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hydrochlorothiazide

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https://www.readbyqxmd.com/read/29920984/first-identification-of-a-diuretic-hydrochlorothiazide-in-hair-application-to-a-doping-case-and-interpretation-of-the-results
#1
L Gheddar, J-S Raul, P Kintz
An athlete contested an adverse analytical finding involving hydrochlorothiazide, and requested our laboratory for testing his hair. As there is no reference in the literature about identification of hydrochlorothiazide in hair, several volunteers were first enrolled (four after a single 25 mg administration and ten with daily therapeutic treatment). A specific method was developed by UPLC-MS/MS. Hair samples were decontaminated with dichloromethane and 30 mg were incubated in buffer at pH 7.0 during 15 h at 50°C...
June 19, 2018: Drug Testing and Analysis
https://www.readbyqxmd.com/read/29913261/hydrochlorothiazide-use-and-risk-of-merkel-cell-carcinoma-and-malignant-adnexal-skin-tumors-a-nationwide-case-control-study
#2
Sidsel Arnspang Pedersen, Sigrun Alba Johannesdottir Schmidt, Lisbet Rosenkrantz Hölmich, Søren Friis, Anton Pottegård, David Gaist
BACKGROUND: Hydrochlorothiazide use has been associated with markedly increased risk of squamous cell carcinoma. No previous studies have investigated the association between hydrochlorothiazide use and the risk of Merkel cell carcinoma (MCC) and malignant adnexal skin tumors (MAST). OBJECTIVE: To examine the association between hydrochlorothiazide use and the risk of MCC and MAST. METHODS: Using Danish nationwide health registries, we identified all patients with incident MCC or MAST during 2004-2015 and matched cases individually to cancer-free population controls by risk set sampling...
June 15, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29907477/successful-treatment-of-normokalemic-periodic-paralysis-with-hydrochlorothiazide
#3
Yuichi Akaba, Satoru Takahashi, Yoshiaki Sasaki, Hiroki Kajino
BACKGROUND: Periodic paralysis (PP) is an autosomal dominant muscle disorder characterized by periodic muscle weakness attacks associated with serum potassium level variations. It is classified into hypokalemic (hypoKPP), hyperkalemic (hyperKPP), and normokalemic (normoKPP) forms based on the ictal serum potassium level. HyperKPP and normoKPP are caused by mutations of the same gene SCN4A, the gene encoding the skeletal muscle voltage-gated sodium channel. Prophylactic treatment with thiazide diuretics is highly effective in preventing attacks in hyperKPP...
June 12, 2018: Brain & Development
https://www.readbyqxmd.com/read/29902367/a-retrospective-study-evaluating-the-tolerability-and-effectiveness-of-adjunctive-antihypertensive-drugs-in-patients-with-inadequate-response-to-initial-treatment
#4
Rajeev Ayyagari, Jipan Xie, David Cheng, Eric Q Wu, Xing-Yue Huang, Stephanie Chen
Real-world tolerability and effectiveness of nebivolol as first add-on therapy were compared with hydrochlorothiazide, metoprolol, and amlodipine. Medical records of hypertensive adults initiating nebivolol, hydrochlorothiazide, metoprolol, or amlodipine as first add-on therapy between December 16, 2010 and July 21, 2011 were retrospectively abstracted (N = 1600; 400/treatment). Outcomes included medication-related side-effect rates and blood pressure (BP) reduction and control. Compared with nebivolol, metoprolol and amlodipine had significantly higher side-effect rates (incidence rate ratio [95% CI]: 1...
June 2018: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/29897424/challenges-in-simultaneous-determination-of-hydrochlorothiazide-and-ramipril-in-human-plasma-application-to-a-bioequivalence-study-shrhpb
#5
Bhargav Patel, Arvind G Jangid, B N Suhagia, Nirmal Desai
An isotope dilution selective and sensitive high-performance liquid chromatography-tandem mass spectrometry (LC-ESI-MS/MS) method has been developed for the simultaneous determination of hydrochlorothiazide (HCTZ) and ramipril in human plasma through a new concept of periodical polarity switching. Extraction of HCTZ, ramipril and their deuterated analogs as internal standards (ISs) was carried out from 150 μL of human plasma by solid-phase extraction method. Chromatographic separation of analytes was performed on Hypurity C18 (150 mm × 4...
June 12, 2018: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/29878020/cyanidin-3-o-glucoside-prevents-the-development-of-maladaptive-cardiac-hypertrophy-and-diastolic-heart-dysfunction-in-20-week-old-spontaneously-hypertensive-rats
#6
Basma Milad Aloud, Pema Raj, Jason McCallum, Chris Kirby, Xavier Lieben Louis, Fahmida Jahan, Liping Yu, Brett Hiebert, Todd A Duhamel, Jeffrey T Wigle, Heather Blewett, Thomas Netticadan
The present study investigated the effects of cyanidin 3-O-glucoside (C3G) in cardiomyocytes (CM) and fibroblasts exposed to endothelin 1 (ET1), as well as in the spontaneously hypertensive rat (SHR) model, alone or in combination with hydrochlorothiazide (HCT). Adult rat CM and cardiac fibroblasts (CF) were pretreated with C3G and co-incubated with ET1 (10-7 M) for 24 hours. Five-week-old male SHR and their normotensive controls, Wistar-Kyoto rats (WKY), received one of 4 treatments via oral gavage daily for 15 weeks: (1) water (control); (2) C3G (10 mg per kg per day); (3) HCT (10 mg per kg per day); (4) C3G + HCT (10 mg per kg per day each)...
June 7, 2018: Food & Function
https://www.readbyqxmd.com/read/29875965/-prevalence-and-adverse-effects-of-antihypertensive-agents-in-patients-followed-up-on-an-ambulatory-basis-at-the-university-hospital-yalgado-ou%C3%A3-draogo
#7
Georges Rosario Christian Millogo, Ragomzingba Frank Edgard Zongo, Anita Benao, Estelle Noëla Hoho Youl, Blaise Alexandre Bazona Bassoleth, Moussa Ouédraogo, Patrice Zabsonré, Innocent Pierre Guissou
Medicinal treatment of arterial hypertension (AH) may cause adverse effects which can be annoying and thus influence patient's compliance with treatment. Our study focused on these undesirable effects in patients followed up for AH on an ambulatory basis in the Department of Cardiology at the University Hospital Yalgado Ouédraogo from July to September 2015. Our aim was to determine their rates and their characteristics. Data were obtained from patients' interview, from the examination of patients' follow-up records and of medical consultation forms...
2018: Pan African Medical Journal
https://www.readbyqxmd.com/read/29813157/association-of-hydrochlorothiazide-use-and-risk-of-malignant-melanoma
#8
Anton Pottegård, Sidsel Arnspang Pedersen, Sigrun Alba Johannesdottir Schmidt, Lisbet Rosenkrantz Hölmich, Søren Friis, David Gaist
No abstract text is available yet for this article.
May 29, 2018: JAMA Internal Medicine
https://www.readbyqxmd.com/read/29805801/hypertension-treatment-in-patients-with-metabolic-syndrome-and-or-type-2-diabetes-mellitus-analysis-of-the-therapy-effectivity-and-the-therapeutic-inertia-in-outpatient-study
#9
Štefan Farský, Andrea Strišková, Marián Borčin
We have analysed the database of 1,595 consecutive patients visiting our department of cardiology and internal medicine clinic in 2005-2014. The analysis included 13,990 visit records, and the average number of visits per patient was 8.5 ± 7.0. Our goals were to evaluate the effectivity of hypertension treatment as for drug choice, decrease of sBP and dBP associated with a certain drug, a drug combination, and therapeutic inertia in patients with metabolic syndrome and/or diabetes mellitus. The final number of patients for analysis who fulfilled the inclusion criteria for interpenetration of both diagnostic circles was 570...
2018: Cardiology Research and Practice
https://www.readbyqxmd.com/read/29800784/rationale-and-design-of-the-comparison-of-3-combination-therapies-in-lowering-blood-pressure-in-black-africans-creole-study-2-%C3%A3-3-factorial-randomized-single-blind-multicenter-trial
#10
Dike B Ojji, Neil Poulter, Albertino Damasceno, Karen Sliwa, Wynand Smythe, Nicky Kramer, Motasim Badri, Veronica Francis, Akinyemi Aje, Felix Barasa, Anastase Dzudie, Erika Jones, Shehu S Kana, Pindile Mntla, Charles Mondo, Okechukwu Ogah, Elijah N Ogola, Gboyega Ogunbanjo, Ikechi Okpechi, Gabriel Shedul, Mahmoud U Sani, Grace Shedul, Bongani M Mayosi
BACKGROUND: Current hypertension guidelines recommend the use of combination therapy as first-line treatment or early in the management of hypertensive patients. Although there are many possible combinations of blood pressure(BP)-lowering therapies, the best combination for the black population is still a subject of debate because no large randomized controlled trials have been conducted in this group to compare the efficacy of different combination therapies to address this issue. METHODS: The comparison of 3 combination therapies in lowering BP in the black Africans (CREOLE) study is a randomized single-blind trial that will compare the efficacy of amlodipine plus hydrochlorothiazide versus amlodipine plus perindopril and versus perindopril plus hydrochlorothiazide in blacks residing in sub-Saharan Africa (SSA)...
April 6, 2018: American Heart Journal
https://www.readbyqxmd.com/read/29789122/indexed-plasma-drug-concentrations-for-drug-adherence-screening-in-hypertensive-patients
#11
F A Sandbaumhüter, M Haschke, B Vogt, J M Bohlender
AIM: Due to its high sensitivity, qualitative plasma drug screening by liquid chromatography/tandem mass spectrometry may not be able to distinguish same-day drug intake from drug use on preceding days and cause misclassifications of drug adherence in hypertensive patients. Analysis of plasma drug concentrations may provide more accurate results. PATIENTS AND METHODS: We describe dose-dependent indexing of plasma drug concentrations for expected peak concentrations to define individual screening thresholds for same-day drug use...
May 19, 2018: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/29783197/quantification-of-21-antihypertensive-drugs-in-serum-using-uhplc-ms-ms
#12
Per Ole M Gundersen, Arne Helland, Olav Spigset, Solfrid Hegstad
BACKGROUND: Poor drug adherence in hypertensive patients can lead to treatment failure and increased cardiovascular morbidity, as well as increased costs to society. An analytical method based on ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MSMS) was developed and validated for use in routine therapeutic drug monitoring (TDM). The method includes 21 antihypertensive drugs or active metabolites from the groups beta blockers (n=5), calcium antagonists (n=5), angiotensin II receptor antagonists (n=4), angiotensin converting enzyme (ACE) inhibitors (n=3) and diuretics (n = 3), in addition to one α1-selective alpha blocker...
April 28, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29779929/prescription-medication-use-and-antinuclear-antibodies-in-the-united-states-1999-2004
#13
Gregg E Dinse, Christine G Parks, Helen C S Meier, Caroll A Co, Edward K L Chan, Todd A Jusko, James Yeh, Frederick W Miller
BACKGROUND: Clinical reports link specific medications with the development of antinuclear antibodies (ANA), but population-based evidence is limited. OBJECTIVE: The present study investigated associations between prescription medication use and ANA in a representative sample of the adult noninstitutionalized US population, first focusing on medications previously related to ANA and then considering all medications reported in the National Health and Nutrition Examination Survey (NHANES)...
May 17, 2018: Journal of Autoimmunity
https://www.readbyqxmd.com/read/29778133/study-of-acute-kidney-injury-on-309-hypertensive-inpatients-with-acei-arb-diuretic-treatment
#14
Qiaochao Chen, Shaofang Zhu, Jianjun Liao, Wen He
BACKGROUND: The present study investigated risk factors for acute kidney injury (AKI) in patients found to be hypertensive during hospitalization who were prescribed angiotensin converting enzyme inhibitors (ACEI)/angiotensin receptor antagonists (ARB) + diuretic combinations, in order to determine which type of diuretic or combination of diuretics used in ACE/ARB-treated patients leads to a higher risk of acute kidney injury. METHOD: Data on basic information, medical history, diagnostic information and medications prescribed were obtained from the patients' medical records...
June 2018: Journal of the National Medical Association
https://www.readbyqxmd.com/read/29778098/hydrochlorothiazide-and-risk-of-hearing-disorder-a-case-series
#15
Natnael Belai, Selamawit Gebrehiwet, Yodit Fitsum, Mulugeta Russom
BACKGROUND: Hydrochlorothiazide is not known to cause hearing disorder. The Eritrean Pharmacovigilance Centre, however, has received cases of hearing disorder, including irreversible deafness, associated with hydrochlorothiazide. The aim of this study is, therefore, to assess the causal relationship between hydrochlorothiazide and hearing disorder. METHODS: Data was retrieved from the WHO global adverse drug reaction database, VigiBase™. A search on VigiBase™ was made on August 6, 2017 using "hydrochlorothiazide" as drug substance, and "ototoxicity", "decreased hearing", and "vestibular disorder" as reaction terms...
May 20, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29763692/pharmacological-evidence-that-dapi-inhibits-nhe2-in-fundulus-heteroclitus-acclimated-to-freshwater
#16
Kevin V Brix, Colin J Brauner, Dolph Schluter, Chris M Wood
Ionoregulation in the euryhaline killifish Fundulus heteroclitus has been intensively studied over the last two decades using a variety of techniques. However, there has been limited use of pharmacological inhibitors to identify proteins involved in ion transport for this species. In this study, we used a range of pharmacological inhibitors (EIPA, DAPI, ethoxzolamide, bumetanide, bafilomycin, phenamil, hydrochlorothiazide) to investigate the proteins involved in Na+ transport in freshwater (1 mM Na+ ) acclimated F...
May 12, 2018: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29753906/continuous-inkjet-printing-of-enalapril-maleate-onto-orodispersible-film-formulations
#17
Yasmin Thabet, Dominique Lunter, Joerg Breitkreutz
Piezoelectric inkjet printing onto orodispersible films (ODFs) was proven to be a successful technique applying flexible doses of active pharmaceutical ingredients (APIs) onto edible substrates. The reported API printing and ODF production was conducted in a non-continuous production approach. Within this study, drug-free and hydrochlorothiazide (HCT) containing ODFs should be imprinted in-line with enalapril maleate (EM) ink during continuous ODF production. Macrogol inks based on various solvents and solvent-water mixtures were developed providing dynamic viscosities from 7 to 17 mPa∗s...
May 10, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29748913/efficacy-and-tolerability-of-fixed-dose-combination-perindopril-indapamide-in-hypertensive-patients-with-a-history-of-stroke-or-transient-ischemic-attack-picasso-trial
#18
Csaba András Dézsi, Csaba Farsang
INTRODUCTION: In everyday medical practice, physicians often need to manage patients whose blood pressure is not well controlled. Those with a history of cerebrovascular disease are a high-risk group in need of rapid blood pressure control. METHODS: The PICASSO study was a real-life, observational trial involving 9257 inadequately treated hypertensive patients who were switched from previous therapy to the fixed-dose combination of perindopril 10 mg/indapamide 2...
May 10, 2018: Advances in Therapy
https://www.readbyqxmd.com/read/29730176/a-comparative-study-between-hot-melt-extrusion-and-spray-drying-for-the-manufacture-of-anti-hypertension-compatible-monolithic-fixed-dose-combination-products
#19
J F Kelleher, G C Gilvary, A M Madi, D S Jones, S Li, Y Tian, A Almajaan, Z Senta-Loys, G P Andrews, A M Healy
The purpose of this work was to investigate the application of different advanced continuous processing techniques (hot melt extrusion and spray drying) to the production of fixed-dose combination (FDC) monolithic systems comprising of hydrochlorothiazide and ramipril for the treatment of hypertension. Identical FDC formulations were manufactured by the two different methods and were characterised using powder x-ray diffraction (PXRD) and modulated differential scanning calorimetry (mDSC). Drug dissolution rates were investigated using a Wood's apparatus, while physical stability was assessed on storage under controlled temperature and humidity conditions...
May 3, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29676941/pk-pd-evaluation-of-fimasartan-for-the-treatment-of-hypertension-current-evidences-and-future-perspectives
#20
REVIEW
Fabio Angeli, Paolo Verdecchia, Monica Trapasso, Marina Pane, Sara Signorotti, Gianpaolo Reboldi
Fimasartan is the ninth and latest Angiotensin Receptor Blockers for the treatment of hypertension. Fimasartan is a derivative of losartan in which the imidazole ring has been replaced. It provides a selective type 1 angiotensin II receptor antagonist effect with noncompetitive, in surmountable binding. Fimasartan is rapidly absorbed following oral administration with an oral bioavailability of 18.6 ± 7.2%. Fimasartan is relatively stable in terms of metabolism and more than 90% of circulating fimasartan moieties in the plasma are in the parent form; fecal elimination and biliary excretion are the predominant elimination pathways of fimasartan...
May 2018: Expert Opinion on Drug Metabolism & Toxicology
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