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R Schleip

R Schleip, J Wilke, S Schreiner, M Wetterslev, W Klingler
Quantification of myofibroblasts is a promising method for assessing tissue properties in the field of fascia research. This is commonly performed by immunohistochemistry for α-smooth muscle actin. However, usually larger tissue samples sizes are required for quantification. The aim of this investigation was to explore whether a microscopic quantification of myofibroblasts can be conducted with fascial tissue samples derived via percutaneous needle biopsy. Fascial tissues were derived via percutaneous needle biopsy from the fascia lata of 11 persons (aged 19-40 years)...
April 2018: Clinical Anatomy
R Schleip, W Klingler, S Wearing, I Naylor, M Zuegel, K Hoppe
INTRODUCTION: While two laboratory techniques are commonly used to assess the tensile properties of muscle tissue, emerging evidence suggests that the fascial components of these tissues also serve an active role in force generation. Hence, we investigated whether these techniques are sensitive for assessment of fascial micromechanics. METHODS: Force measurements on dissected fascial tissue were performed either using the classical immersion organ bath or using an improved superfusion approach simulating pulsed pharmacological triggers...
September 7, 2016: Journal of Musculoskeletal & Neuronal Interactions
W Klingler, M Velders, K Hoppe, M Pedro, R Schleip
Fascia is composed of collagenous connective tissue surrounding and interpenetrating skeletal muscle, joints, organs, nerves, and vascular beds. Fascial tissue forms a whole-body, continuous three-dimensional viscoelastic matrix of structural support. The classical concept of its mere passive role in force transmission has recently been disproven. Fascial tissue contains contractile elements enabling a modulating role in force generation and also mechanosensory fine-tuning. This hypothesis is supported by in vitro studies demonstrating an autonomous contraction of human lumbar fascia and a pharmacological induction of temporary contraction in rat fascial tissue...
2014: Current Pain and Headache Reports
K Hoppe, R Schleip, F Lehmann-Horn, H Jäger, W Klingler
Malignant hyperthermia is a dreaded complication of general anaesthesia. Predisposed individuals can be identified using the standardised caffeine/halothane in-vitro contracture test on a surgically dissected skeletal muscle specimen. Skeletal muscle is composed of muscle fibres and interwoven fascial components. Several malignant hyperthermia-associated neuromuscular diseases are associated with an altered connective tissue composition. We analysed adjacent fascial components of skeletal muscle histologically and physiologically...
September 2014: Anaesthesia
F H Willard, A Vleeming, M D Schuenke, L Danneels, R Schleip
In this overview, new and existent material on the organization and composition of the thoracolumbar fascia (TLF) will be evaluated in respect to its anatomy, innervation biomechanics and clinical relevance. The integration of the passive connective tissues of the TLF and active muscular structures surrounding this structure are discussed, and the relevance of their mutual interactions in relation to low back and pelvic pain reviewed. The TLF is a girdling structure consisting of several aponeurotic and fascial layers that separates the paraspinal muscles from the muscles of the posterior abdominal wall...
December 2012: Journal of Anatomy
Arya Nielsen
This article is based on research findings published by Nielsen et al. [2007a. The effect of 'Gua sha' treatment on the microcirculation of surface tissue: a pilot study in healthy subjects. EXPLORE: The Journal of Science and Healing 3, 456-466]. The abstract was accepted for poster session at the conference on fascia ( and appears in the conference text Fascia Research [Nielsen, A., Knoblauch, N., Dobos, G., Michalsen, A., Kaptchuk, T., 2007b. The effect of 'Gua sha' treatment on the microcirculation of surface tissue: a pilot study in healthy subjects...
January 2009: Journal of Bodywork and Movement Therapies
R Schleip, W Klingler, F Lehmann-Horn
Dense connective tissue sheets, commonly known as fascia, play an important role as force transmitters in human posture and movement regulation. Fascia is usually seen as having a passive role, transmitting mechanical tension which is generated by muscle activity or external forces. However, there is some evidence to suggest that fascia may be able to actively contract in a smooth muscle-like manner and consequently influence musculoskeletal dynamics. General support for this hypothesis came with the discovery of contractile cells in fascia, from theoretical reflections on the biological advantages of such a capacity, and from the existence of pathological fascial contractures...
2005: Medical Hypotheses
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