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https://www.readbyqxmd.com/read/27933751/synthesis-of-acetone-derived-c6-c9-and-c12-carbon-scaffolds-for-chemical-and-fuel-applications
#1
Cameron M Moore, Rhodri W Jenkins, Michael T Janicke, William L Kubic, Evgueni Polikarpov, Troy A Semelsberger, Andrew D Sutton
A simple, inexpensive catalyst system (Amberlyst 15 and Ni/SiO2 -Al2 O3 ) is described for the upgrading of acetone to a range of chemicals and potential fuels. Stepwise hydrodeoxygenation of the produced ketones can yield branched alcohols, alkenes, and alkanes. An analysis of these products is provided, which demonstrates that this approach can provide a product profile of valuable bioproducts and potential biofuels.
December 9, 2016: ChemSusChem
https://www.readbyqxmd.com/read/27932423/integrated-genomic-analysis-of-survival-outliers-in-glioblastoma
#2
Sen Peng, Harshil Dhurv, Brock Armstrong, Bodour Salhia, Christophe Legendre, Jeffrey Kiefer, Julianna Parks, Selene Virk, Andrew E Sloan, Quinn T Ostrom, Jill S Barnholtz-Sloan, Nhan L Tran, Michael E Berens
BACKGROUND: To elucidate molecular features associated with disproportionate survival of glioblastoma (GB) patients, we conducted deep genomic comparative analysis of a cohort of patients receiving standard therapy (surgery plus concurrent radiation and temozolomide); "GB outliers" were identified: long-term survivor of 33 months (LTS; n = 8) versus short-term survivor of 7 months (STS; n = 10). METHODS: We implemented exome, RNA, whole genome sequencing, and DNA methylation for collection of deep genomic data from STS and LTS GB patients...
December 8, 2016: Neuro-oncology
https://www.readbyqxmd.com/read/27930354/simultaneous-non-invasive-epicardial-and-endocardial-mapping-in-patients-with-brugada-syndrome-new-insights-into-arrhythmia-mechanisms
#3
Boris Rudic, Maria Chaykovskaya, Alexey Tsyganov, Vitaly Kalinin, Erol Tülümen, Theano Papavassiliu, Christina Dösch, Volker Liebe, Jürgen Kuschyk, Susanne Röger, Ibrahim El-Battrawy, Ibrahim Akin, Marina Yakovleva, Elena Zaklyazminskaya, Anna Shestak, Stanislav Kim, Mikhail Chmelevsky, Martin Borggrefe
BACKGROUND: The underlying mechanisms of Brugada syndrome (BrS) are not completely understood. Recent studies provided evidence that the electrophysiological substrate, leading to electrocardiogram abnormalities and/or ventricular arrhythmias, is located in the right ventricular outflow tract (RVOT). The purpose of this study was to examine abnormalities of epicardial and endocardial local unipolar electrograms by simultaneous noninvasive mapping in patients with BrS. METHODS AND RESULTS: Local epicardial and endocardial unipolar electrograms were analyzed using a novel noninvasive epi- and endocardial electrophysiology system (NEEES) in 12 patients with BrS and 6 with right bundle branch block for comparison...
November 14, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27929394/metabolism-of-ht-2-toxin-and-t-2-toxin-in-oats
#4
Jacqueline Meng-Reiterer, Christoph Bueschl, Justyna Rechthaler, Franz Berthiller, Marc Lemmens, Rainer Schuhmacher
The Fusarium mycotoxins HT-2 toxin (HT2) and T-2 toxin (T2) are frequent contaminants in oats. These toxins, but also their plant metabolites, may contribute to toxicological effects. This work describes the use of (13)C-assisted liquid chromatography-high-resolution mass spectrometry for the first comprehensive study on the biotransformation of HT2 and T2 in oats. Using this approach, 16 HT2 and 17 T2 metabolites were annotated including novel glycosylated and hydroxylated forms of the toxins, hydrolysis products, and conjugates with acetic acid, putative malic acid, malonic acid, and ferulic acid...
December 5, 2016: Toxins
https://www.readbyqxmd.com/read/27925318/total-synthesis-of-the-mycobacterium-tuberculosis-dideoxymycobactin-838-and-stereoisomers-diverse-cd1a-restricted-t-cells-display-a-common-hierarchy-of-lipopeptide-recognition
#5
Janice Cheng, Ligong Liu, Daniel Pellicci, Scott Jj Reddiex, Rachel Cotton, Tan-Yun Cheng, David Young, Ildiko Van Rhijn, Branch Moody, Jamie Rossjohn, David Fairlie, Dale Godfrey, Spencer John Williams
Mycobacterium tuberculosis produces dideoxymycobactin-838 (DDM-838), a lipopeptide that potently activates T cells upon binding to the MHC-like antigen-presenting molecule CD1a. M. tuberculosis produces DDM-838 in only trace amounts and a previous solid-phase synthesis provided sub-milligram quantities. We describe a high yielding solution-phase synthesis of DDM-838 that features a Mitsunobu substitution that avoids yield-limiting epimerization at lysine during esterification, and amidation conditions that prevent double-bond isomerization of the Z-C20:1 acyl chain, and provides material with equivalent antigenicity to natural DDM-838...
December 7, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27925200/production-of-macrophage-inhibitory-factor-mif-by-primary-sertoli-cells-its-possible-involvement-in-migration-of-spermatogonial-cells
#6
M Huleihel, M Abofoul-Azab, Y Abarbanel, I Einav, E Levitas, E Lunenfeld
Macrophage migration inhibitory factor (MIF) is a multifunctional molecule. MIF was originally identified as a T-cell-derived factor responsible for the inhibition of macrophage migration. In testicular tissue of adult rats, MIF is constitutively expressed by Leydig cells under physiological conditions. The aim of this study was to examine MIF levels in testicular homogenates from different aged mice, and the capacity of Sertoli cells to produce it. We also examined MIF involvement in spermatogonial cell migration...
December 7, 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27920296/a-sulfur-oxygenase-from-the-haloalkaliphilic-bacterium-thioalkalivibrio-paradoxus-with-atypically-low-reductase-activity
#7
Patrick Rühl, Uwe Pöll, Johannes Braun, Andreas Klingl, Arnulf Kletzin
: Sequence comparisons showed that the sulfur oxygenase reductase (SOR) of the haloalkaliphilic bacterium Thioalkalivibrio paradoxus Arh 1 (TpSOR) is branching deeply within dendrograms of these proteins (29-34% identity). A synthetic gene encoding the TpSOR expressed in E. coli resulted in a protein of 14.7±0.9 nm in diameter and an apparent molecular mass of 556 kDa. Sulfite and thiosulfate were formed from elemental sulfur in a temperature range of 10-98°C (Topt≈80°C) and a pH range of 6-11...
December 5, 2016: Journal of Bacteriology
https://www.readbyqxmd.com/read/27915068/effects-of-the-pulsed-ultrasound-therapy-on-sensory-nerve-conduction-parameters-and-the-pain-threshold-perceptions-in-humans
#8
Othmar Schuhfried, Damir Vukanovic, Christian Kollmann, Karin Pieber, Tatjana Paternostro-Sluga
BACKGROUND: Therapeutic ultrasound is a often used clinical modality in the non-surgical treatment of entrapment neuropathies. To date the possible mechanism of action of pulsed ultrasound therapy on the peripheral nerve in the treatment of entrapment neuropathies is unclear. OBJECTIVE: To examine the effects of pulsed ultrasound therapy on peripheral nerve conduction parameters. DESIGN: A prospective, randomized, single blind, cross-over study...
November 30, 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/27913399/development-of-time-and-voltage-domain-mapping-v-t-mapping-to-localize-ventricular-tachycardia-channels-during-sinus-rhythm
#9
Sachin Nayyar, Pawel Kuklik, Anand N Ganesan, Thomas R Sullivan, Lauren Wilson, Glenn D Young, Prashanthan Sanders, Kurt C Roberts-Thomson
BACKGROUND: In ventricular scar, impulse spread is slow because it traverses split and zigzag channels of surviving muscle. We aimed to evaluate scar electrograms to determine their local delay (activation time) and inequality in voltage splitting (entropy), and their relationship to channels. We reasoned that unlike innocuous channels, which are often short with multiple side branches, ventricular tachycardia (VT) supporting channels have very slow impulse spread and possess low entropy because of their longer protected length and relative lack of side-branching...
December 2016: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/27911430/-clinical-presentations-of-herpes-zoster-ophthalmicus-diagnosis-and-therapy
#10
G M Chernakova, E A Kleshcheva, T B Semenova
: Approximately a quarter of the world's population at some point in life is at risk of developing shingles (Herpes Zoster). In 10-20% of cases the first branch of the trigeminal nerve gets involved (Herpes Zoster Ophthalmicus, HZO). Ophthalmic complications of HZO are able to cause a significant reduction in visual function. AIM: To study and summarize clinical features of HZO (including the rate of complications and their nature) and to determine the relationship between clinical and laboratory data from these patients...
2016: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/27908677/haemodynamic-variations-of-flow-to-renal-arteries-in-custom-made-and-pivot-branch-fenestrated-endografting
#11
J Ou, A Y S Tang, T L Chiu, K W Chow, Y C Chan, S W K Cheng
OBJECTIVE: This study aimed to investigate variation of blood flow to renal arteries in custom-made and pivot branch (p-branch) fenestrated endografting, using a computational fluid dynamics (CFD) technique. METHODS: Idealised models of custom-made and p-branch fenestrated grafting were constructed on a basis of a 26 mm stent graft. The custom-made fenestration was designed with a 6 mm diameter, while the 5 mm depth renal p-branch was created with a 6 mm inner and 15 mm outer fenestration...
November 28, 2016: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/27906703/left-ventricular-ejection-fraction-and-mortality-in-patients-with-st-elevation-myocardial-infarction-and-bundle-branch-block
#12
M Yldau van der Ende, Minke H T Hartman, Tom Hendriks, Hindrik W van der Werf, Erik Lipsic, Pim van der Harst
BACKGROUND: The aim of our study is to assess the effect of bundle branch block (BBB) on mortality and left ventricular ejection fraction (LVEF) in ST-elevation myocardial infarction (STEMI) patients treated in the current era of percutaneous reperfusion therapy. PATIENTS AND METHODS: In this retrospective cohort study, a total of 1123 STEMI patients treated in the University Medical Center Groningen from January 2011 until May 2013 were included. The follow-up duration was 2-4 years...
November 30, 2016: Coronary Artery Disease
https://www.readbyqxmd.com/read/27905383/-the-role-of-atp-dependent-potassium-channels-and-nitric-oxide-system-in-the-neuroprotective-effect-of-preconditioning
#13
O G Deryagin, S A Gavrilova, S V Buravkov, V V Andrianov, G G Yafarova, Kh L Gainutdinov, V B Koshelev
AIM: To study a role of ATP-dependent potassium channels (K+ATP) in the neuroprotective effect of ischemic (IP) and pharmacological (PP) preconditioning and evaluate the dynamics of blood nitric oxide (NO) metabolites in cerebral ischemia. MATERIAL AND METHODS: A model of ischemic stroke induced by the electrocoagulation of a middle cerebral artery (MCA) branch was used in male rats (n=86). Glibenclamide, a selective inhibitor of ATP-sensitive K+ channels, and diazoxide, a potassium channel activator, were used...
2016: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/27903405/separation-of-44-ti-from-proton-irradiated-scandium-by-using-solid-phase-extraction-chromatography-and-design-of-44-ti-44-sc-generator-system
#14
V Radchenko, C A L Meyer, J W Engle, C M Naranjo, G A Unc, T Mastren, M Brugh, E R Birnbaum, K D John, F M Nortier, M E Fassbender
Scandium-44g (half-life 3.97h [1]) shows promise for positron emission tomography (PET) imaging of longer biological processes than that of the current gold standard, (18)F, due to its favorable decay parameters. One source of (44g)Sc is the long-lived parent nuclide (44)Ti (half-life 60.0 a). A (44)Ti/(44g)Sc generator would have the ability to provide radionuclidically pure (44g)Sc on a daily basis. The production of (44)Ti via the (45)Sc(p,2n) reaction requires high proton beam currents and long irradiation times...
November 24, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/27901499/genetic-characterization-of-esocid-herpesvirus-1-eshv1
#15
Jared T Freitas, Kuttichantran Subramaniam, Karen L Kelley, Susan Marcquenski, Joseph Groff, Thomas B Waltzek
Blue spot disease, believed to be caused by esocid herpesvirus 1 (EsHV1), has been observed in wild northern pike Esox lucius in a number of cold-water locations, including the northern USA, Canada, and Ireland. In the spring of 2014, a northern pike was caught in Wisconsin displaying the characteristic bluish-white circular plaques on the dorsum and fins. Microscopic examination of hematoxylin and eosin-stained sections of the proliferative cutaneous lesions revealed a focally extensive abundance of panepidermal, megalocytic keratinocytes with karyomegaly...
November 22, 2016: Diseases of Aquatic Organisms
https://www.readbyqxmd.com/read/27898943/effects-of-feeding-fermented-wheat-with-on-gut-morphology-intestinal-fermentation-nutrient-digestibility-and-growth-performance-in-weaned-pigs
#16
M H A Le, S Galle, Y Yang, J L Landero, E Beltranena, M G Gänzle, R T Zijlstra
Feeding fermented feed to weaned pigs may improve nutrient digestibility and gut health and thereby reduce diarrhea incidence. Effects of feeding wheat grain fermented for 24 h with were evaluated with 36 weaned pigs (7.3 kg BW). Fermented wheat grain contained (DM basis) 14.2% CP, 0.45% chemically available Lys, and 7.8% NDF, whereas unfermented wheat grain contained 16.4% CP, 0.45% chemically available Lys, and 9.9% NDF. Pigs were fed 6 mash wheat-based diets balanced for water content during 2 phases: Phase 1 diets for 1 wk (d 0-7) with 20% unfermented or fermented wheat and, subsequently, Phase 2 diets for 2 wk (d 8-21) with 50% unfermented or fermented wheat...
November 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27896699/cationized-carbohydrate-gas-phase-fragmentation-chemistry
#17
Benjamin J Bythell, Maha T Abutokaikah, Ashley R Wagoner, Shanshan Guan, Jordan M Rabus
We investigate the fragmentation chemistry of cationized carbohydrates using a combination of tandem mass spectrometry, regioselective labeling, and computational methods. Our model system is D-lactose. Barriers to the fundamental glyosidic bond cleavage reactions, neutral loss pathways, and structurally informative cross-ring cleavages are investigated. The most energetically favorable conformations of cationized D-lactose were found to be similar. In agreement with the literature, larger group I cations result in structures with increased cation coordination number which require greater collision energy to dissociate...
November 28, 2016: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/27892567/high-resolution-two-field-nuclear-magnetic-resonance-spectroscopy
#18
Samuel F Cousin, Cyril Charlier, Pavel Kadeřávek, Thorsten Marquardsen, Jean-Max Tyburn, Pierre-Alain Bovier, Simone Ulzega, Thomas Speck, Dirk Wilhelm, Frank Engelke, Werner Maas, Dimitrios Sakellariou, Geoffrey Bodenhausen, Philippe Pelupessy, Fabien Ferrage
Nuclear magnetic resonance (NMR) is a ubiquitous branch of spectroscopy that can explore matter at the scale of an atom. Significant improvements in sensitivity and resolution have been driven by a steady increase of static magnetic field strengths. However, some properties of nuclei may be more favourable at low magnetic fields. For example, transverse relaxation due to chemical shift anisotropy increases sharply at higher magnetic fields leading to line-broadening and inefficient coherence transfers. Here, we present a two-field NMR spectrometer that permits the application of rf-pulses and acquisition of NMR signals in two magnetic centres...
November 28, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27889934/vascular-cell-transcriptomic-changes-to-exercise-training-differ-directionally-along-and-between-skeletal-muscle-arteriolar-trees
#19
M Harold Laughlin, Hsiao T Yang, Darla L Tharp, R Scott Rector, Jaume Padilla, Douglas K Bowles
EXT-induced arteriolar adaptations in skeletal muscle are heterogeneous because of spatial variations in muscle fiber type composition and fiber recruitment patterns during exercise. The purpose of this report is to summarize a series of experiments conducted to test the hypothesis that changes in vascular gene expression are signaled by alterations in shear stress resulting from increases in blood flow, muscle fiber type composition and fiber recruitment patterns. We also report results from a follow-up study of Ankrd23, one gene whose expression was changed by EXT...
November 27, 2016: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/27886344/genetic-diversity-among-coffee-tree-progenies-big-coffee-vl-based-on-growth-traits-and-production
#20
J A Silva, S P Carvalho, A T Bruzi, R J Guimarães, L L Oliveira, L C Simões
In a coffee plantation of a coffee 'Acaiá' cultivar (Coffea arabica), on the Midwest of Minas Gerais in Capitólio city, a different kind of coffee tree was found (1989), possibly due to a mutation. It presented larger leaves and grains than those of conventional coffee trees and was named as "Big Coffee VL." The aim of this study was to estimate the genetic diversity of Big Coffee VL progenies cultivated at Universidade Federal de Lavras, by evaluating growth and production traits, based on genetic distances and clusters...
November 21, 2016: Genetics and Molecular Research: GMR
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