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https://www.readbyqxmd.com/read/27926794/metastatic-type-a-thymoma-morphologic-and-genetic-correlation
#1
Tobias Bürger, Inga-Marie Schaefer, Stefan Küffer, Hanibal Bohnenberger, Kirsten Reuter-Jessen, John Kwok-Cheung Chan, Alexander Emmert, Marc Hinterthaner, Alexander Marx, Philipp Ströbel
INTRODUCTION: The vast majority of type A thymomas are diagnosed in tumor stage 1 or 2, and metastatic cases are exceedingly rare. The histological and genetic features of such metastatic type A thymomas have not been described in detail. METHODS: Five metastatic type A thymomas in tumor stage Masaoka IVb that had been reviewed by a panel of expert pathologists were analyzed using comparative genomic hybridization (CGH). All cases had metastasized to the lungs. RESULTS: Cases #1, 2 and 3 showed the prototypic morphology of type A thymomas with mostly solid growth patterns...
December 7, 2016: Histopathology
https://www.readbyqxmd.com/read/27925298/schwannoma-like-tumor-in-the-anterior-cranial-fossa-immunonegative-for-leu7-but-immunopositive-for-schwann-2e
#2
Christian Aïssè Bohoun, Yuzo Terakawa, Takeo Goto, Sayaka Tanaka, Yuko Kuwae, Masahiko Ohsawa, Hiroki Morisako, Kosuke Nakajo, Hidetoshi Sato, Kenji Ohata, Hideaki Yokoo
Schwannoma arising from the olfactory system, often called olfactory groove schwannoma (OGS), is rare, as the olfactory bulb and tract, belonging to the central nervous system, should lack Schwann cells. Another rare entity called olfactory ensheathing cell tumor (OECT) has been reported, which mimics clinical and radiological characteristics of OGS. Here, we report two rare cases of schwannoma-like tumor in the anterior cranial fossa that showed negative staining for Leu7, but positive staining for Schwann/2E, and discuss their origin...
December 7, 2016: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/27925167/size-matters-for-lice-on-birds-coevolutionary-allometry-of-host-and-parasite-body-size
#3
Andrea Harnos, Zsolt Lang, Dóra Petrás, Sarah E Bush, Krisztián Szabó, Lajos Rózsa
Body size is one of the most fundamental characteristics of all organisms. It influences physiology, morphology, behavior, and even interspecific interactions such as those between parasites and their hosts. Host body size influences the magnitude and variability of parasite size according to Harrison's Rule (HR: positive relationship between host and parasite body sizes) and Poulin's Increasing Variance Hypothesis (PIVH: positive relationship between host body size and the variability of parasite body size)...
December 7, 2016: Evolution; International Journal of Organic Evolution
https://www.readbyqxmd.com/read/27924579/reconstructing-erk-signaling-in-the-drosophila-embryo-from-fixed-images
#4
Bomyi Lim, Carmeline J Dsilva, Ioannis G Kevrekidis, Stanislav Y Shvartsman
The early Drosophila embryo provides unique opportunities for quantitative studies of ERK signaling. This system is characterized by simple anatomy, the ease of obtaining large numbers of staged embryos, and the availability of powerful tools for genetic manipulation of the ERK pathway. Here, we describe how these experimental advantages can be combined with recently developed microfluidic devices for high throughput imaging of ERK activation dynamics. We focus on the stage during the third hour of development, when ERK activation is essential for patterning of the future nerve cord...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27924529/alternaria-species-and-their-associated-mycotoxins
#5
Virginia Elena Fernández Pinto, Andrea Patriarca
The genus Alternaria includes more than 250 species. The traditional methods for identification of Alternaria species are based on morphological characteristics of the reproductive structures and sporulation patterns under controlled culture conditions. Cladistics analyses of "housekeeping genes" commonly used for other genera, failed to discriminate among the small-spored Alternaria species. The development of molecular methods achieving a better agreement with morphological differences is still needed. The production of secondary metabolites has also been used as a means of classification and identification...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27923976/early-restriction-of-placental-growth-results-in-placental-structural-and-gene-expression-changes-in-late-gestation-independent-of-fetal-hypoxemia
#6
Song Zhang, Paige Barker, Kimberley J Botting, Claire T Roberts, Christine M McMillan, Isabella Caroline McMillen, Janna L Morrison
Placental restriction and insufficiency are associated with altered patterns of placental growth, morphology, substrate transport capacity, growth factor expression, and glucocorticoid exposure. We have used a pregnant sheep model in which the intrauterine environment has been perturbed by uterine carunclectomy (Cx). This procedure results in early restriction of placental growth and either the development of chronic fetal hypoxemia (PaO2≤17 mmHg) in late gestation or in compensatory placental growth and the maintenance of fetal normoxemia (PaO2>17 mmHg)...
December 2016: Physiological Reports
https://www.readbyqxmd.com/read/27922106/in-situ-one-step-synthesis-of-carbon-encapsulated-naked-magnetic-metal-nanoparticles-conducted-without-additional-reductants-and-agents
#7
Jun Kang, Yeonwon Kim, Hye-Min Kim, Xiulan Hu, Nagahiro Saito, Jae-Hyuk Choi, Myeong-Hoon Lee
C-encapsulated highly pure Ni, Co, and Fe magnetic nanoparticles (MNPs/C) were synthesized by an innovative one-step in-situ plasma in liquid method (solution plasma processing, SPP) without any additional reductants, agents, or treatment. Successful encapsulation of MNPs was demonstrated by using inductively coupled plasma-atomic emission spectrometry and cyclic voltammetry techniques. The obtained X-ray diffraction patterns and transmission electron microscopy images corresponded to MNPs with average diameters of 5 nm and good crystalline structure...
December 6, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27921363/morphomechanics-and-developmental-constraints-in-the-evolution-of-ammonites-shell-form
#8
Alexander Erlich, Derek E Moulton, Alain Goriely, Regis Chirat
The idea that physical processes involved in biological development underlie morphogenetic rules and channel morphological evolution has been central to the rise of evolutionary developmental biology. Here, we explore this idea in the context of seashell morphogenesis. We show that a morphomechanical model predicts the effects of variations in shell shape on the ornamental pattern in ammonites, a now extinct group of cephalopods with external chambered shell. Our model shows that several seemingly unrelated characteristics of synchronous, ontogenetic, intraspecific, and evolutionary variations in ornamental patterns among various ammonite species may all be understood from the fact that the mechanical forces underlying the oscillatory behavior of the shell secreting system scale with the cross-sectional curvature of the shell aperture...
December 6, 2016: Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution
https://www.readbyqxmd.com/read/27920609/two-new-liolaemus-lizards-from-the-andean-highlands-of-southern-chile-squamata-iguania-liolaemidae
#9
Jaime Troncoso-Palacios, Hugo A Diaz, German I Puas, Edvin Riveros-Riffo, Alvaro A Elorza
Liolaemus is a diverse genus of lizards, subdivided into two subgenera: Liolaemus (sensu stricto) and Eulaemus, distributed mainly in Chile and Argentina. The Liolaemus elongatus-kriegi complex is the most diverse group within Liolaemus (sensu stricto), especially the species closely related to Liolaemus elongatus, which form a clade currently comprising nine species. Several Chilean species of this group have been recently described, mainly from volcanoes and poorly explored mountains. Here molecular and morphological evidence are provided for a new species of the Liolaemus elongatus clade, which is characterized by its small size and lack of dorsal pattern, unusual features for the species of this group of lizards...
2016: ZooKeys
https://www.readbyqxmd.com/read/27920606/phylogenetic-placement-of-the-pacific-northwest-subterranean-endemic-diving-beetle-stygoporus-oregonensis-larson-labonte-dytiscidae-hydroporinae
#10
Kojun Kanda, R Antonio Gomez, Richard Van Driesche, Kelly B Miller, David R Maddison
Stygoporus oregonensis Larson & LaBonte is a little-known subterranean diving beetle, which, until recently, had not been collected since the type series was taken from a shallow well in western Oregon, USA, in 1984. Here we report the discovery of additional specimens collected from a nearby well in the Willamette Valley. Sequence data from four mitochondrial genes, wingless, and histone III place Stygoporus Larson & LaBonte in the predominantly Mediterranean subtribe Siettitiina of the Hydroporini. Morphological support for these results is discussed, and details of the collecting circumstances of the new specimens are presented...
2016: ZooKeys
https://www.readbyqxmd.com/read/27920374/urban-driven-phenotypic-changes-empirical-observations-and-theoretical-implications-for-eco-evolutionary-feedback
#11
REVIEW
Marina Alberti, John Marzluff, Victoria M Hunt
Emerging evidence that cities drive micro-evolution raises the question of whether rapid urbanization of Earth might impact ecosystems by causing systemic changes in functional traits that regulate urban ecosystems' productivity and stability. Intraspecific trait variation-variation in organisms' morphological, physiological or behavioural characteristics stemming from genetic variability and phenotypic plasticity-has significant implications for ecological functions such as nutrient cycling and primary productivity...
January 19, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/27920231/bayesian-morphological-clock-methods-resurrect-placoderm-monophyly-and-reveal-rapid-early-evolution-in-jawed-vertebrates
#12
Benedict King, Tuo Qiao, Michael S Y Lee, Min Zhu, John A Long
The phylogeny of early gnathostomes provides an important framework for understanding one of the most significant evolutionary events, the origin and diversification of jawed vertebrates. A series of recent cladistic analyses have suggested that the placoderms, an extinct group of armoured fish, form a paraphyletic group basal to all other jawed vertebrates. We revised and expanded this morphological data set, most notably by sampling autapomorphies in a similar way to parsimony-informative traits, thus ensuring this data (unlike most existing morphological data sets) satisfied an important assumption of Bayesian tip-dated morphological clock approaches...
December 5, 2016: Systematic Biology
https://www.readbyqxmd.com/read/27919888/identification-of-a-novel-lincomycin-resistance-mutation-associated-with-activation-of-antibiotic-production-in-streptomyces-coelicolor-a3-2
#13
Guojun Wang, Masumi Izawa, Xiaoge Yang, Dongbo Xu, Yukinori Tanaka, Kozo Ochi
Comparative genome sequencing analysis of a lincomycin-resistant strain of Streptomyces coelicolor A3 (2) and the wild type strain identified a novel mutation conferring a high level of lincomycin resistance. Surprisingly, the new mutation was an in-frame DNA deletion in the genes SCO4597-SCO4598, resulting in formation of the hybrid gene linR SCO4597 and SCO4598 encode two histidine kinases, which, together with SCO4596, encoding a response regulator, constitute a unique two-component system. Sequence analysis indicated that these three genes and their arrangement patterns are ubiquitous among all Streptomyces genomes sequenced to date, suggesting these genes play important regulatory roles...
December 5, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27917480/evolutionary-processes-and-its-environmental-correlates-in-the-cranial-morphology-of-western-chipmunks-tamias
#14
Ana Paula A Assis, Daniela M Rossoni, James L Patton, Gabriel Marroig
The importance of the environment in shaping phenotypic evolution lies at the core of evolutionary biology. Chipmunks of the genus Tamias (subgenus Neotamias) are part of a very recent radiation, occupying a wide range of environments with marked niche partitioning among species. One open question is if and how those differences in environments affected phenotypic evolution in this lineage. Herein we examine the relative importance of genetic drift versus natural selection in the origin of cranial diversity exhibited by clade members...
December 5, 2016: Evolution; International Journal of Organic Evolution
https://www.readbyqxmd.com/read/27917187/integrating-physiology-and-architecture-in-models-of-fruit-expansion
#15
Mikolaj Cieslak, Ibrahim Cheddadi, Frédéric Boudon, Valentina Baldazzi, Michel Génard, Christophe Godin, Nadia Bertin
Architectural properties of a fruit, such as its shape, vascular patterns, and skin morphology, play a significant role in determining the distributions of water, carbohydrates, and nutrients inside the fruit. Understanding the impact of these properties on fruit quality is difficult because they develop over time and are highly dependent on both genetic and environmental controls. We present a 3D functional-structural fruit model that can be used to investigate effects of the principle architectural properties on fruit quality...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27916801/macromolecular-interactions-control-structural-and-thermal-properties-of-regenerated-tri-component-blended-films
#16
Ashley Lewis, Joshua C Waters, John Stanton, Joseph Hess, David Salas-de la Cruz
With a growing need for sustainable resources research has become highly interested in investigating the structure and physical properties of biomaterials composed of natural macromolecules. In this study, we assessed the structural, morphological, and thermal properties of blended, regenerated films comprised of cellulose, lignin, and hemicellulose (xylan) using the ionic liquid 1-allyl-3-methylimidazolium chloride (AMIMCl). Attenuated total reflectance Fourier transform infrared (ATR-FTIR) analysis, scanning electron microscopy (SEM), atomic force microscopy (AFM), X-ray scattering, and thermogravimetric analysis (TGA) were used to qualitatively and quantitatively measure bonding interactions, morphology, and thermal stability of the regenerated films...
November 28, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27916677/differential-copper-binding-to-alpha-synuclein-and-its-disease-associated-mutants-affect-the-aggregation-and-amyloid-formation
#17
Priyatosh Ranjan, Dhiman Ghosh, Deepthi S Yarramala, Subhadeep Das, Samir K Maji, Ashutosh Kumar
BACKGROUND: Copper is an essential trace element required for the proper functioning of various enzymes present in central nervous system. An imbalance in the copper homeostasis results in the pathology of various neurogenerative disorders including Parkinson's Disease. Hence, residue specific interaction of Cu(2+) to α-Syn along with the familial mutants H50Q and G51D needs to be studied in detail. METHODS: We investigated the residue specific mapping of Cu(2+) binding sites and binding strength using solution-state NMR and ITC respectively...
December 1, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27915342/in-vitro-effects-of-has-2-gene-silencing-on-the-proliferation-and-apoptosis-of-the-mcf-7-human-breast-cancer-cell-line
#18
Hong-Yan Zhang, Feng Liang, Fei Wang, Jian-Wei Zhang, Li Wang, Xi-Gang Kang, Jie Wang, Qi-Liu Duan
BACKGROUND: Breast cancer is characterized by a distinct metastatic pattern involving the regional lymph nodes, bone marrow, lung and liver. This study is aimed to investigate the effects of silencing the HAS-2 gene on the proliferation and apoptosis of human breast cancer cells. METHODS: MCF-7 cells were collected and assigned into control, scrambled siRNA and HAS-2- siRNA groups. After transfection, the morphological changes in the MCF-7 cells were observed using phase contrast microscopy...
December 5, 2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27914977/trematodes-with-a-reproductive-division-of-labor-heterophyids-also-have-a-soldier-caste-and-early-infections-reveal-how-colonies-become-structured
#19
Ana E Garcia-Vedrenne, Anastasia C E Quintana, Andrea M DeRogatis, Christina M Dover, Maribel Lopez, Armand M Kuris, Ryan F Hechinger
Recent findings have extended the documentation of complex sociality to the Platyhelminthes, describing the existence of a reproductive division of labor involving a soldier caste among the parthenitae of trematode parasites. However, all species examined to date occupy high positions in trematode interspecific dominance hierarchies and belong to two closely related families, the Echinostomatidae and the Philophthalmidae (Superfamily Echinostomatoidea). Further, the two species documented as lacking soldiers also belong to the Echinostomatidae...
November 30, 2016: International Journal for Parasitology
https://www.readbyqxmd.com/read/27914342/cu3-btc-2-catalyzed-dehydrogenative-coupling-of-dimethylphenylsilane-with-phenol-and-homocoupling-of-dimethylphenylsilane-to-disiloxane
#20
Nagaraj Anbu, Amarajothi Dhakshinamoorthy
Cu3(BTC)2 (BTC: 1,3,5-benzenetricarboxylic acid) showed to be an efficient and reusable heterogeneous solid catalyst for the formation of SiO bond through dehydrogenative coupling of dimethylphenylsilane (1) with phenol under mild reaction conditions. It is observed that Fe(BTC), MIL-101(Cr) and UiO-66(Zr) are not able to promote this cross coupling between 1 and phenol. Cu3(BTC)2 exhibits higher stability and activity compared to other MOFs studied here. Furthermore, Cu3(BTC)2 is reused for three consecutive cycles with a slight decay in its activity...
November 24, 2016: Journal of Colloid and Interface Science
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