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https://www.readbyqxmd.com/read/28921035/-midportion-achilles-tendinopathy
#1
REVIEW
J Weber, T Buchhorn
Although the incidence of midportion Achilles tendinopathy is under 1% in the general population, it is quite a common disease in runners that is characterized by the symptom triad of pain, swelling and impaired physical performance. Pain and swelling are located in the area 2 to 7 cm proximal the tendon insertion onto the calcaneus.Diagnosis is made by adequate clinical symptoms and corresponding findings in sonography and/or magnetic resonance imaging scans. Histopathologically, mostly degenerative changes in the tendon structure are found, sometimes accompanied by intra- and paratendinous inflammation...
September 18, 2017: Der Unfallchirurg
https://www.readbyqxmd.com/read/28919215/thermo-responsive-in-situ-forming-hydrogels-as-barriers-to-prevent-post-operative-peritendinous-adhesion
#2
Pang-Yun Chou, Shih-Heng Chen, Chih-Hao Chen, Shih-Hsien Chen, Yi Teng Fong, Jyh-Ping Chen
In this study, we aimed to assess whether thermo-responsive in-situ forming hydrogels based on poly(N-isopropylacrylamide) (PNIPAM) could prevent post-operative peritendinous adhesion. The clinical advantages of the thermo-responsive hydrogels are acting as barrier material to block penetration of fibroblasts, providing mobility and flexibility during application and enabling injection through a small opening to fill spaces of any shape after surgery. The thermo-responsiveness of hydrogels was determined to ensure their clinic uses...
September 12, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28902035/small-particle-hyaluronic-acid-gel-treatment-of-photoaged-hands
#3
Eric C Wilkerson, David J Goldberg
BACKGROUND: Aging hands tend to lose subcutaneous volume resulting in prominence of the underlying vessels, tendons, and bone contributing to an aged appearance. Dermal fillers have been successfully used to improve the appearance of the aging dorsal hand. OBJECTIVE: The objective is to evaluate the safety and efficacy of a small-particle hyaluronic acid (SPHA) injectable gel for the treatment of photoaged volume loss of the hands. MATERIALS AND METHODS: This is an open-label, prospective, randomized, interventional, study...
September 4, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28884594/predicting-failure-of-nonoperative-treatment-for-insertional-achilles-tendinosis
#4
James F Stenson, Christopher W Reb, Joseph N Daniel, Sundeep S Saini, Mohammed F Albana
Nonoperative treatment for midportion Achilles tendinosis is well defined by the literature. Multiple modalities are described for the management of insertional Achilles pathology, but no consensus exists regarding efficacy. Surgical intervention for insertional Achilles tendinosis (IAT) is successful greater than 80% of the time. Our objective was to risk stratify patients who would fail nonsurgical management of IAT and thus benefit progressing to surgery. We reviewed the records of 664 patients with IAT...
September 1, 2017: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/28880113/increasing-age-and-tear-size-reduce-rotator-cuff-repair-healing-rate-at-1-year
#5
Mustafa S Rashid, Cushla Cooper, Jonathan Cook, David Cooper, Stephanie G Dakin, Sarah Snelling, Andrew J Carr
Background and purpose - There is a need to understand the reasons why a high proportion of rotator cuff repairs fail to heal. Using data from a large randomized clinical trial, we evaluated age and tear size as risk factors for failure of rotator cuff repair. Patients and methods - Between 2007 and 2014, 65 surgeons from 47 hospitals in the National Health Service (NHS) recruited 447 patients with atraumatic rotator cuff tendon tears to the United Kingdom Rotator Cuff Trial (UKUFF) and 256 underwent rotator cuff repair...
September 7, 2017: Acta Orthopaedica
https://www.readbyqxmd.com/read/28872895/hyaluronic-acid-accelerates-tendon-to-bone-healing-after-rotator-cuff-repair
#6
Hirokazu Honda, Masafumi Gotoh, Tomonoshin Kanazawa, Hiroki Ohzono, Hidehiro Nakamura, Keisuke Ohta, Kei-Ichiro Nakamura, Kanji Fukuda, Takeshi Teramura, Takashi Hashimoto, Shigeki Shichijo, Naoto Shiba
BACKGROUND: There is growing evidence that the subacromial injection of hyaluronic acid (HA) is effective for pain relief in rotator cuff tears; however, its effect on tendon-to-bone healing remains unknown. PURPOSE: To examine the effect of HA on the chondrogenesis of mesenchymal stem cells (MSCs) in vitro and on tendon-to-bone healing in a rotator cuff repair model. STUDY DESIGN: Controlled laboratory study. METHODS: Bilateral complete tears of the infraspinatus tendon were made in rabbits and subsequently repaired...
September 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28870061/morphological-alterations-of-the-tendon-and-pulley-on-ultrasound-after-intrasynovial-injection-of-betamethasone-for-trigger-digit
#7
Mitsuhiko Takahashi, Ryosuke Sato, Kenji Kondo, Koichi Sairyo
Purpose: The aim of this study was to elucidate whether intrasynovial corticosteroid injections for trigger digit reduced the volume of the tendon and pulley on high-resolution ultrasonography. Methods: Twenty-three digits of 20 patients with trigger digit were included. Each affected finger was graded clinically according to the following classification: grade I for pre-triggering, grade II for active triggering, grade III for passive triggering, and grade IV for presence of contracture...
July 25, 2017: Ultrasonography
https://www.readbyqxmd.com/read/28854761/platelet-rich-plasma-injections-as-a-treatment-for-refractory-patellar-tendinosis-a-meta-analysis-of-randomised-trials
#8
REVIEW
Leanne Dupley, Charalambos P Charalambous
Purpose: Patellar tendinosis (PT) is a common condition amongst athletes. In this study, we perform a meta-analysis on randomised controlled trials (RCTs) to evaluate the use of platelet-rich plasma (PRP) for refractory PT. Methods: A literature search was undertaken in various databases from their year of inception to October 2015. The primary outcome measure was the Victorian Institute of Sports Assessment-Patella (VISA-P) score. Results: We identified 2 RCTs comparing PRP injections to alternative treatment options (extracorporeal shockwave therapy [ESWT] and dry needling of the tendon)...
September 1, 2017: Knee Surgery & related Research
https://www.readbyqxmd.com/read/28832214/painful-pseudotendon-of-the-flexor-carpi-radialis-tendon-a-literature-review-and-case-report
#9
Robert E Van Demark, Elizabeth Helsper, Meredith Hayes, Matthew Hayes, Vanessa J S Smith
BACKGROUND: Flexor tendon ruptures in the wrist are uncommon. Flexor carpi radialis (FCR) tendon rupture can occur in rheumatoid patients, following cortisone injection for tenosynovitis, and following trauma. Following tendon rupture, tethering of the ruptured FCR tendon, or pseudotendon, can form which may or may not be symptomatic. METHODS: A literature review was done reviewing treatment and outcomes of FCR tendon lesions. A case report of painful FCR pseudotendon following a fall is presented...
September 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28822690/microrna29a-treatment-improves-early-tendon-injury
#10
Ashlee E Watts, Neal L Millar, Josh Platt, Susan M Kitson, Moeed Akbar, Raquel Rech, Jay Griffin, Roy Pool, Tom Hughes, Iain B McInnes, Derek S Gilchrist
Tendon injuries (tendinopathies) are common in human and equine athletes and characterized by dysregulated collagen matrix, resulting in tendon damage. We have previously demonstrated a functional role for microRNA29a (miR29a) as a post-transcriptional regulator of collagen 3 expression in murine and human tendon injury. Given the translational potential, we designed a randomized, blinded trial to evaluate the potential of a miR29a replacement therapy as a therapeutic option to treat tendinopathy in an equine model that closely mimics human disease...
July 28, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28821728/dynamic-weight-bearing-analysis-is-effective-for-evaluation-of-tendinopathy-using-a-customized-corridor-with-multi-directional-force-sensors-in-a-rat-model
#11
Po-Ting Wu, Chieh-Hsiang Hsu, Fong-Chin Su, I-Ming Jou, Shih-Yao Chen, Chao-Liang Wu, Wei-Ren Su, Li-Chieh Kuo
Few studies discuss kinetic changes in tendinopathy models. We propose a customized corridor to evaluate dynamic weight bearing (DWB) and shearing forces. Sixty rats were randomly given ultrasound-assisted collagenase injections (Collagenase rats) or needle punctures (Control rats) in their left Achilles tendons, and then evaluated 1, 4, and 8 weeks later. The Collagenase rats always had significantly (p < 0.001) higher histopathological and ultrasound feature scores than did the Controls, significantly lower DWB values in the injured than in the right hindlimbs, and compensatorily higher (p < 0...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28806826/-treatment-of-dupuytren-s-disease-with-collagenase-injections-in-germany-efficacy-and-adverse-effects-in-110-treated-joints
#12
Adrian Pototschnig, Elias Volkmer, Riccardo E Giunta
Background Since 2011, a new minimally-invasive treatment for Dupuytren's disease has been available in the form of injectable collagenase (Xiapex®, Pfizer). Purpose Our aim is to report about the results and adverse effects of injectable collagenase for the treatment of Dupuytren's disease in Germany. Patients and Methods We treated 78 patients (61 male, 17 female) with 87 injections in 87 digits (little finger n = 40, ring finger n = 37, middle finger n = 8 and index n = 2). We documented the range of motion before treatment, after 6 weeks and after 6 months...
August 2017: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
https://www.readbyqxmd.com/read/28806095/a-midterm-evaluation-of-postoperative-platelet-rich-plasma-injections-on-arthroscopic-supraspinatus-repair-a-randomized-controlled-trial
#13
Jay R Ebert, Allan Wang, Anne Smith, Robert Nairn, William Breidahl, Ming Hao Zheng, Timothy Ackland
BACKGROUND: Platelet-rich plasma (PRP) has been applied as an adjunct to rotator cuff repair to improve tendon-bone healing and potentially reduce the incidence of subsequent tendon retears. PURPOSE: To investigate whether the midterm clinical and radiographic outcomes of arthroscopic supraspinatus repair are enhanced after repeated postoperative applications of PRP. STUDY DESIGN: Randomized controlled trial; Level of evidence, 1. METHODS: A total of 60 patients (30 control; 30 PRP) were initially randomized to receive 2 ultrasound-guided injections of PRP to the tendon repair site at 7 and 14 days after double-row arthroscopic supraspinatus repair or not...
August 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28774238/wide-awake-hand-surgery
#14
Line Lied, Grethe E Borchgrevink, Vilhjalmur Finsen
BACKGROUND: "Wide awake hand surgery", where surgery is performed in local anaesthesia with adrenaline, without sedation or a tourniquet, has become widespread in some countries. It has a number of potential advantages and we wished to evaluate it among our patients. METHODS: All 122 patients treated by this method during one year were evaluated by the surgeons and the patients on a numerical scale from 0 (best/least) to 10 (worst/most). Theatre time was compared to that recorded for a year when regional or general anaesthesia had been used...
September 2017: Journal of Hand Surgery Asian-Pacific Volume
https://www.readbyqxmd.com/read/28774233/disruption-of-flexor-tendon-after-intrasheath-triamcinolone-acetonide-injection-for-trigger-digits-two-case-reports
#15
Toshikazu Tanaka, Takeshi Ogawa, Takaji Yanai, Eriko Okano, Sho Kohyama, Naoyuki Ochiai
We experienced two cases of flexor tendons rupture after triamcinolone acetate (TA) injection for trigger finger. A 45-year-old man underwent injection of 40 mg of TA and 1 mL of 1% lidocaine solution into his little finger. While playing golf 3 months after the injection, he heard a popping sound, and was unable to flex it. A 57-year-old female nurse had undergone injection of 40 mg of TA and 1 mL of 1% lidocaine solution into her thumb twice at a 2-month interval. Two months after the second injection, she was unable to flex it...
September 2017: Journal of Hand Surgery Asian-Pacific Volume
https://www.readbyqxmd.com/read/28771237/mechanical-isolation-and-measurement-of-force-and-myoplasmic-free-ca-2-in-fully-intact-single-skeletal-muscle-fibers
#16
Arthur J Cheng, Håkan Westerblad
Mechanical dissection of single intact mammalian skeletal muscle fibers permits real-time measurement of intracellular properties and contractile function of living fibers. A major advantage of mechanical over enzymatic fiber dissociation is that single fibers can be isolated with their tendons remaining attached, which allows contractile forces (in the normal expected range of 300-450 kN/m(2)) to be measured during electrical stimulation. Furthermore, the sarcolemma of single fibers remains fully intact after mechanical dissection, and hence the living fibers can be studied with intact intracellular milieu and normal function and metabolic properties, as well as ionic control...
September 2017: Nature Protocols
https://www.readbyqxmd.com/read/28765268/the-achilles-tendon-and-the-retrocalcaneal-bursa-an-anatomical-and-radiological-study
#17
P A Pękala, B M Henry, J R Pękala, K Piska, K A Tomaszewski
OBJECTIVES: Inflammation of the retrocalcaneal bursa (RB) is a common clinical problem, particularly in professional athletes. RB inflammation is often treated with corticosteroid injections however a number of reports suggest an increased risk of Achilles tendon (AT) rupture. The aim of this cadaveric study was to describe the anatomical connections of the RB and to investigate whether it is possible for fluid to move from the RB into AT tissue. METHODS: A total of 20 fresh-frozen AT specimens were used...
July 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28763326/point-of-care-ultrasonography-findings-and-care-use-among-patients-undergoing-ultrasound-guided-shoulder-injections
#18
Se Won Lee, Timothy Tiu, Jeremy Roberts, Brian Lee, Matthew N Bartels, Mooyeon Oh-Park
OBJECTIVE: The aims of the study were to assess the overall reduction of pain in patients undergoing ultrasound-guided shoulder injections and to characterize the preinjection point-of-care ultrasound findings and use of clinical services postinjection including the use of magnetic resonance imaging and surgeries. DESIGN: Data of 172 patients who underwent ultrasound-guided subacromial subdeltoid injection or glenohumeral joint injection were reviewed for preinjection point-of-care ultrasound findings, change in pain intensity at 2 mos from baseline, and use of care at 6 mos' postinjection...
August 1, 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/28761625/effects-of-redox-modulation-on-cell-proliferation-viability-and-migration-in-cultured-rat-and-human-tendon-progenitor-cells
#19
Yuk Wa Lee, Sai Chuen Fu, Man Yi Yeung, Chun Man Lawrence Lau, Kai Ming Chan, Leung Kim Hung
Tendon healing is slow and usually results in inferior fibrotic tissue formation. Recently, application of tendon derived stem cells (TDSCs) improved tendon healing in animal studies. In a chicken model, local injection of antioxidants reduced tendon adhesion after tendon injury. An in vitro study demonstrated that supplementation of H2O2 reduced tenogenic marker expression in TDSCs. These findings suggested that the possibility of TDSCs is involved in tendon healing and the cellular activities of TDSCs might be affected by oxidative stress of the local environment...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28760374/ropivacaine-alters-the-mechanical-properties-of-hamstring-tendons-in-vitro-controlled-mechanical-testing-of-tendons-from-living-donors
#20
Matthieu Ollivier, Jaafar Sbihi, Abderrahmane Sbihi, Martine Pithioux, Sebastien Parratte, Jean-Noel Argenson
OBJECTIVE: Intra-articular or peri-articular injection of ropivacaine (RI) is an element of current knee surgery practices. The goal of this study was to determine the effects of RI on the mechanical properties of hamstring tendons. METHODS: A tensile test to failure was performed on 120 hamstring tendon segments harvested during ACL reconstruction surgery in 120 patients. Two sets of tensile tests were done. The first evaluated the effect of RI itself on the mechanical properties of tendons: 30 samples were soaked for 1 hour in a 2% RI solution and compared to 30 samples soaked in a saline solution (control group)...
July 28, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
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