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https://www.readbyqxmd.com/read/28527105/association-between-lumbar-bone-mineral-density-and-serum-uric-acid-in-postmenopausal-women-a-cross-sectional-study-of-healthy-chinese-population
#1
Wen Han, Xiaojuan Bai, Nan Wang, Lulu Han, Xuefeng Sun, Xiangmei Chen
Partial correlation and regression analyses were used in this study. We showed that there is a linear relationship between bone mineral density and serum uric acid within the normal physiologic range, and higher serum uric acid levels had a protective effect on bone loss in postmenopausal osteoporosis. PURPOSE: The significance of the relationship between lumbar bone mineral density (()BMD) and serum uric acid (SUA) levels is unclear. The aims of this study were to investigate on a population-level the association between lumbar BMD and SUA within the normal physiologic range and to determine whether SUA plays a protective role in bone loss in healthy postmenopausal Chinese women...
December 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/28523955/collaborative-cross-mouse-population-for-studying-the-alveolar-bone-changes-and-impaired-glucose-tolerance-comorbidity-after-high-fat-diet-consumption
#2
Aysar Nashef, Hanifa J Abu-Toamih Atamni, Yuval Buchnik, Hatice Hasturk, Alpdogan Kantarci, Danielle Stephens, Ervin I Wiess, Yael Houri-Haddad, Fuad A Iraqi
BACKGROUND: High-fat diet (HFD), body weight (BW) gain and impaired glucose tolerance development were associated with alveolar bone loss in susceptible individuals. This report explores the Collaborative Cross (CC) mouse population for studying the impact of genetic background on the comorbidity of alveolar bone change and glucose tolerance following HFD consumption. METHODS: 78 mice from 19 different CC lines were maintained on rodents chow diet (CH) for 8 weeks, and subsequently, transferred to HFD (42% Fat) for an additional 12 weeks...
May 19, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28521869/high-fgf21-levels-are-associated-with-altered-bone-homeostasis-in-hiv-1-infected-patients
#3
José M Gallego-Escuredo, Maria Karuna Lamarca, Joan Villarroya, Joan C Domingo, Ma Gracia Mateo, Ma Del Mar Gutierrez, Francesc Vidal, Francesc Villarroya, Pere Domingo, Marta Giralt
BACKGROUND: Fibroblast growth factor-21 (FGF21) has emerged as an important regulator of glucose, lipid, and body weight homeostasis. However, recent experimental studies have reported that increased FGF21 levels may lead to bone loss. OBJECTIVE: To assess the relationship of serum FGF21 levels and altered bone homeostasis in HIV-1-infected patients. DESIGN: Cross-sectional study of 137 HIV-1-infected patients and 35 healthy controls conducted at the Hospital de la Santa Creu i Sant Pau, Barcelona...
June 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28513571/fat-sugar-and-bone-health-a-complex-relationship
#4
REVIEW
Li Tian, Xijie Yu
With people aging, osteoporosis is expected to increase notably. Nutritional status is a relatively easily-modified risk factor, associated with many chronic diseases, and is involved in obesity, diabetes, and coronary heart disease (CHD), along with osteoporosis. Nutrients, such as fats, sugars, and proteins, play a primary function in bone metabolism and maintaining bone health. In Western nations, diets are generally high in saturated fats, however, currently, the nutritional patterns dominating in China continue to be high in carbohydrates from starch, cereals, and sugars...
May 17, 2017: Nutrients
https://www.readbyqxmd.com/read/28494015/long-non-coding-rna-lethe-regulates-hyperglycemia-induced-reactive-oxygen-species-production-in-macrophages
#5
Carlos Zgheib, Maggie M Hodges, Junyi Hu, Kenneth W Liechty, Junwang Xu
Type 2 diabetes mellitus is a complex, systemic metabolic disease characterized by insulin resistance and resulting hyperglycemia, which is associated with impaired wound healing. The clinical complications associated with hyperglycemia are attributed, in part, to the increased production of reactive oxygen species (ROS). Recent studies revealed that long non-coding RNAs (lncRNAs) play important regulatory roles in many biological processes. Specifically, lncRNA Lethe has been described as exhibiting an anti-inflammatory effect by binding to the p65 subunit of NFκB and blocking its binding to DNA and the subsequent activation of downstream genes...
2017: PloS One
https://www.readbyqxmd.com/read/28470822/pericyte-derived-bone-morphogenetic-protein-4-underlies-white-matter-damage-after-chronic-hypoperfusion
#6
Maiko T Uemura, Masafumi Ihara, Takakuni Maki, Takayuki Nakagomi, Seiji Kaji, Kengo Uemura, Tomohiro Matsuyama, Raj N Kalaria, Ayae Kinoshita, Ryosuke Takahashi
Subcortical small vessel disease (SVD) is characterized by white matter damage resulting from arteriolosclerosis and chronic hypoperfusion. Transforming growth factor beta 1 (TGFB1) is dysregulated in the hereditary SVD, CARASIL (cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy). However, very little is known about the role of the largest group in the TGFB superfamily - the bone morphogenetic proteins (BMPs) - in SVD pathogenesis. The aim of this study was to characterize signaling abnormalities of BMPs in sporadic SVD...
May 4, 2017: Brain Pathology
https://www.readbyqxmd.com/read/28467440/serum-biomarkers-in-patients-with-ossification-of-the-posterior-longitudinal-ligament-opll-inflammation-in-opll
#7
Yoshiharu Kawaguchi, Masato Nakano, Taketoshi Yasuda, Shoji Seki, Kayo Suzuki, Yasuhito Yahara, Hiroto Makino, Isao Kitajima, Tomoatsu Kimura
BACKGROUD: Ossification of the posterior longitudinal ligament (OPLL) is characterized by replacement of ligamentous tissue by ectopic new bone formation. OPLL causes narrowing of the spinal canal, resulting in neurological impairment. However, the pathogenesis of OPLL has not been fully elucidated. We investigated whether inflammation occurs in OPLL or not using high-sensitivity CRP (hs-CRP) in a case-control study. METHODS AND FINDINGS: This study included 103 patients with OPLL in the patient group and 95 age- and sex-matched volunteers with degenerative spinal disease in the control group...
2017: PloS One
https://www.readbyqxmd.com/read/28462510/runx2-alleviates-high-glucose-suppressed-osteogenic-differentiation-via-pi3k-akt-gsk3%C3%AE-%C3%AE-catenin-pathway
#8
Yang Chen, Yun Hu, Lan Yang, Jie Zhou, Yuying Tang, Leilei Zheng, Pu Qin
Hyperglycemia is one of the most important pathogenesis of diabetic osteopathy. Several lines of studies indicate Runx2 plays a critical role in the process of osteogenic differentiation. However, little studies have analysed the effect of Runx2 on osteoblast differentiation of rat bone mesenchymal stem cells (rBMSCs) in high glucose condition. In this study, the effect of Runx2 on osteoblast differentiation in high glucose condition was evaluated by the expression of osteogenesis-related maker including Runx2, ALP, OC and OPN, as well as ALP staining, ALP activity and Alizarin red S staining...
April 29, 2017: Cell Biology International
https://www.readbyqxmd.com/read/28460884/enhanced-therapeutic-benefit-of-quercetin-loaded-phytosome-nanoparticles-in-ovariectomized-rats
#9
Abeer I Abd El-Fattah, Mohamed M Fathy, Zeinab Y Ali, Abd El-Rahman A El-Garawany, Ehsan K Mohamed
Quercetin, a dietary flavonol phytoestrogen, has many health benefits but it is poorly absorbed when administered orally. To improve its bioavailability, we prepared quercetin-loaded phytosome nanoparticles (QP) using the thin film hydration method. The prepared nano-formulations were characterized using different techniques. Transmission electron microscopy revealed the homogeneously spherical, well and uniformly dispersed, nano-sized nature of QP. Dynamic light scattering measurements of QP (70 ± 7.44 nm) also confirmed this...
April 29, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28447734/high-glucose-promotes-the-osteogenic-differentiation-capability-of-human-periodontal-ligament-fibroblasts
#10
Sujiwan Seubbuk, Hathaitip Sritanaudomchai, Julalux Kasetsuwan, Rudee Surarit
Periodontal ligament fibroblasts (PDLFs) are important cells, which are involved in maintaining tooth integrity. Diabetes has been found to be associated with periodontal disease in a bidirectional manner. The aim of the present study was to investigate the stemness properties of human PDLFs (HPDLFs) in high glucose conditions. HPDLFs were analyzed for their osteogenic differentiation capacity by inducing the cells with osteogenic medium in various glucose concentrations. The gene expression was then examined using reverse transcription‑quantitative polymerase chain reaction analysis, and examinations of alkaline phosphatase activity and nodule formation were performed...
May 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28445487/bmt-decreases-hfd-induced-weight-gain-associated-with-decreased-preadipocyte-number-and-insulin-secretion
#11
Saeed Katiraei, Lisa R Hoving, Lianne van Beek, Sharida Mohamedhoesein, Françoise Carlotti, Janna A van Diepen, Patrick C N Rensen, Mihai G Netea, Ko Willems van Dijk, Jimmy F P Berbée, Vanessa van Harmelen
Experimental bone marrow transplantation (BMT) in mice is commonly used to assess the role of immune cell-specific genes in various pathophysiological settings. The application of BMT in obesity research is hampered by the significant reduction in high-fat diet (HFD)-induced obesity. We set out to characterize metabolic tissues that may be affected by the BMT procedure and impair the HFD-induced response. Male C57BL/6 mice underwent syngeneic BMT using lethal irradiation. After a recovery period of 8 weeks they were fed a low-fat diet (LFD) or HFD for 16 weeks...
2017: PloS One
https://www.readbyqxmd.com/read/28424263/the-kielin-chordin-like-protein-kcp-attenuates-high-fat-diet-induced-obesity-and-metabolic-syndrome-in-mice
#12
Abdul Soofi, Katherine I Wolf, Margo P Emont, Nathan Qi, Gabriel Martinez-Santibanez, Edward Grimley, Wesam Ostwani, Gregory R Dressler
Obesity and its associated complications, such as insulin resistance and non-alcoholic fatty liver disease, are reaching epidemic proportions. In mice, the TGF-beta superfamily is implicated in the regulation of white and brown adipose tissue differentiation. The Kielin/chordin-like Protein (KCP) is a secreted regulator of the TGF-beta superfamily pathways that can inhibit both TGF-beta and activin signals while enhancing bone morphogenetic protein (BMP) signaling. However, KCP's effects on metabolism and obesity have not been studied in animal models...
April 19, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28419209/estrogen-deficiency-exacerbates-type-1-diabetes-induced-bone-tnf%C3%AE-expression-and-osteoporosis-in-female-mice
#13
Sandi Raehtz, Hayley Bierhalter, Daniel Schoenherr, Narayanan Parameswaran, Laura R McCabe
Estrogen deficiency following menopause is associated with rapid bone loss, osteoporosis and increased fracture risk. Type 1 Diabetes (T1D), characterized by hypoinsulinemia and hyperglycemia, is also associated with bone loss and increased fracture risk. With better treatment options, T1D patients are living longer and therefore the number of patients having both T1D and estrogen deficiency is increasing. Little is known about the mechanistic impact of T1D in conjunction with estrogen deficiency on bone physiology and density...
April 14, 2017: Endocrinology
https://www.readbyqxmd.com/read/28408068/quercus-infectoria-inhibits-set7-nf-%C3%AE%C2%BAb-inflammatory-pathway-in-macrophages-exposed-to-a-diabetic-environment
#14
Julalak Chokpaisarn, Norifumi Urao, Supayang P Voravuthikunchai, Timothy J Koh
Chronic inflammation plays a key role in the pathogenesis of myriad complications associated with diabetes and thus anti-inflammatory therapies may ameliorate these complications. Quercus infectoria (Qi) extract has been shown to downregulate inflammatory processes; however, the molecular mechanisms of this anti-inflammatory activity remain unclear. The hypothesis of our study was that Qi extract exerts its anti-inflammatory effect by downregulating the Set7/NF-κB pathway. Bone marrow-derived macrophages (BMM) were treated with high glucose plus palmitate medium (HG/Pa) to simulate the diabetic environment...
April 10, 2017: Cytokine
https://www.readbyqxmd.com/read/28396584/a-high-glucose-diet-affects-achilles-tendon-healing-in-rats
#15
Stefanie Korntner, Nadja Kunkel, Christine Lehner, Renate Gehwolf, Andrea Wagner, Peter Augat, Daniel Stephan, Verena Heu, Hans-Christian Bauer, Andreas Traweger, Herbert Tempfer
Chronic and acute tendinopathies are difficult to treat and tendon healing is generally a very slow and incomplete process and our general understanding of tendon biology and regeneration lags behind that of muscle or bone. Although still largely unexplored, several studies suggest a positive effect of nutritional interventions on tendon health and repair. With this study, we aim to reveal effects of a high-glucose diet on tendon neoformation in a non-diabetic rat model of Achilles tenotomy. After surgery animals received either a high-glucose diet or a control diet for 2 and 4 weeks, respectively...
April 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28396116/beta-2-adrenergic-receptor-agonists-are-novel-regulators-of-macrophage-activation-in-diabetic-renal-and-cardiovascular-complications
#16
Hyunjin Noh, Mi Ra Yu, Hyun Joo Kim, Ji Hye Lee, Byoung-Won Park, I-Hsien Wu, Motonobu Matsumoto, George L King
Macrophage activation is increased in diabetes and correlated with the onset and progression of vascular complications. To identify drugs that could inhibit macrophage activation, we developed a cell-based assay and screened a 1,040 compound library for anti-inflammatory effects. Beta2-adrenergic receptor (β2AR) agonists were identified as the most potent inhibitors of phorbol myristate acetate-induced tumor necrosis factor-α production in rat bone marrow macrophages. In peripheral blood mononuclear cells isolated from streptozotocin-induced diabetic rats, β2AR agonists inhibited diabetes-induced tumor necrosis factor-α production, which was prevented by co-treatment with a selective β2AR blocker...
April 7, 2017: Kidney International
https://www.readbyqxmd.com/read/28394345/cripto-and-its-signaling-partner-grp78-drive-the-metastatic-phenotype-in-human-osteotropic-prostate-cancer
#17
E Zoni, L Chen, S Karkampouna, Z Granchi, E I Verhoef, F La Manna, J Kelber, R C M Pelger, M D Henry, E Snaar-Jagalska, G J L H van Leenders, L Beimers, P Kloen, P C Gray, G van der Pluijm, M Kruithof-de Julio
CRIPTO (CR-1, TDGF1) is a cell surface/secreted oncoprotein actively involved in development and cancer. Here, we report that high expression of CRIPTO correlates with poor survival in stratified risk groups of prostate cancer (PCa) patients. CRIPTO and its signaling partner glucose-regulated protein 78 (GRP78) are highly expressed in PCa metastases and display higher levels in the metastatic ALDH(high) sub-population of PC-3M-Pro4Luc2 PCa cells compared with non-metastatic ALDH(low). Coculture of the osteotropic PC-3M-Pro4Luc2 PCa cells with differentiated primary human osteoblasts induced CRIPTO and GRP78 expression in cancer cells and increases the size of the ALDH(high) sub-population...
April 10, 2017: Oncogene
https://www.readbyqxmd.com/read/28388723/high-sclerostin-and-dickkopf-1-dkk-1-serum-levels-in-children-and-adolescents-with-type-1-diabetes-mellitus
#18
Maria Felicia Faienza, Annamaria Ventura, Maurizio Delvecchio, Anna Fusillo, Laura Piacente, Gabriella Aceto, Graziana Colaianni, Silvia Colucci, Luciano Cavallo, Maria Grano, Giacomina Brunetti
Context: Childhood type 1 diabetes mellitus (T1DM) is associated with decreased bone mass. Sclerostin and dickkopf-1 (DKK-1) are Wnt inhibitors that regulate bone formation. Objective: To evaluate sclerostin and DKK-1 levels in T1DM children and to analyze the influence of glycemic control on bone health. Design and setting: Cross-sectional study conducted at a clinical research center. Participants: One hundred and six T1DM subjects (12...
April 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28365712/determinants-of-advanced-bone-age-in-childhood-obesity%C3%A2
#19
Cornelis J de Groot, Adriaan van den Berg, Bart E P B Ballieux, Herman M Kroon, Edmond H H M Rings, Jan M Wit, Erica L T van den Akker
BACKGROUND: Childhood obesity is associated with advanced bone age (BA). Previous studies suggest that androgens, oestrogens, sex hormone-binding globulin, and insulin are responsible for this phenomenon, but results are contradictory and might be biased by confounders. We aim to elucidate this matter by applying a multivariate approach. METHOD: We performed a correlation analysis of BA standard deviation score (SDS) with age- and sex-specific SDS for androgens, oestrogens, and with indicators of insulin secretion derived from oral glucose tolerance testing, in a group of obese children...
March 31, 2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/28362046/co-microencapsulation-of-bmscs-and-mouse-pancreatic-%C3%AE-cells-for-improving-the-efficacy-of-type-i-diabetes-therapy
#20
Ruimin Long, Yuangang Liu, Shibin Wang, Li Ye, Peng He
INTRODUCTION: To overcome the shortcomings of pancreas transplantation and insulin injection treatment for type I diabetes, biocompatible materials were used to prepare alginate-chitosan-alginate microcapsules that co-encapsulated bone marrow mesenchymal stem cells and mouse pancreatic β cells to treat diabetic mice. METHODS: Blank alginate-chitosan-alginate (ACA) microcapsules and co-microencapsulated cells were prepared using a high-voltage electrostatic method and then characterized using an inverted microscope...
May 9, 2017: International Journal of Artificial Organs
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