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https://www.readbyqxmd.com/read/25847097/complex-alterations-in-microglial-m1-m2-markers-during-the-development-of-epilepsy-in-two-mouse-models
#1
Melissa J Benson, Silvia Manzanero, Karin Borges
OBJECTIVE: To characterize the changes in microglial proinflammatory M1 and antiinflammatory M2 marker expression during epileptogenesis in the chronic pilocarpine and intrahippocampal kainate models. METHODS: M1-activated microglia express proinflammatory cytokines driving infiltration of cells, whereas M2-activated microglia are more reparative, promoting phagocytosis of debris and expression of proteins associated with cellular stability and repair. Microglial markers were characterized as acute (3 days after status epilepticus [SE]), early chronic (21 days post-SE), and late chronic epileptic (5-12 months post-SE) time points...
June 2015: Epilepsia
https://www.readbyqxmd.com/read/23091569/the-psychoimmunology-of-lyme-tick-borne-diseases-and-its-association-with-neuropsychiatric-symptoms
#2
Robert C Bransfield
Disease progression of neuropsychiatric symptoms in Lyme/tick-borne diseases can be better understood by greater attention to psychoimmunology. Although there are multiple contributors that provoke and weaken the immune system, infections and persistent infections are significant causes of pathological immune reactions. Immune mediated ef-fects are a significant contributor to the pathophysiological processes and disease progression. These immune effects in-clude persistent inflammation with cytokine effects and molecular mimicry and both of these mechanisms may be present at the same time in persistent infections...
2012: Open Neurology Journal
https://www.readbyqxmd.com/read/20351463/tungiasis-infestation-in-tanzania
#3
Humphrey D Mazigo, Emmanuel Behamana, Maria Zinga, Jorg Heukelbach
Tungiasis is caused by the jigger flea Tunga penetrans. We describe a case of severe infestation from Kigoma region, Western Tanzania. A 19-year-old male with epilepsy and mental disability presented with ulcerated and inflamed toes. Clinical examination revealed the presence of approximately 810 embedded jigger fleas on the feet, and another 60 lesions on the hands. The patient presented with fissures on the feet, hands and soles. He had difficulty walking and erythematous, oedematous, ulcerated and inflamed skin around the feet...
March 2010: Journal of Infection in Developing Countries
https://www.readbyqxmd.com/read/19826510/breaching-the-barrier-and-inflaming-epilepsy-research
#4
COMMENT
Graeme J Sills, Tom Solomon
No abstract text is available yet for this article.
September 2009: Epilepsy Currents
https://www.readbyqxmd.com/read/19805733/hughlings-jackson-s-suggestion-for-the-treatment-of-epilepsy
#5
George K York, David A Steinberg
John Hughlings Jackson articulated a neurologic method of systematically evaluating the anatomy, physiology, and pathology of every patient with neurologic disease. He used this mode of analysis to develop a theory of the physiology of epilepsy. We examined an example of his method in a newly discovered, unpublished manuscript containing his suggestions for the treatment of epilepsy based on his physiologic ideas. He had his private papers destroyed at the time of his death, but the Rockefeller Library of the University College London Institute of Neurology, Queen Square, contains a collection of his papers probably saved from destruction by his collaborator James Taylor...
October 6, 2009: Neurology
https://www.readbyqxmd.com/read/17884753/hippocampal-sclerosis-in-association-with-neurocysticercosis
#6
Monika Singla, Parampreet Singh, Sandeep Kaushal, Rajinder Bansal, Gagandeep Singh
OBJECTIVE: To discuss the possible mechanisms underlying a dual pathology combining neurocysticercosis and hippocampal atrophy, illustrated by the observation of four patients with epilepsy. CASE REPORTS: The first patient presented at the age of four years with a first episode of status epilepticus, presumably due to an inflamed, calcified, parenchymal cysticercus granuloma. Thereafter, he had occasional seizures. Routine MRI undertaken several years later revealed unilateral hippocampal atrophy and sclerosis...
September 2007: Epileptic Disorders: International Epilepsy Journal with Videotape
https://www.readbyqxmd.com/read/16771129/does-vagus-nerve-constitute-a-self-organization-complexity-or-a-hidden-network
#7
REVIEW
B Mravec, I Hulin
The vagus nerve provides wide visceromotor and viscerosensory innervation of internal organs. Findings accumulated in last years suggest that vagus nerve participates on regulation of much wider spectrum of functions than described previously. Many different studies provide plausible evidence that vagus nerve importantly participates not only in transmission of information from inflamed tissues, but also in efferent modulation of inflammatory processes. Moreover, there are some findings supporting the hypothesis that vagus nerve might participates in monitoring and modulation of tumorigenesis...
2006: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/1495522/the-course-of-seizures-after-treatment-for-cerebral-cysticercosis
#8
V Vazquez, J Sotelo
BACKGROUND: Worldwide, cerebral cysticercosis is one of the most common causes of seizure disorders. Modern cysticidal drugs can usually eliminate the parasite from the brain, but there have been doubts as to whether such treatment improves the seizure disorder. METHODS: We studied 240 patients with seizures and cysticercosis of the brain parenchyma. Of these patients, 118 received cysticidal therapy (albendazole, praziquantel, or both) for lesions without inflammation on imaging studies (group 1); 49 patients with similar lesions either were not offered or refused cysticidal medication (group 2)...
September 3, 1992: New England Journal of Medicine
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