keyword
https://read.qxmd.com/read/33112052/the-mechanisms-associated-with-reflux-episodes-in-ambulant-subjects-with-gastro-esophageal-reflux-disease
#21
JOURNAL ARTICLE
Paola Iovino, Byron Theron, Sandra Prew, Shyam Menon, Nigel Trudgill
BACKGROUND: The mechanisms associated with gastro-esophageal reflux (GER) episodes were studied using combined High-resolution Impedance Manometry (HRIM) and pH monitoring in ambulant subjects with different patterns of GERD. METHODS: Sixteen subjects with mild-moderate esophagitis (Los Angeles (LA) grade A&B) (group A) and 11 subjects with severe esophagitis (LA grade C&D) or Barrett's esophagus (BE) were studied before and after a meal, resting, while walking, and during standardized exercise, using a HRIM and a pH probe...
April 2021: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://read.qxmd.com/read/33090008/muscle-tension-dysphagia-contributing-factors-and-treatment-efficacy
#22
JOURNAL ARTICLE
Christina H Kang, Nan Zhang, David G Lott
OBJECTIVE: To determine factors contributing to disease etiology and treatment efficacy. STUDY DESIGN: Original Report. SETTING: Tertiary academic center. METHODS: IRB approved prospective study of 20 patients with reported dysphagia who exhibited normal oropharyngeal and esophageal swallowing function as evidenced by videofluoroscopic swallow study, esophagogastroduodenoscopy, high-resolution esophageal manometry with stationary impedance, and Bravo pH probe off proton pump inhibitor...
July 2021: Annals of Otology, Rhinology, and Laryngology
https://read.qxmd.com/read/32904698/esophageal-peroral-endoscopic-myotomy-poem-for-treatment-of-esophagogastric-junction-outflow-obstruction-results-from-the-first-prospective-trial
#23
JOURNAL ARTICLE
Yervant Ichkhanian, Omid Sanaei, Andrew Canakis, Kia Vosoughi, Erik Almazan, Bachir Ghandour, Mouen A Khashab
Background and study aims  Esophagogastric junction outflow obstruction (EGJOO) is a rare esophageal dysmotility disease that is characterized by elevated integrated relaxation pressuse (IRP) with evidence of preserved peristalsis. The role of peroral endoscopic myotomy (POEM) in management of EGJOO is currently unknown. Patients and methods  This is a prospective trial conducted in a single US tertiary care center from June 2015 to June 2019. Symptomatic patients, diagnosed with EGJOO on both HRM and endoluminal functional lumen imaging probe (EndoFLIP), who were eligible for POEM were recruited...
September 2020: Endoscopy International Open
https://read.qxmd.com/read/32895009/diagnostic-utility-of-salivary-pepsin-as-compared-with-24-hour-dual-ph-impedance-probe-in-laryngopharyngeal-reflux
#24
COMPARATIVE STUDY
Michael Zhang, Clemente Chia, Claire Stanley, Debra J Phyland, Paul M Paddle
OBJECTIVE: Laryngopharyngeal reflux (LPR) is defined as the retropulsion of gastric contents into the larynx, oropharynx, and/or nasopharynx. The 24-hour combined hypopharyngeal-esophageal multichannel intraluminal impedance with dual pH probe (24h-HEMII-pH) is currently the gold standard in LPR diagnosis; however, it is invasive, user dependent, and not always tolerated. This study assesses the diagnostic utility of salivary pepsin (Peptest) at different thresholds and during symptomatic periods as compared with the 24h-HEMII-pH probe in diagnosing LPR...
February 2021: Otolaryngology—Head and Neck Surgery
https://read.qxmd.com/read/32428279/diagnosis-of-gastroesophageal-reflux-an-update-on-current-and-emerging-modalities
#25
REVIEW
Daphne Ang, Yeong-Yeh Lee, John O Clarke, Kristle Lynch, Alexandra Guillaume, Frances Onyimba, Afrin Kamal, C Prakash Gyawali
Gastroesophageal reflux disease (GERD) is a common condition characterized by troublesome symptoms or esophageal mucosal lesions attributed to excessive esophageal acid exposure. Various pathophysiological mechanisms account for GERD, including impaired esophageal peristalsis and anatomical or physiological defects at the esophagogastric junction (EGJ). Endoscopy identifies GERD complications and detects potential alternative diagnoses. However, if symptoms persist despite proton pump inhibitor therapy, functional esophageal tests are useful to characterize reflux burden and define the symptom association profile...
December 2020: Annals of the New York Academy of Sciences
https://read.qxmd.com/read/32280407/a-new-noninvasive-accelerometric-method-for-diagnosing-acid-andnon-acid-gastroesophageal-reflux-in-premature-infants-proof-of-concept
#26
JOURNAL ARTICLE
Ira H Gewolb, Frank L Vice
Non-acid reflux is common in premature neonates. Current methods of diagnosing gastroesophageal reflux (GER) such as pH probes, multichannel impedance monitoring, X-rays, or endoscopy are either invasive or unable to diagnose non-acid reflux. Passage of a naso-esophageal tube is uncomfortable. Imaging studies are of short duration and may miss reflux entirely. Herein, we present proof of concept of a noninvasive accelerometric device that detects acid and non-acid reflux in premature infants. An accelerometer was taped over the subxiphoid process in patients suspected of having GER who were already scheduled for pH probe or multichannel impedance monitoring...
December 1, 2019: Journal of Medical Devices
https://read.qxmd.com/read/31848064/does-the-reflux-symptom-index-predict-increased-pharyngeal-events-on-hemii-ph-testing-and-correlate-with-general-quality-of-life
#27
JOURNAL ARTICLE
Elliana Kirsh DeVore, Walter W Chan, Jennifer J Shin, Thomas L Carroll
OBJECTIVES: To determine the ability of the reflux symptom index (RSI) to predict objective impedance and pH-probe testing, and to examine the relationship between disease-specific and general health status in patients diagnosed with laryngopharyngeal reflux (LPR). METHODS: Adults presenting to a tertiary care academic center with a primary voice complaint completed the RSI and the Patient-Reported Outcomes Measurement Information System 10-item global health instrument (PROMIS)...
December 14, 2019: Journal of Voice
https://read.qxmd.com/read/31620651/gastroesophageal-reflux-in-cystic-fibrosis-across-the-age-spectrum
#28
JOURNAL ARTICLE
Frederick W Woodley, Don Hayes, Benjamin T Kopp, Melissa Moore-Clingenpeel, Rodrigo Strehl Machado, Christopher J Nemastil, Sudarshan Jadcherla, Carlo Di Lorenzo, Ajay Kaul, Hayat Mousa
Background: Scientific advances have improved longevity in cystic fibrosis (CF) patients and many of these patients can expect to experience age-related gastrointestinal co-morbidities. We aimed to assess the extent to which age might impact gastroesophageal reflux (GER) in patients with CF. Methods: Our esophageal pH-multichannel intraluminal impedance monitoring database was searched for tracings belonging to CF patients ≥2 years old without prior fundoplication and not taking anti-reflux medications immediately prior (within 7 days) and during the study...
2019: Translational Gastroenterology and Hepatology
https://read.qxmd.com/read/31587540/esophageal-motor-dysfunctions-in-gastroesophageal-reflux-disease-and-therapeutic-perspectives
#29
REVIEW
Sihui Lin, Hua Li, Xiucai Fang
Gastroesophageal reflux disease (GERD) is a very common disease, and the prevalence in the general population has recently increased. GERD is a chronic relapsing disease associated with motility disorders of the upper gastrointestinal tract. Several factors are implicated in GERD, including hypotensive lower esophageal sphincter, frequent transient lower esophageal sphincter relaxation, esophageal hypersensitivity, reduced resistance of the esophageal mucosa against the refluxed contents, ineffective esophageal motility, abnormal bolus transport, deficits initiating secondary peristalsis, abnormal response to multiple rapid swallowing, and hiatal hernia...
October 30, 2019: Journal of Neurogastroenterology and Motility
https://read.qxmd.com/read/30944563/esophageal-impedance-ph-monitoring-and-pharyngeal-ph-monitoring-in-the-diagnosis-of-extraesophageal-reflux-in-children
#30
JOURNAL ARTICLE
Anna Plocek, Beata Gębora-Kowalska, Jakub Białek, Wojciech Fendler, Ewa Toporowska-Kowalska
Various clinical symptoms are attributed to extraesophageal reflux disease (EERD). Multichannel intraluminal impedance-pH monitoring (MII-pH) is considered to correlate symptoms with acid and nonacid gastroesophageal reflux (GER) events. Pharyngeal pH monitoring (Dx-pH) is considered to correlate the decrease in the pH level in the oropharynx with reported symptoms and to diagnose supraesophageal reflux. We aimed to assess the correlation between acid reflux episodes recorded by Dx-pH and GER detected via MII-pH in children with suspected EERD...
2019: Gastroenterology Research and Practice
https://read.qxmd.com/read/30712156/new-developments-in-esophageal-motility-testing
#31
REVIEW
Rena Yadlapati, Glenn T Furuta, Paul Menard-Katcher
PURPOSE OF REVIEW: The purpose of this review is to present the latest developments in esophageal motility testing and summarize the current paradigm of esophageal motility disorders. RECENT FINDINGS: While high-resolution esophageal pressure topography interpreted according to the Chicago Classification represents the gold standard to evaluate esophageal motility, recent studies highlight the additional value of novel manometric applications. Novel applications include provocative measures to assess for obstructive physiology at the esophagogastric junction (EGJ), esophageal peristaltic reserve, and rumination and supragastric belching disorders...
March 2019: Current Treatment Options in Gastroenterology
https://read.qxmd.com/read/30288952/evaluating-the-yield-of-gastrointestinal-testing-in-pediatric-patients-in-aerodigestive-clinic
#32
JOURNAL ARTICLE
Emily M DeBoer, Sarah Kinder, Alison Duggar, Jeremy D Prager, Jason Soden, Robin R Deterding, Amanda G Ruiz, Emily L Jensen, Jason Weinman, Todd Wine, John E Fortunato, Joel A Friedlander
OBJECTIVE: To improve understanding of the interrelatedness of airway and esophageal diagnoses by evaluating the yield of procedural and radiographic testing of the gastrointestinal tract in children with airway conditions by their referring diagnoses in a pediatric aerodigestive clinic. METHODS: A retrospective chart review of all 325 patients seen in the aerodigestive program from 2010 to 2013 was performed in a single academic medical center. Demographics and results from esophagogastroduodenoscopies with biopsies (EGD), upper gastrointestinal fluoroscopy studies (UGI), and pH multichannel intraluminal impedance probe (pH-MII) performed within 30 days of the clinic visit were evaluated according to presenting diagnoses...
November 2018: Pediatric Pulmonology
https://read.qxmd.com/read/30268301/the-role-of-novel-functional-probes-in-the-evaluation-and-treatment-of-esophageal-disease
#33
REVIEW
Ezra N Teitelbaum, Christy M Dunst
The understanding of esophageal function and dysfunction in a variety of disease states has been driven largely by the introduction of a variety of measurement technologies. Included in these are contrast esophagram, computed tomography, high-resolution manometry, and 24-hour pH monitoring. Two novel measurement technologies, the functional lumen imaging probe (FLIP) and mucosal impedance (MI) catheter have recently introduced and studied. This review will discuss the technological basis of these tools and the evidence behind their application in the measurement of esophageal anatomy, physiology, and histology pertaining to a number of diseases, including gastroesophageal reflux disease, achalasia, and esosinophilic esophagitis...
November 2018: Thoracic Surgery Clinics
https://read.qxmd.com/read/30082108/dual-ph-probes-without-proximal-esophageal-and-pharyngeal-impedance-may-be-deficient-in-diagnosing-lpr
#34
JOURNAL ARTICLE
Lawrence F Borges, Walter W Chan, Thomas L Carroll
BACKGROUND: Laryngopharyngeal reflux (LPR) is commonly treated with empiric acid suppression. More evidence points to pepsin in the pathophysiology of LPR. Previous studies have evaluated esophageal impedance in patients who had previously failed high dose proton pump inhibitor (PPI) using older catheters without proximal esophageal (just under the upper esophageal sphincter) and pharyngeal impedance sensors. The aim of this study was to compare what traditional diagnostic tools, used for esophageal reflux, would detect and diagnose compared with what a combined hypopharyngeal-esophageal MII catheter with dual pH (HEMII-pH) can detect in the esophagus and pharynx in patients with suspected LPR...
August 3, 2018: Journal of Voice
https://read.qxmd.com/read/30041936/effects-of-smoking-exposure-in-infants-on-gastroesophageal-reflux-as-a-function-of-the-sleep-wakefulness-state
#35
JOURNAL ARTICLE
Djamal Djeddi, Erwan Stephan-Blanchard, André Léké, Mohamed Ammari, Stephane Delanaud, Anne-Sophie Lemaire-Hurtel, Véronique Bach, Frédéric Telliez
OBJECTIVE: To determine whether perinatal smoking exposure is associated with gastroesophageal reflux (GER)-related changes in sleep-wakefulness states in neonates. STUDY DESIGN: Thirty-one neonates, referred for the investigation of suspected GER, were recruited and underwent multichannel impedance-pH monitoring and synchronized 8- to 12-hour polysomnography. The infants' exposure to tobacco smoke was estimated by means of a urine cotinine assay. The total number, frequency (h-1 ), and mean duration (minutes) of GER-pH (reflux events detected by the pH electrode only) and GER-imp (reflux events with bolus movement detected by impedance) events were determined...
July 2, 2018: Journal of Pediatrics
https://read.qxmd.com/read/29754440/indications-and-interpretation-of-esophageal-function-testing
#36
REVIEW
C Prakash Gyawali, Nicola de Bortoli, John Clarke, Carla Marinelli, Salvatore Tolone, Sabine Roman, Edoardo Savarino
Esophageal symptoms are common, and can arise from mucosal, motor, functional, and neoplastic processes, among others. Judicious use of diagnostic testing can help define the etiology of symptoms and can direct management. Endoscopy, esophageal high-resolution manometry (HRM), ambulatory pH or pH-impedance manometry, and barium radiography are commonly used for esophageal function testing; functional lumen imaging probe is an emerging option. Recent consensus guidelines have provided direction in using test findings toward defining mechanisms of esophageal symptoms...
December 2018: Annals of the New York Academy of Sciences
https://read.qxmd.com/read/29230485/-importance-of-functional-diagnostics-in-gastroenterology
#37
REVIEW
M Hollenbach, A Hoffmeister, J Rosendahl, J Mössner
In this review article important and frequently used investigation methods for gastrointestinal functional diagnostics are presented. Some other rarely used special investigations are also explained. The hydrogen breath test is simple to carry out, ubiquitously available and enables the detection of lactose, fructose and sorbitol malabsorption. Furthermore, by the application of glucose, the test can be carried out when there is a suspicion of abnormal intestinal bacterial colonization and using lactulose for measuring small intestinal transit time...
January 2018: Der Internist
https://read.qxmd.com/read/28881892/influence-of-esophagectomy-on-the-gastroesophageal-reflux-in-patients-with-esophageal-cancer
#38
JOURNAL ARTICLE
D Kim, Y W Min, J G Park, H Lee, B-H Min, J H Lee, P-L Rhee, J J Kim, J I Zo
This study aims to assess the influence of esophagectomy with gastric transposition on the gastroesophageal reflux (GER) and gastric acidity in patients with esophageal cancer. Data on 53 esophageal cancer patients who underwent 24-hour impedance-pH monitoring after esophagectomy were retrospectively analyzed. We used a solid-state esophageal pH probe in which the esophageal pH sensor is placed 1.5 cm distal to the upper esophageal sphincter and the gastric pH sensor is located 15 cm distal to the esophageal pH channel...
December 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://read.qxmd.com/read/28544357/classification-of-esophageal-motor-findings-in-gastro-esophageal-reflux-disease-conclusions-from-an-international-consensus-group
#39
REVIEW
C P Gyawali, S Roman, A J Bredenoord, M Fox, J Keller, J E Pandolfino, D Sifrim, R Tatum, R Yadlapati, E Savarino
BACKGROUND: High-resolution manometry (HRM) has resulted in new revelations regarding the pathophysiology of gastro-esophageal reflux disease (GERD). The impact of new HRM motor paradigms on reflux burden needs further definition, leading to a modern approach to motor testing in GERD. METHODS: Focused literature searches were conducted, evaluating pathophysiology of GERD with emphasis on HRM. The results were discussed with an international group of experts to develop a consensus on the role of HRM in GERD...
December 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://read.qxmd.com/read/27557545/esophageal-acid-clearance-during-random-swallowing-is-faster-in-patients-with-barrett-s-esophagus-than-in-healthy-controls
#40
JOURNAL ARTICLE
Christian Lottrup, Anne L Krarup, Hans Gregersen, Per Ejstrud, Asbjørn M Drewes
Background/Aims: Impaired esophageal acid clearance may be a contributing factor in the pathogenesis of Barrett's esophagus. However, few studies have measured acid clearance as such in these patients. In this explorative, cross-sectional study, we aimed to compare esophageal acid clearance and swallowing rate in patients with Barrett's esophagus to that in healthy controls. Methods: A total of 26 patients with histology-confirmed Barrett's esophagus and 12 healthy controls underwent (1) upper endoscopy, (2) an acid clearance test using a pH-impedance probe under controlled conditions including controlled and random swallowing, and (3) an ambulatory pH-impedance measurement...
October 30, 2016: Journal of Neurogastroenterology and Motility
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