Tae Min Kim, Dong-Wan Kim, Yoon-Koo Kang, Jooseop Chung, Hong-Suk Song, Hyo Jung Kim, Byung Soo Kim, Jong-Seok Lee, Hawk Kim, Sung Hyun Yang, Young Jin Yuh, Sung Hwa Bae, Myung Soo Hyun, Yoon Kyung Jeon, Chul Woo Kim, Dae Seog Heo
BACKGROUND: Combination chemotherapy consisting of ifosfamide, methotrexate, etoposide, and prednisolone (IMEP) was active as first-line and second-line treatment for extranodal natural killer/T-cell lymphoma (NTCL). METHODS: Forty-four patients with chemo-naïve stage I/II NTCL were enrolled in a prospective, multicenter, phase II study and received six cycles of IMEP (ifosfamide 1.5 g/m(2) on days 1-3; methotrextate 30 mg/m(2) on days 3 and 10; etoposide 100 mg/m(2) on days 1-3; and prednisolone 60 mg/m(2) per day on days 1-5) followed by involved field radiotherapy (IFRT)...
November 2014: Oncologist