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https://www.readbyqxmd.com/read/28525424/metastatic-melanoma-with-papillary-features-a-mimic-and-possible-diagnostic-pitfall
#1
Alberto Valero-Torres, Victor G Prieto, Priyadharsini Nagarajan, Carlos A Torres-Cabala, Michael T Tetzlaff, Jonathan L Curry, Doina Ivan, Phyu P Aung
Papillary and pseudopapillary features are histopathologic findings typically associated with carcinomas (thyroid, pancreas, breast, prostate, bladder, kidney, or ovary) or mesothelioma. Melanoma is typically composed of nested and variably pigmented atypical cells. Here, we report a case of in-transit metastasis of melanoma presenting with prominent papillary features, and we discuss the differential diagnoses of neoplasms with papillary features. This case report suggests that the spectrum of neoplasms with papillary features should be expanded to include melanoma, a pattern that, to the best of our knowledge, is uncommon...
June 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28522928/systematic-review-of-open-versus-laparoscopic-versus-robot-assisted-nephroureterectomy
#2
Emma Mullen, Kamran Ahmed, Ben Challacombe
Upper tract urothelial carcinoma is a relatively uncommon malignancy. The gold standard treatment for this type of neoplasm is an open radical nephroureterectomy with excision of the bladder cuff. This systematic review compares the perioperative and oncologic outcomes for the open surgical method with the alternative surgical management options of laparoscopic nephroureterectomy and robot-assisted nephroureterectomy (RANU). MEDLINE, EMBASE, PubMed, and Cochrane Library databases were searched using a sensitive search strategy...
2017: Reviews in Urology
https://www.readbyqxmd.com/read/28515817/systematic-review-of-the-potential-role-of-cannabinoids-as-antiproliferative-agents-for-urological-cancers
#3
REVIEW
Shreyas Gandhi, Gaurav Vasisth, Anil Kapoor
INTRODUCTION: The palliative effects of cannabis sativa (marijuana), which include appetite stimulation, attenuation of nausea and emesis, and pain relief, are well known. The active components of cannabis sativa (cannabinoids) and their derivatives have received growing interest due to their diverse pharmacological activities, such as cell growth inhibition and tumour regression. The aim of this review is to look at the current evidence on the antiproliferative effects of cannabinoids in urological malignancies, including renal, prostate, bladder, and testicular cancers...
March 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28511402/bladder-adenocarcinoma-a-persisting-diagnostic-dilemma
#4
Geetha Vasudevan, Arijit Bishnu, Brij Mohan Kumar Singh, Deepak M Nayak, Pooja Jain
Primary urinary Bladder Adenocarcinoma (PBA) is an uncommon neoplasm and can cause diagnostic difficulties due to histologic similarities with adenocarcinomas of adjacent structures like Gastrointestinal Tract (GIT) and prostate, since involvement of the bladder by metastasis or direct spread can occur. Seven cases of bladder adenocarcinomas were diagnosed during a period of four years in a tertiary care hospital. Patient's age ranged from 26-78 years with a male predilection. Three cases were signet ring type adenocarcinomas, two cases were subtyped as enteric variant, one as mucinous variant and one as adenocarcinoma Not Otherwise Specified (NOS) variant...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28502834/a-rare-case-of-intravesical-angiomyofibroblastoma
#5
Phanindra Mohan Deka, Jaynil A Bagawade, Pallavi Deka, Ronica Baruah, Naushad Shah
OBJECTIVES: To study the first reported case of intravesical Angiomyofibroblastoma (AMFB). AMFB is an uncommon benign mesenchymal lesion, mostly described in the lower female genital tract, especially in the vulva and less commonly the vagina. It is rarely seen in the male genital tract. The importance of this rare neoplasm is related to its potential mimicry of more infiltrative and prognostically less favorable lesions, such as aggressive angiomyxomas, that are found in the same anatomic area...
May 11, 2017: Urology
https://www.readbyqxmd.com/read/28494807/concordant-clear-cell-mesonephric-carcinoma-of-the-bladder-and-lung-adenocarcinoma-with-clear-cell-features-multiple-primaries-versus-metastatic-neoplasms-a-case-report
#6
Sarmad H Jassim, Amer Khiyami, Jane K Nguyen, Santhi Ganesan, Joseph Tomashefski, Joram Sawady
BACKGROUND: Clear cell carcinoma of the bladder is a rare variant of urinary bladder adenocarcinoma. We report a case of a patient with clear cell carcinoma of the bladder and a concordant right upper lobe pulmonary adenocarcinoma with clear cell features, and we address the role of immunohistochemistry and cytogenetic analysis in distinguishing the two primary malignancies. CASE PRESENTATION: Our patient was a 59-year-old African American woman who presented with hematuria...
May 12, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28469300/bladder-cancer-micro-rnas-as-biomolecules-for-prognostication-and-surveillance
#7
REVIEW
Nilay Mitash, Swasti Tiwari, Shalini Agnihotri, Anil Mandhani
INTRODUCTION: Bladder cancer (BC) has varied clinical behavior in terms of recurrence and progression. Current pathological characteristics are insufficient to prognosticate the outcome of a given treatment. Cellular metabolic regulatory molecules, such as micro RNA (miRNA), could be a potential biomarker to prognosticate the treatment outcomes. MATERIALS AND METHODS: PubMed and Google Scholar databases were searched for publications from 1990 to 2016, related to miRNA biogenesis, its function, and role in the pathogenesis of bladder as well as other cancers...
April 2017: Indian Journal of Urology: IJU: Journal of the Urological Society of India
https://www.readbyqxmd.com/read/28449606/pseudomyxoma-peritonei-as-a-first-manifestation-of-kras-mutated-urachal-mucinous-cystadenocarcinoma-of-the-bladder-a-case-report
#8
Ksenya V Shelekhova, Alexander S Zhuravlev, Daria D Krylova, Alexey S Konstantinov, Lidia V Shtan, Valeriia A Kheinshtein
Only 28 cases of pseudomyxoma peritonei (PMP) arising from urachal neoplasms have been reported. We report one example of this extremely rare disease with KRAS mutational status in its spectrum of pathology. A 45-year-old woman presented with urachal frankly invasive mucinous cystadenocarcinoma confined to the dome of the bladder, which clinically manifested as PMP and was not detected at the first surgery. The primary tumour was revealed 6 months later because of its recurrence as PMP. Microscopic investigation revealed tubular adenoma and cystadenocarcinoma communicating with the bladder lumen and transitioning from the urachal urothelium to the mucinous epithelium...
April 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28430636/exploring-the-role-of-paraoxonase-2-in-bladder-cancer-analyses-performed-on-tissue-samples-urines-and-cell-cultures
#9
Tiziana Bacchetti, Davide Sartini, Valentina Pozzi, Tiziana Cacciamani, Gianna Ferretti, Monica Emanuelli
The enzyme paraoxonase-2 (PON2) is ubiquitously expressed and exerts its antiapoptotic and antioxidative functions in several intracellular compartments.The aim of this study is to investigate the role of PON2 in bladder cancer (BC). The expression levels of PON2 in paired tumor and normal bladder tissue samples and in urinary exfoliated cells from patients affected with BC and healthy donors were evaluated. Moreover, the effect of PON2 overexpression on tumor cell proliferation and susceptibility to oxidative stress was investigated in human bladder cancer cell line T24...
April 25, 2017: Oncotarget
https://www.readbyqxmd.com/read/28418878/the-tert-rs2736100-polymorphism-increases-cancer-risk-a-meta-analysis
#10
Hui Li, Yanyan Xu, Hua Mei, Liang Peng, Xiaojie Li, Jianzhou Tang
Abnormal telomerase activity is implicated in cancer initiation and development. The rs2736100 T > G polymorphism in the telomerase reverse transcriptase (TERT) gene, which encodes the telomerase catalytic subunit, has been associated with increased cancer risk. We conducted a meta-analysis to more precisely assess this association. After a comprehensive literature search of the PubMed and EMBASE databases up to November 1, 2016, 61 articles with 72 studies comprising 108,248 cases and 161,472 controls were included in our meta-analysis...
March 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/28418346/extra-gastrointestinal-stromal-tumor-of-prostate
#11
Demet Etit, Haldun Kar, Neşe Ekinci, Ahmet Emre Yenipazar, Fulya Çakalağaoğlu
BACKGROUND: Extra-gastrointestinal stromal tumor is defined as a mesenchymal neoplasm arising from soft tissues outside the gastrointestinal tract. Prostatic extra-gastrointestinal stromal tumor has rarely been noted. CASE REPORT: A 56 year-old man presented with pain in the anal region. A digital rectal examination revealed that the prostate was markedly enlarged with a smooth, bulging surface. Computerized tomography images showed a 6 cm heterogeneous, infiltrative tumor within the prostate gland extending to the trigon of the bladder, left seminal vesicle and rectum...
April 5, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28406781/bladder-leiomyoma
#12
Selahattin Caliskan, Mustafa Sungur
Leiomyoma of the bladder is a very rare disorder that accounts for 0.43% of all bladder neoplasms. Although the pathophysiology of the bladder leiomyoma is unknown, there are some theories in it. The patients can be asymptomatic; and clinical symptoms, when present, are associated with the tumor size and location. Imaging techniques such as ultrasonography, intravenous urography, computed tomography, and magnetic resonance imaging are helpful but definitive diagnosis is made by histopathological examination...
March 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28386678/identification-of-novel-potential-genetic-predictors-of-urothelial-bladder-carcinoma-susceptibility-in-pakistani-population
#13
Syeda Hafiza Benish Ali, Kashif Sardar Bangash, Abdur Rauf, Muhammad Younis, Khursheed Anwar, Raja Khurram, Muhammad Athar Khawaja, Maleeha Azam, Abid Ali Qureshi, Saeed Akhter, Lambertus A Kiemeney, Raheel Qamar
Urothelial bladder carcinoma (UBC) is the most common among urinary bladder neoplasms. We carried out a preliminary study to determine the genetic etiology of UBC in Pakistani population, for this 25 sequence variants from 17 candidate genes were studied in 400 individuals by using polymerase chain reaction-based techniques. Multivariate logistic regression analysis was performed for association analysis of the overall data as well as the data stratified by smoking status, tumor grade and tumor stage. Variants of GSTM1, IGFBP3, LEPR and ACE were found to be associated with altered UBC risk in the overall comparison...
April 6, 2017: Familial Cancer
https://www.readbyqxmd.com/read/28375528/makroskopisk-hematuri-vid-behandling-med-noak-incidensen-%C3%A3-r-l%C3%A3-g-%C3%A2-snar-urologisk-utredning-kr%C3%A3-vs-visar-retrospektiv-studie-vid-hj%C3%A3-rtspecialistmottagning
#14
Faris Al Khalili
Incidence, investigation and long-term follow-up of macroscopic hematuria in patients treated with non vitamin K antagonist oral anticoagulant: Insight from a specialist cardiology clinic In a retrospective long-term follow up of patients with non-valvular atrial fibrillation treated with non-vitamin K dependent oral anticoagulants in a specialist clinic, the incidence of reported macroscopic hematuria was relatively low and none of these was major bleeding. Urgent investigation of the bleeding source by a urologist showed different etiologies, like newly discovered neoplasm, benign hyperplasia of the prostate gland, renal stones, or inflammatory changes in the urinary bladder, and some had normal findings...
March 31, 2017: Läkartidningen
https://www.readbyqxmd.com/read/28330811/association-between-twelve-polymorphisms-in-five-x-ray-repair-cross-complementing-genes-and-the-risk-of-urological-neoplasms-a-systematic-review-and-meta-analysis
#15
Meng Zhang, Wanzhen Li, Zongyao Hao, Jun Zhou, Li Zhang, Chaozhao Liang
Polymorphisms in X-ray repair cross-complementing (XRCC) genes have been implicated in altering the risk of various urological cancers. However, the results of reported studies are controversial. To ascertain whether polymorphisms in XRCC genes are associated with the risk of urological neoplasms, we conducted present updated meta-analysis and systematic review. Summary odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were used to estimate the association. Finally, 54 publications comprising 129 case-control studies for twelve polymorphisms in five XRCC genes were enrolled...
April 2017: EBioMedicine
https://www.readbyqxmd.com/read/28321395/detection-of-intratumor-heterogeneity-in-modern-pathology-a-multisite-tumor-sampling-perspective
#16
Jesús M Cortés, Giovanni de Petris, José I López
Current sampling protocols of neoplasms along the digestive tract and in the urinary bladder have to be updated, as they do not respond to the necessities of modern personalized medicine. We show here that an adapted version of multisite tumor sampling (MSTS) is a sustainable model to overcome current deficiencies in digestive and bladder tumors when they are large enough so as to make unaffordable a total sampling. The new method is based on the divide-and-conquer algorithm and includes a slight modification of the MSTS, which proved to be useful very recently in clear cell renal cell carcinoma...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28315623/a-case-report-of-cholinergic-crisis-evolved-from-myasthenia-gravis-due-to-the-tumor-in-trigone-of-bladder
#17
Jingyao Liu, Xuemin Feng, Min Li, Teng Zhao
Cholinergic crisis has rarely been reported as a complication of myasthenia gravis, wherein it mainly occurs as a result of the improper accumulation of anticholinesterase agents. In this report, we present one such case. The nature of the patient's clinical manifestations suggested that the main reason for the cholinergic crisis was the abnormal accumulation of pyridostigmine bromide due to renal failure, which was secondary to a tumor in trigeon of bladder. To the best of our knowledge, this is the first report of myasthenia gravis leading to cholinergic crisis caused by acute postrenal renal failure arising from the bladder neoplasm...
November 2016: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/28314541/risk-of-subsequent-primary-kidney-cancer-after-another-malignancy-a-population-based-study
#18
Omar Abdel-Rahman
BACKGROUND: Population-based data on the development of kidney cancer as a second malignant neoplasm following the diagnosis of other common malignancies are rare. This clinical scenario has been evaluated within the Surveillance, Epidemiology, and End Results (SEER) database. MATERIALS AND METHODS: The SEER-9 database (1973-2013) was queried using the SEER*Stat program to determine the standardized incidence ratios (SIRs) of kidney cancer development following each one of 10 common invasive malignancies (colorectal, breast, prostate, lung, thyroid, corpus uteri, urinary bladder, kidney/renal pelvis, cutaneous melanoma, and non-Hodgkin lymphoma)...
February 27, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28299758/seventy-year-old-man-with-large-bladder-mass-diagnostic-and-clinical-challenges-of-an-uncommon-neoplasm
#19
Tamara P Lhungay, Alexandra Colvin, Jason Warncke, Hilary Somerset, Shandra S Wilson, Francisco G La Rosa
No abstract text is available yet for this article.
March 15, 2017: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/28288025/coffee-and-cancer-risk-a-summary-overview
#20
Gianfranco Alicandro, Alessandra Tavani, Carlo La Vecchia
We reviewed available evidence on coffee drinking and the risk of all cancers and selected cancers updated to May 2016. Coffee consumption is not associated with overall cancer risk. A meta-analysis reported a pooled relative risk (RR) for an increment of 1 cup of coffee/day of 1.00 [95% confidence interval (CI): 0.99-1.01] for all cancers. Coffee drinking is associated with a reduced risk of liver cancer. A meta-analysis of cohort studies found an RR for an increment of consumption of 1 cup/day of 0.85 (95% CI: 0...
March 10, 2017: European Journal of Cancer Prevention
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