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https://www.readbyqxmd.com/read/28651357/using-viral-gene-sequences-to-compare-and-explain-the-heterogeneous-spatial-dynamics-of-virus-epidemics
#1
Simon Dellicour, Rebecca Rose, Nuno Rodrigues Faria, Luiz Fernando Pereira Vieira, Hervé Bourhy, Marius Gilbert, Philippe Lemey, Oliver G Pybus
Rabies is an important zoonotic disease distributed worldwide. A key question in rabies epidemiology is the identification of factors that impact virus dispersion. Here we apply new analytical methods, based on phylogeographic reconstructions of viral lineage movement, to undertake a comparative evolutionary-epidemiological study of the spatial dynamics of rabies virus (RABV) epidemics in different hosts and habitats. We have compiled RABV data sets from skunk, raccoon, bat and domestic dog populations in order to investigate the viral diffusivity of different RABV epidemics, and detect and compare those environmental factors that impact the velocity of viral spread in continuous spatial landscapes...
June 23, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/28649604/combined-immunotherapy-with-anti-insulin-resistance-therapy-as-a-novel-therapeutic-strategy-against-neurodegenerative-diseases
#2
Yoshiki Takamatsu, Gilbert Ho, Wakako Koike, Shuei Sugama, Takato Takenouchi, Masaaki Waragai, Jianshe Wei, Kazunari Sekiyama, Makoto Hashimoto
Protein aggregation is a pathological hallmark of and may play a central role in the neurotoxicity in age-associated neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. Accordingly, inhibiting aggregation of amyloidogenic proteins, including amyloid β and α-synuclein, has been a main therapeutic target for these disorders. Among various strategies, amyloid β immunotherapy has been extensively investigated in Alzheimer's disease, followed by similar studies of α-synuclein in Parkinson's disease...
2017: NPJ Parkinson's Disease
https://www.readbyqxmd.com/read/28649467/larval-exposure-to-field-realistic-concentrations-of-clothianidin-has-no-effect-on-development-rate-over-winter-survival-or-adult-metabolic-rate-in-a-solitary-bee-osmia-bicornis
#3
Elizabeth Nicholls, Robert Fowler, Jeremy E Niven, James D Gilbert, Dave Goulson
There is widespread concern regarding the effects of agro-chemical exposure on bee health, of which neonicotinoids, systemic insecticides detected in the pollen and nectar of both crops and wildflowers, have been the most strongly debated. The majority of studies examining the effect of neonicotinoids on bees have focussed on social species, namely honey bees and bumble bees. However, most bee species are solitary, their life histories differing considerably from these social species, and thus it is possible that their susceptibility to pesticides may be quite different...
2017: PeerJ
https://www.readbyqxmd.com/read/28648558/potential-drug-targets-in-small-bowel-adenocarcinoma
#4
Judith A Gilbert
No abstract text is available yet for this article.
June 22, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28648546/process-intensification-for-high-yield-production-of-influenza-h1n1-gag-virus-like-particles-using-an-inducible-hek-293-stable-cell-line
#5
Alina Venereo-Sanchez, Melanie Simoneau, Stéphane Lanthier, Parminder Chahal, Lucie Bourget, Sven Ansorge, Rénald Gilbert, Olivier Henry, Amine Kamen
Influenza virus dominant antigens presentation using virus like particle (VLP) approach is attractive for the development of new generation of influenza vaccines. Mammalian cell platform offers many advantages for VLP production. However, limited attention has been paid to the processing of mammalian cell produced VLPs. Better understanding of the production system could contribute to increasing the yields and making large-scale VLP vaccine manufacturing feasible. In a previous study, we have generated a human embryonic kidney HEK-293 inducible cell line expressing Hemagglutinin (HA) and Neuraminidase (NA), which was used to produce VLPs upon transient transfection with a plasmid containing HIV-1 Gag...
June 22, 2017: Vaccine
https://www.readbyqxmd.com/read/28647245/transport-and-humification-of-dissolved-organic-matter-within-a-semi-arid-floodplain
#6
Wenming Dong, Jiamin Wan, Tetsu K Tokunaga, Benjamin Gilbert, Kenneth H Williams
In order to understand the transport and humification processes of dissolved organic matter (DOM) within sediments of a semi-arid floodplain at Rifle, Colorado, fluorescence excitation-emission matrix (EEM) spectroscopy, humification index (HIX) and specific UV absorbance (SUVA) at 254nm were applied for characterizing depth and seasonal variations of DOM composition. Results revealed that late spring snowmelt leached relatively fresh DOM from plant residue and soil organic matter down into the deeper vadose zone (VZ)...
July 2017: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/28646365/post-diagnosis-serum-insulin-like-growth-factors-in-relation-to-dietary-and-lifestyle-changes-in-the-prostate-testing-for-cancer-and-treatment-protect-trial
#7
Vanessa Er, Kalina Biernacka, Andrew J Simpkin, Richard M Martin, Mona Jeffreys, Pauline Emmett, Rebecca Gilbert, Kerry N L Avery, Eleanor Walsh, Michael Davis, Jenny L Donovan, David E Neal, Freddie C Hamdy, Jeff M P Holly, J Athene Lane
PURPOSE: The insulin-like growth factor (IGF) system is modifiable by diet and lifestyle, and has been linked to prostate cancer development and progression. METHODS: We conducted a prospective cohort study of 621 men diagnosed with localized prostate cancer to investigate the associations of dietary and lifestyle changes with post-diagnosis circulating levels of IGF-I and IGFBP-3. We used analysis of covariance to estimate the associations, controlling for baseline IGF-I or IGFBP-3, respectively...
June 23, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28646326/transposable-elements-mediate-adaptive-debilitation-of-flagella-in-experimental-escherichia-coli-populations
#8
Gordon R Plague, Krystal S Boodram, Kevin M Dougherty, Sandar Bregg, Daniel P Gilbert, Hira Bakshi, Daniel Costa
Although insertion sequence (IS) elements are generally considered genomic parasites, they can mediate adaptive genetic changes in bacterial genomes. We discovered that among 12 laboratory-evolved Escherichia coli populations, three had experienced at least six different IS1-mediated deletions of flagellar genes. These deletions all involved the master flagellar regulator flhDC, and as such completely incapacitate motility. Two lines of evidence strongly suggest that these deletions were adaptive in our evolution experiment: (1) parallel evolution in three independent populations is highly unlikely just by chance, and (2) one of these deletion mutations swept to fixation within ~1000 generations, which is over two million times faster than expected if this deletion was instead selectively neutral and thus evolving by genetic drift...
June 23, 2017: Journal of Molecular Evolution
https://www.readbyqxmd.com/read/28645769/access-to-preventive-services-for-working-age-adults-with-physical-limitations
#9
Gilbert Gimm, Elizabeth Wood, Preeti Zanwar
OBJECTIVE: To examine differences in access to preventive services for working-age adults with physical limitations, non-physical limitations, and no limitations. DESIGN: Observational data were pooled across calendar years 2003-2012 from the Medical Expenditure Panel Survey (MEPS), a nationally representative survey of non-institutionalized U.S. adults. SETTING: Community. PARTICIPANTS: Working-age adults (18-64 years of age) who responded to all five rounds in MEPS during 2003 through 2012...
June 20, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28644416/evaluation-of-trace-element-and-metal-accumulation-and-edibility-risk-associated-with-consumption-of-labeo-umbratus-from-the-vaal-dam-south-africa
#10
Beric M Gilbert, Ebrahim Hussain, Franz Jirsa, Annemariè Avenant-Oldewage
With the occurrence of recreational and small scale subsistence fishing activities at the Vaal Dam, South Africa, consumption of fish from this dam may result in health risks associated with trace elements and metals. The Vaal Dam is one of the largest dams in South Africa, located between the Gauteng Province and Orange Free State, and supplies water to approximately 11.6 million people. A total of 38 specimens of the benthic cyprinid fish Labeo umbratus were collected from the Vaal Dam during two surveys, in 2011 and 2016...
June 23, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28643447/simultaneous-mapping-of-metabolites-and-individual-macromolecular-components-via-ultra-short-acquisition-delay-1-h-mrsi-in-the-brain-at-7t
#11
Michal Považan, Bernhard Strasser, Gilbert Hangel, Eva Heckova, Stephan Gruber, Siegfried Trattnig, Wolfgang Bogner
PURPOSE: Short-echo-time proton MR spectra at 7T feature nine to 10 distinct macromolecule (MM) resonances that overlap with the signals of metabolites. Typically, a metabolite-nulled in vivo MM spectrum is included in the quantification`s prior knowledge to provide unbiased metabolite quantification. However, this MM model may fail if MMs are pathologically altered. In addition, information about the individual MM peaks is lost. In this study, we aimed to create an improved MM model by parameterization of the in vivo MM spectrum into individual components, and to use this new model to quantify free induction decay MR spectroscopic imaging (FID-MRSI) data...
June 22, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28643100/perceived-devaluation-and-sti-testing-uptake-among-a-cohort-of-street-involved-youth-in-a-canadian-setting
#12
Mohammad Karamouzian, Jean Shoveller, Huiru Dong, Mark Gilbert, Thomas Kerr, Kora DeBeck
Perceived devaluation has been shown to have adverse effects on the mental and physical health outcomes of people who use drugs. However, the impact of perceived devaluation on sexually transmitted infections (STI) testing uptake among street-involved youth, who face multiple and intersecting stigmas due to their association with drug use and risky sexual practices, has not been fully characterized. Data were obtained between December 2013 and November 2014 from a cohort of street-involved youth who use illicit drugs aged 14-26 in Vancouver, British Columbia...
June 22, 2017: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/28642290/coronary-events-complicating-infective-endocarditis
#13
Virginie Roux, Erwan Salaun, Christophe Tribouilloy, Sandrine Hubert, Yohann Bohbot, Jean-Paul Casalta, Pierre-Antoine Barral, Dan Rusinaru, Frederique Gouriet, Cecile Lavoute, Julie Haentjens, Mathieu Di Biscegli, Aurelie Dehaene, Sebastien Renard, Anne-Claire Casalta, Julie Pradier, Jean-Francois Avierinos, Alberto Riberi, Marc Lambert, Frederic Collart, Alexis Jacquier, Franck Thuny, Laurence Camoin-Jau, Hubert Lepidi, Didier Raoult, Gilbert Habib
OBJECTIVE: Acute coronary syndromes (ACS) are a rare complication of infective endocarditis (IE). Only case reports and small studies have been published to date. We report the largest series of ACS in IE. The aim of our study was to describe the incidence and mechanisms of ACS associated with IE, to assess their prognostic impact and to describe their management. METHODS: In a bicentre prospective observational cohort study, all patients with a definite diagnosis of IE were prospectively included...
June 22, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28642154/a-boosting-skin-vaccination-with-dissolving-microneedle-patch-encapsulating-m2e-vaccine-broadens-the-protective-efficacy-of-conventional-influenza-vaccines
#14
Wandi Zhu, Winston Pewin, Chao Wang, Yuan Luo, Gilbert X Gonzalez, Teena Mohan, Mark R Prausnitz, Bao-Zhong Wang
The biodegradable microneedle patch (MNP) is a novel technology for vaccine delivery that could improve the immunogenicity of vaccines. To broaden the protective efficiency of conventional influenza vaccines, a new 4M2e-tFliC fusion protein construct containing M2e sequences from different subtypes was generated. Purified fusion protein was encapsulate into MNPs with a biocompatible polymer for use as a boosting vaccine. The results demonstrated that mice receiving a conventional inactivated vaccine followed by a skin-applied dissolving 4M2e-tFliC MNP boost could better maintain the humoral antibody response than that by the conventional vaccine-prime alone...
June 19, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28641314/no-additional-prognostic-value-for-mre11-in-squamous-cell-carcinomas-of-the-anus-treated-with-chemo-radiotherapy
#15
Alexandra K Walker, Christiana Kartsonaki, Elena Collantes, Judith Nicholson, Duncan C Gilbert, Anne E Kiltie
BACKGROUND: The majority of anal cancers (84-95%) are driven by infection with human papillomavirus (HPV). HPV-positive tumours show significantly better responses to chemo-radiotherapy when compared with HPV-negative tumours. HPV infection is linked to alterations in DNA damage response proteins, including MRE11. MRE11 is a potential predictive biomarker for response to radiotherapy in muscle-invasive bladder cancer and may hold predictive power in other cancers. METHODS: Using a previously reported cohort, we evaluated the levels of MRE11 in anal cancer and assessed its predictive value in this disease...
June 22, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28639611/masked-hypertension-and-effort-reward-imbalance-at-work-among-2369-white-collar-workers
#16
P Boucher, M Gilbert-Ouimet, X Trudel, C S Duchaine, A Milot, C Brisson
Hypertension is an important risk factor of cardiovascular diseases, the leading cause of death worldwide. Adverse effects of psychosocial factors at work might increase the risk of masked hypertension, but evidences are still scarce. The objective of this study is then to determine whether adverse psychosocial work factors from the effort-reward imbalance (ERI) model are associated with the prevalence of masked hypertension in a population of white-collar workers. White-collar workers were recruited from three public organizations...
June 22, 2017: Journal of Human Hypertension
https://www.readbyqxmd.com/read/28638728/gene-expression-analysis-in-cutaneous-t-cell-lymphomas-ctcl-highlights-disease-heterogeneity-and-potential-diagnostic-and-prognostic-indicators
#17
Ivan V Litvinov, Michael T Tetzlaff, Philippe Thibault, Pamela Gangar, Linda Moreau, Andrew K Watters, Elena Netchiporouk, Kevin Pehr, Victor G Prieto, Elham Rahme, Nathalie Provost, Martin Gilbert, Denis Sasseville, Madeleine Duvic
Cutaneous T-Cell Lymphomas (CTCL) are rare, but potentially devastating malignancies, whose pathogenesis remains poorly elucidated. Unfortunately, currently it is not possible to predict based on the available criteria in which patients the cancer will progress and which patients will experience an indolent disease course. Furthermore, at early stages this malignancy often masquerades as psoriasis, chronic eczema or other benign inflammatory dermatoses. As a result, it takes on average 6 y to diagnose this lymphoma since its initial presentation...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28638607/course-of-chronic-kidney-disease-in-french-patients
#18
Nicolas Janus, Vincent Launay-Vacher, Laurent Juillard, Gilbert Deray, Thierry Hannedouche, Myriam Isnard-Rouchon, Stéphane Burtey, Philippe Vanhille, Jean-Paul Ortiz, Gérard Janin, Philippe Nicoud, Malik Touam, Maurice Laville
BACKGROUND: In 1998, a French survey showed that the referral of patients with chronic kidney disease to a nephrologist was delayed, resulting in many emergency initiations of dialysis. In 2009, the ORACLE study aimed to describe the renal course of dialysis patients from their first nephrology visit to their first dialysis session. METHODS: The ORACLE study was a multicentre retrospective study of all patients who started chronic dialysis. Data were collected at the first nephrology visit and at the first dialysis session...
February 2017: Clinical Kidney Journal
https://www.readbyqxmd.com/read/28638371/the-anticancer-peptide-tat-rasgap317-326-exerts-broad-antimicrobial-activity
#19
Mathieu Heulot, Nicolas Jacquier, Sébastien Aeby, Didier Le Roy, Thierry Roger, Evgeniya Trofimenko, David Barras, Gilbert Greub, Christian Widmann
Antibiotic resistance has become a major health issue. Nosocomial infections and the prevalence of resistant pathogenic bacterial strains are rising steadily. Therefore, there is an urgent need to develop new classes of antibiotics effective on multi-resistant nosocomial pathogenic bacteria. We have previously shown that a cell-permeable peptide derived from the p120 Ras GTPase-activating protein (RasGAP), called TAT-RasGAP317-326, induces cancer cell death, inhibits metastatic progression, and sensitizes tumor cells to various anti-cancer treatments in vitro and in vivo...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28637865/an-evolutionarily-distinct-family-of-polysaccharide-lyases-removes-rhamnose-capping-of-complex-arabinogalactan-proteins
#20
José Munoz-Munoz, Alan Cartmell, Nicolas Terrapon, Arnaud Baslé, Bernard Henrissat, Harry J Gilbert
The human gut microbiota utilizes complex carbohydrates as major nutrients. The requirement for efficient glycan degrading systems exerts a major selective selection pressure on this microbial community. Thus, we propose that this microbial ecosystem represents a substantial resource for discovering novel carbohydrate active enzymes. To test this hypothesis we screened the potential enzymatic functions of hypothetical proteins encoded by genes of Bacteroides thetaiotaomicron that were upregulated by arabinogalactan arabinogalactan proteins or AGPs...
June 21, 2017: Journal of Biological Chemistry
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