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Bile tract cancer

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https://www.readbyqxmd.com/read/29662598/-clinical-epidemiological-and-therapeutic-features-of-biliary-tract-cancers-about-20-cases
#1
Ibrahima Ka, Magatte Faye, Papa Saloum Diop, Amadou Bocar Niang Aliou Coly Faye, Jean Marc Ndoye, Babacar Fall
Biliary tract cancers mainly occur in two sites: gallbladder cancer which are adenocarcinomas and intra- and extrahepatic cholangiocarcinomas. We conducted a retrospective study of 20 cases with biliary tract cancer in the Department of Surgery at the General Hospital in Grand-Yoff between January 2006 and October 2014. 40% of patients had gallbladder cancer, 60% of patients had common bile duct cancer. Sex ratio was 1. The average age of patients was 58.1 years. The average time to diagnosis was 3.77 months...
2018: Pan African Medical Journal
https://www.readbyqxmd.com/read/29622390/-therapeutic-advances-in-the-management-of-biliary-tract-carcinoma
#2
Sophie-Clémentine Ribiere, Chloé Léandri, Marie-Anne Guillaumot, Catherine Brezault, Romain Coriat
Cancers of the bile ducts or cholangiocarcinomas are a rare entity whose incidence is increasing in France. Surgical resection of cholangiocarcinoma remains the only curative therapy. Adjuvant therapy with capecitabine at a fixed dose of 1250mg/m2 twice daily from day 1 to day 14 (21-day cycle) for a 6 months period is now the standard of care after curative surgery. At a metastatic stage, the reference treatment consists of the combination of a platinum salt in addition to gemcitabine. No biomarker has been identified to predict the response to chemotherapy...
April 2, 2018: La Presse Médicale
https://www.readbyqxmd.com/read/29605722/efficacy-of-eus-and-ercp-guided-biliary-drainage-for-malignant-biliary-obstruction-prospective-randomized-controlled-study
#3
Joo Kyung Park, Young Sik Woo, Donghyo Noh, Ju-Il Yang, So Young Bae, Hwan Sic Yun, Jong Kyun Lee, Kyu Taek Lee, Kwang Hyuck Lee
BACKGROUND AND AIMS: ERCP-guided biliary drainage (ERCP-BD is a criterion standard treatment for malignant biliary obstruction when curative surgery is not an option. Alternative methods such as PTBD would significantly lower the quality of life. EUS-guided biliary drainage (EUS-BD) has been developed and performed by experienced endoscopists. Therefore, the aims of this study were to evaluate the efficacy and safety of EUS-BD compared with ERCP in malignant biliary obstruction. METHODS: The prospective randomized controlled study was conducted and 30 patients were enrolled; 15 for each EUS-BD and ERCP-BD arm...
March 29, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29588511/structure-and-distribution-of-an-unrecognized-interstitium-in-human-tissues
#4
Petros C Benias, Rebecca G Wells, Bridget Sackey-Aboagye, Heather Klavan, Jason Reidy, Darren Buonocore, Markus Miranda, Susan Kornacki, Michael Wayne, David L Carr-Locke, Neil D Theise
Confocal laser endomicroscopy (pCLE) provides real-time histologic imaging of human tissues at a depth of 60-70 μm during endoscopy. pCLE of the extrahepatic bile duct after fluorescein injection demonstrated a reticular pattern within fluorescein-filled sinuses that had no known anatomical correlate. Freezing biopsy tissue before fixation preserved the anatomy of this structure, demonstrating that it is part of the submucosa and a previously unappreciated fluid-filled interstitial space, draining to lymph nodes and supported by a complex network of thick collagen bundles...
March 27, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29584696/%C3%AE-4-and-%C3%AE-6-integrin-expression-is-associated-with-the-subclassification-and-clinicopathological-features-of-intrahepatic-cholangiocarcinoma
#5
Yurie Soejima, Miho Takeuchi, Takumi Akashi, Motoji Sawabe, Toshio Fukusato
Intrahepatic cholangiocarcinoma (ICC) is a heterogeneous group of cancers of the intrahepatic biliary tract. However, few studies have evaluated integrin expression according to an ICC subgroup. We immunohistochemically investigated α6β4 (β4) and αvβ6 (β6) integrin expressions in 48 ICCs, and evaluated their relationship with clinical and pathological parameters and ligand expression, as well as transforming growth factor (TGF)-β1. β4 and β6 expressions were detected in 46 (96%) and 35 (73%) ICC cases, respectively...
March 27, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29562907/tumor-infiltrating-mast-cells-predict-prognosis-and-gemcitabine-based-adjuvant-chemotherapeutic-benefit-in-biliary-tract-cancer-patients
#6
Xiaobo Bo, Jie Wang, Tao Suo, Xiaoling Ni, Han Liu, Sheng Shen, Min Li, Yueqi Wang, Houbao Liu, Jiejie Xu
BACKGROUND: Recent studies have reported TIMs play an important role in tumors progression or regression, but the effect of TIMs in biliary tract cancer remains unclear. The aim of this study is to investigate the prognostic value of tumor infiltrating mast cells (TIMs) and its influence on gemcitabine-based adjuvant chemotherapy (ACT) benefits in biliary tract cancer patients after surgery. METHODS: TIMs were evaluated by immunohistochemical staining of tryptase in 250 patients with resected gallbladder carcinoma (GBC) or extrahepatic bile duct carcinoma (EBDC) from Zhongshan Hospital...
March 21, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29549099/metabolism-of-oxo-bile-acids-and-characterization-of-recombinant-12%C3%AE-hydroxysteroid-dehydrogenases-from-bile-acid-7%C3%AE-dehydroxylating-human-gut-bacteria-clostridium-scindens-atcc-35704-clostridium-hylemonae-dsm-15053-and-clostridium-hiranonis-dsm-13275
#7
Heidi Doden, Lina A Sallam, Saravanan Devendran, Lindsey Ly, Greta Doden, Steven L Daniel, João M P Alves, Jason M Ridlon
Bile acids are important cholesterol-derived nutrient signaling hormones, synthesized in the liver, that act as detergents to solubilize dietary lipids. Bile acid 7α-dehydroxylating gut bacteria generate the toxic bile acids deoxycholic acid and lithocholic acid from host bile acids. The ability of these bacteria to remove the 7-hydroxyl group is partially dependent on 7α-hydroxysteroid dehydrogenase (HSDH) activity which reduces 7-oxo-bile acids generated by other gut bacteria. 3α-HSDH is an important enzymatic activity in the bile acid 7α-dehydroxylation pathway...
March 16, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29541466/diagnostic-usefulness-of-kl-6-concentration-of-bile-in-biliary-tract-cancer
#8
Takumi Onoyama, Kazuya Matsumoto, Hiroki Koda, Taro Yamashita, Hiroki Kurumi, Soichiro Kawata, Yohei Takeda, Kenichi Harada, Kazuo Yashima, Hajime Isomoto
The sensitivity of bile cytology for biliary tract cancer varies from 6-64%, and hence remains unsatisfactory. Sialylated carbohydrate antigen KL-6 mucin is positive in biliary tract cancer tissues and serum KL-6 levels are significantly increased in intrahepatic ductal adenocarcinoma patients compared with healthy individuals. The aim of the present study was to evaluate the usefulness of the KL-6 concentration of bile for the diagnosis of biliary tract cancer. Bile cytology and measurements of bile KL-6 concentration were conducted for 43 patients (25 biliary tract cancers and 18 benign biliary disease)...
April 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29521205/bile-acid-derivatives-from-old-molecules-to-a-new-potent-therapeutical-use-an-overview
#9
Marine Blanchet, Jean Michel Brunel
Bile acids or bile salts, belong to a large family of biological steroid derivatives found predominantly in the bile of mammals and other vertebrates. These amphipathic molecules possess numerous functions, including eliminating cholesterol from the body, driving the flow of bile to eliminate catabolites, emulsifying fat-soluble vitamins to enable their absorption, aiding in motility and in reducing the bacteria flora found in the small intestine and biliary tract. In this review, we investigate progress towards synthetic bile acid derivatives, with special emphasis on how they might be used for various biological applications and the challenges that remain in developing these compounds as potent drugs of the future especially in the field of microbiology (antimicrobial activities) and cancer (anticancer agents)...
March 8, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29503819/granulin-secreted-by-the-food-borne-liver-fluke-opisthorchis-viverrini-promotes-angiogenesis-in-human-endothelial-cells
#10
Brandon Haugen, Shannon E Karinshak, Victoria H Mann, Anastas Popratiloff, Alex Loukas, Paul J Brindley, Michael J Smout
The liver fluke Opisthorchis viverrini is a food-borne, zoonotic pathogen endemic to Thailand and adjacent countries in Southeast Asia. The adult developmental stage of the O. viverrini parasite excretes and secretes numerous proteins within the biliary tract including the gall bladder. Lesions caused by the feeding activities of the liver fluke represent wounds that undergo protracted cycles of healing and re-injury during chronic infection, which can last for decades. Components of the excretory/secretory (ES) complement released by the worms capably drive proliferation of bile duct epithelial cells and are implicated in establishing the oncogenic milieu that leads to bile duct cancer, cholangiocarcinoma...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29484561/bactibilia-in-diseases-of-the-biliary-tract-and-pancreatic-gland-in-patients-older-than-80-years-a-strobe-retrospective-cohort-study-in-a-teaching-hospital-in-italy
#11
Paola Di Carlo, Nicola Serra, Gaspare Gulotta, Anna Giammanco, Claudia Colomba, Giuseppina Melfa, Teresa Fasciana, Consolato Sergi
Bile is a lipid-rich sterile solution produced in the liver that can be infected resulting in bactibilia. A higher incidence of postoperative infectious complications has been seen in patients with bactibilia. Recently, gram-negative bacteria have been linked to a tumor-associated inflammatory status. This study is a retrospective cohort study of 39 patients, who are over 80 years of age only (53.85% males and 46.15% females), hospitalized with diseases of the biliopancreatic system in one teaching hospital in Italy from January 2011 to December 2012 with a follow-up of 5 years...
February 27, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29452147/combination-of-kras-activation-and-pten-deletion-contributes-to-murine-hepatopancreatic-ductal-malignancy
#12
Yun-Kai Lin, Zheng Fang, Tian-Yi Jiang, Zheng-Hua Wan, Yu-Fei Pan, Yun-Han Ma, Yuan-Yuan Shi, Ye-Xiong Tan, Li-Wei Dong, Yong-Jie Zhang, Hong-Yang Wang
Kras mutations are among the most common genetic abnormalities in human neoplasms, including cholangiocarcinomas, pancreatic cancer and colon cancer. PTEN has previously been associated with cholangiocarcinoma development in murine models. Here, we have established novel mouse models of neoplasms by liver-specific and biliary-pancreatic Kras activation and PTEN deletion. By liver-specific disruption of PTEN and activation of Kras in mice caused rapid development of intrahepatic biliary epithelial proliferative lesions (Intrahepatic cholangiocarcinoma, ICC), which progress through dysplasia to invasive carcinoma...
February 13, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29402439/drug-development-and-clinical-trial-design-in-pancreatico-biliary-malignancies
#13
REVIEW
Jennifer Harrington, Louise Carter, Bristi Basu, Natalie Cook
Pancreatico-biliary (P-B) tumors arise from the pancreas, bile duct, and ampulla of Vater. Despite their close anatomical location, they have different etiology and biology. However, they uniformly share a poor prognosis, with no major improvements observed in overall survival over decades, even in the face of progress in diagnostic imaging and surgical techniques, and advances in systemic and loco-regional radiation therapies. To date, cytotoxic treatment has been associated with modest benefits in the advanced disease setting, and survival for patients with stage IV disease has not exceeded a year...
January 8, 2018: Current Problems in Cancer
https://www.readbyqxmd.com/read/29394711/-a-case-report-of-long-term-survival-after-excision-for-needle-tract-implantation-of-biopsy-and-hepatectomy-for-cholangiocarcinoma-with-gall-bladder-hemorrhage
#14
Kotaro Miyazawa, Shigeru Yoshioka, Masayuki Shiobara, Kazuo Wakatsuki, Syuka Arai, Kosuke Suda, Toshiaki Aida, Tetsutaro Miyoshi, Hirofumi Saito, Kazuto Yamazaki
A 77-year-old men with abdominal pain suffered from gall bladder hemorrhage and liver abcess was admitted for intensive care of severe acute cholangitis. He had hemobilia which was treated by the endoscopic retrograde bile duct drainage. After 2 months treatment with rest for purulent myelitis, he had neoplastic change of liver abcess diagnosed as intrahepatic bile duct cancer by percutaneous core needle biopsy. He underwent surgery as central bisegmentectomy and left the hospital at home 3 months later after rehabilitation for surgical site infection...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29388136/isolation-of-extracellular-rna-from-bile
#15
Irene K Yan, Valentin X Berdah, Tushar Patel
The study of extracellular RNA has been recently reported as a tool for biomarker discovery. Extracellular vesicles can be isolated from different types of body fluids which contain protein, mRNA, and noncoding RNA. Extracellular RNA isolated from bile could be a useful tool for analyzing biliary tract diseases or cancer. Herein, we describe protocols based on modifications of commercially available kits for the collection, processing, and isolation of extracellular RNA from bile.
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29339651/albumin-indocyanine-green-evaluation-grading-system-predicts-post-hepatectomy-liver-failure-for-biliary-tract-cancer
#16
Yoshihiro Miyazaki, Takashi Kokudo, Katsumi Amikura, Amane Takahashi, Nobuhiro Ohkohchi, Hirohiko Sakamoto
BACKGROUND: In biliary tract cancer treatment, a precise preoperative evaluation of the patient's liver function is essential to avoid post-hepatectomy liver failure (PHLF) and mortality. The present study aimed to evaluate the role of the Albumin-Indocyanine Green Evaluation (ALICE) grading system in predicting PHLF in biliary tract cancer patients. METHODS: Data from 166 patients who underwent hepatectomy for biliary tract cancer between 2000 and 2016 were retrospectively analyzed...
January 16, 2018: Digestive Surgery
https://www.readbyqxmd.com/read/29339358/family-history-of-cancer-and-risk-of-biliary-tract-cancers-results-from-the-biliary-tract-cancers-pooling-project
#17
Alison L Van Dyke, Margaret S Langhamer, Bin Zhu, Ruth M Pfeiffer, Demetrius Albanes, Gabriella Andreotti, Laura E Beane Freeman, Andrew T Chan, Neal D Freedman, Susan M Gapstur, Graham G Giles, Francine Grodstein, Linda M Liao, Juhua Luo, Roger L Milne, Kristine R Monroe, Marian L Neuhouser, Jenny N Poynter, Mark P Purdue, Kim Robien, Catherine Schairer, Rashmi Sinha, Stephanie Weinstein, Xuehong Zhang, Jessica L Petrick, Katherine A McGlynn, Peter T Campbell, Jill Koshiol
Background: Although some familial cancer syndromes include biliary tract cancers (BTCs; cancers of the gallbladder, intrahepatic and extrahepatic bile ducts, and ampulla of Vater), the few studies that have examined the relationships between family history of cancer (FHC) and BTCs have reported inconclusive findings. The objective of this study was to investigate the associations of FHC with risk of BTC in the Biliary Tract Cancers Pooling Project (BiTCaPP). Methods: We used Cox proportional hazards regressions models to estimate HRs and 95% confidence intervals for associations between FHC (any, first-degree, in female relative, in male relative, relative with gastrointestinal cancer, and relative with hormonally related cancer) and BTC risk by anatomic site within the biliary tract, adjusting for sex and race/ethnicity...
March 2018: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/29315013/on-the-evolution-of-bile-salts-and-the-farnesoid-x-receptor-in-vertebrates
#18
Kim Frisch, Aage Kristian Olsen Alstrup
In recent decades, our knowledge of bile salts has undergone a vast development, and bile salts are now known not only for their detergent properties that aid in the absorption of dietary lipids but also for their interaction with specific nuclear and membrane receptors. In particular, it has been realized that the response of the farnesoid X receptor (FXR) to bile acids provides a signal bridge between the liver and small intestine, controlling the intracellular levels, biosynthesis, and enterohepatic circulation of bile acids...
March 2018: Physiological and Biochemical Zoology: PBZ
https://www.readbyqxmd.com/read/29307199/pathologic-classification-of-pancreatic-cancers-current-concepts-and-challenges
#19
Mohamed E Mostafa, Ipek Erbarut-Seven, Burcin Pehlivanoglu, Volkan Adsay
As the most common and most important cancer of the pancreas, with rapid mortality and now also as the third leading cause of cancer-related deaths in the United States, pancreatic ductal adenocarcinoma (PDAC) has become synonymous with "pancreas cancer". PDAC is also the prototype of the "pancreatobiliary-type" adenocarcinomas, along the biliary tract, ampullary and gallbladder cancers with the similar morphology and behavior. Recent molecular profiling studies have identified distinct subsets of PDAC, potentially with different behaviors and targetability...
December 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/29207941/uneven-acute-non-alcoholic-fatty-change-of-the-liver-after-percutaneous-transhepatic-portal-vein-embolization-in-a-patient-with-hilar-cholangiocarcinoma-a-case-report
#20
Chun-Yi Tsai, Motoi Nojiri, Yukihiro Yokoyama, Tomoki Ebata, Takashi Mizuno, Masato Nagino
BACKGROUND: Portal vein embolization is essential for patients with biliary cancer who undergo extended hepatectomy to induce hypertrophy of the future remnant liver. Over 830 patients have undergone the portal vein embolization at our institution since 1990. Non-alcoholic fatty liver disease is an entity of hepatic disease characterized by fat deposition in hepatocytes. It has a higher prevalence among persons with morbid obesity, type 2 diabetes, and hyperlipidemia. Neither the mechanism of hepatic hypertrophy after portal vein embolization nor the pathophysiology of non-alcoholic fatty liver disease has been fully elucidated...
December 6, 2017: BMC Gastroenterology
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