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https://www.readbyqxmd.com/read/29898586/the-challenges-of-providing-rehabilitation-for-patients-undergoing-sacrectomy-two-case-reports
#1
George J Francis, An Ngo-Huang, Laurence D Rhines, Eduardo Bruera
BACKGROUND: Sacral neoplasms often present as large masses that often require sacrectomy. Multiple sacral nerve roots may be compromised post-sacrectomy and postoperative complications may result in impaired mobility, pain, orthostasis, and neurogenic bowel and bladder. CASE REPORTS: CASE #1: 58 year-old female with a sacral solitary fibrous tumor underwent a high-level sacrectomy and bilateral gluteal muscle flaps. Her rehabilitation course included management of pain, orthostasis, and neurogenic bowel and bladder...
June 11, 2018: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/29848671/the-colorful-palette-of-neuroendocrine-neoplasms-in-the-genitourinary-tract
#2
REVIEW
Boglárka Pósfai, Levente Kuthi, Linda Varga, Ibolya Laczó, János Révész, Réka Kránicz, Anikó Maráz
BACKGROUND: Neuroendocrine neoplasms include a heterogeneous group of malignant tumors. Primary neuroendocrine tumors in the genitourinary tract are rare, comprising approximately 1-2% of genitourinary malignancies. MATERIALS AND METHODS: An extensive search was performed for publications between 2000 and 2018 regarding neuroendocrine tumors of the genitourinary tract. Epidemiological, clinical, histopathological, prognostic and therapeutic data were evaluated. RESULTS: Neuroendocrine tumors of the kidneys are exceedingly rare, mostly well-differentiated...
June 2018: Anticancer Research
https://www.readbyqxmd.com/read/29805657/clinicopathological-analysis-of-epithelioid-inflammatory-myofibroblastic-sarcoma
#3
Xuemei Du, Ying Gao, Hongyu Zhao, Bin Li, Weimin Xue, Daye Wang
Inflammatory myofibroblastic tumor (IMT) is a distinctive neoplasm composed of myofibroblastic and fibroblastic spindle cells, accompanied by the inflammatory infiltration of plasma cells, lymphocytes and/or eosinophils. Epithelioid inflammatory myofibroblastic sarcoma (EIMS), which primarily consists of cells with a round or epithelioid morphology, is associated with a poor prognosis and rapid development of local recurrence, and has been recognized to be a variant of IMT. Diagnosis of EIMS is difficult owing to its close resemblance to malignant mesothelioma, anaplastic large cell lymphoma, gastrointestinal stromal tumor and other malignant diseases...
June 2018: Oncology Letters
https://www.readbyqxmd.com/read/29796007/b-chronic-lymphocytic-leukemia-showed-triple-transformation-to-diffuse-large-b-cell-cd20-negative-and-t-cell-neoplasm-during-ofatumumab-treatment-a-case-report
#4
Osamu Imataki, Makiko Uemura
Background: Chronic lymphocytic leukemia (CLL) is a mature lymphoid neoplasm currently categorized as an indolent type of malignant lymphoma. CLL progresses slowly over years, but it eventually transforms to a more aggressive lymphoma such as the diffuse large B-cell (DLBCL) type, also known as Richter's syndrome. Case presentation: We treated a 69-year-old Japanese male who was histologically diagnosed with Richter's syndrome after 6 years of CLL. His lymphadenopathy had systemically progressed for years, with lymphocyte counts of less than 10,000 cells/μL and a disease status of Rai classification stage I and Binet classification B...
2018: BMC Clinical Pathology
https://www.readbyqxmd.com/read/29764851/inflammatory-myofibroblastic-tumour-an-unusual-presentation-including-small-bowel-obstruction-and-palpable-abdominal-mass
#5
Emily Cerier, Eliza Wright Beal, Mary E Dillhoff
A 41-year-old man with no medical history presented with 2 weeks of nausea, vomiting, a new palpable abdominal mass, constipation and a 14kgweight loss. On admission, CT abdomen and pelvis demonstrated a 6.9×3.7 cm soft-tissue abdominal mass deep to and invading the lower anterior abdominal wall with tethering of the urinary bladder and potential involvement of the urachus. Subsequently, a biopsy demonstrated a low-grade spindle cell neoplasm compatible with inflammatory myofibroblastic tumour with immunostain positive for smooth muscle actin and desmin and negative for CD21, CD117, DOG-1, TKE-1, mdm2, CD34 and ALK...
May 15, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29751789/mechanisms-of-immune-evasion-in-breast-cancer
#6
Joshua P Bates, Roshanak Derakhshandeh, Laundette Jones, Tonya J Webb
Tumors develop multiple mechanisms of immune evasion as they progress, with some cancer types being inherently better at 'hiding' than others. With an increased understanding of tumor immune surveillance, immunotherapy has emerged as a promising treatment strategy for breast cancer, despite historically being thought of as an immunologically silent neoplasm. Some types of cancer, such as melanoma, bladder, and renal cell carcinoma, have demonstrated a durable response to immunotherapeutic intervention, however, breast neoplasms have not shown the same efficacy...
May 11, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29736308/spocd1-promotes-the-proliferation-and-metastasis-of-glioma-cells-by-up-regulating-ptx3
#7
Quan Liu, Xiao-Yu Wang, Yuan-Yuan Qin, Xian-Lei Yan, Hong-Mou Chen, Qi-Dan Huang, Jia-Kang Chen, Jie-Min Zheng
Gliomas are the most prevalent type of primary brain tumors in adults, accounting for more than 40% of neoplasms in the central nervous system. The spen paralogue and orthologue C-terminal domain containing 1 (SPOCD1) has been recently identified and found to discriminate progressive from non-progressive bladder cancers. In this study, we detected high-level of SPOCD1 expression in glioma and its high expression significantly associated with advanced tumor grade and poor prognosis. In vitro assays showed that knockdown of SPOCD1 significantly inhibited cell proliferation and colony formation capacities in U373 and U87 cells...
2018: American Journal of Cancer Research
https://www.readbyqxmd.com/read/29732388/systematic-review-characteristics-and-preclinical-uses-of-bladder-cancer-cell-lines
#8
Tahlita C M Zuiverloon, Florus C de Jong, James C Costello, Dan Theodorescu
Background: Bladder cancer (BC) cell lines are indispensable in basic and preclinical research. Currently, an up-to-date and comprehensive overview of available BC cell lines is not available. Objective: To provide an overview and resources on the origin, pathological and molecular characteristics of commonly used human, murine and canine BC cell lines. Methods: A PubMed search was performed for relevant articles published between 1980 and 2017 according to the following MeSH terms: cell line; cell line, tumor; urinary bladder neoplasms; carcinoma, transitional cell...
April 26, 2018: Bladder Cancer
https://www.readbyqxmd.com/read/29719336/study-of-proliferating-cell-nuclear-antigen-expression-and-angiogenesis-in-urothelial-neoplasms-correlation-with-tumor-grade-and-stage
#9
Poojan Agarwal, Achin Kumar Sen, Minakshi Bhardwaj, Veronique Dinand, Arvind Ahuja, Rajeev Sood
Background: Urinary bladder carcinoma ranks ninth in worldwide cancer incidence. About 74,000 new cases were diagnosed in 2015 alone and 16,000 persons died of the disease. Since histopathology is considered gold standard for diagnosis, it is prudent to look for potential tumor proliferation and predictive markers in such a prevalent malignancy so as to alert surgical and medical oncologists for timely intervention and provide better patient-tailored therapy. Aims: This study is to analyze the role of potential biomarkers-proliferating cell nuclear antigen (PCNA) and angiogenesis using CD31 in urothelial neoplasms in relation to tumor grade and stage...
April 2018: Urology Annals
https://www.readbyqxmd.com/read/29701416/co-existence-of-abdominal-aortic-aneurysm-with-urologic-neoplasm-which-should-be-treated-first-in-the-endovascular-era
#10
José Oliveiar-Pinto, Nilo Mosquera, José Vidoedo, Sérgio Moreira-Sampaio, José Teixeira
INTRODUCTION: Prevalence of Abdominal Aortic Aneurysm (AAA) with concomitant malignancy rounds 3-13%. Considering only urological neoplasms the prevalence is around 3.6%. Survival at 5 years of bladder carcinoma without extravesical invasion (stage II) rounds 63%. Endovascular Aneurysm Repair (EVAR), due to its minimally invasive profile, is an option for treatment of AAA prior to urological surgery as it does not require laparotomy not conditioning the delay of oncologic surgery. METHODS: Male, 62 years old...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29628616/updates-on-uterine-artery-embolization
#11
REVIEW
Maureen P Kohi, James B Spies
Uterine fibroids (leiomyomas) are the most common benign neoplasm of the female pelvis and have a lifetime prevalence exceeding 80% among African American women and approaching 70% among Caucasian women. Approximately 50% of women with fibroids experience symptoms which may include menorrhagia that may result in anemia, bulk symptoms with bladder and bowel dysfunction and abdominal protrusion, dysmenorrhea, and infertility. Hysterectomy remains the most common treatment option for fibroids and concerns have been raised about the overuse of this procedure...
March 2018: Seminars in Interventional Radiology
https://www.readbyqxmd.com/read/29624571/frequency-and-characteristics-of-gallbladder-cancer-at-a-referral-hospital-in-southern-peru-2009-2014-a-descriptive-study
#12
Tessy Tairo-Cerron, Richar Paredes-Orue, Oscar Moreno-Loaiza
INTRODUCTION: Gallbladder cancer is a rare neoplasm, its frequency is variable in the regions of Peru. OBJECTIVE: To determine the frequency and describe the clinical characteristics of gallbladder cancer in southern Peru. METHODS: The reports of the anatomopathological department of the Honorio Delgado Regional Hospital were selected from all samples of cholecystectomies performed between 2009 and 2014 and those that had some result compatible with gallbladder cancer were looked for...
March 26, 2018: Medwave
https://www.readbyqxmd.com/read/29593873/post-transplant-lymphoproliferative-disorder-of-the-bladder-in-a-lung-transplant-recipient
#13
Harpreet Singh Grewal, Charles Lane, Kristin B Highland, Olufemi Akindipe, Marie Budev, Atul C Mehta
Post-transplant lymphoproliferative disorder (PTLD) occurs in ~5% of solid organ and hematopoietic stem cell transplant recipients. We report a unique presentation of PTLD in the bladder of a lung transplant recipient. Our patient was a 62-year-old female who received a bilateral lung transplant for chronic obstructive pulmonary disease. She presented with fever, left-sided flank pain and foul-smelling urine consistent with urosepsis. An abdominal and pelvic computerized tomography revealed an irregular and nodular bladder wall thickening suspicious for urothelial neoplasm...
March 2018: Oxford Medical Case Reports
https://www.readbyqxmd.com/read/29568660/a-case-of-early-stage-bladder-carcinosarcoma-in-late-recurrence-of-urothelial-carcinoma-after-transurethral-resection
#14
Daisaku Hirano, Toshiyuki Yoshida, Daigo Funakoshi, Fuminori Sakurai, Shou Ohno, Yoshiaki Kusumi
Carcinosarcomas of the urinary bladder are rare biphasic neoplasms, consisting of both malignant epithelial and malignant mesenchymal components, and the prognosis of this tumor is unfavorable in most patients with even possibility of resection of disease. A 77-year-old male with a history of transurethral resection (TUR) of urothelial carcinoma (UC) of the bladder and adjuvant intravesical chemotherapy with pirarubicin 10 years ago revisited our department with a gross hematuria. Cystoscopy demonstrated an approximately 2...
2018: Case Reports in Urology
https://www.readbyqxmd.com/read/29557778/non-invasive-detection-of-urothelial-cancer-through-the-analysis-of-driver-gene-mutations-and-aneuploidy
#15
Simeon U Springer, Chung-Hsin Chen, Maria Del Carmen Rodriguez Pena, Lu Li, Christopher Douville, Yuxuan Wang, Joshua David Cohen, Diana Taheri, Natalie Silliman, Joy Schaefer, Janine Ptak, Lisa Dobbyn, Maria Papoli, Isaac Kinde, Bahman Afsari, Aline C Tregnago, Stephania M Bezerra, Christopher VandenBussche, Kazutoshi Fujita, Dilek Ertoy, Isabela W Cunha, Lijia Yu, Trinity J Bivalacqua, Arthur P Grollman, Luis A Diaz, Rachel Karchin, Ludmila Danilova, Chao-Yuan Huang, Chia-Tung Shun, Robert J Turesky, Byeong Hwa Yun, Thomas A Rosenquist, Yeong-Shiau Pu, Ralph H Hruban, Cristian Tomasetti, Nickolas Papadopoulos, Ken W Kinzler, Bert Vogelstein, Kathleen G Dickman, George J Netto
Current non-invasive approaches for detection of urothelial cancers are suboptimal. We developed a test to detect urothelial neoplasms using DNA recovered from cells shed into urine. UroSEEK incorporates massive parallel sequencing assays for mutations in 11 genes and copy number changes on 39 chromosome arms. In 570 patients at risk for bladder cancer (BC), UroSEEK was positive in 83% of those who developed BC. Combined with cytology, UroSEEK detected 95% of patients who developed BC. Of 56 patients with upper tract urothelial cancer, 75% tested positive by UroSEEK, including 79% of those with non-invasive tumors...
March 20, 2018: ELife
https://www.readbyqxmd.com/read/29536021/small-cell-carcinoma-of-prostate-a-case-report-of-a-patient-with-concomitant-transitional-cell-cancer-of-the-bladder
#16
Waiel Abusnina, Eric Yiman Auyoung, Mohammed Megri, Toni Pacioles
Small cell carcinomas (SCCs) are aggressive neoplasms commonly associated with a pulmonary origin. However, albeit rare, extrapulmonary SCC can occur in a variety of sites with an incidence in North America approximated to be 0.1% to 0.4%. Among these sites, approximately 10% of extrapulmonary SCC cases occur in the prostate and are associated with a poor mortality with a median survival of 10 months. Because of the rarity of the prostatic SCC, there is no formal treatment protocol. In this case report, we present a patient who was diagnosed with SCC in the prostate as primary origin...
January 2018: Journal of Investigative Medicine High Impact Case Reports
https://www.readbyqxmd.com/read/29535991/pulmonary-inflammatory-myofibroblastic-tumor-in-children-a-case-report-and-brief-review-of-literature
#17
Federica Camela, Marcella Gallucci, Emanuela di Palmo, Salvatore Cazzato, Mario Lima, Giampaolo Ricci, Andrea Pession
The inflammatory myofibroblastic tumor (IMT) is a rare lesion of unclear etiology and variable clinical course, consisting of a proliferation of fibroblasts and myofibroblasts, mixed with inflammatory cells. Synonyms of IMT are inflammatory pseudotumor and plasma cell granuloma reflecting the alleged inflammatory nature attributed to this lesion, even though this heterogeneity in the disease denomination is probably involved in a dispersion of the literature data. Among primary pulmonary neoplasms, it represents the most frequent endobronchial tumor of childhood and beyond the lung it has been described mainly in the bladder, mediastinum and mesentery...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29535424/comprehensive-genomic-profiling-of-neuroendocrine-bladder-cancer-pinpoints-molecular-origin-and-potential-therapeutics
#18
Peiye Shen, Ying Jing, Ruiyun Zhang, Mei-Chun Cai, Pengfei Ma, Haige Chen, Guanglei Zhuang
Neuroendocrine bladder cancer is a relatively rare but often lethal malignancy, with cell of origin, oncogenomic architecture and standard treatment poorly defined. Here we performed comprehensive whole-genome and transcriptome sequencing on a unique cohort of genitourinary neuroendocrine neoplasms, mainly small cell carcinomas of the urinary bladder. The mutational landscape and signatures of neuroendocrine bladder cancer strikingly resembled those in conventional urothelial carcinoma, along with typically mixed histologies, supporting a common cellular origin...
March 14, 2018: Oncogene
https://www.readbyqxmd.com/read/29531006/tfe3-expressing-epithelioid-rich-perivascular-epithelioid-cell-neoplasm-pecoma-of-the-bladder-with-unusual-benign-course
#19
Xiu Fen Chen, Joe Yeong, Kenneth Tou En Chang, Alvin Soon Tiong Lim, Chik Hong Kuick, Tse Hui Lim, Jain Sudhanshi, Sathiyamoorthy Selvarajan, Valerie Huei Li Gan, Li Yan Khor
Perivascular epithelioid cell tumor (PEComa) is an uncommon tumor which presents with epithelioid and spindled cell morphology and is immunoreactive for myogenic and melanocytic markers. Recently, a subset of PEComas has been reported to harbor TFE3 gene rearrangement.In this case report, we describe a TFE3 -expressing primary bladder PEComa in a 27-year-old male patient with acute myeloid leukaemia in remission. The tumor displayed epithelioid morphology with surrounding delicate blood vessels and was devoid of a prominent spindle cell component...
January 2018: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/29524371/inequalities-in-cancer-deaths-by-age-gender-and-education
#20
Marek Gróf, Tatiana Vagašová, Marián Oltman, Ľubomír Skladaný, Lenka Maličká
AIM: The economy of each state provides a significant amount of money into the health care system with the aim of knowing the health status of its population in the context of socioeconomic characteristics for effective resource allocation. In recent years, there is a growing number of cancer deaths in Slovakia. Therefore, the structure of cancer deaths according to its primary determinants, such as age, sex and education with the aim of effective implementation of prevention programs in Slovakia was examined...
December 2017: Central European Journal of Public Health
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