakhshan
Effective prevention and early diagnostic strategies are the most important public health interventions in gastric cancer, which remains a common malignancy worldwide. Preventive strategies require identification and understanding of environmental risk factors that lead to carcinogenesis. Helicobacter pylori (H. pylori) is the primary carcinogen as this ancient bacterium has a complex ability to interact with its human host. Smoking and salt are strong independent risk factors for gastric cancer whereas alcohol is only a risk when it is heavily consumed...
June 2013: Archives of Iranian Medicine
Tomasz Poplawski, Cezary Chojnacki, Anna Czubatka, Grazyna Klupinska, Jan Chojnacki, Janusz Blasiak
Helicobacter pylori (H. pylori) infection plays an important role in gastric carcinogenesis. This bacterium may induce cancer transformation and change the susceptibility of gastric mucosa cells to various exogenous dietary irritants. The aim of the study was to evaluate the influence of H. pylori infection on the reaction of the stomach cells to a genotoxic effect of heterocyclic amines (HCAs). These well-known mutagens are formed during cooking of protein-rich foods, primarily meat. Taking into account that persons consuming a mixed-western diet are exposed to these compound nearly an entire lifetime and more than half of human population is infected with H...
August 2013: Molecular Biology Reports
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