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Burkholderia cepacia complex

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https://www.readbyqxmd.com/read/27895902/effect-of-%C3%AE-lactamase-inhibitors-on-in-vitro-activity-of-%C3%AE-lactam-antibiotics-against-burkholderia-cepacia-complex-species
#1
Annelien Everaert, Tom Coenye
BACKGROUND: Bacteria belonging to the Burkholderia cepacia complex (Bcc) are an important cause of chronic respiratory tract infections in cystic fibrosis patients. Intrinsic resistance to a wide range of antimicrobial agents, including a variety of β-lactam antibiotics, is frequently observed in Bcc strains. Resistance to β-lactams is most commonly mediated by efflux pumps, alterations in penicillin-binding proteins or the expression of β-lactamases. β-lactamase inhibitors are able to restore the in vitro activity of β-lactam molecules against a variety of Gram-negative species, but the effect of these inhibitors on the activity of β-lactam treatment against Bcc species is still poorly investigated...
2016: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/27889717/clinical-profile-and-antimicrobial-susceptibility-pattern-of-neonatal-sepsis-due-to-burkholderia-capacia-complex
#2
Aparna Chandrasekaran, Nivedhana Subburaju, Muzamil Mustafa, Sulochana Putlibai
We report the clinical profile of 59 neonates who presented to a tertiary care extramural neonatal unit with Burkholderia cepacia complex infection. Among the 3265 admissions over 45 months, incidence of Burkholderia sepsis was 18 per 1000 admissions. Case fatality rate was 17%. Most (95%) isolates were sensitive to cotrimoxazole.
November 5, 2016: Indian Pediatrics
https://www.readbyqxmd.com/read/27886433/the-burkholderia-cenocepacia-peptidoglycan-associated-lipoprotein-is-involved-in-epithelial-cell-attachment-and-elicitation-of-inflammation
#3
Ruth Dennehy, Maria Romano, Alessia Ruggiero, Yasmine F Mohamed, Simon L Dignam, Cristóbal Mujica Troncoso, Máire Callaghan, Miguel A Valvano, Rita Berisio, Siobhán McClean
The Burkholderia cepacia complex (Bcc) is a group of Gram-negative opportunistic pathogens causing infections in people with cystic fibrosis (CF). Bcc is highly antibiotic resistant, making conventional antibiotic treatment problematic. The identification of novel targets for anti-virulence therapies should improve therapeutic options for infected CF patients. We previously identified that the peptidoglycan-associated lipoprotein (Pal) was immunogenic in Bcc infected CF patients; however, its role in Bcc pathogenesis is unknown...
November 7, 2016: Cellular Microbiology
https://www.readbyqxmd.com/read/27879334/intrinsic-resistance-of-burkholderia-cepacia-complex-to-benzalkonium-chloride
#4
Youngbeom Ahn, Jeong Myeong Kim, Ohgew Kweon, Seong-Jae Kim, Richard C Jones, Kellie Woodling, Gonçalo Gamboa da Costa, John J LiPuma, David Hussong, Bernard S Marasa, Carl E Cerniglia
: Pharmaceutical products that are contaminated with Burkholderia cepacia complex (BCC) bacteria may pose serious consequences to vulnerable patients. Benzyldimethylalkylammonium chloride (BZK) cationic surfactants are extensively used in medical applications and have been implicated in the coselection of antimicrobial resistance. The ability of BCC to degrade BZK, tetradecyldimethylbenzylammonium chloride (C14BDMA-Cl), dodecyldimethylbenzylammonium chloride (C12BDMA-Cl), decyldimethylbenzylammonium chloride (C10BDMA-Cl), hexyldimethylbenzylammonium chloride, and benzyltrimethylammonium chloride was determined by incubation in 1/10-diluted tryptic soy broth (TSB) to determine if BCC bacteria have the ability to survive and inactivate these disinfectants...
November 22, 2016: MBio
https://www.readbyqxmd.com/read/27872073/exploring-the-role-of-the-%C3%AE-loop-in-the-evolution-of-ceftazidime-resistance-in-the-pena-%C3%AE-lactamase-from-burkholderia-multivorans-an-important-cystic-fibrosis-pathogen
#5
Krisztina M Papp-Wallace, Scott A Becka, Magdalena A Taracila, Elise T Zeiser, Julian A Gatta, John J LiPuma, Robert A Bonomo
The unwelcome evolution of resistance to the advanced generation cephalosporin antibiotic, ceftazidime is hindering the effective therapy of Burkholderia cepacia complex (Bcc) infections. Regrettably, Bcc are highly resistant to most antibiotics, including polymyxins; ceftazidime and trimethoprim-sulfamethoxazole are the most effective treatment options. Unfortunately, resistance to ceftazidime is increasing and posing a health threat to populations susceptible to Bcc infection. We found that up to 36% of 146 tested Bcc clinical isolates were non-susceptible to ceftazidime...
November 21, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27856590/complete-genome-sequences-for-three-chromosomes-of-the-burkholderia-stabilis-type-strain-atcc-baa-67
#6
Julia V Bugrysheva, Blake Cherney, David Sue, Andrew B Conley, Lori A Rowe, Kristen M Knipe, Michael A Frace, Vladimir N Loparev, Julie R Avila, Kevin Anderson, David R Hodge, Segaran P Pillai, Linda M Weigel
We report here the complete annotated genome sequence of the Burkholderia stabilis type strain ATCC BAA-67. There were three circular chromosomes with a combined size of 8,527,947 bp and G+C composition of 66.4%. These characteristics closely resemble the genomes of other sequenced members of the Burkholderia cepacia complex.
November 17, 2016: Genome Announcements
https://www.readbyqxmd.com/read/27825973/an-efficient-system-for-the-generation-of-marked-genetic-mutants-in-members-of-the-genus-burkholderia
#7
Sravanthi Shastri, Helena L Spiewak, Aderonke Sofoluwe, Vigdis A Eidsvaag, Atif H Asghar, Tyrone Pereira, Edward H Bull, Aaron T Butt, Mark S Thomas
To elucidate the function of a gene in bacteria it is vital that targeted gene inactivation (allelic replacement) can be achieved. Allelic replacement is often carried out by disruption of the gene of interest by insertion of an antibiotic-resistance marker followed by subsequent transfer of the mutant allele to the genome of the host organism in place of the wild-type gene. However, due to their intrinsic resistance to many antibiotics only selected antibiotic-resistance markers can be used in members of the genus Burkholderia, including the Burkholderia cepacia complex (Bcc)...
November 5, 2016: Plasmid
https://www.readbyqxmd.com/read/27804115/eradication-therapy-for-burkholderia-cepacia-complex-in-people-with-cystic-fibrosis
#8
REVIEW
Kate H Regan, Jayesh Bhatt
BACKGROUND: Chronic infection with Burkholderia cepacia complex species remains a significant problem for clinicians treating people with cystic fibrosis. Colonisation with Burkholderia cepacia complex species is linked to a more rapid decline in lung function and increases morbidity and mortality. There remain no objective guidelines for strategies to eradicate Burkholderia cepacia complex in cystic fibrosis lung disease, as these are inherently resistant to the majority of antibiotics and there has been very little research in this area...
November 2, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27789640/draft-genome-sequences-of-burkholderia-contaminans-ffi-28-a-strain-isolated-from-a-contaminated-pharmaceutical-solution
#9
Maria Sol Haim, Marta Mollerach, Gary Van Domselaar, Sergio A Teves, José Degrossi, Silvia T Cardona
Burkholderia contaminans is a species of the Burkholderia cepacia complex, a group of bacteria that can grow in pharmaceutical products and are capable of infecting the immunocompromised and people with cystic fibrosis. Here, we report draft genome sequences for Burkholderia contaminans FFI-28, a strain isolated from a contaminated pharmaceutical solution.
October 27, 2016: Genome Announcements
https://www.readbyqxmd.com/read/27776248/protein-protein-interaction-and-molecular-dynamics-analysis-for-identification-of-novel-inhibitors-in-burkholderia-cepacia-gg4
#10
Money Gupta, Rashi Chauhan, Yamuna Prasad, Gulshan Wadhwa, Chakresh Kumar Jain
The lack of complete treatments and appearance of multiple drug-resistance strains of Burkholderia cepacia complex (Bcc) are causing an increased risk of lung infections in cystic fibrosis patients. Bcc infection is a big risk to human health and demands an urgent need to identify new therapeutics against these bacteria. Network biology has emerged as one of the prospective hope in identifying novel drug targets and hits. We have applied protein-protein interaction methodology to identify new drug-target candidates (orthologs) in Burkhloderia cepacia GG4, which is an important strain for studying the quorum-sensing phenomena...
October 8, 2016: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/27767197/multilocus-sequence-analysis-reveals-high-genetic-diversity-in-clinical-isolates-of-burkholderia-cepacia-complex-from-india
#11
Vikas Gautam, Prashant P Patil, Sunil Kumar, Samriti Midha, Mandeep Kaur, Satinder Kaur, Meenu Singh, Swapna Mali, Jayanthi Shastri, Anita Arora, Pallab Ray, Prabhu B Patil
Burkholderia cepacia complex (Bcc) is a complex group of bacteria causing opportunistic infections in immunocompromised and cystic fibrosis (CF) patients. Herein, we report multilocus sequence typing and analysis of the 57 clinical isolates of Bcc collected over the period of seven years (2005-2012) from several hospitals across India. A total of 21 sequence types (ST) including two STs from cystic fibrosis patient's isolates and twelve novel STs were identified in the population reflecting the extent of genetic diversity...
October 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27731634/screening-complex-biological-samples-with-peptide-microarrays-the-favorable-impact-of-probe-orientation-via-chemoselective-immobilization-strategies-on-clickable-polymeric-coatings
#12
Alessandro Gori, Laura Sola, Paola Gagni, Giulia Bruni, Marta Liprino, Claudio Peri, Giorgio Colombo, Marina Cretich, Marcella Chiari
The generation of robust analytical data using microarray platforms strictly relies on optimal ligand-target interaction at the sensor surface which, in turn, is inherently bound to the correct immobilization scheme of the interrogated bioprobes. In the present work, we performed a rigorous comparative analysis of the impact of peptide ligands immobilization strategy in the screening of Burkholderia cepacia complex (BCC) infections in patients affected by cystic fibrosis (CF). We generated arrays of previously validated Burkholderia-derived peptide probes, that were selectively oriented on polymeric coatings by means of different click-type reactions including thiol-maleimide, copper-catalyzed-azide-alkyne-cycloaddition (CuAAC) and strain-promoted-azide-alkyne-cycloaddition (SPAAC)...
October 12, 2016: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/27696161/impact-of-untreated-urban-waste-on-the-prevalence-and-antibiotic-resistance-profiles-of-human-opportunistic-pathogens-in-agricultural-soils-from-burkina-faso
#13
Benjamin Youenou, Edmond Hien, Amélie Deredjian, Elisabeth Brothier, Sabine Favre-Bonté, Sylvie Nazaret
This study examined the long-term effects of the landfill disposal of untreated urban waste for soil fertilization on the prevalence and antibiotic resistance profiles of various human opportunistic pathogens in soils from Burkina Faso. Samples were collected at three sites in the periphery of Ouagadougou during two campaigns in 2008 and 2011. At each site, amendment led to changes in physico-chemical characteristics as shown by the increase in pH, CEC, total C, total N, and metal contents. Similarly, the numbers of total heterotrophic bacteria were higher in the amended fields than in the control ones...
September 30, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27684048/burkholderia-cenocepacia-k56-2-trimeric-autotransporter-adhesin-bcaa-binds-tnfr1-and-contributes-to-induce-airway-inflammation
#14
Dalila Mil-Homens, Sandra N Pinto, Rute G Matos, Cecília Arraiano, Arsenio M Fialho
Chronic lung disease caused by persistent bacterial infections is a major cause of morbidity and mortality in patients with cystic fibrosis (CF). CF pathogens acquire antibiotic resistance, overcame host defenses and impose uncontrolled inflammation that ultimately may cause permanent damage of lungs' airways. Among the multiple CF-associated pathogens, Burkholderia cenocepacia and other B. cepacia complex (Bcc) bacteria have become prominent contributors of disease progression. Here, we demonstrate that BcaA, a trimeric autotransporter adhesin (TAA) from the epidemic strain B...
September 29, 2016: Cellular Microbiology
https://www.readbyqxmd.com/read/27666507/antimicrobial-susceptibility-of-microorganisms-isolated-from-sputum-culture-of-patients-with-cystic-fibrosis-methicillin-resistant-staphylococcus-aureus-as-a-serious-concern
#15
Narges Mazloomi Nobandegani, Shima Mahmoudi, Babak Pourakbari, Reihaneh Hosseinpour Sadeghi, Mehri Najafi Sani, Fateme Farahmand, Farzaneh Motamed, Raheleh Nabavizadeh Rafsanjani, Setareh Mamishi
INTRODUCTION: Infection is a major cause of morbidity and mortality in patients with cystic fibrosis (CF). Antimicrobial resistance of the bacterial spp. particularly methicillin resistance in Staphylococcus aureus has caused a lot of attention. The aim of this study was to describe the prevalence of S. aureus, Pseudomonas aeruginosa and Burkholderia cepacia-complex as well as their antimicrobial susceptibility patterns in CF patients in an Iranian referral pediatrics Hospital. MATERIAL AND METHODS: From March 2011 until February 2012, 172 samples were collected at the Children Medical Center (CMC), an Iranian referral hospital in Tehran, Iran...
September 22, 2016: Microbial Pathogenesis
https://www.readbyqxmd.com/read/27665523/combination-antimicrobial-susceptibility-testing-of-burkholderia-cepacia-complex-significance-of-species
#16
Felicity K Abbott, Kathleen E N Milne, David A Stead, Ian M Gould
The Burkholderia cepacia complex (Bcc) is notorious for the life-threatening pulmonary infections it causes in patients with cystic fibrosis. The multidrug-resistant nature of Bcc and differing infective Bcc species make the design of appropriate treatment regimens challenging. Previous synergy studies have failed to take account of the species of Bcc isolates. Etest methodology was used to facilitate minimum inhibitory concentration (MIC) and antimicrobial combination testing on 258 isolates of Bcc, identified to species level by matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry (MALDI-TOF/MS)...
September 12, 2016: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/27638346/in-vitro-susceptibility-of-burkholderia-cepacia-complex-isolates-comparison-of-disk-diffusion-etest%C3%A2-agar-dilution-and-broth-microdilution-methods
#17
Lorena Cristina Corrêa Fehlberg, Adriana Gianinni Nicoletti, Ana Carolina Ramos, Fernanda Rodrigues-Costa, Adriana Pereira de Matos, Raquel Girardello, Elizabeth Andrade Marques, Ana Cristina Gales
Broth microdilution, agar dilution, Etest® and disk diffusion techniques were compared to evaluate the susceptibility profile of 82 Bcc clinical isolates against six antimicrobials as recommended by CLSI. Broth microdilution was considered the "gold standard" method. The regression analysis was applied to determine the essential (EA) and categorical (CA) agreement rates. STX (MIC50, 1 mg/L) was the most potent antimicrobial tested against Bcc isolates. The worst in vitro activity was observed for chloramphenicol (MIC50, 16 mg/L) and ticarcillin-clavulanic acid (MIC50, >256 mg/L)...
August 28, 2016: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/27620956/antibiotic-resistance-in-burkholderia-species
#18
Katherine A Rhodes, Herbert P Schweizer
The genus Burkholderia comprises metabolically diverse and adaptable Gram-negative bacteria, which thrive in often adversarial environments. A few members of the genus are prominent opportunistic pathogens. These include Burkholderia mallei and Burkholderia pseudomallei of the B. pseudomallei complex, which cause glanders and melioidosis, respectively. Burkholderia cenocepacia, Burkholderia multivorans, and Burkholderia vietnamiensis belong to the Burkholderia cepacia complex and affect mostly cystic fibrosis patients...
September 2016: Drug Resistance Updates: Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy
https://www.readbyqxmd.com/read/27615705/evolving-serodiagnostics-by-rationally-designed-peptide-arrays-the-burkholderia-paradigm-in-cystic-fibrosis
#19
Claudio Peri, Alessandro Gori, Paola Gagni, Laura Sola, Daniela Girelli, Samantha Sottotetti, Lisa Cariani, Marcella Chiari, Marina Cretich, Giorgio Colombo
Efficient diagnosis of emerging and novel bacterial infections is fundamental to guide decisions on therapeutic treatments. Here, we engineered a novel rational strategy to design peptide microarray platforms, which combines structural and genomic analyses to predict the binding interfaces between diverse protein antigens and antibodies against Burkholderia cepacia complex infections present in the sera of Cystic Fibrosis (CF) patients. The predicted binding interfaces on the antigens are synthesized in the form of isolated peptides and chemically optimized for controlled orientation on the surface...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27515017/the-changing-prevalence-of-pulmonary-infection-in-adults-with-cystic-fibrosis-a-longitudinal-analysis
#20
Kay A Ramsay, Harpreet Sandhu, James B Geake, Emma Ballard, Peter O'Rourke, Claire E Wainwright, David W Reid, Timothy J Kidd, Scott C Bell
BACKGROUND: Increased patient longevity and aggressive antibiotic treatment are thought to impact on the microbial composition of the airways of adults with cystic fibrosis (CF). In this study, we sought to determine if a temporal change in the airway microbiology of adults with CF has occurred over time. METHODS: Longitudinal analysis of sputum microbiology results was undertaken on patients attending a large adult CF centre. Clinical status and health outcomes of transitioning patients were also assessed...
August 8, 2016: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
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