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https://www.readbyqxmd.com/read/28090595/a-case-of-coats-disease-and-concurrent-anisometropic-amblyopia
#1
Nathan G Lambert, Robert O Hoffman, M Elizabeth Hartnett
PURPOSE: The aim of this report was to demonstrate a case of Coats disease in a patient with concurrent anisometropic amblyopia. OBSERVATIONS: A 10-year-old boy was diagnosed with Coats disease during routine ophthalmic examination. Visual acuity was 20/20 OD and 20/50 OS with cycloplegic refraction of +1.25 (OD) and +3.25 (OS). Examination under anesthesia showed macular exudates in the left eye that encroached near the fovea superotemporally. Despite the poor visual acuity and macular exudates, the foveal architecture of both eyes appeared normal on spectral domain optical coherence tomography...
December 2016: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/28088662/metabolic-profiles-of-exudates-from-chronic-leg-ulcerations
#2
Adam Junka, Wojciech Wojtowicz, Adam Ząbek, Grzegorz Krasowski, Danuta Smutnicka, Barbara Bakalorz, Agnieszka Boruta, Mariusz Dziadas, Piotr Młynarz, Parish Paymon Sedghizadeh, Marzenna Bartoszewicz
Chronic leg ulceration is a disease usually associated with other comorbidities, and significantly reduces patient quality of life. Infected leg ulcers can lead to limb-threatening sequelae or mortality. Leg ulcerations are colonized by a number of microbes that are able to cause life-threating infections in susceptible patients. Wound exudate is a body fluid that collects metabolites from patient eukaryotic cells and from prokaryotic bacterial communities inhabiting the wound. This study aimed at identification of metabolites in exudates collected from chronic leg ulcers, and correlation of this metabolome with patient comorbidities and microbiological status of the wound...
January 10, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28087073/abnormal-mortality-of-octopus-after-a-storm-water-event-accumulated-lead-and-lead-isotopes-as-fingerprints
#3
J Raimundo, F Ruano, J Pereira, M Mil-Homens, P Brito, C Vale, M Caetano
Octopus vulgaris is a sedentary organism that inhabits coastal waters being exposed to anthropogenic compounds. Lead concentration in coastal environments reflects many processes and activities namely weathering, industrial and domestic discharges, and atmospheric deposition. Since lead isotopic composition is little affected by kinetic processes occurring between source and sink, its signature has been used to identify different Pb sources. After a short-term heavy rainfall, hundreds of octopus appeared dead in two Portuguese coastal areas...
January 10, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28081323/acute-exudative-tonsillitis-in-adults-the-use-of-the-centor-scoreand-some-laboratory-tests
#4
Yavuz Furuncuoğlu, Filiz Sağlam, Ahmet Kutluhan
BACKGROUND/AIM: The aim of our study was to determine the usefulness of the Centor score and some basic laboratory tests (complete blood count and C-reactive protein) for the differential diagnosis of exudative tonsillitis due to Group A β-hemolytic streptococcus (GABHS) or due to non-GABHS agents. MATERIALS AND METHODS: The data of clinical and laboratory characteristics of the patients diagnosed with exudative tonsillitis were collected and statistically compared between those having positive GABHS throat culture result and those who were negative for any bacterial agent...
December 20, 2016: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28080896/traumatic-foreign-body-pericarditis-in-a-toco-toucan-ramphastos-toco
#5
Mireia Máinez, Jorge Rosell, Roger Such, Teresa Cardona, Carles Juan-Sallés
An approximately 10-yr-old, captive-born female toco toucan ( Ramphastos toco ) was presented due to an acute onset of depression and apathy. On visual and physical examination, it showed an abnormal posture and dehydration, respectively. Serum biochemistry revealed hyperuricemia (39.4 mg/dl) and elevated glutamic oxaloacetic transaminase (GOT; 1,050 U/L). Radiographs demonstrated an enlargement of the cardiac silhouette. The bird died 7 days after presentation, despite treatment with enrofloxacin, allopurinol, a preparation of hepatorenal protectors, and complex B vitamins with dextrose...
December 2016: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28079756/optical-coherence-tomography-angiography-changes-in-early-type-3-neovascularization-after-anti-vascular-endothelial-growth-factor-treatment
#6
Alexandra Miere, Giuseppe Querques, Oudy Semoun, Francesca Amoroso, Olivia Zambrowski, Thibaut Chapron, Vittorio Capuano, Eric H Souied
PURPOSE: To investigate the morphologic changes on optical coherence tomography angiography (OCTA) of treatment-naive Type 3 neovascularization secondary to exudative age-related macular degeneration after 1 year of anti-vascular endothelial growth factor therapy. METHODS: Consecutive patients diagnosed with treatment-naive early-stage Type 3 neovascularization were enrolled in this retrospective study. All patients underwent color fundus photographs/MultiColor (Heidelberg Engineering) imaging, fluorescein angiography, indocyanine green angiography, structural spectral domain OCT, and OCTA Optovue RTVue XR Avanti (Optovue) at baseline, and repeated OCTA and structural spectral domain OCT at Month 12...
January 10, 2017: Retina
https://www.readbyqxmd.com/read/28079399/safety-and-efficacy-of-tissue-plasminogen-activator-tpa-and-deoxyribonuclease-dnase-for-complicated-pleural-effusions-secondary-to-abdominal-pathology
#7
Adnan Majid, Sebastian Ochoa, Sumit Chatterji, Sebastian Fernandez-Bussy, Fayez Kheir, Estefania Rivera, George Cheng, Erik Folch
RATIONALE: Exudative pleural effusions may arise secondary to inflammation of intra-abdominal structures. Pleural space loculations can complicate these effusions, preventing adequate chest tube drainage and leading to consideration of surgical intervention. Previous studies have demonstrated that intrapleural administration of tissue plasminogen activator (tPA) combined with human recombinant deoxyribonuclease (DNase) can improve fluid drainage and reduce surgery for patients with loculated parapneumonic effusions; however, the efficacy of this treatment has not been evaluated for complicated pleural effusions attributed to intraabdominal inflammation...
January 12, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28077200/expression-of-heat-shock-protein-70-in-transport-stressed-broiler-pectoralis-major-muscle-and-its-relationship-with-meat-quality
#8
T Xing, M F Wang, M Y Han, X S Zhu, X L Xu, G H Zhou
Omics research has indicated that heat shock protein 70 (HSP70) is a potential biomarker of meat quality. However, the specific changes and the potential role of HSP70 in postmortem meat quality development need to be further defined. In this study, Arbor Acres broiler chickens (n=126) were randomly categorized into three treatment groups of unstressed control (C), 0.5-h transport (T) and subsequent water shower spray following transport (T/W). Each treatment consisted of six replicates with seven birds each...
January 12, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28076566/efficacy-of-aflibercept-on-exudative-age-related-macular-degeneration-in-patients-exhibiting-complete-ranibizumab-resistance-and-tachyphylaxis
#9
Gokcen Gokce, Ali Hakan Durukan, Mehmet Talay Koylu, Murat Kucukevcilioglu
Purpose: The present study compared the efficacy of aflibercept for neovascular age-related macular degeneration (NV-AMD) in patients with complete ranibizumab resistance and tachyphylaxis. Methods: Forty-four eyes of 38 neovascular age-related macular degeneration patients were evaluated. Eyes were divided into a complete resistance group (n=23 eyes) and tachyphylaxis group (n=21 eyes). Results: After three injections, eight (38.1%) patients in the tachyphylaxis group and nine (39...
November 2016: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/28073916/ceramide-cd300f-binding-inhibits-lipopolysaccharide-induced-skin-inflammation
#10
Emiko Shiba, Kumi Izawa, Ayako Kaitani, Masamichi Isobe, Akie Maehara, Koichiro Uchida, Keiko Maeda, Nobuhiro Nakano, Hideoki Ogawa, Ko Okumura, Toshio Kitamura, Toshiaki Shimizu, Jiro Kitaura
Lipopolysaccharide (LPS) triggers inflammatory responses; however, the negative regulation of LPS responses in vivo remains poorly understood. CD300f is an inhibitory receptor among the CD300 family of paired activating and inhibitory receptors. We have previously identified ceramide as a ligand for CD300f and shown that the binding of ceramide to CD300f inhibits IgE-mediated mast cell activation and allergic responses in mouse models. Here we identify the critical role of CD300f in inhibiting LPS-induced skin inflammation...
January 10, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28073559/characterization-of-total-retinoid-like-activity-of-compounds-produced-by-three-common-phytoplankton-species
#11
Eliška Sychrová, Jana Priebojová, Marie Smutná, Kateřina Nováková, Jiří Kohoutek, Klára Hilscherová
Phytoplankton can produce various bioactive metabolites, which may affect other organisms in the aquatic environment. This study provides the first information on the total retinoid-like activity associated with both intracellular and extracellular metabolites produced by selected phytoplankton species that could play a role in teratogenic effects and developmental disruption in exposed organisms. The studied species included a coccoid cyanobacteria (Microcystis aeruginosa), a filamentous cyanobacteria (Aphanizomenon gracile) and a green alga (Desmodesmus quadricauda), all of which commonly occur in freshwater bodies in Europe...
December 2016: Harmful Algae
https://www.readbyqxmd.com/read/28073080/impact-of-environmental-factors-on-the-culturability-and-viability-of-listeria-monocytogenes-under-conditions-encountered-in-food-processing-plants
#12
Anaïs Overney, Joséphine Jacques-André-Coquin, Patricia Ng, Brigitte Carpentier, Laurent Guillier, Olivier Firmesse
The ability of Listeria monocytogenes to adhere to and persist on surfaces for months or even years may be responsible for its transmission from contaminated surfaces to food products. Hence the necessity to find effective means to prevent the establishment of L. monocytogenes in food processing environments. The aim of this study was to assess, through a fractional experimental design, the environmental factors that could affect the survival of L. monocytogenes cells on surfaces to thereby prevent the persistence of this pathogen in conditions mimicking those encountered in food processing plants: culture with smoked salmon juice or meat exudate, use of two materials with different hygiene status, biofilm of L...
December 21, 2016: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/28072560/a-prostacyclin-analog-cicaprost-exhibits-potent-anti-inflammatory-activity-in-human-primary-immune-cells-and-a-uveitis-model
#13
Jenny W Wang, Chau Vu, Neil J Poloso
PURPOSE: To investigate the therapeutic potential of a prostacyclin (IP) receptor agonist for ocular inflammation and the effect on immune cells. METHODS: The anti-inflammatory activities of cicaprost were determined in primary human monocyte-derived macrophages and human monocyte-derived dendritic cells (MoDC), as well as a lipopolysaccharides (LPS)-induced rat uveitis model. Multiple cytokine release was measured by utilizing Luminex Technology. Prostacyclin (IP) Receptor expression was detected by reverse transcription-polymerase chain receptor...
January 10, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28070472/utilizing-the-veraflo%C3%A2-instillation-negative-pressure-wound-therapy-system-with-advanced-care-for-a-case-study
#14
Rita K Driver
BACKGROUND:  Mankind has always suffered wounds throughout time due to trauma, disease, and lifestyles. Many wounds are non-healing and have continued to be challenging. However, utilizing advanced wound care treatments, such as negative pressure wound treatment with instillation and dwell time (NPWTi-d), has proven beneficial. NPWTi-d is indicated in a variety of wounds, such as trauma, surgical, acute, pressure injuries, diabetic foot ulcers, and venous leg ulcers. Bacteria and bioburden interrupts wound healing by increasing the metabolic needs, ingesting, and robbing the necessary nutrients and oxygen...
November 30, 2016: Curēus
https://www.readbyqxmd.com/read/28069646/snapshot-profiling-of-anti-leishmanial-potency-of-lead-compounds-and-drug-candidates-against-intracellular-l-donovani-amastigotes-with-focus-on-human-derived-host-cells
#15
Markella Koniordou, Stephen Patterson, Susan Wyllie, Karin Seifert
This study characterised in vitro potencies of anti-leishmanial agents against intracellular Leishmania donovani amastigotes in primary human macrophages, obtained with or without CD14-positive monocyte enrichment, phorbol 12-myristate 13-acetate (PMA) differentiated THP-1 cells and mouse peritoneal exudate macrophages (PEMs). Host cell dependent potency was confirmed for pentavalent and trivalent antimony. Fexinidazole was inactive against intracellular amastigotes across the host cell panel. Fexinidazole sulfone, (R)-PA-824, (S)-PA-824 and VL-2098 displayed similar potency in all host cells tested...
January 9, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28067720/swept-source-optical-coherence-tomography-evaluation-of-chorioretinal-changes-in-hypertensive-choroidopathy-related-to-hellp-syndrome
#16
Daniel Velazquez-Villoria, Pablo Marti Rodrigo, Maria L DeNicola, Miguel A Zapata Vitori, Antonio Segura García, Jose García-Arumí
PURPOSE: To report a case of hypertensive choroidopathy with detailed chorioretinal images obtained using swept source optical coherence tomography. METHODS: We report the case of a 36-year-old pregnant woman who presented with extensive bilateral exudative retinal detachments (visual acuity of hands movement bilaterally), high blood pressure, and severe alteration of the laboratory test results resulting in the diagnosis of HELLP syndrome. The baby was delivered by emergency cesarean section and the patient was hospitalized in the intensive care unit...
January 6, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28064133/microalgae-cultivation-in-urban-wastewater-coelastrum-cf-pseudomicroporum-as-a-novel-carotenoid-source-and-a-potential-microalgae-harvesting-tool
#17
Bárbara Úbeda, José Ángel Gálvez, Mónica Michel, Ana Bartual
The aim of this work was to study the optimal growth and high value-added production of the microalgae Coelastrum cf. pseudomicroporum Korshikov cultivated in urban wastewater. It was observed that C. cf. pseudomicroporum grew ideally in this medium, acting as an efficient nutrient starver. Additionally, the obtained biomass increased carotenoid cell content after saltwater stress. The effects of light intensity and salt stress on its growth rate were analysed. The results showed that this alga can grow very fast using wastewater as culture medium, reaching maximum growth rates of 1...
December 30, 2016: Bioresource Technology
https://www.readbyqxmd.com/read/28063713/phytoavailability-and-mechanism-of-bound-pah-residues-in-filed-contaminated-soils
#18
Yanzheng Gao, Xiaojie Hu, Ziyuan Zhou, Wei Zhang, Yize Wang, Bingqing Sun
Understanding the phytoavailability of bound residues of polycyclic aromatic hydrocarbons (PAHs) in soils is essential to assessing their environmental fate and risks. This study investigated the release and plant uptake of bound PAH residues (reference to parent compounds) in field contaminated soils after the removal of extractable PAH fractions. Plant pot experiments were performed in a greenhouse using ryegrass (Lolium multiflorum Lam.) to examine the phytoavailablility of bound PAH residues, and microcosm incubation experiments with and without the addition of artificial root exudates (AREs) or oxalic acid were conducted to examine the effect of root exudates on the release of bound PAH residues...
January 4, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28062974/heterologous-synthesis-of-geranyllinalool-a-diterpenol-plant-product-in-the-cyanobacterium-synechocystis
#19
Cinzia Formighieri, Anastasios Melis
Cyanobacteria are industrially robust photosynthetic microorganisms that can be genetically programmed to synthesize commodity products for domestic and industrial consumption. In the present work, Synechocystis was endowed with the synthesis of the plant secondary metabolite geranyllinalool, a diterpene alcohol of commercial interest. Total average yields of 360 μg of geranyllinalool per gram of dry cell weight were obtained in the course of a 48-h cultivation period. Geranyllinalool was primarily sequestered inside the transformant cells, corresponding to 60-70% of the total heterologous product, instead of being entirely exuded, as the case is with shorter heterologous terpene hydrocarbons...
January 6, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28060399/are-multiple-retinal-arterial-macroaneurysms-considered-a-sign-of-cerebral-aneurysms
#20
Serhad Nalcaci, Zafer Oztas, Cenk Eraslan, Cezmi Akkin
The aim of this study is to report the coexistence of retinal arterial macroaneurysms (RAMs) and cerebral aneurysms (CAs) in a 58-year-old woman with hypertension. She was noted as having a 1-week history of vision loss in her left eye, along with a 2-month history of a nonspecific headache. Visual acuity was 20/32 in her left eye and 20/20 in her right eye. A fundus examination revealed multiple areas of retinal hemorrhages that were surrounded by circinate exudation in her left eye, as well as the generalized attenuation of the retinal arteries in both of her eyes...
January 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
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