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https://www.readbyqxmd.com/read/28742138/long-term-prognostic-factors-of-chronic-central-serous-chorioretinopathy-after-half-dose-photodynamic-therapy-a-3-year-follow-up-study
#1
Fuminori Haga, Ruka Maruko, Chiaki Sato, Keiko Kataoka, Yasuki Ito, Hiroko Terasaki
PURPOSE: To evaluate the long-term efficacy and factors involved in the recurrence and persistence of subretinal fluid (SRF) after half-dose photodynamic therapy (PDT) for chronic central serous chorioretinopathy (CSC). METHODS: In this retrospective observational case series, 79 eyes (73 patients) with chronic CSC were treated with half-dose PDT and followed up for at least 3 years. They were divided into successful (64 eyes) and unsuccessful (15 eyes) groups based on SRF absorption and disease recurrence after one PDT session...
2017: PloS One
https://www.readbyqxmd.com/read/28728183/early-focal-laser-photocoagulation-in-acute-central-serous-chorioretinopathy-a-prospective-randomized-study
#2
Vikas Ambiya, Mitali Khodani, Abhilash Goud, Raja Narayanan, Mudit Tyagi, Padmaja Kumari Rani, Jay Chhablani
BACKGROUND AND OBJECTIVE: To evaluate the role of early focal laser photocoagulation in acute central serous chorioretinopathy (CSC). PATIENTS AND METHODS: A total of 58 eyes with acute naïve CSC (less than 2 months' duration) with focal leak on fundus fluorescein angiography (FFA) were randomized into either a laser or a sham laser group. Eyes with chronic CSC and subfoveal leak were excluded. Visual acuity assessment, microperimetry, optical coherence tomography, and FFA were done at baseline, 1 month (minus FFA), 3 months, and 6 months after treatment...
July 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28725290/the-discovery-of-the-flammer-syndrome-a-historical-and-personal-perspective
#3
REVIEW
Josef Flammer, Katarzyna Konieczka
This review describes the clinical and basic research that led to the description of Flammer syndrome. It is narrated from a personal perspective. This research was initiated by the observation of an increased long-term fluctuation of visual fields in a subgroup of glaucoma patients. As these patients had strikingly cold hands, peripheral blood flow was tested with a capillary microscopy, and vasospastic syndrome (VS) was diagnosed. Further studies on these patients revealed frequently weakened autoregulation of ocular blood flow and increased flow resistivity in retroocular vessels...
June 2017: EPMA Journal
https://www.readbyqxmd.com/read/28723851/indocyanine-green-angiography-of-pachychoroid-pigment-epitheliopathy
#4
M Giray Ersoz, Serra Arf, Mumin Hocaoglu, Isil Sayman Muslubas, Murat Karacorlu
PURPOSE: To compare choroidal hyperpermeability and vessel density between eyes with central serous chorioretinopathy (CSC), those with pachychoroid pigment epitheliopathy (PPE) and those with uncomplicated pachychoroid (UCP). METHODS: We retrospectively reviewed indocyanine green angiography images of 60 patients with unilateral active CSC who had PPE (36 eyes) or UCP (24 eyes) in their fellow eyes. We used color thresholding of indocyanine green angiography images to determine choroidal vessel density...
July 18, 2017: Retina
https://www.readbyqxmd.com/read/28712034/recurrence-of-acute-lymphoblastic-leukemia-manifesting-as-serous-retinal-detachments-and-optic-disc-swelling
#5
Ozge Yabas Kiziloglu, Mert Mestanoglu, Ozgun Melike Totuk Gedar, Cafer Adiguzel, Okan Toygar
PURPOSE: The aim of this case report is to describe a patient with acute lymphoblastic leukemia (ALL) who developed bilateral serous retinal detachments and unilateral optic disc swelling. METHODS: A 23-year-old woman with ALL presented to the ophthalmology clinic with bilateral subacute visual loss. RESULTS: Ophthalmologic examination revealed bilateral serous retinal detachments and unilateral optic disc swelling. Magnetic resonance imaging for differential diagnosis was inconclusive; however, cerebrospinal fluid sampling demonstrated leukemic involvement of the central nervous system...
July 15, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28709702/clinical-and-morphologic-characteristics-of-mek-inhibitor-associated-retinopathy-differences-from-central-serous-chorioretinopathy
#6
Jasmine H Francis, Larissa A Habib, David H Abramson, Lawrence A Yannuzzi, Murk Heinemann, Mrinal M Gounder, Rachel N Grisham, Michael A Postow, Alexander N Shoushtari, Ping Chi, Neil H Segal, Rona Yaeger, Alan L Ho, Paul B Chapman, Federica Catalanotti
PURPOSE: To investigate the clinical and morphologic characteristics of serous retinal disturbances in patients taking mitogen-activated protein kinase kinase (MEK) inhibitors. PARTICIPANTS: A total of 313 fluid foci in 50 eyes of 25 patients receiving MEK inhibitors for treatment of their metastatic cancer, who had evidence of serous retinal detachments confirmed by optical coherence tomography (OCT). DESIGN: Single-center, retrospective cohort study...
July 12, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28704254/efficacy-and-safety-of-ranibizumab-for-the-treatment-of-choroidal-neovascularization-due-to-uncommon-cause-twelve-month-results-of-the-minerva-study
#7
Timothy Y Y Lai, Giovanni Staurenghi, Paolo Lanzetta, Frank G Holz, Shiao Hui Melissa Liew, Sabine Desset-Brethes, Harry Staines, Philip G Hykin
PURPOSE: To evaluate the efficacy and safety of ranibizumab 0.5 mg in adult patients with choroidal neovascularization because of an uncommon cause enrolled in the 12-month MINERVA study. METHODS: In this Phase III, double-masked study, adult (≥18 years) patients (N = 178) were randomized 2:1 to receive either ranibizumab (n = 119) or sham (n = 59) at baseline and, if needed, at Month 1 and open-label individualized ranibizumab from Month 2. Best-corrected visual acuity change from baseline to Month 2 (primary endpoint) and Month 12, treatment exposure, and safety over 12 months were reported...
July 12, 2017: Retina
https://www.readbyqxmd.com/read/28699928/anti-vegf-therapy-versus-photodynamic-therapy-in-the-treatment-of-choroidal-neovascularization-secondary-to-central-serous-chorioretinopathy
#8
Enrico Peiretti, Giulia Caminiti, Rita Serra, Lea Querques, Riccardo Pertile, Giuseppe Querques
PURPOSE: To evaluate the efficacy of photodynamic therapy (PDT) compared with intravitreal vascular endothelial growth factor (VEGF) inhibitors alone or combined with PDT in the treatment of choroidal neovascularization (CNV) secondary to chronic central serous chorioretinopathy (CSCR). METHODS: Retrospective study of a consecutive series of 34 white patients (34 eyes) with angiographic evidence of choroidal neovascularization secondary to chronic central serous chorioretinopathy, divided into two groups followed for at least 12 months: 16 were treated with full fluence PDT (PDT group) and 18 with vascular endothelial growth factor inhibitors (intravitreal [IVT] group)...
July 7, 2017: Retina
https://www.readbyqxmd.com/read/28674835/photodynamic-therapy-in-chronic-central-serous-chorioretinopathy-with-subretinal-fluid-outside-the-fovea
#9
Elon H C van Dijk, Greet Dijkman, Camiel J F Boon
PURPOSE: To assess the efficacy of photodynamic therapy (PDT) in patients with chronic central serous chorioretinopathy (cCSC), in whom subretinal fluid (SRF) was solely present outside the foveal area. METHODS: In this retrospective study, 16 eyes of 15 cCSC patients who received half-dose PDT because of notable subjective visual complaints due to the presence of extrafoveal SRF, were included. An ophthalmic examination was performed before treatment, including Early Treatment Diabetic Retinopathy Study best-corrected visual acuity measurement, applanation tonometry, slit-lamp examination, and indirect ophthalmoscopy, followed by multimodal imaging, including fundus photography, fundus autofluorescence, spectral-domain optical coherence tomography (OCT), enhanced-depth imaging OCT of the choroid, fluorescein angiography, and indocyanine green angiography...
July 3, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28673727/central-serous-chorioretinopathy-and-glucocorticoids-an-update-on-evidence-for-association
#10
REVIEW
Benjamin P Nicholson, Elizabeth Atchison, Amrou Ali Idris, Sophie J Bakri
Central serous chorioretinopathy (CSC) is a common idiopathic retinal disease characterized by central vision loss from serous detachment of the neurosensory retina, serous pigment epithelial detachments, and leakage of fluid through the retinal pigment epithelium into the sub-retinal space. The concept of an association between exogenous glucocorticoid use and CSC is widely accepted among ophthalmologists. Here we review the evidence for and against such an association. This evidence includes two large, case-control studies that found strong associations, and a smaller, population-based study that found no association...
June 30, 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28671968/systemic-complement-activation-in-central-serous-chorioretinopathy
#11
Elon H C van Dijk, Roula Tsonaka, Ngaisah Klar-Mohamad, Diana Wouters, Aiko P J de Vries, Eiko K de Jong, Cees van Kooten, Camiel J F Boon
PURPOSE: A clear link between several variants in genes involved in the complement system and chronic central serous chorioretinopathy (CSC) has been described. In age-related macular degeneration, a disease that shows clinical features that overlap with CSC, both genetic risk factors and systemic activation of the complement system have previously been found. In this case-control study, we assessed whether there is evidence of either systemic activation or inhibition of the complement system in patients with chronic CSC...
2017: PloS One
https://www.readbyqxmd.com/read/28653813/eplerenone-for-chronic-central-serous-chorioretinopathy-a-randomized-controlled-prospective-study
#12
Roy Schwartz, Zohar Habot-Wilner, Michael R Martinez, Amir Nutman, Dafna Goldenberg, Shai Cohen, Shiri Shulman, Hanan Guzner-Gur, Anat Loewenstein, Michaella Goldstein
PURPOSE: To evaluate the efficacy and safety of eplerenone for chronic nonresolving central serous chorioretinopathy (CSC). METHODS: Prospective, double-blind, randomized placebo-controlled study. Nineteen eyes of 17 patients with persistent subretinal fluid (SRF) due to CSC were enrolled and randomized to receive eplerenone 50 mg/day or placebo for 3 months, followed by a 3-month follow-up. The main outcome measure was change in SRF from baseline to 3 months of treatment...
June 27, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28646440/a-comparison-of-three-different-intravitreal-treatment-modalities-of-macular-edema-due-to-branch-retinal-vein-occlusion
#13
Havva Erdogan Kaldırım, Serpil Yazgan
PURPOSE: To compare the efficacy of intravitreal injection of ranibizumab, dexamethasone implant and aflibercept for the management of macular edema (ME) related to branch retinal vein occlusion (BRVO). METHODS: This retrospective and comparative study included 62 eyes of 62 patients with BRVO and ME. Patients received one of the following treatments: 0.5 mg ranibizumab (group 1, n = 22), 0.7 mg dexamethasone implant (group 2, n = 20) and 2 mg aflibercept (group 3, n = 20)...
June 23, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28643718/a-rare-case-of-idiopathic-parafoveal-telangiectasia-associated-with-central-serous-chorioretinopathy
#14
Nicey Roy Thomas, Rupak Roy, Kumar Saurabh, Kalpita Das
No abstract text is available yet for this article.
June 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28630787/evaluation-of-aflibercept-treatment-responses-in-eyes-with-bevacizumab-ranibizumab-resistant-wet-age-related-macular-degeneration
#15
Tuncay Topal, Taner Kar, Yıldıray Yıldırım, Sercan Koray Sağdıç, Cihan Büyükavşar, Abdullah Kaya, Ali Ayata, Murat Sönmez, Melih Hamdi Ünal
OBJECTIVES: To evaluate anatomic and functional results after switching from intravitreal bevacizumab or ranibizumab treatment to aflibercept for wet (neovascular) age-related macular degeneration. MATERIALS AND METHODS: This retrospective study included 22 eyes of 22 patients resistant to treatment with at least 6 injections of bevacizumab or ranibizumab. The first three injections had been applied monthly, the others pro re nata (PRN). Outcome measures were follow-up period, injection number, best corrected visual acuity (BCVA), central retinal thickness (CRT) and pigment epithelial detachment (PED) height...
June 2017: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28626824/atypical-chronic-central-serous-chorioretinopathy-with-cystoid-macular-edema-therapeutic-response-to-medical-and-laser-therapy
#16
Jiun L Do, Lisa C Olmos de Koo, Hossein Ameri
PURPOSE: To describe an atypical case of chronic central serous chorioretinopathy (CSCR). METHODS: A 58-year-old man with longstanding, bilateral visual impairment was self-referred for a second opinion. RESULTS: Findings by direct ophthalmoscopy, optical coherence tomography, fluorescein angiography, and fundus autofluorescence (FAF) were suggestive of atypical, chronic CSCR. Treatment with oral anti-mineralocorticoids resulted in moderate improvement, and photodynamic therapy (PDT) had minimal effect...
June 2017: Journal of Current Ophthalmology
https://www.readbyqxmd.com/read/28626419/shallow-anterior-chamber-in-a-severe-case-of-unilateral-acute-central-serous-retinal-detachment
#17
Ahmet Colakoglu, Banu Cosar
BACKGROUND: Atypical serous chorioretinopathy can present with symptoms similar to those of other pachychoroid diseases; however, a proper differential diagnosis will prevent unnecessary intensive treatments. To this end, we report on the shallowness of anterior chamber and transitory anterior vitreous cells in a patient with atypical severe serous retinal detachment. CASE PRESENTATION: A 42-year-old woman presented with unilateral visual loss accompanied by mild, vague eye pain for 4 days...
May 2017: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/28626417/spironolactone-as-an-adjunctive-treatment-in-neovascular-age-related-macular-degeneration
#18
Kapil G Kapoor, Jennifer Sim
Neovascular age-related macular degeneration (AMD) is a potentially sight-threatening condition. The current standard-of-care treatment regimen is serial intravitreal antivascular endothelial growth factor injections. While these typically have great success, they do carry exceptional treatment burden on the patient, cost burden due to their required frequency of use, and the risk of endophthalmitis, which can be devastating. This case report explores an alternative potential option as a treatment adjunct for neovascular AMD (nAMD), and identifies some of the overlap between nAMD and central serous chorioretionpathy...
May 2017: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/28616258/the-comparison-of-multimodal-imaging-findings-of-central-serous-chorioretinopathy-patients-in-regard-to-the-early-anatomically-treatment-response-to-half-fluence-photodynamic-therapy-a-retrospective-case-control-study
#19
Abdullah Ozkaya, Ruveyde Garip, Zeynep Alkin, Muhittin Taskapili
BACKGROUND: To compare the multimodal imaging findings of chronic central serous chorioretinopathy (CSC) patients who are good or poor responders to low-fluence photodynamic therapy (PDT). METHODS: Retrospective, interventional comparative study. The CSC patients who were admitted to our clinic for the first time between January 2013 and December 2015 were included in the study. Patients were treated with PDT only if they did not show any sign of resolution after at least 6 months from the initial signs of the disease...
2017: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/28600300/retinal-vessels-functionality-in-eyes-with-central-serous-chorioretinopathy
#20
Livia Tomasso, Lucia Benatti, Alessandro Rabiolo, Adriano Carnevali, Ilaria Zucchiatti, Lea Querques, Francesco Bandello, Giuseppe Querques
PURPOSE: To analyse static characteristics and dynamic functionality of retinal vessels in eyes with central serous chorioretinopathy (CSCR) by means of Dynamic Vessel Analyzer (DVA). METHODS: Patients presenting with treatment-naïve CSCR and normal subjects (controls) matched for age and sex between May 2015 and November 2015 were enrolled in the study. Participants underwent a complete ophthalmological examination, including dynamic and static retinal vessels analysis by DVA...
June 9, 2017: British Journal of Ophthalmology
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