keyword
MENU ▼
Read by QxMD icon Read
search

S. Kalkan

keyword
https://www.readbyqxmd.com/read/27821029/long-term-efficacy-of-pegylated-%C3%A4-nterferone-in-the-treatment-of-delta-hepatitis-a-single-center-experience
#1
Z M Y Kılıç, A S Köksal, I H Kalkan, N Suna, H Yıldız, S Kacar
BACKGROUND AND AIM: Currently there is no satisfactory treatment of chronic HDV. We aimed to evaluate the long term efficacy of PEG-interferones. PATIENTS METHODS: Patients who received PEG-interferone for chronic delta hepatitis during a 7-year period were retrospectively analysed. End of treatment response, virologic response at 6 months after treatment, and long term efficacy were evaluated. Predictors of treatment response were determined. RESULTS: The study group consisted of 31 patients...
July 2016: Acta Gastro-enterologica Belgica
https://www.readbyqxmd.com/read/27763329/apoptotic-mechanisms-of-n1-acetylacetone-n4-4-methoxy-salicylidene-thiosemicarbazide-chelating-with-nickel-ii-on-hl60-leukemia-cells
#2
Büşra Kaya, Belkis Atasever-Arslan, Zeynep Kalkan, Hazal Gür, Bahri Ülküseven
Thiosemicarbozone complexes that have a broad spectrum of biological activity are formed as a result of condensation reaction between thiosemicarbazide [H2N(C=S)-NH-NH2] and carbonyl-containing compounds. A new Nickel(II) complexes with N1-acetylacetone, N4-4-methoxy-salicylidene-thiosemicarbazidato ligand was synthesized and characterized. We studied the antileukemic activity of the Ni(II) thiosemicarbazone compound and assessed their potential for drug development. Specifically, the effects of this Ni(II) thiosemicarbazone compound on intracellular signal nodes and apoptotic pathways were investigated...
October 2016: General Physiology and Biophysics
https://www.readbyqxmd.com/read/27477828/unravelling-5-oxoprolinuria-pyroglutamic-aciduria-due-to-bi-allelic-oplah-mutations-20-new-mutations-in-14-families
#3
Jörn Oliver Sass, Corinne Gemperle-Britschgi, Maja Tarailo-Graovac, Nisha Patel, Melanie Walter, Albena Jordanova, Majid Alfadhel, Ivo Barić, Mahmut Çoker, Aynur Damli-Huber, Eissa Ali Faqeih, Nuria García Segarra, Michael T Geraghty, Bjørn Magne Jåtun, Sema Kalkan Uçar, Merten Kriewitz, Markus Rauchenzauner, Karmen Bilić, Ivailo Tournev, Claudia Till, Bryan Sayson, Daniel Beumer, Cynthia Xin Ye, Lin-Hua Zhang, Hilary Vallance, Fowzan S Alkuraya, Clara D M van Karnebeek
Primary 5-oxoprolinuria (pyroglutamic aciduria) is caused by a genetic defect in the γ-glutamyl cycle, affecting either glutathione synthetase or 5-oxoprolinase. While several dozens of patients with glutathione synthetase deficiency have been reported, with hemolytic anemia representing the clinical key feature, 5-oxoprolinase deficiency due to OPLAH mutations is less frequent and so far has not attracted much attention. This has prompted us to investigate the clinical phenotype as well as the underlying genotype in patients from 14 families of various ethnic backgrounds who underwent diagnostic mutation analysis following the detection of 5-oxoprolinuria...
September 2016: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/27250981/is-gastric-xanthelasma-an-alarming-endoscopic-marker-for-advanced-atrophic-gastritis-and-intestinal-metaplasia
#4
Aydın Şeref Köksal, Nuretdin Suna, İsmail Hakkı Kalkan, Ahmet Tarık Eminler, Şükran Ziyşan Sakaoğulları, Nesrin Turhan, Fatih Saygılı, Ufuk Barış Kuzu, Erkin Öztaş, Erkan Parlak
BACKGROUND/AIM: The clinical significance of gastric xanthelasmas is unknown. We conducted a case-control study in order to evaluate whether gastric xanthelasma is an indicator of advanced atrophic gastritis and intestinal metaplasia. MATERIAL AND METHOD: The study was conducted among 1400 patients who underwent elective upper endoscopy. Patients with gastric xanthelasma and atrophy and/or intestinal metaplasia constituted the study group (n = 55). The control group involved patients with only atrophic gastritis and/or intestinal metaplasia (n = 50)...
October 2016: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/27049277/protective-effects-of-thymoquinone-and-alpha-tocopherol-on-the-sciatic-nerve-and-femoral-muscle-due-to-lower-limb-ischemia-reperfusion-injury
#5
A Erkut, M C Cure, Y Kalkan, M S Balik, Y Guvercin, E Yaprak, S Yuce, I Sehitoglu, E Cure
OBJECTIVE: Thymoquinone (TQ) is an antioxidant and anti-apoptotic substance found in the Nigella sativa plant. Alpha-tocopherol (α-TP) is a potent antioxidant. We aimed to determine whether or not TQ and TP have a protective effect against lower limb ischemia-reperfusion (IR) injury of muscle and the sciatic nerve. MATERIALS AND METHODS: A single dose of TQ 25 mg/kg was given intraperitoneally to the TQ group, a single dose of α-TP 200 mg/kg was given intraperitoneally to the α-TP group...
2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/26907982/ischaemic-colitis-during-haemodialysis
#6
F Sapmaz, I H Kalkan, S Guliter
No abstract text is available yet for this article.
December 11, 2015: West Indian Medical Journal
https://www.readbyqxmd.com/read/26747008/molecular-detection-and-identification-of-leishmania-spp-in-naturally-infected-phlebotomus-tobbi-and-sergentomyia-dentata-in-a-focus-of-human-and-canine-leishmaniasis-in-western-turkey
#7
Yusuf Özbel, Mehmet Karakuş, Suha K Arserim, Şaban Orçun Kalkan, Seray Töz
Human visceral leishmaniasis (VL) is reported from 38 provinces of Turkey and dogs are accepted as main reservoir hosts. Kuşadası town, belonging to Aydın province and located in western part of Turkey, is endemic for human and canine visceral leishmaniasis caused by Leishmania infantum MON1 and MON98. In this study, phlebotomine survey was conducted to determine the vector sand fly species and to identify sand fly blood meal sources. In August and September 2012, 1027 sand fly specimens were caught using CDC light traps...
March 2016: Acta Tropica
https://www.readbyqxmd.com/read/26529305/effects-of-curcumin-on-methyl-methanesulfonate-damage-to-mouse-kidney
#8
G Cuce, S Cetinkaya, N Isitez, S Kuccukturk, M E Sozen, S Kalkan, I H Cigerci, H H Demirel
Methylmethane sulfonate (MMS) is an alkylating agent that may react with DNA and damage it. We investigated histological changes and apoptosis caused by MMS and the effects of curcumin on MMS treated mouse kidneys. Twenty-four mice were divided into four equal groups: controls injected with saline, a group injected with 40 mg/kg MMS, a group injected with 40 mg/kg MMS and given 100 mg/kg curcumin by gavage, and a group given 100 mg/kg curcumin by gavage. MMS caused congestion and vacuole formation, and elevated the apoptotic index significantly, but had no other effect on kidney tissue...
2016: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
https://www.readbyqxmd.com/read/26435238/test-retest-reliability-of-the-50-foot-timed-walk-and-30-second-chair-stand-test-in-patients-with-total-hip-arthroplasty
#9
Bayram Unver, Turhan Kahraman, Serpil Kalkan, Ertugrul Yuksel, Vasfi Karatosun, Izge Gunal
The purpose was to investigate the test-retest reliability of the 50-Foot Timed Walk (50FWT), and 30-Second Chair Stand Test (30CST) in the patients with total hip arthroplasty (THA). The study was a test-retest study. Thirty-seven patients with THA performed two trials for both the 30CTS and 50FWT on the same day with one hour interval. To assess reliability, the intra-class correlation coefficient [ICC(2,1)], standard error of measurement (SEM), the smallest real difference at the 95% confidence level (SRD95) were calculated...
September 2015: Acta Orthopaedica Belgica
https://www.readbyqxmd.com/read/26179793/biochemical-and-histopathological-effects-on-the-rat-testis-after-exposure-to-electromagnetic-field-during-fetal-period
#10
Ibrahim Sehitoglu, Levent Tumkaya, Yildiray Kalkan, Recep Bedir, Medine Cumhur Cure, Orhan Unal Zorba, Erkan Cure, Suleyman Yuce
OBJECTIVES: Electromagnetic radiation (ER) emitted from cell phones may exert a detrimental influence on human health and may affect the man reproductive system. We aimed to study the biological and morphological effects on the testes of 60-day-old male rats after ER exposure (900 MHz), which was applied continuously throughout embryogenesis. METHODS: A total of six pregnant Sprague Dawley rats were included in the study. Three pregnant rats (experimental group) were exposed to radiation from a cell phone set to talking mode for 24 hours a day for 20 days, and the other 3 pregnant rats (control group) were not to exposed to radiation...
July 2015: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/26159359/biochemical-histopathological-and-immunohistochemical-evaluation-of-the-protective-and-therapeutic-effects-of-thymoquinone-against-ischemia-and-ischemia-reperfusion-injury-in-the-rat-ovary
#11
Ülkü Mete Ural, Yeşim Bayoğlu Tekin, İbrahim Şehitoğlu, Yıldıray Kalkan, Medine Cumhur Cüre
AIM: To evaluate the antioxidant effects of thymoquinone (TQ) and to investigate the biochemical, histopathological and immunohistochemical changes in experimental rat ovarian torsion. METHODS: A total of 48 female adult rats were used in this study and randomly divided into 7 groups: (1) sham operation; (2) bilateral 3-hour ovarian ischemia; (3) 3-hour ischemia and 3-hour reperfusion; (4) and (5) rats were administered 20 and 40 mg/kg of TQ, respectively, before 0...
2016: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/26053512/spinorphin-inhibits-membrane-depolarization-and-capsaicin-induced-intracellular-calcium-signals-in-rat-primary-nociceptive-dorsal-root-ganglion-neurons-in-culture
#12
Ahmet Ayar, Mete Ozcan, Kemal Tuğrul Kuzgun, Omer Faruk Kalkan
OBJECTIVE: Spinorphin is a potential endogenous antinociceptive agent although the mechanism(s) of its analgesic effect remain unknown. We conducted this study to investigate, by considering intracellular calcium concentrations as a key signal for nociceptive transmission, the effects of spinorphin on cytoplasmic Ca(2+) ([Ca(2+)]i) transients, evoked by high-K(+) (30 mM) depolariasation or capsaicin, and to determine whether there were any differences in the effects of spinorphin among subpopulation of cultured rat dorsal root ganglion (DRG) neurons...
2015: Journal of Receptor and Signal Transduction Research
https://www.readbyqxmd.com/read/25804001/effects-of-adnexal-torsion-on-the-fallopian-tube-in-rats-a-histologic-and-immunohistochemical-study
#13
Senem Yaman Tunç, Elif Ağaçayak, Neval S Yaman, Engin Deveci, Sevgi Kalkanlı, Ali Özler
OBJECTIVE: To investigate histopathological and immunohistochemical changes in the Fallopian tube structure following ovarian torsion. STUDY DESIGN: Thirty fertile, female, adult Wistar albino rats, weighing 200-220 g, were randomly divided into 3 equal groups (n = 10): sham, torsion, and detorsion. In the torsion and detorsion groups, bilateral adnexal torsion (3-hour ischemia) was carried out. Bilateral adnexal detorsion (3-hour reperfusion) was performed in the detorsion group...
October 2014: Analytical and Quantitative Cytopathology and Histopathology
https://www.readbyqxmd.com/read/25773955/topiramate-has-protective-effect-on-renal-injury
#14
M C Cure, E Cure, L Tumkaya, Y Kalkan, I Aydin, A Kirbas, H Efe, I Sehitoglu, S Yuce
BACKGROUND: Topiramate (TPM) decreases tumor necrosis factor-alpha (TNF-α) and oxidative stress. We investigated protective effects of TPM on cell damage in kidney tissue during ischemia-reperfusion (I/R) damage. METHODS: A total of 30 male Wistar albino rats were divided into three groups: control, I/R, and I/R plus TPM (I/R+TPM). Laparotomy without I/R injury was performed in control group. After laparotomy, cross ligation of infrarenal abdominal aorta was applied for two hours in I/R groups which was followed by two hours of reperfusion...
2015: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/25712728/in-vitro-activity-of-brucella-melitensis-isolates-to-various-antimicrobials-in-turkey
#15
Affan Denk, Kutbettin Demirdag, Ahmet Kalkan, Mehmet Ozden, Burhan Cetinkaya, Suleyman S Kilic
BACKGROUND: Brucellosis is a systemic infectious disease caused by Brucella bacteria. A successful treatment requires antibiotics that can penetrate into the cell at high concentrations. The aim of this study was to assess the biotype and in vitro activity of 80 Brucella isolates obtained from blood against various antimicrobials for human brucellosis in Turkey. METHODS: Identification of the types of the species designated Brucella species was made using the polymerase chain reaction (PCR), with type-specific primers...
June 2015: Infectious Diseases
https://www.readbyqxmd.com/read/25649531/spontaneous-abdominal-esophageal-perforation-in-a-patient-with-mitochondrial-neurogastrointestinal-encephalomyopathy
#16
I H Kalkan, A Ş Köksal, S Evcimen, F Sapmaz, E Öztaş, F O Önder, S Güliter
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is an autosomal recessive multisystem disorder caused by thymidine phosphorylase deficiency. Severe denutrition is almost constant during the course of the disease which leads to severe malnutrition and requires long-term parenteral nutrition in most cases. Patients with MNGIE syndrome and chronic intestinal pseudo-obstruction have a particularly poor prognosis and they usually die around 40 years of age. Gastrointestinal perforation associated with MNGIE is extremely rare...
February 2015: Acta Clinica Belgica
https://www.readbyqxmd.com/read/25551950/behcet-disease-and-pregnancy
#17
MULTICENTER STUDY
A N C Gungor, G Kalkan, S Oguz, B Sen, P Ozoguz, Z Takci, H Sacar, F B Dogan, D Cicek
PURPOSE: Behcet disease (BD) is a multisystemic vaculitis commonly diagnosed in reproductive years. The authors aimed to investigate the relationship between BD and pregnancy outcomes. MATERIALS AND METHODS: In this multicenter retrospective survey study, the authors compared the pregnancy outcomes of BD patients with the healthy controls. RESULTS: A total of 298 pregnancies of 94 patients with BD and 219 pregnancies of 95 healthy controls were evaluated...
2014: Clinical and Experimental Obstetrics & Gynecology
https://www.readbyqxmd.com/read/25494126/pulmonary-embolism-and-hematologic-outcome-in-cancer-patients-initiating-chemotherapy
#18
S Keskin, T G Ler, H Kalkan, Z Keskin, K Odev
Purpose: The aim of this study was to determine the relationship between chemotherapy use and the frequency of pulmonary embolism (PE) and associated mortality, clinical, and biochemical parameters. An additional aim was to analyze computed tomography pulmonary angiography findings. Materials and Methods: The study population comprised 65 of 368 consecutive patients diagnosed with PE who underwent chemotherapy in the Medical Oncology Department. The study population had cancer of various origins, including breast, colorectal, lung, gynecological, gastric and pancreatic, lymphatic, and other sites...
July 2014: Indian Journal of Cancer
https://www.readbyqxmd.com/read/25462211/is-resveratrol-a-potential-substitute-for-leuprolide-acetate-in-experimental-endometriosis
#19
COMPARATIVE STUDY
Yesim Bayoglu Tekin, Suleyman Guven, Aynur Kirbas, Yıldıray Kalkan, Levent Tumkaya, Emine Seda Guvendag Guven
OBJECTIVE: Resveratrol, a phytoalexin polyphenol, has anti-angiogenic, antioxidant, anti-inflammatory properties. We aimed to compare the anti-inflammatory and anti-angiogenic effects of resveratrol and leuprolide acetate (LA) in an experimental endometriosis model. STUDY DESIGN: A prospective experimental study was conducted in a University Surgical Research Center. Thirty-three non-pregnant female Sprague-Dawley rats, in which experimental model of endometriosis were surgically induced were randomly divided into four groups...
January 2015: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/25451950/molecular-and-clinical-delineation-of-12-patients-with-glycogen-storage-disease-type-iii-in-western-turkey
#20
Minoru Okubo, Sema Kalkan Ucar, Teodor Podskarbi, Toshio Murase, Yoon S Shin, Mahmut Coker
BACKGROUND: Glycogen storage disease type III (GSD III; MIM #232400) is an autosomal recessive inherited disorder characterized by fasting hypoglycemia, growth retardation, hepatomegaly, progressive myopathy, and cardiomyopathy. GSD III is caused by deficiency in the glycogen debranching enzyme (gene symbol: AGL). Molecular analyses of AGL have indicated heterogeneity depending on ethnic groups. In Turkey we reported 13 different AGL mutations from GSD III patients in the Eastern region; however, the full spectrum of AGL mutations in Turkish population remains unclear...
January 15, 2015: Clinica Chimica Acta; International Journal of Clinical Chemistry
keyword
keyword
66931
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"