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https://www.readbyqxmd.com/read/28938619/anti-cancer-efficacy-of-biotinylated-chitosan-nanoparticles-in-liver-cancer
#1
Mingrong Cheng, Weiping Zhu, Qing Li, Dejian Dai, Yiming Hou
The present study investigated the synthesis of biotinylated chitosan (Bio-CS) from chitosan using a nanomaterial skeleton with biotin and the successful targeting of the formulation in liver cancer cells. Bio-CS was validated by fourier transformed infrared spectroscopy and hydrogen(-1) nuclear magnetic resonance spectroscopy. Bio-CS and plasmid DNA were used to construct Bio-CS/plasmid DNA nanoparticles according to the optimal molar ratio of 1:1 and the optimal pH-value of 5.5. Under these conditions, the parameters mean particle size, potential, encapsulation rate and drug loading, were 82...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938612/magnetic-resonance-imaging-tracking-and-assessing-repair-function-of-the-bone-marrow-mesenchymal-stem-cells-transplantation-in-a-rat-model-of-spinal-cord-injury
#2
Hongwu Zhang, Liqin Wang, Shihong Wen, Qingfeng Xiang, Xianhong Xiang, Caixia Xu, Yong Wan, Jingnan Wang, Bin Li, Yiqian Wan, Zhiyun Yang, David Y B Deng
The transplantation of bone marrow mesenchymal stem cells (BMSCs) to repair spinal cord injury (SCI) has become a promising therapy. However, there is still a lack of visual evidence directly implicating the transplanted cells as the source of the improvement of spinal cord function. In this study, BMSCs were labeled with NF-200 promoter and lipase-activated gadolinium-containing nanoparticles (Gd-DTPA-FA). Double labeled BMSCs were implanted into spinal cord transaction injury in rat models in situ, the function recovery was evaluated on 1st, 7th, 14th, 28 th days by MRI, Diffusion Tensor Imaing, CT imaging and post-processing, and histological observations...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938402/the-pathophysiological-sequence-of-glucocorticoid-induced-osteonecrosis-of-the-femoral-head-in-male-mice
#3
Robert S Weinstein, Erin A Hogan, Michael J Borrelli, Serguei Liachenko, Charles A O'Brien, Stavros C Manolagas
In search of the sequence of pathogenic events leading to glucocorticoid-induced osteonecrosis, we determined the molecular, biomechanical, cellular, and vascular changes in the femur of C57BL/6 mice receiving prednisolone for 14, 28 or 42 days. The femoral head, but not the distal femur, of mice treated for 14 days showed a decrease in the expression of the hypoxia-inducible factor (Hif-1α) and vascular endothelial growth factor (VEGF), the number of osteoblasts, bone formation rate and strength and an increase in osteoclasts...
September 14, 2017: Endocrinology
https://www.readbyqxmd.com/read/28938357/comments-regarding-high-resolution-magnetic-resonance-imaging-of-aging-upper-face-fat-compartments
#4
Kun Hwang
No abstract text is available yet for this article.
September 16, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28938330/temporal-scalp-thickness-body-mass-index-and-suprafascial-placement-of-receiver-coil-of-the-cochlear-implant
#5
Orhan Ozturan, Alper Yenigun, Erol Senturk, Omer Faruk Calim, Fadlullah Aksoy, Sabri Baki Eren
OBJECTIVE: The objectives of this study are to demonstrate the relationship between the thickness of the temporal scalp and body mass index (BMI), age, and sex, and to present the surgical technique which we perform in patients with a thick scalp. MATERIALS AND METHODS: This is a retrospective, cross-sectional study. This study was performed in a tertiary referral center. Cranial computed tomography images of 469 subjects were included in the study. These subjects were evaluated according to BMI, age, and sex...
September 21, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28938324/bilateral-subperiosteal-hematoma-and-orbital-compression-syndrome-in-sickle-cell-disease
#6
Cem Sundu, Erdem Dinç, Ayça Sari, Selma Ünal, Özer Dursun
A 14-year-old boy with sickle cell disease presented with preseptal cellulitis findings as proptosis, eyelid edema, and hyperemia. His best corrected visual acuity in the right eye was 20/20 and 16/20 in the left eye. He had limited ductions in vertical and lateral gazes in both eyes. Bilateral venous tortuosity was observed in posterior segment examination. Orbital bone infarction and subperiosteal hematoma were seen in magnetic resonance imaging. He was diagnosed as having orbital compression syndrome secondary to vaso-occlusive crisis of sickle cell disease and was treated with intravenous ampicilin-sulbactam and methylprednisolone...
September 21, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28938276/anesthesia-with-dexmedetomidine-and-low-dose-isoflurane-increases-solute-transport-via-the-glymphatic-pathway-in-rat-brain-when-compared-with-high-dose-isoflurane
#7
Helene Benveniste, Hedok Lee, Fengfei Ding, Qian Sun, Ehab Al-Bizri, Rany Makaryus, Stephen Probst, Maiken Nedergaard, Elliot A Stein, Hanbing Lu
BACKGROUND: The glymphatic pathway transports cerebrospinal fluid through the brain, thereby facilitating waste removal. A unique aspect of this pathway is that its function depends on the state of consciousness of the brain and is associated with norepinephrine activity. A current view is that all anesthetics will increase glymphatic transport by inducing unconsciousness. This view implies that the effect of anesthetics on glymphatic transport should be independent of their mechanism of action, as long as they induce unconsciousness...
September 22, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28938274/pain-free-3-t-mri-scans-in-cochlear-implantees
#8
Ingo Todt, Anja Tittel, Arne Ernst, Philipp Mittmann, Sven Mutze
OBJECTIVE: For cochlear implant recipients, undergoing magnetic resonance imaging (MRI) scans is associated with safety risks and potential side effects. Even following safety guidelines, potential complications (e.g., pain, magnet dislocation, image artifacts) are possible during 1.5 Tesla (T) MRI scans. The stronger static magnetic field of a 3.0 T scanner is associated with further risks of complication, including implant demagnetization. These complications led to the recent development of rotatable internal receiver magnets with a diametrical magnetization...
September 21, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28938219/age-dependent-effects-of-acute-methylphenidate-on-amygdala-reactivity-in-stimulant-treatment-naive-patients-with-attention-deficit-hyperactivity-disorder
#9
Marco A Bottelier, Anouk Schrantee, Bart Ferguson, Hyke G H Tamminga, Cheima Bouziane, J J Sandra Kooij, Michiel B de Ruiter, Liesbeth Reneman
In the present study, we investigate whether methylphenidate (MPH) affects emotional processing and whether this effect is modulated by age. We measured amygdala reactivity with functional Magnetic Resonance Imaging (fMRI) during processing of angry and fearful facial expressions in male stimulant treatment-naive patients with ADHD (N = 35 boys; N = 46 men) and 23 healthy control subjects (N = 11 boys; N = 12 men). In ADHD patients, we also measured amygdala reactivity 90min after an acute oral challenge with MPH (0...
September 12, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28938143/contribution-of-transcranial-magnetic-stimulation-to-assessment-of-brain-connectivity-and-networks
#10
REVIEW
Mark Hallett, Riccardo Di Iorio, Paolo Maria Rossini, Jung E Park, Robert Chen, Pablo Celnik, Antonio P Strafella, Hideyuki Matsumoto, Yoshikazu Ugawa
The goal of this review is to show how transcranial magnetic stimulation (TMS) techniques can make a contribution to the study of brain networks. Brain networks are fundamental in understanding how the brain operates. Effects on remote areas can be directly observed or identified after a period of stimulation, and each section of this review will discuss one method. EEG analyzed following TMS is called TMS-evoked potentials (TEPs). A conditioning TMS can influence the effect of a test TMS given over the motor cortex...
September 5, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28938140/encapsulating-fe3o4-into-calcium-alginate-coated-chitosan-hydrochloride-hydrogel-beads-for-removal-of-cu-ii-and-u-vi-from-aqueous-solutions
#11
Xiaofeng Yi, Jiarui He, Yingyuan Guo, Zhenhua Han, Meixia Yang, Jiali Jin, Junjie Gu, Minrui Ou, Xiaoping Xu
The aim of this work was to study the removal of Cu (II) and U (VI) ions from aqueous solutions by encapsulating magnetic Fe3O4 nanoparticles into calcium alginate coated chitosan hydrochloride (CCM) hydrogel beads. ATR-FTIR and XRD analysis data indicated that the CCM composites were successfully prepared. SEM images and EDX spectra showed that Cu(2+) and UO2(2+) ions were adhered onto sorbents. Adsorption properties for removal of both copper and uranium ions under various experimental conditions were investigated...
September 19, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28938003/oxsa-an-open-source-magnetic-resonance-spectroscopy-analysis-toolbox-in-matlab
#12
Lucian A B Purvis, William T Clarke, Luca Biasiolli, Ladislav Valkovič, Matthew D Robson, Christopher T Rodgers
In vivo magnetic resonance spectroscopy provides insight into metabolism in the human body. New acquisition protocols are often proposed to improve the quality or efficiency of data collection. Processing pipelines must also be developed to use these data optimally. Current fitting software is either targeted at general spectroscopy fitting, or for specific protocols. We therefore introduce the MATLAB-based OXford Spectroscopy Analysis (OXSA) toolbox to allow researchers to rapidly develop their own customised processing pipelines...
2017: PloS One
https://www.readbyqxmd.com/read/28937853/assessment-of-microvascular-invasion-of-hepatocellular-carcinoma-with-diffusion-kurtosis-imaging
#13
Wen-Tao Wang, Li Yang, Zhao-Xia Yang, Xin-Xing Hu, Ying Ding, Xu Yan, Cai-Xia Fu, Robert Grimm, Meng-Su Zeng, Sheng-Xiang Rao
Purpose To evaluate the potential role of diffusion kurtosis imaging and conventional magnetic resonance (MR) imaging findings including standard monoexponential model of diffusion-weighted imaging and morphologic features for preoperative prediction of microvascular invasion (MVI) of hepatocellular carcinoma (HCC). Materials and Methods Institutional review board approval and written informed consent were obtained. Between September 2015 and November 2016, 84 patients (median age, 54 years; range, 29-79 years) with 92 histopathologically confirmed HCCs (40 MVI-positive lesions and 52 MVI-negative lesions) were analyzed...
September 22, 2017: Radiology
https://www.readbyqxmd.com/read/28937575/committee-opinion-no-723-guidelines-for-diagnostic-imaging-during-pregnancy-and-lactation
#14
(no author information available yet)
Imaging studies are important adjuncts in the diagnostic evaluation of acute and chronic conditions. However, confusion about the safety of these modalities for pregnant and lactating women and their infants often results in unnecessary avoidance of useful diagnostic tests or the unnecessary interruption of breastfeeding. Ultrasonography and magnetic resonance imaging are not associated with risk and are the imaging techniques of choice for the pregnant patient, but they should be used prudently and only when use is expected to answer a relevant clinical question or otherwise provide medical benefit to the patient...
October 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28937570/committee-opinion-no-723-summary-guidelines-for-diagnostic-imaging-during-pregnancy-and-lactation
#15
(no author information available yet)
Imaging studies are important adjuncts in the diagnostic evaluation of acute and chronic conditions. However, confusion about the safety of these modalities for pregnant and lactating women and their infants often results in unnecessary avoidance of useful diagnostic tests or the unnecessary interruption of breastfeeding. Ultrasonography and magnetic resonance imaging are not associated with risk and are the imaging techniques of choice for the pregnant patient, but they should be used prudently and only when use is expected to answer a relevant clinical question or otherwise provide medical benefit to the patient...
October 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28937545/non-contrast-pseudo-continuous-arterial-spin-labeling-and-accelerated-3-dimensional-radial-acquisition-intracranial-3-dimensional-magnetic-resonance-angiography-for-the-detection-and-classification-of-intracranial-arteriovenous-shunts
#16
Tilman Schubert, Zachary Clark, Carolina Sandoval-Garcia, Ryan Zea, Oliver Wieben, Huimin Wu, Patrick A Turski, Kevin M Johnson
OBJECTIVES: The aim of this study was to assess the sensitivity and specificity of pseudo-continuous arterial spin labeling (PCASL) magnetic resonance angiography (MRA) with 3-dimensional (3D) radial acquisition for the detection of intracranial arteriovenous (AV) shunts. MATERIALS AND METHODS: A total of 32 patients who underwent PCASL-MRA, clinical magnetic resonance imaging (MRI)/MRA exam, and digital subtraction angiography (DSA) were included in this retrospective analysis...
September 20, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28937492/magnetic-resonance-imaging-of-the-soft-tissue-vascular-anomalies-in-torso-and-extremities-in-children-an-update-with-2014-international-society-for-the-study-of-vascular-anomalies-classification
#17
Elizabeth Snyder, Kate Puttgen, Sally Mitchell, Shivani Ahlawat, Aylin Tekes
Vascular anomalies can occur anywhere in the body, and the majority present in the pediatric population. Accurate classification is essential for proper clinical evaluation, particularly because multidisciplinary care is often required. The International Society for the Study of Vascular Anomalies classification offers a comprehensive classification for all subspecialties. In this review article, we present a magnetic resonance imaging protocol with exemplary cases of the most common types of vascular anomalies in the pediatric trunk and extremities using the current International Society for the Study of Vascular Anomalies classification...
September 20, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28937490/the-relationship-between-body-mass-index-and-fatty-infiltration-in-the-shoulder-musculature
#18
David F Dow, Kaushal Mehta, Yuanfang Xu, Eric England
OBJECTIVE: Fatty infiltration in the rotator cuff muscles has been well studied in the setting of rotator cuff tendon tears to help predict outcomes of surgical repair. Fatty infiltration in the rotator cuff has also been independently correlated to the variables of age and sex. The purpose of our study was to determine if there is a relationship between body mass index and fatty infiltration in patients with no imaging evidence of rotator cuff tendinosis or tear. METHODS: Radiology reports of all magnetic resonance imaging examinations of the shoulder were searched over a 2-year period...
September 20, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28937488/the-significance-of-arachnoid-granulation-in-patients-with-idiopathic-intracranial-hypertension
#19
Gaurav Vishwasrao Watane, Bhumi Patel, Derek Brown, M Reza Taheri
PURPOSE: The aim of this article was to study the significance of arachnoid granulations (AGs) in patients with idiopathic intracranial hypertension (IIH). METHODS: In an institutional review board-approved retrospective chart review study, 79 patients with clinical diagnosis of idiopathic increased intracranial pressure were compared with 63 patients with a diagnosis of multiple sclerosis. Inclusion criteria also included available magnetic resonance imaging (MRI) of the brain, older than 18 years, and female sex...
September 20, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28937482/diffusion-tensor-imaging-of-lumbar-vertebras-in-female-adolescent-idiopathic-scoliosis-initial-findings
#20
Dongmei Wang, Shoufeng Wang, Yao Gao, Zhengyang Zhou, Jian He
OBJECTIVE: The purpose of this study was to characterize diffusion tensor imaging (DTI) features of lumbar vertebras in adolescent idiopathic scoliosis (AIS) patients. METHODS: Fifty-two AIS patients and 20 healthy volunteers underwent 3-T magnetic resonance scanning including DTI sequence. The fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values on the convex and concave sides of lumbar vertebras were obtained and compared. RESULTS: The FA and ADC values differed significantly between the convex and concave side of lumbar vertebras in AIS (P < 0...
September 20, 2017: Journal of Computer Assisted Tomography
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