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https://www.readbyqxmd.com/read/28727052/rapid-communication-subclinical-bovine-respiratory-disease-loci-and-pathogens-associated-with-lung-lesions-in-feedlot-cattle
#1
J N Kiser, T E Lawrence, M Neupane, C M Seabury, J F Taylor, J E Womack, H L Neibergs
Bovine respiratory disease (BRD) is an economically important disease of feedlot cattle that is caused by viral and bacterial pathogen members of the BRD complex. Many cases of subclinical BRD go untreated and are not detected until slaughter, when lung lesions are identified. The objectives of this study were to identify which BRD pathogens were associated with the presence of lung lesions at harvest and to identify genomic loci that were associated with susceptibility to lung lesions as defined by consolidation of the lung and/or the presence of fibrin tissue...
June 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28727016/genomewide-association-mapping-and-pathway-analysis-of-meat-tenderness-in-polled-nellore-cattle
#2
L M Castro, G J M Rosa, F B Lopes, L C A Regitano, A J M Rosa, C U Magnabosco
Brazil is one of the world's largest beef exporters, although the product has a low price due to quality issues. The meat exported by Brazil is considered medium and low quality by international buyers, mainly due to lack of tenderness. The predominant Zebu breeds (80% Nellore) are known for producing tougher beef than taurine breeds. Nonetheless, some studies have shown that there is substantial genetic variability for tenderness within the Nellore breed, although it is a difficult trait to improve by conventional selection methods...
May 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28726823/history-tracking-down-a-doomed-arctic-expedition
#3
Daniel Cressey
No abstract text is available yet for this article.
July 19, 2017: Nature
https://www.readbyqxmd.com/read/28726508/optimizing-mri-logistics-prospective-analysis-of-performance-efficiency-and-patient-throughput
#4
Kevin Beker, Alejandro Garces-Descovich, Jason Mangosing, Ines Cabral-Goncalves, Donna Hallett, Koenraad J Mortele
OBJECTIVE: The objective of this study is to optimize MRI logistics through evaluation of MRI workflow and analysis of performance, efficiency, and patient throughput in a tertiary care academic center. SUBJECTS AND METHODS: For 2 weeks, workflow data from two outpatient MRI scanners were prospectively collected and stratified by value added to the process (i.e., value-added time, business value-added time, or non-value-added time). Two separate time cycles were measured: the actual MRI process cycle as well as the complete length of patient stay in the department...
July 20, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28725147/shortage-of-psychotropic-medications-in-community-pharmacies-in-saudi-arabia-causes-and-solutions
#5
Yazed Sulaiman Al-Ruthia, Wael Mansy, Mohammad Barasin, Yazeed Mohammad Ghawaa, Mohammed AlSultan, Mohammad A Alsenaidy, Solaiman Alhawas, Sultan AlGhadeer
Background: Patients with mental disorders, such as depression and anxiety, who seek medical care in private psychiatric clinics in Riyadh, Saudi Arabia, have recently expressed concerns to doctors about difficulty in filling psychotropic medications, such as Amitriptyline and Aripiprazole, at retail community pharmacies. Objectives: The aim of this study was to investigate whether there is a shortage of some commonly prescribed psychotropic medications in retail community pharmacies in Saudi Arabia, and if so, to explore the possible reasons behind the shortage of these medications...
July 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/28724491/comparison-of-antemortem-and-environmental-samples-for-zebrafish-health-monitoring-and-quarantine
#6
Marcus J Crim, Christian Lawrence, Robert S Livingston, Andrei Rakitin, Shane J Hurley, Lela K Riley
Molecular diagnostic assays offer both exquisite sensitivity and the ability to test a wide variety of sample types. Various types of environmental sample, such as detritus and concentrated water, might provide a useful adjunct to sentinels in routine zebrafish health monitoring. Similarly, antemortem sampling would be advantageous for expediting zebrafish quarantine, without euthanasia of valuable fish. We evaluated the detection of Mycobacterium chelonae, M. fortuitum, M. peregrinum, Pseudocapillaria tomentosa, and Pseudoloma neurophilia in zebrafish, detritus, pooled feces, and filter membranes after filtration of 1000-, 500-, and 150-mL water samples by real-time PCR analysis...
July 1, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28723586/a-code-icu-expedited-review-of-critically-ill-patients-is-associated-with-reduced-emergency-department-length-of-stay-and-duration-of-mechanical-ventilation
#7
Matthew L Durie, Jai N Darvall, Daniel A Hadley, Mark A Tacey
PURPOSE: To examine the effect of a system of expedited review of critically ill patients in the Emergency Department (ED) on ED length of stay (LOS) and Intensive Care Unit (ICU) outcomes. MATERIALS AND METHODS: Retrospective cohort study at a tertiary hospital comparing two 12-month periods before and after implementation of a 'Code ICU' system of expedited review of critically ill patients in the ED. All adult ED to ICU admissions were included. Separate analyses were performed for patients intubated prior to ICU admission...
July 6, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28722762/rapid-depuration-of-mercury-in-songbirds-accelerated-by-feather-molt
#8
Margaret Whitney, Daniel Cristol
Mercury (Hg) is a ubiquitous environmental contaminant that affects avian reproduction and condition, in both aquatic and terrestrial species. Because Hg binds strongly to the keratin of growing feathers, molt is an important avenue for Hg elimination. We investigated the rate of depuration of Hg from songbird blood and organs (brain, kidney, liver, muscle) as a function of molt. We exposed 2 species of captive songbirds, European starling (Sturnus vulgaris) and zebra finch (Taeniopygia guttata), to environmentally relevant dietary Hg (1...
July 19, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28721701/challenges-of-connectedness-in-personal-recovery-for-rural-mothers-with-mental-illness
#9
Rochelle Helena Hine, Darryl Maybery, Melinda Jane Goodyear
Social connection is a fundamental human need, but challenging for individuals with characteristics that are socially stigmatized. Parenting with mental illness presents obstacles, as well as opportunities, for connection. In the present study, we examined connectedness within a personal recovery paradigm for rural mothers with a mental illness. In-depth interviews with 17 mothers with a mental illness, utilizing constructivist grounded theory, resulted in six categories of meaning, including 'yearning for connection', 'connecting intensely', 'encountering rejection and exclusion', 'choosing isolation', 'being known', and 'finding peers/helping others'...
July 18, 2017: International Journal of Mental Health Nursing
https://www.readbyqxmd.com/read/28720637/intersection-syndrome-the-subtle-squeak-of-an-overused-wrist
#10
Thomas M Skinner
Patient histories that include wrist pain can be pivotal in the distinction between intersection syndrome (IS) and the more common de Quervain's tenosynovitis (DQT). Presented here is a 26-year-old pregnant woman with a history of rowing who developed left radial/dorsal wrist pain and a rubbing/squeaking sensation. Nine months of conservative DQT therapy and a landmark-guided corticosteroid injection failed to relieve her symptoms. An in-clinic ultrasound showed tenosynovitis at the intersection of the first and second compartments, confirming a diagnosis of IS...
July 2017: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/28720080/long-term-effectiveness-of-mailed-nicotine-replacement-therapy-study-protocol-of-a-randomized-controlled-trial-5-year-follow-up
#11
Vladyslav Kushnir, Peter Selby, Laurie Zawertailo, Rachel F Tyndale, Scott T Leatherdale, John A Cunningham
BACKGROUND: Our group recently completed a randomized controlled trial, evaluating the efficacy of providing 5 weeks of free nicotine replacement therapy (NRT; in the form of the nicotine patch) by expedited postal mail without behavioral assistance to regular adult smokers interested in receiving it. The findings revealed that mailed provision of nicotine patches resulted in more than a doubling of quit rates at a six-month follow-up compared to a no intervention control group. While this trial provided evidence for the effectiveness of mailed nicotine patches in promoting cessation, the findings speak only to the short term effectiveness of this approach...
July 18, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28718291/porous-structured-ni-fe-p-nanocubes-derived-from-prussian-blue-analogue-as-electrocatalyst-for-efficient-overall-water-splitting
#12
Cuijuan Xuan, Jie Wang, Weiwei Xia, Zongkai Peng, Zexing Wu, Wen Lei, Kedong Xia, Huolin L Xin, Deli Wang
Exploring non-precious metal electrocatalysts to replace the noble metal based catalysts for full water electrocatalysis is still an ongoing challenge. In this work, porous structured ternary nickel-iron-phosphides (Ni-Fe-P) nanocubes were synthesized through one-step phosphidation of Ni-Fe based Prussian blue analogue. The Ni-Fe-P nanocubes exhibit rough and loose porous structure on the surface under suitable phosphating temperature, which is favorable for the mass transfer and oxygen diffusion during electrocatalysis process...
July 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28717239/a-novel-pathogen-capturing-device-for-removal-and-detection
#13
Gwangseong Kim, Horatiu Vinerean, Angelo Gaitas
A simple technique that employs an antibody coated polydimethylsiloxane tube is used for effective capturing of bloodborne and foodborne pathogens. By recirculating the entire sample through the antibody coated tube, accumulation of target pathogens is achieved, thereby delivering a higher concentration of pathogens in a small volume. The described method can provide an effective and economical solution to microbiology techniques that rely on enrichment, thereby expediting diagnostics. Using this method 80...
July 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28716001/variant-ranker-a-web-tool-to-rank-genomic-data-according-to-functional-significance
#14
John Alexander, Dimitris Mantzaris, Marianthi Georgitsi, Petros Drineas, Peristera Paschou
BACKGROUND: The increasing volume and complexity of high-throughput genomic data make analysis and prioritization of variants difficult for researchers with limited bioinformatics skills. Variant Ranker allows researchers to rank identified variants and determine the most confident variants for experimental validation. RESULTS: We describe Variant Ranker, a user-friendly simple web-based tool for ranking, filtering and annotation of coding and non-coding variants...
July 17, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28714273/%C3%AE-catenin-regulation-of-farnesoid-x-receptor-signaling-and-bile-acid-metabolism-during-murine-cholestasis
#15
Michael D Thompson, Akshata Moghe, Pamela Cornuet, Rebecca Marino, Jianmin Tian, Pengcheng Wang, Xiaochao Ma, Marc Abrams, Joseph Locker, Satdarshan P S Monga, Kari Nejak-Bowen
Cholestatic liver diseases result from impaired bile flow and are characterized by inflammation, atypical ductular proliferation (ADP), and fibrosis. The Wnt/β-catenin pathway plays a role in bile duct development, yet its role in cholestatic injury remains indeterminate. Liver-specific β-catenin knockout (KO) mice and wild-type (WT) littermates were subjected to cholestatic injury via bile duct ligation or short-term exposure to 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) diet. Intriguingly, KO exhibit a dramatic protection from liver injury, fibrosis, and ADP, which coincided with significantly decreased total hepatic bile acids (BA)...
July 17, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28713657/290-metagenome-assembled-genomes-from-the-mediterranean-sea-a-resource-for-marine-microbiology
#16
Benjamin J Tully, Rohan Sachdeva, Elaina D Graham, John F Heidelberg
The Tara Oceans Expedition has provided large, publicly-accessible microbial metagenomic datasets from a circumnavigation of the globe. Utilizing several size fractions from the samples originating in the Mediterranean Sea, we have used current assembly and binning techniques to reconstruct 290 putative draft metagenome-assembled bacterial and archaeal genomes, with an estimated completion of ≥50%, and an additional 2,786 bins, with estimated completion of 0-50%. We have submitted our results, including initial taxonomic and phylogenetic assignments, for the putative draft genomes to open-access repositories for the scientific community to use in ongoing research...
2017: PeerJ
https://www.readbyqxmd.com/read/28712566/left-habenular-activity-attenuates-fear-responses-in-larval-zebrafish
#17
Erik R Duboué, Elim Hong, Kiara C Eldred, Marnie E Halpern
Fear responses are defensive states that ensure survival of an organism in the presence of a threat. Perception of an aversive cue causes changes in behavior and physiology, such as freezing and elevated cortisol, followed by a return to the baseline state when the threat is evaded [1]. Neural systems that elicit fear behaviors include the amygdala, hippocampus, and medial prefrontal cortex. However, aside from a few examples, little is known about brain regions that promote recovery from an aversive event [2]...
July 8, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28711854/exploration-of-the-possible-effect-on-survival-of-lead-time-associated-with-implementation-of-cancer-patient-pathways-among-symptomatic-first-time-cancer-patients-in-denmark
#18
Henry Jensen, Peter Vedsted
BACKGROUND: Implementation of standardised cancer patient pathways (CPPs) has provided faster diagnosis of cancer. Cancer survival has improved during the same time period. Concern has been raised that the faster diagnosis may have introduced lead-time bias by elongating the period from diagnosis to death. AIM: We aimed to analyse the possible effect of lead time on survival due to expedited cancer diagnosis after the implementation of national CPPs among incident cancer patients diagnosed through Danish primary care...
July 13, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28711483/a-multistage-subunit-vaccine-effectively-protects-mice-against-primary-progressive-tuberculosis-latency-and-reactivation
#19
Jilei Ma, Xindong Teng, Xiaochun Wang, Xionglin Fan, Yaqi Wu, Maopeng Tian, Zijie Zhou, Longmeng Li
Adult tuberculosis (TB) is the main cause of TB epidemic and death. The infection results mainly by endogenous reactivation of latent TB infection and secondarily transmitted by exogenous infection. There is no vaccine for adult TB. To this end, we first chose antigens from a potential antigenic reservoir. The antigens strongly recognized T cells from latent and active TB infections that responded to antigens expressed by Mycobacterium tuberculosis cultured under different metabolic states. Fusions of single-stage polyprotein CTT3H, two-stage polyprotein A1D4, and multistage CMFO were constructed...
July 8, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28711370/assessing-the-risk-of-hypercalcemic-crisis-in-patients-with-primary-hyperparathyroidism
#20
Andrew J Lowell, Norah M Bushman, Xing Wang, Yue Ma, Susan C Pitt, Rebecca S Sippel, David F Schneider, Reese W Randle
BACKGROUND: Hypercalcemic crisis (HC) is a potentially life-threatening manifestation of primary hyperparathyroidism (PHPT). This study aimed to identify patients with PHPT at greatest risk for developing HC. METHODS: This retrospective cohort study included patients with a preoperative calcium of at least 12 mg/dL undergoing initial parathyroidectomy for PHPT from 11/2000 to 03/2016. We compared those with HC, defined as needing hospitalization for hypercalcemia, to those without HC...
July 12, 2017: Journal of Surgical Research
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