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Gaën Plancher, Valérie Gyselinck, Pascale Piolino
Memory is one of the most important cognitive functions in a person's life as it is essential for recalling personal memories and performing many everyday tasks. Although a huge number of studies have been conducted in the field, only a few of them investigated memory in realistic situations, due to methodological issues. The various tools that have been developed using virtual environments (VEs) have gained popularity in cognitive psychology and neuropsychology because they enable to create naturalistic and controlled situations, and are thus particularly adapted to the study of episodic memory (EM), for which an ecological evaluation is of prime importance...
2018: Frontiers in Psychology
Christiane Cavalcante Feitoza, Matheus Corrêa da-Silva, Yasmim Lima Nascimento, Elaine Sobral Leite, Corintho Viana Pereira, Lucas Gomes Patrocínio
Obstructive Sleep Apnea Syndrome (OSA) is a multifactorial disease that highly alters a persons quality of life. It is characterized by the repeated interruption of breathing during sleep, due to an obstruction or the collapse of the upper airways. Since it is a multifactorial etiological disorder, it requires a thorough diagnosis and treatment with an interdisciplinary team, which comprises several professionals such as a surgical dentist, phonoaudiologist, otorhinolaryngologist, sleep doctor, neurologist and physiotherapist...
October 2017: Sleep Science
Sabrina Beer, Anders Garm, Bastian Huwer, Jan Dierking, Torkel Gissel Nielsen
Microplastic is considered a potential threat to marine life as it is ingested by a wide variety of species. Most studies on microplastic ingestion are short-term investigations and little is currently known about how this potential threat has developed over the last decades where global plastic production has increased exponentially. Here we present the first long-term study on microplastic in the marine environment, covering three decades from 1987 to 2015, based on a unique sample set originally collected and conserved for food web studies...
April 15, 2018: Science of the Total Environment
Dániel Sandi, Tamás Biernacki, Dóra Szekeres, Judit Füvesi, Zsigmond Tamás Kincses, Csilla Rózsa, Klotild Mátyás, Krisztián Kása, Judit Matolcsi, Dóra Zboznovits, Zita Burány, Éva Langane, László Vécsei, Krisztina Bencsik
BACKGROUND: Cognitive impairment (CI) is a frequent symptom of multiple sclerosis (MS); its prevalence is reported to be 43-70%. It is one of the most important determinants of MS patients' quality of life, as it is one of the main factors for MS patients becoming unemployed. AIM: We aimed to determine the prevalence of CI among the relapsing-remitting MS (RRMS) and clinically isolated syndrome (CIS) patients in Hungary, to evaluate the predicting factors of CI and to assess the differences between sexes and patients with different educational levels...
October 2017: Multiple Sclerosis and related Disorders
Vineet V Mishra, Sakshi Nanda, Bhumika Vyas, Rohina Aggarwal, Sumesh Choudhary, Suwa Ram Saini
BACKGROUND: Female sexual dysfunction (FSD) is described as difficulty experienced by a female during any stage of a normal sexual activity including physical pleasure, desire, arousal, or orgasm. There are various factors responsible for FSD including psychological status of a person, gynecological or medical problems, long use of certain drugs, and social beliefs. OBJECTIVES: To study the prevalence and various factors associated with FSD. MATERIALS AND METHODS: Study Design - This study design was a cross-sectional observational study conducted at Tertiary Care Centre, in Ahmedabad from June 2015 to March 2016...
October 2016: Journal of Mid-life Health
Jafar Razmara, Mohammad Hassan Zaboli
Falls play a critical role in older people's life as it is an important source of morbidity and mortality in elders. In this article, elders fall risk is predicted based on a physiological profile approach using a multilayer neural network with back-propagation learning algorithm. The personal physiological profile of 200 elders was collected through a questionnaire and used as the experimental data for learning and testing the neural network. The profile contains a series of simple factors putting elders at risk for falls such as vision abilities, muscle forces, and some other daily activities and grouped into two sets: psychological factors and public factors...
November 1, 2016: Health Informatics Journal
Jiao Wei, Danhua Ma, Min Qiu, Hongxia Dan, Xin Zeng, Lu Jiang, Yu Zhou, Jiayi Wang, Qianming Chen
Oral lichen planus (OLP) is a common chronic inflammatory disorder that manifests as papular, reticular, or erosive lesions. OLP seriously affects a patient's quality of life, as it is associated with symptoms such as pain and a burning sensation. It is also accompanied by a risk of carcinogenic tendency. During pregnancy, the treatment will be more complicated because of the effect of medical treatment on both the mother and foetus. Thus, appropriate drugs for those pregnant patients will be more essential...
January 2017: Acta Odontologica Scandinavica
M Molin, Y von Hausswolff-Juhlin, C Norring, L Hagberg, S A Gustafsson
BACKGROUND: Patients with severe and enduring eating disorders (SEED) are seriously ill and have a low quality of life. Case management (CM), originally developed for adult patients with severe mental disabilities, has been shown to enhance social functioning and improve quality of life, while reducing the number and length of hospitalizations. In 2014, a special unit based on CM, for patients with SEED (the Eira unit) was started at Stockholm Centre for Eating Disorders, Sweden. METHOD/DESIGN: This study aims to investigate if CM can improve SEED patients' quality of life, and reduce their eating disorder symptoms as well as their health care consumption...
2016: Journal of Eating Disorders
Miriam Zacchia, Maria Luisa Abategiovanni, Spiros Stratigis, Giovambattista Capasso
BACKGROUND: Potassium (K(+)) is the major intracellular cation, with 98% of the total pool being located in the cells at a concentration of 140-150 mmol/l, and only 2% in the extracellular fluid, where it ranges between 3.5 and 5 mmol/l. A fine regulation of the intracellular-extracellular gradient is crucial for life, as it is the main determinant of membrane voltage; in fact, acute changes of K(+) plasma levels may have fatal consequences. SUMMARY: An integrated system including an 'internal' and 'external' control prevents significant fluctuations of plasma levels in conditions of K(+) loading and depletion...
June 2016: Kidney Diseases
Shani Ofir-Eyal, Ilanit Hasson-Ohayon, Eran Bar-Kalifa, Shlomo Kravetz, Paul H Lysaker
OBJECTIVE: Studies have showed that therapists and mental health workers of persons with schizophrenia tend to estimate their patients' social quality of life (SQoL) as poorer than the clients' own estimation. This study explores the hypothesis that this discrepancy is related to clients' social cognition and symptomatology. DESIGN: Cross-sectional assessment of both clients and their mental health workers. METHODS: Ninety persons with schizophrenia and 12 persons who were formal care providers participated in the study...
June 2017: Psychology and Psychotherapy
Rob C van Lummel, Stefan Walgaard, Andrea B Maier, Erik Ainsworth, Peter J Beek, Jaap H van Dieën
BACKGROUND: The ability to rise from sitting to standing is critical to an individual's quality of life, as it is a prerequisite for functional independence. The purpose of the current study was to examine the hypothesis that test durations as assessed with the instrumented repeated Sit-To-Stand (STS) show stronger associations with health status, functional status and daily physical activity of older adults than manually recorded test durations. METHODS: In 63 older participants (mean age 83 ±6...
2016: PloS One
Sara Meninno, Alessandra Lattanzi
The asymmetric aldol reaction with formaldehyde is a fundamental carbon-carbon bond-forming reaction in organic synthesis, as well as in the quest of the origin of life, as it is thought to have been the first "molecular brick" involved in the synthetic path to complex sugars. Products of aldol reactions, i.e., the β-hydroxy carbonyl compounds, are versatile building blocks used to access a great variety of functionalised molecules. The employment of formaldehyde, as a C1 symmetric electrophile, in aldol reactions can be likely considered the most challenging, yet simplest, process to introduce a hydroxymethyl group in an asymmetric fashion...
August 2016: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
John B Bossaer, Stephen A Geraci, Kanishka Chakraborty
The advent of effective oral, molecular-targeted drugs in oncology has changed many incurable malignancies such as chronic myeloid leukemia into chronic diseases similar to coronary artery disease and diabetes mellitus. Oral agents including monoclonal antibodies, kinase inhibitors and hormone receptor blockers offer patients with cancer incremental improvements in both overall survival and quality of life. As it is imperative to recognize and manage side effects of platelet inhibitors, beta blockers, statins, human immunodeficiency virus drugs and fluoroquinolones by all healthcare providers, the same holds true for these newer targeted therapies; patients may present to their generalist or other subspecialist with drug-related symptoms...
May 2016: American Journal of the Medical Sciences
Palanisamy Athiyaman Balakumaran, Jan Förster, Martin Zimmermann, Jayachandran Charumathi, Andreas Schmitz, Eik Czarnotta, Mathias Lehnen, Suresh Sudarsan, Birgitta E Ebert, Lars Mathias Blank, Sankaranarayanan Meenakshisundaram
BACKGROUND: Copper is an essential chemical element for life as it is a part of prosthetic groups of enzymes including super oxide dismutase and cytochrome c oxidase; however, it is also toxic at high concentrations. Here, we present the trade-off of copper availability and growth inhibition of a common host used for copper-dependent protein production, Pichia pastoris. RESULTS: At copper concentrations ranging from 0.1 mM (6.35 mg/L) to 2 mM (127 mg/L), growth rates of 0...
2016: BMC Biotechnology
Celine H M Leenen, Mariska den Heijer, Conny van der Meer, Ernst J Kuipers, Monique E van Leerdam, Anja Wagner
Current genetic counselling practice for Lynch syndrome (LS) relies on diagnosed index patients to inform their biological family about LS, referred to as the family-mediated approach. The objective of this study was to evaluate this approach and to identify factors influencing the uptake of genetic testing for LS. In 59 mutation carriers, 70 non carriers and 16 non-tested relatives socio-demographic characteristics, family communication regarding LS, experiences and attitudes towards the family-mediated approach and motivations for genetic testing, were assessed...
January 2016: Familial Cancer
Sanvidhan G Suke, Prabhat Kosta, Harsh Negi
Pharmacovigilance (PV) plays a key role in the healthcare system through assessment, monitoring and discovery of interactions amongst drugs and their effects in human. Pharmaceutical and biotechnological medicines are designed to cure, prevent or treat diseases; however, there are also risks particularly adverse drug reactions (ADRs) can cause serious harm to patients. Thus, for safety medication ADRs monitoring required for each medicine throughout its life cycle, during development of drug such as pre-marketing including early stages of drug design, clinical trials, and post-marketing surveillance...
2015: Online Journal of Public Health Informatics
V N Manskikh, O S Gancharova, E A Novikov, E Iu Kondratiuk, V P Skulachev, M P Moshkin
The mole vole (Ellobius talpinus (Pallas), Rodentia) is the object of interest for cytogenetics, ecology and gerontology research, peculiarly because of partial similarity of this animal to the unique long-living rodent, mole rat. In this work, the mole vole has been found to have very specific spectrum of tumors and non-tumor pathologies which vastly differs from pathological lesions spectrum in mole rat, laboratory mouse, rat and hamster. Mole voles had relatively small tumor incidence (9% totally in the observed population and 16% in animals dead after the achievement of the first tumor development age) and long minimal span of tumor latency (549 days) that is why this species could be categorized as cancer-resistant in compare to laboratory rodents (mice, rats, hamsters)...
2015: Advances in Gerontology, Uspekhi Gerontologii
O E Mustafina, R Sh Somova
This review is devoted to the description of research achievements in genetics of aging and longevity. It represents a certain interest for understanding of a problems of aging as a whole. There is a huge amount of results of diverse genetic studies of aging and longevity. Studies were performed with using different experimental strategies on model organisms or samples from different human populations of the world. The search for aging and longevity genes was carried out within international consortiums. The first results of whole genome sequences of super-centenarians were received...
2015: Advances in Gerontology, Uspekhi Gerontologii
Bing Li, Weihua Xiong, Ou Wu, Weiming Hu, Stephen Maybank, Shuicheng Yan
Horror content sharing on the Web is a growing phenomenon that can interfere with our daily life and affect the mental health of those involved. As an important form of expression, horror images have their own characteristics that can evoke extreme emotions. In this paper, we present a novel context-aware multi-instance learning (CMIL) algorithm for horror image recognition. The CMIL algorithm identifies horror images and picks out the regions that cause the sensation of horror in these horror images. It obtains contextual cues among adjacent regions in an image using a random walk on a contextual graph...
December 2015: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
Jarosław Rydzek, Zbigniew T Gąsior, Józefa Dąbek, Jerzy Wojnar, Michał Skrzypek
BACKGROUND: Patients with advanced cancer after radio- and/or chemotherapy are increasingly commonly hospitalised in cardiology units due to coexisting cardiovascular diseases (CVD). A rational assessment of mortality risk is an important part of patient preparation for invasive cardiac procedures. One disadvantage of cardiac risk scores is the fact that malignancies are not taken into account. At present, accurate estimation of life expectancy is possible in up to 20% of patients with an advanced malignancy...
2015: Kardiologia Polska
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