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Subrachnoid hemorrhage

Jian-Ru Li, Hang-Zhe Xu, Sheng Nie, Yu-Cong Peng, Lin-Feng Fan, Zhi-Jiang Wang, Cheng Wu, Feng Yan, Jing-Yin Chen, Chi Gu, Chun Wang, Jing-Sen Chen, Lin Wang, Gao Chen
BACKGROUND: The NLRP3 inflammasome is a multiprotein complex that regulates the innate immune inflammatory response by activating caspase-1 and subsequent IL-1β and IL-18. Fluoxetine has been shown to have the anti-inflammatory properties in many disease models. However, the effects and mechanisms of these effects of fluoxetine in early brain injury after subarachnoid hemorrhage (SAH) have not been defined. METHODS: The SAH model was induced by an endovascular perforation in adult male Sprague-Dawley (SD) rats weighing 300-320 g...
September 13, 2017: Journal of Neuroinflammation
Biagio Solarino, William Ralston, Kevin Younger, Donna M Hunsaker
In this article, we report an unusual case of sudden death arising from a ruptured basilar artery aneurysm during a suicide attempt. A 72-year-old male was found dead in his home after sustaining superficial flesh gunshot wounds (entrace and exit) involving the forehead. The victim had been depressed for several months and had frank suicide intention. The pertinent autopsy findings revealed a superficial nonpenetrating bullet path of the scalp with no skull fractures or brain injuries. However, brain examination identified subrachnoid hemorrhage and subdural clot about the brainstem and within the posterior fossa, linked to a basilar artery aneourysm rupture...
September 2006: Forensic Science, Medicine, and Pathology
Michael Chen
BACKGROUND: Ruptured and thrombosed cerebral aneurysms pose a risk for rebleeding that may go undetected because they are angiographically occult. The presence of multiple aneurysms may further complicate efforts in accurately identifying the true source because their treatment may circumvent further necessary investigations. METHODS: This case series and literature review illustrates the background and clinical features of ruptured thrombosed cerebral aneurysms...
December 2014: Journal of Neurointerventional Surgery
Sebastian Thomas, Birte Herrmann, Madjid Samii, Thomas Brinker
BACKGROUND: Traumatic subarachnoid hemorrhage is a common finding following traumatic brain injury. Clinical studies revealed a positive influence of Nimodipine. However, till now no experimental studies have been performed. The aim of the present study was to determine the influence of early Nimodipine administration on outcome and histological findings in the rat: METHODS: Diffuse brain injury was produced in Sprague-Dawley rats using a brass weight falling from a predetermined height...
2008: Acta Neurochirurgica. Supplement
H Tapia-Perez, M Sanchez-Aguilar, J Torres-Corzo, I Rodriguez-Leyva, L B Herrera-Gonzalez
INTRODUCTION: The 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA) inhibitors or statins are drugs used in the treatment of dyslipidemies. The clinical trials performed for evaluation of the efficacy observed a reduced incidence of stroke and other trials have demonstrated a better outcome after stroke and subrachnoid hemorrhage. DEVELOPMENT: In the last years, new actions of statins have been described (pleiotropics). The statins seem to originate neuroprotector effects, such as up-regulation of endothelial nitric oxide synthase; creation of a fibrinolytic profile with suppression of the intravascular stability of the clot; immunomodulation by regulation of cytokines and cellular adhesion molecules; anti-oxidation by reduction of lipidic peroxidation; induction of neuroplasticity by increment of neurotrophic factors and protection of neuroexcitotoxicity, maybe by regulation of intracellular calcium or depletion of intracellular sterols...
September 16, 2007: Revista de Neurologia
G A Brazenor, M J Chamberlain, A W Gelb
Two patients who had suffered subrachnoid hemorrhage were subjected to intensive monitoring of parameters of circulating blood flow, cardiovascular dynamics, and fluid and electrolyte balance. Among the parameters studied were red cell volume, plasma volume, and total blood volume, cardiac output, and central venous and pulmonary capillary wedge pressures. Both patients experienced acute neurological deterioration during the study. Red cell volume fell in a premonitory fashion prior to neurological deterioration in both, and in one patient plasma volume and total blood volume decreased by almost 50% in the 5 days prior to neurological deterioration...
March 1990: Journal of Neurosurgical Anesthesiology
K Ogane, S Fujita, H Ohkuma, S Suzuki
We report a case of delayed subarachnoid hemorrhage (SAH) from a vertebrobasilar artery dissecting aneurysm (VBA-DA). The patient was a healthy 32-year-old woman with a sudden onset of severe occipitalgia. Next day, her headache improved gradually, and she consulted with our department. Although we initially suspected that she was suffering from SAH, neurological findings, CT, and cerebrospinal fluid examination did not reveal any abnormal conditions, including SAH. Therefore, she was treated conservatively with analgesics...
September 2000: Nō to Shinkei, Brain and Nerve
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