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https://www.readbyqxmd.com/read/29616625/plaque-burden-influences-accurate-classification-of-fibrous-cap-atheroma-by-in-vivo-optical-coherence-tomography-in-a-porcine-model-of-advanced-coronary-atherosclerosis
#1
Christian B Poulsen, Ryan M Pedrigi, Nilesh Pareek, Ismail D Kilic, Niels Ramsing Holm, Jacob F Bentzon, Hans Erik Bøtker, Erling Falk, Rob Krams, Ranil de Silva
AIMS: In-vivo validation of coronary optical coherence tomography (OCT) against histology and the effects of plaque burden (PB) on plaque classification remain unreported. We investigated this in a porcine model with human-like coronary atherosclerosis. METHODS AND RESULTS: Five female Yucatan D374Y-PCSK9 transgenic hypercholesterolemic mini-pigs were implanted with a coronary shear-modifying stent to induce advanced atherosclerosis. OCT frames (n=201) were obtained 34 weeks after implantation...
April 3, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29609042/the-primate-fovea-structure-function-and-development
#2
REVIEW
Andreas Bringmann, Steffen Syrbe, Katja Görner, Johannes Kacza, Mike Francke, Peter Wiedemann, Andreas Reichenbach
A fovea is a pitted invagination in the inner retinal tissue (fovea interna) that overlies an area of photoreceptors specialized for high acuity vision (fovea externa). Although the shape of the vertebrate fovea varies considerably among the species, there are two basic types. The retina of many predatory fish, reptilians, and birds possess one (or two) convexiclivate fovea(s), while the retina of higher primates contains a concaviclivate fovea. By refraction of the incoming light, the convexiclivate fovea may function as image enlarger, focus indicator, and movement detector...
March 30, 2018: Progress in Retinal and Eye Research
https://www.readbyqxmd.com/read/29567792/prevalence-of-the-optic-disc-anomalies-in-the-adult-south-indian-population
#3
Shikha Talwar Bassi, Ronnie George, Swarnali Sen, Rashima Asokan, Vijaya Lingam
PURPOSE: To determine the prevalence of congenitally abnormal disc (all anomalies) in an adult population in southern India. METHODS: Subjects aged ≥40 years (n=6013) underwent a complete ophthalmic examination. Optic disc anomalies were diagnosed according to the definitions given in the article. RESULTS: Optic disc anomalies were found in 81 eyes of 66 (1.1%, 95% CIs 0.00834 to 0.01361) patients. The prevalence of each anomaly in the descending order was peripapillary myelinated nerve fibre (0...
March 22, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29563760/colonic-lesion-characterization-in-inflammatory-bowel-disease-a-systematic-review-and-meta-analysis
#4
Richard Lord, Nicholas E Burr, Noor Mohammed, Venkataraman Subramanian
AIM: To perform a systematic review and meta-analysis for the diagnostic accuracy of in vivo lesion characterization in colonic inflammatory bowel disease (IBD), using optical imaging techniques, including virtual chromoendoscopy (VCE), dye-based chromoendoscopy (DBC), magnification endoscopy and confocal laser endomicroscopy (CLE). METHODS: We searched Medline, Embase and the Cochrane library. We performed a bivariate meta-analysis to calculate the pooled estimate sensitivities, specificities, positive and negative likelihood ratios (+LHR, -LHR), diagnostic odds ratios (DOR), and area under the SROC curve (AUSROC) for each technology group...
March 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29541404/interstitial-near-infrared-photoimmunotherapy-effective-treatment-areas-and-light-doses-needed-for-use-with-fiber-optic-diffusers
#5
Shuhei Okuyama, Tadanobu Nagaya, Kazuhide Sato, Fusa Ogata, Yasuhiro Maruoka, Peter L Choyke, Hisataka Kobayashi
Near-infrared photoimmunotherapy (NIR-PIT), a promising cancer therapy utilizing an antibody-photoabsorber conjugate (APC) and NIR light, which induces rapid necrotic cell death only in APC-bound cells. Effective NIR-PIT in mouse models has been achieved using superficial light illumination (SLI) with light emitting diodes (LEDs) or lasers, but in the clinical setting, fiber optic diffusers have been employed to deliver light to deeper tumors. However, the performance of NIR light in tissue delivered by fiber optic diffusers is poorly understood...
February 16, 2018: Oncotarget
https://www.readbyqxmd.com/read/29516049/optic-pit-maculopathy
#6
Ovidiu Musat, Stella Ioana Popescu, Corina Cristina Cernat, Ana Maria Boariu, Lucian Alexandru
This paper discusses a 32-year-old woman's case who presented a chronic decrease of visual acuity. In this case, the treatment was complex and consisted of a 25 GA vitrectomy, MLI peeling, covering the defect at the optic nerve papilla with that patch, gas endotamponade (C3F8). Abbreviations: MLI = internal limiting membrane; ODP-M = optic disc pit maculopathy.
October 2017: Romanian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29474223/inverted-internal-limiting-membrane-flap-technique-for-optic-disk-pit-maculopathy-morphologic-and-functional-analysis
#7
Giancarlo Sborgia, Nicola Recchimurzo, Luigi Sborgia, Alfredo Niro, Alessandra Sborgia, Marina Piepoli, Giovanni Alessio
PURPOSE: To analyze morphologic and functional changes after inverted internal limiting membrane-flap technique for optic disk pit maculopathy using optical coherence tomography, multifocal electroretinography, and microperimetry. METHODS: One case report. RESULTS: A 30-year-old woman presented us with decreased visual acuity (20/63) in the left eye because of retinoschisis and serous macular detachment associated with optic disk pit. Optical coherence tomography did not localize the source of intraretinal and subretinal fluid...
February 22, 2018: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29458829/unilateral-double-optic-nerve-head-pits
#8
Erin A Boese, David Huang, Shandiz Tehrani
No abstract text is available yet for this article.
March 2018: Ophthalmology
https://www.readbyqxmd.com/read/29450993/near-infrared-photoimmunotherapy-with-combined-exposure-of-external-and-interstitial-light-sources
#9
Yasuhiro Maruoka, Tadanobu Nagaya, Kazuhide Sato, Fusa Ogata, Shuhei Okuyama, Peter L Choyke, Hisataka Kobayashi
Near infrared photoimmunotherapy (NIR-PIT) is a new target-cell specific cancer treatment that induces highly selective necrotic/immunogenic cell death after systemic administration of a photo-absorber antibody conjugate and subsequent NIR light exposure. However, the depth of NIR light penetration in tissue (approximately 2 centimeters) with external light sources, limits the therapeutic effects of NIR-PIT. Interstitial light exposure using cylindrical diffusing optical fibers can overcome this limitation...
February 16, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29443368/active-cone-regeneration-following-autologous-internal-limiting-membrane-chunk-transplantation-in-optic-disc-pit-associated-maculopathy
#10
Aditya Modi, Ruchir A Mehta, Naresh Kumar Yadav
This case report aims to study active cone regeneration and its functional correlation in optic disc pit maculopathy (ODPM) with a large outer macular defect treated with autologous internal limiting membrane (ILM) "chunk" transplantation. Outcome analysis was done using spectral-domain optical coherence tomography (SD-OCT), adaptive optics, and microperimetry. Visual acuity improved from counting fingers at 2 meters to 6/18 Snellen equivalent postoperatively, whereas SD-OCT demonstrated closure of outer subfoveal defect...
February 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/29434204/a-new-high-resolution-3-d-quantitative-method-for-analysing-small-morphological-features-an-example-using-a-cambrian-trilobite
#11
Jorge Esteve, Yuan-Long Zhao, Miguel Ángel Maté-González, Miguel Gómez-Heras, Jin Peng
Taphonomic processes play an important role in the preservation of small morphological features such as granulation or pits. However, the assessment of these features may face the issue of the small size of the specimens and, sometimes, the destructiveness of these analyses, which makes impossible carrying them out in singular specimen, such as holotypes or lectotypes. This paper takes a new approach to analysing small-morphological features, by using an optical surface roughness (OSR) meter to create a high-resolution three-dimensional digital-elevation model (DEM)...
February 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29432780/how-mechanical-forces-shape-the-developing-eye
#12
REVIEW
Hadi S Hosseini, Larry A Taber
In the vertebrate embryo, the eyes develop from optic vesicles that grow laterally outward from the brain tube and contact the overlying surface ectoderm. Within the region of contact, each optic vesicle and the surface ectoderm thicken to form placodes, which then invaginate to create the optic cup and lens pit, respectively. Eventually, the optic cup becomes the retina, while the lens pit closes to form the lens vesicle. Here, we review current hypotheses for the physical mechanisms that create these structures and present novel three-dimensional computer (finite-element) models to illustrate the plausibility and limitations of these hypotheses...
February 9, 2018: Progress in Biophysics and Molecular Biology
https://www.readbyqxmd.com/read/29411099/vitrectomy-for-optic-disc-pit-maculopathy-a-long-term-follow-up-study
#13
Ferdinando Bottoni, Matteo Cereda, Roberta Secondi, Sara Bochicchio, Giovanni Staurenghi
PURPOSE: To evaluate the clinical outcomes of vitrectomy with induction of posterior vitreous detachment for the treatment of optic disc pit maculopathy. METHODS: We retrospectively evaluated medical records and imaging studies of 11 consecutive patients with optic disc pit maculopathy who underwent vitrectomy at Sacco University Hospital, Milan, Italy, between October 2008 and December 2015. Induction of a posterior vitreous detachment (PVD) was the aim of our surgery...
February 6, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29339962/three-new-pax2-gene-mutations-in-patients-with-papillorenal-syndrome
#14
Alberto Galvez-Ruiz, Anthony J Lehner, Alicia Galindo-Ferreiro, Patrik Schatz
Papillorenal syndrome (PAPRS; Mendelian Inheritance in Man [MIM] 120330) is an autosomal dominant disease characterised by the presence of congenital renal and optic nerve abnormalities associated with mutations of the PAX2 gene. In this article, the authors present four patients with PAPRS who are carriers of three new PAX2 mutations, as well as another patient with a possible non-pathogenic variant of the PAX2 gene. All patients were given a full neurophthalmological examination, and all patients underwent a genetic test for PAX2 ...
October 2017: Neuro-ophthalmology
https://www.readbyqxmd.com/read/29304267/double-optic-disc-pit-with-glial-plugs-imaged-by-wide-field-optical-coherence-tomography
#15
Ismini Koulouri, Eric D Gaier, Dean Eliott, Demetrios G Vavvas
A rare case of a woman in her thirties with double optic disc pits involving opposing sectors is reported. Significantly decreased vision due to macular schisis was noted. Wide-field optical coherence tomography revealed distinct laminar defects and glial tufts associated with each pit. This case illustrates a rare view into the pathogenesis of optic disc pits. [Ophthalmic Surg Lasers Imaging Retina. 2018;49:52-54.].
January 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/29303140/optic-disc-coloboma-in-two-nigerian-siblings-case-report-and-review-of-literature
#16
Y O Babalola, O O Olawoye, P O Idam
We report two cases of bilateral asymmetric optic disc coloboma (ODC) in siblings. The index patient is a 9-year-old Nigerian girl with severe cognitive deficit who presented with a poor vision of 3 years' duration. She had a history of childhood febrile convulsions and delayed developmental milestones. Her visual acuity could not be assessed because she had a cognitive deficit and expressive aphasia. Ocular examination revealed a very large excavated right optic disc with only a strip of remnant neuro-retinal rim superiorly, and a smaller left optic disc with inferior disc excavation, superior wedge of the pink neuro-retinal rim as well as a temporal optic disc pit...
November 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29279660/occult-optic-disc-pit-maculopathy-in-a-glaucomatous-disc
#17
Chokkahalli Krishnappa Nagesha, Pratyusha Ganne
Optic pits are congenital defects of the optic disc. Diagnosis of optic pit maculopathy is quite challenging in the absence of a clinically visible or optical coherence tomography (OCT) proven pit. One such scenario is when there is advanced glaucomatous cupping. We present a case in which OCT helped detect optic disc pit maculopathy in a 60-year-old female.
July 2017: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/29260109/a-case-of-congenital-retinal-macrovessel-in-an-otherwise-normal-eye
#18
Margaret R Strampe, William J Wirostko, Joseph Carroll
Purpose: To present the case of a 37-year-old female with a foveal macrovessel. Observations: The patient had an incidental finding of congenital retinal macrovessel (CRM) in the left eye on optical coherence tomography (OCT). Visual acuity was normal, and slit lamp and dilated fundus examinations were otherwise unremarkable. OCT angiography (OCTA) imaging allowed for visualization of the depth profile of the vessel as well as the foveal avascular zone (FAZ). The FAZ and foveal pit were both smaller in the affected eye compared to the fellow eye...
December 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29259220/tailored-plasmon-induced-transparency-in-attenuated-total-reflection-response-in-a-metal-insulator-metal-structure
#19
Kouki Matsunaga, Yusuke Hirai, Yoichiro Neo, Takahiro Matsumoto, Makoto Tomita
We demonstrated tailored plasmon-induced transparency (PIT) in a metal (Au)-insulator (SiO2 )-metal (Ag) (MIM) structure, where the Fano interference between the MIM waveguide mode and the surface plasmon polariton (SPP) resonance mode induced a transparency window in an otherwise opaque wavenumber (k) region. A series of structures with different thicknesses of the Ag layer were prepared and the attenuated total reflection (ATR) response was examined. The height and width of the transparency window, as well as the relevant k-domain dispersion, were controlled by adjusting the Ag layer thickness...
December 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29238852/combined-in-depth-3d-en-face-imaging-of-the-optic-disc-optic-disc-pits-and-optic-disc-pit-maculopathy-using-swept-source-megahertz-oct-at-1050-nm
#20
Josef Maertz, Jan Philip Kolb, Thomas Klein, Kathrin J Mohler, Matthias Eibl, Wolfgang Wieser, Robert Huber, Siegfried Priglinger, Armin Wolf
PURPOSE: To demonstrate papillary imaging of eyes with optic disc pits (ODP) or optic disc pit associated maculopathy (ODP-M) with ultrahigh-speed swept-source optical coherence tomography (SS-OCT) at 1.68 million A-scans/s. To generate 3D-renderings of the papillary area with 3D volume-reconstructions of the ODP and highly resolved en face images from a single densely-sampled megahertz-OCT (MHz-OCT) dataset for investigation of ODP-characteristics. METHODS: A 1...
February 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
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