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https://www.readbyqxmd.com/read/29216499/vitamin-d3-decreases-glycolysis-and-invasiveness-and-increases-cellular-stiffness-in-breast-cancer-cells
#1
Julianna Maria Santos, Zeina Shereen Khan, Maliha Tabassum Munir, Kaiser Tarafdar, Shaikh Mizanoor Rahman, Fazle Hussain
Breast cancer is one of the major causes of death in the USA. Cancer cells, including breast, have high glycolysis rates to meet their energy demands for survival and growth. Vitamin D3 (VD3) is important for many important physiological processes such as bone mineralization, but its anticancer role is yet to be proven. We find that VD3 treatment significantly down-regulates glycolytic enzymes and genes and decreases glucose uptake - for both lowly metastatic MCF-7 and highly metastatic MDA-MB-231 (MB231) breast cancer cells...
November 2, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29209277/exenatide-improves-bone-quality-in-a-murine-model-of-genetically-inherited-type-2-diabetes-mellitus
#2
Marie Pereira, Stephanie Gohin, Jean-Paul Roux, Amy Fisher, Mark E Cleasby, Guillaume Mabilleau, Chantal Chenu
Type 2 diabetes mellitus (T2DM) is associated with skeletal complications, including an increased risk of fractures. Reduced blood supply and bone strength may contribute to this skeletal fragility. We hypothesized that long-term administration of Exenatide, a glucagon-like peptide-1 receptor agonist, would improve bone architecture and strength of T2DM mice by increasing blood flow to bone, thereby stimulating bone formation. In this study, we used a model of obesity and severe T2DM, the leptin receptor-deficient db/db mouse to assess alterations in bone quality and hindlimb blood flow and to examine the beneficial effects of 4 weeks administration of Exenatide...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29196931/metabolic-syndrome-and-bone-pharmacologically-induced-diabetes-has-deleterious-effect-on-bone-in-growing-obese-rats
#3
Cedo M Bagi, Kristin Edwards, Edwin Berryman
Metabolic syndrome and osteoporosis share similar risk factors. Also, patients with diabetes have a higher risk of osteoporosis and fracture. Liver manifestations, such as non-alcoholic steatohepatitis (NASH), of metabolic syndrome are further aggravated in diabetics and often lead to liver failure. Our objective was to create a rat model of human metabolic syndrome and determine the long-term impact of early-onset T1D on bone structure and strength in obese growing rats. Male rats were given either standard chow and RO water (Controls) or a high-fat, high-cholesterol diet and sugar water containing 55% fructose and 45% glucose (HFD)...
December 1, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/29196150/sglt2-inhibitors-with-cardiovascular-benefits-transforming-clinical-care-in-type2-diabetes-mellitus
#4
REVIEW
Michael d'Emden, John Amerena, Gary Deed, Carol Pollock, Mark E Cooper
Cardiovascular risk reduction in individuals with Type 2 diabetes mellitus (T2DM) is a key part of clinical management. Sodium-glucose co-transporter (SGLT2) inhibitors improve glycaemic control, reduce body weight and decrease blood pressure. In addition, the SGLT2 inhibitors empagliflozin and canagliflozin reduced the risk of composite cardiovascular events in high-risk individuals with T2DM in the EMPA-REG OUTCOME trial and the CANVAS Program, respectively. Empagliflozin also reduced cardiovascular deaths and improved renal outcomes...
November 28, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29186652/combination-of-obestatin-and-bone-marrow-mesenchymal-stem-cells-prevents-aggravation-of-endocrine-pancreatic-damage-in-type-ii-diabetic-rats
#5
Noha I Hussien, Nesrine Ebrahim, Ola M Mohammed, Dina Sabry
One of the new promising therapies in treatment of diabetes mellitus is mesenchymal stem cells (MSCs) which have an interesting therapeutic potentiality based on their paracrine effect and transdifferentiation potentiality. Also obestatin improves the generation of functional β cells/islet-like cell clusters in vitro, suggesting implications for cell-based replacement therapy in diabetes. So the aim of this study was to evaluate the effect of combination of both MSCs and obestatin on an experimental model of type II diabetes mellitus (T2DM)...
November 30, 2017: International Journal of Stem Cells
https://www.readbyqxmd.com/read/29176994/antiobesity-potential-of-piperonal-promising-modulation-of-body-composition-lipid-profiles-and-obesogenic-marker-expression-in-hfd-induced-obese-rats
#6
Balaji Meriga, Brahmanaidu Parim, Venkata Rao Chunduri, Ramavat Ravindar Naik, Harishankar Nemani, Pothani Suresh, Saravanan Ganapathy, Satthi Babu Vvu
Background: Black pepper or Piper nigrum is a well-known spice, rich in a variety of bioactive compounds, and widely used in many cuisines across the world. In the Indian traditional systems of medicine, it is used to treat gastric and respiratory ailments. The purpose of this investigation is to study the antihyperlipidemic and antiobesity effects of piperonal in high-fat diet (HFD)-induced obese rats. Methods: Piperonal, an active constituent of Piper nigrum seeds, was isolated and confirmed by HPLC, 1H and 13C NMR spectroscopy...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29160901/dietary-advanced-glycation-end-products-have-sex-and-age-dependent-effects-on-vertebral-bone-microstructure-and-mechanical-function-in-mice
#7
Svenja Illien-Jünger, Paolo Palacio-Mancheno, William F Kindschuh, Xue Chen, Grazyna E Sroga, Deepak Vashishth, James C Iatridis
Back pain is a leading cause of global disability that can arise from vertebral fracture and osteoporosis. While poor general health and obesity are among the strongest risk factors for back pain, there is remarkably little known about how diet influences spinal diseases. Advanced glycation endproducts (AGEs) are implicated in increased fracture risk, yet no studies investigated how dietary AGEs affect spinal health. We tested the hypothesis that high dietary AGE ingestion will diminish vertebral structure and function in a sex- and age-dependent manner...
November 21, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29159905/autologous-mesenchymal-stem-cell-and-islet-cotransplantation-safety-and-efficacy
#8
Hongjun Wang, Charlie Strange, Paul J Nietert, Jingjing Wang, Taylor L Turnbull, Colleen Cloud, Stefanie Owczarski, Betsy Shuford, Tara Duke, Gary Gilkeson, Louis Luttrell, Kathie Hermayer, Jyotika Fernandes, David B Adams, Katherine A Morgan
Islet engraftment after transplantation is impaired by high rates of islet/β cell death caused by cellular stressors and poor graft vascularization. We studied whether cotransplantation of ex vivo expanded autologous bone marrow-derived mesenchymal stem cells (MSCs) with islets is safe and beneficial in chronic pancreatitis patients undergoing total pancreatectomy with islet autotransplantation. MSCs were harvested from the bone marrow of three islet autotransplantation patients and expanded at our current Good Manufacturing Practices (cGMP) facility...
November 21, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29150938/regulation-of-calcification-in-human-aortic-smooth-muscle-cells-infected-with-high-glucose-treated-porphyromonas-gingivalis
#9
Te-Chuan Chen, Chien-Tsong Lin, Shao-Ju Chien, Shun-Fu Chang, Cheng-Nan Chen
Porphyromonas (P.) gingivalis infection leading to the periodontitis has been associated with the development of systemic diseases, including cardiovascular diseases and diabetes. However, the effect of a high concentration of glucose (HG) on the invasion efficiency of P. gingivalis and the consequent modulation of pathogenesis in vascular cells, especially in the vascular smooth muscle cells (VSMCs), remains unclear. Hence, the aim of this study was to investigate whether treating P. gingivalis with HG could change its invasion capability and result in VSMC calcification and the underlying mechanism...
November 18, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29149826/novel-functions-of-microrna-17-92-cluster-in-the-endocrine-system
#10
Shan Wan, Xiang Chen, Yuedong He, Xijie Yu
BACKGROUND: MiR-17-92 cluster is coded by MIR17HG in chromosome 13, which is highly conserved in vertebrates. Published literatures have proved that miR-17-92 cluster critically regulates tumorigenesis and metastasis. Recent researches showed that the miR-17-92 cluster also plays novel functions in the endocrine system. OBJECTIVE: To summarize recent findings on the physiological and pathological roles of miR-17-92 cluster in bone, lipid and glucose metabolisms...
November 17, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/29138588/rai1-gene-mutations-mechanisms-of-smith-magenis-syndrome
#11
REVIEW
Mariateresa Falco, Sonia Amabile, Fabio Acquaviva
Smith-Magenis syndrome (SMS; OMIM #182290) is a complex genetic disorder characterized by distinctive physical features, developmental delay, cognitive impairment, and a typical behavioral phenotype. SMS is caused by interstitial 17p11.2 deletions, encompassing multiple genes and including the retinoic acid-induced 1 gene (RAI1), or by mutations in RAI1 itself. About 10% of all the SMS patients, in fact, carry an RAI1 mutation responsible for the phenotype. RAI1 (OMIM *607642) is a dosage-sensitive gene expressed in many tissues and highly conserved among species...
2017: Application of Clinical Genetics
https://www.readbyqxmd.com/read/29137304/monocarboxylate-transporter-1-mct1-a-tool-to-stratify-acute-myeloid-leukemia-aml-patients-and-a-vehicle-to-kill-cancer-cells
#12
Filipa Lopes-Coelho, Carolina Nunes, Sofia Gouveia-Fernandes, Rita Rosas, Fernanda Silva, Paula Gameiro, Tânia Carvalho, Maria Gomes da Silva, José Cabeçadas, Sérgio Dias, Luís G Gonçalves, Jacinta Serpa
Dysregulation of glucose/lactate dynamics plays a role in cancer progression, and MCTs are key elements in metabolic remodeling. VEGF is a relevant growth factor in the maintenance of bone marrow microenvironment and it is also important in hematological diseases. Our aim was to investigate the role of VEGF in the metabolic adaptation of Acute myeloid leukemia (AML) cells by evaluating the metabolic profiles and cell features according to the AML lineage and testing lactate as a metabolic coin. Our in vitro results showed that AML promyelocytic (HL60) and monocytic (THP1) (but not erythroid- HEL) lineages are well adapted to VEGF and lactate rich environment...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29124433/positive-association-between-serum-uric-acid-and-bone-mineral-density-in-chinese-type-2-diabetes-mellitus-stratified-by-gender-and-bmi
#13
Mingxin Xu, Junlei Su, Jie Hao, Ni Zhong, Zhiyin Zhang, Ran Cui, Feng Li, Chunjun Sheng, Ge Zhang, Hui Sheng, Shen Qu
Accumulating evidence has demonstrated that serum uric acid (UA), a natural powerful antioxidant, plays a beneficial role in bone health in the general population. However, few reports are available on the association between serum UA and bone in patients with type 2 diabetes mellitus (T2DM). We therefore investigated whether the benefit of serum UA for bone health was still present in those patients. 626 males and 609 postmenopausal females with T2DM were enrolled in this cross-sectional study. Serum UA concentrations and bone mineral density (BMD) measured at lumbar spine, femoral neck and total hip by dual-energy X-ray absorptiometry were obtained from all subjects...
November 9, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29103907/myeloid-atg16l1-does-not-affect-adipose-tissue-inflammation-or-body-mass-in-mice-fed-high-fat-diet
#14
Evelyn M S Litwinoff, Merav Y Gold, Karan Singh, Jiyuan Hu, Huilin Li, Ken Cadwell, Ann Marie Schmidt
BACKGROUND: An influx of lipid-loaded macrophages characterizes visceral adipose tissue (VAT) inflammation, which is an important factor in the development of insulin resistance (IR) in obesity. Depletion of macrophage lipids accompanies increased whole body insulin sensitivity, but the underlying mechanism is unknown. Deficiency of autophagy protein ATG16L1 is associated with increases in inflammatory diseases and lipid metabolism, but the connection between ATG16L1, IR, and obesity remains elusive...
November 2, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/29099978/glucose-dependent-insulinotropic-polypeptide-gip-inhibits-bone-resorption-independently-of-insulin-and-glycemia
#15
Mikkel B Christensen, Asger Lund, Salvatore Calanna, Niklas R Jørgensen, Jens J Holst, Tina Vilsbøll, Filip K Knop
Context: The gut hormone GIP causes postprandial insulin release and inhibits bone resorption assessed by carboxy-terminal collagen crosslinks (CTX). Objective: To clarify if GIP affects biomarkers involved in bone homeostasis independently of insulin release and glycemic level. Design: Randomized, double-blinded, cross-over study with 5 study days. Patients: Ten lean male C-peptide-negative patients with type 1 diabetes...
November 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29095793/low-dose-sinapic-acid-abates-the-pyroptosis-of-macrophages-via-downregulation-of-lncrna-malat1-in-rats-with-diabetic-atherosclerosis
#16
Yong Han, Hong Qiu, Xing Pei, Yigang Fan, Hongyan Tian, Jie Geng
Pyroptosis is a type of programmed cell death, which has been associated with multiple inflammatory diseases including diabetic atherosclerosis (DA). The study aims to explore the role of sinapic acid (SA) in the pyroptosis of macrophages in diabetic atherosclerosis. Our results from the in vivo experiments showed that low-dose (≤ 50 mg/Kg) chronic SA adiministration suppressed serum endothelin 1 (ET-1) and interleukine-1β (IL-1β) contents, pyroptotic death of bone marrow derived macrophages (BMDMs), and the expression of pyroptotic proteins ASC, NRLP3 and Caspase-1...
October 27, 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29082431/metabolically-healthy-unhealthy-components-may-modify-bone-mineral-density-in-obese-people
#17
Atieh Mirzababaei, Khadijeh Mirzaei, Leila Khorrami-Nezhad, Zhila Maghbooli, Seyed Ali Keshavarz
Link between obesity and bone health is controversial. It seems that maybe the difference in metabolic status leads to this difference. We studied relation between metabolically healthy/unhealthy components with bone mineral density. Results showed metabolically unhealthy obesity (MUHO) phenotypes have better bone status at hip site than metabolically healthy obesity (MHO). Also, component metabolic can effect on BMD in different sites. PURPOSE/INTRODUCTION: This cross-sectional study aimed to compare total BMD and L-L4 BMD in MHO and MUHO base on Karelis criteria...
October 29, 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/29080745/1%C3%AE-25-dihydroxyvitamin-d3-increases-implant-osseointegration-in-diabetic-mice-partly-through-foxo1-inactivation-in-osteoblasts
#18
Yi Xiong, Yixin Zhang, Yanjun Guo, Ying Yuan, Qiang Guo, Ping Gong, Yingying Wu
Oral implant osseointegration is delayed by hyperglycemia-generated oxidative stress (OS). Forkhead transcription factor 1 (FoxO1) is known to be viewed as a sensor to OS since reactive oxide species like H2O2 regulates its activity. We previously demonstrated that 1,25(OH)2D3 favored glucose homeostasis and implant osseointegration in diabetic rats. In this study, we investigated the role of FoxO1OB in the regulation process of 1,25(OH)2D3 on glycometabolism and bone metabolism. We show herein that, with the treatment of 1,25(OH)2D3, mice lacking FoxO1 in osteoblasts (FoxO1OB(-/-)) exhibited decreased serum glucose that was gradually elevated in untreated diabetic mice...
October 26, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29063963/does-oxidative-stress-play-a-role-in-altered-characteristics-of-diabetic-bone-a-systematic-review
#19
REVIEW
Miljana Bacevic, Bozidar Brkovic, Adelin Albert, Eric Rompen, Regis P Radermecker, France Lambert
Diabetes mellitus (DM) has been associated with increased bone fracture rates, impaired bone regeneration, delayed bone healing, and depressed osteogenesis. However, the plausible pathogenic mechanisms remain incompletely understood. The aim of the present systematic review was to investigate whether oxidative stress (OS) plays a role in altered characteristics of diabetic bone under in vivo conditions. An electronic search of the MEDLINE (via PubMed) and Embase databases was performed. In vivo animal studies involving DM and providing information regarding assessment of OS markers combined with analyses of bone histology/histomorphometry parameters were selected...
December 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/29044339/metabolic-acidosis-in-hemodialysis-patients-a-review
#20
Luiza Raksa Rezende, Pablo Brandão de Souza, Giselly Rosa Modesto Pereira, Jocemir Ronaldo Lugon
Metabolic acidosis is highly prevalent in hemodialysis patients. The disorder is associated with increased mortality and its deleterious effects are already present in the predialysis phase of chronic kidney disease. Metabolic acidosis has been linked to progression of chronic kidney disease, changes in protein and glucose metabolism, bone and muscle disorders and cardiovascular disease. At present, the control of metabolic acidosis in hemodialysis is mainly focused on the supply of bicarbonate during dialysis session, but further studies are needed to set the optimum target serum bicarbonate and the best concentration of the bicarbonate dialysate...
July 2017: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
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