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https://www.readbyqxmd.com/read/27826983/medical-treatments-for-pregnant-patients-with-oral-lichen-planus
#1
Jiao Wei, Danhua Ma, Min Qiu, Hongxia Dan, Xin Zeng, Lu Jiang, Yu Zhou, Jiayi Wang, Qianming Chen
Oral lichen planus (OLP) is a common chronic inflammatory disorder that manifests as papular, reticular, or erosive lesions. OLP seriously affects a patient's quality of life, as it is associated with symptoms such as pain and a burning sensation. It is also accompanied by a risk of carcinogenic tendency. During pregnancy, the treatment will be more complicated because of the effect of medical treatment on both the mother and foetus. Thus, appropriate drugs for those pregnant patients will be more essential...
November 9, 2016: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/27800159/case-management-at-an-outpatient-unit-for-severe-and-enduring-eating-disorder-patients-at-stockholm-centre-for-eating-disorders-a-study-protocol
#2
M Molin, Y von Hausswolff-Juhlin, C Norring, L Hagberg, S A Gustafsson
BACKGROUND: Patients with severe and enduring eating disorders (SEED) are seriously ill and have a low quality of life. Case management (CM), originally developed for adult patients with severe mental disabilities, has been shown to enhance social functioning and improve quality of life, while reducing the number and length of hospitalizations. In 2014, a special unit based on CM, for patients with SEED (the Eira unit) was started at Stockholm Centre for Eating Disorders, Sweden. METHOD/DESIGN: This study aims to investigate if CM can improve SEED patients' quality of life, and reduce their eating disorder symptoms as well as their health care consumption...
2016: Journal of Eating Disorders
https://www.readbyqxmd.com/read/27536695/potassium-from-physiology-to-clinical-implications
#3
REVIEW
Miriam Zacchia, Maria Luisa Abategiovanni, Spiros Stratigis, Giovambattista Capasso
BACKGROUND: Potassium (K(+)) is the major intracellular cation, with 98% of the total pool being located in the cells at a concentration of 140-150 mmol/l, and only 2% in the extracellular fluid, where it ranges between 3.5 and 5 mmol/l. A fine regulation of the intracellular-extracellular gradient is crucial for life, as it is the main determinant of membrane voltage; in fact, acute changes of K(+) plasma levels may have fatal consequences. SUMMARY: An integrated system including an 'internal' and 'external' control prevents significant fluctuations of plasma levels in conditions of K(+) loading and depletion...
June 2016: Kidney Diseases
https://www.readbyqxmd.com/read/27435825/agreement-between-clients-with-schizophrenia-and-mental-health-workers-on-clients-social-quality-of-life-the-role-of-social-cognition-and-symptoms
#4
Shani Ofir-Eyal, Ilanit Hasson-Ohayon, Eran Bar-Kalifa, Shlomo Kravetz, Paul H Lysaker
OBJECTIVE: Studies have showed that therapists and mental health workers of persons with schizophrenia tend to estimate their patients' social quality of life (SQoL) as poorer than the clients' own estimation. This study explores the hypothesis that this discrepancy is related to clients' social cognition and symptomatology. DESIGN: Cross-sectional assessment of both clients and their mental health workers. METHODS: Ninety persons with schizophrenia and 12 persons who were formal care providers participated in the study...
July 20, 2016: Psychology and Psychotherapy
https://www.readbyqxmd.com/read/27391082/the-instrumented-sit-to-stand-test-ists-has-greater-clinical-relevance-than-the-manually-recorded-sit-to-stand-test-in-older-adults
#5
Rob C van Lummel, Stefan Walgaard, Andrea B Maier, Erik Ainsworth, Peter J Beek, Jaap H van Dieën
BACKGROUND: The ability to rise from sitting to standing is critical to an individual's quality of life, as it is a prerequisite for functional independence. The purpose of the current study was to examine the hypothesis that test durations as assessed with the instrumented repeated Sit-To-Stand (STS) show stronger associations with health status, functional status and daily physical activity of older adults than manually recorded test durations. METHODS: In 63 older participants (mean age 83 ±6...
2016: PloS One
https://www.readbyqxmd.com/read/27328802/asymmetric-aldol-reaction-with-formaldehyde-a-challenging-process
#6
Sara Meninno, Alessandra Lattanzi
The asymmetric aldol reaction with formaldehyde is a fundamental carbon-carbon bond-forming reaction in organic synthesis, as well as in the quest of the origin of life, as it is thought to have been the first "molecular brick" involved in the synthetic path to complex sugars. Products of aldol reactions, i.e., the β-hydroxy carbonyl compounds, are versatile building blocks used to access a great variety of functionalised molecules. The employment of formaldehyde, as a C1 symmetric electrophile, in aldol reactions can be likely considered the most challenging, yet simplest, process to introduce a hydroxymethyl group in an asymmetric fashion...
August 2016: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/27140715/cardiovascular-toxicity-and-management-of-targeted-cancer-therapy
#7
REVIEW
John B Bossaer, Stephen A Geraci, Kanishka Chakraborty
The advent of effective oral, molecular-targeted drugs in oncology has changed many incurable malignancies such as chronic myeloid leukemia into chronic diseases similar to coronary artery disease and diabetes mellitus. Oral agents including monoclonal antibodies, kinase inhibitors and hormone receptor blockers offer patients with cancer incremental improvements in both overall survival and quality of life. As it is imperative to recognize and manage side effects of platelet inhibitors, beta blockers, statins, human immunodeficiency virus drugs and fluoroquinolones by all healthcare providers, the same holds true for these newer targeted therapies; patients may present to their generalist or other subspecialist with drug-related symptoms...
May 2016: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/26897180/the-trade-off-of-availability-and-growth-inhibition-through-copper-for-the-production-of-copper-dependent-enzymes-by-pichia-pastoris
#8
Palanisamy Athiyaman Balakumaran, Jan Förster, Martin Zimmermann, Jayachandran Charumathi, Andreas Schmitz, Eik Czarnotta, Mathias Lehnen, Suresh Sudarsan, Birgitta E Ebert, Lars Mathias Blank, Sankaranarayanan Meenakshisundaram
BACKGROUND: Copper is an essential chemical element for life as it is a part of prosthetic groups of enzymes including super oxide dismutase and cytochrome c oxidase; however, it is also toxic at high concentrations. Here, we present the trade-off of copper availability and growth inhibition of a common host used for copper-dependent protein production, Pichia pastoris. RESULTS: At copper concentrations ranging from 0.1 mM (6.35 mg/L) to 2 mM (127 mg/L), growth rates of 0...
2016: BMC Biotechnology
https://www.readbyqxmd.com/read/26446592/genetic-testing-for-lynch-syndrome-family-communication-and-motivation
#9
Celine H M Leenen, Mariska den Heijer, Conny van der Meer, Ernst J Kuipers, Monique E van Leerdam, Anja Wagner
Current genetic counselling practice for Lynch syndrome (LS) relies on diagnosed index patients to inform their biological family about LS, referred to as the family-mediated approach. The objective of this study was to evaluate this approach and to identify factors influencing the uptake of genetic testing for LS. In 59 mutation carriers, 70 non carriers and 16 non-tested relatives socio-demographic characteristics, family communication regarding LS, experiences and attitudes towards the family-mediated approach and motivations for genetic testing, were assessed...
January 2016: Familial Cancer
https://www.readbyqxmd.com/read/26392851/role-of-pharmacovigilance-in-india-an-overview
#10
Sanvidhan G Suke, Prabhat Kosta, Harsh Negi
Pharmacovigilance (PV) plays a key role in the healthcare system through assessment, monitoring and discovery of interactions amongst drugs and their effects in human. Pharmaceutical and biotechnological medicines are designed to cure, prevent or treat diseases; however, there are also risks particularly adverse drug reactions (ADRs) can cause serious harm to patients. Thus, for safety medication ADRs monitoring required for each medicine throughout its life cycle, during development of drug such as pre-marketing including early stages of drug design, clinical trials, and post-marketing surveillance...
2015: Online Journal of Public Health Informatics
https://www.readbyqxmd.com/read/26390611/-spectrum-of-spontaneous-pathological-changes-in-mole-voles-and-the-effect-of-mitochondria-targeted-antioxidant-skq1-on-it
#11
V N Manskikh, O S Gancharova, E A Novikov, E Iu Kondratiuk, V P Skulachev, M P Moshkin
The mole vole (Ellobius talpinus (Pallas), Rodentia) is the object of interest for cytogenetics, ecology and gerontology research, peculiarly because of partial similarity of this animal to the unique long-living rodent, mole rat. In this work, the mole vole has been found to have very specific spectrum of tumors and non-tumor pathologies which vastly differs from pathological lesions spectrum in mole rat, laboratory mouse, rat and hamster. Mole voles had relatively small tumor incidence (9% totally in the observed population and 16% in animals dead after the achievement of the first tumor development age) and long minimal span of tumor latency (549 days) that is why this species could be categorized as cancer-resistant in compare to laboratory rodents (mice, rats, hamsters)...
2015: Advances in Gerontology, Uspekhi Gerontologii
https://www.readbyqxmd.com/read/26390605/-some-results-of-molecular-genetic-researches-of-aging-and-longevity
#12
REVIEW
O E Mustafina, R Sh Somova
This review is devoted to the description of research achievements in genetics of aging and longevity. It represents a certain interest for understanding of a problems of aging as a whole. There is a huge amount of results of diverse genetic studies of aging and longevity. Studies were performed with using different experimental strategies on model organisms or samples from different human populations of the world. The search for aging and longevity genes was carried out within international consortiums. The first results of whole genome sequences of super-centenarians were received...
2015: Advances in Gerontology, Uspekhi Gerontologii
https://www.readbyqxmd.com/read/26390459/horror-image-recognition-based-on-context-aware-multi-instance-learning
#13
Bing Li, Weihua Xiong, Ou Wu, Weiming Hu, Stephen Maybank, Shuicheng Yan
Horror content sharing on the Web is a growing phenomenon that can interfere with our daily life and affect the mental health of those involved. As an important form of expression, horror images have their own characteristics that can evoke extreme emotions. In this paper, we present a novel context-aware multi-instance learning (CMIL) algorithm for horror image recognition. The CMIL algorithm identifies horror images and picks out the regions that cause the sensation of horror in these horror images. It obtains contextual cues among adjacent regions in an image using a random walk on a contextual graph...
December 2015: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/26390319/assessment-of-risk-factors-for-mortality-in-patients-with-cardiovascular-disease-and-a-history-of-treatment-for-malignancy
#14
Jarosław Rydzek, Zbigniew T Gąsior, Józefa Dąbek, Jerzy Wojnar, Michał Skrzypek
BACKGROUND: Patients with advanced cancer after radio- and/or chemotherapy are increasingly commonly hospitalised in cardiology units due to coexisting cardiovascular diseases (CVD). A rational assessment of mortality risk is an important part of patient preparation for invasive cardiac procedures. One disadvantage of cardiac risk scores is the fact that malignancies are not taken into account. At present, accurate estimation of life expectancy is possible in up to 20% of patients with an advanced malignancy...
2015: Kardiologia Polska
https://www.readbyqxmd.com/read/26389769/integrating-palliative-care-into-the-care-of-patients-with-advanced-lung-cancer
#15
REVIEW
Jennifer M Kapo, Kathleen M Akgün
Lung cancer is the leading cause of death due to malignancy. Although lung cancer mortality has been decreasing in recent years, it remains substantially higher than other causes of cancer death. Median survival for patients with locally advanced non-small cell lung cancer, defined as lung cancer involving regional lymph nodes, is estimated to be approximately 10 to 17 months, and median survival for patients with metastatic disease is only 6 to 9 months. In addition, patients with advanced lung cancer often experience debilitating symptoms and poor quality of life...
September 2015: Cancer Journal
https://www.readbyqxmd.com/read/26389150/reimbursement-for-end-of-life-planning-offers-dividends-to-emergency-providers
#16
(no author information available yet)
With the announcement by the Centers for Medicare and Medicaid Services (CMS) that it plans to begin paying providers to engage patients in end-of-life planning discussions, experts suggest emergency providers will need to up their game in terms of both discussing end-of-life care options with patients and families, as well interpreting choices that patients have spelled out in advance planning documents. A final decision on the proposal is not expected until November, but CMS has signaled that it is ready to implement the policy in January 2016...
September 2015: ED Management: the Monthly Update on Emergency Department Management
https://www.readbyqxmd.com/read/26389090/physicians-and-euthanasia-a-canadian-print-media-discourse-analysis-of-physician-perspectives
#17
David Kenneth Wright, Jennifer R Fishman, Hadi Karsoho, Sarah Sandham, Mary Ellen Macdonald
BACKGROUND: Recent events in Canada have mobilized public debate concerning the controversial issue of euthanasia. Physicians represent an essential stakeholder group with respect to the ethics and practice of euthanasia. Further, their opinions can hold sway with the public, and their public views about this issue may further reflect back upon the medical profession itself. METHODS: We conducted a discourse analysis of print media on physicians' perspectives about end-of-life care...
April 2015: CMAJ Open
https://www.readbyqxmd.com/read/26388864/applying-the-emergency-risk-management-process-to-tackle-the-crisis-of-antibiotic-resistance
#18
Dale Dominey-Howes, Beata Bajorek, Carolyn A Michael, Brittany Betteridge, Jonathan Iredell, Maurizio Labbate
We advocate that antibiotic resistance be reframed as a disaster risk management problem. Antibiotic-resistant infections represent a risk to life as significant as other commonly occurring natural disasters (e.g., earthquakes). Despite efforts by global health authorities, antibiotic resistance continues to escalate. Therefore, new approaches and expertise are needed to manage the issue. In this perspective we: (1) make a call for the emergency management community to recognize the antibiotic resistance risk and join in addressing this problem; (2) suggest using the risk management process to help tackle antibiotic resistance; (3) show why this approach has value and why it is different to existing approaches; and (4) identify public perception of antibiotic resistance as an important issue that warrants exploration...
2015: Frontiers in Microbiology
https://www.readbyqxmd.com/read/26388797/lessons-learnt-the-importance-of-metacognition-and-its-implications-for-cognitive-remediation-in-schizophrenia
#19
Matteo Cella, Clare Reeder, Til Wykes
The cognitive problems experienced by people with schizophrenia not only impede recovery but also interfere with treatments designed to improve overall functioning. Hence there has been a proliferation of new therapies to treat cognitive problems with the hope that improvements will benefit future intervention and recovery outcomes. Cognitive remediation therapy (CR) that relies on intensive task practice can support basic cognitive functioning but there is little evidence on how these therapies lead to transfer to real life skills...
2015: Frontiers in Psychology
https://www.readbyqxmd.com/read/26388765/the-importance-of-neighborhood-ecological-assets-in-community-dwelling-old-people-aging-outcomes-a-study-in-northern-portugal
#20
Alice M Bastos, Carla G Faria, Emília Moreira, Diana Morais, José M Melo-de-Carvalho, M Constança Paul
Human development is a bidirectional, person-context relational process, but scarce evidence is available about the relation between the individual variability across the life-span and the neighborhood ecological assets. Therefore, it is important that research focus not only on personal characteristics but on ecological assets as well. This way this study aims to analyze the association between neighborhood ecological assets categorized into four dimensions: human, physical or institutional, social or collective activity, accessibility, and the individual functioning...
2015: Frontiers in Aging Neuroscience
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