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https://www.readbyqxmd.com/read/28808739/an-intracortical-chondromyxoid-fibroma-in-the-diaphysis-of-the-metatarsal
#1
Ji Sung Han, Euddeum Shim, Baek Hyun Kim, Jung-Woo Choi
Chondromyxoid fibromas (CMFs) are rare, benign, primary tumors of bones, and occur in the metaphyses of the medullary canals of the long bones. The occurrence of intracortical CMFs is extremely rare. Very few cases of intracortical CMFs located in the long tubular bones have been reported to date. Moreover, even though the feet are the second most common site for CMF (after the knees), intracortical metatarsal CMF has not been reported previously, to our knowledge. We report an intracortical CMF occurring in the diaphysis of the metatarsal in a 17-year-old man...
August 15, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28806499/hibernating-little-pocket-mice-show-few-seasonal-changes-in-bone-properties
#2
Noellyn Pineda, Marjorie Owen, Claire Tucker, Sam Wojda, Stanley Kitchen, Hal Black, Seth Donahue
Periods of disuse or physical inactivity increase bone porosity and decrease bone mineral density, resulting in a loss of bone mechanical competence in many animals. Although large hibernators like bears and marmots prevent bone loss during hibernation, despite long periods of physical inactivity, some small hibernators do lose bone during hibernation. Little pocket mice (Perognathus longimembris) remain underground during winter hibernation and undergo bouts of torpor and interbout arousals, but the torpor bout duration is shorter than other rodent hibernators...
August 14, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/28802725/body-mass-estimation-in-hominoids-age-and-locomotor-effects
#3
M Loring Burgess, Shannon C McFarlin, Antoine Mudakikwa, Michael R Cranfield, Christopher B Ruff
While there are a number of methods available for estimation of body mass in adult nonhuman primates, very few are available for juveniles, despite the potential utility of such estimations in both analyses of fossils and in museum collection based research. Furthermore, because of possible scaling differences, adult based body mass estimation equations may not be appropriate for non-adults. In this study, we present new body mass estimation equations for both adult and immature nonhuman hominoids based on joint and metaphyseal dimensions...
August 9, 2017: Journal of Human Evolution
https://www.readbyqxmd.com/read/28802724/juvenile-body-mass-estimation-a-methodological-evaluation
#4
Libby Cowgill
Two attempts have been made to develop body mass prediction formulae specifically for immature remains: Ruff (Ruff, C.C., 2007, Body size prediction from juvenile skeletal remains. American Journal Physical Anthropology 133, 698-716) and Robbins et al. (Robbins, G., Sciulli, P.W., Blatt, S.H., 2010. Estimating body mass in subadult human skeletons. American Journal Physical Anthropology 143, 146-150). While both were developed from the same reference population, they differ in their independent variable selection: Ruff (2008) used measures of metaphyseal and articular surface size to predict body mass in immature remains, whereas Robbins et al...
August 9, 2017: Journal of Human Evolution
https://www.readbyqxmd.com/read/28802414/management-of-resistant-distal-femur-non-unions-with-allograft-strut-and-autografts-combined-with-osteosynthesis-in-a-series-of-22-patients
#5
Raja Bhaskara Kanakeshwar, Dheenadhayalan Jayaramaraju, Devendra Agraharam, Shanmuganathan Rajasekaran
INTRODUCTION AND PURPOSE: Challenges to the surgeon in managing cases of resistant non-union of the distal femur include poor bone stock, disuse osteopenia and joint contractures. Procedures varying from simple bone grafting to megaprosthesis revision have been described. We successfully managed such cases using our technique of combining cortical allograft struts to augment the defect in the femoral condyle coupled with autogenous iliac crest bone grafting and locking plate osteosynthesis...
August 2017: Injury
https://www.readbyqxmd.com/read/28800854/up-to-seven-years-follow-up-of-short-cemented-stems-in-complex-primary-total-knee-arthroplasty-a-prospective-study
#6
Mathieu Angers-Goulet, Martin Bédard
BACKGROUND: Although primary total knee arthroplasty (TKA) shows good clinical, functional and radiological results, it can be complicated by certain conditions or pathologies. The main objective of this study was to evaluate the global performance of short cemented metaphyseal stem components in patients undergoing complex primary TKA. METHODS: This is a single-surgeon prospective case series of 91 patients who underwent complex primary TKA requiring short stem fixation between January 2009 and October 2014...
August 8, 2017: Knee
https://www.readbyqxmd.com/read/28794403/chronological-immunolocalization-of-sclerostin-and-fgf23-in-the-mouse-metaphyseal-trabecular-and-cortical-bone
#7
Atsunaka Sakurai, Tomoka Hasegawa, Ai Kudo, Zhao Shen, Tomoya Nagai, Miki Abe, Taiji Yoshida, Hiromi Hongo, Tomomaya Yamamoto, Tsuneyuki Yamamoto, Kimimitsu Oda, Paulo Henrique Luiz de Freitas, Minqi Li, Hidehiko Sano, Norio Amizuka
To assess the chronological participation of sclerostin and FGF23 in bone metabolism, this study tracked the immunolocalization of sclerostin and FGF23 in the metaphyses of murine long bones from embryonic day 18 (E18) through 1 day after birth, 1 week, 2 weeks, 4 weeks, 8 weeks, and 20 weeks of age. We have selected two regions in the metaphyseal trabeculae for assessing sclerostin and FGF23 localization: close to the chondro-osseous junction, i.e., bone modeling site even in the adult animals, and the trabecular region distant from the growth plate, where bone remodeling takes place...
2017: Biomedical Research
https://www.readbyqxmd.com/read/28793006/osteointegration-of-porous-absorbable-bone-substitutes-a-systematic-review-of-the-literature
#8
Maria Júlia Escanhoela Paulo, Mariana Avelino Dos Santos, Bruno Cimatti, Nelson Fabrício Gava, Marcelo Riberto, Edgard Eduard Engel
Biomaterials' structural characteristics and the addition of osteoinductors influence the osteointegration capacity of bone substitutes. This study aims to identify the characteristics of porous and resorbable bone substitutes that influence new bone formation. An Internet search for studies reporting new bone formation rates in bone defects filled with porous and resorbable substitutes was performed in duplicate using the PubMed, Web of Science, Scielo, and University of São Paulo Digital Library databases...
July 2017: Clinics
https://www.readbyqxmd.com/read/28782619/differential-responses-of-mechanosensitive-osteocyte-proteins-in-forelimbs-and-hindlimbs-in-hindlimb-unloaded-rats
#9
Corinne E Metzger, Jessica E Brezicha, Jon P Elizondo, S Anand Narayanan, Harry A Hogan, Susan A Bloomfield
Osteocytes are believed to be the primary mechanosensors of bone tissue, signaling to osteoblasts and osteoclasts by releasing specific proteins. Sclerostin, interleukin-6 (IL-6), and insulin-like growth factor-I (IGF-I) are osteocyte proteins that signal to osteoblasts. This study's goals are to determine if osteocyte protein response to mechanical unloading is restricted to the unloaded bone using the hindlimb unloading (HU) rodent model. We also examined tumor necrosis factor-α (TNF-α) due to its interactions with all three osteocyte proteins...
August 3, 2017: Bone
https://www.readbyqxmd.com/read/28780005/the-role-of-the-periosteal-sleeve-in-the-reconstruction-of-bone-defects-using-a-non-vascularised-fibula-graft-in-the-pediatric-population
#10
N Christina Steiger, Pierre Journeau, Pierre Lascombes
BACKGROUND: Following resection of large benign bone tumors surgeons are confronted with bone defects severely affecting the stability of a limb. To restore the mechanical continuity of the bone different treatment methods using bone grafts have been described. In pediatric patients the thick periosteal sleeve is thought to contribute to bone formation. HYPOTHESIS: An intact periosteal sleeve is crucial in bone remodelling around a non-vascularised fibular graft used to bridge large bone defects...
August 2, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28770512/immediate-intensive-mobilization-compared-with-immediate-conventional-mobilization-for-the-impacted-osteoporotic-conservatively-treated-proximal-humeral-fracture-a-randomized-controlled-trial
#11
S Carbone, C Razzano, P Albino, R Mezzoprete
PURPOSE: To select in a 2-year survey of proximal humerus fractures accessing the emergency department, a population of osteoporotic stable impacted fractures and to randomize them into two groups, one with an immediate intensive mobilization program and the other with an immediate conventional mobilization program. METHODS: In emergency department, patients with clinical signs of shoulder girdle fracture were submitted to standard X-ray examination and CT scan...
August 2, 2017: Musculoskeletal Surgery
https://www.readbyqxmd.com/read/28763161/monoallelic-fgfr3-and-biallelic-alpl-mutations-in-a-thai-girl-with-hypochondroplasia-and-hypophosphatasia
#12
Thantrira Porntaveetus, Chalurmpon Srichomthong, Kanya Suphapeetiporn, Vorasuk Shotelersuk
Skeletal dysplasias are a complex group of more than 350 disorders with phenotypic and genotypic heterogeneity affecting bone and cartilage growth. We studied a 2-year-old girl and her 21-year-old mother with disproportionate short stature. In addition to typical features of hypochondroplasia found in both patients, the child had deformities of the extremity bones, metaphyseal flares, and bilateral transverse (Bowdler) fibular spurs with overlying skin dimples detected at birth. Intravenous pamidronate was started in the child since the age of 17 days, and then every two months...
August 1, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28757489/the-metaphysics-of-morris-r-cohen-from-realism-to-objective-relativism
#13
Lawrence Cahoone
Morris Cohen is mainly remembered as a philosopher of history and law, a friend of jurists (Oliver Wendell Holmes, Felix Frankfurter), and a teacher of more prominent philosophers (e.g., Ernest Nagel, Paul Weiss, Morton White). But his unique position as a student of the work of Russell and Peirce led him to make a distinctive contribution to the debate over realism in in the 1910s. Largely ignored and completely uncited, his early papers formulated what would later be called "objective relativism," influencing the later work of Columbia naturalism, hence American philosophy, from the 1940s to the 1960s...
2017: Journal of the History of Ideas
https://www.readbyqxmd.com/read/28754445/predictive-power-of-distal-radial-metaphyseal-tenderness-for-diagnosing-occult-fracture
#14
Steven Z Glickel, Lauren Hinojosa, Claire M Eden, Elaine Balutis, O Alton Barron, Louis W Catalano
PURPOSE: To correlate the physical examination finding of distal radial metaphyseal tenderness with plain radiographic and magnetic resonance imaging after acute wrist injury to diagnose occult distal radius fractures. We hypothesized that persistent distal radial metaphyseal tenderness 2 weeks after acute injuries is predictive of an occult fracture. METHODS: Twenty-nine adult patients presented, after acute trauma, with distal radial metaphyseal tenderness and initial plain radiographs and/or fluoroscopic images that did not show a distal radius fracture...
July 26, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28748325/the-sense-of-quality-of-life-and-religious-strategies-of-coping-with-stress-in-prison-inmates
#15
Elżbieta Talik, Bartłomiej Skowroński
The aim of the presented research was to analyze differences in religious strategies of coping with stress in a group of prison inmates characterized by different levels of the sense of quality of life-general, psychophysical, psychosocial, personal, and metaphysical. The participants were 390 males, aged 19-68 years, serving sentences in prisons in Poland. The measures used were the Sense of Quality of Life Questionnaire by M. Straś-Romanowska and K. I. Pargament's RCOPE Questionnaire. As expected, individuals with a high sense of quality of life-both general and pertaining to specific dimensions-more often chose positive religious strategies, whereas participants with a low sense of quality of life more often chose negative strategies...
July 26, 2017: Journal of Religion and Health
https://www.readbyqxmd.com/read/28748013/chondroblastic-osteosarcoma-of-the-distal-tibia-a-rare-case-report
#16
Aymen Ben Fredj, Lassaad Hassini, Aymen Fekih, Mohamed Allagui, Issam Aloui, Abderrazek Abid
Chondroblastic osteosarcoma, representing about 25% of osteosarcoma, is a fatal primary malignancy of the skeleton if not diagnosed and treated appropriately. It most commonly occurs in the long bones of the extremities near the metaphyseal growth plates. In this report, we describe the occurrence of chondroblastic osteosarcoma involving the left distal tibia in a 14-year-old male. The diagnosis was confirmed by the histological examination of a surgical biopsy. The patient was treated by both surgery and neoadjuvant chemotherapy...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28742517/type-1-rhizomelic-chondrodysplasia-punctata-with-a-homozygous-pex7-mutation
#17
Nursel Muratoğlu Şahin, Meliha Esra Bilici, Erdal Kurnaz, Melek Pala Akdoğan, Serdar Ceylaner, Zehra Aycan
BACKGROUND: Rhizomelic chondrodysplasia punctata (RCDP) is a rare peroxisomal disease characterised by punctate calcifications of non-ossified cartilage epiphyseal centres. The main biochemical marker of all RCDP types is a decrease in the levels of plasmalogens. Additionally, the accumulation of phytanic acid can be used as a differential marker between types of RDCP. Due to the biochemical overlap between types 1 and 5 RCDP, a genetic analysis of these genes should be performed in patients to identify the type...
August 28, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28740483/a-case-with-spondyloenchondrodysplasia-treated-with-growth-hormone
#18
Takanori Utsumi, Satoshi Okada, Kazushi Izawa, Yoshitaka Honda, Gen Nishimura, Ryuta Nishikomori, Rika Okano, Masao Kobayashi
Spondyloenchondrodysplasia (SPENCD) is an autosomal recessive skeletal dysplasia caused by loss of function mutations in acid phosphatase 5, tartrate resistant (ACP5). Hypomorphic ACP5 mutations impair endochondral bone growth and create an interferon (INF) signature, which lead to distinctive spondylar and metaphyseal dysplasias, and extraskeletal morbidity, such as neurological involvement and immune dysregulation, respectively. We report an affected boy with novel ACP5 mutations, a splice-site mutation (736-2 A>C) and a nonsense mutation (R176X)...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28739417/neutron-tomographic-imaging-of-bone-implant-interface-comparison-with-x-ray-tomography
#19
Hanna Isaksson, Sophie Le Cann, Christina Perdikouri, Mikael J Turunen, Anders Kaestner, Magnus Tägil, Stephen A Hall, Erika Tudisco
Metal implants, in e.g. joint replacements, are generally considered to be a success. As mechanical stability is important for the longevity of a prosthesis, the biological reaction of the bone to the mechanical loading conditions after implantation and during remodelling determines its fate. The bone reaction at the implant interface can be studied using high-resolution imaging. However, commonly used X-ray imaging suffers from image artefacts in the close proximity of metal implants, which limit the possibility to closely examine the bone at the bone-implant interface...
July 22, 2017: Bone
https://www.readbyqxmd.com/read/28738883/recurrent-c-g1636a-p-g546s-mutation-of-col2a1-in-a-chinese-family-with-skeletal-dysplasia-and-different-metaphyseal-changes-a-case-report
#20
Jing Chen, Xiaomin Ma, Yulin Zhou, Guimei Li, Qiwei Guo
BACKGROUND: Mutations in the COL2A1 gene cause type II collagenopathies characterized by skeletal dysplasia with a wide spectrum of phenotypic severity. Most COL2A1 mutations located in the triple-helical region, and the glycine to bulky amino acid substitutions (e.g., glycine to serine) in the Gly-X-Y repeat were identified frequently. However, the same COL2A1 mutations are associated with different phenotypes and the genotype-phenotype relationship is still poorly understood. Therefore, the studies of more patients about the recurrent mutations in COL2A1 will be needed for further research to provide more comprehensive clinical and genetic data...
July 24, 2017: BMC Pediatrics
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