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quality of life in systemic lupus erythematosus

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https://www.readbyqxmd.com/read/29659589/correlation-between-physical-markers-and-psychiatric-health-in-a-portuguese-systemic-lupus-erythematosus-cohort-the-role-of-suffering-in-chronic-autoimmune-disease
#1
Margarida Figueiredo-Braga, Caleb Cornaby, Miguel Bernardes, Marta Figueiredo, Cristina Dos Santos Mesquita, Lúcia Costa, Brian D Poole
BACKGROUND: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that affects a large number of people throughout the world. Anxiety, depression and fatigue are common symptoms of SLE that substantially contribute to decreased quality of life. This study investigates the interplay between physical and psychiatric manifestations of lupus. To this end, an SLE patient cohort was examined for correlations between clinical presentation, laboratory tests, and psychological indicators...
2018: PloS One
https://www.readbyqxmd.com/read/29611343/work-disability-in-argentinian-patients-with-systemic-lupus-erythematosus-is-prevalent-and-it-is-due-to-ethnic-socioeconomic-and-disease-related-factors
#2
Cecilia N Pisoni, Sebastián A Muñoz, María N Tamborenea, Mercedes García, Ana Curti, Ana Cappuccio, Oscar Rillo, Patricia M Imamura, Emilce Schneeberger, Marcela Ballent, Mario L Cousseau, Jorge Velasco Zamora, Verónica Saurit, Sergio Toloza, María C Danielsen, Verónica I Bellomio, Cesar Graf, Sergio Paira, Javier Cavallasca, Bernardo Pons Estel, José L C Moreno, Mónica Díaz, Paula Alba, Marcela Verando, Guillermo Tate, Eduardo Mysler, Judith Sarano, Emma E Civit, Fabián Risueño, Pablo Álvarez Sepúlveda, María S Larroude, Marcos F Méndez, Andrea Conforti, Débora Sohn
OBJECTIVE: To study the prevalence and the associated factors of work disability (WD) in systemic lupus erythematosus (SLE) patients. METHODS: A sample of 419 SLE patients from an observational cross-sectional multicenter study was included. Sociodemographic features, disease characteristics, comorbidities, quality of life, unhealthy behaviors, and work-related factors were measured in a standardized interview. Work disability was defined by patient self-report of not being able to work because of SLE...
April 2, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29600935/rheumatoid-arthritis-patients-achieved-better-quality-of-life-than-systemic-lupus-erythematosus-patients-at-sustained-remission
#3
Virginia Pascual-Ramos, Irazú Contreras-Yáñez, Katya R Valencia-Quiñones, Juanita Romero-Díaz
OBJECTIVES: In 2004 and 1999, respectively, recent-onset rheumatoid arthritis (RA) and systemic lupus erythematous (SLE) cohorts were initiated; the 36 item Medical Outcome Study Short-Form survey (SF-36) was applied beginning from enrolment. The objectives were to compare the SF-36v2 scores between patients from both cohorts who achieved sustained remission and to define the role of disease diagnosis as associated to SF-36v2 normative data in remission patients. METHODS: Sustained remission was considered when RA and SLE patients achieved at least 12 months of continuous follow-up with either SLE disease activity index 2000 update =0 or Disease Activity Score (28 joints) ≤2...
March 21, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29594125/attribution-of-neuropsychiatric-manifestations-to-systemic-lupus-erythematosus
#4
REVIEW
Alessandra Bortoluzzi, Carlo Alberto Scirè, Marcello Govoni
Neuropsychiatric (NP) involvement in systemic lupus erythematosus (SLE) is one of the most severe manifestations of the disease that has a heavy impact on patient's functioning, quality of life, and disease outcome. The prevalence is highly variable and the clinical phenotypes vary from common syndromes to rare NP entities. Its occurrence may be the result of a primary manifestation of SLE, secondary to other conditions (such as infections or metabolic disturbances) or the effect of concomitant comorbidities that often complicate the disease course...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29589214/association-of-tumor-necrosis-factor-alpha-induced-protein-3-interacting-protein-1-tnip1-gene-polymorphism-rs7708392-with-lupus-nephritis-in-egyptian-patients
#5
Mohamed Moustafa Rizk, Eman Tayae Elsayed, Ahmed Fathi ElKeraie, Ireny Ramzy
Lupus nephritis (LN) is a major cause of morbidity and mortality in systemic lupus erythematosus (SLE). Previous studies suggest that mutant A20 binding inhibitor of NF-κB 1 (ABIN1) protein encoded by tumor necrosis factor alpha-induced protein 3 interacting protein 1 (TNIP1) gene is associated with LN via NF-κB dysregulation. The aim of the current study was to evaluate the association of TNIP1 gene SNP rs7708392 with SLE and LN in Egyptian patients. 5' nuclease Allelic discrimination was used to evaluate the frequency of TNIP1 SNP rs7708392 in 53 patients with LN, 57 SLE patients without nephritis and 85 healthy controls...
March 27, 2018: Biochemical Genetics
https://www.readbyqxmd.com/read/29582096/living-with-systemic-lupus-erythematosus-in-the-developing-world
#6
REVIEW
A Phuti, M Schneider, M Tikly, B Hodkinson
Most of our understanding of SLE and its negative impact originates from developed countries. This review aims to collate existing literature on Health-Related Quality of Life (HRQoL) in SLE patients living in developing countries to identify the gaps for the focus of future research. A narrative literature review was compiled using selected MeSH terms to search EBSCOHOST for articles published between January 1975 and February 2018 pertaining to HRQoL in SLE patients in developing countries. 31 studies from 11 countries were included for analysis...
March 26, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29554346/women-with-systemic-lupus-erythematosus-get-pregnant-more-easily-than-women-with-rheumatoid-arthritis
#7
Carina Götestam Skorpen, Stian Lydersen, Inge-Margrethe Gilboe, Johan Fredrik Skomsvoll, Kjell Å Salvesen, Øyvind Palm, Hege Suorza Svean Koksvik, Bente Jakobsen, Marianne Wallenius
Objectives: To examine possible differences in the ability to get pregnant and time to pregnancy (TTP) in women with SLE and RA, and to study possible influencing factors. Methods: Data from RevNatus, a Norwegian nationwide prospective observational register including women with inflammatory rheumatic diseases when planning pregnancy or after conception, was used. We compared rate of achieved pregnancy, the pregnancy outcomes live birth or pregnancy loss, and TTP between women with SLE (n = 53) and women with RA (n = 180)...
March 14, 2018: Rheumatology
https://www.readbyqxmd.com/read/29548997/fty720-attenuates-behavioral-deficits-in-a-murine-model-of-systemic-lupus-erythematosus
#8
Dongyan Shi, Tongguan Tian, Shu Yao, Kelei Cao, Xingxing Zhu, Mingshun Zhang, Shuang Wen, Longjun Li, Meiqing Shi, Hong Zhou
Neuropsychiatric (NP) involvement in systemic lupus erythematosus (SLE) severely impacts patients' quality of life and leads to a poor prognosis. The current therapeutic protocol, corticosteroid administration, can also induce neuropsychiatric disorders. FTY720 is an immunomodulator that selectively confines lymphocytes in lymph nodes and reduces autoreactive T cell recruitment to the central nervous system (CNS). This study aimed to identify a novel therapeutic strategy for NPSLE. B6.MRL-lpr mice were treated with oral administration of FTY720 (2 mg/kg) three times per week for 12 weeks, to evaluate its efficacy in a model of NPSLE...
March 13, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29540088/retraction-notice
#9
(no author information available yet)
At the request of the Journal's Editor, the Publisher and the authors, the following article has been retracted. Li J, Jones JT, Donnelly C, Cunningham N, Kashikar-Zuck S and Brunner HI. Pain predicts poorer health-related quality of life in childhood-onset systemic lupus erythematosus: a cohort study. Journal of International Medical Research. Epub ahead of print 6 December 2017. DOI: 10.1177/0300060517732486 . http://journals.sagepub.com/doi/full/10.1177/0300060517732486 The article has been retracted from Journal of International Medical Research because the co-authors of the paper had not consented to the paper's submission for publication, and because the paper does not present the complete findings of the authors' research...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29505598/physical-activity-and-sedentary-behavior-in-patients-with-systemic-lupus-erythematosus
#10
Domenico Paolo Emanuele Margiotta, Fabio Basta, Giulio Dolcini, Veronica Batani, Marina Lo Vullo, Alessia Vernuccio, Luca Navarini, Antonella Afeltra
INTRODUCTION: The aim of this study was to evaluate the proportion of patients with Systemic Lupus Erythematosus (SLE) who did not met the WHO recommendations for physical activity and to evaluate the amount of time spent in sedentary behavior. METHODS: SLE patients were consecutively enrolled in a cross sectional study. The type and the time spent in physical activity and sedentary behavior were evaluated using the IPAQ short form questionnaire. The adequate physical activity was defined according to the 2010 WHO recommendations for health and the sedentary behavior according to the 2017 SBRN consensus...
2018: PloS One
https://www.readbyqxmd.com/read/29481735/lgals9-deficiency-attenuates-nephritis-and-arthritis-in-pristane-induced-lupus-model-of-balb-c-mice
#11
Sonia Zeggar, Katsue S Watanabe, Sanae Teshigawara, Sumie Hiramatsu, Takayuki Katsuyama, Eri Katsuyama, Haruki Watanabe, Yoshinori Matsumoto, Tomoko Kawabata, Ken-Ei Sada, Toshiro Niki, Mitsuomi Hirashima, Jun Wada
OBJECTIVE: In systemic lupus erythematosus (SLE), an autoimmune disease associated with multiple organ involvements, lupus nephritis determines prognosis and arthritis impairs quality of life of patients. Galectin-9 (Gal-9, Lgals9) is a β-galactoside binding lectin and the attempts for its clinical application have been made in autoimmune diseases, since recombinant Gal-9 as a ligand for Tim-3 induces apoptosis in activated CD4+ Tim-3+ Th1 cell. We investigated wethere the deficiency of Lgals9 is beneficial or deleterious in lupus mice models...
February 26, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29461425/antibodies-and-the-brain-antiribosomal-p-protein-antibody-and-the-clinical-effects-in-patients-with-systemic-lupus-erythematosus
#12
Alfonso González, Loreto Massardo
PURPOSE OF REVIEW: Analysis of antiribosomal P protein autoantibodies (anti-P) pathogenicity in diffuse brain manifestations of neuropsychiatric lupus, emphasizing cognitive dysfunction and the recently emerged role of cross-reacting neuronal surface P antigen (NSPA) in α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and N-Methyl-D-Aspartate receptor glutamatergic transmission. RECENT FINDINGS: Circulating anti-P antibodies associate with executive planning dysfunction and attention impairments in lupus patients and perturb glutamatergic transmission through NSPA in mice hippocampus, translating into impaired synaptic plasticity and spatial memory...
February 15, 2018: Current Opinion in Neurology
https://www.readbyqxmd.com/read/29451066/psychometric-properties-of-mdhaq-rapid3-in-patients-with-systemic-lupus-erythematosus
#13
N Annapureddy, D Giangreco, H Devilliers, J A Block, M Jolly
Background The Multidimensional Health Assessment Questionnaire (MDHAQ) is a patient-reported outcome (PRO) tool that includes the Routine Assessment of Patient Index Data 3 (RAPID3), an index that can be calculated at the point of care. The objective of this study was to perform psychometric analyses of MDHAQ/RAPID3 to study its measurement properties in systemic lupus erythematosus (SLE). Methods The MDHAQ was completed by 161 SLE patients in routine care, along with LupusPRO (a disease-specific PRO). The SLE disease-specific activity index (SELENA-SLEDAI) and damage (SDI) were assessed...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29396833/belimumab-a-review-in-systemic-lupus-erythematosus
#14
Hannah A Blair, Sean T Duggan
Belimumab (Benlysta® ) is a human immunoglobulin G1λ monoclonal antibody that inhibits the binding of soluble B lymphocyte stimulator to B cells. It is the only biological agent currently approved for the treatment of non-renal systemic lupus erythematosus (SLE). Belimumab is approved in the EU, the USA and other countries as add-on therapy in adult patients with active, autoantibody-positive SLE despite standard therapy. In phase III trials, treatment with IV or SC belimumab plus standard therapy was effective in terms of reducing overall disease activity and reducing the incidence and severity of flares, without worsening of patients' overall condition or the development of significant disease activity in new organ systems...
March 2018: Drugs
https://www.readbyqxmd.com/read/29384702/the-correlations-of-psychological-status-quality-of-life-self-esteem-social-support-and-body-image-disturbance-in-chinese-patients-with-systemic-lupus-erythematosus
#15
Qian Zhao, Haoyang Chen, Hongyan Yan, Yan He, Li Zhu, WenTing Fu, Biyu Shen
This study aimed (i) to complement existing research by focusing on body image disturbance issues in Chinese Systemic Lupus Erythematosus (SLE) patients; (ii) to investigate how Chinese patients make sense of disease diagnosis and perceived cultural influences within the context of their SLE. A total of 118 SLE patients underwent standardized laboratory examinations and completed several questionnaires. Independent sample t-test, Mann-Whitney U-test, Chi-square test, and multivariate analysis using backward stepwise logistic regression model were used to analyze these data...
January 31, 2018: Psychology, Health & Medicine
https://www.readbyqxmd.com/read/29316357/cerebrovascular-events-in-systemic-lupus-erythematosus
#16
John G Hanly, Qiuju Li, Li Su, Murray B Urowitz, Caroline Gordon, Sang-Cheol Bae, Juanita Romero-Diaz, Jorge Sanchez-Guerrero, Sasha Bernatsky, Ann E Clarke, Daniel J Wallace, David A Isenberg, Anisur Rahman, Joan T Merrill, Paul Fortin, Dafna D Gladman, Ian N Bruce, Michelle Petri, Ellen M Ginzler, M A Dooley, Kristjan Steinsson, Rosalind Ramsey-Goldman, Asad A Zoma, Susan Manzi, Ola Nived, Andreas Jonsen, Munther A Khamashta, Graciela S Alarcón, Winn Chatham, Ronald F van Vollenhoven, Cynthia Aranow, Meggan Mackay, Guillermo Ruiz-Irastorza, Manuel Ramos-Casals, S Sam Lim, Murat Inanc, Kenneth C Kalunian, Soren Jacobsen, Christine A Peschken, Diane L Kamen, Anca Askanase, Chris Theriault, Vernon Farewell
OBJECTIVE: To determine the frequency, associations and outcomes of cerebrovascular events (CerVEs) in a multi-ethnic/racial, prospective, SLE disease inception cohort. METHODS: Patients were assessed annually for 19 neuropsychiatric (NP) events including 5 types of CerVEs: (i) Stroke; (ii) Transient ischemia; (iii) Chronic multifocal ischemia; (iv) Subarachnoid/intracranial hemorrhage; (v) Sinus thrombosis. Global disease activity (SLEDAI-2K), SLICC/ACR damage index (SDI) and SF-36 scores were collected...
January 5, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29310537/individuals-living-with-lupus-findings-from-the-lupus-uk-members-survey-2014
#17
C Morgan, A R Bland, C Maker, J Dunnage, I N Bruce
Systemic lupus erythematosus (SLE) is a complex and unpredictable disease which varies greatly among patients and has a significant impact on an individual's daily living and quality of life. A better understanding of the patients' experiences with the disease is vital to the effective management of the disease. LUPUS UK, a national UK-registered charity supporting people with systemic and discoid lupus, conducted a UK-wide survey of individuals living with lupus in order to provide foundation information to support and identify gaps needing further research...
April 2018: Lupus
https://www.readbyqxmd.com/read/29301472/factors-associated-with-health-related-quality-of-life-in-peruvian-patients-with-systemic-lupus-erythematosus
#18
Claudia Elera-Fitzcarrald, Magaly Alva, Rocío Gamboa-Cardenas, Claudia S Mora-Trujillo, Francisco Zevallos, Augusto García-Poma, Mariela Medina, Zoila Rodriguez-Bellido, Risto A Perich-Campos, César A Pastor-Asurza, María I Segami, Manuel F Ugarte-Gil
Objective In this paper, we aim to define factors associated with health-related quality of life (HRQoL) in Mestizo patients with systemic lupus erythematosus (SLE). Methods We evaluated patients with SLE from Peru's two largest hospitals between October 2012 and July 2015 to ascertain HRQoL. Using a standard protocol, we incorporated demographic characteristics, clinical manifestations and treatment in our analysis. HRQoL was measured with the LupusQoL, disease activity was ascertained with the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI), and damage was appraised with the Systemic Lupus International Collaborating Clinics (SLICC)/American College of Rheumatology (ACR) damage index (SDI)...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29261752/a-comparison-of-health-related-quality-of-life-hrqol-across-four-systemic-autoimmune-rheumatic-diseases-sards
#19
Julia Greenfield, Marie Hudson, Evelyne Vinet, Paul R Fortin, Vivian Bykerk, Christian A Pineau, Mianbo Wang, Sasha Bernatsky, Murray Baron
OBJECTIVES: To compare physical and mental health-related quality of life (HRQoL) across four systemic autoimmune rheumatic diseases (SARD). METHODS: Incident subjects enrolled in four SARD cohorts, namely systemic lupus erythematosus (SLE), systemic sclerosis (SSc), rheumatoid arthritis (RA) and idiopathic inflammatory myopathies (IIM) were studied. The outcomes of interest were baseline Short Form Health Survey physical (PCS) and mental (MCS) component summary scores...
2017: PloS One
https://www.readbyqxmd.com/read/29241417/neuropsychiatric-manifestations-are-not-uncommon-in-indian-lupus-patients-and-negatively-affect-quality-of-life
#20
H Muhammed, M Goyal, V Lal, S Singh, V Dhir
Objectives The objectives of this paper are to look at the prevalence of neuropsychiatric manifestations and assess their impact on quality of life in North Indian lupus patients. Methods The study included consecutive patients with systemic lupus erythematosus (SLE) who were older than 18 years and met the SLICC 2012 criteria. A diagnosis of a neuropsychiatric syndrome was made as per ACR 1999 definitions. Manifestations occurring at any point in time after the diagnosis of SLE were considered if a reliable history and medical records were available...
April 2018: Lupus
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