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https://www.readbyqxmd.com/read/28742013/first-canadian-experience-with-donation-after-cardiac-death-simultaneous-pancreas-and-kidney-transplants
#1
Patrick T Anderson, Shahid Aquil, Kelly McLean, Vivian C McAlister, Alp Sener, Patrick P Luke
BACKGROUND: Compared with neurologic determination of death (NDD) donor organs, donation after cardiac death (DCD) donor organs have traditionally been considered of inferior quality owing to warm ischemia experienced during procurement. We present, to our knowledge, the first analysis of simultaneous pancreas and kidney (SPK) transplants using DCD donor organs in Canada. METHODS: We carried out a retrospective cohort study of SPK transplants from 13 DCD and 68 NDD donors performed between October 2008 and July 2016...
August 1, 2017: Canadian Journal of Surgery. Journal Canadien de Chirurgie
https://www.readbyqxmd.com/read/28741700/financial-aspects-of-organ-procurement-from-deceased-donors-in-the-usa-relevance-to-xenotransplantation
#2
REVIEW
Ryan J Saari, David K C Cooper
When clinical xenotransplantation is introduced, the costs associated with acquisition of a genetically engineered pig organ are as yet unknown. How will these costs compare with those currently associated with the acquisition of deceased human organs? An understanding of the financial aspects of deceased organ and tissue procurement in the USA is therefore worthwhile. We have therefore attempted to review certain economic aspects of non-profit and for-profit organizations that provide cadaveric organs and/or tissues for purposes of transplantation into patients with end-stage organ failure, cellular deficiencies, or in need of reconstructive procedures...
July 25, 2017: Xenotransplantation
https://www.readbyqxmd.com/read/28739153/active-donor-management-during-the-hospital-phase-of-care-is-associated-with-more-organs-transplanted-per-donor
#3
Madhukar S Patel, Salvador De La Cruz, Mitchell B Sally, Tahnee Groat, Darren J Malinoski
BACKGROUND: Meeting donor management goals (DMGs) while caring for potential organ donors has been associated with more organs transplanted per donor (OTPD). Concern persists, however, as to whether this reflects that younger/healthier donors are more likely to meet DMGs or whether active management affects outcomes. STUDY DESIGN: A prospective observational study of all standard criteria donors (SCDs) was conducted by 10 organ procurement organizations across UNOS Regions 4, 5, and 6...
July 21, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28736022/use-of-nanoice-for-procurement-achieves-better-cooling-of-liver-grafts
#4
J D Reyes, F G Jalikis, L C Olson, M Yeh, M I Montenovo
BACKGROUND: Rapid cooling at procurement after cross-clamping has been the cornerstone of organ preservation. NanoICE is a new form of ice that has emerged in the food industry and is providing more efficient cooling and preservation than regular ice. We hypothesize that the use of NanoICE will accelerate the cooling process of the allograft and will be able to maintain a steady low temperature without causing any significant histologic damage. METHODS: In this randomized pilot study, 14 pigs were used to study the liver core/surface cooling in a non-survival organ procurement operation...
July 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28736012/sent-liver-grafts-do-not-have-a-detrimental-impact-on-post-transplant-outcome
#5
D Dondossola, M Cavenago, B Antonelli, P Reggiani, U Maggi, G Rossi, L Caccamo
INTRODUCTION: "Sent livers" (SL) (interregional allocated organs) are considered extended donor criteria grafts. These grafts influence post-transplant outcome. In our donor allocation program, the number of allocated SLs is increasing. The aim of our study is to provide data supporting the possibility to enlarge the use of SLs through adequate donor-to-recipient matching. METHODS: A retrospective analysis was carried out from our prospective-collected database during 2014...
July 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28730184/associations-between-deceased-donor-urine-mcp-1-and-kidney-transplant-outcomes
#6
S G Mansour, J Puthumana, P P Reese, I E Hall, M D Doshi, F L Weng, B Schröppel, H Thiessen-Philbrook, M Bimali, C R Parikh
INTRODUCTION: Existing methods to predict recipient allograft function during deceased-donor kidney procurement are imprecise. Understanding the potential renal reparative role for monocyte chemoattractant protein-1 (MCP-1), a cytokine involved in macrophage recruitment after injury, might help predict allograft outcomes. METHODS: We conducted a sub-study of the multicenter prospective Deceased Donor Study cohort, which evaluated deceased kidney donors from five organ procurement organizations from May 2010 to December 2013...
July 2017: KI Reports
https://www.readbyqxmd.com/read/28730094/organ-transplantation-scandal-influencing-corneal-donation-rate
#7
Tobias Röck, Matthias Bramkamp, Karl Ulrich Bartz-Schmidt, Daniel Röck
In the majority of countries, there is a shortage of donor corneas for corneal transplantations. This study investigated the impact of organ transplantation scandals on corneal donation rate at the University Hospital Tübingen. Each deceased patient was considered as a potential corneal donor. An ophthalmic resident handled with stable methods of procedures the corneal donor procurement from 2009 to 2015. The rates of corneal donation were examined and analyzed. Among the 5712 hospital deaths, consent for corneal donation was obtained in 711 cases...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28726327/changing-metrics-of-organ-procurement-organization-performance-in-order-to-increase-organ-donation-rates-in-the-united-states
#8
D Goldberg, M J Kallan, L Fu, M Ciccarone, J Ramirez, P Rosenberg, J Arnold, G Segal, K P Moritsugu, H Nathan, R Hasz, P L Abt
The shortage of deceased-donor organs is compounded by donation metrics that fail to account for the total pool of possible donors, leading to ambiguous donor statistics. We sought to assess potential metrics of organ procurement organizations (OPOs) utilizing data from the Nationwide Inpatient Sample (NIS) from 2009-2012 and State Inpatient Databases (SIDs) from 2008-2014. A possible donor was defined as a ventilated inpatient death ≤75 years of age, without multi-organ system failure, sepsis, or cancer, whose cause of death was consistent with organ donation...
July 20, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28725172/an-original-and-effective-technique-to-improve-exposure-in-open-surgery
#9
E Nohuz, G Chêne
BACKGROUND: Exposure, especially when the organs are enlarged, remains one of the most important issue in open surgery. Considering this constraint appears critical in the progress of the surgical procedure. We highlight our technique which affords optimal exposure and improves manipulation and extraction of enlarged organs. RESULTS: This original and effective technique is derived from an obstetrical device used to perform an assisted vaginal delivery. It improves exposure, reduces tissue manipulation, and enhances removal of the surgical specimen during hysterectomies and myomectomies...
2017: Gynecological Surgery
https://www.readbyqxmd.com/read/28712678/impact-of-the-18th-birthday-on-waitlist-outcomes-among-young-adults-listed-for-heart-transplant-a-regression-discontinuity-analysis
#10
David M Peng, Qiuying Qu, Nancy McDonald, Seth A Hollander, Daniel Bernstein, Katsuhide Maeda, Beth D Kaufman, David N Rosenthal, Doff B McElhinney, Christopher S Almond
BACKGROUND: Patients listed for heart transplant after their 18th birthday purportedly wait longer to receive a donor heart compared with patients listed before their 18th birthday. It is unclear whether there is an actual difference in wait times and whether any difference in wait time is associated with lower likelihood of transplant and/or higher risk of mortality. METHODS: Organ procurement and transplant network data were used to identify all patients listed for heart transplant between 2006 and 2014 within a 1-year period before and after their 18th birthday...
May 19, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/28706975/reexamining-the-association-of-body-mass-index-with-overall-survival-outcomes-after-liver-transplantation
#11
Su-Hsin Chang, Xiaoyan Liu, Nils P Carlsson, Yikyung Park, Graham A Colditz, Jacqueline M Garonzik-Wang, William C Chapman, Jason R Wellen, Maria B Doyle, Tarek Alhamad
BACKGROUND: Several studies have shown that obese patients undergoing liver transplantation (LT) have an increased risk of mortality regardless of Model of End Stage Liver Disease (MELD) scores. The purpose of this study is to identify the range of body mass index (BMI) at LT associated with the lowest risks of posttransplant mortality by MELD category. METHODS: A retrospective cohort of patients aged 18 years or older from the Organ Procurement and Transplantation Network database undergoing LT between February 27, 2002, and December 31, 2013, was identified and followed up through March 14, 2014...
July 2017: Transplantation Direct
https://www.readbyqxmd.com/read/28695832/the-investigation-of-the-presence-of-mites-in-some-served-dry-foodstuffs
#12
Emel Uzunoğlu Karagöz, Cihangir Akdemir, Şahin Direkel, Nejla Cebeci Güler
OBJECTIVE: Mites are microscopic organisms that lower the quality of life of people who are sensitive to them by causing conditions such as atopic dermatitis, allergic rhinitis, and asthma. These organisms are found in every habitat where humans live. This study was conducted to determine the presence of storage mites in dry food items. METHODS: Various food items were procured 10 times each in 300-gram samples. Mites were extracted with a Berlese funnel apparatus over Erlenmeyer flasks containing 70% alcohol placed at the end of the funnel stems for over 48 h...
June 2017: Türkiye Parazitolojii Dergisi
https://www.readbyqxmd.com/read/28694422/development-of-graft-site-candidiasis-in-3-solid-organ-transplant-recipients-from-the-same-donor
#13
Nasrin El-Bandar, Daniela C Kroy, Tom Florian Fuller, Jürgen Kramer, Lutz Liefeldt, Klemens Budde, Conrad Blobel, Kurt Miller, Frank Friedersdorff
BACKGROUND Graft-site candidiasis rarely develops in solid organ transplant recipients; however, severe life-threatening complications can occur. We report the course of 3 solid organ transplant recipients developing graft-site candidiasis. CASE REPORT All grafts, consisting of 2 kidneys and 1 liver, were procured from a single donor. Patient data were collected from our database. Candida albicans was isolated from a swab taken during multiple-organ recovery. Complications associated with candidiasis occurred in all 3 recipients with preservation of the liver transplant...
July 11, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28694420/effect-of-organ-scandal-on-corneal-donation-rate-and-organ-donors-at-a-german-university-hospital
#14
Daniel Röck, Peter Petersen, Efdal Yoeruek, Sebastian Thaler, Karl Ulrich Bartz-Schmidt, Tobias Röck
BACKGROUND The purpose of this study was to assess the effect of an organ transplantation scandal on the rate of corneal donations and organ donors at the University Hospital Tübingen. MATERIAL AND METHODS Data from all hospital deaths from January 2012 to December 2013 were analyzed retrospectively. Each deceased patient was considered as a potential corneal donor. The corneal donor procurement was handled by an ophthalmic resident on a full-time basis with standard used unchanged set of procedures. Each patient who died due to cerebral complications was considered as a potential organ donor...
July 11, 2017: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/28684646/association-between-reperfusion-renal-allograft-biopsy-findings-and-transplant-outcomes
#15
Sumit Mohan, Eric Campenot, Mariana C Chiles, Dominick Santoriello, Eric Bland, R John Crew, Paul Rosenstiel, Geoffrey Dube, Ibrahim Batal, Jai Radhakrishnan, P Rodrigo Sandoval, James Guarrera, M Barry Stokes, Vivette D'Agati, David J Cohen, Lloyd E Ratner, Glen Markowitz
Biopsy findings at the time of procurement of deceased donor kidneys remain the most common reason cited for kidney discard. To determine the value of renal allograft histology in predicting outcomes, we evaluated the significance of histologic findings, read by experienced renal pathologists, in 975 postreperfusion biopsy specimens collected from 2005 to 2009 after living donor (n=427) or deceased donor (n=548) renal transplant. We evaluated specimens for the degree of glomerulosclerosis, interstitial fibrosis and tubular atrophy, and vascular disease; specimens with a score of 0 or 1 (scale, 0-3) for each parameter were considered optimal...
July 6, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28682445/evaluating-center-performance-in-the-competing-risks-setting-application-to-outcomes-of-wait-listed-end-stage-renal-disease-patients
#16
Sai H Dharmarajan, Douglas E Schaubel, Rajiv Saran
It is often of interest to compare centers or healthcare providers on quality of care delivered. We consider the setting where evaluation of center performance on multiple competing events is of interest. We propose estimating center effects through cause-specific proportional hazards frailty models that allow correlation among a center's cause-specific effects. Estimation of our model proceeds via penalized partial likelihood and is implemented in R. To evaluate center performance, we also propose a directly standardized excess cumulative incidence (ECI) measure...
July 6, 2017: Biometrics
https://www.readbyqxmd.com/read/28681316/donor-derived-candida-stellimalicola-in-a-clinical-specimen-preservation-fluid-contamination-during-pancreas-procurement
#17
Damien Dupont, Antoine Huguenin, Elodie Tisserand, Véronique Reiter, Emmanuel Morelon, Lionel Badet, Isabelle Villena, Martine Wallon, Dominique Toubas
We report here a case of possible donor-derived Candida stellimalicola infection after pancreas transplantation. Candida stellimalicola, an environmental non-filamentous yeast, was isolated from both the peritoneal fluid of the graft donor and the preservation fluid of the transplanted pancreas. Interestingly, this strain exhibited high minimum inhibitory concentrations to azoles. These results justified the use of echinocandins as therapy instead of fluconazole. This switch permitted a favorable outcome. To our knowledge, this is the first report of C...
July 5, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28670770/are-drowned-donors-marginal-donors-a-single-pediatric-center-experience
#18
Kayla R Kumm, N Thao N Galván, Sarah Koohmaraie, Abbas Rana, Michael Kueht, Katherine Baugh, Liu Hao, Dor Yoeli, Ronald Cotton, Christine A O'Mahony, John A Goss
Drowning, a common cause of death in the pediatric population, is a potentially large donor pool for OLT. Anecdotally, transplant centers have deemed these organs high risk over concerns for infection and graft dysfunction. We theorized drowned donor liver allografts do not portend worse outcomes and therefore should not be excluded from the donation pool. We reviewed our single-center experience of pediatric OLTs between 1988 and 2015 and identified 33 drowned donor recipients. These OLTs were matched 1:2 to head trauma donor OLTs from our center...
July 3, 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/28660162/keys-to-successful-organ-procurement-an-experience-based-review-of-clinical-practices-at-a-high-performing-health-care-organization
#19
REVIEW
Thomas R Wojda, Stanislaw P Stawicki, Kathy P Yandle, Maria Bleil, Jennifer Axelband, Rebecca Wilde-Onia, Peter G Thomas, James Cipolla, William S Hoff, Jill Shultz
Organ procurement (OP) from donors after brain death and circulatory death represents the primary source of transplanted organs. Despite favorable laws and regulations, OP continues to face challenges for a number of reasons, including institutional, personal, and societal barriers. This focused review presents some of the key components of a successful OP program at a large, high-performing regional health network. This review focuses on effective team approaches, aggressive resuscitative strategies, optimal communication, family support, and community outreach efforts...
April 2017: International Journal of Critical Illness and Injury Science
https://www.readbyqxmd.com/read/28658314/early-evidence-late-2nd-millennium-bce-of-plant-based-dyeing-of-textiles-from-timna-israel
#20
Naama Sukenik, David Iluz, Zohar Amar, Alexander Varvak, Vanessa Workman, Orit Shamir, Erez Ben-Yosef
In this article, we focus on the analysis of dyed textile fragments uncovered at an early Iron Age (11th-10th centuries BCE) copper smelting site during new excavations in the Timna Valley conducted by the Central Timna Valley (CTV) Project, as well as those found by the Arabah Expedition at the Hathor Temple (Site 200), dated to the Late Bronze/early Iron Ages (13th-11th centuries BCE). Analysis by HPLC-DAD identified two organic dyestuffs, Rubia tinctorum L. and indigotin, from a plant source (probably Isatis tinctoria L...
2017: PloS One
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