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https://www.readbyqxmd.com/read/29720835/combination-of-garcinia-cambogia-extract-and-pear-pomace-extract-additively-suppresses-adipogenesis-and-enhances-lipolysis-in-3t3-l1-cells
#1
Kushal Sharma, Siwon Kang, Dalseong Gong, Sung-Hwa Oh, Eun-Young Park, Min-Ho Oak, Eunyoung Yi
Background: Inhibition of adipogenesis has been a therapeutic target for reducing obesity and obesity-related disorders such as diabetes, hypertension, atherosclerosis, and cancer. For decades, anti-adipogenic potential of many herbal extracts has been investigated. One example is Garcinia cambogia extract (GE) containing (-)-hydroxycitric acid as an active ingredient. GE is currently marketed as a weight loss supplement, used alone or with other ingredients. Pear pomace extract (PE), another natural product, has been also shown to have anti-adipogenic activity in a recent report...
April 2018: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29617865/adipose-tissue-specific-responses-reveal-an-important-role-of-lipogenesis-during-heat-stress-adaptation-in-pigs
#2
H Qu, K M Ajuwon
Elevated ambient temperature causes heat stress in pigs, resulting in reduced animal performance. To better understand tissue responses to heat stress in pigs, we conducted a study in which pigs were subjected to four treatments: acute (24 h) heat stress (AHS) at 35 °C ± 1 ambient temperature, chronic (7 d) heat stress at 35 °C ± 1 (HS) or normal ambient temperature (20 °C± 1) for 7 d with ad-libitum feeding (Con) or with pair-feeding to the feed intake (FI) of the HS pigs (PF). Heat stress decreased FI by approximately 36% and 64% in HS and AHS treatments respectively, compared with Con (P < 0...
April 3, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29617799/adipose-tissue-specific-responses-reveal-an-important-role-of-lipogenesis-during-heat-stress-adaptation-in-pigs1
#3
H Qu, K M Ajuwon
Elevated ambient temperature causes heat stress in pigs, resulting in reduced animal performance. To better understand tissue responses to heat stress in pigs, we conducted a study in which pigs were subjected to four treatments: acute (24 h) heat stress (AHS) at 35 °C ± 1 ambient temperature, chronic (7 d) heat stress at 35 °C ± 1 (HS) or normal ambient temperature (20 °C± 1) for 7 d with ad-libitum feeding (Con) or with pair-feeding to the feed intake (FI) of the HS pigs (PF). Heat stress decreased FI by approximately 36% and 64% in HS and AHS treatments respectively, compared with Con (P < 0...
April 2, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29579143/effort-testing-in-dementia-assessment-a-systematic-review
#4
Claire McGuire, Stephanie Crawford, Jonathan J Evans
Objective: Interpretation of neuropsychological test data is only valid when appropriate effort has been exerted. Research, however, suggests that neuropsychologists do not always formally test for effort and that this may especially be the case in the context of dementia assessment. This review systematically examined the literature that has investigated the use of both purpose-built and embedded effort-sensitive indices in dementia, mild cognitive impairment (MCI), and healthy control samples...
March 22, 2018: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/29111741/theoretical-probing-of-weak-anion-cation-interactions-in-certain-pyridinium-based-ionic-liquid-ion-pairs-and-the-application-of-molecular-electrostatic-potential-in-their-ionic-crystal-density-determination-a-comparative-study-using-density-functional-approach
#5
Aswathy Joseph, Vibin Ipe Thomas, Gaweł Żyła, A S Padmanabhan, Suresh Mathew
A comprehensive study on the structure, nature of interaction, and properties of six ionic pairs of 1-butylpyridinium and 1-butyl-4-methylpyridinium cations in combination with tetrafluoroborate (BF4 - ), chloride (Cl- ), and bromide (Br- ) anions have been carried out using density functional theory (DFT). The anion-cation interaction energy (ΔEint ), thermochemistry values, theoretical band gap, molecular orbital energy order, DFT-based chemical activity descriptors [chemical potential (μ), chemical hardness (η), and electrophilicity index (ω)], and distribution of density of states (DOS) of these ion pairs were investigated...
January 11, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29020498/lncrna-ccat1-mir-130a-3p-axis-increases-cisplatin-resistance-in-non-small-cell-lung-cancer-cell-line-by-targeting-sox4
#6
Baoli Hu, Haifeng Zhang, Zuopei Wang, Feng Zhang, Haitao Wei, Li Li
BACKGROUND: Colon cancer-associated transcript-1 (CCAT1) has been demonstrated to act as an oncogene and promote chemoresistance in several cancers. However, little is known about the underlying mechanism of CCAT1 in cisplatin (DDP) resistance of non-small-cell lung cancer (NSCLC) cells. METHODS: qRT-PCR was performed to detect the expression levels of CCAT, miR-130a-3p, or sex-determining region Y-box 4 (SOX4) mRNA. Luciferase reporter assay, RNA immunoprecipitation (RIP), and qRT-PCR analysis were carried out to explore the potential targets of CCAT1 or miR-130a-3p...
December 2, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/28978096/ccat-1-promotes-proliferation-and-inhibits-apoptosis-of-cervical-cancer-cells-via-the-wnt-signaling-pathway
#7
Jun Zhang, Yali Gao
Though the long noncoding RNA colon cancer associated transcript-1 (CCAT-1) has been shown to be involved in tumors of other tissues, its involvement in cervical cancer is still unknown. Therefore, the aim of this study was to investigate the molecular mechanism of CCAT-1 in cervical cancer. We quantified the expression of CCAT-1 long noncoding RNA in samples of cervical cancer tissue by real-time PCR. Effects of CCAT-1 expression on the proliferation and apoptosis of HeLa and CaSki cells were assessed by cell-count, colony-formation, and flow cytometry assays...
September 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28902370/nano-let%C3%A2-7b-sensitization-of-eliminating-esophageal-cancer-stem%C3%A2-like-cells-is-dependent-on-blockade-of-wnt-activation-of-symmetric-division
#8
Yamei Pang, Jian Liu, Xiang Li, Yiwen Zhang, Boxiang Zhang, Jing Zhang, Ning Du, Chongwen Xu, Rui Liang, Hong Ren, Shou-Ching Tang, Xin Sun
The poor therapy response and poor prognosis of esophageal cancer has made it one of the most malignant carcinoma, and the complicated multidisciplinary treatment failed to achieve a long-term disease-free survival. To diagnose esophageal cancer at an earlier stage, and to improve the effect of anticancer therapy would improve the therapeutic efficacy. After retrospective analysis of the cancer samples of patients who received esophagectomy, we found the relevance between ratio of either ALDH1 or CD133-positive cancer stem cells and 2-year recurrence...
October 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28754859/ccat-1-promotes-proliferation-and-inhibits-apoptosis-of-cervical-cancer-cells-via-the-wnt-signaling-pathway
#9
Jun Zhang, Yali Gao
Though the long noncoding RNA colon cancer associated transcript-1 (CCAT-1) has been shown to be involved in tumors of other tissues, its involvement in cervical cancer is still unknown. Therefore, the aim of this study was to investigate the molecular mechanism of CCAT-1 in cervical cancer. We quantified the expression of CCAT-1 long noncoding RNA in samples of cervical cancer tissue by real-time PCR. Effects of CCAT-1 expression on the proliferation and apoptosis of HeLa and CaSki cells were assessed by cell-count, colony-formation, and flow cytometry assays...
July 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28269974/exhaustive-exercise-decreases-l-type-calcium-current-by-activating-endoplasmic-reticulum-stress
#10
Yanzhuo Ma, Lingfeng Kong, Shuying Qi, Dongmei Wang
BACKGROUND: This study investigated effects of exhaustive exercise on L-type calcium current (ICa,L) and the putative intracellular cascade responsible for the effects. METHODS: Rats were randomly divided into three treatment groups: sedentary (without exercise), exercised to exhaustion and salubrinal injection before each exhaustive exercise period. Exercise group rats were forced to swim until exhaustion each time for 9 days with 5% body weight attached to the head...
April 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28067305/gomisin-n-inhibits-adipogenesis-and-prevents-high-fat-diet-induced-obesity
#11
Min-Kyung Jang, Ye-Rang Yun, Ji-Hyun Kim, Mi-Hee Park, Myeong Ho Jung
Gomisin N (GN) is a physiological lignan derived from Schisandra chinensis. In the present study, we investigated the inhibitory effects of GN on differentiation of 3T3-L1 preadipocytes and the anti-obesity effects of GN in high-fat diet (HFD)-induced obese mice. Incubation with GN significantly inhibited the differentiation of 3T3-L1 preadipocytes in a dose-dependent manner. This inhibitory effect primarily occurred at an early adipogenic stage through impairment of mitotic clonal expansion (MCE) caused by cell cycle arrest at the G1/S phase transition...
January 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/27987448/the-optimization-kinetics-and-mechanism-of-m-cresol-degradation-via-catalytic-wet-peroxide-oxidation-with-sludge-derived-carbon-catalyst
#12
Yamin Wang, Huangzhao Wei, Ying Zhao, Wenjing Sun, Chenglin Sun
The sludge-derived carbon catalyst modified with 0°C HNO3 solution was tested in catalytic wet peroxide oxidation of m-cresol (100mgL-1 ) with systematical mathematical models and theoretical calculation for the first time. The reaction conditions were optimized by response surface methodology (RSM) as T=60°C, initial pH=3.0, C0,H2O2(30%) =1.20gL-1 (lower than the stoichiometric amount of 1.80gL-1 ) and Ccat =0.80gL-1 , with 96% of m-cresol and 47% of TOC converted after 16min and 120min of reaction, respectively, and ξ (mg TOC/g H2 O2 fed)=83...
March 15, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/27374273/the-cancer-communication-assessment-tool-for-patients-and-families-ccat-pf-a-new-measure
#13
(no author information available yet)
No abstract text is available yet for this article.
2016: Psycho-oncology
https://www.readbyqxmd.com/read/27285686/heat-stress-in-pigs-is-accompanied-by-adipose-tissue-specific-responses-that-favor-increased-triglyceride-storage
#14
H Qu, H Yan, H Lu, S S Donkin, K M Ajuwon
Heat stress (HS) negatively affects all aspects of performance in pigs. Although certain tissue-specific responses in the liver, skeletal muscle, and intestine are known, there is paucity of information on responses within the adipose tissue. Therefore, the objective of this study was to delineate adipose tissue responses during HS in pigs. Thirty crossbred (Ossabaw × Duroc × Landrace) pigs were assigned to 3 treatments for 7 d. Treatments were 1) control and libitum fed (CON) with room temperature set at 20°C ± 1°C, 2) pair fed (PF) with room temperature as the CON treatment but pair fed to HS pigs, and 3) HS with room temperature 35°C ± 1°C and ad libitum access to feed...
May 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27222409/open-labelled-observations-of-language-dysfunction-in-old-ischemic-stroke-patients-with-aphasia-when-given-plant-and-marine-based-nutrient-supplements-for-12-weeks
#15
Guan-Yu Lin, Hsiu-Yu Chan, Chun-An Cheng, Lan-Ping Lin, Giia-Sheun Peng, Pei-Min Hsiao, Chun-Chieh Lin, Chun-Chih Lin, Jiunn-Tay Lee
BACKGROUND AND OBJECTIVES: This study aimed to explore the effect of functional foods on aphasia related to a previous ischemic stroke. When stroke-related neurological deficits result in physical dependency and poor selfcare that persists longer than 6 months, full recovery is almost impossible and the patient often requires long-term care. The functional foods, EASE123 and BioBalance#6, include numerous plant and marine-based nutrient supplements that could prove beneficial for such patients...
2016: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/26861832/exhaustive-exercise-decreases-l-type-calcium-current
#16
Yanzhuo Ma, Lingfeng Kong, Shuying Qi, Dongmei Wang
BACKGROUND: This study investigated effects of exhaustive exercise on L-type calcium current (ICa,L) and the putative intracellular cascade responsible for the effects. METHODS: Rats were randomly divided into three treatment groups: sedentary (without exercise), exercised to exhaustion and salubrinal injection before each exhaustive exercise period. Exercise group rats were forced to swim until exhaustion each time for 9 days with 5% body weight attached to the head...
February 10, 2016: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/26859319/a-systematic-review-of-psychosocial-interventions-for-children-and-young-people-with-epilepsy
#17
REVIEW
Fiona M Corrigan, Helen Broome, Liam Dorris
BACKGROUND: Despite recognition that psychosocial interventions can improve quality of life and mental health, there continues to be a lack of clarity and guidance around effective psychosocial interventions for children and young people with epilepsy. This review utilizes specific quality criteria to systematically identify and appraise the evidence for the effectiveness of psychosocial interventions for children and young people with epilepsy. METHODS: A systematic search of six electronic databases was conducted using predefined eligibility criteria...
March 2016: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/26686551/predictability-effect-on-n400-reflects-the-severity-of-reading-comprehension-deficits-in-aphasia
#18
Chih-Ting Chang, Chia-Ying Lee, Chia-Ju Chou, Jong-Ling Fuh, Hsin-Chi Wu
Predictability effect on N400, in which low predictability words elicited a larger N400 than high predictability words did over central to posterior electrodes, has been used to index difficulty of lexical retrieval and semantic integration of words in sentence comprehension. This study examined predictability effect on N400 in aphasic patients to determine if the properties of N400 are suited to indexing the severity of reading comprehension deficits. Patients with aphasia were divided into high and low ability groups based on scores on the reading comprehension subtest in the Chinese Concise Aphasia Test (CCAT)...
January 29, 2016: Neuropsychologia
https://www.readbyqxmd.com/read/26525538/assessment-of-an-electronic-learning-system-for-colon-capsule-endoscopy-a-pilot-study
#19
Hirotsugu Watabe, Tetsuya Nakamura, Atsuo Yamada, Yasuo Kakugawa, Sadaharu Nouda, Akira Terano
BACKGROUND: Training for colon capsule endoscopy (CCE) procedures is currently performed as a lecture and hands-on seminar. The aims of this pilot study were to assess the utility of an electronic learning system for CCE (ELCCE) designed for the Japanese Association for Capsule Endoscopy using an objective scoring engine, and to evaluate the efficacy of ELCCE on the acquisition of CCE reading competence. METHODS: ELCCE is an Internet-based learning system with the following steps: step 1, introduction; step 2, CCE reading competence assessment test (CCAT), which evaluates the competence of CCE reading prior to training; step 3, learning reading theory; step 4, training with guidance; step 5, training without guidance; step 6, final assessment; and step 7, the same as step 2...
June 2016: Journal of Gastroenterology
https://www.readbyqxmd.com/read/26371150/surgical-excision-of-a-giant-calcified-amorphous-tumour-of-the-right-ventricle-and-right-pulmonary-artery
#20
Edvin Prifti, Efrosina Kajo, Klodian Krakulli, Majlinda Ikonomi
A cardiac calcified amorphous tumour (CCAT) is a rare non-neoplastic intracavitary mass with unknown causes. We describe a 32-year old male presenting with progressive dyspnoea, cough and oedemas. The transthoracic echocardiography and contrast-enhanced angio-computed tomography demonstrated a 4 × 10 cm calcified mass into the right ventricle and total occlusion of the right pulmonary artery. The patient underwent successful total removal of the mass through a transverse right ventriculotomy, and right pulmonary embolectomy...
December 2015: Interactive Cardiovascular and Thoracic Surgery
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