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hydrochlorothiazide

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https://www.readbyqxmd.com/read/29663016/gallic-acid-a-phenolic-compound-isolated-from-mimosa-bimucronata-dc-kuntze-leaves-induces-diuresis-and-saluresis-in-rats
#1
Fabile Schlickmann, Thaise Boeing, Luisa Nathália Bolda Mariano, Rita de Cássia Melo Vilhena de Andrade Fonseca da Silva, Luisa Mota da Silva, Sérgio Faloni de Andrade, Priscila de Souza, Valdir Cechinel-Filho
Although present in the leaves of Mimosa bimucronata (DC.) and many other medicinal plants commonly used to augment urinary volume excretion, the effects of gallic acid as a diuretic agent remain to be studied. Wistar rats were orally treated with vehicle, hydrochlorothiazide, or gallic acid. The effects of gallic acid in the presence of hydrochlorothiazide, furosemide, amiloride, L-NAME, atropine, and indomethacin were also investigated. Diuretic index, pH, conductivity, and electrolyte excretion were evaluated at the end of the experiment (after 8 or 24 h)...
April 16, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29653073/a-zebrafish-heart-failure-model-for-assessing-therapeutic-agents
#2
Xiao-Yu Zhu, Si-Qi Wu, Sheng-Ya Guo, Hua Yang, Bo Xia, Ping Li, Chun-Qi Li
Heart failure is a leading cause of death and the development of effective and safe therapeutic agents for heart failure has been proven challenging. In this study, taking advantage of larval zebrafish, we developed a zebrafish heart failure model for drug screening and efficacy assessment. Zebrafish at 2 dpf (days postfertilization) were treated with verapamil at a concentration of 200 μM for 30 min, which were determined as optimum conditions for model development. Tested drugs were administered into zebrafish either by direct soaking or circulation microinjection...
March 20, 2018: Zebrafish
https://www.readbyqxmd.com/read/29650764/genetic-variants-influencing-plasma-renin-activity-in-hypertensive-patients-from-the-pear-study-pharmacogenomic-evaluation-of-antihypertensive-responses
#3
Caitrin W McDonough, Oyunbileg Magvanjav, Ana C C Sá, Nihal M El Rouby, Chintan Dave, Amelia N Deitchman, Marina Kawaguchi-Suzuki, Wenbin Mei, Yong Shen, Ravi Shankar Prasad Singh, Mohamed Solayman, Kent R Bailey, Eric Boerwinkle, Arlene B Chapman, John G Gums, Amy Webb, Steven E Scherer, Wolfgang Sadee, Stephen T Turner, Rhonda M Cooper-DeHoff, Yan Gong, Julie A Johnson
BACKGROUND: Plasma renin is an important regulator of blood pressure (BP). Plasma renin activity (PRA) has been shown to correlate with variability in BP response to antihypertensive agents. We conducted a genome-wide association study to identify single-nucleotide polymorphisms (SNPs) associated with baseline PRA using data from the PEAR study (Pharmacogenomic Evaluation of Antihypertensive Responses). METHODS: Multiple linear regression analysis was performed in 461 whites and 297 blacks using an additive model, adjusting for age, sex, and ancestry-specific principal components...
April 2018: Circulation. Genomic and precision medicine
https://www.readbyqxmd.com/read/29642551/n-aryl-7-hydroxy-5-oxo-2-3-dihydro-1h-5h-pyrido-3-2-1-ij-quinoline-6-carboxamides-the-synthesis-and-effects-on-urinary-output
#4
Igor V Ukrainets, Lyudmila V Sidorenko, Mykola Y Golik, Igor M Chernenok, Lina A Grinevich, Alexandra A Davidenko
Continuing a targeted search for new leading structures with diuretic action among tricyclic derivatives of hydroxyquinolines, which are of interest as potential inhibitors of aldosterone synthase, the synthesis of a series of the corresponding pyrido[3,2,1- ij ]quinoline-6-carboxanilides was carried out by amidation of ethyl-7-hydroxy-5-oxo-2,3-dihydro-1 H ,5 H -pyrido[3,2,1- ij ]quinoline-6-carboxylate with aniline, aminophenols and O -alkylsubstituted analogs with high yields and purity. The optimal conditions of this reaction are proposed; they make it possible to prevent partial destruction of the original heterocyclic ester and thereby avoid formation of specific impurities of 7-hydroxy-2,3-dihydro-1 H ,5 H -pyrido[3,2,1- ij ]quinolin-5-one...
April 9, 2018: Scientia Pharmaceutica
https://www.readbyqxmd.com/read/29626975/a-77-year-old-woman-with-acute-shortness-of-breath-and-chest-pain
#5
Ryan Hyde, Julian Chung, Jason Chertoff, Hassan Alnuaimat, Ali Ataya
A 77-year-old woman presented to the hospital with symptoms of progressive shortness of breath with associated right-sided pleuritic pain. The patient had begun noting dyspnea on exertion, limiting her ability to go on hikes over the few days prior to admission. Her medical history is significant for carcinoid tumor status postresection in 2012 without recurrence. She has no history of thromboembolism or clotting disorders, and she has no history of smoking or drug abuse. Current medications include amlodipine, celecoxib, hydrochlorothiazide, and rosuvastatin...
April 2018: Chest
https://www.readbyqxmd.com/read/29621714/removal-of-pharmaceuticals-in-urban-wastewater-high-rate-algae-pond-hrap-based-technologies-as-an-alternative-to-activated-sludge-based-processes
#6
Elena Villar-Navarro, Rosa M Baena-Nogueras, Maria Paniw, José A Perales, Pablo A Lara-Martín
Microalgae biotechnology is a promising tool for many applications, including the elimination of nutrients and other contaminants from wastewater. In this work, we measured the removal efficiency of two wastewater treatment processes: an activated-sludge based conventional process and another based on microalgae biotechnology using high-rate algae ponds (HRAPs). The latter was tested using two different configurations. In the first one, HRAPs were placed after an UASB reactor and used as a tertiary treatment to remove nutrients...
March 29, 2018: Water Research
https://www.readbyqxmd.com/read/29610608/pharmacotherapy-evaluation-and-utilization-in-coronary-artery-bypass-grafting-patients-in-kosovo-during-the-period-2016-2017
#7
Armond Daci, Adnan Bozalija, Raif Cavolli, Rame Alaj, Giangiacomo Beretta, Shaip Krasniqi
BACKGROUND: Coronary Artery Bypass Grafting (CABG) is realised in patients with critical or advanced disease of coronary arteries. There are different pharmacotherapeutic approaches which are used as management, treatment and preventive therapy in cardiovascular disease or related comorbidities. Performing a successful surgery, pharmacotherapy, and increase of bypass patency rate remains a serious challenge. AIM: This study aims to analyse the patient characteristics undergoing CABG and evaluation of their drug utilisation rate and daily dosages in the perioperative period...
March 15, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29609685/stability-of-regularly-prescribed-oral-liquids-formulated-with-syrspend-%C3%A2-sf
#8
M Uriel, C Gómez-Rincón, D Marro
The purpose of this research was to evaluate the stability of 12 oral liquid formulations frequently compounded in hospital and community settings formulated in a specific vehicle: SyrSpend® SF. The stability of melatonin, glycopyrrolate, ciclosporin, chloral hydrate, flecainide acetate, tiagabine HCl, labetalol HCl, ciprofloxacin HCl, spironolactone/hydrochlorothiazide, hydrocortisone, itraconazole and celecoxib in SyrSpend SF PH4 (liquid) was investigated at 0, 30, 60 and 90 days and stored at both controlled room temperature and refrigerated...
April 2, 2018: Die Pharmazie
https://www.readbyqxmd.com/read/29604332/effects-of-hydrochlorothiazide-and-amlodipine-on-single-oral-dose-pharmacokinetics-of-valsartan-in-healthy-korean-subjects-population-model-based-approach
#9
Lien Ngo, Hea-Young Cho, Yong-Bok Lee
Fixed dose combination (FDC) of valsartan (VAL) and hydrochlorothiazide (HCT) or VAL and amlodipine (AML) has been available in many countries for the treatment of hypertension. Due to drug-drug interaction potentials, in the current study we aimed to evaluate potent effects of HCT and AML on pharmacokinetics (PKs) of VAL when they are orally co-administered as FDC (VAL/HCT at 80/12.5 mg or 160/12.5 mg; and VAL/AML at 160/5 mg or 160/10 mg) products in healthy Korean subjects. Population pharmacokinetic (PK) modeling and analysis were performed by the nonlinear mixed-effects modeling software...
March 28, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29594606/simultaneous-determination-of-captopril-and-hydrochlorothiazide-by-using-a-carbon-ionic-liquid-electrode-modified-with-copper-hydroxide-nanoparticles
#10
Ghodratollah Absalan, Morteza Akhond, Raziye Karimi, Amir M Ramezani
A carbon electrode modified with the ionic liquid octylpyridinium hexafluorophosphate and copper hydroxide nanoparticles was employed in an electrochemical assay for simultaneous determination of captopril (CPT) and hydrochlorothiazide (HCT). The electrode showed two well-defined oxidation peaks for CPT (at 0.22 V) and HCT (at 0.73 V, both vs. Ag/AgCl) at pH 8.0 using square wave voltammetry. Calibration plots are linear in the concentration ranges of 0.7-70 µM (CPT) and 3-600 μM (HCT), with detection limits of 12 and 60 nM, respectively...
January 10, 2018: Mikrochimica Acta
https://www.readbyqxmd.com/read/29580174/effect-of-hydrochlorothiazide-on-serum-uric-acid-concentration-a-genome-wide-association-study
#11
Eero M Ala-Mutka, Jenni M Rimpelä, Frej Fyhrquist, Kimmo K Kontula, Timo P Hiltunen
AIM: To recognize genetic associations of hydrochlorothiazide-induced change in serum uric acid (SUA) concentration. PATIENTS & METHODS: We conducted a genome-wide association study on hydrochlorothiazide-induced change in SUA in 214 Finnish men from the GENRES study. Replication analyses were performed in 465 Finns from the LIFE study. RESULTS: In GENRES, we identified 31 loci associated with hydrochlorothiazide-induced change in SUA at p < 5 × 10-5 ...
March 27, 2018: Pharmacogenomics
https://www.readbyqxmd.com/read/29558036/comparison-of-the-anticonvulsant-potency-of-various-diuretic-drugs-in-the-maximal-electroshock-induced-seizure-threshold-test-in-mice
#12
Katarzyna Załuska, Maria W Kondrat-Wróbel, Jarogniew J Łuszczki
BACKGROUND: The coexistence of seizures and arterial hypertension requires an adequate and efficacious treatment involving both protection from seizures and reduction of high arterial blood pressure. Accumulating evidence indicates that some diuretic drugs (with a well-established position in the treatment of arterial hypertension) also possess anticonvulsant properties in various experimental models of epilepsy. OBJECTIVES: The aim of this study was to assess the anticonvulsant potency of 6 commonly used diuretic drugs (i...
March 20, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29554245/a-capillary-zone-electrophoresis-method-with-multiresponse-chemometric-optimization-for-the-simultaneous-determination-of-zofenopril-calcium-and-hydrochlorothiazide-in-presence-of-hydrochlorothiazide-major-impurities
#13
Ahmed S Fayed, Mamdouh R Rezk, Hoda M Marzouk, Samah S Abbas
In the present decade, great importance has been focused on the development of green analytical methods (GAM) as eco-friendly techniques. Minimizing the wastes, analysis time, hazardous reagents, sample size and energy are the main important principles for development of GAM. This manuscript describes a green, novel, rapid, accurate and reliable capillary zone electrophoresis method (CZE) for the simultaneous separation and determination of zofenopril calcium (ZOF) and hydrochlorothiazide (HCT) in presence of two major impurities of HCT, namely; chlorothiazide (CT) and salamide (DSA)...
March 15, 2018: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/29552536/spironolactone-induced-unilateral-gynecomastia
#14
Sahana Hadihalli Veeregowda, Jayakumar Jyothinagaram Krishnamurthy, Bhuvana Krishnaswamy, Sarala Narayana
Gynecomastia is benign enlargement of male breast, drug-induced gynecomastia accounts for about 25%. We are reporting a case of spironolactone-induced unilateral gynecomastia. A 52-year-old male patient receiving multiple antihypertensives including hydrochlorothiazide presented with muscle weakness and easy fatigability. Investigations revealed hypokalemia; he was advised to stop hydrochlorothiazide and consume potassium-rich diet; since he did not respond to this, spironolactone was added. The patient improved symptomatically but developed painful swelling of the right breast after 12 months of treatment which was suspected to be spironolactone-induced gynecomastia...
January 2018: International Journal of Applied and Basic Medical Research
https://www.readbyqxmd.com/read/29530222/should-we-switch-from-bendrofluazide-to-chlorthalidone-as-the-initial-treatment-for-hypertension-a-review-of-the-available-medication
#15
Bruce Arroll, Henry Wallace
INTRODUCTION Thiazide diuretics are commonly prescribed in the treatment of hypertension. However, thiazide diuretics may not all be equal in their ability to reduce cardiovascular disease outcomes. AIM To determine if bendroflumethiazide/bendrofluazide, the most commonly used diuretic for hypertension in New Zealand, is as effective as other diuretics in terms of cardiovascular disease outcomes. METHODS Using recent reviews of thiazide-like (chlorthalidone or indapamide) and thiazide-type diuretics (hydrochlorothiazide and bendrofluazide) and a separate search of bendrofluazide, data on cardiovascular disease outcomes was extracted...
June 2017: Journal of Primary Health Care
https://www.readbyqxmd.com/read/29523524/genome-wide-association-study-identifies-the-hmgcs2-locus-to-be-associated-with-chlorthalidone-induced-glucose-increase-in-hypertensive-patients
#16
Sonal Singh, Caitrin W McDonough, Yan Gong, Wael A Alghamdi, Meghan J Arwood, Salma A Bargal, Leanne Dumeny, Wen-Yi Li, Mai Mehanna, Bradley Stockard, Guang Yang, Felipe A de Oliveira, Natalie C Fredette, Mohamed H Shahin, Kent R Bailey, Amber L Beitelshees, Eric Boerwinkle, Arlene B Chapman, John G Gums, Stephen T Turner, Rhonda M Cooper-DeHoff, Julie A Johnson
BACKGROUND: Thiazide and thiazide-like diuretics are first-line medications for treating uncomplicated hypertension. However, their use has been associated with adverse metabolic events, including hyperglycemia and incident diabetes mellitus, with incompletely understood mechanisms. Our goal was to identify genomic variants associated with thiazide-like diuretic/chlorthalidone-induced glucose change. METHODS AND RESULTS: Genome-wide analysis of glucose change after treatment with chlorthalidone was performed by race among the white (n=175) and black (n=135) participants from the PEAR-2 (Pharmacogenomic Evaluation of Antihypertensive Responses-2)...
March 9, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29507752/chlorthalidone-not-hydrochlorothiazide-is-the-right-diuretic-for-comparison
#17
Ravi Tejraj Mehta, Anil Pareek, Indranil Purkait
We have read the study design "Comparison of effects between calcium channel blocker and diuretics in combination with angiotensin II receptor blocker on 24-h central blood pressure and vascular hemodynamic parameters in hypertensive patients: study design for a multicenter, double-blinded, active controlled, phase 4, randomized trial" by Oh GC, et al. with interest. The authors aim to compare the efficacy of amlodipine or hydrochlorothiazide (HCTZ) with an ARB. However, we wish to highlight that chlorthalidone (CTD) is the evidence-based and recommended anti-hypertensive diuretic, and should replace HCTZ in the trial to effectively compare efficacy against the CCB amlodipine...
2018: Clinical Hypertension
https://www.readbyqxmd.com/read/29504252/long-term-efficacy-and-tolerability-of-azilsartan-medoxomil-chlorthalidone-vs-olmesartan-medoxomil-hydrochlorothiazide-in-chronic-kidney-disease
#18
George L Bakris, Lin Zhao, Stuart Kupfer, Attila Juhasz, Michie Hisada, Eric Lloyd, Suzanne Oparil
An open-label, long-term study evaluated safety and tolerability of azilsartan medoxomil/chlorthalidone (AZL-M/CLD) vs olmesartan/hydrochlorothiazide (OLM/HCTZ) in hypertensive participants with stage 3 chronic kidney disease. Initial therapy was AZL-M/CLD 20/12.5 mg (n = 77) or OLM/HCTZ 20/12.5 mg (n = 76), but could be up-titrated (AZL-M/CLD to 40/25 mg; OLM/HCTZ to 40/25 mg [US] or 20/25 mg [Europe]) with other agents added during weeks 4-52. Primary endpoint was proportion of participants with ≥ 1 adverse event (AE) through week 52...
March 4, 2018: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/29504233/treatment-of-hypertension-in-ckd-patients-with-azilsartan-chlorthalidone-vs-olmesartan-hydrochlorothiazide
#19
Walter M van der Merwe
No abstract text is available yet for this article.
March 4, 2018: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/29499348/continuous-manufacturing-and-analytical-characterization-of-fixed-dose-multilayer-orodispersible-films
#20
Yasmin Thabet, Dominique Lunter, Joerg Breitkreutz
Various drug therapies require more than one active pharmaceutical ingredient (API) for an effective treatment. There are many advantages, e.g. to improve the compliance or pharmacodynamic response in comparison to a monotherapy or to increase the therapy safety. Until now, there are only a few products available for the paediatric population due to the lack of age appropriate dosage forms or studies proving the efficacy and safety of these products. This study aims to develop orodispersible films (ODFs) in a continuous solvent casting process as child appropriate dosage form containing both enalapril maleate (EM) and hydrochlorothiazide (HCT) separated in different film layers...
February 27, 2018: European Journal of Pharmaceutical Sciences
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