Yuting Yang, Chunbin Xu, Shengqian Xu, Yan Li, Ke'er Chen, Tao Yang, Jiaqi Bao, Yajing Xu, Jingyao Chen, Chuanbin Mao, Lili Chen, Weilian Sun
Developing biomaterials capable of promoting bone regeneration in bacteria-infected sites is of utmost urgency for periodontal disease therapies. Here we produce a hybrid hydrogel by integrating CuS nanoparticles (CuSNPs), which could kill bacteria through photothermal therapy (PTT) triggered by a near infrared (NIR) light, and a gelatin methacryloyl (GelMA) hydrogel, which is injectable and biocompatible. Specifically, CuSNPs were precipitated by chitosan (CS) firstly, then grafted with methacrylic anhydride (MA) to form CuSNP@CS-MA, which was photo-crosslinked with GelMA to synthesize hybrid hydrogels (GelMA/CuSNP)...
May 7, 2024: Biomaterials Science