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https://www.readbyqxmd.com/read/29450993/near-infrared-photoimmunotherapy-with-combined-exposure-of-external-and-interstitial-light-sources
#1
Yasuhiro Maruoka, Tadanobu Nagaya, Kazuhide Sato, Fusa Ogata, Shuhei Okuyama, Peter L Choyke, Hisataka Kobayashi
Near infrared photoimmunotherapy (NIR-PIT) is a new target-cell specific cancer treatment that induces highly selective necrotic/immunogenic cell death after systemic administration of a photo-absorber antibody conjugate and subsequent NIR light exposure. However, the depth of NIR light penetration in tissue (approximately 2 centimeters) with external light sources, limits the therapeutic effects of NIR-PIT. Interstitial light exposure using cylindrical diffusing optical fibers can overcome this limitation...
February 16, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29443368/active-cone-regeneration-following-autologous-internal-limiting-membrane-chunk-transplantation-in-optic-disc-pit-associated-maculopathy
#2
Aditya Modi, Ruchir A Mehta, Naresh Kumar Yadav
This case report aims to study active cone regeneration and its functional correlation in optic disc pit maculopathy (ODPM) with a large outer macular defect treated with autologous internal limiting membrane (ILM) "chunk" transplantation. Outcome analysis was done using spectral-domain optical coherence tomography (SD-OCT), adaptive optics, and microperimetry. Visual acuity improved from counting fingers at 2 meters to 6/18 Snellen equivalent postoperatively, whereas SD-OCT demonstrated closure of outer subfoveal defect...
February 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/29434204/a-new-high-resolution-3-d-quantitative-method-for-analysing-small-morphological-features-an-example-using-a-cambrian-trilobite
#3
Jorge Esteve, Yuan-Long Zhao, Miguel Ángel Maté-González, Miguel Gómez-Heras, Jin Peng
Taphonomic processes play an important role in the preservation of small morphological features such as granulation or pits. However, the assessment of these features may face the issue of the small size of the specimens and, sometimes, the destructiveness of these analyses, which makes impossible carrying them out in singular specimen, such as holotypes or lectotypes. This paper takes a new approach to analysing small-morphological features, by using an optical surface roughness (OSR) meter to create a high-resolution three-dimensional digital-elevation model (DEM)...
February 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29432780/how-mechanical-forces-shape-the-developing-eye
#4
REVIEW
Hadi S Hosseini, Larry A Taber
In the vertebrate embryo, the eyes develop from optic vesicles that grow laterally outward from the brain tube and contact the overlying surface ectoderm. Within the region of contact, each optic vesicle and the surface ectoderm thicken to form placodes, which then invaginate to create the optic cup and lens pit, respectively. Eventually, the optic cup becomes the retina, while the lens pit closes to form the lens vesicle. Here, we review current hypotheses for the physical mechanisms that create these structures and present novel three-dimensional computer (finite-element) models to illustrate the plausibility and limitations of these hypotheses...
February 9, 2018: Progress in Biophysics and Molecular Biology
https://www.readbyqxmd.com/read/29411099/vitrectomy-for-optic-disc-pit-maculopathy-a-long-term-follow-up-study
#5
Ferdinando Bottoni, Matteo Cereda, Roberta Secondi, Sara Bochicchio, Giovanni Staurenghi
PURPOSE: To evaluate the clinical outcomes of vitrectomy with induction of posterior vitreous detachment for the treatment of optic disc pit maculopathy. METHODS: We retrospectively evaluated medical records and imaging studies of 11 consecutive patients with optic disc pit maculopathy who underwent vitrectomy at Sacco University Hospital, Milan, Italy, between October 2008 and December 2015. Induction of a posterior vitreous detachment (PVD) was the aim of our surgery...
February 6, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29339962/three-new-pax2-gene-mutations-in-patients-with-papillorenal-syndrome
#6
Alberto Galvez-Ruiz, Anthony J Lehner, Alicia Galindo-Ferreiro, Patrik Schatz
Papillorenal syndrome (PAPRS; Mendelian Inheritance in Man [MIM] 120330) is an autosomal dominant disease characterised by the presence of congenital renal and optic nerve abnormalities associated with mutations of the PAX2 gene. In this article, the authors present four patients with PAPRS who are carriers of three new PAX2 mutations, as well as another patient with a possible non-pathogenic variant of the PAX2 gene. All patients were given a full neurophthalmological examination, and all patients underwent a genetic test for PAX2...
October 2017: Neuro-ophthalmology
https://www.readbyqxmd.com/read/29304267/double-optic-disc-pit-with-glial-plugs-imaged-by-wide-field-optical-coherence-tomography
#7
Ismini Koulouri, Eric D Gaier, Dean Eliott, Demetrios G Vavvas
A rare case of a woman in her thirties with double optic disc pits involving opposing sectors is reported. Significantly decreased vision due to macular schisis was noted. Wide-field optical coherence tomography revealed distinct laminar defects and glial tufts associated with each pit. This case illustrates a rare view into the pathogenesis of optic disc pits. [Ophthalmic Surg Lasers Imaging Retina. 2018;49:52-54.].
January 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/29303140/optic-disc-coloboma-in-two-nigerian-siblings-case-report-and-review-of-literature
#8
Y O Babalola, O O Olawoye, P O Idam
We report two cases of bilateral asymmetric optic disc coloboma (ODC) in siblings. The index patient is a 9-year-old Nigerian girl with severe cognitive deficit who presented with a poor vision of 3 years' duration. She had a history of childhood febrile convulsions and delayed developmental milestones. Her visual acuity could not be assessed because she had a cognitive deficit and expressive aphasia. Ocular examination revealed a very large excavated right optic disc with only a strip of remnant neuro-retinal rim superiorly, and a smaller left optic disc with inferior disc excavation, superior wedge of the pink neuro-retinal rim as well as a temporal optic disc pit...
November 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29279660/occult-optic-disc-pit-maculopathy-in-a-glaucomatous-disc
#9
Chokkahalli Krishnappa Nagesha, Pratyusha Ganne
Optic pits are congenital defects of the optic disc. Diagnosis of optic pit maculopathy is quite challenging in the absence of a clinically visible or optical coherence tomography (OCT) proven pit. One such scenario is when there is advanced glaucomatous cupping. We present a case in which OCT helped detect optic disc pit maculopathy in a 60-year-old female.
July 2017: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/29260109/a-case-of-congenital-retinal-macrovessel-in-an-otherwise-normal-eye
#10
Margaret R Strampe, William J Wirostko, Joseph Carroll
Purpose: To present the case of a 37-year-old female with a foveal macrovessel. Observations: The patient had an incidental finding of congenital retinal macrovessel (CRM) in the left eye on optical coherence tomography (OCT). Visual acuity was normal, and slit lamp and dilated fundus examinations were otherwise unremarkable. OCT angiography (OCTA) imaging allowed for visualization of the depth profile of the vessel as well as the foveal avascular zone (FAZ). The FAZ and foveal pit were both smaller in the affected eye compared to the fellow eye...
December 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29259220/tailored-plasmon-induced-transparency-in-attenuated-total-reflection-response-in-a-metal-insulator-metal-structure
#11
Kouki Matsunaga, Yusuke Hirai, Yoichiro Neo, Takahiro Matsumoto, Makoto Tomita
We demonstrated tailored plasmon-induced transparency (PIT) in a metal (Au)-insulator (SiO2)-metal (Ag) (MIM) structure, where the Fano interference between the MIM waveguide mode and the surface plasmon polariton (SPP) resonance mode induced a transparency window in an otherwise opaque wavenumber (k) region. A series of structures with different thicknesses of the Ag layer were prepared and the attenuated total reflection (ATR) response was examined. The height and width of the transparency window, as well as the relevant k-domain dispersion, were controlled by adjusting the Ag layer thickness...
December 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29238852/combined-in-depth-3d-en-face-imaging-of-the-optic-disc-optic-disc-pits-and-optic-disc-pit-maculopathy-using-swept-source-megahertz-oct-at-1050%C3%A2-nm
#12
Josef Maertz, Jan Philip Kolb, Thomas Klein, Kathrin J Mohler, Matthias Eibl, Wolfgang Wieser, Robert Huber, Siegfried Priglinger, Armin Wolf
PURPOSE: To demonstrate papillary imaging of eyes with optic disc pits (ODP) or optic disc pit associated maculopathy (ODP-M) with ultrahigh-speed swept-source optical coherence tomography (SS-OCT) at 1.68 million A-scans/s. To generate 3D-renderings of the papillary area with 3D volume-reconstructions of the ODP and highly resolved en face images from a single densely-sampled megahertz-OCT (MHz-OCT) dataset for investigation of ODP-characteristics. METHODS: A 1...
December 14, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29229707/the-primary-role-of-flow-processing-in-the-identification-of-scene-relative-object-movement
#13
Simon K Rushton, Diederick C Niehorster, Paul A Warren, Li Li
Retinal image motion could be due to movement of the observer through space or an object relative to the scene. Optic flow, form, and change of position cues all provide information that could be used to separate out retinal motion due to object movement from retinal motion due to observer movement. In Experiment 1 we used a minimal display to examine the contribution of optic flow and form cues. Human participants indicated the direction of movement of a probe object presented against a background of radially moving pairs of dots...
December 11, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29202717/ten-years-follow-up-after-surgery-for-a-foveal-detachment-due-to-optic-disc-pit-a-case-report-of-outer-retinal-layer-healing
#14
Audrey Giocanti-Aurégan, Elige A Chbat, Christophe G H Morel, Bruno R Morin, John G Conrath, François C Devin
BACKGROUND: To report a case of complete progressive visual recovery and healing of outer retinal layers after vitrectomy for foveal detachment associated with optic disc pit. CASE PRESENTATION: Optical coherence tomography (OCT) follow-up was performed on a 15-year-old boy with deep optic disc pit and foveal detachment, before and for 10 years after vitrectomy with gas. The foveal detachment was successfully reattached with complete reapplication of the retina...
December 4, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/29192642/importance-of-optical-diagnosis-in-early-gastric-cancer-a-case-report-of-early-gastric-signet-ring-cell-carcinoma
#15
P S Akabah, S Mocan, C Molnar, D Dobru
Gastric signet ring cell carcinoma (SRCC) is a rare form of highly malignant adenocarcinoma. It is an epithelial malignancy characterized by the histologic appearance of more than 50% of cells as signet ring cells filled with mucin. The incidence of SRCC is rising,[1],[2] therefore, the diagnosis of these cancers in the early stage is important as it is the only stage that curative measures can be done. A 49-year-old female was hospitalized due to epigastric pain, postprandial bloating for 3 months. Upper gastrointestinal endoscopy with narrow band imaging (NBI) showed 1...
October 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29176525/nonhereditary-idiopathic-foveal-retinoschisis-associated-with-new-onset-proliferative-diabetic-retinopathy
#16
Alec L Amram, Clint Kellogg, Ahmed Elkeeb
PURPOSE: To present a case of idiopathic foveal retinoschisis in a patient with new-onset proliferative diabetic retinopathy. METHODS: Single case report. RESULTS: A 64-year-old African American man with Type 2 diabetes mellitus presented for a routine annual diabetic eye examination with mildly blurred vision at near and distance in the right eye. Fluorescein angiography demonstrated optic nerve leakage consistent with neovascularization of the disk but no leakage on or around the macula in the right eye...
November 22, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29164327/macular-retinoschisis-in-eyes-with-glaucomatous-optic-neuropathy-vitrectomy-and-natural-course
#17
Tadanobu Yoshikawa, Chihiro Yamanaka, Takamasa Kinoshita, Shohei Morikawa, Nahoko Ogata
PURPOSE: Our purpose was to determine the effectiveness of vitrectomy in resolving the macular retinoschisis in an eye with glaucomatous optic neuropathy and also to determine the natural course of macular retinoschisis. METHODS: This was a retrospective case series of patients who were diagnosed with macular retinoschisis and glaucomatous optic neuropathy. Fourteen eyes of 13 patients were studied. Patients with high myopia, vitreomacular traction syndrome, and the pit macular syndrome were excluded...
November 21, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29160785/scleral-pits-in-choroideremia-implications-for-retinal-gene-therapy
#18
Abdullah A Al-Qahtani, Shakoor Ba-Ali, Talal Alabduljalil, Aaron S Coyner, Rachel C Patel, Richard G Weleber, Aniz Girach, Søren K Christensen, Michael Larsen, Mark E Pennesi, Paul Yang
PURPOSE: We report a novel finding on spectral domain optical coherence tomography in patients with choroideremia, which we describe as scleral pits (SCPs). METHODS: Cross-sectional observational case series of 36 patients with choroideremia, who underwent ophthalmic examination and multimodal imaging, including optical coherence tomography of the macula. Optical coherence tomography images were reviewed for SCP, which were defined as discrete tracts of hyporeflectivity that traverse the sclera with or without the involvement of Bruch membrane, retinal pigment epithelium, and retina...
November 16, 2017: Retina
https://www.readbyqxmd.com/read/29142312/understanding-the-anticorrosive-protective-mechanisms-of-modified-epoxy-coatings-with-improved-barrier-active-and-self-healing-functionalities-eis-and-spectroscopic-techniques
#19
Demian I Njoku, Miaomiao Cui, Haigang Xiao, Baihui Shang, Ying Li
The present investigation adopted long-term in-situ electrochemical and spectroscopic approaches to study the combined active, self-healing and passive protective mechanisms of a new class of innovative anti-corrosive coatings based on epoxy doped with clay nanotubes impregnated with active species for the protection of carbon steel in 3.5% NaCl solution. The suitability of the as-received clay nanotubes to encapsulate the active agents was confirmed by different spectroscopic measurements. Tube end stopper with Ferric ion and polymer encapsulation with chitosan cross-linked with glutaraldehyde were adopted to tunnel the release of the active agents loaded into the nanotubes...
November 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29135265/evaluation-of-early-therapeutic-effects-after-near-infrared-photoimmunotherapy-nir-pit-using-luciferase-luciferin-photon-counting-and-fluorescence-imaging
#20
Yasuhiro Maruoka, Tadanobu Nagaya, Yuko Nakamura, Kazuhide Sato, Fusa Ogata, Shuhei Okuyama, Peter L Choyke, Hisataka Kobayashi
Near-infrared photoimmunotherapy (NIR-PIT) is a newly developed cancer treatment that induces highly selective immunogenic cell death. It is based on an antibody-photoabsorber conjugate (APC) that is activated by NIR light. The purpose of this study was to investigate the effects of NIR-PIT as measured by luciferase-luciferin photon-counting and fluorescence imaging. Six days after subcutaneous injection of A431-luc-GFP cells tumors formed in a xenograft mouse model. The EGFR-targeting antibody, panitumumab, was conjugated to the photoabsorber, IRDye-700DX (pan-IR700), and was intravenously administered to tumor-bearing mice...
November 22, 2017: Molecular Pharmaceutics
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