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https://www.readbyqxmd.com/read/28924442/laser-induced-choroidal-neovascularizations-clinical-study-of-3-cases
#1
Wipada Laovirojjanakul, Thuss Sanguansak, Yosanan Yospaiboon, Supat Sinawat, Suthasinee Sinawat
BACKGROUND: We report 3 patients with laser-induced choroidal neovascularization (CNV). METHOD: Retrospective, observational case series. Medical charts and photographs were reviewed. RESULTS: Two patients with central serous chorioretinopathy who developed iatrogenic CNV after focal laser photocoagulation were treated with intravitreal ranibizumab injections. One patient with CNV secondary to thermal laser photocoagulation for diabetic macular edema was treated with photodynamic therapy (PDT)...
May 2017: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/28916367/rucaparib-maintenance-treatment-for-recurrent-ovarian-carcinoma-after-response-to-platinum-therapy-ariel3-a-randomised-double-blind-placebo-controlled-phase-3-trial
#2
Robert L Coleman, Amit M Oza, Domenica Lorusso, Carol Aghajanian, Ana Oaknin, Andrew Dean, Nicoletta Colombo, Johanne I Weberpals, Andrew Clamp, Giovanni Scambia, Alexandra Leary, Robert W Holloway, Margarita Amenedo Gancedo, Peter C Fong, Jeffrey C Goh, David M O'Malley, Deborah K Armstrong, Jesus Garcia-Donas, Elizabeth M Swisher, Anne Floquet, Gottfried E Konecny, Iain A McNeish, Clare L Scott, Terri Cameron, Lara Maloney, Jeff Isaacson, Sandra Goble, Caroline Grace, Thomas C Harding, Mitch Raponi, James Sun, Kevin K Lin, Heidi Giordano, Jonathan A Ledermann
BACKGROUND: Rucaparib, a poly(ADP-ribose) polymerase inhibitor, has anticancer activity in recurrent ovarian carcinoma harbouring a BRCA mutation or high percentage of genome-wide loss of heterozygosity. In this trial we assessed rucaparib versus placebo after response to second-line or later platinum-based chemotherapy in patients with high-grade, recurrent, platinum-sensitive ovarian carcinoma. METHODS: In this randomised, double-blind, placebo-controlled, phase 3 trial, we recruited patients from 87 hospitals and cancer centres across 11 countries...
September 12, 2017: Lancet
https://www.readbyqxmd.com/read/28892948/microperimetry-a-new-tool-for-assessing-retinal-sensitivity-in-macular-diseases
#3
Memota Laishram, Krishnagopal Srikanth, A R Rajalakshmi, Swathi Nagarajan, G Ezhumalai
INTRODUCTION: Macular disease is the leading cause of low vision in the Western world. Drusen and pigmentary irregularities are common among the rural Northern Indian population. The disease process leads to loss of central vision, metamorphopsia, macropsia or micropsia and colour vision defect. AIM: To study the retinal sensitivity changes in macular diseases using microperimetry. MATERIALS AND METHODS: It was an observational study, conducted in the Department of Ophthalmology at a rural tertiary care hospital...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28888539/variation-in-type-ii-endometrial-cancer-risk-by-hispanic-subpopulation-an-exploratory-analysis
#4
Matthew Schlumbrecht, Jordan A Baeker Bispo, Raymond R Balise, Marilyn Huang, Brian Slomovitz, Erin Kobetz
BACKGROUND: Minorities have demonstrated an increased risk for type II endometrial cancers, but no data exists about risk among minority subpopulations. Our objective was to evaluate heterogeneity in risk of type II endometrial cancer (EC) histologies across race and Hispanic sub-groups using data from Florida's statewide cancer registry (FCDS). METHODS: FCDS contains data on N=26,416 women diagnosed with EC from 2004 to 2013. Our analysis included women ≥18years of age who were classified as non-Hispanic White (NHW), non-Hispanic Black (NHB) or belonged to one of five Hispanic sub-groups, and had a histology code consistent with type I or type II EC...
September 6, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28877318/peripheral-vascular-endothelial-dysfunction-in-central-serous-chorioretinopathy
#5
Nan-Kai Wang, Yun Fu, Jung-Pan Wang, Eugene Yu-Chan Kang, An-Lun Wu, Yun-Ju Tseng, Lung-Kun Yeh, Kuan-Jen Chen, Wei-Chi Wu, Wan-Jing Ho, Chi-Chun Lai
Purpose: To explore the pathophysiology of central serous chorioretinopathy (CSC) by comparing peripheral vascular endothelium function in patients with CSC and control subjects. Methods: This study included 34 patients with CSC who attended the Department of Ophthalmology and 34 healthy age- and sex-matched healthy control subjects from a routine physical check-up population. Endothelium-dependent flow-mediated vasodilation (FMD) and endothelium-independent nitroglycerine-mediated vasodilation (NMD) were measured using high-resolution, two-dimensional ultrasonographic imaging of the brachial artery...
September 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28875245/the-relation-of-somatotypes-and-stress-response-to-central-serous-chorioretinopathy
#6
Roy Schwartz, Assaf Rozenberg, Anat Loewenstein, Michaella Goldstein
PURPOSE: To investigate a possible relationship between central serous chorioretinopathy (CSC) and specific body types and compositions (somatotypes), and to examine the cortisol stress response among CSC patients of different somatotypes in comparison with healthy subjects. METHODS: Prospective case-control study. A group of 28 patients with a previous or current diagnosis of CSC was compared with a group of 26 healthy subjects. Anthropometric measurements were used to estimate somatotype ratings in all subjects...
September 5, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28868277/extramedullary-relapse-of-acute-myelogenous-leukemia-presenting-as-a-large-serous-retinal-detachment
#7
Wesley Green, P Kumar Rao, George J Harocopos
BACKGROUND/AIMS: To describe the rare presentation of a large, unilateral, serous retinal detachment as an extramedullary manifestation of acute myelogenous leukemia (AML) recurrence without bone marrow or central nervous system involvement after more than 1 year of follow-up. METHODS: Case report. RESULTS: A teenage patient with AML, previously treated with multiple courses of systemic chemotherapy, radiation, and bone marrow transplant, presented with acute vision loss...
July 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/28868032/spironolactone-for-secondary-central-serous-chorioretinopathy-a-challenge-rechallenge-case
#8
Kapil G Kapoor, Jennifer Sim
Central serous chorioretinopathy (CSCR) is potentially sight-threatening and has been associated with corticosteroid use. CSCR secondary to steroid use can sometimes be challenging to treat, especially if continuing steroid use is medically necessary. In this case report we demonstrate the efficacy of spironolactone as an effective agent in countering CSCR secondary to steroid use. This challenge-rechallenge case may be helpful to clinicians in delineating a treatment paradigm for these patients.
May 2017: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/28860700/changes-of-outer-retinal-microstructures-after-photodynamic-therapy-for-chronic-central-serous-chorioretinopathy
#9
Kimiko Shimizu, Yohei Hashimoto, Keiko Azuma, Yoko Nomura, Ryo Obata, Hidenori Takahashi, Yasuo Yanagi
PURPOSE: To evaluate the morphological changes in retinal microstructures following modified photodynamic therapy (PDT) for chronic central serous chorioretinopathy. SUBJECTS AND METHODS: Retrospective study of 21 consecutive eyes (age, 59±8.0 years [mean ± SD]) of 21 patients with chronic central serous chorioretinopathy. Inner foveal thickness (the distance between the internal limiting membrane and external limiting membrane), photoreceptor outer segment (PROS) length at the point without serous retinal detachment and choroidal thickness were assessed with enhanced depth imaging optical coherence tomography before treatment and at 1, 3 and 6 months after modified PDT...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28845331/atypical-central-serous-chorioretinopathy
#10
Zafer Cebeci, Merih Oray, Şerife Bayraktar, İlknur Tuğal-Tutkun, Nur Kır
Bullous central serous chorioretinopathy (CSCR) is a rare variant of CSCR characterized by severe serous retinal detachment which especially involves the inferior quadrants. Corticosteroid therapy administered for systemic or ocular misdiagnoses may induce and exacerbate CSCR. The purpose of this study was to report diagnosis and treatment results of an unusual case of bullous CSCR induced by systemic and periocular corticosteroid therapy received at another medical center due to a misdiagnosis of Vogt-Koyanagi-Harada disease...
August 2017: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28834921/multiple-serous-pigment-epithelial-detachments-in-association-with-major-weight-loss-case-report-and-review-of-the-literature
#11
Valeria Kheir, Aude Ambresin, Irmela Mantel
PURPOSE: To report about two cases with bilateral multiple serous pigment epithelial detachments (sPED) following major acute weight loss. METHODS: Retrospective chart review of patients who presented with bilateral multiple sPED following acute major weight loss. The files were reviewed for their general and ophthalmic history, medication, ophthalmic status, optical coherence tomography (OCT) and enhanced depth imaging, fluorescein and indocyanine green angiography, arterial pressure, and laboratory workup...
August 21, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28832738/multimodal-assessment-of-patients-with-chronic-central-serous-chorioretinopathy
#12
Karlos Ítalo Souza Viana, Pedro M Souza Leão, Letícia Fernandes, Rubens Siqueira, Jefferson Ribeiro, Rodrigo Jorge
PURPOSE: To examine differences between fluorescein angiography (FA) and indocyanine green angiography (ICG) findings in patients with chronic central serous chorioretinopathy (CSC), comparing these with optical coherence tomography (OCT) findings. METHODS: Ten consecutive patients with chronic CSC (19 eyes; 7 men; mean age, 50.7 ± 8.4 years) underwent multimodal evaluation that included FA, ICG, and OCT (Spectralis HRA-OCT, Heidelberg Engineering, Heidelberg, Germany)...
June 2017: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/28832731/photoreceptor-assessment-using-adaptive-optics-in-resolved-central-serous-chorioretinopathy
#13
André Luiz Braga Meirelles, Murilo Wendeborn Rodrigues, Aline Fernanda Guirado, Rodrigo Jorge
We present a case of a patient with resolved central serous chorioretinopathy (CSC) in the left eye with persistent mild visual alterations 4 years after the resolution of the disease. Left eye exam revealed a best corrected visual acuity of 20/25 and a slight change of macular pigmentation. Optical coherence tomography revealed only minor irregularities in the topography of retinal pigment epithelium and Bruch's membrane. Adaptive optics (AO) optics demonstrated lower density, spacing, and changes in the photoreceptor mosaic pattern in the left eye than in the right eye, suggesting that CSC may cause damage to cones after clinical recovery...
June 2017: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/28831603/functional-and-morphological-outcome-in-patients-with-chronic-central-serous-chorioretinopathy-treated-by-subthreshold-micropulse-laser
#14
Maciej Gawęcki, Agnieszka Jaszczuk-Maciejewska, Anna Jurska-Jaśko, Andrzej Grzybowski
BACKGROUND: Chronic central serous chorioretinopathy is a serious therapeutic problem as it may lead to significant visual impairment. The aim of this retrospective study is to evaluate functional and morphological effects, as well as factors influencing visual outcome in patients treated by subthreshold micropulse laser. METHODS: Fifty-one eyes with chronic central serous chorioretinopathy lasting longer than 4 months (18 months on average) underwent up to two sessions of subtreshold micropulse laser treatment...
August 22, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28814876/neutrophil-lymphocyte-ratio-and-mean-platelet-volume-in-central-serous-chorioretinopathy
#15
Muhammet Kazim Erol, Ayse Balkarli, Ozgur Yucel, Yusuf Akar, Berna Dogan, Elcin Suren
PURPOSE: This study aimed to evaluate mean platelet volume (MPV) and neutrophil/lymphocyte ratio (NLR) values and their relationship with clinical findings in patients with central serous chorioretinopathy (CSCR). METHODS: Overall, 87 patients fulfilling inclusion criteria and 320 age- and sex-matched healthy individuals as controls were included in the study. The CSCR patients (n=87) were classified into 2 groups as acute CSCR (group 1, n=43) and chronic CSCR (group 2, n=44)...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28798899/diagnosed-a-patient-with-central-serous-chorioretinopathy-now-what-management-of-central-serous-chorioretinopathy
#16
Brian E Goldhagen, Raquel Goldhardt
PURPOSE OF REVIEW WHAT IS THE GOAL OF YOUR PAPER? WHAT QUESTIONS DID YOU SEEK TO ANSWER?: The goal of this paper is to provide a comprehensive review of the management options for central serous chorioretinopathy (CSCR). RECENT FINDINGS SUMMARIZE THE LATEST RESEARCH ON YOUR TOPIC: The majority of cases of acute CSCR may be managed with observation and cessation of corticosteroids, if possible, as well as life-style modifications including stress reduction and control of hypertension...
June 2017: Current Ophthalmology Reports
https://www.readbyqxmd.com/read/28797227/changes-in-macular-sensitivity-after-half-dose-photodynamic-therapy-for-chronic-central-serous-chorioretinopathy
#17
Alp Atik, Yijun Hu, Honghua Yu, Chun Yang, Bin Cai, Yijing Tao, Dongli Li, Yan Chen, Li Lu, Guodong Li, Ling Yuan
BACKGROUND: To evaluate the macular sensitivity changes after half-dose photodynamic therapy (PDT) for chronic central serous chorioretinopathy (CSCR). METHODS: Eighteen patients (26 eyes) with chronic CSCR were recruited in the same hospital between April 2011 and December 2012. All patients were treated with one session of half-dose PDT after complete ophthalmic examination. Macular sensitivity examination was performed at baseline and 1, 3 and 6 months post-treatment...
August 10, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28791061/visual-and-anatomical-outcomes-of-spironolactone-therapy-in-patients-with-chronic-central-serous-chorioretinopathy
#18
Khalil Ghasemi Falavarjani, Anahita Amirsardari, Abbas Habibi, Acieh Eshaghi, Shohreh Bakhti, Kaveh Abri Aghdam
PURPOSE: To evaluate the effect of spironolactone on chronic central serous chorioretinopathy (CSC). METHODS: In this prospective interventional case series, patients with chronic CSC were treated with spironolactone (25 mg daily) for at least 6 weeks. If the subretinal fluid (SRF) had not completely resolved by this time, treatment was continued, and the dosage was increased to 25 mg twice daily. Primary outcome measure was the change in maximum SRF height at the final follow-up visit, as detected by optical coherence tomography...
July 2017: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/28780617/the-association-of-helicobacter-pylori-with-choroidal-and-retinal-nerve-fiber-layer-thickness
#19
Mehmet Erol Can, Fatma Efe Kaplan, Mehmet Murat Uzel, Hasan Kiziltoprak, Mustafa Cagri Ergun, Mustafa Koc, Gülcin Simsek
PURPOSE: To investigate the effect of Helicobacter pylori (H. pylori) infection on choroidal thickness (CT) and retinal nerve fiber layer thickness (RNFLT). METHODS: The study included 25 patients with H. pylori infection and 25 healthy individuals as the control group. Helicobacter pylori patients were classified as the pre-treatment (Group 1; n: 25) and the post-treatment (Group 2; n: 25). RNFLT and CT were measured before and after treatment of H. pylori infection, using enhanced depth imaging (EDI) spectral-domain optical coherence tomography (Spectralis, Heidelberg Engineering, Heidelberg, Germany)...
August 5, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28774289/acute-uveal-effusion-during-phacoemulsification-with-preoperative-central-serous-chorioretinopathy-a-case-report
#20
Ruiqi Chang, Yu Du, Zhou Peng, Yi Lu, Xiangjia Zhu
BACKGROUND: We report a case of acute uveal effusion during phacoemulsification in an eye with preoperative chronic central serous chorioretinopathy (CSC). CASE PRESENTATION: A 55-year-old man with a history of chronic CSC for >18 months presented with bilateral opaque lenses. A preoperative ophthalmic examination showed suspected lenticonus and risky anatomical features, including a thick ciliary body, and anterior rotation of the ciliary process and iris root in both eyes...
August 3, 2017: BMC Ophthalmology
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