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https://www.readbyqxmd.com/read/29652901/early-postnatal-soluble-fgfr3-therapy-prevents-the-atypical-development-of-obesity-in-achondroplasia
#1
Celine Saint-Laurent, Stephanie Garcia, Vincent Sarrazy, Karine Dumas, Florence Authier, Sophie Sore, Albert Tran, Philippe Gual, Isabelle Gennero, Jean-Pierre Salles, Elvire Gouze
BACKGROUND: Achondroplasia is a rare genetic disease is characterized by abnormal bone development and early obesity. While the bone aspect of the disease has been thoroughly studied, early obesity affecting approximately 50% of them during childhood has been somewhat neglected. It nevertheless represents a major health problem in these patients, and is associated to life-threatening complications including increasing risk of cardiovascular pathologies. We have thus decided to study obesity in patients and to use the mouse model to evaluate if soluble FGFR3 therapy, an innovative treatment approach for achondroplasia, could also impact the development of this significant complication...
2018: PloS One
https://www.readbyqxmd.com/read/29649480/high-glucose-downregulates-the-effects-of-autophagy-on-osteoclastogenesis-via-the-ampk-mtor-ulk1-pathway
#2
Zhen-Yu Cai, Bo Yang, Ying-Xu Shi, Wei-Lin Zhang, Fei Liu, Wei Zhao, Mao-Wei Yang
Diabetes is a chronic disease that disrupts the balance between bone formation and bone desorption, which can lead to osteoporosis, increasing the risk of fracture. However, compared with osteoblasts, the biological effects of hyperglycemia on osteoclastogenesis remain to be elucidated. Therefore, we investigated the impact of glucose at different concentrations (5.5, 10.5, 15.5, 20.5, 25.5, and 30.5 mM) on osteoclastogenesis using RAW264.7 cells. Cell proliferation was measured with the cell counting kit-8 assay, and osteoclastogenesis was detected with tartrate-resistant acid phosphatase staining and bone resorption assays, as well as protein cathepsin K expression...
April 9, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29629338/metabolic-symbiosis-and-immunomodulation-how-tumor-cell-derived-lactate-may-disturb-innate-and-adaptive-immune-responses
#3
REVIEW
Alexandre Morrot, Leonardo Marques da Fonseca, Eduardo J Salustiano, Luciana Boffoni Gentile, Luciana Conde, Alessandra Almeida Filardy, Tatiany Nunes Franklim, Kelli Monteiro da Costa, Celio Geraldo Freire-de-Lima, Leonardo Freire-de-Lima
The tumor microenvironment (TME) is composed by cellular and non-cellular components. Examples include the following: (i) bone marrow-derived inflammatory cells, (ii) fibroblasts, (iii) blood vessels, (iv) immune cells, and (v) extracellular matrix components. In most cases, this combination of components may result in an inhospitable environment, in which a significant retrenchment in nutrients and oxygen considerably disturbs cell metabolism. Cancer cells are characterized by an enhanced uptake and utilization of glucose, a phenomenon described by Otto Warburg over 90 years ago...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29621668/exendin-4-relieves-the-inhibitory-effects-of-high-glucose-on-the-proliferation-and-osteoblastic-differentiation-of-periodontal-ligament-stem-cells
#4
Zijun Guo, Rui Chen, Fujun Zhang, Ming Ding, Ping Wang
BACKGROUND: With the impaired regenerative potential in patients with diabetes mellitus (DM), Periodontal ligament stem cells (PDLSCs) are regarded as an attractive source of stem cells for periodontal cytotherapy. Recent studies have shown that Exendin-4 (Ex-4) exerts cell-protective effects and bone remodeling ability on many types of cells. The aim of this study was to investigate whether Ex-4 alleviates the inhibition of high glucose on the proliferation and osteogenic differentiation of PDLSCs...
March 27, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/29609897/increased-prostate-cancer-glucose-metabolism-detected-by-18-f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-in-localised-gleason-8-10-prostate-cancers-identifies-very-high-risk-patients-for-early-recurrence-and-resistance-to-castration
#5
Etienne Lavallée, Michelle Bergeron, François-Alexandre Buteau, Annie-Claude Blouin, Nicolas Duchesnay, Thierry Dujardin, Rabi Tiguert, Louis Lacombe, Vincent Fradet, Molière Makao-Nguile, Yves Fradet, Jean-Mathieu Beauregard, Frédéric Pouliot
BACKGROUND: The accuracy of18 F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) to stage prostate cancer (PCa) is limited. However, Gleason 8-10 PCa and more aggressive metastatic PCa have been shown to exhibit a higher glycolytic activity. OBJECTIVE: To evaluate the potential of intraprostatic FDG uptake to prognose Gleason 8-10 PCa patients prior to prostatectomy, based on tumour intrinsic biology. DESIGN, SETTING, AND PARTICIPANTS: FDG-PET/CT and a bone scan were performed as a staging procedure prior to prostatectomy in 148 consecutive patients diagnosed with PCa with a Gleason sum of ≥8 at biopsy...
March 30, 2018: European Urology Focus
https://www.readbyqxmd.com/read/29608214/heart-rate-and-bone-mineral-density-in-older-women-with-hypertension-results-from-the-korea-national-health-and-nutritional-examination-survey
#6
Mi-Hyang Jung, Ho-Joong Youn, Sang-Hyun Ihm, Hae Ok Jung, Kyung-Soon Hong
OBJECTIVES: To determine whether high heart rate is associated with low bone mineral density (BMD) in older women with hypertension. DESIGN: Retrospective cohort study. SETTING: Population-based study conducted in Korea (Korea National Health and Nutritional Examination Survey 2009-10). PARTICIPANTS: Postmenopausal women aged 60 and older with hypertension (N=981) divided into 2 groups according to resting heart rate, with a cut-off value of 80 bpm, which has been found to be associated with osteoporosis...
April 2, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29606326/dipeptidyl-peptidase-4-inhibitor-vildagliptin-improves-trabecular-bone-mineral-density-and-microstructure-in-obese-insulin-resistant-pre-diabetic-rats
#7
Narattaphol Charoenphandhu, Panan Suntornsaratoon, Piangkwan Sa-Nguanmoo, Pongpan Tanajak, Jarinthorn Teerapornpuntakit, Ratchaneevan Aeimlapa, Nipon Chattipakorn, Siriporn Chattipakorn
OBJECTIVE: Obese insulin resistance and type 2 diabetes mellitus profoundly impair bone mechanical properties and bone quality. However, because several antidiabetes drugs, especially thiazolidinediones, further aggravate bone loss in individuals with diabetes, diabetic osteopathy should not be treated by using simply any glucose-lowering agents. Recently, incretins have been reported to affect osteoblast function positively. The present study aimed to investigate the effects of vildagliptin, an inhibitor of dipeptidyl peptidase-4, on bone of rats with high-fat-diet-induced prediabetes...
February 2, 2018: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/29587220/the-purinergic-p2x7-ion-channel-receptor-a-repair-receptor-in-bone
#8
REVIEW
Niklas Rye Jørgensen
A strong skeleton relies on adaptation to varying physical demands and on maintenance of the bone tissue in order to avoid accumulation of micro-damage. In bone, the purinergic P2X7 ion channel receptor is expressed on both cells of the stromal lineage such as the bone forming osteoblasts and the mechano-sensing osteocytes and on cells belonging to the immune-related monocyte-macrophage lineage, the bone resorbing osteoclasts. Recent studies have demonstrated that the receptor plays important roles in the anabolic responses to mechanical loading on bone and, together with the pannexin1 hemi-channel, in the process of initiating bone remodeling in response to micro-damage...
March 24, 2018: Current Opinion in Immunology
https://www.readbyqxmd.com/read/29587203/inhibitor-of-bruton-s-tyrosine-kinases-pci-32765-decreases-pro-inflammatory-mediators-production-in-high-glucose-induced-macrophages
#9
Zhe Fan, Yan Wang, Xingxin Xu, Yonggui Wu
Accumulating evidence has shown that macrophages play a vital role in development and pathogenesis of diabetic nephropathy (DN) by secreting inflammatory cytokines. Although Bruton's tyrosine kinases (Btk) is a biologically important molecule implicated in immune regulation, the role of Btk in high glucose (HG)-stimulated inflammatory response in macrophages and the mechanism involved need further investigation. In our study, we used bone marrow-derived macrophages (BMMs) to investigate the involvement of Btk on HG-induced inflammatory cytokines expression and to explore the underlying mechanisms...
March 24, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29582132/association-of-plasma-irisin-with-bone-mineral-density-in-a-large-chinese-population-using-an-extreme-sampling-design
#10
Long-Fei Wu, Dong-Cheng Zhu, Chang-Hua Tang, Bing Ge, Ju Shi, Bing-Hua Wang, Yi-Hua Lu, Pei He, Wen-Yu Wang, Si-Qi Lu, Jiao Zhong, Xu Zhou, Kan Zhu, Wen Ji, Hong-Qin Gao, Hong-Bo Gu, Xing-Bo Mo, Xin Lu, Lei Zhang, Yong-Hong Zhang, Fei-Yan Deng, Shu-Feng Lei
Irisin, a myokine produced by skeletal muscle in response to physical exercise, promotes trans-differentiation of white adipose tissue into brown adipose tissue. Recent evidences suggested that irisin also plays an important role in the control of bone metabolism. This study aimed to ascertain the relationship between plasma irisin and bone mineral density (BMD) in Chinese population by adoption of an extreme sampling method. Based on a large and screened Chinese elderly population (N = 6308), two subgroups with extremely high and low hip BMD were selected for discovery (N = 80, high vs...
March 26, 2018: Calcified Tissue International
https://www.readbyqxmd.com/read/29565507/analysis-of-the-correlation-between-non-alcoholic-fatty-liver-disease-and-bone-metabolism-indicators-in-healthy-middle-aged-men
#11
H Deng, Y Dai, H Lu, S-S Li, L Gao, D-L Zhu
OBJECTIVE: To investigate the relationship between bone metabolic indicators and non-alcoholic fatty liver disease (NAFLD) in healthy middle-aged men. PATIENTS AND METHODS: The bone metabolic indicators of 232 healthy middle-age men with NAFLD (NAFLD group) and 308 healthy controls without fatty liver (Control group) were measured, including non-collagenous osteocalcin, the procollagen type 1 N-terminal propeptide (P1NP), beta-C-terminal telopeptide of type I collagen (β-CTX)...
March 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29527173/obesity-metabolic-syndrome-and-musculoskeletal-disease-common-inflammatory-pathways-suggest-a-central-role-for-loss-of-muscle-integrity
#12
REVIEW
Kelsey H Collins, Walter Herzog, Graham Z MacDonald, Raylene A Reimer, Jaqueline L Rios, Ian C Smith, Ronald F Zernicke, David A Hart
Inflammation can arise in response to a variety of stimuli, including infectious agents, tissue injury, autoimmune diseases, and obesity. Some of these responses are acute and resolve, while others become chronic and exert a sustained impact on the host, systemically, or locally. Obesity is now recognized as a chronic low-grade, systemic inflammatory state that predisposes to other chronic conditions including metabolic syndrome (MetS). Although obesity has received considerable attention regarding its pathophysiological link to chronic cardiovascular conditions and type 2 diabetes, the musculoskeletal (MSK) complications (i...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29522773/effects-of-ovariectomy-and-exercise-training-intensity-on-energy-substrate-and-hepatic-lipid-metabolism-and-spontaneous-physical-activity-in-mice
#13
Marc A Tuazon, Sara C Campbell, Dylan J Klein, Sue A Shapses, Keith R Anacker, Tracy G Anthony, Mehmet Uzumcu, Gregory C Henderson
BACKGROUND: Menopause is associated with fatty liver, glucose dysregulation, increased body fat, and impaired bone quality. Previously, it was demonstrated that single sessions of high-intensity interval exercise (HIIE) are more effective than distance- and duration-matched continuous exercise (CE) on altering hepatic triglyceride (TG) metabolism and very-low density lipoprotein-TG (VLDL-TG) secretion. METHODS: Six weeks training using these modalities was examined for effects on hepatic TG metabolism/secretion, glucose tolerance, body composition, and bone mineral density (BMD) in ovariectomized (OVX) and sham-operated (SHAM) mice...
March 6, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29521037/human-physiological-and-metabolic-responses-to-an-attempted-winter-crossing-of-antarctica-the-effects-of-prolonged-hypobaric-hypoxia
#14
Katie A O'Brien, Ross D Pollock, Mike Stroud, Rob J Lambert, Alex Kumar, Robert A Atkinson, David A Green, Ana Anton-Solanas, Lindsay M Edwards, Steve D R Harridge
An insufficient supply of oxygen to the tissues (hypoxia), as is experienced upon high-altitude exposure, elicits physiological acclimatization mechanisms alongside metabolic remodeling. Details of the integrative adaptive processes in response to chronic hypobaric hypoxic exposure remain to be sufficiently investigated. In this small applied field study, subjects (n = 5, male, age 28-54 years) undertook a 40 week Antarctica expedition in the winter months, which included 24 weeks residing above 2500 m...
March 2018: Physiological Reports
https://www.readbyqxmd.com/read/29518749/sglt2-inhibition-reduces-atherosclerosis-by-enhancing-lipoprotein-clearance-in-ldlr-type-1-diabetic-mice
#15
Annas Al-Sharea, Andrew J Murphy, L A Huggins, Y Hu, Ira J Goldberg, Prabhakara R Nagareddy
BACKGROUND AND AIMS: Leukocytosis, particularly monocytosis, has been shown to promote atherosclerosis in both diabetic and non-diabetic mouse models. We previously showed that hyperglycemia independently promotes monocytosis and impairs the resolution of atherosclerosis. Since patients with chronic diabetes often develop dyslipidemia and also have increased risk for atherosclerosis, we sought to examine how controlling blood glucose affects atherosclerosis development in the presence of severe hyperlipidemia...
March 2, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29516387/the-evolving-role-of-fdg-pet-ct-in-the-diagnosis-staging-and-treatment-of-breast-cancer
#16
Koosha Paydary, Siavash Mehdizadeh Seraj, Mahdi Zirakchian Zadeh, Sahra Emamzadehfard, Sara Pourhassan Shamchi, Saeid Gholami, Thomas J Werner, Abass Alavi
The applications of 2-deoxy-2-[18 F]fluoro-D-glucose positron emission tomography/X-ray computed tomography (PET/CT) in the management of patients with breast cancer have been extensively studied. According to these studies, PET/CT is not routinely performed for the diagnosis of primary breast cancer, although PET/CT in specific subtypes of breast cancer correlates with histopathologic features of the primary tumor. PET/CT can detect metastases to mediastinal, axial, and internal mammary nodes, but it cannot replace the sentinel node biopsy...
March 7, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29507854/primary-intramedullary-malignant-lymphoma-in-the-cervical-cord-with-a-presyrinx-state
#17
Kohei Chida, Atsushi Sugawara, Takahiro Koji, Takaaki Beppu, Yoshiharu Mue, Tamotsu Sugai, Knuaki Ogasawara
A 79-year-old man presented with primary intramedullary malignant lymphoma with a presyrinx state in the cervical cord manifesting as left hemiparesis and hemidysesthesia. The magnetic resonance imaging (MRI) scan showed an intramedullary mass in the cervical spinal cord at the level of C1 and T2-weighted image prolongation from the medulla to the level of C5. According to the progression of hemiparesis, he underwent an emergency removal of the tumor under general anesthesia. The tumor was totally removed, and the peritumoral signal abnormality was not present in the postoperative MRI...
December 30, 2017: Curēus
https://www.readbyqxmd.com/read/29506157/bone-turnover-markers-in-patients-with-non-alcoholic-fatty-liver-disease-and-or-type-2-diabetes-during-oral-glucose-and-isoglycemic-iv-glucose
#18
Henrik Maagensen, Anders E Junker, Niklas R Jørgensen, Lise L Gluud, Filip K Knop, Tina Vilsbøll
Context: Non-alcoholic fatty liver disease (NAFLD) is associated with type 2 diabetes (T2D) and vice versa, and both conditions are associated with an increased risk of fractures and altered bone turnover. While NAFLD patients typically suffer from decreased bone mineral density (BMD), T2D is associated with normal to high BMD. The pathophysiology is uncertain, but may involve the gut-bone axis. Objective: We investigated the influence of the gut on glucose-induced changes in plasma bone turnover markers in healthy controls and patients with T2D and/or biopsy-verified NAFLD...
March 1, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29501744/lncrna-pdia3p-interacts-with-c-myc-to-regulate-cell-proliferation-via-induction-of-pentose-phosphate-pathway-in-multiple-myeloma
#19
Xiangchou Yang, Haihao Ye, Muqing He, Xiaohai Zhou, Ni Sun, Wenjian Guo, Xiaoji Lin, He Huang, Ying Lin, Rongxin Yao, Hong Wang
Multiple myeloma (MM), the second most common hematologic malignancy, is an incurable disease characterized by the accumulation of malignant plasma cells within the bone marrow. Though great progresses have been made in understanding the mechanisms of MM, metabolic plasticity and drug resistance remain largely unknown. In this study, we found lncRNA Protein disulfide isomerase family A member 3 pseudogene 1 (PDIA3P) is highly expressed in MM and is associated with the survival rate of MM patients. PDIA3P regulates MM growth and drug resistance through Glucose 6-phosphate dehydrogenase (G6PD) and the pentose phosphate pathway (PPP)...
March 25, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29499687/prevalence-of-excessive-body-fat-among-adolescents-of-a-south-brazilian-metropolitan-region-and-state-capital-associated-risk-factors-and-consequences
#20
Leandra Ulbricht, Mariane Ferreira de Campos, Eduardo Esmanhoto, Wagner Luis Ripka
BACKGROUND: The prevalence of overweight/obesity has become a major concern for public health in developing countries. Risk factors need to be well documented so that these countries develop public policies to fight the problem. Thus, the objective of this study is to determine the prevalence of excess fat among adolescents of a South Brazilian State Capital associated with risk factors and their consequences. METHODS: This study was conducted between 2014 and 2016 with adolescents aged 11-18 years...
March 2, 2018: BMC Public Health
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