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https://www.readbyqxmd.com/read/28436727/impact-of-switching-from-different-treatment-regimens-to-a-fixed-dose-combination-pill-polypill-in-patients-with-cardiovascular-disease-or-similarly-high-risk
#1
Melvin Lafeber, Wilko Spiering, Frank Lj Visseren, Diederick E Grobbee, Michiel L Bots, Alice Stanton, Anushka Patel, Dorairaj Prabhakaran, Ruth Webster, Simon Thom, Anthony Rodgers
Aims Cardiovascular fixed-dose combination pills, or polypills, may help address the widespread lack of access and adherence to proven medicines. Initiation of polypill-based care typically entails switching from current separately taken medications. Given the heterogeneity in usual care, there is interest in the impact of polypill treatment across different patterns of prior medication regimen. Methods A total of 2004 participants with established cardiovascular disease or estimated 5-year cardiovascular risk of over 15% were randomised to polypill-based treatment (aspirin 75 mg, simvastatin 40 mg, lisinopril 10 mg and either atenolol 50 mg or hydrochlorothiazide 12...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28429850/association-of-obstructive-sleep-apnea-with-arterial-stiffness-and-nondipping-blood-pressure-in-patients-with-hypertension
#2
Raimundo Jenner, Fernanda Fatureto-Borges, Valéria Costa-Hong, Heno F Lopes, Sandra H Teixeira, Elias Marum, Dante A M Giorgi, Fernanda M Consolim-Colombo, Luiz A Bortolotto, Geraldo Lorenzi-Filho, Eduardo M Krieger, Luciano F Drager
Whether sex influences the association of obstructive sleep apnea (OSA) with markers of cardiovascular risk in patients with hypertension is unknown. In this study, 95 hypertensive participants underwent carotid-femoral pulse wave velocity, 24-hour ambulatory blood pressure monitoring, echocardiogram, and polysomnography after a 30-day standardized treatment with hydrochlorothiazide plus enalapril or losartan. OSA was present in 52 patients. Compared with non-OSA patients, pulse wave velocity values were higher in the OSA group (men: 11...
April 21, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28417439/clinical-pharmacokinetics-of-sacubitril-valsartan-lcz696-a-novel-angiotensin-receptor-neprilysin-inhibitor
#3
REVIEW
Surya Ayalasomayajula, Thomas Langenickel, Parasar Pal, Sreedevi Boggarapu, Gangadhar Sunkara
Sacubitril/valsartan (LCZ696) is indicated for the treatment of heart failure with reduced ejection fraction. Absorption of sacubitril/valsartan and conversion of sacubitril (prodrug) to sacubitrilat (neprilysin inhibitor) was rapid with maximum plasma concentrations of sacubitril, sacubitrilat, and valsartan (angiotensin receptor blocker) reaching within 0.5, 1.5-2.0, and 2.0-3.0 h, respectively. With a two-fold increase in dose, an increase in the area under the plasma concentration-time curve was proportional for sacubitril, ~1...
April 17, 2017: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/28415046/cost-benefit-effectiveness-of-angiotensin-ii-receptor-blockers-in-patients-with-uncomplicated-hypertension-a-comparative-analysis
#4
Alberto Mazza, Antonella Paola Sacco, Danyelle M Townsend, Gianni Bregola, Edgardo Contatto, Isabella Cappello, Laura Schiavon, Emilio Ramazzina, Domenico Rubello
OBJECTIVE: The treatment of hypertensive patients (HTs) requires a long-term commitment of compliance for the patient and resources by the healthcare system. This poses an economic dilemma in countries where universal healthcare is standard. The aim of this study was to evaluate the costs/health benefit and effectiveness of treatment with angiotensin-II receptor blockers (ARBs) in uncomplicated essential hypertension. DESIGN AND METHODS: The daily and annual economic commitment for treating patients with ARBs was estimated using pharmacy dispensing records and the BP-lowering effects of candesartan, irbesartan, losartan, olmesartan, telmisartan and valsartan was evaluated retrospectively...
April 14, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28414680/a-rare-cause-of-abdominal-pain
#5
E M Dauchy, M Modica, N Masri
CASE: A 54 year old woman with hypothyroidism presented with right flank pain that began acutely one week prior to presentation. She was told initially she had a urinary tract infection and treatment resulted in mild symptomatic improvement. The pain returned and she presented to another Emergency Department (ED); and was told the pain was due to constipation. She returned to the ED the next day when her pain worsened and her labs were notable for WBC of 19,000/uL, BUN/Cr of 28/0.75 mg/dL, AST of 31 U/L, ALT of 92 U/L and total bilirubin of 0...
March 2017: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/28409546/clinical-correlation-with-failure-of-endovenous-therapy-for-leg-swelling
#6
Ahmad Alsheekh, Anil Hingorani, Natalie Marks, Yuriy Ostrozhynskyy, Enrico Ascher
Background The development and use of minimally invasive procedures provide improved options for the management of symptoms of chronic venous insufficiency. While many patients with iliac venous occlusive disease and superficial venous insufficiency improve with combined iliac venous stenting and correction of superficial venous reflux, some patients have symptoms which persist. The goal of this study was to identify clinical factors related to persistent symptoms in patients with leg swelling after treatment of both iliac vein stenting and thermal ablation...
January 1, 2017: Vascular
https://www.readbyqxmd.com/read/28406849/current-management-practices-in-m%C3%A3-ni%C3%A3-re-s-disease
#7
Joseph W Clyde, Benjamin S Oberman, Huseyin Isildak
OBJECTIVE: To evaluate current trends in managing Ménière's disease (MD) by both general otolaryngologists and otologists/neurotologists and discuss treatment modalities. STUDY DESIGN: Cross-sectional study. SETTING: Survey of physicians. SUBJECTS AND METHODS: An electronic questionnaire was disseminated to all members of American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS). RESULTS: Eight hundred and sixty members replied for a response rate of 14...
April 11, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28390725/comparison-of-a-commercially-available-oral-nutritional-supplement-and-intravenous-fluid-therapy-for-dehydration-in-dairy-calves
#8
Jared D Taylor, Merel Rodenburg, Timothy A Snider
Calf scours is a primary cause of morbidity and mortality in the dairy industry. Effective treatments are needed to minimize death, maximize welfare, and maintain growth and productivity. The objective of this trial was to compare the efficacy of a commercially available nutritional supplement (Diaque, Boehringer-Ingelheim Vetmedica Inc., St. Joseph, MO) and i.v. lactated Ringer's solution (LRS) in rehydrating, preventing acidemia, and correcting electrolyte imbalances in an experimental model for calf scours...
April 5, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28388724/thiazide-treatment-in-primary-hyperparathyroidism-a-new-indication-for-an-old-medication
#9
Gloria Tsvetov, Dania Hirsch, Ilan Shimon, Carlos Benbassat, Hiba Masri-Iraqi, Alexander Gorshtein, Dana Herzberg, Tzippy Shochat, Ilana Shraga-Slutzky, Talia Diker-Cohen
Context: There is no therapy for control of hypercalciuria in nonoperable patients with primary hyperparathyroidism (PHPT). Thiazides are used for idiopathic hypercalciuria but are avoided in PHPT to prevent exacerbating hypercalcemia. Nevertheless, several reports suggested that thiazides may be safe in patients with PHPT. Objective: To test the safety and efficacy of thiazides in PHPT. Design: Retrospective analysis of medical records. Setting: Endocrine clinic at a tertiary hospital...
April 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28383024/multiple-mechanisms-are-involved-in-salt-sensitive-hypertension-induced-renal-injury-and-interstitial-fibrosis
#10
Shi-Yao Wei, Yu-Xiao Wang, Qing-Fang Zhang, Shi-Lei Zhao, Tian-Tian Diao, Jian-Si Li, Wen-Rui Qi, Yi-Xin He, Xin-Yu Guo, Man-Zhu Zhang, Jian-Yu Chen, Xiao-Ting Wang, Qiu-Ju Wei, Yu Wang, Bing Li
Salt-sensitive hypertension (SSHT) leads to kidney interstitial fibrosis. However, the potential mechanisms leading to renal fibrosis have not been well investigated. In present study, Dahl salt-sensitive (DS) rats were divided into three groups: normal salt diet (DSN), high salt diet (DSH) and high salt diet treated with hydrochlorothiazide (HCTZ) (DSH + HCTZ). A significant increase in systolic blood pressure (SBP) was observed 3 weeks after initiating the high salt diet, and marked histological alterations were observed in DSH rats...
April 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28356292/responses-of-distal-nephron-na-transporters-to-acute-volume-depletion-and-hyperkalemia
#11
Gustavo Frindt, Lei Yang, Shinichi Uchida, Alan M Weinstein, Lawrence G Palmer
We assessed effects of acute volume reductions induced by administration of diuretics in rats. Direct block Na+ transport produced changes in urinary electrolyte excretion. Adaptations to these effects appeared as alterations in the expression of protein for the distal nephron Na+ transporters NCC and ENaC. Two hours after a single injection of furosemide (6 mg/kg) or hydrochlorothiazide (30 mg/kg) Na+ and K+ excretion increased but no changes in the content of activated forms of NCC (phosphorylated on residue T53) or ENaC (cleaved γ-subunit) were detected...
March 29, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28343298/thiazide-increases-serum-calcium-in-anuric-patients-the-role-of-parathyroid-hormone
#12
Raquel F V Vasco, Eduardo T Reis, Rosa M A Moyses, Rosilene M Elias
We evaluated the effect of hydrochlorothiazide in a sample of anuric patients on hemodialysis and found an increase in serum calcium, which occurred only in those with parathyroid hormone >300 pg/ml. This finding highlights the extra-renal effect of this diuretic and a possible role of parathyroid hormone in the mechanism. PURPOSE: Thiazide diuretics are commonly used in patients with chronic kidney disease to treat hypertension. Their effects on calcium and bone metabolism are not well established, once calciuria may not fully explain levels of calcium and parathyroid hormone (PTH) in this population...
December 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/28342346/can-wastewater-based-epidemiology-be-used-to-evaluate-the-health-impact-of-temperature-an-exploratory-study-in-an-australian-population
#13
Dung Phung, Jochen Mueller, Foon Yin Lai, Jake O'Brien, Nhung Dang, Lidia Morawska, Phong K Thai
Ambient temperature is known to have impact on population health but assessing its impact by the traditional cohort approach is resource intensive. Wastewater-based epidemiology (WBE) could be an alternative for the traditional approach. This study was to provide the first evaluation to see if WBE can be used to assess the impact of temperature exposure to a population in South East Queensland, Australia using selected pharmaceuticals and personal care products (PPCPs) as biomarkers. Daily loads of eight PPCPs in wastewater collected from a wastewater treatment plant were measured from February 2011 to June 2012...
March 22, 2017: Environmental Research
https://www.readbyqxmd.com/read/28334985/multicriteria-optimization-methodology-in-stability-indicating-method-development-of-cilazapril-and-hydrochlorothiazide
#14
Jasmina Šljivic, Ana Protic, Biljana Otaševic, Jelena Golubovic, Mira Zecevic, Jovana Krmar
Multicriteria optimization methodology was applied in development of UHPLC-UV-MS method for separation of cilazapril, hydrochlorothiazide and their degradation products. This method is also applicable for analysis of cilazapril, hydrochlorothiazide and their degradation products in combined tablet formulation. Prior to method optimization forced degradation studies were conducted. Cilazapril and hydrochlorothiazide were subjected to acidic (0.1, 0.5 and 1.0 M HCl), basic (0.1, 0.5 and 1.0 M NaOH), thermal (70°C), oxidative (3-30% H2O2) degradation and photodegradation (day light)...
March 17, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28299716/fixed-dose-triple-combination-of-antihypertensive-drugs-improves-blood-pressure-control-from-clinical-trials-to-clinical-practice
#15
Alberto Mazza, Salvatore Lenti, Laura Schiavon, Antonella Paola Sacco, Fabio Dell'Avvocata, Gianluca Rigatelli, Emilio Ramazzina
INTRODUCTION: Blood pressure (BP) control is the main clinical goal in the management of hypertensive patients; however, BP in most of these patients remains uncontrolled, despite the widespread availability of antihypertensive drugs as free-combination therapy. This study compared the efficacy of a fixed-dose triple combination (FDTC) of antihypertensive drugs with that of a free combination of three antihypertensives in patients with uncontrolled hypertension. METHODS: Ninety-two patients (mean age 60...
March 15, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28291611/degradation-kinetics-of-pharmaceuticals-and-personal-care-products-in-surface-waters-photolysis-vs-biodegradation
#16
Rosa María Baena-Nogueras, Eduardo González-Mazo, Pablo A Lara-Martín
Poor removal of many pharmaceuticals and personal care products (PPCPs) in sewage treatment leads to their discharge into the receiving waters, where they may cause negative effects. Their elimination from the water column depends of several processes, including photochemical and biological degradation. We have focused this research on comparing the degradation kinetics of a wide number (n=33) of frequently detected PPCPs considering different types of water, pH and solar irradiation. For those compounds that were susceptible of photodegradation, their rates (k) varied from 0...
March 10, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28290800/-comparative-efficacy-of-the-influence-of-fixed-combinations-of-antihypertensive-drugs-that-block-the-renin-angiotensin-aldosterone-system-with-thiazide-diuretics-on-the-parameters-of-ambulatory-blood-pressure-monitoring
#17
O D Ostroumova, I A Garelik
AIM: to compare effects of fixed-dose combinations of antihypertensive drugs that block renin-angiotensin-aldosterone system (RAAS) with hydrochlorothiazide (HCT) on parameters of ambulatory blood pressure monitoring (ABPM). MATERIAL AND METHODS: Patients (n=50; 25 women, 25 men aged 40-75 years) with stage II essential hypertension who received no antihypertensive therapy for 12 weeks were randomized to receive once daily fixed-dose combinations of either valsartan/HCT (Val/HCT - group I) or quinapril/HCT (Quin/HCT - groupII) in starting doses of 80/12...
December 2016: Kardiologiia
https://www.readbyqxmd.com/read/28290783/-optimization-of-control-of-blood-pressure-metabolic-disorders-and-target-organs-protection-with-fixed-perindopril-and-indapamide-combination-in-treated-patients-with-arterial-hypertension
#18
S V Nedogoda, E V Chumachek, A A Ledyaeva, V V Tsoma, A S Salasyuk, V O Smirnova, V Ju Hripaeva, R V Palashkin
PURPOSE: to assess the potential of fixed perindopril/indapamide combination (FPIC) to improve angioprotection in patients with arterial hypertension (AP) with various efficacy of preceding therapy with combination of losartan and hydrochlorothiazide (HCTZ). MATERIAL AND METHODS: We included in this open study 50 patients with AP divided into two equal-sized groups in dependence on the achievement of target blood pressure (BP) less than 140/90 mm Hg on preceding therapy with losartan (100 mg) and HCTZ (12...
February 2017: Kardiologiia
https://www.readbyqxmd.com/read/28287295/-differential-diagnostic-dilemmas-after-use-of-an-out-of-date-antihypertensive-medication-case-report
#19
Péter Arányi, János Tomcsányi
Hydrochlorothiazide became one of the most commonly prescribed first-line antihypertensive medication, though its use is often complicated with serious side-effects. A 66-year-old female patient with a history of hypertension had suffered a transient loss of consciousness, and referred to our cardiology unit with an ST-segment elevation and giant negative T-waves in V1-2 ECG leads, long QT-segment and elevated serum creatine-kinase (5392 U/L) and troponin I (4,357 ng/ml) levels. Acute myocardial infarction was not proven (later coronarography revealed preserved coronary circulation), but severe hyponatraemia and hypokalaemia was detected, explaining a possible symptomatic seizure, and which could be accounted for a 25 mg daily hydrochlorothiazide antihypertensive treatment and - as a precipitating insult - a one-week history of gastroenteritis...
March 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28284659/diuretic-natriuretic-and-potassium-sparing-effect-of-nothofagin-isolated-from-leandra-dasytricha-a-gray-cogn-leaves-in-normotensive-and-hypertensive-rats
#20
Camila Leandra Bueno de Almeida, Thaise Boeing, Lincon Bordignon Somensi, Viviane Miranda Bispo Steimbach, Luísa Mota da Silva, Sérgio Faloni de Andrade, Franco Delle Monache, Valdir Cechinel-Filho, Priscila de Souza
Active constituents from natural origin have long been used for the treatment of patients suffering from cardiovascular and renal diseases. This study therefore aimed to investigate the diuretic and natriuretic properties of nothofagin, a dihydrochalcone isolated from Leandra dasytricha (A. Gray) Cogn. leaves in normotensive and hypertensive rats. Male Wistar normotensive rats were orally treated with vehicle (1 ml/kg); hydrochlorothiazide (HCTZ; 25 mg/kg); ethyl acetate fraction from L. dasytricha (EALD; 3-30 mg/kg) and nothofagin (NOT; 0...
April 25, 2017: Chemico-biological Interactions
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