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https://www.readbyqxmd.com/read/28425055/what-are-the-oncologic-and-functional-outcomes-after-joint-salvage-resections-for-juxtaarticular-osteosarcoma-about-the-knee
#1
Jing Li, Zhen Wang, Chuanlei Ji, Guojing Chen, Dong Liu, Haodong Zhu
BACKGROUND: Joint salvage surgery for patients with juxtaarticular osteosarcoma remains challenging, especially when the tumor invades the epiphysis. Because patients are surviving longer with current chemotherapy regimens, it is advantageous to retain native joints if possible, especially in young patients. However, the results using joint-preserving tumor resections in this context have not been well characterized. QUESTIONS/PURPOSES: (1) What are the functional outcomes after limb salvage surgery at a minimum of 3 years? (2) What are the oncologic outcomes? (3) Is joint salvage surgery for epiphyseal tumors associated with an increased risk of local recurrence compared with metaphyseal tumors not invading the epiphysis? (4) What are the complications associated with joint salvage surgery? METHODS: Between 2004 and 2013, we treated 117 patients with juxtaarticular osteosarcoma; of those, 43 (38%) were treated with joint salvage surgery, and 41 (95%) of the 43 patients are included in our study...
April 19, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28412105/how-bone-quality-may-influence-intraoperative-and-early-postoperative-problems-after-angular-stable-open-reduction-internal-fixation-of-proximal-humeral-fractures
#2
Christian Spross, Rebeca Zeledon, Vilijam Zdravkovic, Bernhard Jost
BACKGROUND: With the introduction of the deltoid tuberosity index (DTI), a simple radiographic tool has become available to measure bone mineral density of the proximal humerus. The aim of this study was to assess the influence of local bone mineral density on the early failure rate after angular stable open reduction-internal fixation of proximal humeral fractures (PHFs). METHODS: We retrospectively followed up all patients treated with angular stable implants for PHFs from 2007 to 2014...
April 12, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28401420/an-update-on-the-pathogenesis-and-treatment-of-chronic-recurrent-multifocal-osteomyelitis-in-children
#3
Andrea Taddio, Floriana Zennaro, Serena Pastore, Rolando Cimaz
Chronic recurrent multifocal osteomyelitis (CRMO), also known as chronic non-bacterial osteomyelitis (CNO), is a rare inflammatory disorder that primarily affects children. It is characterized by pain, local bone expansion, and radiological findings suggestive of osteomyelitis, usually at multiple sites. CRMO predominantly affects the metaphyses of long bones, but involvement of the clavicle or mandible are suggestive of the diagnosis. CRMO is a diagnosis of exclusion, and its pathogenesis remains unknown. Differential diagnosis includes infection, malignancies, benign bone tumors, metabolic disorders, and other autoinflammatory disorders...
April 11, 2017: Paediatric Drugs
https://www.readbyqxmd.com/read/28399323/short-stem-reverse-total-shoulder-arthroplasty-periprosthetic-type-a-fracture
#4
Bryan M Saltzman, Timothy Leroux, Michael J Collins, Thomas A Arns, Brian Forsythe
Alterations have been made over the years to the standard reverse total shoulder arthroplasty (RTSA) prosthetic components in an effort to decrease adverse events; this has led to the advent of a short humeral stem prosthesis. To the authors' knowledge, there are no reports describing the complication of a traumatic periprosthetic Wright and Cofield classification type A fracture with use of a short metaphyseal humeral stem component for RTSA. The authors describe a 49-year-old woman with this pathology who was treated with open reduction and internal fixation using a proximal humerus locking plate, unicortical and bicortical screw fixation, and a cerclage wire construct without the need to violate the shoulder joint or revise components...
April 11, 2017: Orthopedics
https://www.readbyqxmd.com/read/28394844/implant-material-type-of-fixation-at-the-shaft-and-position-of-plate-modify-biomechanics-of-distal-femur-plate-osteosynthesis
#5
Utku Kandemir, Peter Augat, Stefanie Konowalczyk Dipl-Ing, Felix Wipf Dipl-Ing, Geert von Oldenburg Dipl-Ing, Ulf Schmidt
OBJECTIVES: The purpose of this study is to investigate whether 1. the type of fixation at the shaft (hybrid vs. locking), 2. the position of the plate (offset vs. contact) and 3. the implant material has a significant effect on a) construct stiffness and b) fatigue life in a distal femur extraarticular comminuted fracture model using the same design of distal femur periarticular locking plate. METHODS: An extraarticular severely comminuted distal femoral fracture pattern (AO/OTA 33-A3) was simulated using artificial bone substitutes...
April 7, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28393960/proximal-tibial-metaphyseal-fractures-in-immature-dogs
#6
Lauren Deahl, Ron Ben-Amotz, Ana V Caceres, Kimberly A Agnello
OBJECTIVE: To describe proximal tibial metaphyseal fractures in immature dogs. MATERIALS AND METHODS: Medical records of immature dogs with metaphyseal fractures of the proximal tibia were reviewed and data were collected on signalment and history of trauma. Craniocaudal and mediolateral radiographs were evaluated for the determination of the bones fractured, location of the fracture within the bone, fracture configuration, and the presence of fracture segment displacement and angulation...
April 10, 2017: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
https://www.readbyqxmd.com/read/28390287/influence-of-the-fixation-region-of-a-press-fit-hip-endoprosthesis-on-the-stress-strain-state-of-the-bone-implant-system
#7
Ievgen Levadnyi, Jan Awrejcewicz, Márcio Fagundes Goethel, Alexander Loskutov
Although significant progress has been made in the development of total hip replacement, behaviour of the femoral component of an endoprosthesis in relation to the type of its fixation in the bone is still not fully understood. In this paper, behaviour of the femoral bone and the stem prosthesis is studied taking into account different types of prosthesis fixation in the medullary canal of the femur under the action of functional loads. For an analysis, a three-dimensional model of a femur has been developed based on the results of a computed tomography...
April 2, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28389261/an-engineering-paradigm-in-the-biomedical-sciences-knowledge-as-epistemic-tool
#8
REVIEW
Mieke Boon
In order to deal with the complexity of biological systems and attempts to generate applicable results, current biomedical sciences are adopting concepts and methods from the engineering sciences. Philosophers of science have interpreted this as the emergence of an engineering paradigm, in particular in systems biology and synthetic biology. This article aims at the articulation of the supposed engineering paradigm by contrast with the physics paradigm that supported the rise of biochemistry and molecular biology...
April 4, 2017: Progress in Biophysics and Molecular Biology
https://www.readbyqxmd.com/read/28386944/growth-and-shaping-of-metacarpal-and-carpal-cartilage-anlagen-application-of-morphometry-to-the-development-of-short-and-long-bone-a-study-of-human-hand-anlagen-in-the-fetal-period
#9
Ugo E Pazzaglia, Terenzio Congiu, Valeria Sibilia, Lavinia Casati, Andrea Minini, Anna Benetti
A histological and morphometric analysis of human metacarpal and carpal anlagen between the 16th and 22nd embryonic weeks was carried out with the aim of studying the establishment of the respective anlage architecture. No differences in the pattern of growth were documented between the peripheral and central zones of the metacarpal epiphyses and those of the carpals. The regulation of longitudinal growth in long bone anlagen occurred in the transition zone between the epiphysis and the diaphysis (homologous to the metaphyseal growth plate cartilage in more advanced developmental stage of the bone)...
April 7, 2017: Journal of Morphology
https://www.readbyqxmd.com/read/28383417/short-double-elastic-nailing-of-severely-displaced-distal-pediatric-radial-fractures-a-new-method-for-stable-fixation
#10
Marcell Varga, Gergő Józsa, Balázs Fadgyas, Tamás Kassai, Antal Renner
RATIONALE: Short double elastic nailing is a minimal invasive, modified ESIN (elastic stable intramedullary nailing) technique for severely displaced distal radial fracture in children. The aim of this technical report is to introduce our new method and evaluate the final results of the procedure. PATIENT CONCERNS: We reviewed retrospectively 24 patients who underwent short double elastic nailing due to distal radial fractures between November 2012 and December 2015...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28381356/blocking-screws-for-alignment-control-in-intramedullary-limb-lengthening
#11
Julian Fürmetz, Stefan Bösl, James Schilling, Florian Wolf, Nikolaus Degen, Peter H Thaller
Simultaneous deformity correction in the frontal and sagittal plane becomes more and more an important part of intramedullary lengthening to avoid further operative procedures. Such as in fracture treatment blocking screws can be used for alignment control if osteotomy is performed in the metaphyseal bone. 31 intramedullary lengthening procedures between 2009 and 2011 were retrospectively analysed for precision of simultaneous deformity correction. The average planned correction to the HKA was 2.4° (0.1°-8...
March 31, 2017: Injury
https://www.readbyqxmd.com/read/28379908/effects-of-long-term-high-load-exercise-on-the-anatomy-of-the-hip-joints-a-preliminary-report
#12
Yawei Song, Xiyuan Zhang, Ke Rong
The aim of this study was to assess the impact of different sports on hip joint anatomic parameters in athletes. This was a cross-sectional study of eight male trampolinists, eight male weightlifters, and eight male volunteers enrolled in July 2014. Hip joint anatomic parameters were measured from plain radiographs taken at the level of the lesser trochanter center. Data were compared between groups using the χ-test or one-way analysis of variance with the Bonferroni post-hoc test. There were no significant differences among groups in age, height, or weight...
April 4, 2017: Journal of Pediatric Orthopedics. Part B
https://www.readbyqxmd.com/read/28377086/differentiating-and-defusing-theoretical-ecology-s-criticisms-a-rejoinder-to-sagoff-s-reply-to-donhauser-2016
#13
Justin Donhauser
In a (2016) paper in this journal, I defuse allegations that theoretical ecological research is problematic because it relies on teleological metaphysical assumptions. Mark Sagoff offers a formal reply. In it, he concedes that I succeeded in establishing that ecologists abandoned robust teleological views long ago and that they use teleological characterizations as metaphors that aid in developing mechanistic explanations of ecological phenomena. Yet, he contends that I did not give enduring criticisms of theoretical ecology a fair shake in my paper...
April 1, 2017: Studies in History and Philosophy of Biological and Biomedical Sciences
https://www.readbyqxmd.com/read/28376853/a-large-giant-cell-tumor-of-the-larynx-case-report-and-review-of-the-literature
#14
Andrew Arndt, Rachelle LeBlanc, Peter Spafford
BACKGROUND: Giant cell tumors (GCTs) are typically found in the metaphyseal-epiphyseal area of long bones but can also occur in the head and neck region. GCT of the larynx is a rare entity with only 42 reported cases in the international literature. Furthermore, to the best of our knowledge this is the largest laryngeal GCT reported in the literature to date. GCT of the larynx can present with dysphonia, dyspnea, and/or dysphagia and should be considered in the differential diagnosis of a neck mass...
April 4, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28371496/osteogenic-ability-detection-of-human-bone-morphogenetic-protein-2-gene-activated-nano-bone-putty-by-reusable-double-cavity-bone-harvest-chamber
#15
Li Sun, Zhi-Hui Yan, Xian-Teng Yang, Tai-Zhe Wang, Qin Yang, Sen-Lei Li, Ying-Jie Nie, Xiao-Bin Tian
OBJECTIVE: To explore the feasibility of implanting a self-designed reusable double-cavity bone harvest chamber into Guizhou mini-pigs for observation of the osteogenic effect of human bone morphogenetic protein-2 (hBMP-2) gene-activated nano bone putty on bone in growth. METHODS: Eight healthy 12-month-old female Guizhou mini-pigs were used for the present experiment. In the first operation, empty double-cavity bone harvest chambers (n = 8) were implanted into the femoral metaphysis of the animals as a blank control group...
February 2017: Orthopaedic Surgery
https://www.readbyqxmd.com/read/28351338/dbm-as-a-carrier-for-bmp-2-burst-release-combined-with-long-term-binding-and-osteoinductive-activity-evaluated-in-vitro-and-in-vivo
#16
Elisabeth Huber, Anne-Marie Pobloth, Nicole Bormann, Nicolai Kolarczik, Katharina Schmidt-Bleek, Hanna Schell, Philipp Schwabe, Georg Duda, Britt Wildemann
To allow bone defect regeneration, autologous bone grafting still represents the gold standard. However, autograft harvesting has limitations including an additional surgery, donor site morbidity and limited availability. Demineralized bone matrix (DBM) would represent an alternative, yet lacks sufficient osteoinductive properties. Combining DBM with a potent agent such as bone morphogenetic protein-2 (BMP-2) might be a feasible alternative approach, optimizing an established grafting material with strong osteoinductive properties...
March 29, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28342220/prenatal-course-of-metaphyseal-anadysplasia-associated-with-homozygous-mutation-in-mmp9-identified-by-exome-sequencing
#17
Reuven Sharony, Zvi Borochowitz, Lior Cohen, Atalia Storch, Revital Rosenfeld, Shira Modai, Eyal Reinstein
Metaphyseal anadysplasia (MANDP) is a rare autosomal recessive form of skeletal dysplasia characterized by normal length at birth and transitory bowing of the legs. Although several families with MANDP have been reported, homozygous mutations in the matrix metalloproteinase type 9 (MMP9) gene have been described in only one consanguineous family, and thus the pre and postnatal phenotypic spectrum is still obscure. A clinically similar but more severe type is caused by autosomal-dominant inheritance and is caused by mutations in matrix metalloproteinase type 13 gene (MMP13)(...
March 25, 2017: Clinical Genetics
https://www.readbyqxmd.com/read/28341184/global-fit-concept-in-revision-hip-arthroplasty-for-cementless-press-fit-femoral-stems
#18
F Canovas, P LeBeguec, J Batard, F Gaillard, L Dagneaux
A revision stem may be required after a femoral extended trochanteric osteotomy (ETO) is made during revision hip arthroplasty. The two main complications of straight cementless femoral stems are subsidence due to inadequate osteointegration and stress-shielding. We will describe an original revision method with ETO that uses a straight cementless stem. The goal of this method was to achieve the most extensive press-fit possible during stem implantation to improve the transmission of stresses to the bone and to prevent reduction in bone density...
March 21, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28339360/critical-role-of-stir-mri-in-early-detection-of-post-streptococcal-periostitis-with-dysproteinaemia-goldbloom-s-syndrome
#19
Riccardo Papa, Alessandro Consolaro, Francesca Minoia, Roberta Caorsi, Gianmichele Magnano, Marco Gattorno, Angelo Ravelli, Paolo Picco
OBJECTIVES: In 1966, Goldbloom et al. described two children who developed a peculiar clinical picture characterized by intermittent daily bone pain in the lower limbs, fever spikes, increased acute phase reactants and dysproteinaemia. The syndrome occurred two weeks after a group A β-haemolytic streptococcus infection. So far, only a few cases have been reported in the medical literature in English. METHODS: We report two further cases of Goldbloom's syndrome with a review of the literature in English...
March 23, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28337505/osteochondroma-causing-cervical-spinal-cord-compression
#20
Ryunosuke Fukushi, Makoto Emori, Noriyuki Iesato, Masanobu Kano, Toshihiko Yamashita
Osteochondromas are the most common benign tumors of the bone. They occur in young adolescent patients and are frequently located in the metaphyses of the long bones; they do not grow after skeletal maturity. The incidence of osteochondroma in the spine is reported to be rare. Moreover, patients with spinal osteochondroma who develop symptoms of myelopathy are extremely rare. We report the case of an 8-year-old girl who experienced myelopathy due to spinal compression of the cervical osteochondroma. This case suggests that if a cartilage cap is observed on the spinal canal with magnetic resonance imaging (MRI), the tumor may extend to the spinal canal, resulting in neurologic dysfunction...
March 23, 2017: Skeletal Radiology
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