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https://www.readbyqxmd.com/read/28064545/androgen-receptor-activation-a-prospective-therapeutic-target-for-bladder-cancer
#1
Taichi Mizushima, Kathleen A Tirador, Hiroshi Miyamoto
Patients with non-muscle-invasive or muscle-invasive bladder cancer undergoing surgery and currently available conventional therapy remain having a high risk of tumor recurrence or progression, respectively. Novel targeted molecular therapy is therefore expected to improve patient outcomes. Meanwhile, substantially higher incidence of bladder cancer in men has prompted research on androgen-mediated androgen receptor (AR) signaling in this malignancy. Indeed, preclinical evidence has suggested that AR signaling plays an important role in urothelial carcinogenesis and tumor outgrowth as well as resistance to some of the currently available conventional non-surgical therapies...
January 9, 2017: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/28039349/primary-embryonal-rhabdomyosarcoma-of-the-liver
#2
Aditi Arora, Ritika Jaiswal, Nidhi Anand, Nuzhat Husain
Rhabdomyosarcomas are malignant neoplasms with striated muscle differentiation. This is the most common type of soft-tissue sarcoma in children, but occurs rarely in adults. Its occurrence in liver is infrequent. We report a case of primary hepatic embryonal rhabdomyosarcoma in a 67-year-old man. The tumour was occupying the left lobe of the liver with large component of lesion seen bulging in left subhepatic space indenting over the stomach, compressing the pancreas and gall bladder. A percutaneous biopsy was performed which revealed embryonal rhabdomyosarcoma...
December 30, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/28012770/intracavitary-bacillus-calmette-guerin-in-the-treatment-of-superficial-bladder-tumors
#3
A Morales, D Eidinger, A W Bruce
Patients with recurrent superficial bladder tumors have been treated by vesical and intradermal administration of Bacillus Calmette-Guerin. The pattern of recurrence in 9 patients has been altered favorably. Although the findings are still preliminary they appear to hold promise of a new therapeutic approach to the treatment of a group of neoplasms for which effective therapy is still lacking.
December 21, 2016: Journal of Urology
https://www.readbyqxmd.com/read/28009239/central-nervous-system-filariasis-masquerading-as-a-glioma-case-report
#4
Adesh Shrivastava, Prateek Arora, Akriti Khare, Garima Goel, Neelkamal Kapoor
Filariasis, an endemic zoonosis in the Southeast Asia region, has been reported to affect various organs as well as the central nervous system (CNS). Inflammatory reactions mimicking those from neoplastic lesions clinically and radiologically have been reported in the breast and urinary bladder. To date, a CNS manifestation of filarial infestation has been reported in the form of meningoencephalitis. The authors here present an interesting case of a young man presenting in status epilepticus, which on radiological evaluation appeared to be a glioma...
December 23, 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28001329/fna-biopsy-of-secondary-nonlymphomatous-malignancies-in-salivary-glands-a-multi-institutional-study-of-184-cases
#5
He Wang, Raza S Hoda, William Faquin, Esther Diana Rossi, Nihar Hotchandani, Tianlin Sun, Marc Pusztaszeri, Tommaso Bizzarro, Massimo Bongiovanni, Viren Patel, Nirag Jhala, Guido Fadda, Yun Gong
BACKGROUND: Secondary malignancies of salivary glands (SMSGs) are among the most common malignant neoplasms to involve the salivary glands. Fine-needle aspiration biopsy (FNAB) of SMSG can present diagnostic challenges. The current report presents the largest such FNAB series to date. METHODS: A search of the pathology database from 6 academic institutions identified 184 FNAB cases of nonlymphomatous SMSG. RESULTS: Of the 184 cases, 171 were of the parotid glands, and 13 were of the submandibular glands; 130 patients were men, and 54 were women, and the mean patient age at diagnosis was 68 years...
December 21, 2016: Cancer
https://www.readbyqxmd.com/read/27999595/seborrheic-keratoses-as-the-first-sign-of-bladder-carcinoma-case-report-of-leser-tr%C3%A3-lat-sign-in-a-rare-association-with-urinary-tract-cancer
#6
Aline Stollmeier, Bernardo Augusto Rosario, Bruna Loise Mayer, Gibran Avelino Frandoloso, Francisco Luiz Gomide Mafra Magalhães, Gustavo Lenci Marques
Introduction. Skin disorders can be the first manifestation of occult diseases. The recognition of typical paraneoplastic dermatoses may anticipate the cancer diagnosis and improve its prognosis. Although rarely observed, the sudden appearance and/or rapid increase in number and size of seborrheic keratoses can be associated with malignant neoplasms, known as the sign of Leser-Trélat. The aim of this report is to unveil a case of a patient whose recently erupted seborrheic keratoses led to investigation and consequent diagnosis of bladder cancer...
2016: Case Reports in Medicine
https://www.readbyqxmd.com/read/27991416/small-cell-carcinoma-of-the-bladder-20-year-single-institution-retrospective-review
#7
Kyungsuk Jung, Pooja Ghatalia, Samuel Litwin, Eric M Horwitz, Robert G Uzzo, Richard E Greenberg, Rosalia Viterbo, Daniel M Geynisman, Alexander Kutikov, Elizabeth R Plimack, Marc C Smaldone, Yu-Ning Wong, Marijo Bilusic
INTRODUCTION: Small-cell carcinoma of the bladder is a poorly differentiated neoplasm with aggressive behavior. We analyzed clinical outcomes of patients who were treated at our institution to identify an optimal treatment strategy. MATERIALS AND METHODS: Retrospective chart analysis was performed for patients who were treated for small-cell carcinoma of the bladder at Fox Chase Cancer Center between 1995 and 2015. Survival was compared between different treatment periods (before January 2010 vs...
September 30, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/27930437/case-of-metastatic-urothelial-carcinoma-of-the-retina-and-vitreous
#8
Katherine E Whalen, Ralph C Eagle, Tamara R Vrabec
PURPOSE: To report a rare case of vitreo-retinal metastasis from urothelial carcinoma of the bladder. METHODS: Case report. RESULTS: A 55-year-old man with a history of bladder cancer developed atypical vitritis and a white fundus mass. Intravenous fluorescein angiography demonstrated connection between the retinal and tumor vasculature consistent with a retinal malignancy. Cytologic analysis of the vitreous sample revealed large, atypical cells with pleomorphic nuclei, mucin vacuoles, and rare mitotic figures...
December 7, 2016: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/27925039/metaplastic-squamous-cell-carcinoma-of-the-breast-a-case-report-and-literature-review
#9
Luciana Graziano, Paschoal Graziano, Almir Galvão Vieira Bitencourt, Daniel Bernal Soto, Alexandre Hiro, Cíntia Camillo Nunes
Metaplastic tumors are rare and represent a heterogeneous group of neoplasms showing dominant areas of non-glandular differentiation. Etiology and pathogenesis of this type of lesion in the breast is uncertain. The most common sources of metastatic squamous cell carcinoma of the breast are lung, esophagus, cervix, and urinary bladder. Squamous cell carcinomas may present clinically with inflammation and average size greater than breast adenocarcinoma. As for imaging studies, mammography shows no typical findings and ultrasound can show a complicated cyst or an inflammatory process, among the differential diagnoses...
October 2016: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/27916918/subchronic-toxicities-of-hz1006-a-hydroxamate-based-histone-deacetylase-inhibitor-in-beagle-dogs-and-sprague-dawley-rats
#10
Xiaofang Zhang, Xiaodong Zhang, Bojun Yuan, Lijun Ren, Tianbao Zhang, Guocai Lu
Histone deacetylase inhibitors (HDACIs), such as vorinostat and panobinostat, have been shown to have active effects on many hematologic malignancies, including multiple myeloma and cutaneous T-cell lymphoma. Hydroxamate-based (Hb) HDACIs have very good toxicity profiles and are currently being tested in phases I and II clinical trials with promising results in selected neoplasms, such as bladder carcinoma. One of the Hb-HDACIs, HZ1006, has been demonstrated to be a promising drug for clinical use. The aim of our study was to determine the possible target of toxicity and to identify a non-toxic dose of HZ1006 for clinical use...
November 30, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27894977/granular-cell-tumor-of-the-bladder-a-rare-neoplasm-managed-with-robotic-partial-cystectomy-using-near-infrared-filter-guidance
#11
Vidhush K Yarlagadda, Daniel G Benson, Jennifer B Gordetsky, Soroush Rais-Bahrami
No abstract text is available yet for this article.
November 25, 2016: Urology
https://www.readbyqxmd.com/read/27871870/carcinogenic-risk-of-emerging-persistent-organic-pollutant-perfluorooctane-sulfonate-pfos-a-proposal-of-classification
#12
Ricardo Arrieta-Cortes, Paulina Farias, Carlos Hoyo-Vadillo, Mina Kleiche-Dray
: Perfluoroalkyls are stable synthetic chemicals, able to repel oils, fats and water. These compounds have been used in the manufacturing of products such as Teflon(®), lubricants, paints, fire-fighting foams, coatings for pans, carpets, clothes, and paperboard for packaging, among others. It is believed that populations are exposed constantly to them. Its regulation in the world is under development and several controversies are in the course of litigation. One occupational study shows bladder cancer risk...
February 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/27864217/risk-of-second-malignant-neoplasms-in-women-and-girls-with-germ-cell-tumors
#13
Z Liao, M C Rodrigues, J N Poynter, J F Amatruda, C Rodriguez-Galindo, A L Frazier
BACKGROUND: While an elevated risk of second malignant neoplasms (SMNs) has been observed in men treated for germ cell tumors (GCTs), risk of SMNs have not been quantified in adult women or in girls treated for GCTs. PATIENTS AND METHODS: One-year survivors of primary GCTs diagnosed between January 1980 and December 2012 were identified from Surveillance, Epidemiology, and End Results (SEER 9) registries. Risk of SMNs was calculated using SEER*Stat. RESULTS: Among 1507 patients, a total of 47 SMNs were identified...
November 17, 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/27863160/primary-b-cell-lymphoma-of-the-uterine-cervix-presentation-in-pap-test-slide-and-cervical-biopsy
#14
Guang Yang, Jeremy Deisch, Margaret Tavares, Qin Haixia, Camilla Cobb, Anwar S Raza
This case involved a 69-year-old female who presented with irritative urinary voiding. Imaging studies showed an 18-cm uterine mass centering on the cervix and extending into the bladder. The Pap test slide demonstrated necrotic background and degenerative changes in single and grouped atypical "small round blue cells" with high nuclear/cytoplasm ratio, scant cytoplasm, and hyperchromatic focally cleaved nuclei with occasional nuclear membrane "snout projections." Cervical biopsies showed similar findings. The tumor cells were positive for CD45, CD20, and PAX-5, and negative with epithelial, neuroendocrine, and muscle markers...
November 8, 2016: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/27844130/-second-neoplasms-after-percutaneous-radiotherapy
#15
F Haidl, D Pfister, R Semrau, A Heidenreich
Radiation therapy represents an alternative treatment to radical prostatectomy in the management of clinically localized prostate cancer. Radiation-induced second neoplasms are defined by a latency period of at least 5 years, location within the field of radiation therapy, and a histology which differs from the primary tumor. Based on the data in the literature, there is a consistently increased risk of bladder cancer (HR: 1.67, 95% CI 1.55-1.80), rectal cancer (HR: 1.79, 95% CI 1.34-2.38), and colorectal cancer (HR: 1...
November 14, 2016: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/27843222/prolapsing-cystitis-cystica-causing-bladder-outlet-obstruction-an-unusual-complication
#16
Pankaj Halder, Kartik Chandra Mandal, Sumedha Mukherjee
Cystitis cystica (CC) is aproliferative disorder of bladder urothelium and usually subsides with medical therapy. However, this is not true for severe CC where surgical intervention is required to control breakthrough urinary tract infection (UTI). It may be mistaken as bladder neoplasm or posterior urethral valve, especially in children. Here, we report a case of CC in a 2-year-old boy where we had to excise the large pedunculated intravesical lesion to control breakthrough UTI and ongoing renal damage.
October 2016: Indian Journal of Urology: IJU: Journal of the Urological Society of India
https://www.readbyqxmd.com/read/27828906/a-case-of-metastatic-urothelial-carcinoma-of-the-retina-and-vitreous
#17
Katherine E Whalen, Ralph C Eagle, Tamara R Vrabec
PURPOSE: To report a rare case of vitreoretinal metastasis from urothelial carcinoma of the bladder. METHODS: Case report. RESULTS: A 55-year-old male with a history of bladder cancer developed atypical vitritis and a white fundus mass. IV fluorescein angiography demonstrated connection between the retinal and tumor vasculature consistent with a retinal malignancy. Cytologic analysis of the vitreous sample revealed large atypical cells with pleomorphic nuclei, mucin vacuoles, and rare mitotic figures...
November 8, 2016: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/27826047/elevated-preoperative-plasma-fibrinogen-level-is-an-independent-predictor-of-malignancy-and-advanced-stage-disease-in-patients-with-bladder-urothelial-tumors
#18
Jikai Liu, Dawei Li, Li Cao, Zhanyu Wang, Yan Li, Hainan Liu, Gang Chen
PURPOSE: To investigate the association between preoperative plasma fibrinogen levels and clinicopathological features in patients with bladder urothelial tumors. METHODS: In this retrospective single-center study, we evaluated preoperative plasma fibrinogen levels in 503 patients newly diagnosed with bladder urothelial tumors between January 2009 and October 2014. All patients received surgical intervention as the primary treatment method. Associations between preoperative plasma fibrinogen levels and clinicopathological parameters were analyzed...
December 2016: International Journal of Surgery
https://www.readbyqxmd.com/read/27803244/inflammatory-myofibroblastic-tumour-of-the-urinary-bladder-managed-with-partial-cystectomy-a-case-report-literature-review
#19
Nkwam Nkwam, Bethan Johnson, Alvaro Bazo, Tom A McCulloch, Gurminder S Mann
Inflammatory myofibroblastic tumour (IMT) is a rare neoplasm which can affect many different organs throughout the body. We report the case of a 62-year old female presenting with visible haematuria found to have IMT of the urinary bladder exhibiting anaplastic lymphoma kinase-1 gene rearrangement, initially managed with local resection and then definitively with partial cystectomy.
November 1, 2016: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/27792139/lack-of-tert-promoter-mutations-in-human-b-cell-non-hodgkin-lymphoma
#20
Gary Lam, Rena R Xian, Yingying Li, Kathleen H Burns, Karen L Beemon
Non-Hodgkin lymphomas (NHL) are a heterogeneous group of immune cell neoplasms that comprise molecularly distinct lymphoma subtypes. Recent work has identified high frequency promoter point mutations in the telomerase reverse transcriptase (TERT) gene of different cancer types, including melanoma, glioma, liver and bladder cancer. TERT promoter mutations appear to correlate with increased TERT expression and telomerase activity in these cancers. In contrast, breast, pancreatic, and prostate cancer rarely demonstrate mutations in this region of the gene...
October 25, 2016: Genes
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