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Kamonpun Ussavarungsi, Ryan M Kern, Anja C Roden, Jay H Ryu, Eric S Edell
BACKGROUND: Diagnostic evaluation of patients with diffuse parenchymal lung disease (DPLD) is best achieved by a multidisciplinary team correlating clinical, radiologic, and pathologic features. Surgical lung biopsies remain the gold standard for histopathologic diagnosis of idiopathic interstitial pneumonias. Emerging data suggest an increasing role for transbronchial cryobiopsy (TBC) in DPLD evaluation. We describe our experience with TBC in patients with DPLD. METHODS: We retrospectively reviewed medical records of patients with radiographic features of DPLD who underwent TBC at Mayo Clinic, Rochester, Minnesota in June 2013-September 2015...
September 19, 2016: Chest
Thomas V Colby, Sara Tomassetti, Alberto Cavazza, Alessandra Dubini, Venerino Poletti
Context .- Transbronchial cryobiopsy has recently been proposed as an alternative to surgical biopsy in the diagnosis of diffuse lung disease. Objective .- To familiarize pathologists with transbronchial cryobiopsy, including what it is, how it is performed, how it compares to other techniques of lung biopsy in diffuse lung disease, what are the technical issues relating to it, what the complications are, how cryobiopsies should be interpreted, and the clinical usefulness of cryobiopsy. Data Sources .- All the available literature on cryobiopsy in diffuse lung disease through May 2016, primarily in the last 5 years, was reviewed, and some unpublished data known to the authors were included...
September 2, 2016: Archives of Pathology & Laboratory Medicine
Hiang-Ping Chan, Mei-Fong Liew, Ju-Ee Seet, Pyng Lee
No abstract text is available yet for this article.
August 31, 2016: Thorax
L Richeldi
The recent approval of two safe and effective treatments for patients with idiopathic pulmonary fibrosis (IPF) had as a direct consequence the absolute need for an accurate and early diagnosis. The standard approach to IPF diagnosis has proven to be effective and emphasized the importance of clinical and laboratory evaluations to exclude known causes of pulmonary fibrosis. At the same time, chest high-resolution computed tomography (HRCT) has proven to be the crucial initial diagnostic test, by identifying those patients who should undergo surgical lung biopsy to secure a confident diagnosis and an adequate treatment...
September 2016: QJM: Monthly Journal of the Association of Physicians
C Sharp, M McCabe, H Adamali, A R Medford
BACKGROUND: Histological diagnosis by surgical lung biopsy for interstitial lung disease (ILD) is currently limited. Transbronchial cryobiopsy via flexible bronchoscope may this for more patients. The relative costs, diagnostic yields and safety of this approach and more traditional approaches have not been determined. OBJECTIVES: To perform a systematic review and meta-analysis of transbronchial cryobiopsy, forceps transbronchial biopsy and video assisted (VATS) surgical lung biopsy assessing their relative diagnostic yields and safety...
August 13, 2016: QJM: Monthly Journal of the Association of Physicians
Kerri A Johannson, Veronica S Marcoux, Paul E Ronksley, Christopher J Ryerson
RATIONALE: The diagnostic usefulness and safety of transbronchial lung cryobiopsy for the evaluation of interstitial lung disease remain unclear. OBJECTIVES: This systematic review and metaanalysis aims to establish the diagnostic accuracy and yield of transbronchial cryobiopsy for interstitial lung diseases. METHODS: We searched MedLine, EMBASE, Cochrane Central Register of Controlled Trials, and conference proceedings to identify studies assessing the diagnostic accuracy (compared with surgical biopsy) or yield of transbronchial lung cryobiopsy for interstitial lung disease (from database inception to January 2016)...
October 2016: Annals of the American Thoracic Society
Kirtee Raparia, Dara L Aisner, Timothy Craig Allen, Mary Beth Beasley, Alain Borczuk, Philip T Cagle, Vera Capelozzi, Sanja Dacic, Lida P Hariri, Keith M Kerr, Sylvie Lantuejoul, Mari Mino-Kenudson, Natasha Rekhtman, Anja C Roden, Sinchita Roy-Chowdhuri, Lynette Sholl, Maxwell L Smith, Eric Thunnissen, Ming Sound Tsao, Yasushi Yatabe
Transbronchial lung cryobiopsy involves using a cryoprobe rather than forceps to obtain a bronchoscopic biopsy. Recent studies have shown that transbronchial cryobiopsy provides a larger specimen than conventional transbronchial forceps biopsy, and that the interobserver agreement in the interpretation of cryobiopsy specimens is comparable to that of a surgical lung biopsy. This is encouraging, and transbronchial lung cryobiopsy clearly has a role in the workup and diagnosis of interstitial lung diseases. However, very few patients who have been studied underwent both transbronchial lung cryobiopsy and surgical lung biopsy, and the available data suggest that the diagnostic accuracy of cryobiopsy may not be similar to that of surgical lung biopsy...
July 21, 2016: Archives of Pathology & Laboratory Medicine
Sergej Griff, Wim Ammenwerth, Nicolas Schönfeld, Torsten T Bauer, Thomas Mairinger, Torsten-Gerriet Blum, Jens Kollmeier, Wolfram Grüning
No abstract text is available yet for this article.
2016: Diagnostic Pathology
Fatih Segmen, Zafer Aktaş, Ayperi Öztürk, Derya Kızılgöz, Aydın Yılmaz, Ibrahim Onur Alıcı, Funda Demirağ, Polat Pehlivanoğlu
BACKGROUND: Cryobiopsy, which provides larger specimens without crush artifact, is a good option for the diagnosis of visible endobronchial tumors. While there are several papers on diagnostic performance, application protocols vary between centers. In this study, we aimed to find the optimal number of cryobiopsies in endobronchial tumors. METHODS: We prospectively involved cases with a visible endobronchial tumor in which conventional diagnostic measures failed and/or a therapeutic interventional bronchoscopy was planned...
July 13, 2016: Surgical Endoscopy
H Wurps, N Schönfeld, T T Bauer, M Bock, C Duve, R Sauer, T Mairinger, S Griff
BACKGROUND: There is only few data available on the use of cryotechnique during medical thoracoscopy. METHODS: Medical thoracoscopy was performed in consecutive patients with pleural effusion. Prospectively, biopsies were taken by rigid forceps, flexible forceps and cryoprobe. Specimen size, depth and diagnostic yield were compared. RESULTS: 80 Patients were included. 408 biopsies were taken (205 rigid biopsies, 104 flexible biopsies, 99 cryobiopsies)...
2016: BMC Pulmonary Medicine
Matthew Ing, Rema A Oliver, Brian G G Oliver, William R Walsh, Jonathan P Williamson
BACKGROUND: Transbronchial lung biopsy using a cryoprobe is a novel way of sampling lung parenchyma. Correlation of freezing time with biopsy size and complications has not been evaluated in vivo. OBJECTIVES: The primary aim of the study is to evaluate the correlation between transbronchial cryobiopsy freezing time and size. The secondary aims are to evaluate histological quality of the biopsy and evaluate procedure-associated complications. METHODS: Transbronchial lung cryobiopsies were obtained from two anaesthetised sheep using a 1...
2016: Respiration; International Review of Thoracic Diseases
Burcu Cirit Koçer, Yurdanur Erdoğan, Berna Akıncı Özyürek, Sertaç Büyükyaylacı Özden, Funda Demirağ
Paraneoplastic secretion of beta human chorionic gonadotropin (β-HCG) in non-small cell lung cancer (NSCLC) has been rarely reported. A 43-year old male patient was admitted with dyspnea and chest pain. Thorax computed tomography (CT) revealed bilateral multiple masses and pleural effusion at right hemithorax. Positron emission tomography (PET)-CT showed pathologic 18 FDG uptake at mass lesions and mediastinal lymph nodes. The serum β-HCG level was elevated. A bronchoscopy was performed and endobronchial lesion was observed...
March 2016: Tüberküloz Ve Toraks
José A Cascante, Pilar Cebollero, Sonia Herrero, Adriana Yagüe, Ana Echegoyen, Jesús Elizalde, Javier Hueto
BACKGROUND: A definitive and specific diagnosis of interstitial lung disease (ILD) often requires a histologic analysis of the lung parenchyma. A transbronchial biopsy with forceps has a limited diagnostic yield for idiopathic interstitial pneumonias. The incorporation of a transbronchial lung cryobiopsy for diagnosing ILD appears to be very promising, although there are only a few published studies in this regard. Our paper shows the results of using this technique in our center. METHODS: This was a prospective study including 55 patients with ILD diagnosed from January 2012 to January 2015...
July 2016: Journal of Bronchology & Interventional Pulmonology
José Javier Echevarria-Uraga, Julio Pérez-Izquierdo, Nerea García-Garai, Estíbaliz Gómez-Jiménez, Amaia Aramburu-Ojembarrena, Luis Tena-Tudanca, José L Miguélez-Vidales, Alberto Capelastegui-Saiz
BACKGROUND AND OBJECTIVE: Transbronchial cryobiopsy (TBCB) is a technique in which frozen samples of lung are obtained using a probe inserted through a bronchoscope. We performed a retrospective study to assess the performance of the TBCB procedure complemented by segmental bronchial blockade using an angioplasty balloon, in terms of diagnostic yield and safety in diffuse parenchymal lung disease (DPLD). METHODS: Data from 100 patients with suspected DPLD (clinical and radiological findings), who underwent TBCB in our institution to establish a definitive diagnosis, were reviewed...
August 2016: Respirology: Official Journal of the Asian Pacific Society of Respirology
Ferran Morell, Ana Villar, Iñigo Ojanguren, Xavier Muñoz, María-Jesús Cruz
This review presents an update of the currently available information related to hypersensitivity pneumonitis, with a particular focus on the contribution of several techniques in the diagnosis of this condition. The methods discussed include proper elaboration of a complete medical history, targeted auscultation, detection of specific immunoglobulin G antibodies against the most common antigens causing this disease, skin tests, antigen-specific lymphocyte activation assays, bronchoalveolar lavage, and cryobiopsy...
June 2016: Seminars in Respiratory and Critical Care Medicine
Lars Hagmeyer, Dirk Theegarten, Marcel Treml, Christina Priegnitz, Winfried Randerath
BACKGROUND: Transbronchial Cryobiopsy (Cryo-TBB) represents a new approach for sampling lung tissue in interstitial lung disease (ILD). OBJECTIVES: Comparing the reliability of Cryo-TBB results and the procedure's complication rates with the procedure of surgical lung biopsy (SLB). METHODS: ILD subjects with the need of lung tissue sampling are analyzed in this prospective trial. To determine the relevance of procedure-related complications the pooled data from the ongoing and previous Cryo-TBB studies were compared with pooled data from previous SLB studies in an interim analysis...
March 29, 2016: Sarcoidosis, Vasculitis, and Diffuse Lung Diseases: Official Journal of WASOG
Robert J Lentz, Joshua P Fessel, Joyce E Johnson, Fabien Maldonado, Robert F Miller, Otis B Rickman
No abstract text is available yet for this article.
April 1, 2016: American Journal of Respiratory and Critical Care Medicine
Nina M Patel, Alain C Borczuk, David J Lederer
No abstract text is available yet for this article.
April 1, 2016: American Journal of Respiratory and Critical Care Medicine
Oormila Ganganah, Shu Liang Guo, Manu Chiniah, Yi Shi Li
Forceps biopsy (FB) is the most commonly used diagnostic tool for lung pathologies. FB is associated with a high diagnostic failure rate. Cryobiopsy (CB) is a novel technique providing a larger specimen size, few artefacts, more alveolar parts and superior diagnostic yield. CB, however, has drawbacks such as higher bleeding and pneumothorax rate. We conducted a meta-analysis to investigate the specimen area, diagnostic rate and bleeding severity in CB versus FB in interstitial lung diseases (ILDs) and lung tumours...
July 2016: Respirology: Official Journal of the Asian Pacific Society of Respirology
Venerino Poletti, Claudia Ravaglia, Sara Tomassetti
PURPOSE OF REVIEW: The diagnostic yield of conventional transbronchial lung biopsy varies among various parenchymal lung diseases: in pulmonary sarcoidosis and lymphangitis carcinomatosa, a diagnosis can be obtained in up to 80% of patients; this method is considered inadequate, however, in identifying more complex histological patterns such as usual interstitial pneumonitis or nonspecific interstitial pneumonitis, mainly because the specimens are tiny and the interpretation is confounded by crush artifacts...
May 2016: Current Opinion in Pulmonary Medicine
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