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https://www.readbyqxmd.com/read/28549377/biocompatibility-of-liposome-nanocarriers-in-the-rat-inner-ear-after-intratympanic-administration
#1
Jing Zou, Hao Feng, Rohit Sood, Paavo K J Kinnunen, Ilmari Pyykko
Liposome nanocarriers (LPNs) are potentially the future of inner ear therapy due to their high drug loading capacity and efficient uptake in the inner ear after a minimally invasive intratympanic administration. However, information on the biocompatibility of LPNs in the inner ear is lacking. The aim of the present study is to document the biocompatibility of LPNs in the inner ear after intratympanic delivery. LPNs with or without gadolinium-tetra-azacyclo-dodecane-tetra-acetic acid (Gd-DOTA) were delivered to the rats through transtympanic injection...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28549374/metabolic-engineering-of-escherichia-coli-to-high-efficient-synthesis-phenylacetic-acid-from-phenylalanine
#2
Lihua Zhang, Qian Liu, Hong Pan, Xun Li, Daoyi Guo
Phenylacetic acid (PAA) is a fine chemical with a high industrial demand for its widespread uses. Whereas, microorganic synthesis of PAA is impeded by the formation of by-product phenethyl alcohol due to quick, endogenous, and superfluous conversion of aldehydes to their corresponding alcohols, which resulted in less conversation of PAA from aldehydes. In this study, an Escherichia coli K-12 MG1655 strain with reduced aromatic aldehyde reduction (RARE) that does duty for a platform for aromatic aldehyde biosynthesis was used to prompt more PAA biosynthesis...
December 2017: AMB Express
https://www.readbyqxmd.com/read/28549372/pgpr-strain-paenibacillus-polymyxa-sqr-21-potentially-benefits-watermelon-growth-by-re-shaping-root-protein-expression
#3
Yaoyao E, Jun Yuan, Fang Yang, Lei Wang, Jinghua Ma, Jing Li, Xiaowei Pu, Waseem Raza, Qiwei Huang, Qirong Shen
Paenibacillus polymyxa (SQR-21) is not only a plant growth-promoting rhizobacteria, but also an effective biocontrol agent against Fusarium wilt disease of watermelon. For the better understanding and clarifying the potential mechanisms of SQR-21 to improve watermelon growth and disease resistance, a split-root methodology in hydroponic and LC-MS technology with the label free method was used to analyze the key root proteins involved in watermelon metabolism and disease resistance after the inoculation of SQR-21...
December 2017: AMB Express
https://www.readbyqxmd.com/read/28549371/theoretical-analysis-of-coupled-effects-of-microbe-and-root-architecture-on-methane-oxidation-in-vegetated-landfill-covers
#4
S Feng, A K Leung, C W W Ng, H W Liu
Reduction of soil moisture by plant root-water uptake could improve soil aeration for microbial aerobic methane oxidation (MAMO) in a landfill cover, but excessive soil moisture removal could suppress microbial activity due to water shortage. Existing models ignore the coupled microbe-vegetation interaction. It is thus not known whether the presence of plants is beneficial or adverse to MAMO. This study proposes a newly-improved theoretical model that couples the effects of root-water uptake and microbial activity for capturing water-gas flow and MAMO in unsaturated soils...
May 22, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28549370/assessment-of-the-influence-of-key-abiotic-factors-on-the-alternative-microcystin-degradation-pathway-s-mlr-a-detailed-comparison-with-the-mlr-route-mlr
#5
Jesús Morón-López, Lucía Nieto-Reyes, Rehab El-Shehawy
Cyanobacterial proliferation and toxin production in water bodies around the world have led to global concern about the control of these issues. Indigenous bacteria have been shown to degrade the cyanotoxin microcystin (MC) in natural environments. The mlr cluster has been widely used as a marker for microcystin biodegradation; however, recent studies have shown that alternative pathway(s) also contribute to the natural removal of MCs in the ecosystem. The main objective of this study is to provide initial insights concerning how key abiotic factors affect the rate of MC biodegradation via alternative pathway(s) and to provide a detailed comparison with the mlr(+) pathway...
May 22, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28549367/-transfer-of-the-long-head-of-triceps-for-elbow-flexion-in-braquial-plexus-sequelae
#6
E Vergara-Amador, F Vela-Rodríguez
The independent neurovascular anatomy of the long head of the triceps brachii and its suitability as a free muscle transfer have been extensively studied. Instead muscle transposition of the long head of the triceps brachii to enhance elbow flexion has been rarely described. We describe in this paper two cases of injury of brachial plexus sequel in which transposition was performed only on the long head of the triceps. The elbow flexion was improved, the extension was preserved.
November 2016: Acta Ortopédica Mexicana
https://www.readbyqxmd.com/read/28549363/-thoracic-inestability-fixed-with-bioabsorbable-screws-and-plates
#7
A L Nolasco-de la Rosa, R Mosiñoz-Montes, J Matehuala-García, A A Cuautle-Ramírez, E Román-Guzmán, A L Reyes-Miranda, F Quero-Sandoval
BACKGROUND: Flail chest is managed with mechanical ventilation or inhaloteraphy and analgesia. Little has been published on the use of bioabsorbable material and its evolution in flail chest fixation. METHODS: This is a descriptive study of patients with unstable chest undergoing fixation with bioabsorbable plates and screws in a period from February 2009 to December 2011. RESULTS: We report 18 cases, aged 33-74 years (mean 53), three with bilateral involvement; rib fixation was performed between 1-21 days of the accident (mean 1...
November 2016: Acta Ortopédica Mexicana
https://www.readbyqxmd.com/read/28549362/-iliotibial-band-friction-syndrome-due-to-bioabsorbable-pins-in-acl-reconstruction
#8
F Cruz-López, A Mallen-Trejo, C Pascual-Vidriales, A Almazán-Díaz, J C Ibarra-Ponce de León
Injuries of the anterior cruciate ligament are currently treated primarily with the use of hamstring graft with a wide range of different techniques and fixation systems for anterior cruciate ligament in reducing patient morbidity. We report the case of a female patient aged 42 that suffered an anterior cruciate ligament rupture and was treated with anterior cruciate ligament reconstruction with hamstring autograft with femoral fixation with bio-absorbable cross-pin and tibial fixation with bio-absorbable screw...
November 2016: Acta Ortopédica Mexicana
https://www.readbyqxmd.com/read/28549361/-leukocyte-esterase-as-a-diagnostic-tool-for-an-infectious-disease-of-the-knee
#9
S U Ceja-Picazo, S Fuentes-Figueroa, A H Rivera-Villa, A R Hernández-Salgado, R Torres-González, A M Pérez, J A Hernández-García, J M Pérez-Atanasio
BACKGROUND: Articular infection is an orthopedic challenge due to its difficult diagnosis and devastating results. Various diagnostic studies exist: culture, ESR, CRP, count of leukocytes, among others, but none is specific, they all take more than 30 minutes to complete, and require complex infrastructure. In this study, we determine the sensitivity and specificity of the leukocyte esterase for detection of an infectious process joint in Mexican population. MATERIAL AND METHODS: During November 2015 to April 2016, we obtained synovial fluid from two groups of patients: one with a diagnosis of synovial joint infection with or without implant, and the control group, without infection but with degenerative pathology of the knee...
November 2016: Acta Ortopédica Mexicana
https://www.readbyqxmd.com/read/28549360/-intercarpal-fusion-as-a-salvage-procedure-in-kienb%C3%A3-ck-disease
#10
M Puig-Zentella, J A Rivas-Montero, E Hernández-Méndez-Villamil, A J Espinosa-Gutiérrez
INTRODUCTION: Functional results of four surgical techniques to resolve the IIIB-IV Litchman's stage of the Kienböck disease were analyzed. We observed the evolution from 2000 to 2015. MATERIAL AND METHODS: Transversal retrospective study of 33 patients treated with different surgical techniques and evaluated with Quick-DASH scale, dynamometer and EVA. RESULTS: Less functional limitation was found in the patients who underwent the intercarpal fusion with or without neurotomy of the posterior interosseous...
November 2016: Acta Ortopédica Mexicana
https://www.readbyqxmd.com/read/28549359/-bristow-latarjet-technique-for-anterior-glenohumeral-instability
#11
I Jiménez, A Marcos-García, J Medina, G Muratore-Moreno, J Caballero-Martel
BACKGROUND: In treatment of anterior shoulder instability, many surgical techniques have been described, all of them with advantages and disadvantages. Our goal is to study the half term results on patients that underwent open Bristow-Latarjet surgery considering the preoperative ISIS value. MATERIAL AND METHODS: This is a retrospective study of 33 patients which underwent open Bristow-Latarjet surgery in our center between 2005 and 2012. Average age of 33.2 years and follow up of 75 months...
November 2016: Acta Ortopédica Mexicana
https://www.readbyqxmd.com/read/28549358/-complication-analysis-in-lisfranc-fracture-dislocation
#12
R J García-Renedo, A Carranza-Bencano, R Leal-Gómez, F Cámara-Arrigunaga
OBJECTIVE: To value the complications and sequels for patients with Lisfrancs fracture-luxation (FLL). MATERIAL AND METHODS: A transverse ambispective study of cohorts was realized of 83 patients by diagnosis of Lisfrancs fracture-luxation. There was in use a protocol of withdrawal of information with variables related to the injury, clinical, therapeutic parameters, complications and scales of clinical valuation. RESULTS: 66 patients (79...
November 2016: Acta Ortopédica Mexicana
https://www.readbyqxmd.com/read/28549355/predictors-of-language-gains-among-school-age-children-with-language-impairment-in-the-public-schools
#13
Laura M Justice, Hui Jiang, Jessica A Logan, Mary Beth Schmitt
Purpose: This study aimed to identify child-level characteristics that predict gains in language skills for children with language impairment who were receiving therapy within the public schools. The therapy provided represented business-as-usual speech/language treatment provided by speech-language pathologists in the public schools. Method: The sample included 272 kindergartners and first-graders with language impairment who participated in a larger study titled "Speech-Therapy Experiences in the Public Schools...
May 26, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/28549353/crowding-visual-awareness-and-their-respective-neural-loci
#14
Kilho Shin, Susana T L Chung, Bosco S Tjan
In peripheral vision, object identification can be impeded when a target object is flanked by other objects. This phenomenon of crowding has been attributed to basic processes associated with image encoding by the visual system, but the neural origin of crowding is not known. Determining whether crowding depends on subjective awareness of the flankers can provide information on the neural origin of crowding. However, recent studies that manipulated flanker awareness have yielded conflicting results. In the current study, we suppressed flanker awareness with two methods: interocular suppression (IOS) and adaptation-induced blindness (AIB)...
May 1, 2017: Journal of Vision
https://www.readbyqxmd.com/read/28549352/eye-abduction-reduces-but-does-not-eliminate-competition-in-the-oculomotor-system
#15
Paul J Boon, Jan Theeuwes, Artem V Belopolsky
Although it is well established that there is a tight coupling between covert attention and the eye movement system there is an ongoing controversy whether this relationship is functional. Previous studies demonstrated that disrupting the ability to execute an eye movement interferes with the allocation of covert attention. One technique that prevents the execution of an eye movement involves the abduction of the eye in the orbit while presenting the stimuli outside of the effective oculomotor range (Craighero, Nascimben, & Fadiga, 2004)...
May 1, 2017: Journal of Vision
https://www.readbyqxmd.com/read/28549351/contextual-cueing-in-3d-visual-search-depends-on-representations-in-planar-not-depth-defined-space
#16
Xuelian Zang, Zhuanghua Shi, Hermann J Müller, Markus Conci
Learning of spatial inter-item associations can speed up visual search in everyday life, an effect referred to as contextual cueing (Chun & Jiang, 1998). Whereas previous studies investigated contextual cueing primarily using 2D layouts, the current study examined how 3D depth influences contextual learning in visual search. In two experiments, the search items were presented evenly distributed across front and back planes in an initial training session. In the subsequent test session, the search items were either swapped between the front and back planes (Experiment 1) or between the left and right halves (Experiment 2) of the displays...
May 1, 2017: Journal of Vision
https://www.readbyqxmd.com/read/28549350/an-anti-cancer-wxxxe-containing-azurin-polypeptide-inhibits-rac1-dependent-stat3-and-erk-gsk-3%C3%AE-signaling-in-breast-cancer-cells
#17
Zhe Zhang, Zhiyong Luo, Wenpu Min, Lin Zhang, Yaqun Wu, Xiaopeng Hu
In our previous study, we characterized a mycoplasmal small GTPase-like polypeptide of 240 amino acids that possesses an N-terminal WVLGE sequence. The N-terminal WVLGE sequence promotes activation of Rac1 and subsequent host cancer cell proliferation. To investigate the function of the WxxxE motif in the interaction with Rac1 and host tumor progression, we synthesized a 35-amino acid WVLGE-containing polypeptide derived from a cell-penetrating peptide derived from the azurin protein. We verified that the WVLGE-containing polypeptide targeted MCF-7 cells rather than MCF-10A cells...
May 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28549349/synchronous-splenectomy-and-hepatectomy-for-patients-with-small-hepatocellular-carcinoma-and-pathological-spleen-neutrophil-to-lymphocyte-ratio-changes-can-predict-the-prognosis
#18
Xiaoyun Zhang, Chuan Li, Tianfu Wen, Wei Peng, Lunan Yan, Bo Li, Jiayin Yang, Wentao Wang, Mingqing Xu, Yong Zeng
BACKGROUND: Treatments about small hepatocellular carcinoma (HCC) and hypersplenism associated with good hepatic reserve are not well established. The aim of this study was to investigate the outcome of synchronous hepatectomy and splenectomy for those patients. STUDY DESIGN: Splenomegaly and hypersplenism were defined as a pathological spleen. Seven hundred fifty-six patients with small HCC (381 with a pathological spleen, 375 without a pathological spleen) were divided into three groups...
May 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28549348/ocular-toxicities-associated-with-targeted-anticancer-agents-an-analysis-of-clinical-data-with-management-suggestions
#19
Chen Fu, Dan S Gombos, Jared Lee, Goldy C George, Kenneth Hess, Andrew Whyte, David S Hong
Ocular toxicities are among the most common adverse events resulting from targeted anticancer agents and are becoming increasingly relevant in the management of patients on these agents. The purpose of this study is to provide a framework for management of these challenging toxicities based on objective data from FDA labels and from analysis of the literature. All oncologic drugs approved by the FDA up to March 14, 2015, were screened for inclusion. A total of 16 drugs (12 small-molecule drugs and 4 monoclonal antibodies) were analyzed for ocular toxicity profiles based on evidence of ocular toxicity...
May 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/28549345/a-novel-synthetic-derivative-of-quercetin-8-trifluoromethyl-3-5-7-3-4-o-pentamethyl-quercetin-inhibits-bladder-cancer-growth-by-targeting-the-ampk-mtor-signaling-pathway
#20
Ting Tao, Caimei He, Jun Deng, Yanjun Huang, Qiongli Su, Mei Peng, Meiling Yi, Kwame Oteng Darko, Hui Zou, Xiaoping Yang
Quercetin is a naturally existing compound and shows attractive anticancer properties for a variety of solid tumors including glioma, bladder cancer, hepatocellular carcinoma, breast cancer, hematological malignancies and prostate carcinoma. However, these anticancer properties have not been clinically approved due to unclear mechanistic information and its low bioactivity. In our previous study, we elucidated that quercetin activates AMPK pathway which is the major mechanism for its unique anticancer effect in bladder cancer...
May 11, 2017: Oncotarget
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