Paola Zgouro, Orestis L Katsamenis, Thomas Moschakis, Georgios K Eleftheriadis, Athanasios S Kyriakidis, Konstantina Chachlioutaki, Paraskevi Kyriaki Monou, Marianna Ntorkou, Constantinos K Zacharis, Nikolaos Bouropoulos, Dimitrios G Fatouros, Christina Karavasili, Christos I Gioumouxouzis
Polypharmacy is a common issue, especially among elderly patients resulting in administration errors and patient inconvenience. Hypertension is a prevalent health condition that frequently leads to polypharmacy, as its treatment typically requires the co-administration of more than one different Active Pharmaceutical Ingredients (API's). To address these issues, floating hollow torus-shaped dosage forms were developed, aiming at providing prolonged gastric retention and sustained drug release. The dosage forms (polypills) containing three anti-hypertensive API's (diltiazem (DIL), propranolol (PRP) and hydrochlorothiazide (HCTZ)) were created via Fused Deposition Modelling 3D printing...
March 27, 2024: International Journal of Pharmaceutics