Zenab Linda Fagni Njoya, Marius Mbiantcha, Stephanie Flore Djuichou Nguemnang, Vanessa Mba Matah Marthe, William Yousseu Nana, Yacine Karelle Madjo Kouam, Elvira Ngoufack Azanze, Eric Gonzal Tsafack, Gilbert Ateufack
An ulcer is an erosion of the gastric mucosa that occurs following an imbalance between the aggression and protective factors and/or an infection with Helicobacter pylori ( H. pylori ). About 90-100% of duodenal ulcers and 70-80% of gastric ulcers are caused by H. pylori . The objective of this work was to evaluate in vitro the anti- H. pylori activity and then the anti-inflammatory and antioxidant properties of aqueous and methanol extracts of Alstonia boonei . The anti- H. pylori tests (CMI and antiureasic activity) were determined using the agar well diffusion method, the microbroth dilution method, and the measurement of ammonia production by the indophenol method; the anti-inflammatory properties were evaluated by inhibition of proteinases, denaturation of albumin, production of NO by macrophages, cell viability, and hemolysis of red blood cells by heat; then, the antioxidant properties were evaluated by the FRAP method (ferric reducing antioxidant power) and the DPPH (1,1-diphenyl-2-picrylhydrazyl) test...
2022: BioMed Research International