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Luminal a breast cancer radiation liu

Quanquan Sun, Tongxin Liu, Yawei Yuan, Zhenli Guo, Guozhu Xie, Shasha Du, Xiaoshan Lin, Zhixin Xu, Minfeng Liu, Wei Wang, Quan Yuan, Longhua Chen
Radioresistance is a major challenge during the treatment of breast cancer. A further understanding of the mechanisms of radioresistance could provide strategies to address this challenge. In our study, we compared the expression of miR-200c in four distinct breast cancer cell lines: two representative basal cancer cells (MDA-MB-231 and BT549) vs. two representative luminal cancer cells (MCF-7 and BT474). The results revealed practically lower expression of miR-200c in the two basal cancer cell lines and higher expression of miR-200c in luminal cancer cells compared to the normal breast epithelial cell line MCF-10A...
March 1, 2015: International Journal of Cancer. Journal International du Cancer
Tyler J W Robinson, Jeff C Liu, Frederick Vizeacoumar, Thomas Sun, Neil Maclean, Sean E Egan, Aaron D Schimmer, Alessandro Datti, Eldad Zacksenhaus
Triple negative breast cancer (TNBC) includes basal-like and claudin-low subtypes for which only chemotherapy and radiation therapy are currently available. The retinoblastoma (RB1) tumor suppressor is frequently lost in human TNBC. Knockdown of RB1 in luminal BC cells was shown to affect response to endocrine, radiation and several antineoplastic drugs. However, the effect of RB1 status on radiation and chemo-sensitivity in TNBC cells and whether RB1 status affects response to divergent or specific treatment are unknown...
2013: PloS One
Wen-Chin Hsu, Chan-Cheng Liu, Fu Chang, Su-Shing Chen
UNLABELLED: HASH(0x3f7a3a0) BACKGROUND: Cancer therapy is a challenging research area because side effects often occur in chemo and radiation therapy. We intend to study a multi-targets and multi-components design that will provide synergistic results to improve efficiency of cancer therapy. METHODS: We have developed a general methodology, AMFES (Adaptive Multiple FEature Selection), for ranking and selecting important cancer biomarkers based on SVM (Support Vector Machine) classification...
2012: Journal of Clinical Bioinformatics
K S Kang, W Sun, K Nomata, I Morita, A Cruz, C J Liu, J E Trosko, C C Chang
Ionizing radiation is the exogenous agent best proven to induce breast cancer. c-erbB2/neu amplification and overexpression are known to occur in breast cancer and are correlated with aggressive tumor growth and poor prognosis. We have developed simian virus 40-immortalized cell lines from normal human breast epithelial cells (HBECs) with luminal and stem-cell characteristics. In this study, we examined whether x-rays and a mutated neu oncogene are capable of inducing tumorigenicity in these cells. The results indicated that x-rays were effective in converting immortal non-tumorigenic HBECs to weakly tumorigenic cells that then could be transformed to highly tumorigenic cells by the neu oncogene...
April 1998: Molecular Carcinogenesis
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