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https://www.readbyqxmd.com/read/29052031/do-pharmaceuticals-improve-driving-in-individuals-with-adhd-a-review-of-the-literature-and-evidence-for-clinical-practice
#1
REVIEW
Craig B H Surman, Ronna Fried, Lauren Rhodewalt, Heidi Boland
Attention-deficit/hyperactivity disorder (ADHD) is defined as a disorder of impaired attention and/or behavioral control. Studies suggest that the condition can dispose individuals to a higher risk of automobile accidents. ADHD symptoms respond to pharmacotherapy in a majority of uncomplicated cases. Evidence on how pharmacotherapies for ADHD impact driving behavior or outcomes could allow clinicians to support on-road safety rationally. We therefore undertook a review to identify the evidence base to date indicating positive or negative effects of pharmacotherapies on driving behavior in individuals with ADHD...
October 19, 2017: CNS Drugs
https://www.readbyqxmd.com/read/29051727/syvn1-an-erad-e3-ubiquitin-ligase-is-involved-in-gabaa%C3%AE-1-degradation-associated-with-methamphetamine-induced-conditioned-place-preference
#2
Dong-Liang Jiao, Yan Chen, Yao Liu, Yun-Yue Ju, Jian-Dong Long, Jiang Du, Chang-Xi Yu, Yu-Jun Wang, Min Zhao, Jing-Gen Liu
Abuse of methamphetamine (METH), a powerful addictive amphetamine-type stimulants (ATS), is becoming a global public health problem. The gamma-aminobutyric acid (GABA)ergic system plays a critical role in METH use disorders. By using rat METH conditioned place preference (CPP) model, we previously demonstrated that METH-associated rewarding memory formation was associated with the reduction of GABAAα1 expression in the dorsal straitum (Dstr), however, the underlying mechanism was unclear. In the present study, we found that METH-induced CPP formation was accompanied by a significant increase in the expression of Synovial apoptosis inhibitor 1 (SYVN1), an endoplasmic reticulum (ER)-associated degradation (ERAD) E3 ubiquitin ligase, in the Dstr...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29048188/effects-of-environmental-enrichment-on-d-amphetamine-self-administration-following-nicotine-exposure
#3
Dustin J Stairs, Sarah E Ewin, Megan M Kangiser, Markus N Pfaff
Adolescent nicotine exposure has been shown to lead to further psychostimulant use in adulthood. Previous preclinical research in rats has shown that environmental enrichment may protect against drug abuse vulnerability. The current study was designed to examine whether environmental enrichment can block the ability of adolescent nicotine exposure to increase d-amphetamine self-administration in adulthood. Male Sprague-Dawley rats were raised in either enriched conditions (ECs) or isolated conditions (ICs) and then injected with saline or nicotine (0...
October 2017: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29046483/deficiency-of-shank2-causes-mania-like-behavior-that-responds-to-mood-stabilizers
#4
Andrea L Pappas, Alexandra L Bey, Xiaoming Wang, Mark Rossi, Yong Ho Kim, Haidun Yan, Fiona Porkka, Lara J Duffney, Samantha M Phillips, Xinyu Cao, Jin-Dong Ding, Ramona M Rodriguiz, Henry H Yin, Richard J Weinberg, Ru-Rong Ji, William C Wetsel, Yong-Hui Jiang
Genetic defects in the synaptic scaffolding protein gene, SHANK2, are linked to a variety of neuropsychiatric disorders, including autism spectrum disorders, schizophrenia, intellectual disability, and bipolar disorder, but the molecular mechanisms underlying the pleotropic effects of SHANK2 mutations are poorly understood. We generated and characterized a line of Shank2 mutant mice by deleting exon 24 (Δe24). Shank2Δe24-/- mice engage in significantly increased locomotor activity, display abnormal reward-seeking behavior, are anhedonic, have perturbations in circadian rhythms, and show deficits in social and cognitive behaviors...
October 19, 2017: JCI Insight
https://www.readbyqxmd.com/read/29045307/prevalence-of-antipsychotic-treated-patients-in-a-cohort-of-adult-addicted-patients
#5
Hélène Peyrière, Caroline Diot, Erika Nogue, Marie Verschave, Morgan Laure, Marie-Christine Picot, Pierre Petit, Hélène Donnadieu-Rigole, Yves Leglise
PURPOSE: The objective of this cross-sectional study was to describe and estimate the prevalence of antipsychotics (AP) in a cohort of addicted patients, and to compare the profiles of addictive patients receiving AP or not. METHODS: We included all adult patients seen at the addiction care center of Montpellier University Hospital, between January 1, 2015, and March 31, 2015. Demographic, clinical, and therapeutic data were collected from the patients' medical records...
October 17, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29044958/a-simple-validated-multi-method-for-detecting-drugs-in-oral-fluid-by-ultra-performance-liquid-chromatography-tandem-mass-spectrometry-uplc-ms-ms
#6
Yufang Zheng, Erik Sparve, Mats Bergström
BACKGROUND: Oral fluid sampling offers several advantages compared to other methods of detecting drugs in biological matrices due to its easy sampling procedure and simple supervision. Hence, the use of oral fluid for drug testing is increasing in workplaces and in roadside testing. As a result, more laboratories are required to perform analyses of drugs in oral fluid. METHODS: A multi-method using Ultra Performance Liquid Chromatography-Tandem Mass Spectrometry (UPLC-MS/MS) for tracing drugs in oral fluid was developed...
October 16, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/29043836/amphetamine-derivatives-and-the-risk-of-pulmonary-arterial-hypertension-a-new-chapter-of-the-story
#7
Gérald Simonneau, Marc Humbert
No abstract text is available yet for this article.
October 18, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29040826/maintenance-on-naltrexone-amphetamine-decreases-cocaine-vs-food-choice-in-male-rhesus-monkeys
#8
Megan J Moerke, Matthew L Banks, Kejun Cheng, Kenner C Rice, S Stevens Negus
BACKGROUND: Cocaine use disorder remains a significant public health issue for which there are no FDA-approved pharmacotherapies. Amphetamine maintenance reduces cocaine use in preclinical and clinical studies, but the mechanism of this effect is unknown. Previous studies indicate a role for endogenous opioid release and subsequent opioid receptor activation in some amphetamine effects; therefore, the current study examined the role of mu-opioid receptor activation in d-amphetamine treatment effects in an assay of cocaine-vs-food choice...
October 13, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29037791/effect-of-optogenetic-modulation-on-entopeduncular-input-affects-thalamic-discharge-and-behavior-in-an-aav2-%C3%AE-synuclein-induced-hemiparkinson-rat-model
#9
Hyeong Cheol Moon, So Yoon Won, Eung Gook Kim, Hyong Kyu Kim, Chul Bum Cho, Young Seok Park
OBJECTIVE: Neuromodulation of the globus pallidus internus(GPi) alleviates Parkinson's disease symptoms. The primate GPi is homologous to the rat entopeduncular nucleus (EP). The aim of the present study was to determine if optogenetic modulation of the EP could alter parkinsonian behavior or thalamic discharge in a hemiparkinson rat model. METHODS: We injected an adeno-associated virus type-2 expressing α-synuclein (AAV2-α-syn) into the substantia nigra pars compacta (SNc) of the right hemisphere and confirmed parkinsonian behavior using an amphetamine-induced rotation test...
October 14, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29034650/a-complicated-case-of-resistant-hypertension
#10
Mauro Chiarito, Andrea Scotti, Carlo A Pivato, Giuseppe Cottone, Carlo Ballarotto, Cosmo Godino, Alberto Margonato
A 47-year-old woman presented with a history of resistant arterial hypertension, associated with disabling headache. She was subjected to an enormous number of tests in order to identify an underlying cause of secondary hypertension, such as pheochromocytoma or Cushing syndrome, but all the most common causes of secondary hypertension were investigated and gradually excluded. Factitious use of amphetamine or cocaine was excluded, and therapy compliance was verified by witnessed ingestion of drug therapy, in order to rule out Munchausen syndrome...
August 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/29032769/amphetamine-modestly-improves-conners-continuous-performance-test-performance-in-healthy-adults
#11
David A MacQueen, Arpi Minassian, Brook L Henry, Mark A Geyer, Jared W Young, William Perry
OBJECTIVES: Amphetamine improves vigilance as assessed by continuous performance tests (CPT) in children and adults with attention deficit hyperactivity disorder (ADHD). Less is known, however, regarding amphetamine effects on vigilance in healthy adults. Thus, it remains unclear whether amphetamine produces general enhancement of vigilance or if these effects are constrained to the remediation of deficits in patients with ADHD. METHODS: We tested 69 healthy adults (35 female) on a standardized CPT (Conner's CPT-2) after receiving 10- or 20-mg d-amphetamine or placebo...
October 16, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/29031851/constitutive-ret-signaling-leads-to-long-lasting-expression-of-amphetamine-induced-place-conditioning-via-elevation-of-mesolimbic-dopamine
#12
Jaakko Kopra, Marian Villarta-Aguilera, Mari Savolainen, Samo Weingerl, Timo T Myöhänen, Saara Rannanpää, Michael F Salvatore, Jaan-Olle Andressoo, T Petteri Piepponen
Addictive drugs enhance dopamine release in the striatum, which can lead to compulsive drug-seeking after repeated exposure. Glial cell line-derived neurotrophic factor (GDNF) is an important regulator of midbrain dopamine neurons, and may play a mechanistic role in addiction-related behaviors. To elucidate the components of GDNF-signaling that contribute to addiction-related behaviors of place preference and its extinction, we utilized two genetically modified GDNF mouse models in an amphetamine-induced conditioned place preference (CPP) paradigm and evaluated how the behavioral findings correlate with dopamine signaling in the dorsal and ventral striatum...
October 12, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29030166/mdpv-and-%C3%AE-pvp-use-in-humans-the-twisted-sisters
#13
REVIEW
Laurent Karila, Geneviève Lafaye, Amandine Scocard, Olivier Cottencin, Amine Benyamina
The new psychoactive substances phenomenon continues to represent a considerable public health challenge. Synthetic cathinones are β-keto amphetamine analogues, also known as legal highs, research chemicals, bath salts. These drugs have surfaced as a popular alternative to other illicit drugs of abuse, such as cocaine, MDMA, and methamphetamine, due to their potent psychostimulant and empathogenic effects. Pyrovalerone cathinones (a-pyrrolidinophenones) form a distinct group of designer cathinones, such as MDPV...
October 10, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29029537/the-synergistic-effect-of-dual-use-of-amphetamine-type-stimulants-and-ketamine-on-drug-induced-psychotic-symptoms-in-chinese-synthetic-drug-users
#14
Xue-Bing Liu, Yao Zhang, Xu-Yi Wang, Wei Hao
The use of amphetamine-type stimulants (ATS) and ketamine is of particular clinical concern because of its associated psychotic symptoms. In Chinese clinical practice, ATS and ketamine are commonly used simultaneously, but very few studies have reported the symptom profile of users who use both drugs. This study determined whether the combined use of ATS and ketamine is associated with more psychotic symptoms than either ATS or ketamine alone. According to drug use characteristics, 375 Chinese synthetic drug users were categorized into 2 pairs of comparison groups: ATS-only (n=125) vs...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29024685/cardiac-pathologic-findings-in-three-unusual-cases-of-sudden-cardiac-death-related-to-anorexiant-drugs
#15
Ornella Leone, Valentina Agostini, Alberto Foà, Bruna Cerbelli, Cira Rosaria Tiziana di Gioia, Mariarosaria Aromatario, Costantino Ciallella, Joaquin Lucena, Giulia d'Amati
Amphetamine congeners can be prescribed as anorexiant drugs, despite their potential side effects, including cardiac toxicity. However, the morphologic features of cardiac damage related to protracted use of these compounds are unknown. We provide a detailed description of cardiac autopsy findings in three cases of sudden death associated with protracted use of high-doses of phendimetrazine and/or phenylpropanolamine or bupropion prescribed as anorexiants, in association with other compounds. The main cardiac findings were similar in all three cases: i) mild-moderate hypertrophy of the left ventricle and/or the septum; ii) myocardial non-ischemic scarring (mid-mural and/or sub-epicardial) appearing as discrete foci or with a band/like morphology; iii) mild-moderate intramural small vessel disease, in absence of significant epicardial coronary artery stenosis; iv) acute/recent inflammatory lesions consistent with toxic myocarditis...
October 9, 2017: Human Pathology
https://www.readbyqxmd.com/read/29016884/cocaine-contamination-of-banknotes-a-review
#16
Gianmarco Troiano, Isabella Mercurio, Marco Golfera, Nicola Nante, Paola Melai, Massimo Lancia, Mauro Bacci
Background: The analysis of drug traces on banknotes with different validated techniques can provide important information about the types of substances that are used in a geographical region. The aim of our review was to investigate banknotes' contamination by cocaine, by its metabolite, but also by other drugs. Methods: A systematic literature search (English written literature) was conducted in MEDLINE, and Scopus, collecting studies from 1974 till 2017. The Key search terms included: 'banknote AND drug'; 'banknote AND cocaine'...
July 16, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/28993742/development-and-validation-of-the-amphetamine-type-stimulants-motive-questionnaire-in-a-clinical-population
#17
Daniela Thurn, Emmanuel Kuntsche, Jennifer Anna Weber, Jörg Wolstein
Approximately 35.7 million people world-wide use amphetamine-type stimulants (ATS) leading to a high demand for effective treatment. Understanding the motives behind ATS use is a necessary basis for preventive and therapeutic treatment. The objective of this study is to develop the Amphetamine-Type stimulants Motive Questionnaire (AMQ) and to confirm its construct and concurrent validity in respect to the first and the latest month of ATS use based on answers of 233 patients with ATS disorders (74.2% male; mean age: 31...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28993129/separating-the-agony-from-ecstasy-r-3-4-methylenedioxymethamphetamine-has-prosocial-and-therapeutic-like-effects-without-signs-of-neurotoxicity-in-mice
#18
Daniel W Curry, Matthew B Young, Andrew N Tran, Georges E Daoud, Leonard L Howell
S,R(+/-)-3,4-methylenedioxymethamphetamine (SR-MDMA) is an amphetamine derivative with prosocial and putative therapeutic effects. Ongoing clinical trials are investigating it as a treatment for post-traumatic stress disorder (PTSD) and other conditions. However, its potential for adverse effects such as hyperthermia and neurotoxicity may limit its clinical viability. We investigated the hypothesis that one of the two enantiomers of SR-MDMA, R-MDMA, would retain the prosocial and therapeutic effects but with fewer adverse effects...
October 6, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28992662/sample-preparation-method-for-the-combined-extraction-of-ethyl-glucuronide-and-drugs-of-abuse-in-hair
#19
Ulf Christian Juhl Meier, Thomas Briellmann, Eva Scheurer, Franz Dussy
In hair analysis often little hair sample is available while the analysis of a multitude of structurally diverse substances with different concentration ranges is demanded. Often, the analysis of the different substances requires different sample preparation methods, increasing the amount of required hair sample. When segmental hair analysis is necessary, the amount of needed hair sample is further increased. Therefore, the required sample amount for a full analysis can quickly exceed the available hair sample...
October 9, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28991519/association-between-binge-drug-use-and-suicide-attempt-among-people-who-inject-drugs
#20
Charles Fournier, Maykel Farag Ghabrash, Adelina Artenie, Elise Roy, Geng Zang, Julie Bruneau, Didier Jutras Aswad
BACKGROUND: People who inject drugs (PWID) have an elevated risk of suicide attempt. While different substances are associated with suicide attempt, the overall risk posed by binge behavior, a high risk pattern of drug use, remains unclear. Our objective is to assess the association between binge drug use and suicide attempt in a prospective cohort of PWID in Montreal, Canada. METHODS: Participants answered a biannual interviewer-administered questionnaire compiling information on sociodemographics, pattern of substance use (cocaine, amphetamine, opioids, sedative-hypnotics, alcohol and cannabis), psychosocial stressors and related markers...
October 9, 2017: Substance Abuse
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