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https://www.readbyqxmd.com/read/28526665/the-sensor-study-protocol-for-a-mixed-methods-study-of-self-management-checks-to-predict-exacerbations-of-pseudomonas-aeruginosa-in-patients-with-long-term-respiratory-conditions
#1
Claire Roberts, Thomas L Jones, Samal Gunatilake, Will Storrar, Scott Elliott, Sharon Glaysher, Ben Green, Steven Rule, Carole Fogg, Ann Dewey, Kevin A Auton, Anoop J Chauhan
BACKGROUND: There are an estimated three million people in the United Kingdom with chronic obstructive pulmonary disease (COPD), and the incidence of bronchiectasis is estimated at around 0.1% but is more common in COPD and severe asthma. Both COPD and bronchiectasis are characterized by exacerbations in which bacteria play a central role. Pseudomonas aeruginosa is isolated from sputum samples from 4% to 15% of adults with COPD and is more likely to be isolated from patients with severe disease...
May 19, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28526419/a-brief-history-of-the-discovery-of-tick-borne-encephalitis-virus-in-the-late-1930s-based-on-reminiscences-of-members-of-the-expeditions-their-colleagues-and-relatives
#2
REVIEW
Vladimir I Zlobin, Vanda V Pogodina, Olaf Kahl
Tick-borne encephalitis virus is the etiological agent of a severe human disease transmitted by hard ticks. It occurs in large parts of eastern, central, and western Asia and in Europe with thousands of human cases each year. Here, the discovery of the virus by Soviet scientists in the late 1930s in the Far East is described. The pioneering work involved with this discovery, which resulted in great scientific and epidemiological achievement, was undertaken under the most difficult conditions, and some of the scientists and their technical assistants paid for it with their health and even their lives...
May 5, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/28521084/design-of-modular-protein-tags-for-the-orthogonal-covalent-bond-formation-at-specific-dna-sequences
#3
Thang Minh Nguyen, Eiji Nakata, Masayuki Saimura, Huyen Dinh, Takashi Morii
Simultaneous formation of specific covalent linkages at nucleotides in given DNA sequences demand distinct orthogonal reactivity of DNA modification agents. Such highly specific reactions require well-balanced reactivity and affinity of the DNA modification agents. Conjugation of a sequence-specific DNA binding zinc finger protein and a self-ligating protein-tag provides a modular adaptor that expedites formation of a covalent bond between the protein-tag and a substrate-modified nucleotide at a specific DNA sequence...
May 18, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28516834/comparison-of-antemortem-and-environmental-samples-for-zebrafish-health-monitoring-and-quarantine
#4
Marcus J Crim, Christian Lawrence, Robert S Livingston, Andrei Rakitin, Shane J Hurley, Lela K Riley
Molecular diagnostic assays offer both exquisite sensitivity and the ability to test a wide variety of sample types. Varioustypes of environmental sample, such as detritus and concentrated water, might provide a useful adjunct to sentinels in routinezebrafish health monitoring. Similarly, antemortem sampling would be advantageous for expediting zebrafish quarantine,without euthanasia of valuable fish. We evaluated the detection of Mycobacterium chelonae, M. fortuitum, M. peregrinum,Pseudocapillaria tomentosa, and Pseudoloma neurophilia in zebrafish, detritus, pooled feces, and filter membranes after filtration of 1000-, 500-, and 150-mL water samples by real-time PCR analysis...
May 17, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28515200/impact-of-expedited-partner-therapy-ept-implementation-on-chlamydia-incidence-in-the-usa
#5
Okeoma Mmeje, Sarah Wallett, Giselle Kolenic, Jason Bell
OBJECTIVES: The diagnosis and treatment of Chlamydia trachomatis infection is important in preventing persistent or recurrent infection. Expedited partner therapy (EPT) is the favoured and supported method for STI treatment of the Centers for Disease Control and Prevention when the provider cannot be assured that all recent sexual partner(s) will seek therapy. EPT is legally permissible in 38 states and is endorsed by healthcare organisations to decrease the rates of chlamydia and gonorrhoea infection...
May 17, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28514458/effect-of-expedited-microneedle-assisted-photodynamic-therapy-for-field-treatment-of-actinic-keratoses-a-randomized-clinical-trial
#6
Tatyana A Petukhova, Lauren A Hassoun, Negar Foolad, Mayanka Barath, Raja K Sivamani
Importance: Photodynamic therapy (PDT) is an effective and cosmetically favorable treatment modality for actinic keratoses (AKs). However, prolonged incubation times and pain associated with treatment are burdensome to the patient and a hindrance to widespread use of PDT as standard field therapy for AK. Objective: To evaluate efficacy and pain associated with microneedle expedited PDT. Design, Setting, and Participants: The Microneedle Photodynamic Therapy II (MNPDT-II) study was a randomized, single-blinded, split-face controlled, 2-arm clinical trial...
May 17, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28514047/a-simplified-approach-for-fabrication-of-a-lightweight-individualized-impression-tray-with-the-aid-of-existing-obturator-prosthesis-using-lost-salt-technique
#7
Amar Bhochhibhoya, Binod Acharya, Samskar Bickram Rana, Rinu Sharma, Brijesh Maskey
Maxillary defects resulting from ablative oncologic surgery can be extensive and usually have complex contours. Impression procedures for such defects can be time consuming and cumbersome, challenging the skills of even the most-experienced clinician. A well-oriented impression tray with proper extension and adequate contour is essential for successfully capturing the relevant details in impression. This article describes a method using the patient's existing obturator prosthesis to simplify and expedite the fabrication of a lightweight individualized impression tray directly on an irreversible hydrocolloid impression, thus avoiding the preliminary impression procedure for the patient...
May 17, 2017: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/28512170/deconstruction-of-interhospital-transfer-workflow-in-large-vessel-occlusion-real-world-data-in-the-thrombectomy-era
#8
Felix C Ng, Essie Low, Emily Andrew, Karen Smith, Bruce C V Campbell, Peter J Hand, Douglas E Crompton, Tissa Wijeratne, Helen M Dewey, Philip M Choi
BACKGROUND AND PURPOSE: Interhospital transfer is a critical component in the treatment of acute anterior circulation large vessel occlusive stroke transferred for mechanical thrombectomy. Real-world data for benchmarking and theoretical modeling are limited. We sought to characterize transfer workflow from primary stroke center (PSC) to comprehensive stroke center after the publication of positive thrombectomy trials. METHODS: Consecutive patients transferred from 3 high-volume PSCs to a single comprehensive stroke center between January 2015 and August 2016 were included in a retrospective study...
May 16, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28508066/australian-shelf-sediments-reveal-shifts-in-miocene-southern-hemisphere-westerlies
#9
Jeroen Groeneveld, Jorijntje Henderiks, Willem Renema, Cecilia M McHugh, David De Vleeschouwer, Beth A Christensen, Craig S Fulthorpe, Lars Reuning, Stephen J Gallagher, Kara Bogus, Gerald Auer, Takeshige Ishiwa
Global climate underwent a major reorganization when the Antarctic ice sheet expanded ~14 million years ago (Ma) (1). This event affected global atmospheric circulation, including the strength and position of the westerlies and the Intertropical Convergence Zone (ITCZ), and, therefore, precipitation patterns (2-5). We present new shallow-marine sediment records from the continental shelf of Australia (International Ocean Discovery Program Sites U1459 and U1464) providing the first empirical evidence linking high-latitude cooling around Antarctica to climate change in the (sub)tropics during the Miocene...
May 2017: Science Advances
https://www.readbyqxmd.com/read/28506696/current-approaches-for-avoiding-the-limitations-of-circulating-tumor-cells-detection-methods-implications-for-diagnosis-and-treatment-of-patients-with-solid-tumors
#10
REVIEW
Artur Kowalik, Magdalena Kowalewska, Stanisław Góźdź
Eight million people die of cancer each year and 90% of deaths are caused by systemic disease. Circulating tumor cells (CTCs) contribute to the formation of metastases and thus are the subject of extensive research and an abiding interest to biotechnology and pharmaceutical companies. Recent technological advances have resulted in greatly improved CTC detection, enumeration, expansion, and culture methods. However, despite the fact that nearly 150 years have passed since the first detection and description of CTCs in human blood and enormous technological progress that has taken place in this field, especially within the last decade, few CTC detection methods have been approved for routine clinical use...
April 26, 2017: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/28505701/-compatibility-of-work-and-family-life-survey-of-physicians-in-the-munich-metropolitan-area
#11
Meike Lauchart, Philipp Ascher, Karin Kesel, Sabine Weber, Beatrice Grabein, Bertram Schneeweiss, Cordula Fischer-Truestedt, Michael Schoenberg, Gudrun Rogler, Claudia Borelli
Aim Investigation of the compatibility of work and family life for physicians in the Munich metropolitan area. Methods Survey of a representative sample of 1,800 physicians using a questionnaire. Results Men were less satisfied (7% very satisfied vs. 21%) with compatibility between work and family life than women. The group least satisfied overall was hospital-based physicians (p=0.000, chi-square=122.75). Women rather than men cut back their career due to children, perceived their professional advancement as impaired, desisted from establishing private practice or quit hospital employment altogether...
May 15, 2017: Das Gesundheitswesen
https://www.readbyqxmd.com/read/28504356/bronchoscopy-in-children-with-tetralogy-of-fallot-pulmonary-atresia-and-major-aortopulmonary-collaterals
#12
Douglas R Sidell, Andrew M Koth, Holly Bauser-Heaton, Doff B McElhinney, Lisa Wise-Faberowski, Michael C Tracy, Frank L Hanley, Ritu Asija
OBJECTIVE: Children with Tetralogy of Fallot, Pulmonary Atresia, and Major Aortopulmonary Collaterals (TOF/PA/MAPCAs) undergoing unifocalization surgery are at risk for developing more postoperative respiratory complications than children undergoing other types of congenital heart surgery. Bronchoscopy is used in the perioperative period for diagnostic and therapeutic purposes. In this study, we describe bronchoscopic findings and identify factors associated with selection for bronchoscopy...
May 15, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/28504314/next-step-in-antibiotic-stewardship-pharmacist-provided-penicillin-allergy-testing
#13
Z Gugkaeva, J S Crago, M Yasnogorodsky
WHAT IS KNOWN: Penicillin allergy limits therapeutic options for patients but often disappears over time, leaving patients erroneously labelled allergic and leading to the utilization of broad-spectrum and more expensive antibiotics. Penicillin allergy can be effectively assessed via skin testing. OBJECTIVE: To improve patient access to penicillin allergy testing by implementing a pharmacist-provided service in a hospital setting. COMMENT: Beta-lactams remain a mainstream therapy for many infections due to their effectiveness, low side effects and affordability...
May 14, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28504240/maldi-tof-ms-in-the-microbiology-laboratory-current-trends
#14
Sören Schubert, Markus Kostrzewa
Within less than a decade matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) has become a gold standard for microbial identification in clinical microbiology laboratories. Besides identification of microorganisms the typing of single strains as well as the antibiotic and antimycotic resistance testing has come into focus in order to speed up the microbiological diagnostic. However, the full potential of MALDI-TOF MS has not been tapped yet and future technological advancements will certainly expedite this method towards novel applications and enhancement of current practice...
May 15, 2017: Current Issues in Molecular Biology
https://www.readbyqxmd.com/read/28503752/point-of-care-diagnosis-of-cardiac-tamponade-identified-by-the-flow-velocity-paradoxus
#15
William Shyy, Roneesha S Knight, Aaron Kornblith, Nathan A Teismann
The presentation of cardiac tamponade is a spectrum from occult to extreme. The clinical history, physical exam, electrocardiogram, and radiographic findings of tamponade have poor sensitivities and even worse specificities. We use a clinical scenario to demonstrate how point-of-care cardiac ultrasound can diagnose impending cardiac tamponade in a clinically stable patient. The ultrasound finding we recommend is the flow velocity paradoxus, in which respiratory variation causes significant changes in transvalvular inflow velocities, which are exaggerated when tamponade is present...
May 15, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28502674/evidence-based-drug-treatment-for-special-patient-populations-through-model-based-approaches
#16
REVIEW
Elke H J Krekels, J G Coen van Hasselt, John N van den Anker, Karel Allegaert, Dick Tibboel, Catherijne A J Knibbe
The majority of marketed drugs remain understudied in some patient populations such as pregnant women, paediatrics, the obese, the critically-ill, and the elderly. As a consequence, currently used dosing regimens may not assure optimal efficacy or minimal toxicity in these patients. Given the vulnerability of some subpopulations and the challenges and costs of performing clinical studies in these populations, cutting-edge approaches are needed to effectively develop evidence-based and individualized drug dosing regimens...
May 11, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28501750/development-validation-and-application-of-a-novel-liquid-chromatography-tandem-mass-spectrometry-assay-measuring-uracil-5-6-dihydrouracil-5-fluorouracil-5-6-dihydro-5-fluorouracil-%C3%AE-fluoro-%C3%AE-ureidopropionic-acid-and-%C3%AE-fluoro-%C3%AE-alanine-in-human-plasma
#17
Ottiniel Chavani, Berit Packert Jensen, R Matthew Strother, Christopher M Florkowski, Peter M George
The plasma 5,6-dihydrouracil/uracil (UH2/U) ratio is a possible phenotypic marker of dihydropyrimidine dehydrogenase (DPD) activity, hence an index of 5-fluorouracil (5-FU) response and toxicity. Studies have re-affirmed the value of 5-FU and 5,6-dihydro-5-fluorouracil (FUH2) for therapeutic drug monitoring (TDM). However, FUH2 has limited stability in plasma, necessitating expedited plasma separation and freezing, where routine compliance may not be easy. The metabolites α-fluoro-β-ureidopropionic acid (FUPA) and α-fluoro-β-alanine (FβAL) are stable in plasma and are probable candidates for TDM...
May 6, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28501500/it-s-about-time-the-development-and-validation-of-a-rapid-optimized-single-antigen-bead-rob-assay-protocol-for-labscreen
#18
Robert S Liwski, Anna L Greenshields, Cathi Murphey, Robert A Bray, Howard M Gebel
The LABScreen single antigen bead assay (SAB) is a method widely used for the identification and monitoring of human leukocyte antigen (HLA) antibodies in patients pre-and post-transplant. While accurate testing of patient samples is key for optimal patient care, time can also be important, especially during deceased donor workups or post-transplant assessments. Here we describe the development and validation of the Rapid Optimized SAB (ROB) protocol, a modified version of the One Lambda LABScreen SAB (OLSAB) procedure, which reduces assay time from 85 to 25 min (>70% reduction) without impacting assay quality or sensitivity...
May 10, 2017: Human Immunology
https://www.readbyqxmd.com/read/28500629/early-prediction-tool-to-identify-the-need-for-pharmacotherapy-in-infants-at-risk-of-neonatal-abstinence-syndrome
#19
Barbara T Isemann, Elaina C Stoeckle, Afshin A Taleghani, Eric W Mueller
OBJECTIVE: To develop a tool to predict the need for pharmacologic treatment of neonatal abstinence syndrome (NAS) within 36 hours from birth in infants at risk for opioid withdrawal. STUDY DESIGN: Retrospective study of infants born at 34 weeks or later gestation with in utero exposure to opioids during two time periods from January 2013 through October 2016. Period 1 was used to develop a predictive tool for validation during Period 2. Birth weight, gestational age, four categories of opioid exposure, and individual scores for 21 withdrawal symptoms from the Modified Finnegan Score at 36 hours of life were recorded...
May 13, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/28497848/isolation-of-subtelomeric-sequences-of-porcine-chromosomes-for-translocation-screening-reveals-errors-in-the-pig-genome-assembly
#20
R E O'Connor, G Fonseka, R Frodsham, A L Archibald, M Lawrie, G A Walling, D K Griffin
Balanced chromosomal aberrations have been shown to affect fertility in most species studied, often leading to hypoprolificacy (reduced litter size) in domestic animals such as pigs. With an increasing emphasis in modern food production on the use of a small population of high quality males for artificial insemination, the potential economic and environmental costs of hypoprolific boars, bulls, rams etc. are considerable. There is therefore a need for novel tools to facilitate rapid, cost-effective chromosome translocation screening...
May 12, 2017: Animal Genetics
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