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https://www.readbyqxmd.com/read/28005720/fundus-autofluorescence-in-rubella-retinopathy-correlation-with-photoreceptor-structure-and-function
#1
Danuta M Bukowska, Sue Ling Wan, Avenell L Chew, Enid Chelva, Ivy Tang, David A Mackey, Fred K Chen
PURPOSE: To illustrate altered fundus autofluorescence in rubella retinopathy and to investigate their relationships with photoreceptor structure and function using multimodal imaging. METHODS: The authors report four cases of rubella retinopathy aged 8, 33, 42, and 50 years. All patients had dilated clinical fundus examination; wide-field color photography; blue, green, and near-infrared autofluorescence imaging and spectral domain optical coherence tomography...
January 2017: Retina
https://www.readbyqxmd.com/read/27984836/-do-we-still-need-electrophysiology-in-ophthalmology
#2
H Tegetmeyer
Electrophysiological methods in clinical ophthalmology include the full-field electroretinogram (ERG) for assessment of outer and middle retinal layers, pattern ERG (PERG) for assessment of ganglion cell function, the electrooculogram (EOG) for assessment of retinal pigment epithelium function, as well as visual evoked potentials (VEP) for assessment of the visual pathway, including the optic nerve and visual cortex. Multifocal recording techniques for ERG and VEP are used for tests within selected areas of the visual field...
December 2016: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/27977838/multimodal-imaging-features-in-acute-exudative-paraneoplastic-polymorphous-vitelliform-maculopathy
#3
Daniel Q Li, John Golding, Carl Glittenberg, Netan Choudhry
An 85-year-old woman with stage IV breast cancer was referred for gradually progressive blurred vision. Dilated fundus examination revealed unifocal, yellow, round vitelliform lesions in the macular region of both eyes. The diagnosis of acute exudative paraneoplastic polymorphous vitelliform maculopathy (AEPPVM) was confirmed with swept-source optical coherence tomography (SS-OCT), fundus autofluorescence, and fluorescein angiography. SS-OCT angiography revealed normal vascular findings in both eyes. Multimodal imaging is useful in the diagnosis and monitoring of AEPPVM and may further the understanding of its pathophysiology...
December 1, 2016: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/27902541/central-serous-chorioretinopathylike-mimicking-multifocal-vitelliform-macular-dystrophy-an-ocular-side-effect-of-mitogen-extracellular-signal-regulated-kinase-inhibitors
#4
Chiara Giuffrè, Elisabetta Miserocchi, Giulio Modorati, Adriano Carnevali, Alessandro Marchese, Lea Querques, Giuseppe Querques, Francesco Bandello
PURPOSE: To describe a case of multiple detachments of the neurosensory retina mimicking multifocal vitelliform macular dystrophy after chemotherapy with mitogen/extracellular signal-regulated kinase inhibitor for metastatic ovarian cancer. METHODS: Case report. RESULTS: A 38-year-old woman presented to our clinic for eye examination before the initiation of chemotherapy with trametinib. One month after starting treatment, the patient complained of vision loss and metamorphopsia in both eyes...
November 29, 2016: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/27867022/choroidal-neovascularization-secondary-to-best-vitelliform-macular-dystrophy-detected-by-optical-coherence-tomography-angiography
#5
Rida Shahzad, Muhammad Abdul Rehman Siddiqui
Best vitelliform macular dystrophy (VMD) is a hereditary condition that causes childhood-onset macular dystrophy. In rare cases, VMD is accompanied by formation of a choroidal neovascular membrane (CNVM). We report a case of CNVM secondary to Best VMD in a 10-year-old boy that was detected using optical coherence tomography angiography, a new noninvasive diagnostic modality that detects motion contrast in repeated B-scans to identify blood flow within vessels.
November 17, 2016: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/27847623/choroidal-thickness-using-edi-oct-in-adult-onset-vitelliform-macular-dystrophy
#6
Renato Menezes Palácios, Thaís Sousa Mendes, Ronaldo Yuiti Sano, Davi Chen Wu, Teruo Aihara, Roberta Pereira de Almeida Manzano
BACKGROUND: To compare choroidal thickness in patients with adult-onset foveomacular vitelliform dystrophy (AOFVD) with healthy subjects and to correlate choroidal thickness with age, gender and spherical equivalent. METHODS: A prospective, observational study of 37 eyes (15 eyes in AOFVD group and 22 eyes in control group) was conducted. Images were acquired by enhanced depth imaging optical coherence tomography (EDI-OCT). Choroidal thickness measurements were performed in the subfoveal region and at 500, 1000 and 1500 µm intervals from the foveal center to nasal and to temporal regions for subsequent averaging of values...
2016: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/27775230/clinical-and-genetic-heterogeneity-in-slovenian-patients-with-best-disease
#7
Damjan Glavač, Martina Jarc-Vidmar, Katarina Vrabec, Metka Ravnik-Glavač, Ana Fakin, Marko Hawlina
PURPOSE: To determine the spectrum of BEST1 mutations and to study the phenotype in Slovenian families with Best vitelliform macular dystrophy (BVMD) to identify genotype-phenotype correlations. METHODS: Twenty patients from five families underwent the ophthalmological examination including electrooculogram (EOG; N = 17), fundus autofluorescence imaging (N = 16) and optical coherence tomography (N = 14). Mutational screening was performed by direct DNA sequencing of the BEST1 gene...
December 2016: Acta Ophthalmologica
https://www.readbyqxmd.com/read/27760262/associations-between-retinal-pigment-epithelium-and-drusen-volume-changes-during-the-lifecycle-of-large-drusenoid-pigment-epithelial-detachments
#8
Chandrakumar Balaratnasingam, Lawrence A Yannuzzi, Christine A Curcio, William H Morgan, Giuseppe Querques, Vittorio Capuano, Eric Souied, Jesse Jung, K Bailey Freund
Purpose: Drusenoid pigment epithelial detachments (PEDs) are a defined path to atrophy in age-related macular degeneration (AMD). We analyzed the relationships between retinal pigment epithelium (RPE) and drusen volume changes during the PED lifecycle, using spectral-domain optical coherence tomography (SD-OCT). Methods: Twenty-one cases of drusenoid PED tracked using SD-OCT through periods of growth and collapse were evaluated. Volumetric calculations and piece-wise linear regression analysis were used to determine the breakpoint between growth and collapse...
October 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27716122/atypical-presentation-of-primary-intraocular-lymphoma
#9
Koji Komatsu, Tsutomu Sakai, Toshikatsu Kaburaki, Hideki Tsuji, Hiroshi Tsuneoka
BACKGROUND: In 2014, Pang et al. reported three cases with vitelliform submaculopathy as a preceding lesion of primary intraocular lymphoma (PIOL). Here, we report a case with an atypical presentation of PIOL who initially presented with vitelliform submaculopathy, vitreous haze and preripheral retinal focus. CASE PRESENTATION: A 73-year-old female initially visited another hospital with a chief complaint of acute reduced vision in the right eye. Funduscopic examination of the right eye showed a yellowish retinal lesion at the fovea with vitreous haze and retinal foci scattered in the peripheral region...
October 3, 2016: BMC Ophthalmology
https://www.readbyqxmd.com/read/27685498/a-case-of-cone-dystrophy-associated-with-choroidal-neovascularization
#10
Gokhan Gulkilik, Sevil Karaman Erdur, Mustafa Eliacik, Mahmut Odabasi, Mustafa Ozsutcu, Goktug Demirci, Mehmet Selim Kocabora
PURPOSE: To report a case of choroidal neovascularization (CNV) in a patient with cone dystrophy (CD). METHODS: Case report. RESULTS: A 20-year-old woman presented with diminished vision in her right eye. Fundus examination showed perifoveal retinal pigment epithelial changes and retinal hemorrhage consistent with subretinal CNV in the right eye, and mild retinal pigment epithelial changes with a dull foveal reflex in the left eye. Optical coherence tomography analysis and fundus fluorescein angiography also confirmed the subfoveal CNV in the right eye...
September 28, 2016: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/27668931/torpedo-maculopathy-presenting-with-a-vitelliform-lesion
#11
Rosa Dolz-Marco, Norman A Saffra, K Bailey Freund
No abstract text is available yet for this article.
September 23, 2016: Retina
https://www.readbyqxmd.com/read/27640006/clinical-characteristics-choroidal-neovascularization-and-predictors-of-visual-outcomes-in-acquired-vitelliform-lesions
#12
Chandrakumar Balaratnasingam, Quan V Hoang, Maiko Inoue, Christine A Curcio, Rosa Dolz-Marco, Nicolas A Yannuzzi, Elona Dhrami-Gavazi, Lawrence A Yannuzzi, K Bailey Freund
PURPOSE: To quantify the temporal properties of the acquired vitelliform lesion (AVL) lifecycle, define the clinical characteristics of choroidal neovascularization (NV) in this setting and determine the predictors of long-term visual outcomes. DESIGN: Retrospective cohort study METHODS: Clinical and imaging data from 199 eyes of 124 consecutive patients with AVLs associated with age-related macular degeneration (AMD) and adult-onset foveomacular vitelliform dystrophy (AOFVD) were analyzed...
September 14, 2016: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/27558081/bilateral-choroidal-neovascularisation-associated-with-adult-onset-foveomacular-vitelliform-dystrophy
#13
Cheryl P Au, Vivek B Pandya, Paul Mitchell
No abstract text is available yet for this article.
January 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/27533784/focal-choroidal-excavation-in-retinal-dystrophies
#14
Imoro Zeba Braimah, Shruthi Rapole, Sunila Dumpala, Jay Chhablani
AIM: To investigate the presence of focal choroidal excavation (FCE) in patients with retinitis pigmentosa (RP), Stargardt's disease (STGD), and Best disease in the Indian population. METHODS: This retrospective consecutive case series included 309 eyes of 157 patients with RP (183 eyes), STGD (93 eyes), and Best disease (33 eyes) with good-quality, enhanced-depth spectral domain optical coherence tomography scans. Comprehensive ophthalmic examination data were collected...
August 17, 2016: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/27533643/paraneoplastic-vitelliform-maculopathy-in-the-setting-of-choroidal-melanoma-evolution-over-one-year
#15
Aaron Nagiel, Daniel B Rootman, Tara A McCannel
BACKGROUND: To illustrate the evolution of paraneoplastic vitelliform maculopathy over one year using optical coherence tomography. METHODS: Observational case report. RESULTS: A 65-year-old man with a history of ocular melanocytosis and choroidal melanoma of the left eye treated with plaque brachytherapy 3 years prior returned for his yearly follow-up visit. The visual acuity in the right eye was 20/20. Subtle thickening of the interdigitation zone layer was noted on optical coherence tomography...
January 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/27467379/photoreceptor-inner-segment-morphology-in-best-vitelliform-macular-dystrophy
#16
Drew Scoles, Yusufu N Sulai, Robert F Cooper, Brian P Higgins, Ryan D Johnson, Joseph Carroll, Alfredo Dubra, Kimberly E Stepien
PURPOSE: To characterize outer retina structure in best vitelliform macular dystrophy (BVMD) and to determine the effect of macular lesions on overlying and adjacent photoreceptors. METHODS: Five individuals with BVMD were followed prospectively with spectral domain optical coherence tomography and confocal and nonconfocal split-detector adaptive optics scanning light ophthalmoscopy (AOSLO). The AOSLO cone photoreceptor mosaic images were obtained within and around retinal lesions...
October 3, 2016: Retina
https://www.readbyqxmd.com/read/27446487/cell-specific-promoters-enable-lipid-based-nanoparticles-to-deliver-genes-to-specific-cells-of-the-retina-in-vivo
#17
Yuhong Wang, Ammaji Rajala, Binrui Cao, Michelle Ranjo-Bishop, Martin-Paul Agbaga, Chuanbin Mao, Raju V S Rajala
Non-viral vectors, such as lipid-based nanoparticles (liposome-protamine-DNA complex [LPD]), could be used to deliver a functional gene to the retina to correct visual function and treat blindness. However, one of the limitations of LPD is the lack of cell specificity, as the retina is composed of seven types of cells. If the same gene is expressed in multiple cell types or is absent from one desired cell type, LPD-mediated gene delivery to every cell may have off-target effects. To circumvent this problem, we have tested LPD-mediated gene delivery using various generalized, modified, and retinal cell-specific promoters...
2016: Theranostics
https://www.readbyqxmd.com/read/27349411/subretinal-hyperreflective-material-imaged-with-optical-coherence-tomography-angiography
#18
Kunal K Dansingani, Anna C S Tan, Fatimah Gilani, Nopasak Phasukkijwatana, Eduardo Novais, Lea Querques, Nadia K Waheed, Jay S Duker, Giuseppe Querques, Lawrence A Yannuzzi, David Sarraf, K Bailey Freund
PURPOSE: The range of subretinal hyperreflective material (SHRM) seen in macular disease includes type 2 macular neovascularization, fibrosis, exudation, vitelliform material, and hemorrhage. The prognostic significance of SHRM has been evaluated retrospectively in clinical trials, but discriminating SHRM subtypes traditionally requires multiple imaging modalities. The purpose of this study is to describe optical coherence tomography angiography (OCTA) flow characteristics and artifacts that might help to distinguish SHRM subtypes...
September 2016: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/27336230/optical-coherence-tomography-angiography-of-choroidal-neovascularization-in-four-inherited-retinal-dystrophies
#19
Rachel C Patel, Simon S Gao, Miao Zhang, Talal Alabduljalil, Abdullah Al-Qahtani, Richard G Weleber, Paul Yang, Yali Jia, David Huang, Mark E Pennesi
PURPOSE: To demonstrate the clinical utility of optical coherence tomography (OCT) angiography (OCT-A) in inherited retinal dystrophies complicated by choroidal neovascularization (CNV). METHODS: Optical coherence tomography angiography and structural OCT were performed using a 70-kHz spectral domain OCT system using the split-spectrum amplitude-decorrelation angiography algorithm. Semiautomated image processing software was used to segment and measure the CNV. RESULTS: Four participants were enrolled to study the following inherited retinal dystrophies complicated by CNV: choroideremia, EFEMP1-related retinopathy, Best vitelliform dystrophy, and adult-onset vitelliform dystrophy...
December 2016: Retina
https://www.readbyqxmd.com/read/27315323/ocular-manifestations-of-monoclonal-immunoglobulin-light-chain-deposition-disease
#20
Elona Dhrami-Gavazi, K Bailey Freund, Winston Lee, Ben Z Cohen, Surya V Seshan, Lawrence A Yannuzzi
PURPOSE: To demonstrate unusual retinal findings in a patient with progressive renal failure due to idiopathic monoclonal immunoglobulin light chain deposition disease, using multimodal imaging. METHODS: Observational case report of a 43-year-old white man with renal failure due to light chain deposition disease. His course over 6 years was documented with multimodal imaging including fundus photography, fundus autofluorescence, fluorescein angiography, and spectral domain optical coherence tomography...
June 16, 2016: Retinal Cases & Brief Reports
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