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age-related macular degeneration

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https://www.readbyqxmd.com/read/29036897/inhibition-of-starvation-triggered-endoplasmic-reticulum-stress-autophagy-and-apoptosis-in-arpe-19-cells-by-taurine-through-modulating-the-expression-of-calpain-1-and-calpain-2
#1
Yuanyuan Zhang, Shu Ren, Yuci Liu, Kun Gao, Zheng Liu, Zhou Zhang
Age-related macular degeneration (AMD) is a complex disease with multiple initiators and pathways that converge on death for retinal pigment epithelial (RPE) cells. In this study, effects of taurine on calpains, autophagy, endoplasmic reticulum (ER) stress, and apoptosis in ARPE-19 cells (a human RPE cell line) were investigated. We first confirmed that autophagy, ER stress and apoptosis in ARPE-19 cells were induced by Earle's balanced salt solution (EBSS) through starvation to induce RPE metabolic stress...
October 14, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29035128/prospective-study-of-plasma-homocysteine-its-dietary-determinants-and-risk-of-age-related-macular-degeneration-in-men
#2
William G Christen, Nancy R Cook, Stephanie E Chiuve, Paul M Ridker, J Michael Gaziano
PURPOSE: Cross-sectional and case-control studies generally support a direct association between elevated plasma homocysteine and age-related macular degeneration (AMD), but data from prospective studies are limited. We examined the prospective relation of plasma homocysteine level, its dietary determinants, and risk of AMD in a large cohort of apparently healthy male physicians. METHODS: During a mean follow-up of 11.2 years, we identified 146 incident cases of visually significant AMD (responsible for a reduction of visual acuity to 20/30 or worse), and 146 controls matched for age, smoking status, and time of blood draw...
October 16, 2017: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/29034584/modern-therapeutic-approaches-for-noninfectious-ocular-diseases-involving-inflammation
#3
REVIEW
Michelle L Ratay, Elena Bellotti, Riccardo Gottardi, Steven R Little
Dry eye disease, age-related macular degeneration, and uveitis are ocular diseases that significantly affect the quality of life of millions of people each year. In these diseases, the action of chemokines, proinflammatory cytokines, and immune cells drives a local inflammatory response that results in ocular tissue damage. Multiple therapeutic strategies are developed to either address the symptoms or abate the underlying cause of these diseases. Herein, the challenges to deliver drugs to the relevant location in the eye for each of these diseases are reviewed along with current and innovative therapeutic approaches that attempt to restore homeostasis within the ocular microenvironment...
October 16, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29034359/the-definition-rationale-and-effects-of-thresholding-in-oct-angiography
#4
Emily D Cole, Eric M Moult, Sabin Dang, WooJhon Choi, Stefan B Ploner, ByungKun Lee, Ricardo Louzada, Eduardo Novais, Julia Schottenhamml, Lennart Husvogt, Andreas Maier, James G Fujimoto, Nadia K Waheed, Jay S Duker
PURPOSE: To examine the definition, rationale, and effects of thresholding in OCT angiography (OCTA). DESIGN: A theoretical description of OCTA thresholding in combination with qualitative and quantitative analysis of the effects of OCTA thresholding in eyes from a retrospective case series. PARTICIPANTS: Four eyes were qualitatively examined: 1 from a 27-year-old control, 1 from a 78-year-old exudative age-related macular degeneration (AMD) patient, 1 from a 58-year-old myopic patient, and 1 from a 77-year-old nonexudative AMD patient with geographic atrophy (GA)...
September 2017: Ophthalmology retina
https://www.readbyqxmd.com/read/29033536/spotlight-on-reticular-pseudodrusen
#5
REVIEW
Alessandro Rabiolo, Riccardo Sacconi, Maria Vittoria Cicinelli, Lea Querques, Francesco Bandello, Giuseppe Querques
Age-related macular degeneration (AMD) is a leading cause of vision loss in patients >50 years old. The hallmark of the disease is represented by the accumulation of extracellular material between retinal pigment epithelium and the inner collagenous layer of Bruch's membrane, called drusen. Although identified almost 30 years ago, reticular pseudodrusen (RPD) have been recently recognized as a distinctive phenotype. Unlike drusen, they are located in the subretinal space. RPD are strongly associated with late AMD, especially geographic atrophy, type 2 and 3 choroidal neovascularization, which, in turn, are less common in typical AMD...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29032853/genetic-polymorphisms-of-cfh-and-arms2-do-not-predict-response-to-antioxidants-and-zinc-in-patients-with-age-related-macular-degeneration-independent-statistical-evaluations-of-data-from-the-age-related-eye-disease-study
#6
Melissa J Assel, Fan Li, Ying Wang, Andrew S Allen, Keith A Baggerly, Andrew J Vickers
PURPOSE: Considerable controversy has erupted in recent years regarding whether genotyping should be part of standard care for patients with age-related macular degeneration (AMD) who are being considered for treatment with antioxidants and zinc. We aimed to determine whether genotype predicts response to supplements in AMD. DESIGN: Three separate statistical teams reanalyzed data derived from the Age-Related Eye Disease Study (AREDS), receiving data prepared by the AREDS investigators and, separately, data from investigators reporting findings that support the use of genotyping...
October 9, 2017: Ophthalmology
https://www.readbyqxmd.com/read/29032195/global-causes-of-blindness-and-distance-vision-impairment-1990-2020-a-systematic-review-and-meta-analysis
#7
Seth R Flaxman, Rupert R A Bourne, Serge Resnikoff, Peter Ackland, Tasanee Braithwaite, Maria V Cicinelli, Aditi Das, Jost B Jonas, Jill Keeffe, John H Kempen, Janet Leasher, Hans Limburg, Kovin Naidoo, Konrad Pesudovs, Alex Silvester, Gretchen A Stevens, Nina Tahhan, Tien Y Wong, Hugh R Taylor
BACKGROUND: Contemporary data for causes of vision impairment and blindness form an important basis of recommendations in public health policies. Refreshment of the Global Vision Database with recently published data sources permitted modelling of cause of vision loss data from 1990 to 2015, further disaggregation by cause, and forecasts to 2020. METHODS: In this systematic review and meta-analysis, we analysed published and unpublished population-based data for the causes of vision impairment and blindness from 1980 to 2014...
October 10, 2017: Lancet Global Health
https://www.readbyqxmd.com/read/29030303/electrospun-formulations-of-bevacizumab-for-sustained-release-in-the-eye
#8
Ukrit Angkawinitwong, Sahar Awwad, Peng T Khaw, Steve Brocchini, Gareth R Williams
Medicines based on vascular endothelial growth factor (VEGF) neutralising antibodies such as bevacizumab have revolutionized the treatment of age related macular degeneration (AMD), a common blinding disease, and have great potential in preventing scarring after surgery or accelerating the healing of corneal injuries. However, at present, frequent invasive injections are required to deliver these antibodies. Such administration is uncomfortable for patients and expensive for health service providers. Much effort is thus focused on developing dosage forms that can be administered less frequently...
October 10, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29027953/vitamin-d-and-age-related-macular-degeneration
#9
REVIEW
Alfredo Garcia Layana, Angelo Maria Minnella, Gerhard Garhöfer, Tariq Aslam, Frank G Holz, Anita Leys, Rufino Silva, Cécile Delcourt, Eric Souied, Johanna M Seddon
In recent years, the relationship between vitamin D and health has received growing attention from the scientific and medical communities. Vitamin D deficiencies have been repeatedly associated with various acute and chronic diseases, including age-related macular degeneration (AMD). Its active metabolite, 1α,25-dihydoxy vitamin D, acts as a modulator of cell proliferation, differentiation and apoptosis, and cumulative data from experimental and observational studies suggest that relatively a lower vitamin D status could be a potential risk factor for the development of early and/or late AMD...
October 13, 2017: Nutrients
https://www.readbyqxmd.com/read/29027065/blood-coagulation-parameters-after-intravitreal-injection-of-aflibercept-in-patients-with-neovascular-age-related-macular-degeneration
#10
Hasan Altinkaynak, Meltem Ece Kars, Piraye Zeynep Kurkcuoglu, Nagihan Ugurlu
PURPOSE: The aim of this study was to evaluate the effect of intravitreal injection of aflibercept (IVA) on blood coagulation tests in neovascular age-related macular degeneration (AMD) patients. METHODS: Thirty-four patients with neovascular AMD (study group) and 32 healthy individuals (control group) were enrolled. Prothrombin time (PT) and activated partial thromboplastin time (aPTT) were measured at different times in patients with neovascular AMD. RESULTS: The levels of PT and aPTT after IVA were decreased at 1 month after the first injection and 1 month after the second injection compared to the baseline measurement in the study group...
October 12, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/29026187/comment-on-one-year-real-world-outcomes-in-patients-receiving-fixed-dosing-aflibercept-for-neovascular-age-related-macular-degeneration
#11
https://www.readbyqxmd.com/read/29025176/-real-life-evidence-on-treatment-outcomes-of-neovascular-age-related-macular-degeneration-in-germany
#12
Robert Patrick Finger, Thomas Wecker, Andreas Stahl, Matthias Grüb, Frank G Holz, Helmut G Sachs, Robert Wilke
Treatment of neovascular age-related macular degeneration (AMD) with anti-vascular endothelial growth factor agents has been improved since its introduction in Germany. Several observational studies have demonstrated an increased frequency of injections in parallel with improved visual outcomes during the first year of treatment over the last 7 years. These results are reflected in several case series. However, studies with a longer follow-up reported that visual function regressed to baseline vision following an initial improvement, e...
October 12, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29025174/-change-in-therapy-of-neovascular-age-related-macular-degeneration-diabetic-maculopathy-and-macular-edema-after-retinal-vein-occlusion
#13
Matthias Grüb, Ioannis Lamprakis, Christoph Reichel
Background Therapy of neovascular age-related macular degeneration, diabetic maculopathy and macular edema after retinal vein occlusion has changed fundamentally since the introduction of anti-VEGF therapy more than 10 years ago. With the technological progress in ocular coherence tomography (OCT) functional criteria have been replaced by more morphological criteria. Contract law and administrative problems have been improved but not solved totally. Patients/Materials and Methods In a retrospective study, 207 eyes of 157 patients who presented between January 2007 and October 2013 with neovascular age-related macular degeneration, diabetic maculopathy or macular edema after retinal vein occlusion were analyzed...
October 12, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29025108/hdl-cholesterol-levels-and-risk-of-age-related-macular-degeneration-a-multiethnic-genetic-study-using-mendelian-randomization
#14
Qiao Fan, Joseph C Maranville, Lars Fritsche, Xueling Sim, Chui Ming Gemmy Cheung, Li Jia Chen, Mathias Gorski, Kenji Yamashiro, Jeeyun Ahn, Augustinus Laude, Rajkumar Dorajoo, Tock Han Lim, Yik-Ying Teo, Robert O Blaustein, Nagahisa Yoshimura, Kyu-Hyung Park, Chi Pui Pang, E Shyong Tai, Chiea Chuen Khor, Tien Yin Wong, Heiko Runz, Ching-Yu Cheng
Background: Dyslipidemia, particularly high-density lipoprotein cholesterol (HDL-C), has recently been implicated in the pathogenesis of age-related macular degeneration (AMD), the leading cause of vision loss. However, epidemiological studies have yielded conflicting results. Methods: We investigated the causal role of plasma lipid levels in AMD in multiethnic populations comprising 16 144 advanced AMD cases and 17 832 controls of European descent, together with 2219 cases and 5275 controls of Asian descent, using Mendelian randomization in three models...
September 12, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29022897/cooperation-of-rel-family-members-in-regulating-a%C3%AE-1-40-mediated-pro-inflammatory-cytokine-secretion-by-retinal-pigment-epithelial-cells
#15
Junran Sun, Peirong Huang, Jian Liang, Jie Li, Mengxi Shen, Xiangjun She, Yiji Feng, Xueting Luo, Te Liu, Xiaodong Sun
Amyloid-beta (Aβ) is a hallmark component of age-related macular degeneration (AMD), which induces secretion of pro-inflammatory cytokines from retinal pigment epithelium (RPE). Previous studies have shown that p50/RelA (p65), a member of NF-κB family, is an essential pro-inflammatory transcription factor responding to Aβ1-40 stimulation, but few focused on the other two Rel transcription factor members - RelB and c-Rel - and their role in Aβ1-40-mediated inflammation. It was reported that RelA, RelB and c-Rel are also implicated in various NF-κB-mediated inflammatory diseases...
October 12, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29022298/patient-awareness-of-cataract-and-age-related-macular-degeneration-among-the-korean-elderly-a-population-based-study
#16
Hankil Lee, Yong Jung Jang, Hyung Keun Lee, Hye Young Kang
PURPOSE: Age-related eye disease is often considered part of natural aging. Lack of awareness of eye conditions can result in missed treatment. We investigated the rates of awareness of cataract and age-related macular degeneration, the most common age-related eye-diseases, and the associated factors among elderly Koreans. METHODS: We identified 7,403 study subjects (≥40 years old) with cataract or age-related macular degeneration based on ophthalmic examination results during the 5th Korean National Health and Nutrition Examination Survey conducted between 2010 and 2012...
August 26, 2017: Korean Journal of Ophthalmology: KJO
https://www.readbyqxmd.com/read/29021717/enhanced-detection-of-sub-retinal-pigment-epithelial-cell-layer-deposits-in-human-and-murine-tissue-imaging-zinc-as-a-biomarker-for-age-related-macular-degeneration-an-american-ophthalmological-society-thesis
#17
Frederik J G M van Kuijk, Scott W McPherson, Heidi Roehrich
PURPOSE: Understanding the apparent paradoxical role of zinc in the pathogenesis and prevention of age-related macular degeneration (AMD) has been limited by the lack of animal models for its detection in sub-retinal epithelial deposits (drusen), a definitive early hallmark of AMD. In-vitro studies using Zinpyr-1 showed drusen contained high levels of zinc, but the probe was not suitable for in-vivo studies. This study compares Zinpyr-1 to ZPP1, a new fluorescein-based probe for zinc, to assess the potential of ZPP1 for in-vivo detection of zinc in drusen...
August 2017: Transactions of the American Ophthalmological Society
https://www.readbyqxmd.com/read/29020433/the-impact-of-switching-anti-vascular-endothelial-growth-factor-therapy-in-the-management-of-exudative-age-related-macular-degeneration
#18
Karen Jhi Wen Chia, Dinesh Visva Gunasekeran, Augustinus Laude
Switching of anti-vascular endothelial growth factor (VEGF) therapy in the management of poorly responsive exudative age-related macular degeneration (AMD) has had suggested benefits in individual reports that have yet to be consolidated. In this retrospective review, 24 studies published between 2009 and 2014 were identified. Reasons for switching included tachyphylaxis, health insurance coverage, cost issues, and nonresponse or inadequate response. Nine studies had data that could be used for comparison between studies...
October 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/29019023/challenges-associated-with-estimating-utility-in-wet-age-related-macular-degeneration-a-novel-regression-analysis-to-capture-the-bilateral-nature-of-the-disease
#19
Robert Hodgson, Timothy Reason, David Trueman, Rose Wickstead, Jeanette Kusel, Adam Jasilek, Lindsay Claxton, Matthew Taylor, Ruth Pulikottil-Jacob
INTRODUCTION: The estimation of utility values for the economic evaluation of therapies for wet age-related macular degeneration (AMD) is a particular challenge. Previous economic models in wet AMD have been criticized for failing to capture the bilateral nature of wet AMD by modelling visual acuity (VA) and utility values associated with the better-seeing eye only. METHODS: Here we present a de novo regression analysis using generalized estimating equations (GEE) applied to a previous dataset of time trade-off (TTO)-derived utility values from a sample of the UK population that wore contact lenses to simulate visual deterioration in wet AMD...
October 10, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/29017506/mortality-in-patients-treated-with-intravitreal-bevacizumab-for-age-related-macular-degeneration
#20
Joel Hanhart, Doron S Comaneshter, Yossi Freier Dror, Shlomo Vinker
BACKGROUND: The aim of this study is to analyze mortality in patients treated with bevacizumab for wet AMD. METHODS: We conducted a retrospective case-control study between patients who received intravitreal injections of bevacizumab as the sole treatment for exudative AMD between September 2008 and October 2014 (n = 5385) and age and gender matched controls (n = 10,756). All individuals included in the study were reviewed for sociodemographic data and comorbidities...
October 10, 2017: BMC Ophthalmology
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