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https://www.readbyqxmd.com/read/28549996/the-effect-of-pr-interval-prolongation-on-long-term-outcomes-in-patients-with-left-bundle-branch-block-vs-non-left-bundle-branch-block-morphologies-undergoing-cardiac-resynchronization-therapy
#1
John Rickard, Mohammad Karim, Bryan Baranowski, Daniel Cantillon, David Spragg, Wh Wilson Tang, Mark Niebauer, Richard Grimm, Kevin Trulock, Bruce Wilkoff, Niraj Varma
BACKGROUND: While the influence of QRSd and/or bundle branch block morphology on outcomes to (CRT) have been well studied, the effect of PR interval remains uncertain. OBJECTIVE: We sought to evaluate the impact of PR prolongation(PRp) prior to cardiac resynchronization therapy (CRT) on long term outcomes, specifically taking into account bundle branch block morphology and QRS duration (QRSd). METHODS: We extracted clinical data on consecutive patients undergoing CRT...
May 23, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28549885/the-radial-approach-to-the-wrist-with-styloidectomy-a-cadaver-study
#2
F-A Lecoq, A Sébilo, P Bellemère
The radial approach to the wrist is already used in several surgical techniques such as radial styloidectomy and Zaidemberg's vascularized radial graft. The aim of our work was to describe the surgical anatomy of that approach and to determine the acceptable limits of radial oblique styloidectomy that does not damage the anterior and posterior radiocarpal ligaments. This radial approach was performed on 11 cadaver specimens. The superficial branches of the radial nerve and the antebrachial cephalic vein were carefully located in the superficial plane...
May 23, 2017: Hand Surgery and Rehabilitation
https://www.readbyqxmd.com/read/28549557/aberrant-distribution-of-the-trochlear-nerve-a-cadaveric-study-supported-by-immunohistochemistry
#3
Kojiro Takezawa, Grant Townsend, Jim Manavis, Mounir Ghabriel
The trochlear nerve is generally considered to be a purely motor nerve supplying one extraocular muscle, the superior oblique. In the current study, 28 orbits were dissected and in one orbit (3.6%), the trochlear nerve divided into two main branches. The medial branch followed the classical course, entered the superior oblique muscle and was presumed to be motor in function. However, before entering the muscle, it partially fused with the frontal nerve, and gave a bundle of nerve fibres to the frontal nerve...
May 23, 2017: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/28549182/single-provenance-mature-conifers-show-higher-non-structural-carbohydrate-storage-and-reduced-growth-in-a-drier-location
#4
Frida I Piper, Alex Fajardo, Günter Hoch
Since growth is more sensitive to drought than photosynthesis, trees inhabiting dry regions are expected to exhibit higher carbohydrate storage and less growth than their conspecifics from more humid regions. However, the same pattern can be the result of different genotypes inhabiting contrasting humidity conditions. To test if reduced growth and high carbohydrate storage are environmentally driven by drought, we examined the growth and non-structural carbohydrate (NSC) concentrations in single-provenance stands of mature trees of Pinus contorta Douglas and Pinus ponderosa Douglas ex C...
May 26, 2017: Tree Physiology
https://www.readbyqxmd.com/read/28548525/measurement-of-the-b_-s-0-%C3%A2-%C3%AE-%C3%AE-branching-fraction-and-effective-lifetime-and-search-for-b-0-%C3%A2-%C3%AE-%C3%AE-decays
#5
R Aaij, B Adeva, M Adinolfi, Z Ajaltouni, S Akar, J Albrecht, F Alessio, M Alexander, S Ali, G Alkhazov, P Alvarez Cartelle, A A Alves, S Amato, S Amerio, Y Amhis, L An, L Anderlini, G Andreassi, M Andreotti, J E Andrews, R B Appleby, F Archilli, P d'Argent, J Arnau Romeu, A Artamonov, M Artuso, E Aslanides, G Auriemma, M Baalouch, I Babuschkin, S Bachmann, J J Back, A Badalov, C Baesso, S Baker, V Balagura, W Baldini, A Baranov, R J Barlow, C Barschel, S Barsuk, W Barter, F Baryshnikov, M Baszczyk, V Batozskaya, B Batsukh, V Battista, A Bay, L Beaucourt, J Beddow, F Bedeschi, I Bediaga, A Beiter, L J Bel, V Bellee, N Belloli, K Belous, I Belyaev, E Ben-Haim, G Bencivenni, S Benson, S Beranek, A Berezhnoy, R Bernet, A Bertolin, C Betancourt, F Betti, M-O Bettler, M van Beuzekom, Ia Bezshyiko, S Bifani, P Billoir, A Birnkraut, A Bitadze, A Bizzeti, T Blake, F Blanc, J Blouw, S Blusk, V Bocci, T Boettcher, A Bondar, N Bondar, W Bonivento, I Bordyuzhin, A Borgheresi, S Borghi, M Borisyak, M Borsato, F Bossu, M Boubdir, T J V Bowcock, E Bowen, C Bozzi, S Braun, T Britton, J Brodzicka, E Buchanan, C Burr, A Bursche, J Buytaert, S Cadeddu, R Calabrese, M Calvi, M Calvo Gomez, A Camboni, P Campana, D H Campora Perez, L Capriotti, A Carbone, G Carboni, R Cardinale, A Cardini, P Carniti, L Carson, K Carvalho Akiba, G Casse, L Cassina, L Castillo Garcia, M Cattaneo, G Cavallero, R Cenci, D Chamont, M Charles, Ph Charpentier, G Chatzikonstantinidis, M Chefdeville, S Chen, S F Cheung, V Chobanova, M Chrzaszcz, A Chubykin, X Cid Vidal, G Ciezarek, P E L Clarke, M Clemencic, H V Cliff, J Closier, V Coco, J Cogan, E Cogneras, V Cogoni, L Cojocariu, P Collins, A Comerma-Montells, A Contu, A Cook, G Coombs, S Coquereau, G Corti, M Corvo, C M Costa Sobral, B Couturier, G A Cowan, D C Craik, A Crocombe, M Cruz Torres, S Cunliffe, R Currie, C D'Ambrosio, F Da Cunha Marinho, E Dall'Occo, J Dalseno, P N Y David, A Davis, K De Bruyn, S De Capua, M De Cian, J M De Miranda, L De Paula, M De Serio, P De Simone, C T Dean, D Decamp, M Deckenhoff, L Del Buono, M Demmer, A Dendek, D Derkach, O Deschamps, F Dettori, B Dey, A Di Canto, H Dijkstra, F Dordei, M Dorigo, A Dosil Suárez, A Dovbnya, K Dreimanis, L Dufour, G Dujany, K Dungs, P Durante, R Dzhelyadin, A Dziurda, A Dzyuba, N Déléage, S Easo, M Ebert, U Egede, V Egorychev, S Eidelman, S Eisenhardt, U Eitschberger, R Ekelhof, L Eklund, S Ely, S Esen, H M Evans, T Evans, A Falabella, N Farley, S Farry, R Fay, D Fazzini, D Ferguson, G Fernandez, A Fernandez Prieto, F Ferrari, F Ferreira Rodrigues, M Ferro-Luzzi, S Filippov, R A Fini, M Fiore, M Fiorini, M Firlej, C Fitzpatrick, T Fiutowski, F Fleuret, K Fohl, M Fontana, F Fontanelli, D C Forshaw, R Forty, V Franco Lima, M Frank, C Frei, J Fu, W Funk, E Furfaro, C Färber, A Gallas Torreira, D Galli, S Gallorini, S Gambetta, M Gandelman, P Gandini, Y Gao, L M Garcia Martin, J García Pardiñas, J Garra Tico, L Garrido, P J Garsed, D Gascon, C Gaspar, L Gavardi, G Gazzoni, D Gerick, E Gersabeck, M Gersabeck, T Gershon, Ph Ghez, S Gianì, V Gibson, O G Girard, L Giubega, K Gizdov, V V Gligorov, D Golubkov, A Golutvin, A Gomes, I V Gorelov, C Gotti, E Govorkova, R Graciani Diaz, L A Granado Cardoso, E Graugés, E Graverini, G Graziani, A Grecu, R Greim, P Griffith, L Grillo, B R Gruberg Cazon, O Grünberg, E Gushchin, Yu Guz, T Gys, C Göbel, T Hadavizadeh, C Hadjivasiliou, G Haefeli, C Haen, S C Haines, B Hamilton, X Han, S Hansmann-Menzemer, N Harnew, S T Harnew, J Harrison, M Hatch, J He, T Head, A Heister, K Hennessy, P Henrard, L Henry, E van Herwijnen, M Heß, A Hicheur, D Hill, C Hombach, P H Hopchev, Z-C Huard, W Hulsbergen, T Humair, M Hushchyn, D Hutchcroft, M Idzik, P Ilten, R Jacobsson, J Jalocha, E Jans, A Jawahery, F Jiang, M John, D Johnson, C R Jones, C Joram, B Jost, N Jurik, S Kandybei, M Karacson, J M Kariuki, S Karodia, M Kecke, M Kelsey, M Kenzie, T Ketel, E Khairullin, B Khanji, C Khurewathanakul, T Kirn, S Klaver, K Klimaszewski, T Klimkovich, S Koliiev, M Kolpin, I Komarov, P Koppenburg, A Kosmyntseva, S Kotriakhova, M Kozeiha, L Kravchuk, K Kreplin, M Kreps, P Krokovny, F Kruse, W Krzemien, W Kucewicz, M Kucharczyk, V Kudryavtsev, A K Kuonen, K Kurek, T Kvaratskheliya, D Lacarrere, G Lafferty, A Lai, G Lanfranchi, C Langenbruch, T Latham, C Lazzeroni, R Le Gac, J van Leerdam, A Leflat, J Lefrançois, R Lefèvre, F Lemaitre, E Lemos Cid, O Leroy, T Lesiak, B Leverington, T Li, Y Li, Z Li, T Likhomanenko, R Lindner, F Lionetto, X Liu, D Loh, I Longstaff, J H Lopes, D Lucchesi, M Lucio Martinez, H Luo, A Lupato, E Luppi, O Lupton, A Lusiani, X Lyu, F Machefert, F Maciuc, O Maev, K Maguire, S Malde, A Malinin, T Maltsev, G Manca, G Mancinelli, P Manning, J Maratas, J F Marchand, U Marconi, C Marin Benito, M Marinangeli, P Marino, J Marks, G Martellotti, M Martin, M Martinelli, D Martinez Santos, F Martinez Vidal, D Martins Tostes, L M Massacrier, A Massafferri, R Matev, A Mathad, Z Mathe, C Matteuzzi, A Mauri, E Maurice, B Maurin, A Mazurov, M McCann, A McNab, R McNulty, B Meadows, F Meier, D Melnychuk, M Merk, A Merli, E Michielin, D A Milanes, M-N Minard, D S Mitzel, A Mogini, J Molina Rodriguez, I A Monroy, S Monteil, M Morandin, P Morawski, M J Morello, O Morgunova, J Moron, A B Morris, R Mountain, F Muheim, M Mulder, M Mussini, D Müller, J Müller, K Müller, V Müller, P Naik, T Nakada, R Nandakumar, A Nandi, I Nasteva, M Needham, N Neri, S Neubert, N Neufeld, M Neuner, T D Nguyen, C Nguyen-Mau, S Nieswand, R Niet, N Nikitin, T Nikodem, A Nogay, A Novoselov, D P O'Hanlon, A Oblakowska-Mucha, V Obraztsov, S Ogilvy, R Oldeman, C J G Onderwater, J M Otalora Goicochea, A Otto, P Owen, A Oyanguren, P R Pais, A Palano, M Palutan, A Papanestis, M Pappagallo, L L Pappalardo, C Pappenheimer, W Parker, C Parkes, G Passaleva, A Pastore, M Patel, C Patrignani, A Pearce, A Pellegrino, G Penso, M Pepe Altarelli, S Perazzini, P Perret, M Perrin-Terrin, L Pescatore, K Petridis, A Petrolini, A Petrov, M Petruzzo, E Picatoste Olloqui, B Pietrzyk, M Pikies, D Pinci, A Pistone, A Piucci, V Placinta, S Playfer, M Plo Casasus, T Poikela, F Polci, M Poli Lener, A Poluektov, I Polyakov, E Polycarpo, G J Pomery, S Ponce, A Popov, D Popov, B Popovici, S Poslavskii, C Potterat, E Price, J Prisciandaro, C Prouve, V Pugatch, A Puig Navarro, G Punzi, C Qian, W Qian, R Quagliani, B Rachwal, J H Rademacker, M Rama, M Ramos Pernas, M S Rangel, I Raniuk, F Ratnikov, G Raven, F Redi, S Reichert, A C Dos Reis, C Remon Alepuz, V Renaudin, S Ricciardi, S Richards, M Rihl, K Rinnert, V Rives Molina, P Robbe, A B Rodrigues, E Rodrigues, J A Rodriguez Lopez, P Rodriguez Perez, A Rogozhnikov, S Roiser, A Rollings, V Romanovskiy, A Romero Vidal, J W Ronayne, M Rotondo, M S Rudolph, T Ruf, P Ruiz Valls, J J Saborido Silva, E Sadykhov, N Sagidova, B Saitta, V Salustino Guimaraes, D Sanchez Gonzalo, C Sanchez Mayordomo, B Sanmartin Sedes, R Santacesaria, C Santamarina Rios, M Santimaria, E Santovetti, A Sarti, C Satriano, A Satta, D M Saunders, D Savrina, S Schael, M Schellenberg, M Schiller, H Schindler, M Schlupp, M Schmelling, T Schmelzer, B Schmidt, O Schneider, A Schopper, H F Schreiner, K Schubert, M Schubiger, M-H Schune, R Schwemmer, B Sciascia, A Sciubba, A Semennikov, A Sergi, N Serra, J Serrano, L Sestini, P Seyfert, M Shapkin, I Shapoval, Y Shcheglov, T Shears, L Shekhtman, V Shevchenko, B G Siddi, R Silva Coutinho, L Silva de Oliveira, G Simi, S Simone, M Sirendi, N Skidmore, T Skwarnicki, E Smith, I T Smith, J Smith, M Smith, L Soares Lavra, M D Sokoloff, F J P Soler, B Souza De Paula, B Spaan, P Spradlin, S Sridharan, F Stagni, M Stahl, S Stahl, P Stefko, S Stefkova, O Steinkamp, S Stemmle, O Stenyakin, H Stevens, S Stoica, S Stone, B Storaci, S Stracka, M E Stramaglia, M Straticiuc, U Straumann, L Sun, W Sutcliffe, K Swientek, V Syropoulos, M Szczekowski, T Szumlak, S T'Jampens, A Tayduganov, T Tekampe, G Tellarini, F Teubert, E Thomas, J van Tilburg, M J Tilley, V Tisserand, M Tobin, S Tolk, L Tomassetti, D Tonelli, S Topp-Joergensen, F Toriello, R Tourinho Jadallah Aoude, E Tournefier, S Tourneur, K Trabelsi, M Traill, M T Tran, M Tresch, A Trisovic, A Tsaregorodtsev, P Tsopelas, A Tully, N Tuning, A Ukleja, A Ustyuzhanin, U Uwer, C Vacca, V Vagnoni, A Valassi, S Valat, G Valenti, R Vazquez Gomez, P Vazquez Regueiro, S Vecchi, M van Veghel, J J Velthuis, M Veltri, G Veneziano, A Venkateswaran, T A Verlage, M Vernet, M Vesterinen, J V Viana Barbosa, B Viaud, D Vieira, M Vieites Diaz, H Viemann, X Vilasis-Cardona, M Vitti, V Volkov, A Vollhardt, B Voneki, A Vorobyev, V Vorobyev, C Voß, J A de Vries, C Vázquez Sierra, R Waldi, C Wallace, R Wallace, J Walsh, J Wang, D R Ward, H M Wark, N K Watson, D Websdale, A Weiden, M Whitehead, J Wicht, G Wilkinson, M Wilkinson, M Williams, M P Williams, M Williams, T Williams, F F Wilson, J Wimberley, M A Winn, J Wishahi, W Wislicki, M Witek, G Wormser, S A Wotton, K Wraight, K Wyllie, Y Xie, Z Xing, Z Xu, Z Yang, Z Yang, Y Yao, H Yin, J Yu, X Yuan, O Yushchenko, K A Zarebski, M Zavertyaev, L Zhang, Y Zhang, A Zhelezov, Y Zheng, X Zhu, V Zhukov, S Zucchelli
A search for the rare decays B_{s}^{0}→μ^{+}μ^{-} and B^{0}→μ^{+}μ^{-} is performed at the LHCb experiment using data collected in pp collisions corresponding to a total integrated luminosity of 4.4  fb^{-1}. An excess of B_{s}^{0}→μ^{+}μ^{-} decays is observed with a significance of 7.8 standard deviations, representing the first observation of this decay in a single experiment. The branching fraction is measured to be B(B_{s}^{0}→μ^{+}μ^{-})=(3.0±0.6_{-0.2}^{+0.3})×10^{-9}, where the first uncertainty is statistical and the second systematic...
May 12, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28548474/aortic-aneurysm-endovascular-treatment-with-the-parallel-graft-technique-from-the-aortic-arch-to-the-iliac-axis
#6
Gian F Fadda, Mario Marino, Holta Kasemi, Costantino L DI Angelo, Carlo P Dionisi, Valeria Cammalleri, Carlo Setacci
BACKGROUND: The chimney technique has been developed for the treatment of complex aortic aneurysms. We analyzed the midterm to long-term outcomes of this approach from a single- centre experience. METHODS: From October 2008 to July 2016, 58 patients underwent endovascular aortic aneurysm repair using the chimney technique. Indications for treatment were thoracic aortic aneurysm (TAA) (n = 11), thoracoabdominal aortic aneurysm (TAAA) (n = 2), pararenal aortic aneurysm (PAAA) (n= 15), aortoiliac/isolated hypogastric artery aneurysm (n = 25), type I endoleak after previous TEVAR/EVAR (n=4), proximal pseudoaneurysm after AAA open repair (n = 1)...
May 26, 2017: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/28548209/improved-sampling-and-analysis-of-images-in-corneal-confocal-microscopy
#7
E L Schaldemose, F I Fontain, P Karlsson, J R Nyengaard
INTRODUCTION: Corneal confocal microscopy (CCM) is a noninvasive clinical method to analyse and quantify corneal nerve fibres in vivo. Although the CCM technique is in constant progress, there are methodological limitations in terms of sampling of images and objectivity of the nerve quantification. The aim of this study was to present a randomized sampling method of the CCM images and to develop an adjusted area-dependent image analysis. Furthermore, a manual nerve fibre analysis method was compared to a fully automated method...
May 26, 2017: Journal of Microscopy
https://www.readbyqxmd.com/read/28548010/initial-experience-with-the-6-f-and-8-f-indigo-thrombectomy-system-for-acute-renovisceral-occlusive-events
#8
Theodosios Bisdas, Konstantinos Stavroulakis, Efthymios Beropoulis, Arne Schwindt, Arne Stachmann, Martin Austermann, Giovanni Torsello
PURPOSE: To examine the safety and effectiveness of the new large-bore Indigo thrombectomy catheters to treat patients with acute renovisceral occlusion without the need of thrombolytic agents. METHODS: Between November 2015 and 2016, 7 consecutive patients (mean age 65±5 years; 5 men) with acute renovisceral artery occlusion were treated with the new large-bore (6-F and 8-F) vacuum-assisted thrombectomy catheters. The occluded vessels were 6 renal arteries and 3 superior mesenteric arteries (SMAs); 5 of the 9 thromboses were in bridging stent-grafts associated with branched endografts...
May 1, 2017: Journal of Endovascular Therapy
https://www.readbyqxmd.com/read/28547004/ocular-arterial-occlusive-disorders-and-carotid-artery-disease
#9
Sohan Singh Hayreh, M Bridget Zimmerman
OBJECTIVE: To compare prevalence of carotid artery disease and its various types of lesions in different types of ocular arterial occlusive disorders. DESIGN: Cohort study. SUBJECTS: 614 consecutive patients (728 eyes) with ocular arterial occlusive disorders. METHODS: At first visit, all patients had a detailed ophthalmic and medical history, comprehensive ophthalmic evaluation, and carotid artery evaluation (by Doppler/angiography) on the side of ocular arterial occlusion, and echocardiography...
January 2017: Ophthalmol Retina
https://www.readbyqxmd.com/read/28546594/patient-safety-reducing-the-risk-of-wrong-tooth-extraction
#10
P Cullingham, A Saksena, M N Pemberton
Over recent years there has been an increased emphasis on improving patient safety in all branches of medicine, with reducing wrong tooth extraction being a priority in dentistry. The true incidence of wrong tooth extraction is unknown but it is considered an avoidable harm and is a significant source of dental litigation. Interventions to reduce wrong tooth extraction include educational programmes encompassing human factor training, patient assisted identification, the use of checklists, marking of surgical sites and implementation of patient safety guidelines...
May 26, 2017: British Dental Journal
https://www.readbyqxmd.com/read/28546465/quantitative-mass-spectrometry-analysis-of-pd-l1-protein-expression-n-glycosylation-and-expression-stoichiometry-with-pd-1-and-pd-l2-in-human-melanoma
#11
Carlos A Morales-Betanzos, Hyoungjoo Lee, Paula I Gonzalez-Ericsson, Justin M Balko, Douglas B Johnson, Lisa J Zimmerman, Daniel C Liebler
Quantitative assessment of key proteins that control the tumor-immune interface is one of the most formidable analytical challenges in immunotherapeutics. We developed a targeted mass spectrometry (MS) platform to quantify programmed cell death-1 (PD-1), programmed cell death 1 ligand 1 (PD-L1), and programmed cell death 1 ligand 2 (PD-L2) at fmol/microgram protein levels in formalin fixed, paraffin-embedded sections from 22 human melanomas. PD-L1 abundance ranged 50-fold, from approximately 0.03 to 1.5 fmol/microgram protein and the PRM data were largely concordant with total PD-L1-positive cell content, as analyzed by immunohistochemistry (IHC) with the E1L3N antibody...
May 25, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/28546456/electrocardiographic-predictors-of-heart-failure-with-reduced-versus-preserved-ejection-fraction-the-multi-ethnic-study-of-atherosclerosis
#12
Wesley T O'Neal, Matylda Mazur, Alain G Bertoni, David A Bluemke, Mouaz H Al-Mallah, Joao A C Lima, Dalane Kitzman, Elsayed Z Soliman
BACKGROUND: Several markers detected on the routine 12-lead ECG are associated with future heart failure events. We examined whether these markers are able to separate the risk of heart failure with reduced ejection fraction (HFrEF) from heart failure with preserved ejection fraction (HFpEF). METHODS AND RESULTS: We analyzed data of 6664 participants (53% female; mean age 62±10 years) from MESA (Multi-Ethnic Study of Atherosclerosis) who were free of cardiovascular disease at baseline (2000-2002)...
May 25, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28545852/duration-of-reverse-remodeling-response-to-cardiac-resynchronization-therapy-rates-predictors-and-clinical-outcomes
#13
Takafumi Oka, Koichi Inoue, Koji Tanaka, Yuko Toyoshima, Takaaki Isshiki, Takeshi Kimura, Masakiyo Nobuyoshi, Satoshi Shizuta, Takeshi Arita, Satoki Fujii, Katsuomi Iwakura, Kenshi Fujii, Kenji Ando
BACKGROUND: A subset of patients undergoing cardiac resynchronization therapy (CRT) for heart failure (HF) with severe left ventricular (LV) dysfunction experience only short-lived LV reverse remodeling. Little is known about the incidence and prognosis of this finding. We sought to identify predictors of a brief response and investigated the prognosis in a retrospective study. METHODS: A total of 528 patients from a Japanese multicenter database with full echocardiography datasets were enrolled...
May 12, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28545444/site-specific-his-asp-phosphoproteomic-analysis-of-prokaryotes-reveals-putative-targets-for-drug-resistance
#14
Shu-Jung Lai, I-Fan Tu, Wan-Ling Wu, Jhih-Tian Yang, Louis Y P Luk, Mei-Chin Lai, Yu-Hsuan Tsai, Shih-Hsiung Wu
BACKGROUND: Phosphorylation of amino acid residues on proteins is an important and common post-translational modification in both eukaryotes and prokaryotes. Most research work has been focused on phosphorylation of serine, threonine or tyrosine residues, whereas phosphorylation of other amino acids are significantly less clear due to the controversy on their stability under standard bioanalytical conditions. RESULTS: Here we applied a shotgun strategy to analyze the histidine and aspartate phosphorylations in different microbes...
May 25, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28545281/-pre-and-post-orthotopic-heart-transplantation-electrocardiogram-characteristics-of-998-patients
#15
H Q Guan, Z J Chen, Y Zhou, J Liu, W X Sun, J Yuan, Y H Liao, N G Dong, J P Liu, K G Feng, Q Zhang, X Zhao, C Qian, F Hu
Objective: To analyze pre- and post-operation electrocardiograms (ECGs) features of patients underwent orthotopic heart transplantation (OHT), and provide evidences for identifying and analyzing post OHT ECGs. Methods: Nine hundreds and ninty-eight pre- and post- OHT standard 12-leads ECGs from 110 consecutive patients, who underwent OHT in our hospital from May 2008 to May 2014, were analyzed. Results: The mean heart rate(HR)was (86.9±16.4) beats per minute before OHT, and (100.0±0.4) beats per minute after OHT...
April 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/28544323/mass-spectrometric-evidence-for-the-modification-of-small-molecules-in-a-cobalt-60-irradiated-rodent-diet
#16
J K Prasain, L S Wilson, A Arabshahi, C Grubbs, S Barnes
The purpose of this study was to investigate the effect of radiation on the content of animal diet constituents using global metabolomics. Aqueous methanolic extracts of control and cobalt-60 irradiated NIH 7001 diets were comprehensively analyzed using nanoLC-MS/MS. Among the over two thousand ions revealed by XCMS followed by data preprocessing, 94 positive and 143 negative metabolite ions had greater than 1.5 fold changes and p-values <0.01. Use of Metaboanalyst statistical software demonstrated complete separation of the irradiated and non-radiated diets in unsupervised principal components analysis and supervised partial least squares discriminant analysis...
May 24, 2017: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/28544244/branched-chain-amino-acids-supplementation-modulates-tgf-%C3%AE-1-smad-signaling-pathway-and-interleukins-in-ccl4-induced-liver-fibrosis
#17
Naglaa F Khedr, Eman G Khedr
The alterations and low levels of circulating branched chain amino acids (BCAAs), leucine, isoleucine and valine, are associated with liver diseases. The study was designed to evaluate hepatoprotective effect of BCAAs on CCl4 -induced liver fibrosis and to investigate the molecular mechanisms underlying these effects in rats. Thirty male rats were divided into three groups. Control group (n=10), CCl4 group (n=10); rats were injected with CCl4 (1 mL/kg of 0.5:1 v/v injected i.p. twice weekly for 12 weeks). CCl4 +BCAAs group (n=10); rats were injected with similar doses of CCl4 and supplemented with a mixture of 600 mg/kg BCAAs (2: 1: 1...
May 23, 2017: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/28543265/stricter-criteria-for-left-bundle-branch-block-diagnosis-do-not-improve-response-to-crt
#18
Emanuele Bertaglia, Federico Migliore, Anna Baritussio, Antonio De Simone, Albino Reggiani, Domenico Pecora, Antonio D'Onofrio, Antonio Rapacciuolo, Gianluca Savarese, Attilio Pierantozzi, Biondino Marenna, Franco Ruffa, Monica Campari, Maurizio Malacrida, Giuseppe Stabile
BACKGROUND: Cardiac resynchronization therapy (CRT) has proved to be effective in patients with heart failure and left bundle branch block (LBBB). Recently, new ECG criteria have been proposed for the diagnosis of LBBB. These criteria are stricter than the current American Heart Association (AHA) criteria. We assessed the rate of echocardiographic response to CRT in patients with traditional LBBB versus patients who met the new criteria (strict LBBB). METHODS: Consecutive patients undergoing CRT were enrolled in the CRT MORE registry...
May 23, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28542900/the-sensory-trigeminal-complex-and-the-organisation-of-its-primary-afferents-in-the-zebra-finch-taeniopygia-guttata
#19
Macarena Faunes, J Martin Wild, Thomas Finger
Our knowledge of the avian sensory trigeminal system has been largely restricted to the principal trigeminal nucleus (PrV) and its ascending projections to the forebrain. Studies addressing the cytoarchitecture and organisation of afferent input to the sensory trigeminal complex, which includes both the PrV and the nuclei of the descending trigeminal tract (nTTD), have only been performed in pigeons and ducks. Here we extend such an analysis to a songbird, the zebra finch (Taeniopygia guttata). We describe the cytoarchitecture of the sensory trigeminal complex, the patterns of calbindin-like and substance P-like immunoreactivity, and the organisation of afferents from the three branches of the trigeminal nerve and from the lingual branch of the hypoglossal nerve...
May 24, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28542179/teaching-genetics-prior-to-teaching-evolution-improves-evolution-understanding-but-not-acceptance
#20
Rebecca Mead, Momna Hejmadi, Laurence D Hurst
What is the best way to teach evolution? As microevolution may be configured as a branch of genetics, it being a short conceptual leap from understanding the concepts of mutation and alleles (i.e., genetics) to allele frequency change (i.e., evolution), we hypothesised that learning genetics prior to evolution might improve student understanding of evolution. In the UK, genetics and evolution are typically taught to 14- to 16-y-old secondary school students as separate topics with few links, in no particular order and sometimes with a large time span between...
May 2017: PLoS Biology
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