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Systemic lupus erythematosus

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https://www.readbyqxmd.com/read/30024540/association-of-serum-plasma-high-mobility-group-box-1-with-autoimmune-diseases-a-systematic-review-and-meta-analysis
#1
Bin Zhu, Qing Zhu, Nanfang Li, Ting Wu, Shasha Liu, Shanshan Liu
BACKGROUND: High mobility group box 1 (HMGB1) is a kind of proinflammatory mediator to stimulate the innate and adaptive immune system and participates in a number of acute and chronic inflammatory processes after sterile injury or microbial invasion. HMGB1 has been suggested to be involved in the pathogenesis of many autoimmune diseases. However, the results are contradictory or inconclusive among these findings. The aim of this study was to investigate whether serum/plasma HMGB1 levels are associated with autoimmune diseases by comparing the serum/plasma HMGB1 levels in patients with autoimmune disease and healthy controls and to further evaluate whether serum/plasma HMGB1 levels are associated with disease state...
July 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30021804/photosensitivity-and-type-i-ifn-responses-in-cutaneous-lupus-are-driven-by-epidermal-derived-interferon-kappa
#2
Mrinal K Sarkar, Grace A Hile, Lam C Tsoi, Xianying Xing, Jianhua Liu, Yun Liang, Celine C Berthier, William R Swindell, Matthew T Patrick, Shuai Shao, Pei-Suen Tsou, Ranjitha Uppala, Maria A Beamer, Anshika Srivastava, Stephanie L Bielas, Paul W Harms, Spiro Getsios, James T Elder, John J Voorhees, Johann E Gudjonsson, J Michelle Kahlenberg
OBJECTIVE: Skin inflammation and photosensitivity are common in patients with cutaneous lupus erythematosus (CLE) and systemic lupus erythematosus (SLE), yet little is known about the mechanisms that regulate these traits. Here we investigate the role of interferon kappa (IFN-κ) in regulation of type I interferon (IFN) and photosensitive responses and examine its dysregulation in lupus skin. METHODS: mRNA expression of type I IFN genes was analysed from microarray data of CLE lesions and healthy control skin...
July 18, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/30021765/cutting-edge-deletion-of-ezrin-in-b-cells-of-lyn-deficient-mice-downregulates-lupus-pathology
#3
Debasis Pore, Emily Huang, Dina Dejanovic, Neetha Parameswaran, Michael B Cheung, Neetu Gupta
Genetic deletion of the Src family tyrosine kinase Lyn in mice recapitulates human systemic lupus erythematosus, characterized by hyperactive BCR signaling, splenomegaly, autoantibody generation, and glomerulonephritis. However, the molecular regulators of autoimmunity in Lyn-deficient mice and in human lupus remain poorly characterized. In this study, we report that conditional deletion of the membrane-cytoskeleton linker protein ezrin in B cells of Lyn-deficient mice (double knockout [DKO] mice) ameliorates B cell activation and lupus pathogenesis...
July 18, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/30021694/idiopathic-immune-complex-mediated-tubulointerstitial-nephritis-with-hypocomplementemia-and-neutrophil-rich-interstitial-infiltrates
#4
Haruka Ikuta, Jaegi Shim, Masahiro Takahashi, Mitsuteru Koizumi, Koichi Seta, Shigeo Hara, Kensei Yahata
A 69-year-old man presented with acute kidney injury, hypocomplementemia, antinuclear antibody, and anti-dsDNA antibody. He had no signs of systemic lupus erythematosus or Sjögren syndrome. He had not begun taking any new drugs in the preceding 6 months. Kidney biopsy revealed 13 glomeruli, 3 with global sclerosis. The remaining glomeruli showed slight mesangial proliferation. The interstitial inflammation was extensive, comprising mainly mature lymphocytes and plasma cells, neutrophils, and a few eosinophils...
July 19, 2018: Clinical Nephrology
https://www.readbyqxmd.com/read/30020023/characteristics-of-1555-childhood-onset-lupus-in-three-groups-based-on-distinct-time-intervals-to-disease-diagnosis-a-brazilian-multicenter-study
#5
G V Novak, B C Molinari, J C Ferreira, A P Sakamoto, M T Terreri, R M R Pereira, C Saad-Magalhães, N E Aikawa, L M Campos, C A Len, S Appenzeller, V P Ferriani, M F Silva, S K Oliveira, A G Islabão, F R Sztajnbok, L B Paim, C M Barbosa, M C Santos, B E Bica, E G Sena, A J Moraes, A M Rolim, P F Spelling, I M Scheibel, A S Cavalcanti, E N Matos, T C Robazzi, L J Guimarães, F P Santos, C T Silva, E Bonfá, C A Silva
Objective The objective of this study was to compare demographic data, clinical/laboratorial features and disease activity at diagnosis in three different groups with distinct time intervals between onset of signs/symptoms and disease diagnosis. Methods A multicenter study was performed in 1555 childhood-onset systemic lupus erythematosus (American College of Rheumatology criteria) patients from 27 pediatric rheumatology services. Patients were divided into three childhood-onset systemic lupus erythematosus groups: A: short time interval to diagnosis (<1 month); B: intermediate time interval (≥1 and <3 months); and C: long time interval (≥3 months)...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/30020022/prognostic-nutritional-index-is-correlated-with-disease-activity-in-patients-with-systemic-lupus-erythematosus
#6
S S Ahn, S M Jung, J J Song, Y-B Park, S-W Lee
The prognostic nutritional index (PNI), which is calculated using serum albumin level and total lymphocyte count in the peripheral blood, is regarded as an index that reflects the immunonutritional status of patients. PNI was calculated in 217 systemic lupus erythematosus (SLE) patients according to the following formula: 10 × serum albumin value (g/dL) + 0.005 × peripheral lymphocyte count (/mm3 ). Pearson's correlation analysis was used to elucidate the correlation between continuous variables...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/30020020/medical-adherence-in-patients-with-systemic-lupus-erythematosus-in-germany-predictors-and-reasons-for-non-adherence-a-cross-sectional-analysis-of-the-lula-cohort
#7
G Chehab, G M Sauer, J G Richter, R Brinks, R Willers, R Fischer-Betz, B Winkler-Rohlfing, M Schneider
Objective Adherence to medication has a major impact on treatment control and success especially in chronic diseases but often remains unrecognized. Besides clinical, socioeconomic, disease-related and treatment-related parameters, general and personal health beliefs, as well as perception of health, can affect adherence. Our aim was to investigate the adherence to lupus-specific medications in German lupus patients and to assess influencing factors including detrimental or beneficial effects of health perceptions and beliefs...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/30019710/an-electrochemical-biosensor-for-rapid-detection-of-anti-dsdna-antibodies-in-absolute-scale
#8
Pablo Fagúndez, Gustavo Brañas, Ernesto Cairoli, Justo Laíz, Juan Pablo Tosar
Autoimmune diseases are chronic inflammatory pathologies that are characterized by the presence of antibodies against the body's own epitopes in serum (autoantibodies). Systemic lupus erythematosus (SLE) is a common autoimmune pathology characterized by the presence of antinuclear antibodies (ANAs). These include anti-dsDNA (α-dsDNA) antibodies, which are widely used for diagnosis and disease monitoring. Their determination is carried out using traditional techniques such as Indirect Immunofluorescence (IFI) or Enzyme-Linked Immunosorbent Assay (ELISA), which are time consuming, require qualified technicians, and are not compatible with decentralized analysis outside a laboratory facility...
July 18, 2018: Analyst
https://www.readbyqxmd.com/read/30018955/the-role-of-long-non-coding-rnas-in-the-pathogenesis-of-ra-sle-and-ss
#9
Yunzhen Gao, Shasha Li, Zhongjian Zhang, Xinhua Yu, Junfeng Zheng
Rheumatoid diseases are a group of systemic autoimmune diseases which affect multiple organs with largely unknown etiology. In the past decade, long non-coding RNAs (lncRNAs) have emerged as important regulators of biological processes and contribute deeply to immune cell development and immune responses. Substantial evidences have been accumulated showing that LncRNAs involved in the pathogenesis of the rheumatoid diseases, including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS)...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/30017673/a-comprehensive-review-of-immune-mediated-dermatopathology-in-systemic-lupus-erythematosus
#10
REVIEW
Qianwen Li, Haijing Wu, Wei Liao, Ming Zhao, Vera Chan, Linfeng Li, Min Zheng, Genhui Chen, Jianzhong Zhang, Chak-Sing Lau, Qianjin Lu
Lupus erythematosus (LE) is an autoimmune disease with a broad clinical spectrum ranging from cutaneous lesions to severe systemic manifestations. The pathogenesis of the disease and the immunological mechanisms for the heterogeneities in lupus remain unclear. The LE-specific cutaneous manifestations are generally divided into three categories: acute cutaneous LE (ACLE), subacute cutaneous LE (SCLE) and chronic cutaneous lupus erythematosus (CCLE). Clinically, lupus patients with skin lesions can be divided into two subsets based on the organs involved: cutaneous LE, such as DLE and SCLE, which appears only as a skin manifestation, and systemic lupus erythematosus (SLE), e...
July 11, 2018: Journal of Autoimmunity
https://www.readbyqxmd.com/read/30016937/immunoglobulin-induced-aseptic-meningitis-a-case-report
#11
Luísa Graça, Joana Alves, João Nuak, António Sarmento
BACKGROUND: Immunoglobulin associated meningitis is a rare disease that mimics infectious meningitis. This is, to our knowledge, the first case of Immunoglobulin-associated meningitis described in a patient with Systemic Lupus Erythematosus and hypogammaglobulinemia secondary to Rituximab. CASE PRESENTATION: A 46-year-old female with a past medical history of Systemic Lupus Erythematosus, presented with meningismus 36 h after first infusion of intravenous immunoglobulin...
July 17, 2018: BMC Neurology
https://www.readbyqxmd.com/read/30016928/sle-mortality-remains-disproportionately-high-despite-improvements-over-the-last-decade
#12
R R Singh, E Y Yen
Despite a marked improvement in 10-year survival for systemic lupus erythematosus (SLE) patients over the past five decades, mortality rates from SLE remain high compared to those in the general population. SLE was also among the leading causes of death in young women in the United States during 2000-2015. However, it is encouraging that SLE mortality rates and the ratios of SLE mortality rates to non-SLE mortality rates have decreased every year since the late 1990s. Despite this improvement, disparities in SLE mortality persist according to sex, race, age, and place of residence...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/30016488/atherosclerosis-and-renal-disease-involvement-in-patients-with-systemic-lupus-erythematosus-a-cross-sectional-cohort-study
#13
Marie-Louise Hermansen, Benjamin Sandholt, Andreas Fuchs, Henrik Sillesen, Lars Køber, Klaus Fuglsang Kofoed, Mikkel Faurschou, Søren Jacobsen
Objective: To investigate the association between LN, renal function and atherosclerosis measured by coronary artery calcium (CAC) and carotid plaque in a cross-sectional study of patients with SLE. Methods: Presence of CAC and carotid plaque was measured in 147 SLE patients with and without LN. The patients were divided into four groups according to LN and renal function [by first quartile of estimated glomerular filtration rate (eGFR): 70 ml/min/1.73 m2]. Impaired renal function was defined by an eGFR <70 ml/min/1...
July 16, 2018: Rheumatology
https://www.readbyqxmd.com/read/30014641/-the-study-of-protective-effect-of-paeoniflorin-on-lung-injury-in-mrl-lpr-mice
#14
Chang-Hao Xie, Zhi-Jun Li, Lin-Jie Chen, Ping Zhao, Jia-Jia Zhang, Shan-Wang Bai, Tong Shen, Wen-Xin He, Yuan-Yuan Wang
OBJECTIVE: To investigate the protective effects of paeoniflorin on the lung injury in systemic lupus erythematosus with mouse model. METHODS: Ten wild type mice and 40 MRL/lpr mice were used in this study. MRL/lpr mice were randomly assigned to MRL/lpr group,MRL/lpr + dexamethasone (1.5 mg/kg) group,MRL/lpr + paeoniflorin (20 mg/kg) group,and MRL/lpr + paeoniflorin (40 mg/kg). The levels of malondialdehyde (MDA) , superoxide dismutase (SOD) ,catalase (CAT) ,glutathione peroxidase (GSH-Px) in serum were detected...
May 2018: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/30014357/serum-25-hydroxyvitamin-d3-levels-and-flares-of-systemic-lupus-erythematosus-a-longitudinal-cohort-analysis
#15
Chi Chiu Mok, Eric T Bro, Ling Yin Ho, Ravinder J Singh, Paul J Jannetto
The aim of this study is to evaluate the relationship between baseline serum 25-hydroxyvitamin D3 levels and SLE activity/flares over time. This is a longitudinal study of 276 patients who fulfilled ≥ 4 ACR criteria for SLE and recruited in the year 2011. Serum samples were collected at baseline and assayed for 25-hydroxyvitamin D3 at the end of a mean follow-up of 32.5 months. Participants were stratified into three groups according to baseline 25-hydroxyvitamin D3 levels: group I (< 15 ng/ml, deficiency), group II (15-30 ng/ml, insufficiency), and group III (> 30 ng/ml, adequate)...
July 16, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/30013749/prevalence-of-celiac-disease-serological-markers-in-a-cohort-of-italian-rheumatological-patients
#16
Giacomo Caio, Roberto De Giorgio, Francesco Ursini, Silvia Fanaro, Umberto Volta
Aim: To assess the prevalence of celiac disease (CD) serological markers in a cohort of patients referred to an Italian rheumatological outpatient clinic. Background: Current guidelines do not suggest CD screening in patients with rheumatological diseases and these subjects are not considered to be at high risk for CD. Methods: A total of 230 sera of rheumatological patients referred to the Division of Internal Medicine at the Department of Medical and Surgical Sciences between January 2005 and December 2013 were screened for CD by testing IgA antitransglutaminase (TTG IgA), IgG deamidated gliadin peptides (DGP IgG) and IgA antiendomysium (EMA) antibodies...
2018: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/30013748/prevalence-of-celiac-disease-in-iranian-patients-with-rheumatologic-disorders
#17
Elham Elhami, Zahra Zakeri, Amir Sadeghi, Mohammad Rostami-Nejad, Umberto Volta, Mohammad Reza Zali
Aim: Patients with Systemic Lupus Erythematosus (SLE), Rheumatoid Arthritis (RA), and Fibromyalgia (FM) may have underlying non-diagnosed celiac disease (CD). Background: The aim of this study was to determine the prevalence of CD in patients with these underlying diseases in Iran. Methods: This cross-sectional study was performed among 300 consecutive patients with SLE, RA, and FM (each group 100 patients) since 2015 to 2017. The blood samples were collected and serum IgA anti-tissue trans-glutaminase (Anti-tTG) level was assessed for all patients...
2018: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/30013327/medication-adherence-and-persistence-in-patients-with-autoimmune-rheumatic-diseases-a-narrative-review
#18
REVIEW
Laura-Alexandra Anghel, Andreea Maria Farcaş, Radu Nicolae Oprean
Background: Several drugs are available for the treatment of autoimmune rheumatic diseases; however, their effectiveness may be negatively influenced by inappropriate adherence. Low adherence and persistence rates have a significant impact on patient quality of life and are associated with health-related expenses. Purpose: To provide an up-to-date narrative review on treatment adherence and persistence rates, and discuss the factors that influence them, in patients with autoimmune rheumatic diseases...
2018: Patient Preference and Adherence
https://www.readbyqxmd.com/read/30012398/integrated-therapy-improve-urinary-total-protein-in-patients-with-lupus-nephritis-a-case-report
#19
Pei-Wen Wu, Po-Hsuan Shih, Yen-Ying Kung, Fang-Pey Chen, Ching-Mao Chang
OBJECTIVES: To report on the potential effectiveness of Chinese herbal medicine (CHM) as part of an integrated treatment for lupus nephritis. CLINICAL FEATURES AND OUTCOME: A 55-year-old female with systemic lupus erythematosus had experienced bilateral lower-limbs edema for half a year. Her urinary total protein (M-TP) was 1367.9 mg/24 h. Lupus nephritis (LN) was suspected by the Division of Rheumatology without a renal biopsy. Oral corticosteroid medication did not improve the edema; therefore, the patient requested CHM for integrated therapy, and was subsequently treated for seven months with a modified CHM prescription mainly composed of Zhi-Bo-Di-Huang-Wan, Gui-Shao-Zhi-Mu-Tang, and Zhu-Ling-Tang...
August 2018: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/30009963/vimentin-as-antigenic-target-in-autoimmunity-a-comprehensive-review
#20
REVIEW
Aram Musaelyan, Sergey Lapin, Vladimir Nazarov, Olga Tkachenko, Boris Gilburd, Alexandra Mazing, Lilia Mikhailova, Yehuda Shoenfeld
Vimentin is a protein of intermediate filament family, which is expressed in all mesenchymal cells. Vimentin plays a key role in the physiology of the cell, cellular interactions and the functioning of the immune system. Post-translationally modified and native forms of vimentin are involved in the pathogenesis of inflammation and many autoimmune diseases: rheumatoid arthritis, sarcoidosis, systemic lupus erythematosus, antiphospholipid syndrome, Crohn's disease, ankylosing spondyloarthritis and idiopathic pulmonary fibrosis...
July 12, 2018: Autoimmunity Reviews
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