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https://www.readbyqxmd.com/read/28936268/mildly-elevated-serum-total-bilirubin-is-negatively-associated-with-hemoglobin-a1c-independently-of-confounding-factors-among-community-dwelling-middle-aged-and-elderly-persons
#1
Ryuichi Kawamoto, Daisuke Ninomiya, Kensuke Senzaki, Teru Kumagi
Abnormally high glycated hemoglobin (Hb) (HbA1c) is significantly associated with oxidative stress and an increased risk of cardiovascular disease (CVD). Serum total bilirubin (T-B) may have a beneficial role in preventing oxidative changes and be a negative risk factor of CVD. Limited information is available on whether serum T-B is an independent confounding factor of HbA1c. The study subjects were 633 men aged 70 ± 9 (mean ± standard deviation (SD)) years and 878 women aged 70 ± 8 years who were enrolled consecutively from among patients aged ≥40 years through a community-based annual check-up process...
January 2017: J Circ Biomark
https://www.readbyqxmd.com/read/28935388/%C3%AE-cell-function-over-time-in-adolescents-with-new-type-2-diabetes-and-obese-adolescents-without-diabetes
#2
Deborah A Elder, Lindsey N Hornung, Jane C Khoury, David A D'Alessio
PURPOSE: The progression of β-cell function in newly diagnosed adolescents with type 2 diabetes mellitus (T2DM) is not well documented. We hypothesized that at the time of diagnosis with T2DM, adolescents would have impaired β-cell function as demonstrated by the disposition index (calculated as: insulin secretion adjusted for insulin sensitivity), and this would be followed by a rapid decline of function despite standard medical management. METHODS: Thirty-nine adolescents with recently diagnosed T2DM and 32 obese adolescent controls with normal glucose tolerance had acute insulin response to glucose, homeostatic model assessment of insulin resistance, and disposition index measured serially over 2 years...
September 18, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28934974/blood-hemoglobin-a1c-levels-and-amyotrophic-lateral-sclerosis-survival
#3
Qian-Qian Wei, Yongping Chen, Bei Cao, Ru Wei Ou, Lingyu Zhang, Yanbing Hou, Xiang Gao, Huifang Shang
BACKGROUND: There are inconsistences regarding the correlation between diabetes or fasting blood glucose concentrations and the risk and survival of amyotrophic lateral sclerosis (ALS) in the previous studies. Moreover, the association between hemoglobin A1c (HbA1c) levels, which reflect long-term glycemic status, and ALS survival was not examined. METHODS: A prospective cohort study including 450 Chinese sporadic ALS patients (254 men and 196 women; mean age: 55...
September 21, 2017: Molecular Neurodegeneration
https://www.readbyqxmd.com/read/28930832/early-central-and-peripheral-corneal-microstructural-changes-in-type-2-diabetes-mellitus-patients-identified-using-in-vivo-confocal-microscopy-a-case-control-study
#4
Jing-Hao Qu, Lei Tian, Xiao-Yu Zhang, Xu-Guang Sun
The aim of this study was to find early central and peripheral corneal microstructural changes in healthy subjects and type 2 diabetes mellitus (T2DM) patients with/without cornea fluorescein dot staining.This is a prospective case-control study of T2DM patients with/without cornea fluorescein dot staining. Age, sex, duration of diabetes, and serum glycosylated hemoglobin A1c (HbA1c) levels were recorded. Keratograph 5 M (K5 M) and in vivo confocal microscopy were performed on all subjects. The cornea was divided into 5 zones: central, superior, temporal, nasal, and inferior...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28930746/early-assessment-of-the-risk-factors-for-diabetic-retinopathy-can-reduce-the-risk-of-peripheral-arterial-and-cardiovascular-diseases-in-type-2-diabetes
#5
Juan Tang, Tao Li, Pinhong Li, Yuefei Ma, Momo Liu, Qiaoyun Shan, Fengqi Guo, Ting Zhou, Qianping Wei
BACKGROUNDS: There is still a lack of consensus about how to assess the risk of peripheral arterial disease (PAD) and cardiovascular disease (CVD) in patients with diabetic retinopathy (DR). AIMS: We investigated the risk factors for DR and their association with PAD and CVD in patients with type 2 diabetes (T2D). METHODS: A total of 1,421 patients diagnosed with T2D participated in this study. DR stages were classified as non-DR, nonproliferative DR (NPDR), or proliferative DR (PDR)...
September 21, 2017: Ophthalmic Research
https://www.readbyqxmd.com/read/28930495/a-multicenter-real-life-study-on-the-effect-of-flash-glucose-monitoring-on-glycemic-control-in-patients-with-type-1-and-type-2-diabetes
#6
Ranjit Mohan Anjana, Jothydev Kesavadev, Deshpande Neeta, Mangesh Tiwaskar, Rajendra Pradeepa, Saravanan Jebarani, Suresh Thangamani, Nadiminty Ganapathi Sastry, Srivastava Brijendra Kumar, Muthu Ramu, Pokal Prasanna Kumar Gupta, Jayaprakash Vignesh, Sundramoorthy Chandru, Sengottuvel Kayalvizhi, Padoor Sethuraman Jagdish, Subash Chandra Bose Uthra, Munawar Lovelena, Sah Jyoti, Sengodan Suguna Priya, Alagarsamy Kannan, Viswanathan Mohan, Ranjit Unnikrishnan
AIM: To assess the efficacy of ambulatory glucose profiling (AGP) generated by FreeStyle LibrePro(™) flash glucose monitoring (FCGM) on glycemic control in patients with uncontrolled type 1 diabetes (T1D) and type 2 diabetes (T2D). METHODS: Clinical and biochemical data were obtained from 5072 patients with diabetes who had an A1c ≥7% (2536 who had been initiated on FCGM-based AGP between March 2015 and October 2016 [cases] and 2536 age-, gender-, A1c-, site- and time-matched controls who were not initiated on AGP) across seven diabetes clinics in India...
September 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/28926868/polycystic-ovary-syndrome-pcos-in-juvenile-and-adult-type-1-diabetes-in-a-german-austrian-cohort
#7
Christina Reinauer, Esther Bollow, Elke Fröhlich-Reiterer, Katharina Laubner, Dominik Bergis, Christof Schöfl, Hans-Peter Kempe, Michael Hummel, Pia Hennes, Katja Gollisch, Holger Haberland, Nicolin Datz, Thomas Meissner, Reinhard W Holl
Context While an association between PCOS and type 2 diabetes is well established, to date there have been few data on clinical care of type 1 diabetes (T1D) patients with PCOS. Objective The aim of our study was to characterize T1D patients with the comorbidity of PCOS within the DPV cohort with regard to diabetes phenotype, therapy and metabolic control. Design and Setting Clinical data from the prospective German/Austrian DPV cohort on patients with T1D and documented PCOS (n=76) were compared to female T1D controls (n=32,566) in reproductive age...
September 19, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28926628/application-of-raman-spectroscopy-in-type-2-diabetes-screening-in-blood-using-leucine-and-isoleucine-amino-acids-as-biomarkers-and-in-comparative-anti-diabetic-drugs-efficacy-studies
#8
Zephania Birech, Peter Waweru Mwangi, Fredrick Bukachi, Keith Makori Mandela
Diabetes is an irreversible condition characterized by elevated blood glucose levels. Currently, there are no predictive biomarkers for this disease and the existing ones such as hemoglobin A1c and fasting blood glucose are used only when diabetes symptoms are noticed. The objective of this work was first to explore the potential of leucine and isoleucine amino acids as diabetes type 2 biomarkers using their Raman spectroscopic signatures. Secondly, we wanted to explore whether Raman spectroscopy can be applied in comparative efficacy studies between commercially available anti-diabetic drug pioglitazone and the locally used anti-diabetic herbal extract Momordica spinosa (Gilg...
2017: PloS One
https://www.readbyqxmd.com/read/28923815/use-of-complementary-health-approaches-among-diverse-primary-care-patients-with-type-2-diabetes-and-association-with-cardiometabolic-outcomes-from-the-sf-bay-collaborative-research-network-sf-bay-crn
#9
Margaret A Handley, Judy Quan, Maria T Chao, Neda Ratanawongsa, Urmimala Sarkar, Sophia Emmons-Bell, Dean Schillinger
PURPOSE: To describe use of complementary health approaches (CHAs) among patients with type 2 diabetes, and independent associations between CHA use and Hemoglobin A1c (A1C) and lower-density lipoprotein (LDL) cholesterol. METHODS: Participants were enrolled onto the SMARTSteps Program, a diabetes self-management support program conducted between 2009 and 2013 in San Francisco. At the 6-month interview, CHA use in the prior 30 days was estimated using a 12-item validated instrument...
September 2017: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/28923701/average-glucose-from-hemoglobin-a1c-for-altered-red-blood-cell-lifetimes-predictions-based-on-a-model-for-hemoglobin-a1c-formation
#10
Ross Molinaro, Jay H Herman, Douglas F Stickle
BACKGROUND: A model for hemoglobin A1c (HbA1c) formation was used to predict the relationship between average glucose (AG) and %HbA1c under conditions of altered red blood cell lifetime (RCL). METHODS: Using a kinetic mass balance model for formation of HbA1c in red blood cells as a function of age (time in circulation), whole blood %HbA1c vs. glucose was calculated based on the nonlinear distribution of red blood cells as a function of age across RCL. RESULTS: Model calculations provided a close fit to the standard relationship of estimated average glucose to %HbA1c for normal RCL (r>0...
September 15, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28923672/relationship-between-glycaemic-levels-and-arterial-stiffness-in-non-diabetic-adults
#11
Iván Cavero-Redondo, Vicente Martínez-Vizcaíno, Celia Álvarez-Bueno, José Ignacio Recio-Rodríguez, Manuel Ángel Gómez-Marcos, Luis García-Ortiz
OBJECTIVE: To examine, in a non-diabetic population, whether the association between arterial stiffness and glycaemic levels depends on the test used as a glycaemic indicator, fasting plasma glucose (FPG) or glycated haemoglobin A1c (HbA1c). PATIENT POPULATION AND METHODS: A cross-sectional analysis of a 220 non-diabetic subsample from the EVIDENT II study in which FPG, HbA1c and arterial stiffness-related parameters (pulse wave velocity, radial and central augmentation index, and central pulse pressure) were determined...
September 15, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28922296/trajectories-of-glycemic-change-in-a-national-cohort-of-adults-with-previously-controlled-type-2-diabetes
#12
Rozalina G McCoy, Che Ngufor, Holly K Van Houten, Brian Caffo, Nilay D Shah
BACKGROUND: Individualized diabetes management would benefit from prospectively identifying well-controlled patients at risk of losing glycemic control. OBJECTIVES: To identify patterns of hemoglobin A1c (HbA1c) change among patients with stable controlled diabetes. RESEARCH DESIGN: Cohort study using OptumLabs Data Warehouse, 2001-2013. We develop and apply a machine learning framework that uses a Bayesian estimation of the mixture of generalized linear mixed effect models to discover glycemic trajectories, and a random forest feature contribution method to identify patient characteristics predictive of their future glycemic trajectories...
September 15, 2017: Medical Care
https://www.readbyqxmd.com/read/28921919/oral-glucose-lowering-with-linagliptin-and-metformin-compared-with-linagliptin-alone-as-initial-treatment-in-asian-patients-with-newly-diagnosed-type-2-diabetes-and-marked-hyperglycemia-subgroup-analysis-of-a-randomized-clinical-trial
#13
Ronald Cw Ma, Stefano Del Prato, Baptist Gallwitz, Vyankatesh K Shivane, Diane Lewis-D'Agostino, Zelie Bailes, Sanjay Patel, Jisoo Lee, Maximilian von Eynatten, Maximiliano Di Domenico, Stuart A Ross
AIMS/INTRODUCTION: Type 2 diabetes mellitus (T2DM) is an epidemic in Asia, yet clinical trials of glucose-lowering therapies often enrol predominantly Western populations. We explored the initial combination of metformin and linagliptin, a dipeptidyl peptidase-4 inhibitor, in newly diagnosed T2DM patients in Asia with marked hyperglycemia. MATERIALS AND METHODS: This was a post-hoc subgroup analysis of a multinational, parallel-group clinical trial in which 316 newly diagnosed T2DM patients with glycated hemoglobin A1c (HbA1c) 8...
September 16, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28919876/peptide-composition-of-stroke-causing-emboli-correlate-with-serum-markers-of-atherosclerosis-and-inflammation
#14
Neal M Rao, Joseph Capri, Whitaker Cohn, Maram Abdaljaleel, Lucas Restrepo, Jeffrey A Gornbein, William H Yong, David S Liebeskind, Julian P Whitelegge
INTRODUCTION: The specific protein composition of stroke-causing emboli is unknown. Because ischemic stroke has a varied etiology, it is possible that the composition of the thrombus from which an embolus originated will have distinctive molecular characteristics reflective of the underlying pathophysiology. We used mass spectrometry to evaluate the protein composition of retrieved emboli from patients with differing stroke etiologies and correlated the protein levels to serum predictors of atherosclerosis...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28919426/improving-glycemic-control-in-model-mice-with-type-2-diabetes-by-increasing-superoxide-dismutase-sod-activity-using-silk-fibroin-hydrolysate-sfh
#15
Harry Jung, Yoo Yeon Kim, Boyoung Kim, Hajin Nam, Jun Gyo Suh
Islet cell dysfunction in type 2 diabetes is primarily attributed to the increased apoptosis of pancreatic beta cells. Silk fibroin hydrolysate (SFH) has an effect on blood in type 2 diabetes model mice (C57BL/KsJ-db/db). However, its exact mechanism is unknown. The type 2 diabetes model mice were randomly divided into non-diabetic mice (ND), diabetic mice (DB), and diabetic mice treated with silk fibroin hydrolysate (DB-SFH). The results showed that SFH significantly decreased fasting blood glucose and hemoglobin A1c (HbA1c)...
September 15, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28916437/sex-specific-99th-percentiles-derived-from-the-aacc-universal-sample-bank-for-the-roche-gen-5-ctnt-assay-comorbidities-and-statistical-methods-influence-derivation-of-reference-limits
#16
Ian L Gunsolus, Allan S Jaffe, Anne Sexter, Karen Schulz, Ranka Ler, Brittany Lindgren, Amy K Saenger, Sara A Love, Fred S Apple
OBJECTIVES: Our purpose was to determine a) overall and sex-specific 99th percentile upper reference limits (URL) and b) influences of statistical methods and comorbidities on the URLs. METHODS: Heparin plasma from 838 normal subjects (423 men, 415 women) were obtained from the AACC (Universal Sample Bank). The cobas e602 measured cTnT (Roche Gen 5 assay); limit of detection (LoD), 3ng/L. Hemoglobin A1c (URL 6.5%), NT-proBNP (URL 125ng/L) and eGFR (60mL/min/1.73m(2)) were measured, along with identification of statin use, to better define normality...
September 13, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28912054/effectiveness-of-pharmacist-interventions-on-cardiovascular-risk-in-patients-with-ckd-a-subgroup-analysis-of-the-randomized-controlled-rxeach-trial
#17
Yazid N Al Hamarneh, Ross T Tsuyuki, Charlotte A Jones, Braden Manns, Marcello Tonelli, Nairne Scott-Douglass, Kailash Jindal, Wendy Tink, Brenda R Hemmelgarn
BACKGROUND: Affecting a substantial proportion of adults, chronic kidney disease (CKD) is considered a major risk factor for cardiovascular (CV) events. It has been reported that patients with CKD are underserved when it comes to CV risk reduction efforts. STUDY DESIGN: Prespecified subgroup analysis of a randomized controlled trial. SETTING & PARTICIPANTS: Adults with CKD and at least 1 uncontrolled CV risk factor were enrolled from 56 pharmacies across Alberta, Canada...
September 11, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/28905044/is-there-a-relationship-between-blood-lipids-and-lumbar-disc-herniation-in-young-turkish-adults
#18
Nese Keser, Erhan Celikoglu, Merih İs, Zeynep Demet İlgezdi, Bendigar Sunar, Yusuf Sinan Aydin, Ahmet Ugur Kevenk, Bora Gurer, Ali Fatih Ramazanoglu, Nurgul Keser
INTRODUCTION: Atherosclerosis might diminish the nutrient supply to intervertebral discs (IVD), leading to disc herniation. Therefore, there is interest in determining the possible association between the blood lipid profile and lumbar disc herniation (LDH). We aimed to evaluate the association between blood lipids and LDH in a homogeneous group of patients, controlling for age- and sex-specific effects. MATERIAL AND METHODS: This is a case-control study which consisted of 100 individuals (mean age: 41...
2017: Arch Med Sci Atheroscler Dis
https://www.readbyqxmd.com/read/28903724/resting-heart-rate-and-impaired-glucose-regulation-in-middle-aged-and-elderly-chinese-people-a-cross-sectional-analysis
#19
Zhen Yang, Weiwei Zhang, Lingfei Zhu, Ning Lin, Yixin Niu, Xiaoyong Li, Shuai Lu, Hongmei Zhang, Xuanchun Wang, Jie Wen, Guang Ning, Li Qin, Qing Su
BACKGROUND: Elevated resting heart rate (RHR) has been reported to be associated with metabolic syndrome and type 2 diabetes. The aim of this study was to explore whether a positive relationship exists between RHR and impaired glucose regulation (IGR) among middle-aged and older Chinese individuals. METHODS: We conducted a cross-sectional analysis that included a total of 9898 subjects (3194 men and 6704 women) in a Chinese population. The RHRs were derived from ECG recordings, and the subjects were stratified based on RHR quartiles...
September 13, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28902790/impact-of-treatments-on-diabetic-control-and-gastrointestinal-symptoms-after-total-pancreatectomy
#20
Maarten R Struyvenberg, Zhi Ven Fong, Camilia R Martin, Jennifer F Tseng, Thomas E Clancy, Carlos Fernández-Del Castillo, Hanna J Tillman, Melena D Bellin, Steven D Freedman
OBJECTIVES: The aims of this study were to compare the safety, efficacy, and patients' quality of life with continuous subcutaneous insulin infusion (CSII) versus multiple daily injections (MDIs) in type 3c diabetes mellitus (T3cDM) following total pancreatectomy (TP) and pancreatic enzyme usage. METHODS: Thirty-nine patients with T3cDM (18 CSII patients vs 21 MDI patients) who underwent TP between 2000 and 2016 at 3 Harvard-affiliated hospitals and the University of Minnesota returned prospectively obtained questionnaires examining quality of life and both endocrine and exocrine pancreatic functions...
October 2017: Pancreas
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