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https://www.readbyqxmd.com/read/29453600/argininosuccinate-synthetase-1-ass1-loss-in-high-grade-neuroendocrine-carcinomas-of-the-urinary-bladder-implications-for-targeted-therapy-with-adi-peg-20
#1
Sounak Gupta, Divya Sahu, John S Bomalaski, Igor Frank, Stephen A Boorjian, Prabin Thapa, John C Cheville, Donna E Hansel
High-grade neuroendocrine carcinomas (HGNECs) of the urinary bladder encompass small cell (SCNEC) and large cell neuroendocrine carcinomas (LCNEC). Currently, recommended initial management is with systemic chemotherapy, followed by consolidative therapy with either radical cystectomy or radiotherapy in patients with localized disease. Nevertheless, survival in this setting remains poor. We therefore evaluated the potential to modify arginine metabolism as an alternative, targeted therapy approach in these carcinomas...
February 16, 2018: Endocrine Pathology
https://www.readbyqxmd.com/read/29445503/overview-of-occupational-cancer-in-painters-in-korea
#2
REVIEW
Jun-Pyo Myong, Younmo Cho, Min Choi, Hyoung-Ryoul Kim
Comprehensive consideration is necessary for setting guidelines to evaluate evidence of occupational cancer in painters due to work-related exposure to carcinogens in paint (a phenomenon termed herein as "work-relatedness"). The aim of the present research is to perform a comprehensive review and to suggest criteria for the provision of compensation for occupational neoplasm among painters in Korea. In order to perform a comprehensive review, this study assessed and evaluated scientific reports of carcinogenicities from the International Agency for Research on Cancer (IARC) and the Industrial Injuries Advisory Council (IIAC), as well as reviewed the existing literature about occupational exposure among painters in Korea and the epidemiologic investigations of claimed cases of cancer among painters in Korea...
2018: Annals of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29434839/the-link-between-foxj1-expression-level-in-bladder-carcinoma-and-tumor-recurrence
#3
Bing Liang, Xinwei He, Donghao Shang, Ye Tian, Zongwen Liu
We studied the expression level of FOXJ1 in bladder epithelial carcinoma and its relation to clinical features and tumor recurrence. From January 2014 to June 2015, 66 patients with bladder epithelial carcinoma were enrolled in this study and their tumor and para-carcinoma tissue samples were collected. FOXJ1 positive expression rate was evaluated using immunohistochemical staining, and FOXJ1 mRNA expression level was measured by RT-PCR. RT-PCR and immunohistochemistry results showed that FOXJ1 expression level in tumor samples was significantly lower than that in para-carcinoma tissue samples...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29434343/differential-expression-patterns-of-gata3-in-usual-and-differentiated-types-of-vulvar-intraepithelial-neoplasia-potential-diagnostic-implications
#4
Abha Goyal, Gloria Zhang, Bin Yang
The two main precursors of vulvar squamous cell carcinoma, usual and differentiated vulvar intraepithelial neoplasia (VIN), have distinctive etiology, pathogenesis, and natural history. Usual type VIN is often associated with high-risk HPV and differentiated VIN has de novo p53 genetic alterations that are unrelated to HPV infection. GATA-binding protein 3 (GATA3) is a tumor suppressor that shows increased expression in several types of human malignancies including breast and bladder carcinomas. Little is known regarding the expression of GATA3 in vulvar squamous neoplasms...
February 13, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29430511/disparities-in-the-use-of-continent-urinary-diversions-after-radical-cystectomy-for-bladder-cancer
#5
Nicholas J Farber, Izak Faiena, Viktor Dombrovskiy, Alexandra L Tabakin, Brian Shinder, Rutveej Patel, Sammy E Elsamra, Thomas L Jang, Eric A Singer, Robert E Weiss
Background: Radical cystectomy (RC) with ileal conduit (IC) or continent diversion (CD) is standard treatment for high-risk non-invasive and muscle-invasive bladder cancer. Objective: Our aim is to study contemporary trends in the utilization of ICs and CDs in patients undergoing RC. Methods: Using the National Inpatient Sample 2001-2012, we identified all patients diagnosed with a malignant bladder neoplasm who underwent RC followed by IC or CD...
January 20, 2018: Bladder Cancer
https://www.readbyqxmd.com/read/29406048/paraganglioma-of-the-urinary-bladder-a-rare-cause-of-hypertension-and-urinary-tract-infections
#6
Gerard Chaaya, Jorge Morales, Analia Castiglioni, Noman Subhani, Abdo Asmar
Pheochromocytoma is a neoplasm, which develops from cells of the chromaffin tissues that are derived from the ectodermic neural system and mostly situated within the adrenal medulla. Approximately 15% of pheochromocytoma cases arise from extra-adrenal chromaffin tissue. Pheochromocytoma of the bladder is rare and accounts for less than 0.06% of all bladder neoplasms and less than 1% of all pheochromocytomas. We report a case of a young woman who presented with uncontrolled hypertension, recurrent urinary tract infections and micturition attacks and was found to have a metastatic bladder paraganglioma...
February 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29395466/diagnostic-difficulties-in-cases-of-papillary-urothelial-neoplasm-of-low-malignant-potential-urothelial-proliferation-of-uncertain-malignant-potential-urothelial-dysplasia-and-urothelial-papilloma-a-review-of-current-literature
#7
REVIEW
Damian Jaworski, Łukasz Szylberg, Arkadiusz Gzil, Peter Stawinski, Anna Kasperska, Andrzej Marszałek
Tumours of the urinary tract are the fifth most frequent type of cancer. The most common types are urothelial tumours, among which, non-invasive urothelial neoplasms represent 45% of all cases. The 2016 WHO classification of urinary tract tumours introduced new classifications of non-invasive lesions. Besides urothelial papilloma (UP) and papillary urothelial neoplasm of low malignant potential (PUNLMP), as described in the former classification, the new classification also includes new entities such as urothelial proliferation of uncertain malignant potential (UPUMP) and urothelial dysplasia (UD)...
December 17, 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29394977/bladder-distension-as-a-cause-of-abdominal-compartment-syndrome
#8
Muhammad Yasir, Muhammad Qamarul Hoda, Tauseef Ahmed
Abdominal compartment syndrome (ACS) is increasingly identified in critically ill patient and its harmful effects are well documented. The disparity among the pressure, volume in abdominal cavity and its contents, results in ACS. The actual incidence of ACS is not known. However, it has been observed predominantly in patients with severe blunt and penetrating abdominal trauma, ruptured abdominal aortic aneurysms, retro- and intra-peritoneal hemorrhage, pneumoperitoneum, neoplasm, pancreatitis, ascites and multiple bone fracture...
February 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29394856/-a-case-of-malignant-transformation-of-intraductal-papillary-mucinous-neoplasm-of-the-pancreas-accompanied-by-metachronous-triple-primary-cancer
#9
Takashi Noma, Hajime Hirose, Yoshito Ide, Hiroki Imamura, Yuriko Yagi, Yukako Mokutani, Yasuji Hashimoto, Kenichi Nagai, Jin Matsuyama, Masaru Kubota, Yukio Fukushima, Shigeyuki Tamura, Yo Sasaki
A 70's woman with a history of abdominal surgery for gastric cancer visited our hospital for the evaluation of bleeding during defecation.We diagnosed her with advanced rectal cancer and performed laparoscopic low anterior resection.As postoperative pathological staging was pT3N2M0, pStage III b, we included CapeOx therapy as adjuvant chemotherapy.One year and 4 months after the surgery, lung and liver metastases were revealed by CT and PET-CT scans.At the same time, dilatation of the main pancreatic duct(intraductal papillary mucinous neoplasm: IPMN)was detected...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29390408/asymptomatic-solitary-bladder-plasmocytoma-a-case-report-and-literature-review
#10
Luigi Cormio, Vito Mancini, Beppe Calò, Oscar Selvaggio, Teobaldo Mazzilli, Francesca Sanguedolce, Giuseppe Carrieri
RATIONALE: Solitary extramedullary plasmocytoma may arise in any organ, either as a primary tumor or as part of a systemic myeloma; if it rarely affects bladder, it presents with urinary symptoms. We describe the first case of asymptomatic BP occasionally diagnosed in a patient with ascites. PATIENT CONCERNS: A 74-year-old woman with hepatitis C virus (HCV)-related liver cirrhosis presented with ascites and no urinary or other symptoms. DIAGNOSES: Routine blood tests were within normal ranges, except for mild elevation of transaminases due to chronic hepatitis...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29390388/bladder-cancer-detection-and-image-quality-compared-among-ishim-resolve-and-ss-epi-diffusion-weighted-mr-imaging-with-high-b-value-at-3-0-t-mri
#11
Hongyi Li, Lin Liu, Qinglei Shi, Alto Stemmer, Hong Zeng, Yi Li, Mengchao Zhang
To compare the detection of bladder neoplasms and image quality among the diffusion-weighted imaging (DWI) acquired by the prototype single-shot echo-planar-imaging (ss-EPI) sequence for integrated slice-specific dynamic shimming (iShim), readout segmentation of long variable echo trains (RESOLVE) and conventional ss-EPI sequences.Around 63 patients with 77 bladder lesions were enrolled. The MR protocol included T1WI, T2WI and 3 types of DWI. The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of each DWI for the detection of bladder tumor were computed...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29366854/grading-of-urothelial-carcinoma-and-the-new-world-health-organisation-classification-of-tumours-of-the-urinary-system-and-male-genital-organs-2016
#12
REVIEW
Eva M Compérat, Maximilian Burger, Paolo Gontero, A Hugh Mostafid, Joan Palou, Morgan Rouprêt, Bas W G van Rhijn, Shahrokh F Shariat, Richard J Sylvester, Richard Zigeuner, Marko Babjuk
CONTEXT: In the management of urothelial carcinoma, determination of the pathological grade aims at stratifying tumours into different prognostic groups to allow evaluation of treatment results, and optimise patient management. This article reviews the principles behind different grading systems for urothelial bladder carcinoma discussing their reproducibility and prognostic value. OBJECTIVE: This paper aims to show the evolution of the World Health Organisation (WHO) grading system, discussing their reproducibility and prognostic value, and evaluating which classification system best predicts disease recurrence and progression...
January 20, 2018: European Urology Focus
https://www.readbyqxmd.com/read/29342465/de-novo-bladder-urothelial-neoplasm-in-renal-transplant-recipients-a-retrospective-multicentered-study
#13
Anna Palazzetti, Andrea Bosio, Ettore Dalmasso, Paolo Destefanis, Fabrizio Fop, Francesca Pisano, Giuseppe Segoloni, Luigi Biancone, Alessandro Volpe, Antonia Di Domenico, Carlo Terrone, Samuele Iesari, Antonio Famulari, Paola Todeschini, Bruno Frea, Paolo Gontero
BACKGROUND AND OBJECTIVES: Renal transplant recipients (RTRs) have a 2- to 7-fold risk of developing a neoplasm compared to general population. Bladder urothelial neoplasms in this cohort has an incidence of 0.4-2%. Many reports describe a more aggressive behavior. The objective of this study is to describe oncologic characteristics of bladder urothelial neoplasms in RTRs and to evaluate its recurrence, progression, and survival rates. METHODS: A retrospective multicentered study was performed evaluating all de novo bladder urothelial neoplasms cases in RTRs from 1988 to 2014...
January 17, 2018: Urologia Internationalis
https://www.readbyqxmd.com/read/29336367/reduction-of-tat-interacting-protein-30-expression-could-be-a-prognostic-marker-in-bladder-urothelial-cancer
#14
Ye-Ping Li, Jian-Fang Zhu, Ka-Te Huang, Rong-Rong Wang, Bing Cai, Hui Xie, Hong-De Chen
BACKGROUND: Tat-interacting protein 30 (TIP30) has been reported to be a tumor suppressor, with reduced or absent expression in various tumors. However, its role in bladder urothelial cancer (BUC) has not been investigated. Therefore, herein, we investigated the expression of TIP30 protein in BUC and normal bladder mucosa and the clinical significance of TIP30 expression in the prognosis of BUC. METHODS: We reviewed data from 79 cases of BUC and 15 adjacent tissue samples from 79 patients treated at our institution between 2004 and 2007...
January 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29323063/evaluation-of-muc1-and-p53-expressions-in-noninvasive-papillary-urothelial-neoplasms-of-bladder-their-relationship-with-tumor-grade-and-role-in-the-differential-diagnosis
#15
Esin Kaymaz, Elif Ozer, Hatice Unverdi, Sema Hucumenoglu
PURPOSE: The aim of this study was to investigate the usability of MUC1 and p53 for differential diagnosis of noninvasive papillary urothelial neoplasias, especially for distinguishing papillary urothelial neoplasm of low malignant potential (PUNLMP) from low-grade papillary urothelial carcinoma (LGPUC) when the histologic signs are not obvious. MATERIALS AND METHODS: Seventeen biopsy specimens of the patients with PUNLMP, 20 with LGPUC and 13 with high-grade papillary urothelial carcinoma (HGPUC) were stained for MUC1 and p53 protein by immunohistochemical methods...
October 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29290317/histiocytic-sarcoma-with-bladder-involvement-case-report-and-literature-review
#16
Mª Jesús Fernández-Aceñero, Pablo Pérez Alonso, Cristina Díaz Del Arco
We report an unusual case of histiocytic sarcoma with bladder involvement. An 80 year-old man with a previous history of diffuse large B-cell malignant lymphoma presented with hematuria and back pain. Serial urine cytologies revealed no urothelial malignant cells, but cystoscopy showed a large intravesical mass. The patient underwent transurethral resection (TUR) of the tumor. The bladder TUR specimen showed a widely infiltrating epithelioid neoplasm, with intense immunohistochemical positivity for CD45 and histiocytic markers (CD68, lysozime and fascin)...
January 2018: Revista Española de Patología
https://www.readbyqxmd.com/read/29284232/chromium-in-urothelial-carcinoma-of-the-bladder
#17
Tomasz Golabek, Katarzyna Socha, Jacek Kudelski, Barbara Darewicz, Renata Markiewicz-Zukowska, Piotr Chlosta, Maria Borawska
INTRODUCTION AND OBJECTIVES: Many epidemiological and experimental studies report a strong role of chemical carcinogens in the etiology of bladder cancer. However, the involvement of heavy metals in tumourigenesis of urothelial carcinoma of the bladder has been poorly investigated. Therefore, the aim of this study was to examine the relationship between chromium (Cr) and bladder cancer. MATERIAL AND METHODS: Chromium concentration in two 36-sample series of bladder cancer tissue and sera from patients with this neoplasm were matched with those of a control group...
December 23, 2017: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/29279584/immunohistochemical-expression-of-nanog-in-urothelial-carcinoma-of-the-bladder
#18
M K A Md Akhir, H Hussin, A Veerakumarasivam, C S Choy, M A Abdullah, F Abd Ghani
Urothelial carcinoma is a common malignant neoplasm that has a poor prognosis and a high frequency of recurrence and metastasis. Constant disease surveillance with periodic and long term cystoscopy examination is necessary for management of the disease. However, the monitoring and therapy regimen is expensive, incurring a massive burden to patients and the government. Therefore, the development of specific biomarkers for urothelial carcinoma at an early stage and recurrence detection becomes a priority. Homeobox genes are a family of genes that are involved in tumourigenesis...
December 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/29236218/the-dangers-of-the-head-down-position-in-patients-with-untreated-pituitary-macroadenomas-case-series-and-review-of-literature
#19
Satoshi Kiyofuji, Avital Perry, Christopher S Graffeo, Caterina Giannini, Michael J Link
PURPOSE: Cavernous sinus syndrome is a rare phenomenon, characterized by simultaneous neuropathies of cranial nerves III-VI. Various pathological processes have been reported as precipitating etiologies, including infection, inflammation, vascular lesions, and neoplasms. PURPOSE: We report a unique case series of cavernous sinus syndrome attributable to prolonged Trendelenburg or prone positioning during non-cranial procedures and review the pertinent literature to enlighten on this rare but catastrophic phenomenon...
December 13, 2017: Pituitary
https://www.readbyqxmd.com/read/29221636/urothelial-neoplasms-in-pediatric-and-young-adult-patients-a-large-single-center-series
#20
James A Saltsman, Marcus M Malek, Victor E Reuter, William J Hammond, Enrico Danzer, Harry W Herr, Michael P LaQuaglia
PURPOSE: Bladder cancer is the sixth most common cancer in the United States, but is exceedingly rare in young patients, leading to a lack of accepted standards for diagnosis, treatment, and surveillance. We review our institutional experience with bladder urothelial neoplasms in pediatric and young adult patients summarizing presentation, treatment, and outcomes. METHODS: Surgical pathology records at our institution were searched for cases of urothelial neoplasms among patients ≤25 years of age treated between January 1997 and September 2016...
November 14, 2017: Journal of Pediatric Surgery
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