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https://www.readbyqxmd.com/read/28803504/the-pharmacological-management-of-nafld-in-children-and-adolescents
#1
Savinda Liyanagedera, Robert Patrick Williams, Silvio Veraldi, Valerio Nobili, Jake P Mann
Non-alcoholic fatty liver disease (NAFLD) represents a spectrum, including 'simple' steatosis, non-alcoholic steatohepatitis (NASH), and fibrosis. Increasing prevalence of NAFLD has followed the international rise in obesity and lifestyle modification is the mainstay therapy for children. To date, pharmacological trials have had varying efficacy but a large number of new agents are in early phase trials for adults. Areas covered: This review explores the effect of current and potential future paediatric NAFLD treatments in terms of histological and biochemical endpoints...
August 14, 2017: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/28803396/early-regression-of-carotid-intima-media-thickness-after-bariatric-surgery-and-its-relation-to-serum-leptin-reduction
#2
G Lambert, Marcelo Miranda de Oliveira Lima, A C Felici, J C Pareja, A C J Vasques, F S Novaes, S Rodovalho, F F P Hirsch, J R Matos-Souza, Élinton A Chaim, B Geloneze
PURPOSE: Bariatric surgery (BS) promotes carotid intima-media thickness (C-IMT) regression as early as 6 months post-surgery. To verify whether C-IMT regression occurs even earlier, we aimed at the effect of Roux-en-Y gastric bypass (RYGBP) and biliopancreatic diversion (BPD) on C-IMT 1-2 months and 12 months post-surgery. SUBJECTS/METHODS: Prospective trial. BS was performed on 109 patients either with (RYGBP = 42; BDP = 40) or without type 2 diabetes (RYGBP = 27)...
August 12, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28802901/effect-of-vertical-sleeve-gastrectomy-on-alcohol-consumption-and-preferences-in-dietary-obese-rats-and-mice-a-plausible-role-for-altered-ghrelin-signaling
#3
Elise R Orellana, Catherine Jamis, Nelli Horvath, Andras Hajnal
Vertical sleeve gastrectomy (VSG) and Roux-en-Y gastric bypass (RYGB) are the most common surgical options for the treatment of obesity and metabolic disorder. Whereas RYGB may result in greater and more durable weight loss, recent clinical and pre-clinical studies in rats have raised concerns that RYGB surgery may increase risk for alcohol use disorder (AUD). In contrast, recent clinical reports suggest a lesser risk for AUD following VSG, although no preclinical studies have been done to confirm that. Therefore, the present study sought to determine the effects of VSG on ethanol intake and preferences in rodent models using protocols similar to those previously used in animal studies for RYGB...
August 9, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28802873/gut-check-on-diabesity-leveraging-gut-mechanisms-for-the-treatment-of-type-2-diabetes-and-obesity
#4
REVIEW
Sarah Will, David C Hornigold, David J Baker, Matthew P Coghlan, Malcolm Mesquita, James L Trevaskis, Jacqueline Naylor
Gut hormones have long been understood to regulate food intake and metabolism. Bariatric surgery significantly elevates circulating gut hormone levels and is proven to affect acute remission of type 2 diabetes before any weight loss is observed. Subsequent weight loss is accrued over weeks to months but is sustained into the long term. Hence, there exists great enthusiasm to recapitulate these changes in gut hormones in the form of novel combination drugs for type 2 diabetes and obesity.
August 10, 2017: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/28802792/fat-mass-fat-free-mass-and-resting-metabolic-rate-in-weight-stable-sleeve-gastrectomy-patients-compared-with-weight-stable-nonoperated-patients
#5
Luigi Schiavo, Giuseppe Scalera, Vincenzo Pilone, Gabriele De Sena, Antonio Iannelli, Alfonso Barbarisi
BACKGROUND: There is evidence that body composition and resting metabolic rate (RMR) in weight-stable patients after Roux-en-Y gastric bypass and duodenal switch is similar to that of nonoperated individuals within the same body mass index (BMI) interval. Currently, data concerning fat mass (FM), fat-free mass (FFM), and RMR on weight-stable patients after sleeve gastrectomy (SG) are lacking. OBJECTIVES: To assess FM, FFM, and RMR, in a selected and homogenous population of weight-stable SG patients (WSSG) and compare them with those obtained from healthy normal weight-stable nonoperated (WSNO) volunteers controls of similar sex, age, and BMI...
July 1, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28801703/the-long-term-effects-of-bariatric-surgery-on-type-2-diabetes-remission-microvascular-and-macrovascular-complications-and-mortality-a-systematic-review-and-meta-analysis
#6
REVIEW
Binwu Sheng, Khoa Truong, Hugh Spitler, Lu Zhang, Xuetao Tong, Liwei Chen
This systematic review aimed to evaluate the long-term (≥ 5 years) outcomes of bariatric surgery on diabetes remission, microvascular and macrovascular events, and mortality among type 2 diabetes (T2D) patients. Ten articles (one randomized controlled trial and nine cohorts) met the inclusion criteria and were included in this review. Pooled estimates of nine cohort studies showed that surgery significantly increased the diabetes remission (relative risk (RR) = 5.90; 95% CI 3.75-9.28), reduced the microvascular (RR = 0...
August 11, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28798989/perceived-postoperative-support-differentiates-responders-from-non-responders-3%C3%A2-years-after-laparoscopic-roux-en-y-gastric-bypass
#7
Ulrike B J M Ter Braak, Chris Hinnen, Marjolein M C de Jong, Arnold van de Laar
BACKGROUND: Bariatric surgery is an effective intervention for the majority of patients with morbid obesity, but a significant minority fails to achieve substantial weight loss. In the search of possible predictors of weight loss following bariatric surgery, preoperative factors turn out to have limited predictive power. This study will examine the impact of two postoperative factors on weight loss: perceived social support and stressful life events. METHODS: From the entire 2013 cohort that underwent laparoscopic Roux-and-Y gastric bypass (LRYGB) in a general hospital in the Netherlands, a group of 56 non-responders and a matched group of 56 responders were selected, using an alterable weight loss (%AWL)-based percentile chart...
August 11, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28797697/changes-in-inflammatory-endometrial-cancer-risk-biomarkers-in-individuals-undergoing-surgical-weight-loss
#8
Faina Linkov, Sharon L Goughnour, Tianzhou Ma, Zhongying Xu, Robert P Edwards, Anna E Lokshin, Ramesh C Ramanathan, Giselle G Hamad, Carol McCloskey, Dana H Bovbjerg
OBJECTIVE: Obesity has been strongly linked to endometrial cancer (EC) risk. A number of potential EC risk biomarkers have been proposed, including heightened pro-inflammatory cytokines and adipokines. To evaluate if bariatric surgery can serve as a means for altering levels of such EC risk biomarkers, we investigated changes in these biomarkers after weight loss. METHODS: Blood samples were collected pre-operatively and 6months post-operatively in 107 female bariatric surgery patients aged 18-72years...
August 7, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28797672/single-stage-conversion-from-adjustable-gastric-banding-to-sleeve-gastrectomy-or-roux-en-y-gastric-bypass-an-analysis-of-4875-patients
#9
Konstantinos Spaniolas, Andrew T Bates, Salvatore Docimo, Nabeel R Obeid, Mark A Talamini, Aurora D Pryor
BACKGROUND: The previous popularity of adjustable gastric banding (AGB), along with inconsistent long-term results, has resulted in the need for conversion to other procedures. The perioperative safety of laparoscopic sleeve gastrectomy (SG) and gastric bypass (RYGB) as single-stage conversion procedures is unclear. OBJECTIVES: To compare the early safety of SG and RYGB when performed as single-stage conversion procedures at the time of AGB removal. SETTING: Nationwide analysis of accredited centers...
July 15, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28797671/pregnancy-after-bariatric-surgery-the-effect-of-time-to-conception-on-pregnancy-outcomes
#10
Patricia O Yau, Manish Parikh, John K Saunders, Patricia Chui, Tara Zablocki, Akuezunkpa Ude Welcome
BACKGROUND: At our medical center, female patients who have undergone bariatric surgery are advised to defer pregnancy for 2 years after surgery to avoid the following complications and their potential consequences for the fetus: inadequate gestational weight gain, inadequate postsurgical weight loss, hyperemesis gravidarum, nutritional deficiencies, gestational diabetes, and gestational hypertension. OBJECTIVES: To examine the effect of time from surgery to conception on pregnancy course and outcomes in bariatric patients...
July 17, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28797248/the-role-of-bariatric-surgery-to-treat-diabetes-current-challenges-and-perspectives
#11
REVIEW
Chrysi Koliaki, Stavros Liatis, Carel W le Roux, Alexander Kokkinos
Bariatric surgery is emerging as a powerful weapon against severe obesity and type 2 diabetes mellitus (T2DM). Given its role in metabolic regulation, the gastrointestinal tract constitutes a meaningful target to treat T2DM, especially in light of accumulating evidence that surgery with gastrointestinal manipulations may result in T2DM remission (metabolic surgery). The major mechanisms mediating the weight loss-independent effects of bariatric surgery comprise effects on tissue-specific insulin sensitivity, β-cell function and incretin responses, changes in bile acid composition and flow, modifications of gut microbiota, intestinal glucose metabolism and increased brown adipose tissue metabolic activity...
August 10, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/28795980/cognitive-behavioral-therapy-and-predictors-of-weight-loss-in-bariatric-surgery-patients
#12
Linda Paul, Colin van der Heiden, Hans W Hoek
PURPOSE OF REVIEW: Bariatric surgery is the most effective treatment for morbid obesity. However, 20-30% of patients undergoing bariatric surgery experience premature weight stabilization or weight regain postoperatively. We report on the recent literature of predictors of weight loss and the efficacy of cognitive behavioral therapy (CBT) in bariatric patients. RECENT FINDINGS: Preoperative disordered eating behaviors do not appear to be significantly predictive of postoperative weight loss...
August 8, 2017: Current Opinion in Psychiatry
https://www.readbyqxmd.com/read/28795300/five-years-two-surgeons-and-over-500-bariatric-procedures-what-have-we-learned
#13
Brian Shea, William Boyan, James Botta, Syed Ali, Yaniv Fenig, Ethan Paulin, Steven Binenbaum, Frank Borao
BACKGROUND: Bariatric surgery has become an increasingly popular method for weight loss and mitigation of co-morbidities in the obese population. Like any field, there is a desire to standardize and accelerate the postoperative period while maintaining safe outcomes. METHODS: All laparoscopic sleeve gastrectomies (LSG) and gastric bypasses (LGB) were performed over a 5-year period were logged along with several aspects of postoperative care. Trends were followed in aspects of postoperative care over years as well as any documentation of complications or re-admissions...
August 9, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28795291/influence-of-patient-choice-on-outcome-of-bariatric-surgery
#14
P Vasas, S Nehemiah, A Hussain, J Finney, K Kirk, S Yeluri, S Balchandra
BACKGROUND: The "perfect" bariatric procedure remains the topic of debate. The aim of this study is to compare the safety and outcome of laparoscopic Roux-en-Y gastric bypass (LRYGB) to those of laparoscopic sleeve gastrectomy (LSG) and adjustable gastric band (AGB) in a single centre, amongst those patients who made their own choice of which procedure they prefer. METHODS: After the multi-disciplinary team's assessment, the patients could make their own choice of procedures (self-selected, SS), unless medical/surgical conditions limited this (medically restricted, MR)...
August 9, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28795271/efficacy-of-sleeve-gastrectomy-with-duodenal-jejunal-bypass-for-the-treatment-of-obese-severe-diabetes-patients-in-japan-a-retrospective-multicenter-study
#15
Takeshi Naitoh, Kazunori Kasama, Yosuke Seki, Masayuki Ohta, Takashi Oshiro, Akira Sasaki, Yasuhiro Miyazaki, Tsuyoshi Yamaguchi, Hideki Hayashi, Hirofumi Imoto, Naoki Tanaka, Michiaki Unno
BACKGROUND: The incidence of obesity with type 2 diabetes (T2DM) is increasing in Japan. The main bariatric surgery procedures in Japan are laparoscopic sleeve gastrectomy (LSG) and LSG with duodenal-jejunal bypass (LSG/DJB) because of the high incidence of gastric cancer and difficulty exploring a remnant stomach after gastric bypass. However, few studies have compared the antidiabetic effect of LSG/DJB with LSG alone. PURPOSE: The purpose of this study is to compare the antidiabetic effect of LSG/DJB with that of LSG alone in Japanese obese diabetic patients...
August 9, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28794858/monitoring-respiration-and-oxygen-saturation-in-patients-during-the-first-night-after-elective-bariatric-surgery-a-cohort-study
#16
Liselott Wickerts, Sune Forsberg, Frederic Bouvier, Jan Jakobsson
BACKGROUND: Obstructive sleep apnoea and obese hypoventilation is not uncommon in patients with obesity. Residuals effect from surgery/anaesthesia and opioid analgesics may worsen respiration during the first nights after bariatric surgery. The aim of this observational study was to monitor respiration on the first postoperative night following elective bariatric surgery. METHODS: This observational study aimed to determine the incidence and severity of hypo/apnea...
2017: F1000Research
https://www.readbyqxmd.com/read/28794094/outcomes-of-50-patients-entering-an-adolescent-bariatric-surgery-programme
#17
Billy White, Jacqueline Doyle, Kirsten Matschull, Marco Adamo, Deborah Christie, Dasha Nicholls, Sanjay Kinra, Ian Chi Kei Wong, Russell M Viner
OBJECTIVE: Bariatric surgery is the most effective intervention for weight loss and obesity-related comorbidities currently available. Little is known about adolescents entering National Health Service (NHS) bariatric programmes. We aimed to characterise those entering a pathway and report their outcomes. DESIGN: Prospective service evaluation of patients assessed within a single NHS adolescent bariatric service. RESULTS: 50 patients assessed between 26 July 2007 and 27 January 2014; 6 (12%) were not eligible for surgery, 7 (14%) actively opted out, 8 (16%) were lost to follow-up and 29 (58%) underwent surgery (18 sleeve gastrectomy (SG) 11 Roux-en-y gastric bypass (RYGB) and 0 adjustable gastric band)...
August 9, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28791825/effect-of-bmi-on-quality-of-life-and-depression-levels-after-bariatric-surgery
#18
Regina Sierżantowicz, Jolanta Lewko, Hady Razak Hady, Bożena Kirpsza, Lech Trochimowicz, Jacek Dadan
BACKGROUND: Studies conducted in Poland have found that 1% (~300,000) of Polish adults are obese. The degree of weight loss and reduction of discomfort associated with severe obesity are used to evaluate bariatric surgery outcomes. From the patient's point of view, QoL and mental health are the most important determinants of successful surgery, which is why interest in QoL assessment has increased. OBJECTIVES: To assess the effect of BMI on quality of life and depression levels depending on the type of bariatric surgery...
May 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28791623/reoperative-bariatric-surgery-a-systematic-review-of-the-reasons-for-surgery-medical-and-weight-loss-outcomes-relevant-behavioral-factors
#19
REVIEW
Ana Pinto-Bastos, Eva M Conceição, Paulo P P Machado
Reoperative surgery following the failure of primary bariatric surgery is increasing due to the significant rates of patients experiencing poor weight loss or medical complications. This literature review was conducted to organize the emerging, but scattered, literature regarding the reasons for undergoing surgery, the best available options, the predictors of success, and the psychological characteristics of patients submitted to reoperative surgeries. Reoperative procedures are technically challenging, but the possible benefits of reoperation supplant the increased risks associated with these procedures...
August 8, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28791603/development-and-evaluation-of-the-quality-of-life-for-obesity-surgery-qolos-questionnaire
#20
Astrid Müller, Ross D Crosby, Janine Selle, Alexandra Osterhus, Hinrich Köhler, Julian W Mall, Thorsten Meyer, Martina de Zwaan
BACKGROUND AND AIM: Even though health-related quality of life (HRQOL) is considered an important component of bariatric surgery outcome, there is a lack of HRQOL measures relevant for preoperative and postoperative patients. The objective of the current study was to develop a new instrument assessing HRQOL prior to and following bariatric surgery, entitled Quality of Life for Obesity Surgery (QOLOS) Questionnaire. METHODS: Topics for the QOLOS were initially generated via open-ended interviews and focus groups with 19 postoperative bariatric surgery patients...
August 8, 2017: Obesity Surgery
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