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Herpes zoster vaccination elderly

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https://www.readbyqxmd.com/read/27925856/clinical-and-economic-impact-of-herpes-zoster-vaccination-in-elderly-in-italy
#1
Sara Boccalini, Cristiano Alicino, Domenico Martinelli, Angela Bechini, Emilia Tiscione, Barbara Pellizzari, Rosa Prato, Giancarlo Icardi, Stefania Iannazzo, Paolo Bonanni
Herpes zoster (HZ) is a very relevant pathology among elderly people (≥ 60 years of age), with a considerable disease burden and loss of quality of life. In the last years a new vaccine against HZ became available in Italy. Therefore, the Italian decision makers are now confronted with the decision whether that vaccination should be implemented. Pharmaco-economic analyses represent useful tools to value the feasibility of new immunization programs and their sustainability. To this aim, an ad hoc population model was developed in order to value the clinical and economic impact of HZ vaccination program for the elderly in Italy...
December 7, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27765026/increasing-incidence-associated-with-herpes-zoster-infection-in-british-columbia-canada
#2
Fawziah Marra, Mei Chong, Mehdi Najafzadeh
BACKGROUND: Recent studies have shown an increasing incidence of herpes zoster (HZ) infection, which may be related to the introduction of varicella vaccination programs in children. We examined the epidemiology and treatment costs of HZ and post-herpetic neuralgia (PHN) over time in British Columbia, Canada. METHODS: The cohort consisted of all cases with HZ infection from January 1, 1997 and December 31, 2012. Incident zoster was defined as a case (ICD-9 053 or ICD-10 B02) without a previous episode of HZ or PHN in the previous 12 months...
October 20, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27624398/cost-effectiveness-analysis-of-herpes-zoster-vaccination-in-italian-elderly-persons
#3
Silvia Coretti, Paola Codella, Federica Romano, Matteo Ruggeri, Americo Cicchetti
OBJECTIVES: Herpes zoster (HZ) is characterized by a painful skin rash. Its main complication is postherpetic neuralgia (PHN), pain persisting or occurring after the rash onset. HZ treatment aims to reduce acute pain, impede the onset complications, and disease progression. The aim of this study was to assess the cost-effectiveness of HZ vaccination compared with no vaccination strategy, within the Italian context. METHODS: The natural history of HZ and PHN was mapped through a Markov model with lifetime horizon...
January 2016: International Journal of Technology Assessment in Health Care
https://www.readbyqxmd.com/read/27484158/cost-effectiveness-of-a-herpes-zoster-vaccination-program-among-the-french-elderly-people
#4
Emmanuel Belchior, Daniel Lévy-Bruhl, Yann Le Strat, Magid Herida
A vaccine against herpes zoster (HZ) and its complications has already proven safe and effective against infection and pain and against the related deterioration of quality of life in the elderly. In order to inform the vaccination decision-making process regarding inclusion of this vaccine in the French immunization schedule, we assessed the cost-effectiveness of several vaccination scenarios, compared to no vaccination. We chose to use a previously published Markov model. Starting vaccination in elderly individuals aged 65, 70 and 75 y old appears more cost-effective than vaccination for those aged 60 y old, with a cost-effectiveness ratio between 30,000 and 35,000 euros per quality-adjusted-life year (QALY) gained for the first 3 age groups versus 54,500 €; for the latter group...
September 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27279025/adult-vaccination-against-tetanus-and-diphtheria-the-european-perspective
#5
Birgit Weinberger
Besides immunizations against influenza, Streptococcus pneumoniae and herpes zoster, which are recommended specifically for the elderly regular booster vaccinations against tetanus, diphtheria and in some cases pertussis and polio are recommended in many European countries for adults including the elderly. Vaccination recommendations for adults differ greatly between individual countries and coverage data is scarce. Tetanus-specific antibody concentrations are generally higher than diphtheria-specific antibodies, and a substantial proportion of adults, and particularly of the elderly do not have protective antibody concentrations against diphtheria...
June 9, 2016: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/27262452/real-world-effectiveness-and-safety-of-a-live-attenuated-herpes-zoster-vaccine-a-comprehensive-review
#6
REVIEW
Filippo Ansaldi, Cecilia Trucchi, Cristiano Alicino, Chiara Paganino, Andrea Orsi, Giancarlo Icardi
UNLABELLED: Herpes zoster (HZ) is a common, painful and debilitating disease caused by the reactivation of latent varicella-zoster virus in ganglia. This clinical event occurs more frequently in the elderly and those who are immunocompromised. The most common complication of HZ is post-herpetic neuralgia (PHN) which is responsible for the highest HZ-related burden of illness and is challenging to treat. Due to the important clinical and economic impact of HZ and PHN, and the suboptimal treatments that are currently available, HZ vaccination is an important approach to reduce the burden of illness...
July 2016: Advances in Therapy
https://www.readbyqxmd.com/read/27224081/herpes-zoster-ophthalmicus-and-varicella-zoster-virus-vasculopathy
#7
Francisco Bandeira, Marina Roizenblatt, Guido Carlos Levi, Denise de Freitas, Rubens Belfort
Herpes zoster (HZ) corresponds to the reactivation of varicella zoster virus (VZV). Among adults, the ophthalmic division of the trigeminal nerve is one of the most common sites of involvement. Vasculopathy caused by HZ is associated with significant morbidity and mortality, affecting structures such as the brain, which can lead to stroke. In this review, we analyzed the epidemiological and clinical aspects of the vascular involvement of VZV, focusing on the peculiarities of its association with ocular HZ. A review of the available literature indicated that ocular involvement of HZ was a risk factor for vasculopathy after adjusting for age, sex, body mass index, smoking, indicators of metabolic syndrome, and vascular and heart diseases...
April 2016: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/27164323/herpes-zoster-and-the-search-for-an-effective-vaccine
#8
N Arnold, I Messaoudi
Primary infection with varicella zoster virus (VZV), an exclusively human neurotrophic alphaherpsesvirus, results in varicella, known more commonly as chickenpox. Like other alphaherpesviruses, VZV establishes latency in the sensory ganglia and can reactivate to cause herpes zoster (also known as shingles), a painful and debilitating disease, especially in elderly and immunocompromised individuals. The overall incidence of herpes zoster in Europe and the United States is three per 1000 people, but increases sharply after 60 years of age to 10 per 1000 people...
May 10, 2016: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/26969400/varicella-zoster-virus-related-deaths-and-hospitalizations-before-the-introduction-of-universal-vaccination-with-the-tetraviral-vaccine
#9
Alessandra de Martino Mota, Filipe Anibal Carvalho-Costa
OBJECTIVE: To characterize varicella zoster virus-related deaths and hospitalizations in Brazil before universal vaccination with the tetravalent (measles, mumps, rubella, and varicella) vaccine, attempting to collect baseline data on varicella morbidity and mortality in order to evaluate the impact of the varicella vaccination program. METHODS: Varicella-associated mortality data were evaluated between 1996 and 2011 and varicella zoster virus-associated hospitalizations between 1998 and 2013...
July 2016: Jornal de Pediatria
https://www.readbyqxmd.com/read/26967927/-zoster-and-postherpetic-neuralgia-vaccine-prevention-is-available
#10
Joël Belmin, Witold Jarzebowski, Carmelo Lafuente-Lafuente
Herpes zoster (HZ) infection is a common condition in the elderly. Immunosuppression involving cellular immunity favors its occurrence. The pain is the most frequent complications of HZ. It occurs in about 30% of people aged over 70 years. The virological diagnosis of typical HZ is not useful, and the diagnosis is mainly based on clinical data. Skin care is essential to limit cutaneous damage. Antiviral drugs will reduce the risk of post-herpetic neuralgia, if they are early prescribed within 72 hours after the rash onset...
September 2015: Gériatrie et Psychologie Neuropsychiatrie du Vieillissement
https://www.readbyqxmd.com/read/26835890/current-and-future-effects-of-varicella-and-herpes-zoster-vaccination-in-germany-insights-from-a-mathematical-model-in-a-country-with-universal-varicella-vaccination
#11
Johannes Horn, André Karch, Oliver Damm, Mirjam E Kretzschmar, Anette Siedler, Bernhard Ultsch, Felix Weidemann, Ole Wichmann, Hartmut Hengel, Wolfgang Greiner, Rafael T Mikolajczyk
Varicella zoster virus (VZV) is primarily known for causing varicella in childhood, but can reactivate again as herpes zoster (HZ) after a period of latency, mainly in persons older than 50 years. Universal varicella vaccination was introduced in Germany in 2004, while HZ vaccination has not been recommended yet. We aimed to quantify the potential long-term effects of universal childhood varicella vaccination and HZ vaccination of the elderly on varicella and HZ incidence in Germany over a time horizon of 100 years, using a transmission model calibrated to pre-vaccination data and validated against early post-vaccination data...
July 2, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/26605507/efficacy-and-safety-of-live-varicella-zoster-vaccine-in-diabetes-a-randomized-double-blind-placebo-controlled-trial
#12
A Hata, F Inoue, Y Hamamoto, M Yamasaki, J Fujikawa, H Kawahara, Y Kawasaki, S Honjo, H Koshiyama, E Moriishi, Y Mori, T Ohkubo
AIMS: To elucidate varicella zoster virus (VZV)-specific cell-mediated immunity and humoral immunogenicity against live attenuated Oka varicella zoster vaccine concurrently vaccinated with 23-valent pneumococcal polysaccharide vaccine (PPSV23) in elderly people with diabetes mellitus. METHODS: This double-blind randomized controlled single-centre study of 60-70-year-old people with diabetes compared immunity and safety profiles 3 months after one dose of varicella zoster vaccine or placebo...
August 2016: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/26512167/awareness-knowledge-and-vaccine-acceptability-of-herpes-zoster-in-korea-a-multicenter-survey-of-607-patients
#13
Nam Kyung Roh, Young Min Park, Hoon Kang, Gwang Seong Choi, Beom Joon Kim, Yang Won Lee, Bark Lynn Lew, Woo Young Sim
BACKGROUND: Herpes zoster (HZ) infection can significantly impair the quality of life of the affected individuals, and its treatment imposes a considerable cost burden on the health-care system and on society at large. However, there is little information on the perception of this disease and the acceptability of vaccines in Korea. OBJECTIVE: The aim of this study is to determine the awareness of HZ and its vaccine, and to identify factors associated with the acceptability of the HZ vaccine among outpatients of dermatology clinics...
October 2015: Annals of Dermatology
https://www.readbyqxmd.com/read/26510703/attitudes-of-dutch-general-practitioners-towards-vaccinating-the-elderly-less-is-more
#14
Renske Eilers, Paul F M Krabbe, Hester E de Melker
BACKGROUND: In many European countries, vaccinations are offered to the elderly. Expanding the programme to include routine vaccination against pneumococcal disease, herpes zoster, and pertussis, for example, could reduce disease burden amongst the growing population of persons aged 50 years and older. Since most countries involve general practitioners (GPs) in the programmes, the potential success of such new vaccinations depends on the attitude of GPs towards these vaccinations. This qualitative study explores Dutch GPs' attitudes regarding vaccination in general, and their attitudes regarding the incorporation of additional vaccines in the current Dutch influenza vaccination programme...
2015: BMC Family Practice
https://www.readbyqxmd.com/read/26452397/cellular-and-humoral-responses-to-a-second-dose-of-herpes-zoster-vaccine-administered-10-years-after-the-first-dose-among-older-adults
#15
Myron J Levin, Kenneth E Schmader, Lei Pang, Angela Williams-Diaz, Gary Zerbe, Jennifer Canniff, Michael J Johnson, Yupanqui Caldas, Alice Cho, Nancy Lang, Shu-Chih Su, Janie Parrino, Zoran Popmihajlov, Adriana Weinberg
BACKGROUND: Herpes zoster vaccine (ZV) was administered as a second dose to 200 participants ≥ 70 years old who had received a dose of ZV ≥ 10 years previously (NCT01245751). METHODS: Varicella zoster virus (VZV) antibody titers (measured by a VZV glycoprotein-based enzyme-linked immunosorbent assay [gpELISA]) and levels of interferon γ (IFN-γ) and interleukin 2 (IL-2; markers of VZV-specific cell-mediated immunity [CMI], measured by means of ELISPOT analysis) in individuals aged ≥ 70 years who received a booster dose of ZV were compared to responses of 100 participants aged 50-59 years, 100 aged 60-69 years, and 200 aged ≥ 70 years who received their first dose of ZV...
January 1, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/26151783/severe-autoimmune-adverse-events-post-herpes-zoster-vaccine-a-case-control-study-of-adverse-events-in-a-national-database
#16
Yi Chun Lai, Yik Weng Yew
Zoster vaccine is recommended to reduce the incidence of herpes zoster and its complication of postherpetic neuralgia in older adults. However, there have been reports of autoimmune side effects post vaccination. We therefore aim to investigate the possible relationship of severe autoimmune adverse events (arthritis, vasculitis, systemic lupus erythematosus, thrombocytopenia, alopecia, Guillain-Barre syndrome, optic neuritis and multiple sclerosis) post zoster vaccination with a matched case-control study of reported events in the Vaccine Adverse Event Reporting System (VAERS)...
July 2015: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/26041469/systematic-review-of-models-assessing-the-economic-value-of-routine-varicella-and-herpes-zoster-vaccination-in-high-income-countries
#17
REVIEW
Oliver Damm, Bernhard Ultsch, Johannes Horn, Rafael T Mikolajczyk, Wolfgang Greiner, Ole Wichmann
BACKGROUND: A systematic review was conducted to assess the cost-effectiveness of routine varicella and herpes zoster (HZ) vaccination in high-income countries estimated by modelling studies. METHODS: A PubMed search was performed to identify relevant studies published before October 2013. Studies were included in the review if they (i) evaluated the cost-effectiveness of routine childhood or adolescent varicella vaccination and/or HZ vaccination targeting the elderly, and if they (ii) reported results for high-income countries...
2015: BMC Public Health
https://www.readbyqxmd.com/read/26032932/estimated-human-and-economic-burden-of-four-major-adult-vaccine-preventable-diseases-in-the-united-states-2013
#18
John M McLaughlin, Justin J McGinnis, Litjen Tan, Annette Mercatante, Joseph Fortuna
Low uptake of routinely recommended adult immunizations is a public health concern. Using data from the peer-reviewed literature, government disease-surveillance programs, and the US Census, we developed a customizable model to estimate human and economic burden caused by four major adult vaccine-preventable diseases (VPD) in 2013 in the United States, and for each US state individually. To estimate the number of cases for each adult VPD for a given population, we multiplied age-specific incidence rates obtained from the literature by age-specific 2013 Census population data...
August 2015: Journal of Primary Prevention
https://www.readbyqxmd.com/read/25928713/increasing-trends-of-herpes-zoster-in-australia
#19
Raina MacIntyre, Alicia Stein, Christopher Harrison, Helena Britt, Abela Mahimbo, Anthony Cunningham
BACKGROUND: Increasing trends in incidence of herpes zoster (HZ) have been reported in Australia and internationally. This may reflect the impact of childhood VZV vaccination programs introduced universally in Australia in late 2005. The objective of this study was to evaluate changes in incidence of HZ and PHN in Australia over time, and associated healthcare resource utilisation. METHODS: Australian data on general practice (GP) encounters for HZ, specific antiviral prescribing data from the pharmaceutical benefits scheme, emergency department presentations from the states of NSW and Victoria and national hospitalisation data for HZ were analysed for time trends using regression models...
2015: PloS One
https://www.readbyqxmd.com/read/25483534/the-burden-of-disease-of-herpes-zoster-in-tuscany
#20
Miriam Levi, Irene Bellini, Leonardo Capecchi, Luca Pieri, Angela Bechini, Sara Boccalini, Silvia Callaioli, Roberto Gasparini, Donatella Panatto, Emilia Tiscione, Paolo Bonanni
Herpes zoster (HZ) is a disease caused by the reactivation of the latent α-herpes virus varicella zoster virus (VZV), for which, in Italy, a specific surveillance system does not exist, but around 200 000 cases are estimated each year. In older patients, who are at increased risk of developing HZ, symptoms are more severe and the chances to develop postherpetic neuralgia (PHN), the most severe complication, are substantially higher. A vaccine against HZ with demonstrated efficacy and an acceptable safety profile is now available and is recommended in Europe for adults >50 years...
2015: Human Vaccines & Immunotherapeutics
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