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Tendon injections

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https://www.readbyqxmd.com/read/29156445/autologous-tenocyte-implantation-into-shoulder-tendon-pathology-in-an-elite-swimmer
#1
Laura M Schwab, Peter Blanch, Mark Young
INTRODUCTION: The use of novel bioengineer treatment techniques such as Autologous Tenocyte Implantation (ATI) have shown promising improvements in both pain ratings and functional outcomes in elbow, gluteal and shoulder tendon pathology. This case will review the injury timeline of ATI intervention in an elite male swimmer with subscapularis tendon pathology and investigate whether ATI has a concomitant healing effect associated with improved functional outcomes. METHODS: A palmaris longus tendon biopsy was performed and cells were expanded by in-vitro culture...
October 13, 2017: Physical Therapy in Sport
https://www.readbyqxmd.com/read/29150470/platelet-rich-plasma-in-achilles-tendon-healing-2-path-2-trial-protocol-for-a-multicentre-participant-and-assessor-blinded-parallel-group-randomised-clinical-trial-comparing-platelet-rich-plasma-prp-injection-versus-placebo-injection-for-achilles-tendon-rupture
#2
Joseph Alsousou, David J Keene, Philippa A Hulley, Paul Harrison, Susan Wagland, Christopher Byrne, Michael Maia Schlüssel, Susan J Dutton, Sarah E Lamb, Keith Willett
BACKGROUND: Achilles tendon injuries give rise to substantial long-lasting morbidity and pose considerable challenges for clinicians and patients during the lengthy healing period. Current treatment strategies struggle to curb the burden of this injury on health systems and society due to lengthy rehabilitation, work absence and reinjury risk. Platelet-rich plasma (PRP) is an autologous preparation that has been shown to improve the mechanobiological properties of tendons in laboratory and animal studies...
November 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/29125382/intra-sheath-versus-extra-sheath-ultrasound-guided-corticosteroid-injection-for-trigger-finger-a-triple-blinded-randomized-clinical-trial
#3
Mohsen Mardani-Kivi, Mahmoud Karimi-Mobarakeh, Ali Babaei Jandaghi, Sohrab Keyhani, Khashayar Saheb-Ekhtiari, Keyvan Hashemi-Motlagh
OBJECTIVE: The aim of this study is to compare clinical results of ultrasound-guided corticosteroid injection, intra-sheath versus extra-sheath of the finger flexor tendon. METHODS: A total of 166 patients with trigger finger were evaluated in a triple blind randomized clinical trial study. All the patients were injected with 1ml of 40mg/ml methyl prednisolone acetate, under the guidance of ultrasound. Half the patients were injected extra sheath, while the other half were injected intra sheath at the level of first annular pulley...
November 10, 2017: Physician and Sportsmedicine
https://www.readbyqxmd.com/read/29118985/acute-development-of-cushing-syndrome-in-an-hiv-infected-child-on-atazanavir-ritonavir-based-antiretroviral-therapy
#4
Gueorgui Dubrocq, Andrea Estrada, Shannon Kelly, Natella Rakhmanina
An 11-year-old male with perinatally acquired human immune deficiency virus (HIV) infection on antiretroviral regimen, which included abacavir plus lamivudine (Epzicom), didanosine, ritonavir and atazanavir presented with bilateral axillary striae, increased appetite, fatigue, facial swelling and acute weight gain. Two months prior to presentation, the patient had received a diagnostic and therapeutic intra-articular triamcinolone injection in the knee for pain relief and subsequently became progressively swollen in the face, developed striae bilaterally at the axillae, experienced increased appetite, fatigue and an 8 pound weight gain...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29108884/peritendinous-injection-of-platelet-rich-plasma-to-treat-tendinopathy-a-retrospective-review
#5
Mehmet Can Unlu, Aybars Kivrak, Mahmut Enes Kayaalp, Olgar Birsel, Isık Akgun
OBJECTIVE: The aim of this study was to determine factors associated with the likelihood of a better clinical outcome after the peritendinous injection of PRP for the treatment of chronic tendinopathy and identify whether PRP represents an effective treatment option for chronic tendinopathies. METHODS: The study included 214 patients (86 males and 128 females; mean age: 39.3 (18-75) years) who received PRP injections for tendinopathy refractory to conventional treatments...
November 3, 2017: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/29099894/effects-of-platelet-rich-plasma-and-indomethacin-on-biomechanics-of-rotator-cuff-repair
#6
Molly C Meadows, David M Levy, Christopher M Ferry, Thomas R Gardner, Takeshi Teratani, Christopher S Ahmad
We conducted a study to determine if platelet-rich plasma (PRP) enhances the strength of rotator cuff repair (RCR) and if concomitant use of nonsteroidal anti-inflammatory drugs (NSAIDs) affects PRP efficacy. We also wanted to determine the optimal centrifugation protocol for making PRP from rats. This study used 48 rats, 14 in a centrifugation protocol and 34 in an operative protocol. Six syngeneic rats from the operative group were used as PRP blood donors; the other 28 operative rats underwent bilateral RCRs...
September 2017: American Journal of Orthopedics
https://www.readbyqxmd.com/read/29077497/rupture-of-the-extensor-hallucis-longus-muscle-secondary-to-repetitive-overuse-in-a-taekwondo-athletea-case-report
#7
Dong-Il Chun, Jun-Hyuck Lee, Jaeho Cho
Closed rupture of the extensor hallucis longus (EHL) tendon is rare, with most cases caused by either direct penetrating trauma or predisposing factors such as corticosteroid injection and iatrogenic trauma incidences. Almost all of the previous case reports have reported on rupture of the EHL tendon rather than the EHL muscle. In this report, we highlight an unusual clinical presentation of a rupture of the EHL muscle and discuss its predisposing factors. This patient was a taekwondo athlete with EHL muscle rupture secondary to repetitive overuse without any underlying systemic or local predisposing factors or direct trauma...
September 2017: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/29069005/effect-of-polydeoxyribonucleotide-injection-on-pes-anserine-bursitis-a-case-report
#8
Jong-Uk Mun, Hyung R Cho, Sae M Bae, Soo K Park, Soo L Choi, Mi S Seo, Young S Lim, Soo H Woo Rn, Young U Kim
RATIONALE: Pes anserine (PA) bursitis is an inflammatory condition of the medial knee. The PA bursa becomes more painful when infected, damaged, or irritated. Although various treatment options have been attempted to treat PA bursitis, optimal treatments are still debated. This study aims to investigate the effect of polydeoxyribonucleotide (PDRN) injection on reducing pain and inflammation in a patient presenting with PA bursitis. PATIENT CONCERNS: A 50-year-old female patient was admitted to our pain clinic with symptoms of tenderness and pain over the medial knee...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29067288/gene-therapy-using-plasmid-dna-encoding-vascular-endothelial-growth-factor-164-and-fibroblast-growth-factor-2-genes-for-the-treatment-of-horse-tendinitis-and-desmitis-case-reports
#9
Milomir Kovac, Yaroslav A Litvin, Ruslan O Aliev, Elena Yu Zakirova, Catrin S Rutland, Andrey P Kiyasov, Albert A Rizvanov
In this clinical study, for the first time we used the direct gene therapy to restore severe injuries of the suspensory ligament branch and superficial digital flexor tendon in horses (Equus caballus). We injected the plasmid DNA encoding two therapeutic species-specific growth factors: vascular endothelial growth factor 164 and fibroblast growth factor 2 at the site of injury in the suspensory ligament branch and tendon. Treatment effects were evaluated with the use of clinical observation and ultrasound imaging during a period of a few months...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29067092/effect-of-tendon-hydrogel-on-healing-of-tendon-injury
#10
Zheng Chen, Yongjun Rui, Yajun Xu, Quanrong Zhang, Zhenzhong Sun, Jiandong Zhou, Xueming Chen
Hand trauma arising from postoperative acute or chronic tendon injuries leads to delayed union and is one of the greatest challenges in clinical practice. The present study hypothesized that an extracellular matrix hydrogel made from tendons can promote tendon healing and improve tissue regeneration. To verify this, 36 Wistar rats were subjected to bilateral full-thickness injury of their Achilles tendons, starting from the heel bone along the center line to remove a segment of 5 mm in length and 0.5 mm in width...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29027640/the-utility-of-botulinum-toxin-a-in-the-repair-of-distal-biceps-tendon-ruptures
#11
L S Khalil, R A Keller, N Mehran, N E Marshall, K Okoroha, N B Frisch, S P DeSilva
PURPOSE: The purpose of our study is to report the outcomes and complications in patients who underwent distal biceps tendon repair with the use of Botulinum toxin A (BoNT-A) as an adjunct to surgery. METHODS: A retrospective review of 14 patients who underwent 15 distal biceps tendon repairs was performed. All repaired tendons had their correlating muscle bellies injected intraoperatively with a mixture of 100U of BoNT-A and 10 ml of normal saline. Each patient was evaluated for surgical and post-operative complications and followed with Disabilities of the Arm, Shoulder and Hand (DASH) Disability Scores...
October 13, 2017: Musculoskeletal Surgery
https://www.readbyqxmd.com/read/29027573/dose-reduction-for-fluoroscopically-guided-injections-phantom-simulation-and-patient-procedures
#12
C Y Chang, F J Simeone, M C DeLorenzo, W E Palmer, M A Bredella, A J Huang
OBJECTIVE: To demonstrate fluoroscopy dose reduction through both simulated injections on a phantom and patient injections. MATERIALS AND METHODS: Our study was IRB-approved and HIPAA-compliant. Simulation on a phantom was used to estimate effective dose, entrance dose, and organ doses for hip joint injections without and with dose minimization technique (DMT). Additionally, 1,094 joint, bursae, and tendon sheath injections performed by three operators in the same fluoroscopy suite were evaluated both before and after application of DMT...
October 13, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/29027008/lateral-epicondylitis-associations-of-mr-imaging-and-clinical-assessments-with-treatment-options-in-patients-receiving-conservative-and-arthroscopic-managements
#13
Ji Young Jeon, Min Hee Lee, In-Ho Jeon, Hye Won Chung, Sang Hoon Lee, Myung Jin Shin
OBJECTIVES: We assessed the implications of MR imaging with clinical history in lateral epicondylitis management by evaluating imaging and clinical features in patients with lateral epicondylitis treated conservatively or operatively. METHODS: Sixty patients with lateral epicondylitis treated conservatively (n = 38) or operatively (n = 22) from 2011-2015 were included. MR imaging findings of common extensor tendon (CET), lateral collateral ligament (LCL) complex, muscle oedema, ulnar nerve and elbow joint were reviewed...
October 12, 2017: European Radiology
https://www.readbyqxmd.com/read/29026332/ultrasound-guided-methotrexate-injection-for-de-quervain-disease-of-the-wrist-what-lies-beyond-the-horizon
#14
Abdallah El-Sayed Allam, Doaa Shawky Al-Ashkar, Ahmed A Negm, Basma Aly Eltawab, Wei-Ting Wu, Ke-Vin Chang
De Quervain disease (DQVD) is one of the most common causes of lateral wrist pain and can lead to significant disability. The current case involves a right-handed, middle-aged, female patient with severe lateral wrist pain due to DQVD. Her pain was not responsive to oral non-steroidal anti-inflammatory drugs, rehabilitation, and repeated corticosteroid injections. Because she refused surgical intervention, we performed ultrasound-guided methotrexate injections (four times). After the injections, dramatic pain relief, functional improvement, and reduction of the thickness of the retinaculum and tendons in the first dorsal extensor compartment of the wrist were noted...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/29026107/achilles-tendon-compositional-and-structural-properties-are-altered-after-unloading-by-botox
#15
Hanifeh Khayyeri, Parmis Blomgran, Malin Hammerman, Mikael J Turunen, Annika Löwgren, Manuel Guizar-Sicairos, Per Aspenberg, Hanna Isaksson
Tendon function and homeostasis rely on external loading. This study investigates the biological mechanisms behind tendon biomechanical function and how the mechanical performance is affected by reduced daily loading. The Achilles tendons of 16 weeks old female Sprague Dawley rats (n = 40) were unloaded for 5 weeks by inducing muscle paralysis with botulinum toxin injections in the right gastrocnemius and soleus muscles. The contralateral side was used as control. After harvest, the tendons underwent biomechanical testing to assess viscoelasticity (n = 30 rats) and small angle X-ray scattering to determine the structural properties of the collagen fibrils (n = 10 rats)...
October 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29020874/safety-of-corticosteroid-injection-for-carpal-tunnel-syndrome
#16
Emma Kaile, Jeremy D P Bland
The risks of corticosteroid injection for carpal tunnel syndrome, principally intraneural injection and tendon rupture, are known only from anecdotal reports. The literature does not allow an accurate estimate of their incidence or that of lesser side effects such as local pain. We have encountered only four serious complications in 9515 injections. We asked patients about possible side effects at routine follow-up, 6 weeks after 689 injections with 40 mg triamcinolone. Possible side effects were reported after 33% of injections...
January 1, 2017: Journal of Hand Surgery, European Volume
https://www.readbyqxmd.com/read/29018808/tenogenically-induced-allogeneic-peripheral-blood-mesenchymal-stem-cells-in-allogeneic-platelet-rich-plasma-2-year-follow-up-after-tendon-or-ligament-treatment-in-horses
#17
Charlotte Beerts, Marc Suls, Sarah Y Broeckx, Bert Seys, Aurélie Vandenberghe, Jeroen Declercq, Luc Duchateau, Martin A Vidal, Jan H Spaas
Poor healing of tendon and ligament lesions often results in early retirement of sport horses. Therefore, regenerative therapies are being explored as potentially promising treatment for these injuries. In this study, an intralesional injection was performed with allogeneic tenogenically induced mesenchymal stem cells and platelet-rich plasma 5-6 days after diagnosis of suspensory ligament (SL) (n = 68) or superficial digital flexor tendon (SDFT) (n = 36) lesion. Clinical, lameness and ultrasonographic evaluation was performed at 6 and 12 weeks...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28987658/magnetic-resonance-and-ultrasound-in-achilles-tendinopathy-predictive-role-and-response-assessment-to-platelet-rich-plasma-and-adipose-derived-stromal-vascular-fraction-injection
#18
Domenico Albano, Carmelo Messina, Federico Giuseppe Usuelli, Laura De Girolamo, Miriam Grassi, Camilla Maccario, Bianca Bignotti, Alberto Tagliafico, Luca Maria Sconfienza
OBJECTIVE: To assess the correlation between magnetic resonance and ultrasound findings and clinical outcome after intratendinous injection of leucocyte-rich platelet-rich plasma or adipose-derived stromal vascular fraction in patients with non-insertional Achilles tendinopathy. MATERIALS AND METHODS: Forty-three patients (age: 47.8±5.1, range 29-55) with unilateral or bilateral non-insertional Achilles tendinopathy (58 tendons overall) were randomly assigned to platelet-rich plasma (22 patients, 28 tendons) or adipose-derived stromal vascular fraction (21 patients, 30 tendons) injection group...
October 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28986619/-therapeutic-utilization-of-stem-cells-in-orthopedics
#19
C Chiari, S Walzer, D Stelzeneder, M Schreiner, R Windhager
Stem cells are becoming increasingly more important in the field of regenerative medicine. Adult mesenchymal stem cells (MSCs) are harvested predominantly from bone marrow or adipose tissue, are already being used in the clinical setting and have a low potential for side effects. In orthopedics, experience has been gained in the treatment of bone defects, non-unions, cartilage defects, osteoarthritis and tendon pathologies. The current data are derived from case studies and randomized controlled trials are missing; therefore, there are many open questions concerning the optimal cell source, number of cells, administration technique (e...
October 6, 2017: Der Orthopäde
https://www.readbyqxmd.com/read/28980027/-insertional-achilles-tendinopathy-differentiated-diagnostics-and-therapy
#20
REVIEW
S F Baumbach, M Braunstein, M G Mack, F Maßen, W Böcker, S Polzer, H Polzer
Achilles tendinopathy at the calcaneal insertion is classified into insertional tendinopathy, retrocalcaneal and superficial bursitis. The aim of this study was to present the current evidence on conservative and surgical treatment of insertional tendinopathy of the Achilles tendon. Conservative first-line therapy includes reduction of activity levels, administration of non-steroidal anti-inflammatory drugs (NSAID), adaptation of footwear, heel wedges and orthoses or immobilization. In addition, further conservative therapy options are also available...
October 4, 2017: Der Unfallchirurg
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