keyword
https://read.qxmd.com/read/38495192/consumption-of-non-antibacterial-drugs-may-have-negative-impact-on-helicobacter-pylori-colonization-in-the-stomach
#1
JOURNAL ARTICLE
Allah Nazar Atif, Atousa Hatefi, Asadullah Arven, Alireza Foroumadi, Sara Kadkhodaei, Alireza Sadjadi, Farideh Siavoshi
BACKGROUND: Nineteen non-antibacterials were examined to show that their consumption for treatment of other diseases may inhibit Helicobacter pylori . Four antibiotics were used for comparison. MATERIALS AND METHODS: Agar dilution method was used to examine the susceptibility of 20  H. pylori isolates to 4 antibiotics; metronidazole (MTZ), clarithromycin (CLR), amoxicillin (AMX), tetracycline (TET) and 19 non-antibacterials; proton pump inhibitors (PPIs), H2 -blockers, bismuth subsalicylate (BSS), antifungals, statins, acetaminophen (ACE), aspirin (ASA), B-vitamins (B-Vits; Vit B1, Vit B6 and Vit Bcomplex) and vitamin C (Vit C)...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38475712/h-pylori-infection-and-osteoporosis-a-large-scale-observational-and-mendelian-randomization-study
#2
JOURNAL ARTICLE
Ling Zhang, Daya Zhang, Ling Wei, Yan Zhou, Ximei Li, Runxiang Chen, Xiaodong Zhang, Shiju Chen, Feihu Bai
PURPOSE: There is controversy concerning the relationship between Helicobacter pylori (H. pylori) infection and osteoporosis. This study is to examine the causal relationship between H. pylori infection and osteoporosis and to analyze the potential mechanism underlying the relationship. METHODS: The clinical data of H. pylori infection and bone mineral density from patients or physical examiner with good general condition in our hospital between September 2019 and September 2020 were retrospectively collected...
March 12, 2024: BMC Infectious Diseases
https://read.qxmd.com/read/37957555/association-of-serum-vitamin-d-levels-on-helicobacter-pylori-infection-a-retrospective-study-with-real-world-data
#3
JOURNAL ARTICLE
Dan Liu, Li Ren, Dapeng Zhong, Wei Zhang, Wen Wen Li, Jie Liu, Chuan Han
OBJECTIVE: The aim of this study was to determine whether serum vitamin D levels are associated with H. pylori infection and whether low serum vitamin D levels are an independent risk factor for H. pylori infection. METHODS: We conducted a retrospective analysis of a multicenter cohort study from 2017 to 2019. A total of 415 H. pylori+ patients and 257 H. pylori- patients aged between 18 and 75 years with both 13 C-urea breath test and serum vitamin D level results were included from four hospitals...
November 13, 2023: BMC Gastroenterology
https://read.qxmd.com/read/37900161/infection-with-helicobacter-pylori-may-predispose-to-atherosclerosis-role-of-inflammation-and-thickening-of-intima-media-of-carotid-arteries
#4
REVIEW
Karl Aramouni, Roland K Assaf, Maria Azar, Karen Jabbour, Abdullah Shaito, Amirhossein Sahebkar, Assaad A Eid, Manfredi Rizzo, Ali H Eid
Atherosclerosis is a major instigator of cardiovascular disease (CVD) and a main cause of global morbidity and mortality. The high prevalence of CVD calls for urgent attention to possible preventive measures in order to curb its incidence. Traditional risk factors of atherosclerosis, like age, smoking, diabetes mellitus, dyslipidemia, hypertension and chronic inflammation, are under extensive investigation. However, these only account for around 50% of the etiology of atherosclerosis, mandating a search for different or overlooked risk factors...
2023: Frontiers in Pharmacology
https://read.qxmd.com/read/37858436/evaluation-of-the-relationship-between-atherosclerosis-and-helicobacter-pylori-infection-with-measurement-of-growth-differentiation-factor-15-and-atherosclerosis-indicators-in-adults-with-no-comorbidity
#5
JOURNAL ARTICLE
Osman Başpinar, Ayça Elibol, Derya Koçer, Turgut Tursem Tokmak, Serkan Doğan, Oğuzhan Sıtkı Dizdar
BACKGROUND: The aim of this study was to investigate presence of subclinical atherosclerosis by measuring carotid intima-media thickness (CIMT) in patients with Helicobacter pylori (HP) and to assess effects of HP on atherosclerosis by evaluating markers of atherosclerosis and blood growth differentiation factor (GDF-15) levels. MATERIALS AND METHODS: This cross-sectional study included 59 patients without comorbid disease who had HP and 30 healthy controls without HP in upper endoscopic biopsy...
October 17, 2023: Clínica e Investigación en Arteriosclerosis
https://read.qxmd.com/read/37522684/celiac-disease-and-h-pylori-existence-in-the-adult-population-and-its-effects-on-anemia-incidence
#6
JOURNAL ARTICLE
D Tutan, H Köseoğlu, M Sezikli
OBJECTIVE: Anemia is a common extraintestinal symptom of celiac disease; however, inflammation and Helicobacter pylori (HP) infection can also induce anemia. Anemia is associated with both H. pylori infection and celiac disease, which can significantly impact public health. In our study, we aimed to determine the impact of H. pylori infection on anemia in celiac disease adults. PATIENTS AND METHODS: In this study, 150 celiac disease patients with endoscopy results were retrospectively analyzed...
July 2023: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/37329268/chronic-atrophic-gastritis-an-overlooked-association-with-severe-vitamin-b12-deficiency-a-case-report-and-rapid-review-of-literature
#7
JOURNAL ARTICLE
Mahmoud Abosamra, Adrian C Bateman, Mustafa Jalal
The current guidelines recommend surveillance for gastric adenocarcinoma in patients with extensive chronic atrophic gastritis (CAG), which is considered a premalignant condition. A 65-year-old female patient with new onset sensory symptoms was found to have severe vitamin B12 deficiency. She had a normal immunology screen, with negative parietal cell and intrinsic factor antibody titres. Gastroscopy revealed areas of gastric atrophy which was confirmed on biopsy. There was no evidence of Helicobacter pylori in the biopsies...
June 17, 2023: Journal of the Royal College of Physicians of Edinburgh
https://read.qxmd.com/read/36984505/controlling-the-impact-of-helicobacter-pylori-related-hyperhomocysteinemia-on-neurodegeneration
#8
JOURNAL ARTICLE
Jannis Kountouras, Michael Doulberis, Apostolis Papaefthymiou, Stergios A Polyzos, Christos Zavos, Evangelos Kazakos, Stergios Arapoglou, Foteini Kyrailidi, Maria C Mouratidou, Marina Boziki, Elisabeth Vardaka
Helicobacter pylori infection consists a high global burden affecting more than 50% of the world's population. It is implicated, beyond substantiated local gastric pathologies, i.e., peptic ulcers and gastric cancer, in the pathophysiology of several neurodegenerative disorders, mainly by inducing hyperhomocysteinemia-related brain cortical thinning (BCT). BCT has been advocated as a possible biomarker associated with neurodegenerative central nervous system disorders such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, and/or glaucoma, termed as "ocular Alzheimer's disease"...
March 4, 2023: Medicina
https://read.qxmd.com/read/36982855/-helicobacter-pylori-dormant-states-are-affected-by-vitamin-c
#9
JOURNAL ARTICLE
Paola Di Fermo, Silvia Di Lodovico, Emanuela Di Campli, Sara D'Arcangelo, Firas Diban, Simonetta D'Ercole, Mara Di Giulio, Luigina Cellini
Helicobacter pylori colonizes human gastric mucosa, overcoming stressful conditions and entering in a dormant state. This study evaluated: (i) H. pylori 's physiological changes from active to viable-but-non-culturable (VBNC) and persister (AP) states, establishing times/conditions; (ii) the ability of vitamin C to interfere with dormancy generation/resuscitation. A dormant state was induced in clinical MDR H. pylori 10A/13 by: nutrient starvation (for VBNC generation), incubating in an unenriched medium (Brucella broth) or saline solution (SS), and (for AP generation) treatment with 10xMIC amoxicillin (AMX)...
March 17, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/36808372/impact-of-chronic-helicobacter-pylori-infection-on-inflammatory-markers-and-hematological-parameters
#10
JOURNAL ARTICLE
N Ö Sağlam, H A Civan
OBJECTIVE: Determining a non-invasive method for Helicobacter pylori (H. pylori) induced gastritis will be of great help especially in the field of pediatrics. In this study, we aimed to evaluate impact of chronic H. pylori infection on inflammatory markers and hematological parameters. PATIENTS AND METHODS: 522 patients aged between 2 months and 18 years, with chronic dyspeptic complaints who underwent gastroduodenoscopy were included. Complete blood count, ferritin, C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) tests were performed...
February 2023: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/36759293/circulating-proteins-and-metabolite-biomarkers-in-gastric-cancer-a-systematic-review-and-meta-analysis
#11
JOURNAL ARTICLE
Dawei Deng, Yuhan Zhang, Rongzhi Zhang, Jing Yi, Jianli Dong, Liyan Sha, Meiqin Yan
BACKGROUND: Gastric cancer (GC) is often diagnosed at an advanced stage and thus patients have a poor prognosis. This implies that early detection of this cancer will improve patient prognosis and survival. This systematic review explored the association of circulating protein and metabolite biomarkers with GC development. METHODS: A literature search was conducted until November 2021 on Medline, Embase, Cochrane library, and Web of Science databases. Studies were included if they assessed circulating proteins and metabolites in blood, urine, or saliva and determined their association with GC risk...
February 7, 2023: Archives of Medical Research
https://read.qxmd.com/read/36158881/anti-helicobacter-pylori-anti-inflammatory-and-antioxidant-activities-of-trunk-bark-of-alstonia-boonei-apocynaceae
#12
JOURNAL ARTICLE
Zenab Linda Fagni Njoya, Marius Mbiantcha, Stephanie Flore Djuichou Nguemnang, Vanessa Mba Matah Marthe, William Yousseu Nana, Yacine Karelle Madjo Kouam, Elvira Ngoufack Azanze, Eric Gonzal Tsafack, Gilbert Ateufack
An ulcer is an erosion of the gastric mucosa that occurs following an imbalance between the aggression and protective factors and/or an infection with Helicobacter pylori ( H. pylori ). About 90-100% of duodenal ulcers and 70-80% of gastric ulcers are caused by H. pylori . The objective of this work was to evaluate in vitro the anti- H. pylori activity and then the anti-inflammatory and antioxidant properties of aqueous and methanol extracts of Alstonia boonei . The anti- H. pylori tests (CMI and antiureasic activity) were determined using the agar well diffusion method, the microbroth dilution method, and the measurement of ammonia production by the indophenol method; the anti-inflammatory properties were evaluated by inhibition of proteinases, denaturation of albumin, production of NO by macrophages, cell viability, and hemolysis of red blood cells by heat; then, the antioxidant properties were evaluated by the FRAP method (ferric reducing antioxidant power) and the DPPH (1,1-diphenyl-2-picrylhydrazyl) test...
2022: BioMed Research International
https://read.qxmd.com/read/35587225/1%C3%AE-25-dihydroxyvitamin-d3-protects-gastric-mucosa-epithelial-cells-against-helicobacter-pylori-infected-apoptosis-through-a-vitamin-d-receptor-dependent-c-raf-mek-erk-pathway
#13
JOURNAL ARTICLE
Shuai Zhao, Daihong Wan, Yaoyao Zhong, Xiwei Xu
CONTEXT: Due to the resistance of Helicobacter pylori to antibiotics, it is difficult to eradicate this pathogenic bacterium from the host. The role of 1α, 25-dihydroxyvitamin D3 (1,25-D3) in H. pylori -infected gastric mucosa epithelial cells remains unknown. OBJECTIVE: This study investigates the protective property of 1,25-D3 against H. pylori -infected apoptosis in gastric mucosa epithelial cells and its potential molecular mechanisms. MATERIALS AND METHODS: GES-1 cells were infected with H...
December 2022: Pharmaceutical Biology
https://read.qxmd.com/read/35135310/effectiveness-of-ivermectin-based-multidrug-therapy-in-severely-hypoxic-ambulatory-covid-19-patients
#14
JOURNAL ARTICLE
Sabine Hazan, Sonya Dave, Anoja W Gunaratne, Sibasish Dolai, Robert L Clancy, Peter A McCullough, Thomas J Borody
Aims: Ivermectin is a safe, inexpensive and effective early COVID-19 treatment validated in 20+ random, controlled trials. Having developed combination therapies for Helicobacter pylori , the authors present a highly effective COVID-19 therapeutic combination, stemming from clinical observations. Patients & methods: In 24 COVID-19 subjects refusing hospitalization with high-risk features, hypoxia and untreated moderate to severe symptoms averaging 9 days, the authors administered this novel combination of ivermectin, doxycycline, zinc and vitamins D and C...
March 2022: Future Microbiology
https://read.qxmd.com/read/34484423/autoimmune-gastritis-with-or-without-pernicious-anemia-epidemiology-risk-factors-and-clinical-management
#15
REVIEW
Sheila D Rustgi, Priyesha Bijlani, Shailja C Shah
Autoimmune gastritis (AIG) is a chronic immune-mediated, inflammatory condition that involves the destruction of the gastric oxyntic mucosa through the autoimmune-mediated loss of parietal cells, with replacement by atrophic and metaplastic tissue. Diagnosing AIG is important, given the need for ongoing clinical management and vigilance with respect to downstream complications, the most serious of which is gastric adenocarcinoma. Other clinical consequences include gastric neuroendocrine tumors, consequences related to decreased gastric acid and decreased intrinsic factor due to parietal cell destruction and antibodies against intrinsic factor (e...
2021: Therapeutic Advances in Gastroenterology
https://read.qxmd.com/read/34454714/aga-clinical-practice-update-on-the-diagnosis-and-management-of-atrophic-gastritis-expert-review
#16
REVIEW
Shailja C Shah, M Blanca Piazuelo, Ernst J Kuipers, Dan Li
DESCRIPTION: The purpose of this Clinical Practice Update Expert Review is to provide clinicians with guidance on the diagnosis and management of atrophic gastritis, a common preneoplastic condition of the stomach, with a primary focus on atrophic gastritis due to chronic Helicobacter pylori infection-the most common etiology-or due to autoimmunity. To date, clinical guidance for best practices related to the diagnosis and management of atrophic gastritis remains very limited in the United States, which leads to poor recognition of this preneoplastic condition and suboptimal risk stratification...
October 2021: Gastroenterology
https://read.qxmd.com/read/33919894/vegetable-extracts-and-nutrients-useful-in-the-recovery-from-helicobacter-pylori-infection-a-systematic-review-on-clinical-trials
#17
REVIEW
Hammad Ullah, Alessandro Di Minno, Cristina Santarcangelo, Haroon Khan, Jianbo Xiao, Carla Renata Arciola, Maria Daglia
Helicobacter pylori ( H. pylori ) infections affect almost half of the world's population, with gradually increasing incidence in developed countries. Eradication of H. pylori may provide significant benefits to the affected individual by healing a number of gastrointestinal and extra-digestive disorders. But due to increased microbial resistance and lack of patient adherence to the therapy, the eradication rate of H. pylori is below 80% with current pharmacological therapies. The usage of botanicals for their therapeutic purposes and medicinal properties have been increased in last decades...
April 14, 2021: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/33649116/spot-mediated-napa-upregulation-promotes-oxidative-stress-induced-helicobacter-pylori-biofilm-formation-and-confers-multidrug-resistance
#18
JOURNAL ARTICLE
Yican Zhao, Yuying Cai, Zhenghong Chen, Huanjie Li, Zhengzheng Xu, Wenjuan Li, Jihui Jia, Yundong Sun
Recently, there is increased incidence of drug-resistant Helicobacter pylori infection. Biofilm formation confers multidrug resistance to bacteria. Moreover, it has been found that the formation of biofilm on the surface of gastric mucosa is an important reason for the difficulty of eradication of H. pylori The mechanisms underlying H. pylori biofilm formation in vivo have not been elucidated. Reactive oxygen species (ROS) released by the host immune cells in response to H. pylori infection cannot effectively clear the pathogen...
March 1, 2021: Antimicrobial Agents and Chemotherapy
https://read.qxmd.com/read/33292344/validation-of-dietary-antioxidant-index-dai-and-investigating-the-relationship-between-dai-and-the-odds-of-gastric-cancer
#19
JOURNAL ARTICLE
Farhad Vahid, Diana Rahmani, Seyed Hossein Davoodi
BACKGROUND: Gastric cancer (GC) incidence and mortality are rapidly growing worldwide. It is estimated that more than 1,000,000 new cases are diagnosed each year, and more than 78,000 people lose their lives due to GC. The association between dietary antioxidants and GC has been shown in some studies. However, because of the discrepancy between the findings and the lack of a valid indicator, it seems necessary to design and validate the Dietary Antioxidant Index (DAI) to examine the diet's total antioxidant content...
December 1, 2020: Nutrition & Metabolism
https://read.qxmd.com/read/33197219/the-spectrum-of-helicobacter-mediated-diseases
#20
REVIEW
Karen Robinson, John C Atherton
Helicobacter pylori is the leading cause of peptic ulcer disease. The infection has been implicated in more than 75% of duodenal ulcer cases and 17% of gastric ulcer cases. H. pylori has been classified as a human carcinogen, since it is the main cause of distal gastric adenocarcinoma and B cell mucosa-associated lymphoid tissue lymphoma. Evidence also links H. pylori with extragastric conditions including iron deficiency anemia, idiopathic thrombocytopenic purpura, and vitamin B12 deficiency. Studies indicate that H...
January 24, 2021: Annual Review of Pathology
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