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https://www.readbyqxmd.com/read/28766279/spectrum-of-pachychoroid-diseases
#1
REVIEW
Sezen Akkaya
PURPOSE: To perform a systematic review of the literature examining about the pachychoroid diseases spectrum. METHODS: A systematic literature search was performed using the Medline database. A total of four studies directly relevant to our search are reviewed here. RESULTS: A structurally and functionally intact choroid tissue is vitally important for the retina function. While central retinal artery is responsible to supply the 2/3, internal part of the retina, choroidal vein network is responsible for the remaining 1/3 external part...
August 1, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28723851/indocyanine-green-angiography-of-pachychoroid-pigment-epitheliopathy
#2
M Giray Ersoz, Serra Arf, Mumin Hocaoglu, Isil Sayman Muslubas, Murat Karacorlu
PURPOSE: To compare choroidal hyperpermeability and vessel density between eyes with central serous chorioretinopathy (CSC), those with pachychoroid pigment epitheliopathy (PPE) and those with uncomplicated pachychoroid (UCP). METHODS: We retrospectively reviewed indocyanine green angiography images of 60 patients with unilateral active CSC who had PPE (36 eyes) or UCP (24 eyes) in their fellow eyes. We used color thresholding of indocyanine green angiography images to determine choroidal vessel density...
July 18, 2017: Retina
https://www.readbyqxmd.com/read/28702676/prevalence-and-risk-factors-for-nonexudative-neovascularization-in-fellow-eyes-of-patients-with-unilateral-age-related-macular-degeneration-and-polypoidal-choroidal-vasculopathy
#3
Yasuo Yanagi, Aditi Mohla, Won-Ki Lee, Shu Yen Lee, Ranjana Mathur, Choi Mun Chan, Ian Yeo, Tien Yin Wong, Chui Ming Gemmy Cheung
Purpose: To determine the prevalence of subclinical nonexudative neovascularization and associated choroidal vascular changes in the fellow eyes of patients presenting with unilateral typical exudative AMD (tAMD) or polypoidal choroidal vasculopathy (PCV) using indocyanine green angiography (ICGA) and swept-source (SS) optical coherence tomography angiography (OCT-A). Methods: We recruited patients presenting with tAMD or PCV in a prospective clinical study. The diagnosis in the presenting eye was determined based on clinical, fluorescein angiography (FA), and ICGA findings...
July 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28626419/shallow-anterior-chamber-in-a-severe-case-of-unilateral-acute-central-serous-retinal-detachment
#4
Ahmet Colakoglu, Banu Cosar
BACKGROUND: Atypical serous chorioretinopathy can present with symptoms similar to those of other pachychoroid diseases; however, a proper differential diagnosis will prevent unnecessary intensive treatments. To this end, we report on the shallowness of anterior chamber and transitory anterior vitreous cells in a patient with atypical severe serous retinal detachment. CASE PRESENTATION: A 42-year-old woman presented with unilateral visual loss accompanied by mild, vague eye pain for 4 days...
May 2017: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/28497336/the-overlapping-spectrum-of-flat-irregular-pigment-epithelial-detachment-investigated-by-optical-coherence-tomography-angiography
#5
Francesco Pichi, Mariachiara Morara, Chiara Veronese, Antonio P Ciardella
PURPOSE: To describe the OCT angiography characteristics of flat irregular pigment epithelial detachments (PEDs), an overlapping tomographic feature of various macular disorders. METHODS: Consecutive patients with a dimpled retinal pigment epithelium profile on OCT, referred for a second opinion, were enrolled. Fluorescein (FA) and indocyanine green angiography (ICGA) were performed in all patients and compared to previous examinations, when available. In all patients, enhanced depth imaging-OCT and OCT angiography were performed upon referral and at subsequent follow-ups...
May 11, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28453367/retinal-pigment-epithelium-photoreceptor-layer-alterations-in-a-patient-with-sturge-weber-syndrome-with-diffuse-choroidal-hemangioma
#6
Solmaz Abdolrahimzadeh, Francesco Parisi, Flavio Mantelli, Andrea Perdicchi, Gianluca Scuderi
PURPOSE: To describe an 8-year-old girl with diagnosis of Sturge-Weber syndrome (SWS) presenting with glaucoma, abnormal iris vessels, diffuse choroidal hemangioma, and small white dot-shaped "microdrusen-like" alterations of the retina in the right eye. PATIENT AND METHODS: Complete ophthalmological examination was performed with slit-lamp anterior segment assessment and fundus ophthalmoscopy. Near infrared reflectance (NIR) and enhanced depth imaging (EDI) spectral domain optical coherence tomography (SD-OCT) were carried out...
April 28, 2017: Ophthalmic Genetics
https://www.readbyqxmd.com/read/28445211/polypoidal-choroidal-vasculopathy-associated-with-central-serous-chorioretinopathy-pachychoroid-spectrum-of-diseases
#7
George J Manayath, Vanee Sheth Shah, Veerappan R Saravanan, Venkatapathy Narendran
PURPOSE: To study multimodal imaging features of polypoidal choroidal vasculopathy (PCV) associated with central serous chorioretinopathy (CSC) in the same eye. METHODS: A retrospective observational study of cases of suspected PCV which underwent indocyanine green angiography, fundus fluorescein angiography and optical coherence tomography was done, to look for simultaneous typical CSC-like active leak in the same eye. The relevant history, best-corrected visual acuity, optical coherence tomography, fundus fluorescein angiography, and indocyanine green angiography findings were analyzed...
April 25, 2017: Retina
https://www.readbyqxmd.com/read/28426630/outer-nuclear-layer-thinning-in-pachychoroid-pigment-epitheliopathy
#8
M Giray Ersoz, Murat Karacorlu, Serra Arf, Mumin Hocaoglu, Isil Sayman Muslubas
PURPOSE: To compare the average thicknesses of central inner retinal layers in eyes with pachychoroid pigment epitheliopathy (PPE), with uncomplicated pachychoroid (UCP), and of healthy subjects. METHODS: Medical records of patients with PPE and UCP were retrospectively reviewed. Twenty-nine eyes with foveal PPE, 30 eyes with UCP, and 29 eyes of healthy subjects were included. Spectral-domain optical coherence tomography with enhanced depth imaging was used for all optical coherence tomography scans...
April 19, 2017: Retina
https://www.readbyqxmd.com/read/28114590/intraocular-vascular-endothelial-growth-factor-levels-in-pachychoroid-neovasculopathy-and-neovascular-age-related-macular-degeneration
#9
Masayuki Hata, Kenji Yamashiro, Sotaro Ooto, Akio Oishi, Hiroshi Tamura, Manabu Miyata, Naoko Ueda-Arakawa, Ayako Takahashi, Akitaka Tsujikawa, Nagahisa Yoshimura
Purpose: To investigate the difference in intraocular vascular endothelial growth factor (VEGF) concentration between pachychoroid neovasculopathy and neovascular age-related macular degeneration (nAMD) and its associations with responses to three monthly anti-VEGF injections as an initial treatment for the two conditions. Methods: This study included nine eyes with treatment-naïve pachychoroid neovasculopathy and 21 eyes with treatment-naïve nAMD. Before the initial intravitreal anti-VEGF injection, aqueous humor samples were collected and the concentration of VEGF was measured using enzyme-linked immunosorbent assay...
January 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28018289/choroidal-and-retinal-abnormalities-by-optical-coherence-tomography-in-endogenous-cushing-s-syndrome
#10
Maria Fernanda Abalem, Marcio Carlos Machado, Helen Nazareth Veloso Dos Santos, Rafael Garcia, John Helal, Pedro Carlos Carricondo, Sérgio Luis Gianotti Pimentel, Mario Luiz Ribeiro Monteiro, Cynthia X Qian, Marcello Delano Bronstein, Maria Cândida Villares Barisson Fragoso
CONTEXT: Cortisol has been suggested as a risk factor for choroidal thickening, which may lead to retinal changes. OBJECTIVE: To compare choroidal thickness measurements using optical coherence tomography (OCT) in patients with endogenous active Cushing's syndrome (CS) and to evaluate the occurrence of retinal abnormalities in the same group of patients. DESIGN: Cross-sectional study. SETTING: Outpatient clinic. PATIENTS: Eleven female patients with CS in hypercortisolism state as determined by the presence of at least two abnormal measurements from urinary cortisol 24 h, no suppression of cortisol with low dose dexamethasone suppression test, and nocturnal salivary cortisol levels and 12 healthy controls...
2016: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28005665/choroidal-morphology-in-eyes-with-polypoidal-choroidal-vasculopathy-and-normal-or-subnormal-subfoveal-choroidal-thickness
#11
Won Ki Lee, Jiwon Baek, Kunal K Dansingani, Jae Hyung Lee, K Bailey Freund
PURPOSE: To subsegment the choroid in patients with polypoidal choroidal vasculopathy and to determine whether the ratio of choriocapillaris/Sattler layer thickness to total choroidal thickness is decreased at sites of polypoidal pathology. METHODS: Retrospective, observational, cross-sectional study. A total of 320 eyes of 305 patients with polypoidal choroidal vasculopathy were studied with optical coherence tomography and dye angiography. The ratio of choriocapillaris/Sattler layer thickness to total choroidal thickness was calculated at polypoidal lesion sites in eyes with subfoveal choroidal thickness (SFCT) ≤200 μm...
December 2016: Retina
https://www.readbyqxmd.com/read/27974321/changes-of-choroidal-structure-after-intravitreal-aflibercept-therapy-for-polypoidal-choroidal-vasculopathy
#12
Erina Daizumoto, Yoshinori Mitamura, Hiroki Sano, Kei Akaiwa, Masanori Niki, Chihiro Yamanaka, Takamasa Kinoshita, Mariko Egawa, Shozo Sonoda, Taiji Sakamoto
AIMS: To quantify the changes of the choroidal structure in the enhanced depth imaging optical coherence tomographic (EDI-OCT) images after intravitreal aflibercept (IVA) injections for polypoidal choroidal vasculopathy (PCV). METHODS: Retrospective, observational case series. Forty eyes of 40 treatment-naive patients who underwent IVA for PCV were examined by EDI-OCT before, and 3 months and 12 months after IVA. The EDI-OCT images were binarised by ImageJ software...
January 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27847643/novel-perspectives-on-swept-source-optical-coherence-tomography
#13
REVIEW
Fabio Lavinsky, Daniel Lavinsky
Technologies for multimodal digital imaging of vitreoretinal diseases have improved the accuracy of diagnosis and the depth of the knowledge of the mechanisms of disease and their response to treatments. Optic coherence tomography (OCT) has become a mandatory tool for the management and for the follow-up of retinal pathologies. OCT technology evolved in the last two decades from time-domain to spectral domain and recently to the swept-source OCTs (SS-OCT). SS-OCT improved the depth of imaging and the scan speed, thus adding novel algorithms and features such as for vitreous and vitreoretinal interface evaluation, choroid segmentation and mapping, OCT angiography and En-face OCT...
2016: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/27824724/multiple-evanescent-white-dot-syndrome-with-central-visual-loss
#14
REVIEW
Gaetano R Barile, Sarah A Harmon
PURPOSE: To report the clinical case of a 64-year-old man who developed several features of multiple evanescent white dot syndrome (MEWDS) but with central visual loss that persisted because of significant structural macular disease. METHODS: A case report was generated by a review of the clinical course and imaging investigations of one patient, along with review of the literature. RESULTS: A 64-year-old man noted decreased vision in the right eye for 2 weeks, associated with a central scotoma with shimmering, gauze effect of the vision...
January 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/27749785/choroidal-morphology-in-eyes-with-polypoidal-choroidal-vasculopathy-and-normal-or-subnormal-subfoveal-choroidal-thickness
#15
Won Ki Lee, Jiwon Baek, Kunal K Dansingani, Jae Hyung Lee, K Bailey Freund
PURPOSE: To subsegment the choroid in patients with polypoidal choroidal vasculopathy and to determine whether the ratio of choriocapillaris/Sattler layer thickness to total choroidal thickness is decreased at sites of polypoidal pathology. METHODS: Retrospective, observational, cross-sectional study. A total of 320 eyes of 305 patients with polypoidal choroidal vasculopathy were studied with optical coherence tomography and dye angiography. The ratio of choriocapillaris/Sattler layer thickness to total choroidal thickness was calculated at polypoidal lesion sites in eyes with subfoveal choroidal thickness (SFCT) ≤200 μm...
October 3, 2016: Retina
https://www.readbyqxmd.com/read/27749784/focal-choroidal-excavation-and-its-association-with-pachychoroid-spectrum-disorders-a-review-of-the-literature-and-multimodal-imaging-findings
#16
REVIEW
Hyewon Chung, Suk Ho Byeon, K Bailey Freund
PURPOSE: To review the literature regarding focal choroidal excavation and show its association with pachychoroid features through case examples. METHODS: The clinical manifestations of focal choroidal excavation are illustrated with various imaging modalities inclusive of fundus photography, fundus autofluorescence, fluorescein angiography, indocyanine green angiography, spectral domain optical coherence tomography (OCT), enhanced depth imaging OCT, and swept-source OCT...
February 2017: Retina
https://www.readbyqxmd.com/read/27685502/retinal-detachment-associated-with-peripheral-tear-of-the-retinal-pigment-epithelium-in-pachychoroid-spectrum-disease
#17
Mikel Mikhail, Nour Nofal, Mikael Sebag
PURPOSE: To describe a rare case of an exudative retinal detachment associated with a peripheral tear of the retinal pigment epithelium in a young myopic pachychoroid eye. METHODS: Clinical case report and literature review. Imaging was obtained with color fundus photography, spectral domain optical coherence tomography, fluorescein angiography, and fluorescein angiography. RESULTS: A 33-year-old white man presented with an exudative choroidopathy resulting in an exudative neurosensory detachment, associated with peripheral retinal pigment epithelium tears...
January 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/27627749/mineralocorticoid-receptor-antagonist-treatment-in-bilateral-chronic-central-serous-chorioretinopathy-a-comparative-study-of-exudative-and-nonexudative-fellow-eyes
#18
Róbert Gergely, Illés Kovács, Miklós Schneider, Miklós Resch, András Papp, Zsuzsanna Récsán, Zoltán Zsolt Nagy, Mónika Ecsedy
PURPOSE: To evaluate the macular thickness, choroidal thickness, and visual acuity changes in eyes of patients with bilateral chronic central serous chorioretinopathy during eplerenone treatment. METHODS: This prospective clinical trial was conducted on patients with bilateral chronic central serous chorioretinopathy, who had subretinal fluid (SRF) in 1 eye. Twenty-eight patients were treated with 50 mg/day of oral eplerenone for 3 months and were observed for another 3 months...
June 2017: Retina
https://www.readbyqxmd.com/read/27597633/pachychoroid-neovasculopathy-aspect-on-optical-coherence-tomography-angiography
#19
Georges Azar, Benjamin Wolff, Martine Mauget-Faÿsse, Marco Rispoli, Maria-Cristina Savastano, Bruno Lumbroso
PURPOSE: To describe and interpret the features of pachychoroid neovasculopathy (PNV) using optical coherence tomography angiography (OCTA) technique. METHODS: This is an observational case series of patients who presented with PNV. Best-corrected visual acuity (BCVA), anterior segment examination, dilated funduscopic examination, infrared and autofluorescence fundus images and spectral-domain optical coherence tomography (SD-OCT; B-scan, 'en-face' and OCTA) were carried out for all patients...
September 6, 2016: Acta Ophthalmologica
https://www.readbyqxmd.com/read/27583829/peripapillary-pachychoroid-in-nonarteritic-anterior-ischemic-optic-neuropathy
#20
Lina Nagia, Carrie Huisingh, John Johnstone, Lanning B Kline, Mark Clark, Michael J A Girard, Jean Martial Mari, Christopher A Girkin
PURPOSE: This study examined the peripapillary choroidal thickness (PCT) in nonarteritic ischemic optic neuropathy (NAION) in comparison to contralateral eyes and normal eyes. METHODS: We used enhanced depth imaging spectral-domain optical coherence tomography to image the optic nerve head of 20 NAION, 10 contralateral eyes, and 102 normal eyes. Following compensation, the scans were manually delineated to identify relevant surfaces including Bruch's membrane opening (BMO), Bruch's membrane, and anterior sclera...
September 1, 2016: Investigative Ophthalmology & Visual Science
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