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age-related macular degeneration

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https://www.readbyqxmd.com/read/29236343/relationship-between-reticular-pseudodrusen-and-choroidal-thickness-in-intermediate-age-related-macular-degeneration
#1
Chi Yun Doreen Ho, Jia Jia Lek, Khin Zaw Aung, Myra B McGuinness, Chi D Luu, Robyn H Guymer
IMPORTANCE: Reticular pseudodrusen (RPD) is strongly associated with late age-related macular degeneration (AMD) but their etiology remains unknown. RPD have been associated with reduced choroidal thickness but most studies are limited by small sample size and varying severity of AMD. BACKGROUND: To investigate the relationship between choroidal thickness (ChT) and RPD in eyes with intermediate AMD (iAMD), controlling for variables known to influence ChT. DESIGN: Retrospective cohort study PARTICIPANTS: Participants were recruited from Centre for Eye Research Australia...
December 13, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/29234888/correction-to-plasma-levels-of-hypoxia-regulated-factors-in-patients-with-age-related-macular-degeneration
#2
Ioanna Zygoula, Christian Schori, Christian Grimm, Daniel Barthelmes
The original publication of this paper contains mistakes due to incorrect order of first and last names.
December 12, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29234807/development-and-validation-of-a-deep-learning-system-for-diabetic-retinopathy-and-related-eye-diseases-using-retinal-images-from-multiethnic-populations-with-diabetes
#3
Daniel Shu Wei Ting, Carol Yim-Lui Cheung, Gilbert Lim, Gavin Siew Wei Tan, Nguyen D Quang, Alfred Gan, Haslina Hamzah, Renata Garcia-Franco, Ian Yew San Yeo, Shu Yen Lee, Edmund Yick Mun Wong, Charumathi Sabanayagam, Mani Baskaran, Farah Ibrahim, Ngiap Chuan Tan, Eric A Finkelstein, Ecosse L Lamoureux, Ian Y Wong, Neil M Bressler, Sobha Sivaprasad, Rohit Varma, Jost B Jonas, Ming Guang He, Ching-Yu Cheng, Gemmy Chui Ming Cheung, Tin Aung, Wynne Hsu, Mong Li Lee, Tien Yin Wong
Importance: A deep learning system (DLS) is a machine learning technology with potential for screening diabetic retinopathy and related eye diseases. Objective: To evaluate the performance of a DLS in detecting referable diabetic retinopathy, vision-threatening diabetic retinopathy, possible glaucoma, and age-related macular degeneration (AMD) in community and clinic-based multiethnic populations with diabetes. Design, Setting, and Participants: Diagnostic performance of a DLS for diabetic retinopathy and related eye diseases was evaluated using 494 661 retinal images...
December 12, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29234687/delivery-of-cr2-fh-using-aav-vector-therapy-as-treatment-strategy-in-the-mouse-model-of-choroidal-neovascularization
#4
Gloriane Schnabolk, Nathaniel Parsons, Elisabeth Obert, Balasubramaniam Annamalai, Cecile Nasarre, Stephen Tomlinson, Alfred S Lewin, Bärbel Rohrer
Complement activation plays a significant role in age-related macular degeneration (AMD) pathogenesis, and polymorphisms interfering with factor H (fH) function, a complement alternative pathway (AP) inhibitor, are associated with increased AMD risk. We have previously validated an AP inhibitor, a fusion protein consisting of a complement receptor 2 fragment linked to the inhibitory domain of fH (CR2-fH) as an efficacious treatment for choroidal neovascularization (CNV) when delivered intravenously. Here we tested an alternative approach of AAV-mediated delivery (AAV5-VMD2-CR2-fH or AAV5-VMD2-mCherry) using subretinal delivery in C57BL/6J mice...
June 15, 2018: Molecular Therapy. Methods & Clinical Development
https://www.readbyqxmd.com/read/29234364/eghb010-a-standardized-extract-of-paeoniae-radix-and-glycyrrhizae-radix-inhibits-vegf-induced-tube-formation-in-vitro-and-retinal-vascular-leakage-and-choroidal-neovascularization-in-vivo
#5
Eunsoo Jung, Wookwon Jung, Su-Bin Park, Chan-Sik Kim, Jin Sook Kim, Junghyun Kim
EGHB010 is a hot water extract of the rhizome mixture of Paeonia lactiflora Pallas and Glycyrrhiza uralensis Fisch. Choroidal neovascularization (CNV) and vascular leakage are the common pathophysiologies of age-related macular degeneration. In this study, we aimed to evaluate the effect of EGHB010 on retinal vascular leakage and laser-induced CNV in a rat model. Vascular endothelial growth factor- (VEGF-) induced tube formation was assayed in human retinal microvascular endothelial cells. Intravitreal VEGF-induced blood-retinal barrier breakdown was assayed in Sprague-Dawley rats...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29232758/-time-course-of-changes-in-visual-acuity-after-a-single-injection-of-aflibercept-or-ranibizumab-in-neovascular-age-related-macular-degeneration-analysis-of-aggregated-real-life-data
#6
Robert G H Wilke, Robert Patrick Finger, Helmut G Sachs
Background Treatment of neovascular age-related macular degeneration (nvAMD) under real life conditions may differ from controlled prospective trials with respect to the number of injections and long term preservation of visual acuity. In many instances, intervals for controls and re-injection cannot be maintained as frequently as required. This case series examines actual intervals for control and re-injection visits, in order to estimate how prolonged intervals have an impact on momentary visual acuity and how long term visual outcome is affected...
December 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29232336/comparison-among-different-diagnostic-methods-in-the-study-of-type-and-activity-of-choroidal-neovascular-membranes-in-age-related-macular-degeneration
#7
Vittoria Ravera, Andrea Giani, Marco Pellegrini, Marta Oldani, Alessandro Invernizzi, Elisa Carini, Mario Cigada, Ferdinando Bottoni, Giovanni Staurenghi
PURPOSE: To determine interobserver and intraobserver agreement in classifying the subtypes of choroidal neovascularization (CNV) and the decision of retreatment in patients affected by exudative age-related macular degeneration. Different imaging techniques were evaluated individually and compared with multiimaging. METHODS: Fifty-two patients with naive CNV in age-related macular degeneration were evaluated after 3 monthly intravitreal injections of ranibizumab...
December 8, 2017: Retina
https://www.readbyqxmd.com/read/29232334/intravitreal-ziv-aflibercept-for-neovascular-age-related-macular-degeneration-52-week-results
#8
João R de Oliveira Dias, Gabriel Costa de Andrade, Vinicius F Kniggendorf, Eduardo A Novais, Vítor K L Takahashi, André Maia, Carsten Meyer, Sung E S Watanabe, Michel E Farah, Eduardo B Rodrigues
PURPOSE: To evaluate the 52-week safety and efficacy of intravitreal ziv-aflibercept in patients with neovascular age-related macular degeneration. METHODS: All patients received three monthly intravitreal injections of 0.05 mL of ziv-aflibercept (1.25 mg) followed by a pro re nata regimen. The best-corrected visual acuity and spectral domain optical coherence tomography were obtained at baseline and monthly. Full-field and multifocal electroretinograms were obtained at baseline and 4, 13, 26, and 52 weeks...
December 11, 2017: Retina
https://www.readbyqxmd.com/read/29229653/investigation-of-time-to-first-presentation-and-extrahospital-factors-in-the-treatment-of-neovascular-age-related-macular-degeneration-a-retrospective-cross-sectional-study
#9
Peng Yong Sim, Sonul Gajree, Baljean Dhillon, Shyamanga Borooah
OBJECTIVES: To assess the time from symptom onset to treatment for neovascular age-related macular degeneration (nvAMD) and to measure the awareness of AMD in Southeast Scotland. DESIGN: Retrospective cross-sectional study. SETTING: Secondary care, Southeast of Scotland. METHODS: Patients treated with intravitreal therapy (IVT) for nvAMD in Southeast Scotland between 2013 and 2015 were identified using a treatment register...
December 10, 2017: BMJ Open
https://www.readbyqxmd.com/read/29229445/optical-coherence-tomography-angiography
#10
REVIEW
Richard F Spaide, James G Fujimoto, Nadia K Waheed, Srinivas R Sadda, Giovanni Staurenghi
Optical coherence tomography (OCT) was one of the biggest advances in ophthalmic imaging. Building on that platform, OCT angiography (OCTA) provides depth resolved images of blood flow in the retina and choroid with levels of detailed far exceeding that obtained with older forms of imaging. This new modality is challenging because of the need for new equipment and processing techniques, current limitations of imaging capability, and rapid advancements in both imaging and in our understanding of the imaging and applicable pathophysiology of the retina and choroid, and the requirement for understanding the origins of image artifacts...
December 8, 2017: Progress in Retinal and Eye Research
https://www.readbyqxmd.com/read/29229444/neural-control-of-choroidal-blood-flow
#11
REVIEW
Anton Reiner, Malinda E C Fitzgerald, Nobel Del Mar, Chunyan Li
The choroid is richly innervated by parasympathetic, sympathetic and trigeminal sensory nerve fibers that regulate choroidal blood flow in birds and mammals, and presumably other vertebrate classes as well. The parasympathetic innervation has been shown to vasodilate and increase choroidal blood flow, the sympathetic input has been shown to vasoconstrict and decrease choroidal blood flow, and the sensory input has been shown to both convey pain and thermal information centrally and act locally to vasodilate and increase choroidal blood flow...
December 8, 2017: Progress in Retinal and Eye Research
https://www.readbyqxmd.com/read/29227822/automated-retinal-health-diagnosis-using-pyramid-histogram-of-visual-words-and-fisher-vector-techniques
#12
Joel E W Koh, Eddie Y K Ng, Sulatha V Bhandary, Yuki Hagiwara, Augustinus Laude, U Rajendra Acharya
Untreated age-related macular degeneration (AMD), diabetic retinopathy (DR), and glaucoma may lead to irreversible vision loss. Hence, it is essential to have regular eye screening to detect these eye diseases at an early stage and to offer treatment where appropriate. One of the simplest, non-invasive and cost-effective techniques to screen the eyes is by using fundus photo imaging. But, the manual evaluation of fundus images is tedious and challenging. Further, the diagnosis made by ophthalmologists may be subjective...
December 5, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29225722/cellular-senescence-in-age-related-macular-degeneration-can-autophagy-and-dna-damage-response-play-a-role
#13
REVIEW
Janusz Blasiak, Malgorzata Piechota, Elzbieta Pawlowska, Magdalena Szatkowska, Ewa Sikora, Kai Kaarniranta
Age-related macular degeneration (AMD) is the main reason of blindness in developed countries. Aging is the main AMD risk factor. Oxidative stress, inflammation and some genetic factors play a role in AMD pathogenesis. AMD is associated with the degradation of retinal pigment epithelium (RPE) cells, photoreceptors, and choriocapillaris. Lost RPE cells in the central retina can be replaced by their peripheral counterparts. However, if they are senescent, degenerated regions in the macula cannot be regenerated...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29225458/antiangiogenic-effect-of-dasatinib-in-murine-models-of-oxygen-induced-retinopathy-and-laser-induced-choroidal-neovascularization
#14
Songyi Seo, Wonhee Suh
Purpose: Vascular endothelial growth factor (VEGF) is a principal mediator of pathological ocular neovascularization, which is the leading cause of blindness in various ocular diseases. As Src, a non-receptor tyrosine kinase, has been implicated as one of the major signaling molecules in VEGF-mediated neovascularization, the present study aimed to investigate whether dasatinib, a potent Src kinase inhibitor, could suppress pathological ocular neovascularization in murine models of oxygen-induced retinopathy (OIR) and choroidal neovascularization (CNV)...
2017: Molecular Vision
https://www.readbyqxmd.com/read/29225397/concurrent-oct-imaging-of-stimulus-evoked-retinal-neural-activation-and-hemodynamic-responses
#15
Taeyoon Son, Benquan Wang, Yiming Lu, Yanjun Chen, Dingcai Cao, Xincheng Yao
It is well established that major retinal diseases involve distortions of the retinal neural physiology and blood vascular structures. However, the details of distortions in retinal neurovascular coupling associated with major eye diseases are not well understood. In this study, a multi-modal optical coherence tomography (OCT) imaging system was developed to enable concurrent imaging of retinal neural activity and vascular hemodynamics. Flicker light stimulation was applied to mouse retinas to evoke retinal neural responses and hemodynamic changes...
2017: Proceedings of SPIE
https://www.readbyqxmd.com/read/29224928/association-of-rare-predicted-loss-of-function-variants-in-cellular-pathways-with-sub-phenotypes-in-age-related-macular-degeneration
#16
Alexandra Pietraszkiewicz, Freekje van Asten, Alan Kwong, Rinki Ratnapriya, Goncalo Abecasis, Anand Swaroop, Emily Y Chew
PURPOSE: To investigate the association of rare predicted loss-of-function (pLoF) variants within age-related macular degeneration (AMD) risk loci and AMD sub-phenotypes. DESIGN: Case-control study. PARTICIPANTS: Participants of AREDS, AREDS2, and Michigan Genomics Initiative. METHODS: Whole genome sequencing data were analyzed for rare pLoF variants (frequency <0.1%) in the regions of previously identified 52 independent risk variants known to be associated with AMD...
December 7, 2017: Ophthalmology
https://www.readbyqxmd.com/read/29224926/fully-automated-detection-and-quantification-of-macular-fluid-in-oct-using-deep-learning
#17
Thomas Schlegl, Sebastian M Waldstein, Hrvoje Bogunovic, Franz Endstraßer, Amir Sadeghipour, Ana-Maria Philip, Dominika Podkowinski, Bianca S Gerendas, Georg Langs, Ursula Schmidt-Erfurth
PURPOSE: Development and validation of a fully automated method to detect and quantify macular fluid in conventional OCT images. DESIGN: Development of a diagnostic modality. PARTICIPANTS: The clinical dataset for fluid detection consisted of 1200 OCT volumes of patients with neovascular age-related macular degeneration (AMD, n = 400), diabetic macular edema (DME, n = 400), or retinal vein occlusion (RVO, n = 400) acquired with Zeiss Cirrus (Carl Zeiss Meditec, Dublin, CA) (n = 600) or Heidelberg Spectralis (Heidelberg Engineering, Heidelberg, Germany) (n = 600) OCT devices...
December 8, 2017: Ophthalmology
https://www.readbyqxmd.com/read/29224686/estimating-public-and-patient-savings-from-basic-research-a-study-of-optical-coherence-tomography-in-managing-antiangiogenic-therapy
#18
Matthew A Windsor, Sissi J J Sun, Kevin D Frick, Eric A Swanson, Philip J Rosenfeld, David Huang
PURPOSE: To compare patient and Medicare savings from the use of optical coherence tomography (OCT) in guiding therapy for neovascular age-related macular degeneration (nvAMD) to the research investments made in developing OCT by the National Institutes of Health (NIH) and the National Science Foundation (NSF). DESIGN: Observational cohort study. METHODS: Main outcome measures were spending by Medicare as tracked by Current Procedural Terminology codes on intravitreal injections (67028), retinal OCT imaging (92134), and anti-vascular endothelial growth factor (anti-VEGF) treatment-specific J-codes (J0178, J2778, J9035, J3490, and J3590)...
December 1, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29224056/a-5-year-multicenter-prospective-cohort-study-on-the-long-term-visual-prognosis-and-predictive-factors-for-visual-outcome-in-japanese-patients-with-age-related-macular-degeneration-the-amd2000-study
#19
Yumiko Akagi-Kurashige, Akitaka Tsujikawa, Mitsuko Yuzawa, Tatsuro Ishibashi, Hideo Nakanishi, Eiji Nakatani, Satoshi Teramukai, Masanori Fukushima, Nagahisa Yoshimura
PURPOSE: In this study (AMD2000), we aimed to determine the visual prognosis of Japanese patients with age-related macular degeneration (AMD). METHODS: This was a multicenter prospective observational cohort study. In total, 460 patients with AMD were recruited from April 2006 to March 2009 from 18 clinical trial sites in Japan. They were followed up for 5 years, as they continued to receive medical treatment. RESULTS: Of the 409 study eyes followed up for at least 1 year, 243 eyes (59...
December 9, 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29223681/language-processing-in-age-related-macular-degeneration-associated-with-unique-functional-connectivity-signatures-in-the-right-hemisphere
#20
Jie Zhuang, David J Madden, Xuan Duong-Fernandez, Nan-Kuei Chen, Scott W Cousins, Guy G Potter, Michele T Diaz, Heather E Whitson
Age-related macular degeneration (AMD) is a retinal disease associated with significant vision loss among older adults. Previous large-scale behavioral studies indicate that people with AMD are at increased risk of cognitive deficits in language processing, particularly in verbal fluency tasks. The neural underpinnings of any relationship between AMD and higher cognitive functions, such as language processing, remain unclear. This study aims to address this issue using independent component analysis of spontaneous brain activity at rest...
November 14, 2017: Neurobiology of Aging
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