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https://www.readbyqxmd.com/read/28724547/long-term-effects-of-a-renin-inhibitor-versus-a-thiazide-diuretic-on-arterial-stiffness-and-left-ventricular-diastolic-function-in-elderly-hypertensive-patients
#1
Yoshiyuki Okada, Shigeki Shibata, Naoki Fujimoto, Stuart Alexander Best, Benjamin D Levine, Qi Fu
Arterial stiffness and cardiac function are important predictors of cardiovascular events in patients with hypertension even with adequate blood pressure (BP) control. We evaluated whether a direct renin inhibitor, aliskiren, reduces arterial stiffness and modulates left ventricular function compared with a diuretic, hydrochlorothiazide, in elderly hypertensives. Twenty one hypertensives [67±14 (SD) yrs] were randomly assigned to receive 6-month aliskiren (n=11) or hydrochlorothiazide (n=10) based therapy...
July 19, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28722356/hansen-solubility-parameters-for-assay-method-optimization-of-simvastatin-ramipril-atenolol-hydrochlorothiazide-and-aspirin-in-human-plasma-using-liquid-chromatography-with-tandem-mass-spectrometry
#2
Murali Mohan Reddy Devalapalli, Hanumanth Srikanth Cheruvu, Thejaswi Yertha, Vijaya Bhaskar Veeravalli, Sunitha Sampathi, Savithri Shivakumar
A simple, specific, sensitive validated method was developed using liquid chromatography with tandem mass spectrometry with electrospray ionization of human plasma for the simultaneous estimation of drugs (simvastatin, ramipril, atenolol, hydrochlorothiazide and aspirin) of Polycap(TM) capsule used in cardiovascular therapy. The interaction of these actives including internal standards between the stationary and mobile phase were investigated using Hansen solubility parameters. Chromatographic separation was performed on Phenomenex Synergi Polar-RP (30 × 2 mm, 4 μm) column with a gradient mobile phase composition of acetonitrile and 5 mM ammonium formate for positive mode and 0...
July 19, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28722342/green-micellar-hplc-analysis-of-three-angiotensin-converting-enzyme-inhibitors-in-their-mixtures-with-hydrochlorothiazide-and-modeling-of-their-retention-behavior-by-fitting-to-foley-s-model
#3
Manal Eid, Yasser El-Shabrawy, Rania El-Shaheny
We present an environmentally friendly method for the analysis of three angiotensin-converting enzyme inhibitors and hydrochlorothiazide simultaneously using a green micellar eluent for the first time. The chromatographic separation of enalapril maleate, lisinopril dihydrate, benazepril hydrochloride, and hydrochlorothiazide was implemented on an octadecyl silica column with a solution containing sodium dodecyl sulfate (0.12 M), 1-propyl alcohol (10% v/v), triethylamine (0.3% v/v) and H3 PO4 (0.02 M) at pH 3...
July 19, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28721143/the-effect-of-antihypertensive-treatment-on-arterial-stiffness-and-serum-concentration-of-selected-matrix-metalloproteinases
#4
Marek Rajzer, Wiktoria Wojciechowska, Tomasz Kameczura, Agnieszka Olszanecka, Danuta Fedak, Michał Terlecki, Kalina Kawecka-Jaszcz, Danuta Czarnecka
INTRODUCTION: The aim of the study was to assess the arterial stiffness and serum levels of selected metalloproteinases (MMPs) in hypertensive patients and their changes following antihypertensive therapy. MATERIAL AND METHODS: The study group consisted of 95 patients with essential arterial hypertension (HT) stage 1 or 2 (mean age: 53.1 ±13.0 years). The control group consisted of 31 normotensives of the same age range. Hypertension patients were randomized to one of the following monotherapies for 6 months: quinapril, losartan, amlodipine, hydrochlorothiazide or bisoprolol...
June 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28719636/the-non-diuretic-hypotensive-effects-of-thiazides-are-enhanced-during-volume-depletion-states
#5
Saeed Alshahrani, Robert M Rapoport, Kamyar Zahedi, Min Jiang, Michelle Nieman, Sharon Barone, Andrea L Meredith, John N Lorenz, Jack Rubinstein, Manoocher Soleimani
Thiazide derivatives including Hydrochlorothiazide (HCTZ) represent the most common treatment of mild to moderate hypertension. Thiazides initially enhance diuresis via inhibition of the kidney Na+-Cl- Cotransporter (NCC). However, chronic volume depletion and diuresis are minimal while lowered blood pressure (BP) is maintained on thiazides. Thus, a vasodilator action of thiazides is proposed, likely via Ca2+-activated K+ (BK) channels in vascular smooth muscles. This study ascertains the role of volume depletion induced by salt restriction or salt wasting in NCC KO mice on the non-diuretic hypotensive action of HCTZ...
2017: PloS One
https://www.readbyqxmd.com/read/28711447/the-transition-from-hypertension-to%C3%A2-heart%C3%A2-failure-contemporary-update
#6
REVIEW
Franz H Messerli, Stefano F Rimoldi, Sripal Bangalore
Longstanding hypertension ultimately leads to heart failure (HF), and as a consequence most patients with HF have a history of hypertension. Conversely, absence of hypertension in middle age is associated with lower risks for incident HF across the remaining life course. Cardiac remodeling to a predominant pressure overload consists of diastolic dysfunction and concentric left ventricular (LV) hypertrophy. When pressure overload is sustained, diastolic dysfunction progresses, filling of the concentric remodeled LV decreases, and HF with preserved ejection fraction ensues...
July 6, 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/28706401/influence-of-west-african-ethnicity-and-gender-on-beta-cell-function-and-insulin-sensitivity-in-essential-hypertensives-treated-with-hydrochlorothiazide-and-hydrochlorothiazide-lisinopril-combination
#7
Micheal Olamoyegun, Babatope Kolawole, Adesuyi A L Ajayi
OBJECTIVE: To assess the effects of hydrochlorothiazide (HCT) given alone and in combination with an angiotensin-converting enzyme inhibitor (ACEI) on beta-cell function in a negroid population to further explore possible ethnic differences in the effect of antihypertensive drugs on homeostasis model assessment - insulin resistance (HOMA-IR). MATERIALS AND METHODS: A total of 80 newly diagnosed Nigerian essential hypertensive patients were assigned to receive either HCT 25 mg daily or both HCT and lisinopril (Lis; 25/10 mg daily) in an open-label study for 12 weeks...
April 2017: Journal of Pharmacology & Pharmacotherapeutics
https://www.readbyqxmd.com/read/28703124/comparison-between-the-effects-of-hydrochlorothiazide-and-indapamide-on-the-kidney-in-hypertensive-patients-inadequately-controlled-with-losartan
#8
S Wang, J Li, X Zhou, K Liu, X Zhang, Q Meng, R Shi, D Shi, X Chen
The aim of the study is to compare the effects of hydrochlorothiazide and indapamide on the kidney in patients with hypertension inadequately controlled with losartan. A total of 140 patients who met the criteria and inadequately controlled with losartan 50 mg per day for 2 weeks were randomized in two groups and administered either hydrochlorothiazide 12.5 mg per day (n=70) or indapamide (sustained release) 1.5 mg per day (n=70) in combination with losartan 50 mg per day. Office blood pressure (BP) were collected at baseline and upon each follow-up visit...
July 13, 2017: Journal of Human Hypertension
https://www.readbyqxmd.com/read/28689959/removal-of-nutrients-and-pharmaceuticals-and-personal-care-products-from-wastewater-using-periphyton-photobioreactors
#9
Du Kang, Qichao Zhao, Yonghong Wu, Chenxi Wu, Wu Xiang
In this work, periphyton photobioreactors were built and were used for the treatment of synthetic wastewater spiked with PPCPs under different operational conditions. The removal rates of total nitrogen were relatively stable and varied from 39% to 77% overtime in different treatments. However, the removal rates of soluble reactive phosphorus decreased overtime from 42% to 68% on day 2 to 15.8% to 44% on day 22. For the selected PPCPs, only bisphenol A was effectively removed (72%-86.4%), hydrochlorothiazide and ibuprofen were moderately removed (26...
June 29, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28688451/alignment-of-the-hydrogen-molecule-under-intense-laser-fields
#10
Gary V Lopez, Martin Fournier, Justin Jankunas, Alexandros K Spiliotis, T Peter Rakitzis, David W Chandler
Alignment of the electronically excited E,F state of the H2 molecule is studied using the velocity mapping imaging technique. Photofragment images of H(+) due to the dissociation mechanism that follows the 2-photon excitation into the (E,F; ν = 0, J = 0) electronic state show a strong dependence on laser intensity, which is attributed to the high polarizability anisotropy of the H2 (E,F) state. We observe a marked structure in the angular distribution, which we explain as the interference between the prepared J = 0 and Stark-mixed J = 2 rovibrational states of H2, as the laser intensity increases...
July 7, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28681550/comparison-of-long-term-safety-of-fixed-dose-combinations-azilsartan-medoxomil-chlorthalidone-vs-olmesartan-medoxomil-hydrochlorothiazide
#11
Joel M Neutel, William C Cushman, Eric Lloyd, Bruce Barger, Alison Handley
This 52-week, randomized, open-label study evaluated long-term safety/tolerability of fixed-dose combination azilsartan medoxomil/chlorthalidone (AZL-M/CLD) vs fixed-dose combination olmesartan medoxomil/hydrochlorothiazide (OLM/HCTZ) in patients with essential hypertension (stage 2; clinic systolic blood pressure 160-190 mm Hg). Initial AZL-M/CLD 40/12.5 mg/d (n=418) or OLM/HCTZ 20/12.5 mg/d (n=419) could be uptitrated during weeks 4 to 52 (AZL-M/CLD to 80/25 mg; OLM/HCTZ to 40/25 mg [United States] or 20/25 mg [Europe]) to meet blood pressure targets...
July 6, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28681525/selective-spectrofluorimetric-method-for-determination-of-lisinopril-in-pharmaceutical-preparations-and-in-presence-of-hydrochlorothiazide-application-to-content-uniformity-testing
#12
Sayed M Derayea, Khalid M Badr El-Din, Fatma F Mohammed
A novel sensitive and cost-effective spectrofluorimetric method has been developed and validated for determination of lisinopril (an angiotensin converting enzyme inhibitor) in its pure form and pharmaceutical preparations. The method is based on the reaction of the drug with ninhydrin and phenylacetaldehyde in buffered medium (pH 7.0) to form a highly fluorescent product measured at 460 nm after excitation at 390 nm. Different experimental parameters were optimized and calibration curve was constructed...
July 6, 2017: Luminescence: the Journal of Biological and Chemical Luminescence
https://www.readbyqxmd.com/read/28666228/high-throughput-quantification-of-8-antihypertensive-drugs-and-active-metabolites-in-human-plasma-using-uplc-ms-ms
#13
Bart C H van der Nagel, Jorie Versmissen, Soma Bahmany, Teun van Gelder, Birgit C P Koch
BACKGROUND: To assess drug adherence of patients with hypertension, an analytical method was developed and validated using ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS). The method includes eight frequently prescribed antihypertensive drugs from four classes and their active metabolites: angiotensin converting enzyme inhibitors enalapril and perindopril (active metabolites respectively enalaprilate and perindoprilate), angiotensin II receptor blockers losartan (with the active metabolite losartan carboxylic acid) and valsartan, calcium channel blockers amlodipine and nifedipine and diuretics hydrochlorothiazide and spironolactone (with the active metabolite canrenone)...
June 19, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28647890/comparison-of-lercanidipine-plus-hydrochlorothiazide-vs-lercanidipine-plus-enalapril-on-micro-and-macrocirculation-in-patients-with-mild-essential-hypertension
#14
Carolina De Ciuceis, Massimo Salvetti, Anna Paini, Claudia Rossini, Maria Lorenza Muiesan, Sarah Duse, Stefano Caletti, Maria Antonietta Coschignano, Francesco Semeraro, Valentina Trapletti, Fabio Bertacchini, Valeria Brami, Alina Petelca, Enrico Agabiti Rosei, Damiano Rizzoni, Claudia Agabiti Rosei
Dihydropyridine calcium channel blockers may possess antioxidant properties, and might improve micro and macrovascular structure and function. Combination treatment with an ACE inhibitor may have additional advantages, compared with a thiazide diuretic. The aim of the present study is to investigate the effects of a short-term treatment with lercanidipine, and to compare two combination treatments: lercanidipine + enalapril vs. lercanidipine + hydrochlorothiazide on structural alterations in retinal arterioles, on skin capillary density and on large artery distensibility...
June 24, 2017: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/28635169/potential-drug-drug-interactions-in-older-adults-a-population-based-study
#15
Thalyta Renata Araújo Santos, Erika Aparecida Silveira, Lílian Varanda Pereira, Mércia Pandolfo Provin, Dione Marçal Lima, Rita Goreti Amaral
AIM: To evaluate the potential drug-drug interactions (PDDI) between drugs used by older adults, any associated factors and recommended clinical management. METHODS: A cross-sectional, population-based study was carried out through a home survey of 934 older adults (from December 2009 to April 2010). A questionnaire was applied, and the participants were asked to show all the drugs used and their respective prescriptions, thus providing data to identify polypharmacy, self-medication and PDDI...
June 21, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28631393/comparison-of-thiazide-like-diuretics-versus-thiazide-type-diuretics-a-meta-analysis
#16
REVIEW
Wenjing Liang, Hui Ma, Luxi Cao, Wenjiang Yan, Jingjing Yang
Thiazide diuretics are widely used for the management of hypertension. In recent years, it has been actively debated that there is interchangeability of thiazide-type diuretics hydrochlorothiazide and thiazide-like diuretics including indapamide and chlorthalidone for the treatment of hypertension. With the purpose of seeking out the best thiazide diuretic for clinicians, we summarized the existing evidence on the two types of drugs and conducted a meta-analysis on their efficacy in lowering blood pressure and effects on blood electrolyte, glucose and total cholesterol...
June 19, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28612423/chemiluminescence-selectivity-enhancement-in-the-on-chip-ru-bpy-3-2-system-the-potential-role-of-buffer-type-and-ph-in-the-determination-of-hydrochlorothiazide-in-combined-formulations-and-human-plasma
#17
Afsal Mohammed Kadavilpparampu, Haider A J Al Lawati, Fakhr Eldin O Suliman
A simple and highly selective on-chip Ru(bpy)3(2+) -oxidant chemiluminescence (CL) approach for estimation of a diuretic drug, hydrochlorothiazide (HCZ), in biological fluids was realized in the presence of other fixed-dose combination drugs by manipulating simultaneously the method of active species (Ru(bpy)3(3+) ) production and type of carrier buffer with pH used for the CL reaction. Chemical oxidation processes involved in the Ru(bpy)3(2+) -Ce(IV) CL system have been successfully miniaturised in this study using a microfabricated device to generate Ru(bpy)3(3+) instantaneously...
June 14, 2017: Luminescence: the Journal of Biological and Chemical Luminescence
https://www.readbyqxmd.com/read/28608025/triple-combination-therapies-based-on-olmesartan-a-personalized-therapeutic-approach-to-improve-blood-pressure-control
#18
REVIEW
Massimo Volpe, Caterina Santolamazza, Vittoria Mastromarino, Roberta Coluccia, Allegra Battistoni, Giuliano Tocci
Recent epidemiological surveys have demonstrated that effective and sustained blood pressure (BP) control is achieved in a relatively small proportion of treated hypertensive patients. Indeed, treatment of hypertension represents a key strategy for preventing coronary artery disease, stroke, congestive heart failure and cardiovascular death. Several interventions have been proposed by international guidelines for ameliorating hypertension management and control, mostly including integrated and multi-dimensional pharmacological and non-pharmacological strategies...
June 12, 2017: High Blood Pressure & Cardiovascular Prevention: the Official Journal of the Italian Society of Hypertension
https://www.readbyqxmd.com/read/28601791/effect-of-operational-and-water-quality-parameters-on-conventional-ozonation-and-the-advanced-oxidation-process-o3-h2o2-kinetics-of-micropollutant-abatement-transformation-product-and-bromate-formation-in-a-surface-water
#19
Marc Bourgin, Ewa Borowska, Jakob Helbing, Juliane Hollender, Hans-Peter Kaiser, Cornelia Kienle, Christa S McArdell, Eszter Simon, Urs von Gunten
The efficiency of ozone-based processes under various conditions was studied for the treatment of a surface water (Lake Zürich water, Switzerland) spiked with 19 micropollutants (pharmaceuticals, pesticides, industrial chemical, X-ray contrast medium, sweetener) each at 1 μg L(-1). Two pilot-scale ozonation reactors (4-5 m(3) h(-1)), a 4-chamber reactor and a tubular reactor, were investigated by either conventional ozonation and/or the advanced oxidation process (AOP) O3/H2O2. The effects of selected operational parameters, such as ozone dose (0...
May 11, 2017: Water Research
https://www.readbyqxmd.com/read/28588970/modifying-the-interagency-emergency-health-kit-to-include-treatment-for-non-communicable-diseases-in-natural-disasters-and-complex-emergencies
#20
Marcello Tonelli, Natasha Wiebe, Brian Nadler, Ara Darzi, Shahnawaz Rasheed
The Interagency Emergency Health Kit (IEHK) provides a standard package of medicines and simple medical devices for aid agencies to use in emergencies such as disasters and armed conflicts. Despite the increasing burden of non-communicable diseases (NCDs) in such settings, the IEHK includes few drugs and devices for management of NCDs. Using published data to model the population burden of acute and chronic presentations of NCDs in emergency-prone regions, we estimated the quantity of medications and devices that should be included in the IEHK...
November 2016: BMJ Global Health
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