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https://www.readbyqxmd.com/read/28086746/mviaeval-a-web-tool-for-comprehensively-evaluating-the-performance-of-a-new-missing-value-imputation-algorithm
#1
Wei-Sheng Wu, Meng-Jhun Jhou
BACKGROUND: Missing value imputation is important for microarray data analyses because microarray data with missing values would significantly degrade the performance of the downstream analyses. Although many microarray missing value imputation algorithms have been developed, an objective and comprehensive performance comparison framework is still lacking. To solve this problem, we previously proposed a framework which can perform a comprehensive performance comparison of different existing algorithms...
January 13, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28081047/the-challenges-of-implementing-and-evaluating-prescription-expedited-partner-treatment
#2
Patricia J Kissinger
No abstract text is available yet for this article.
February 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28079746/sentinel-surveillance-for-expedited-partner-therapy-prescriptions-using-pharmacy-data-in-2-new-york-city-neighborhoods-2015
#3
Ebiere Okah, Vibhuti Arya, Meighan Rogers, Michelle Kim, Julia Ann Schillinger
BACKGROUND: Expedited partner therapy (EPT) for Chlamydia trachomatis (Ct) is the practice of providing Ct-infected patients with medication, or prescription (prescription-EPT) to deliver to their sex partners without first examining those partners. New York City (NYC) providers commonly use prescription-EPT, yet NYC pharmacists report only occasional receipt of EPT prescriptions. This project assessed the frequency of EPT prescriptions filled in 2 NYC neighborhoods. METHODS: The 2 NYC facilities reporting the most frequent use of prescription-EPT were identified from Ct provider case reports and contacted to ascertain their EPT practices...
February 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28079553/end-of-life-decisions-in-heart-failure-to-turn-off-the-intracardiac-device-or-not
#4
Bilal Ayach, Amrit Malik, Colette Seifer, Shelley Zieroth
PURPOSE OF REVIEW: Heart failure is a significant public health concern around the world. Implantable cardioverter defibrillators with or without cardiac resynchronization therapy (CRT-D) have proven survival benefit. As patients progress to end-stage disease, management shifts to palliative care, and cardiologists are often confronted with how to best manage these devices. RECENT FINDINGS: Studies suggest that up to one-third of patients with an implantable cardioverter defibrillator receive painful shocks in the last 24 h of life...
January 11, 2017: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/28078718/fabric-based-alkaline-direct-formate-microfluidic-fuel-cells
#5
Kryls Domalaon, Catherine Tang, Alex Mendez, Franky Bernal, Krutarth Purohit, Linda Pham, John Haan, Frank A Gomez
Fabric-based microfluidic fuel cells (MFCs) serve as a novel, cost-efficient alternative to traditional FCs and batteries, since fluids naturally travel across fabric via capillary action, eliminating the need for an external pump and lowering production and operation costs. Building on previous research with Y-shaped paper-based MFCs, fabric-based MFCs mitigate fragility and durability issues caused by long periods of fuel immersion. In the present work we describe a microfluidic fabric-based direct formate fuel cell (DFFC), with 5 M potassium formate and 30% hydrogen peroxide as the anode fuel and cathode oxidant, respectively...
January 12, 2017: Electrophoresis
https://www.readbyqxmd.com/read/28076851/pse-analysis-a-python-package-for-dna-rna-and-protein-peptide-sequence-analysis-based-on-pseudo-components-and-kernel-methods
#6
Bin Liu, Hao Wu, Deyuan Zhang, Xiaolong Wang, Kuo-Chen Chou
To expedite the pace in conducting genome/proteome analysis, we have developed a Python package called Pse-Analysis. The powerful package can automatically complete the following five procedures: (1) sample feature extraction, (2) optimal parameter selection, (3) model training, (4) cross validation, and (5) evaluating prediction quality. All the work a user needs to do is to input a benchmark dataset along with the query biological sequences concerned. Based on the benchmark dataset, Pse-Analysis will automatically construct an ideal predictor, followed by yielding the predicted results for the submitted query samples...
January 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/28074348/challenges-and-opportunities-in-the-development-of-hiv-medications-in-pediatric-patients
#7
Gueorgui Dubrocq, Natella Rakhmanina, B Ryan Phelps
Successful management of pediatric HIV disease requires high therapeutic efficacy and adherence, which can be achieved by providing affordable, easy to store, and palatable antiretrovirals. Current challenges in pediatric antiretroviral drug development include poor palatability, large pill size, limited oral liquid formulations, and few incentives for development by drug manufacturers as the number of children with HIV continues to decline due to successful worldwide preventive interventions and improved access to antiretrovirals...
January 10, 2017: Paediatric Drugs
https://www.readbyqxmd.com/read/28073504/distribution-of-dinophysis-species-and-their-association-with-lipophilic-phycotoxins-in-plankton-from-the-argentine-sea
#8
Elena Fabro, Gastón O Almandoz, Martha Ferrario, Urban Tillmann, Allan Cembella, Bernd Krock
Dinophysis is a cosmopolitan genus of marine dinoflagellates, considered as the major proximal source of diarrheic shellfish toxins and the only producer of pectenotoxins (PTX). From three oceanographic expeditions carried out during autumn, spring and late summer along the Argentine Sea (∼38-56°S), lipophilic phycotoxins were determined by liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) in size-fractionated plankton samples. Lipophilic toxin profiles were associated with species composition by microscopic analyses of toxigenic phytoplankton...
November 2016: Harmful Algae
https://www.readbyqxmd.com/read/28071640/innovation-in-chemotherapy-administration-process
#9
A Aziz
INTRODUCTION: This project was started after patient's complaints of increased cost burden on patients with increase stay of patient in hospital for chemotherapy administration for 3-4 days, how to decrease this hospital stay and financial burden and how can we improve services to decrease hospital stay and expedite the process of chemotherapy administration. METHODS: A total of 100 patients' confidential files reviewed from February 12, 2013 to May 15, 2013, patients, who were admitted for chemotherapy administration only in inpatient area and all services timings, were reviewed and documented on sheet named as delays chemotherapy sheet, nine processes timings checked against their benchmarks...
April 2016: Indian Journal of Cancer
https://www.readbyqxmd.com/read/28070150/pediatric-neurology-briefs-year-in-review
#10
COMMENT
John J Millichap
Pediatric Neurology Briefs (PNB) has been published monthly since 1987 as a continuing education service designed to expedite and facilitate review of current medical literature concerning pediatric neurology.
January 2017: Pediatric neurology briefs
https://www.readbyqxmd.com/read/28067782/rna-interference-for-mosquito-and-mosquito-borne-disease-control
#11
REVIEW
Paul M Airs, Lyric C Bartholomay
RNA interference (RNAi) is a powerful tool to silence endogenous mosquito and mosquito-borne pathogen genes in vivo. As the number of studies utilizing RNAi in basic research grows, so too does the arsenal of physiological targets that can be developed into products that interrupt mosquito life cycles and behaviors and, thereby, relieve the burden of mosquitoes on human health and well-being. As this technology becomes more viable for use in beneficial and pest insect management in agricultural settings, it is exciting to consider its role in public health entomology...
January 5, 2017: Insects
https://www.readbyqxmd.com/read/28067402/ontogenetic-timing-as-a-condition-dependent-life-history-trait-high-condition-males-develop-quickly-peak-early-and-age-fast
#12
Amy K Hooper, Foteini Spagopoulou, Zachariah Wylde, Alexei A Maklakov, Russell Bonduriansky
Within-population variation in ageing remains poorly understood. In males, condition-dependent investment in secondary sexual traits may incur costs which limit ability to invest in somatic maintenance. Moreover, males often express morphological and behavioural secondary sexual traits simultaneously, but the relative effects on ageing of investment in these traits remain unclear. We investigated the condition-dependence of male life history in the neriid fly Telostylinus angusticollis. Using a fully factorial design, we manipulated male early-life condition by varying nutrient content of the larval diet and, subsequently, manipulated opportunity for adult males to interact with rival males...
January 9, 2017: Evolution; International Journal of Organic Evolution
https://www.readbyqxmd.com/read/28065953/self-evaluation-of-ethical-review-committees-functioning-at-foundation-university-medical-college-fumc-through-structured-constitution-practice-outcome-cpo-assessment-model
#13
Sadia Ahsin, Gul E Naghma Saeed
OBJECTIVE: To assess the operational efficiency of the ethical review committee of a medical college. METHODS: This study was conducted at the Foundation University Medical College, Islamabad, Pakistan, from 2012 to 2014. On the basis of literature review, methods for assessment of various features of ethical review committee were studied. A constitution-practice-outcome measurement model for evaluation of ethical review committee assessment process was developed...
January 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28063000/evaluation-of-loop-mediated-isothermal-amplification-for-the-rapid-identification-of-bacteria-and-resistance-determinants-in-positive-blood-cultures
#14
J Rödel, J A Bohnert, S Stoll, L Wassill, B Edel, M Karrasch, B Löffler, W Pfister
The use of molecular assays to rapidly identify pathogens and resistance genes directly from positive blood cultures (BCs) contribute to shortening the time required for the diagnosis of bloodstream infections. In this work, loop-mediated isothermal amplification (LAMP) assays have been examined for their potential use in BC diagnosis. Three different assays were applied. The commercially available eazyplex® MRSA test detects Staphylococcus aureus, S. epidermidis, mecA, and mecC. Two in-house assays [Gram-positive (GP) and Gram-negative (GN)] have been developed for the detection of streptococci, enterococci, vanA, vanB, Pseudomonas spp...
January 6, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28062820/epidemiology-diagnosis-and-treatment-of-scabies-in-a-dermatology-office
#15
Kathryn L Anderson, Lindsay C Strowd
BACKGROUND: Scabies is a neglected skin disease, and little is known about current incidence and treatment patterns in the United States. The purpose of this study was to examine demographic data, treatment types, success of treatment, and misdiagnosis rate of scabies in an outpatient dermatology clinic. METHODS: A retrospective chart review of patients diagnosed with scabies within the past 5 years was performed. RESULTS: A total of 459 charts were identified, with 428 meeting inclusion criteria...
January 2017: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/28062614/myocardial-infarction-type-2-and-myocardial-injury
#16
REVIEW
Yader Sandoval, Kristian Thygesen
BACKGROUND: The development and implementation of sensitive and high-sensitivity cardiac troponin assays has not only expedited the early ruling in and ruling out of acute myocardial infarction, but has also contributed to the identification of patients at risk for myocardial injury with necrosis, as confirmed by the presence of cardiac troponin concentrations above the 99th percentile. Myocardial injury with necrosis may occur either in the presence of overt ischemia from myocardial infarction, or in the absence of overt ischemia from myocardial injury accompanying other conditions...
January 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28061890/hpv-dna-in-saliva-from-patients-with-scc-of-the-head-and-neck-is-specific-for-p16-positive-oropharyngeal-tumours
#17
Jason K Wasserman, Ryan Rourke, Bibianna Purgina, Lisa Caulley, Jim Dimitroulakis, Martin Corsten, Stephanie Johnson-Obaseki
BACKGROUND: Human papillomavirus (HPV) is an important cause of head and neck squamous cell carcinoma (HNSCC), especially in young people. These tumours overexpress p16 and respond well to treatment. The rapid detection of HPV in patients with HNSCC may expedite treatment when p16 status is not immediately available. METHODS: Saliva-based DNA collection kits and nested polymerase chain reaction (PCR) were used to determine the HPV status of 62 individuals with biopsy-proven HNSCC...
January 6, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28061634/personalized-medicine-approach-for-an-exceptional-response-to-multiple-recurrent-and-metastatic-her2-positive-oropharyngeal-squamous-cell-carcinoma
#18
Nolan B Seim, Stephen Y Kang, Milan Bhandari, Riley G Jones, Theodoros N Teknos
INTRODUCTION: Advanced stage squamous cell carcinoma of the head and neck carries an overall poor prognosis, and survivorship gains have remained relatively stagnant compared to other malignancies due to its complex tumor biology and lack of proven effective targeting agents. METHODS: We present a case of an exceptional responder to molecular-targeted therapy for metastatic oropharyngeal squamous cell carcinoma using a chemotherapeutic agent FDA approved for breast cancer and targeting the HER2/Neu receptor in order to discuss the larger clinical implications...
January 1, 2017: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/28059693/tightrope-walking-towards-maximising-secondary-uses-of-digitised-health-data-a-qualitative-study
#19
Ann R R Robertson, Pam Smith, Harpreet S Sood, Kathrin Cresswell, Ulugbek Nurmatov Nurmatov, Aziz Sheikh
BACKGROUND: Timely progress with attaining benefits from Health Information Technology (HIT) investments requires UK policymakers and others to negotiate challenges in developing structures and processes to catalyse the trustworthy secondary uses of HIT-derived data. AIMS: We aimed to uncover expert insights into perceived barriers and facilitators for maximising safe and secure secondary uses of HIT-derived data in the UK. METHODS: We purposively selected individuals from a range of disciplines in the UK and abroad to participate in a thematically analysed, semi-structured interview study...
October 12, 2016: Journal of Innovation in Health Informatics
https://www.readbyqxmd.com/read/28059431/evaluation-of-treatment-changes-following-electronic-consultation-to-a-pharmacist-run-urine-drug-testing-service-in-a-veterans-healthcare-system
#20
Michelle M Stammet, Shelley S Spradley
In 2013, the North Florida/South Georgia Veterans Healthcare System established a pharmacist-run urine drug testing (UDT) electronic consultation (e-consult) service to assist providers with interpretation of this useful yet complex clinical tool. This pilot study aimed to classify clinical treatment changes implemented following e-consult to a pharmacist-run UDT service and analyze factors limiting pharmacist intervention postconsultation. One hundred forty-three e-consults were completed in the 2-year study period including interpretation of 190 UDT results classified as expected, unexpected, or not necessarily inappropriate based on prescription profile at time of urine immunoassay test...
November 2016: Journal of Opioid Management
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