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https://www.readbyqxmd.com/read/28530066/-position-statement-on-overactive-bladder
#1
Ilan Grunwald, Kobi Stav, Jacob Golomb, Joseph Abarbanel, Gabriel Gillon, Alexander Greenstein
Bothersome urinary symptoms during the storage phase are common among women and men. These symptoms described as urinary urgency, frequency and nocturia with or without urge urinary incontinence may be caused by various pathologies including bladder overactivity. Diagnosis of an overactive bladder is based on the patient's clinical presentation after exclusion of other disorders that may cause these symptoms. The minimal requirements for a urological evaluation include medical history, physical examination and urinalysis...
November 2016: Harefuah
https://www.readbyqxmd.com/read/28526220/lumbar-puncture-for-all-febrile-infants-29-56-days-old-a-retrospective-cohort-reassessment-study
#2
Richard Scarfone, Ashlee Murray, Payal Gala, Fran Balamuth
OBJECTIVES: To determine the incidence of bacterial meningitis (BM) among all febrile infants 29-56 days old undergoing a lumbar puncture (LP) in the emergency department of a tertiary care children's hospital and the number of low-risk febrile infants with BM to reassess the need for routine LP in these infants. STUDY DESIGN: Retrospective cohort study using a quality improvement registry from July 2007-April 2014. Infants included were 29-56 days old with fever and who had an LP in the emergency department...
May 16, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28522334/safety-evaluation-of-chlorella-sorokiniana-strain-ck-22-based-on-an-in-vitro-cytotoxicity-assay-and-a-13-week-subchronic-toxicity-trial-in-rats
#3
Sayaka Himuro, Sugi Ueno, Naoto Noguchi, Takuya Uchikawa, Toshihiro Kanno, Akira Yasutake
The genus Chlorella contains unicellular green algae that have been used as food supplements. The purpose of this work was to evaluate the safety of the Chlorella sorokiniana strain CK-22 using powdered preparation (CK-22P) both by in vitro and in vivo assays. These included an experiment for cytotoxicity using Chinese hamster lung fibroblasts (V79 cells) and a 13-week repeated-dose oral toxicity trial using Wistar rats. The cytotoxicity was evaluated by MTT assay of a hot water extract (Hw-Ex) and 80% ethanol extract (Et-Ex) of CK-22P, and no effect on cell viability was observed...
May 15, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28516158/a-management-algorithm-for-mitomycin-c-induced-cystitis
#4
Amy N Luckenbaugh, Rory M Marks, David C Miller, Alon Z Weizer, John T Stoffel, Jeffrey S Montgomery
Background/Objective: A post-bladder tumor resection dose of MMC can reduce non-invasive papillary (pTa) bladder cancer recurrences by up to 40%; this treatment is recommended in both the AUA and EUA non-muscle-invasive bladder cancer guidelines. A common complication of this treatment is eosinophilic cystitis. Symptoms range from mild urinary frequency and urgency to debilitating pain and dysuria. Currently, there is no established treatment algorithm for MMC-induced cystitis. Methods: Members of the Urologic Surgery Quality Collaborative (USQC), a group composed of over 160 private and academic urologists, met to discuss the management of patients with cystitis following MMC therapy...
April 27, 2017: Bladder Cancer
https://www.readbyqxmd.com/read/28513001/the-frequency-of-urinary-tract-infection-and-subclinical-bacteriuria-in-dogs-with-allergic-dermatitis-treated-with-oclacitinib-a-prospective-study
#5
Andrew C Simpson, Jennifer R Schissler, Rod A W Rosychuk, A Russell Moore
BACKGROUND: Oclacitinib is a selective Janus kinase inhibitor for the treatment of canine allergic pruritus and atopic dermatitis in dogs. Glucocorticoids and ciclosporin increase urinary tract infection (UTI) frequency in dogs with inflammatory skin disease. OBJECTIVE: Prospective study to evaluate the frequency of UTI and subclinical bacteriuria in dogs with allergic dermatitis receiving oclacitinib. METHODS: Client-owned dogs ≥2 years of age with a history of allergic dermatitis without apparent history of urinary tract disease or predisposition to UTI were included...
May 17, 2017: Veterinary Dermatology
https://www.readbyqxmd.com/read/28508976/idiopathic-collapsing-focal-segmental-glomerulosclerosis-in-an-81-year-old-japanese-woman-a-case-report-and-review-of-the-literature
#6
Jun Yamazaki, Eriko Kanehisa, Wakaba Yamaguchi, Jiro Kumagai, Kiyotaka Nagahama, Hajime Fujisawa
Focal segmental glomerulosclerosis (FSGS) is classified into five variants, with the collapsing variant being the most rare. Collapsing FSGS is characterized by a black racial predominance and is often associated with human immunodeficiency virus-associated nephropathy. However, the number of idiopathic cases is increasing and the presentation of non-black patients becoming more routine. Our analysis of 15 previous reports investigating FSGS variants shows that the collapsing variant accounts for 10.6 % of FSGS cases and its average age of onset is 32 years old...
November 2016: CEN Case Reports
https://www.readbyqxmd.com/read/28508677/ketonuria-may-be-associated-with-low-serum-amylase-independent-of-body-weight-and-glucose-metabolism
#7
Kei Nakajima, Eiji Oda
CONTEXT: Ketonuria, which reflects a preferential combustion of lipids relative to carbohydrates, is often observed in lean rather than obese people. Clinical studies have shown that individuals with diabetes and/or obesity predispose to have low serum amylase (LSA). OBJECTIVE: To investigate the association between ketonuria and LSA. METHODS: We examined ketonuria assessed by dipstick urinalysis and clinical parameters including serum amylase in 3638 Japanese people aged 25-79 years who underwent a health-screening checkup...
May 16, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28502496/minimal-food-effect-for-eicosapentaenoic-acid-and-docosahexaenoic-acid-bioavailability-from-omega-3-acid-ethyl-esters-with-an-advanced-lipid-technologies-tm-alt-%C3%A2-based-formulation
#8
Miguel A Lopez-Toledano, Thorsteinn Thorsteinsson, Ahmed A Daak, Kevin C Maki, Colleen Johns, Adrian L Rabinowicz, Frederick D Sancilio
BACKGROUND: The absorption of eicosapentaenoic acid (EPA; 20:5n-3) and docosahexaenoic acid (DHA; 22:6n-3) omega-3-acid ethyl esters (EEs) is influenced by food. There is a need for a formulation of EE that is less impacted by food effect. SC401 is a novel Advanced Lipid Technologies-based formulation of EPA-EE and DHA-EE. In the presence of an aqueous medium, Advanced Lipid Technologies forms stable micelles in situ independent of bile salt secretion. This effect is hypothesized to improve EPA-EE and DHA-EE bioavailability while it helps mitigate the food effect associated with their consumption...
March 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28492206/community-screening-for-pre-hypertension-traditional-risk-factors-and-markers-of-chronic-kidney-disease-in-ondo-state-south-western-nigeria
#9
Akinwumi A Akinbodewa, Ademola O Adejumo, Olusesan V Koledoye, Janet O Kolawole, Damilola Akinfaderin, Abiola O Lamidi, Gloria O Gbakinro, Christianah Ogunduyile, Walter B Osungbemiro
BACKGROUND: Chronic kidney disease (CKD) has become an epidemic with many recognised risk factors. However, the role of pre-hypertension in CKD is yet to be fully studied in our environment. OBJECTIVES: We set out to determine the magnitude of pre-hypertension and traditional CKD risk factors. We also determined their relationships to proteinuria. SUBJECTS AND METHODS: This was a descriptive, cross-sectional study conducted in two urban local government areas (Akure South and Ondo West) in Ondo State, Southwest Nigeria in March 2014...
January 2017: Nigerian Postgraduate Medical Journal
https://www.readbyqxmd.com/read/28492060/subcutaneous-implants-of-a-cholesterol-triglyceride-buprenorphine-suspension-in-rats
#10
M Guarnieri, C Brayton, R Sarabia-Estrada, B Tyler, P McKnight, L DeTolla
A Target Animal Safety protocol was used to examine adverse events in male and female Fischer F344/NTac rats treated with increasing doses of a subcutaneous implant of a lipid suspension of buprenorphine. A single injection of 0.65 mg/kg afforded clinically significant blood levels of drug for 3 days. Chemistry, hematology, coagulation, and urinalysis values with 2- to 10-fold excess doses of the drug-lipid suspension were within normal limits. Histopathology findings were unremarkable. The skin and underlying tissue surrounding the drug injection were unremarkable...
2017: Journal of veterinary medicine
https://www.readbyqxmd.com/read/28490898/education-and-screening-for-chronic-kidney-disease-in-indian-youth-pilot-program-results
#11
Panduranga S Rao, Julie A Wright Nunes, Brenda W Gillespie, Rachel L Perlman, Rajan Ravichandran
BACKGROUND: There is a paucity of information on kidney education and screening programs in Indian youth. METHODS: Participants (n=2,158) from Chennai colleges were educated about the kidneys and chronic kidney disease (CKD) and screened in a pilot program from April to May 2013. This entailed: 1) a presentation and educational video and 2) an on-site assessment of weight, blood pressure, and demographic information. Urinalysis (UA) kits were distributed and returned in ≤48 hours...
2017: International Journal of Nephrology and Renovascular Disease
https://www.readbyqxmd.com/read/28484584/etiology-and-laboratory-abnormalities-in-bacterial-meningitis-in-neonates-and-young-infants
#12
David Kotzbauer, Curtis Travers, Craig Shapiro, Margaux Charbonnet, Anthony Cooley, Deborah Andresen, Gary Frank
We conducted a retrospective review of electronic medical records of all cases of bacterial meningitis in neonates and young infants at our institution from 2004 to 2014. Fifty-six cases were identified. The most common causative organism was group B streptococcus, followed by Escherichia coli and then Listeria monocytogenes. Forty-four of the 56 patients in the study had abnormalities of the blood white blood cell (WBC) count. The most common WBC count abnormalities were leukopenia and elevation of the immature to total (I:T) neutrophil ratio...
April 6, 2017: Clinics and Practice
https://www.readbyqxmd.com/read/28479908/determinants-of-isolated-systolic-hypertension-among-diabetic-patients-visiting-the-diabetic-clinic-at-the-tamale-teaching-hospital-northern-ghana
#13
Richard Kd Ephraim, Abdul-Razak Saasi, Enoch O Anto, Prince Adoba
BACKGROUND: Hypertension and diabetes mellitus, two of the leading risk factors for atherosclerosis, are associated with numerous complications, including heart attacks and strokes. AIM: This study established the prevalence and determinants of isolated systolic hypertension (ISH) in diabetes mellitus patients visiting the Tamale Teaching Hospital. MATERIALS AND METHODS: In this purposive cross-sectional study, 107 diabetes mellitus patients were recruited from the out-patient diabetes clinic of the Tamale Teaching Hospital (TTH)...
December 2016: African Health Sciences
https://www.readbyqxmd.com/read/28479906/factors-associated-with-community-acquired-urinary-tract-infections-among-adults-attending-assessment-centre-mulago-hospital-uganda
#14
Deus Kabugo, Samuel Kizito, Dave Dhara Ashok, Kiwanuka Alexander Graham, Ronald Nabimba, Sandra Namunana, M Richard Kabaka, Beatrice Achan, Florence C Najjuka
BACKGROUND: Urinary tract infections (UTI) are a common medical problem affecting the general population and thus commonly encountered in medical practice, with the global burden of UTIs at about 150 million people. Because uropathogens largely originate from colonic flora, they are easy to predict, and this is the rationale for empirical treatment in Community Acquired-UTI (CA-UTIs). With the increasing prevalence of drug-resistant bacteria among adults with CA-UTI in Uganda, it is no longer adequate to manage CA-UTIs on empiric regimen without revising the susceptibility patterns of common CA-UTI causative agents...
December 2016: African Health Sciences
https://www.readbyqxmd.com/read/28479762/transurethral-resection-of-prostate-in-benign-prostatic-enlargement-with-underactive-bladder-a-retrospective-outcome-analysis
#15
Ashok Kumar Sokhal, Rahul Janak Sinha, Bimalesh Purkait, Vishwajeet Singh
PURPOSE: The purpose of this study was to evaluate the clinical outcome and efficacy of transurethral resection of the prostate in patients of benign prostatic enlargement (BPE) with underactive bladder. MATERIALS AND METHODS: Retrospective study of 174 patients, who underwent transurethral resection of prostate (TURP) between 2008 and 2015, for lower urinary tract symptoms with BPE with bladder underactivity. Clinical history, physical examination, renal function test, urinalysis, cystourethroscopy, transabdominal or transrectal ultrasonography, and urodynamic study were recorded...
April 2017: Urology Annals
https://www.readbyqxmd.com/read/28476493/promoting-appropriate-urine-culture-management-to-improve-health-care-outcomes-and-the-accuracy-of-catheter-associated-urinary-tract-infections
#16
REVIEW
Robert Garcia, Eric D Spitzer
Published literature indicates that the unjustified ordering or improper collection of urine for urinalysis or culture from either catheterized patients or those without indwelling devices, or misinterpretation of positive results, often leads to adverse health care events, including increased financial burdens, overreporting of mandated catheter-associated urinary tract infection events, overtreatment of patients with antimicrobial agents, selection of multidrug-resistant organisms, and Clostridium difficile infection...
May 2, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28464263/urised-3-and-ux-2000-automated-urine-sediment-analyzers-vs-manual-microscopic-method-a-comparative-performance-analysis
#17
Sathima Laiwejpithaya, Preechaya Wongkrajang, Kanit Reesukumal, Chonticha Bucha, Suriya Meepanya, Chanutchaya Pattanavin, Varanya Khejonnit, Achara Chuntarut
BACKGROUND: Fully automated urine analyzers now play an important role in routine urinalysis in most laboratories. The recently introduced UriSed 3 has a new automated digital imaging urine sediment analyzer with a phase contrast feature. The aim of this study was to compare the performance of the UriSed 3 and UX-2000 automated urine sediment analyzers with each other and with the results of the manual microscopic method. METHODS: Two hundred seventy-seven (277) samples of leftover fresh urine from our hospital's central laboratory were evaluated by two automated urine sediment analyzers-UriSed 3 and UX-2000...
May 2, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28460807/diagnostic-approach-to-constipation-impacts-pediatric-emergency-department-disposition
#18
Corrie E Chumpitazi, Chris A Rees, Elizabeth A Camp, Erin B Henkel, Karina L Valdez, Bruno P Chumpitazi
OBJECTIVES: Constipation is a common cause of abdominal pain in children presenting to the emergency department (ED). The objectives of this study were to determine the diagnostic evaluation undertaken for constipation and to assess the association of the evaluation with final ED disposition. METHODS: A retrospective chart review of children presenting to the pediatric ED of a quaternary care children's hospital with abdominal pain that received a soap suds enema therapy...
April 26, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28460742/revisiting-an-old-disease-risk-factors-for-bovine-enzootic-haematuria-in-the-kingdom-of-bhutan
#19
Arata Hidano, Basant Sharma, Karma Rinzin, Narapati Dahal, Kinzang Dukpa, Mark A Stevenson
Bovine enzootic haematuria (BEH) is a debilitating disease of cattle caused by chronic ingestion of bracken fern. Control of BEH is difficult when bracken fern is abundant and fodder resources are limited. To fill a significant knowledge gap on modifiable risk factors for BEH, we conducted a case-control study to identify cattle management practices associated with BEH in the Bhutanese cattle population. A case-control study involving 16 of the 20 districts of Bhutan was carried out between March 2012 and June 2014...
May 1, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28458688/long-term-safety-of-pegylated-coagulation-factor-viii-in-the-immune-deficient-rowett-nude-rat
#20
Caroline E Rasmussen, Jette Nowak, Julie M Larsen, Emma Moore, David Bell, Kai Chiu Liu, Nanna Skall Sorensen, Wendela A Kappers, Thomas Krogh-Meibom, Hanne Offenberg
Turoctocog alfa pegol (N8-GP) is a glycoPEGylated human recombinant factor VIII for the treatment of hemophilia A. The safety profile of rFVIII, and polyethylene glycols (PEG) technology, is well-established. Conducting long-term toxicity studies in animals using human proteins can be complicated by anti-drug antibody (ADA) development. To evaluate long-term safety of N8-GP, 26- and 52-week toxicity studies were conducted in immune-deficient rats dosed intravenously every fourth day with 0, 50, 150, 500, or 1200 IU/kg N8-GP...
2017: Journal of Toxicology
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