Qian Lu, Bo Pan, Haobo Bai, Weian Zhao, Lingjuan Liu, Gu Li, Ruimin Liu, Tiewei Lv, Xupei Huang, Xi Li, Jie Tian
In the past studies, it is shown that cardiac troponin I (cTnI, encoded by TNNI3 ), as a cytoplasmic protein, is an inhibitory subunit in troponin complex, and involves in cardiomyocyte diastolic regulation. Here, we assessed a novel role of cTnI as a nucleoprotein. Firstly, the nuclear translocation of cTnI was found in mouse, human fetuses and rat heart tissues. In addition, there were differences in percentage of intranuclear cTnI in different conditions. Based on weighted gene co-expression network analyses (WGCNA) and verification in cell experiments, a strong expression correlation was found between TNNI3 and Atp2a2 , which encodes sarco-endoplasmic reticulum Ca2+ ATPase isoform 2a (SERCA2a), and involves in ATP hydrolysis and Ca2+ transient...
November 2022: Genes & Diseases