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https://www.readbyqxmd.com/read/29779775/accuracy-of-whole-genome-sequencing-versus-phenotypic-mgit-and-commercial-molecular-tests-for-detection-of-drug-resistant-mycobacterium-tuberculosis-isolated-from-patients-in-brazil-and-mozambique
#1
Cinara Silva Feliciano, Evangelina Inacio Namburete, Jéssica Rodrigues Plaça, Kamila Peronni, Anzaan Dippenaar, Robin Mark Warren, Wilson Araújo Silva, Valdes Roberto Bollela
BACKGROUND: The fast and accurate diagnosis of drug-resistant tuberculosis (DR-TB) is critical to reducing the spread of disease. Although commercial genotypic drug-susceptibility tests (DST) are close to the goal, they are still not able to detect all relevant DR-TB related mutations. Whole genome sequencing (WGS) allows better comprehension of DR-TB with a great discriminatory power. We aimed to evaluate WGS in M. tuberculosis isolates compared with phenotypic and genotypic DST. METHODS: This cross-sectional study evaluated 30 isolates from patients with detected DR-TB in Brazil and Mozambique...
May 2018: Tuberculosis
https://www.readbyqxmd.com/read/29777956/how-do-gender-relations-affect-the-working-lives-of-close-to-community-health-service-providers-empirical-research-a-review-and-conceptual-framework
#2
Rosalind Steege, Miriam Taegtmeyer, Rosalind McCollum, Kate Hawkins, Hermen Ormel, Maryse Kok, Sabina Rashid, Lilian Otiso, Mohsin Sidat, Kingsley Chikaphupha, Daniel Gemechu Datiko, Rukhsana Ahmed, Rachel Tolhurst, Woedem Gomez, Sally Theobald
Close-to-community (CTC) providers have been identified as a key cadre to progress universal health coverage and address inequities in health service provision due to their embedded position within communities. CTC providers both work within, and are subject to, the gender norms at community level but may also have the potential to alter them. This paper synthesises current evidence on gender and CTC providers and the services they deliver. This study uses a two-stage exploratory approach drawing upon qualitative research from the six countries (Bangladesh, Indonesia, Ethiopia, Kenya, Malawi, Mozambique) that were part of the REACHOUT consortium...
May 5, 2018: Social Science & Medicine
https://www.readbyqxmd.com/read/29771786/the-continuum-of-hiv-care-in-rural-mozambique-the-implications-of-hiv-testing-modality-on-linkage-and-retention
#3
Elisa Lopez-Varela, Laura Fuente-Soro, Orvalho Joaquim Augusto, Charfudin Sacoor, Ariel Nhacolo, Esmeralda Karajeanes, Paula Vaz, Denise Naniche
INTRODUCTION: Context-specific improvements in the continuum of HIV care are needed in order to achieve the UNAIDS target of 90-90-90. This study aimed to assess the linkage to and retention in HIV care according to different testing modalities in rural southern Mozambique. METHODS: Adults newly diagnosed with HIV from voluntary counseling and testing (VCT), provider-initiated (PICT) and home-based HIV testing (HBT) services were prospectively enrolled between 2014- 2015 at the Manhiça District...
April 27, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29762688/a-multivariate-genetic-analysis-confirms-rs5010528-in-the-human-leucocyte-antigen-c-locus-as-a-significant-contributor-to-stevens-johnson-syndrome-toxic-epidermal-necrolysis-susceptibility-in-a-mozambique-hiv-population-treated-with-nevirapine
#4
Cinzia Ciccacci, Cristina Politi, Sandro Mancinelli, Fausto Ciccacci, Francesca Lucaroni, Giuseppe Novelli, Maria Cristina Marazzi, Leonardo Palombi, Paola Borgiani
Objectives: Nevirapine is used in developing countries for the treatment of HIV infection, but its use is associated with rare serious adverse reactions such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). Recently, an association between rs5010528 in the human leucocyte antigen (HLA)-C locus and SJS/TEN susceptibility has been described in sub-Saharan populations. Our aim was to verify this association in a population of nevirapine-treated patients from Mozambique...
May 11, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29752836/effect-of-a-diagonal-intervention-on-uptake-of-hiv-and-reproductive-health-services-by-female-sex-workers-in-three-sub-saharan-african-cities
#5
Yves Lafort, Letitia Greener, Faustino Lessitala, Sophie Chabeda, Ross Greener, Mags Beksinska, Peter Gichangi, Sally Griffin, Jenni A Smit, Matthew Chersich, Wim Delva
OBJECTIVES: To enhance uptake of sexual and reproductive health (SRH) services by female sex workers (FSWs), we conducted an implementation study in which we piloted and tested context-specific 'diagonal' interventions, combining vertical, targeted interventions with horizontally improved access to the general health services, in three cities in sub-Saharan Africa. METHODS: We collected indicators of SRH service uptake through face-to-face interviews with approximately 400 FSWs, pre- and post-intervention, in Durban, South Africa; Tete, Mozambique; and Mombasa, Kenya, recruited by respondent-driven sampling...
May 12, 2018: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29746301/effect-of-point-of-care-early-infant-diagnosis-on-antiretroviral-therapy-initiation-and-retention-of-patients-a-cluster-randomised-trial
#6
Ilesh V Jani, Bindiya Meggi, Osvaldo Loquiha, Ocean Tobaiwa, Chishamiso Mudenyanga, Alcina Zitha, Dadirayi Mutsaka, Nedio Mabunda, Adolfo Vubil, Timothy Bollinger, Lara Vojnov, Trevor F Peter
OBJECTIVE: We measured the effect of point-of-care early infant HIV testing on antiretroviral therapy initiation rates and retention in care among infants in Mozambique. DESIGN: A cluster-randomised trial was conducted in 16 primary health care centres providing either on-site point-of-care (POC arm; n = 8) or referred laboratory (SOC arm; n = 8) infant HIV testing. METHODS: The primary outcomes were the proportion of HIV-positive infants initiating antiretroviral therapy within 60 days of sample collection, and the proportion of HIV-positive infants who initiated antiretroviral therapy that were retained in care at 90 days of follow-up...
May 8, 2018: AIDS
https://www.readbyqxmd.com/read/29743113/high-production-of-pro-inflammatory-cytokines-by-maternal-blood-mononuclear-cells-is-associated-with-reduced-maternal-malaria-but-increased-cord-blood-infection
#7
Carlota Dobaño, Tamara Berthoud, Maria Nelia Manaca, Augusto Nhabomba, Caterina Guinovart, Ruth Aguilar, Arnoldo Barbosa, Penny Groves, Mauricio H Rodríguez, Alfons Jimenez, Lazaro M Quimice, John J Aponte, Jaume Ordi, Denise L Doolan, Alfredo Mayor, Pedro L Alonso
BACKGROUND: Increased susceptibility to malaria during pregnancy is not completely understood. Cellular immune responses mediate both pathology and immunity but the effector responses involved in these processes have not been fully characterized. Maternal and fetal cytokine and chemokine responses to malaria at delivery, and their association with pregnancy and childhood outcomes, were investigated in 174 samples from a mother and child cohort from Mozambique. Peripheral and cord mononuclear cells were stimulated with Plasmodium falciparum lysate and secretion of IL-12p70, IFN-γ, IL-2, IL-10, IL-8, IL-6, IL-4, IL-5, IL-1β, TNF, TNF-β was quantified in culture supernatants by multiplex flow cytometry while cellular mRNA expression of IFN-γ, TNF, IL-2, IL-4, IL-6, IL-10 and IL-13 was measured by quantitative PCR...
May 10, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29743037/a-cross-sectional-exploratory-study-of-knowledge-attitudes-and-practices-of-emergency-health-care-providers-in-the-assessment-of-child-maltreatment-in-maputo-mozambique
#8
Liliana Pinto, Adriana Lein, Raquel Mahoque, David W Wright, Scott M Sasser, Catherine A Staton
BACKGROUND: In Mozambique, and other low-income countries (LICs), there is little information on the burden of child maltreatment (CM). Emergency care services (ECS) play an important role in recognizing, treating, and intervening in situations of CM. We aim to identify knowledge, attitudes, and practices regarding CM among health care providers in ECS at Mavalane General Hospital in Maputo, Mozambique. METHODS: This exploratory cross-sectional study evaluates the knowledge, attitudes, and practices of health care providers to diagnose and treat cases of CM...
May 9, 2018: BMC Emergency Medicine
https://www.readbyqxmd.com/read/29742132/hiv-drug-resistance-patterns-in-pregnant-women-using-next-generation-sequence-in-mozambique
#9
María Rupérez, Marc Noguera-Julian, Raquel González, Sonia Maculuve, Rocío Bellido, Anifa Vala, Cristina Rodríguez, Esperança Sevene, Roger Paredes, Clara Menéndez
BACKGROUND: Few data on HIV resistance in pregnancy are available from Mozambique, one of the countries with the highest HIV toll worldwide. Understanding the patterns of HIV drug resistance in pregnant women might help in tailoring optimal regimens for prevention of mother to child transmission of HIV (pMTCT) and antenatal care. OBJECTIVES: To describe the frequency and characteristics of HIV drug resistance mutations (HIVDRM) in pregnant women with virological failure at delivery, despite pMTCT or antiretroviral therapy (ART)...
2018: PloS One
https://www.readbyqxmd.com/read/29737408/molecular-characterization-of-avipoxviruses-circulating-in-mozambique-2016-2018
#10
Lourenço P Mapaco, Zeiss Lacerda, Iolanda V A Monjane, Afonso Sussuro, Gerrit J Viljoen, Giovanni Cattoli, William G Dundon, Sara J Achá
Samples from 45 chickens, two turkeys, one peacock and one quail with symptoms of fowlpox were collected in Mozambique between November 2016 and January 2018. Phylogenetic analysis revealed that the samples contained avipoxviruses belonging to both clade A1 and clade A2. In addition, all of the Clade A1 viruses were positive by PCR for the integration of reticuloendotheliosis virus, while the clade A2 avipoxvirus samples were negative. This study confirms the circulation of clade A1 avipoxviruses in Mozambique in addition to identifying clade A2 for the first time in the country...
May 8, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29733254/antibodies-against-chikungunya-in-northern-mozambique-during-dengue-outbreak-2014
#11
Argentina Muianga, Gabriela Pinto, Marilia Massangaie, Sadia Ali, John Oludele, Almiro Tivane, Kerstin I Falk, Nina Lagerqvist, Eduardo S Gudo
An outbreak of dengue and high densities of Aedes aegypti were reported in 2014 in northern Mozambique, suggesting an increased risk for other arboviruses such as chikungunya virus (CHIKV) in this region. The aim of this study was to investigate the occurrence of CHIKV during an outbreak of dengue virus (DENV) in Pemba city in northern Mozambique in 2014. Febrile patients (n = 146) seeking medical attention at the Pemba Provincial Hospital between March and April 2014 were enrolled in this study. Blood samples from each participant were tested for chikungunya and DENV RNA, IgM and IgG antibodies using PCR and ELISA, respectively...
May 7, 2018: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/29730073/a-profile-of-surgical-burden-and-anaesthesia-services-at-mozambique-s-central-hospital-a-review
#12
REVIEW
J Matthew Kynes, Camila B Walters, Emilia Pinto, Emilia Jeque, Ka Kelly McQueen
BACKGROUND: Surgical and anaesthesia data, including outcomes, remain limited in low-income countries (LIC). This study reviews the surgical burden and anaesthesia services at a tertiary care hospital in Mozambique. METHODS: Information on activities within the department of anaesthesia at XXX Central Hospital for 2014-15 was collected from its annual report and verified by the Chairman of Anaesthesia. Personnel information and health care metrics for the hospital in 2015 were collected and verified by hospital leadership...
May 3, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29721490/impact-of-a-diagonal-intervention-on-uptake-of-sexual-and-reproductive-health-services-by-female-sex-workers-in-mozambique-a-mixed-methods-implementation-study
#13
Yves Lafort, Faustino Lessitala, Malica Sofia Ismael de Melo, Sally Griffin, Matthew Chersich, Wim Delva
Background: Female sex workers (FSWs) have high risks for adverse sexual and reproductive health (SRH) outcomes, yet low access to services. Within an implementation research project enhancing uptake of SRH services by FSWs, we piloted a "diagonal" intervention, which combined strengthening of FSW-targeted services (vertical) with making public health facilities more FSW-friendly (horizontal), and tested its effect. Methods: The study applied a convergent parallel mixed-methods design to assess changes in access to SRH services...
2018: Frontiers in Public Health
https://www.readbyqxmd.com/read/29715266/population-structure-in-argentina
#14
Marina Muzzio, Josefina M B Motti, Paula B Paz Sepulveda, Muh-Ching Yee, Thomas Cooke, María R Santos, Virginia Ramallo, Emma L Alfaro, Jose E Dipierri, Graciela Bailliet, Claudio M Bravi, Carlos D Bustamante, Eimear E Kenny
We analyzed 391 samples from 12 Argentinian populations from the Center-West, East and North-West regions with the Illumina Human Exome Beadchip v1.0 (HumanExome-12v1-A). We did Principal Components analysis to infer patterns of populational divergence and migrations. We identified proportions and patterns of European, African and Native American ancestry and found a correlation between distance to Buenos Aires and proportion of Native American ancestry, where the highest proportion corresponds to the Northernmost populations, which is also the furthest from the Argentinian capital...
2018: PloS One
https://www.readbyqxmd.com/read/29701572/detection-and-phylogenetic-characterization-of-porcine-circovirus-2-from-pigs-in-mozambique
#15
Cláudio J Laisse, Carine K Souza, Paula R Pereira, Cíntia De Lorenzo, Matheus V Bianchi, Lourenço P Mapaco, Saulo P Pavarini, Cláudio W Canal, David Driemeier
Porcine circovirus-associated diseases (PCVADs), caused by porcine circovirus 2 (PCV-2), have a significant economic impact on the swine industry worldwide. In Africa, there is little information, to date, regarding the occurrence of PCV-2, and it has not been reported in Mozambique's swine population. We randomly collected mesenteric lymph nodes ( n = 111) from slaughtered pigs from 9 districts in southern Mozambique. PCV-2 DNA was detected in 54% (62 of 111) of the samples and 78% (23 of 31) of the farms...
May 2018: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/29701075/knowledge-about-hiv-hbv-and-hcv-modes-of-transmission-among-pregnant-women-in-nampula-mozambique
#16
Eusébio Chaquisse, Paula Meireles, Sílvia Fraga, Francisco Mbofana, Henrique Barros
The assessment of pregnant women's knowledge about modes of infections transmission is essential to tailor programs to their needs. This study aimed to assess knowledge about human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV) among pregnant women in Nampula - Mozambique, a high-risk area for sexually transmitted infections. At their first antenatal visit, women were invited to participate and data were collected by trained nurses at six public health facilities. Knowledge about HIV transmission modes was high but relevant misconceptions remained...
April 27, 2018: AIDS Care
https://www.readbyqxmd.com/read/29690045/two-new-oedanomerus-species-from-zimbabwe-coleoptera-scarabaeidae-melolonthinae-tanyproctini
#17
Richard Sehnal
Oedanomerus Waterhouse, 1875 (Coleoptera: Scarabaeidae: Melolonthinae: Tanyproctini) was established for a single species Oedanomerus hirsutus Waterhouse, 1875 from Botswana. Arrow (1936) later described O. longicornis from Zambia and Frey (1960) described O. pilosus from Mozambique. Evans (1987) revised the genus and described O. capriviensis and O. bicolor from Namibia. Finally, Lacroix (2005) described O. snizeki from Zimbabwe, O. squamosus from Botswana, and O. uhligi from Namibia.
February 5, 2018: Zootaxa
https://www.readbyqxmd.com/read/29689983/a-new-reed-frog-hyperoliidae-hyperolius-from-coastal-northeastern-mozambique
#18
Werner Conradie, Luke Verburgt, Daniel M Portik, Annemarie Ohler, Beryl A Bwong, Lucinda P Lawson
A new species of African reed frog (genus Hyperolius Rapp, 1842) is described from the Coastal Forests of the Eastern Africa Biodiversity Hotspot in northeastern Mozambique. It is currently only known from less than ten localities associated with the Mozambican coastal pans system, but may also occur in the southeastern corner of Tanzania. Phylogenetic reconstructions using the mitochondrial 16S marker revealed that it is the sister taxon of Hyperolius mitchelli (>5.6% 16S mtDNA sequence divergence) and forms part of a larger H...
February 13, 2018: Zootaxa
https://www.readbyqxmd.com/read/29674889/taxonomic-review-of-the-deep-water-flathead-genus-parabembras-with-description-of-the-new-species-parabembras-multisquamata-from-the-western-pacific-ocean-teleostei-parabembridae
#19
Yoshiaki Kai, Ronald Fricke
Three valid species of Parabembras are recognized: P. curta , P. robinsoni , and the new species P. multisquamata . Parabembras robinsoni from the southwestern Indian Ocean (South Africa to Mozambique) is easily distinguishable from the other species in having eleven spines in the first dorsal fin, a distinct symphyseal knob on the lower jaw, two preocular spines, and a single lachrymal spine. Parabembras multisquamata from the southwestern Pacific (Vanuatu, Papua New Guinea) and the Philippines, and P. curta , known from the northwestern Pacific (southern Japan to South China Sea), are similar in sharing the absence of a symphyseal knob on the lower jaw, the presence of two lachrymal spines, and a single preocular spine, but the former is clearly distinguished from the latter in usually having 10 spines in the first dorsal fin (vs...
2018: ZooKeys
https://www.readbyqxmd.com/read/29672219/seroepidemiology-of-chikungunya-virus-among-febrile-patients-in-eight-health-facilities-in-central-and-northern-mozambique-2015-2016
#20
Virgilio S António, Argentina F Muianga, Janett Wieseler, Sádia A Pereira, Vanessa O Monteiro, Flora Mula, Imelda Chelene, Inocêncio S Chongo, John O Oludele, Beate M Kümmerer, Eduardo S Gudo
BACKGROUND: The burden and spread of chikungunya virus (CHIKV) are rapidly increasing worldwide, but the epidemiology in Mozambique is barely known. The aim of this study was to determine the seroepidemiology of CHIKV in central and northern Mozambique. METHODS: A cross-sectional study was conducted between March 2015 and May 2016 in eight health facilities situated in central and northern Mozambique to recruit 392 patients with undifferentiated febrile illness from outpatient clinics...
April 19, 2018: Vector Borne and Zoonotic Diseases
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