Magali Devriese, François A Lemonnier, Julien Lion, Caroline Sayegh, Emma Fleury, Catherine Shofstall, Lisa Giraldo, Quentin Fiachetti, Cédric Usureau, Hiroko Miyadera, Olivier Toutirais, Nuala Mooney, Dave Lowe, Jean-Luc Taupin
In transplantation, anti-HLA Abs, especially targeting the DQ locus, are well-known to lead to rejection. These Abs identified by Luminex single Ag assays recognize polymorphic amino acids on HLA, named eplets. The HLA Eplet Registry included 83 DQ eplets, mainly deduced from amino acid sequence alignments, among which 66 have not been experimentally verified. Because eplet mismatch load may improve organ allocation and transplant outcomes, it is imperative to confirm the genuine reactivity of eplets to validate this approach...
April 22, 2024: Journal of Immunology